GOLGA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.78171154
2negative regulation of potassium ion transmembrane transport (GO:1901380)6.11721795
3sarcomere organization (GO:0045214)5.87163945
4cardiac myofibril assembly (GO:0055003)5.29917716
5plasma membrane repair (GO:0001778)5.29494385
6myofibril assembly (GO:0030239)5.05808832
7actin-myosin filament sliding (GO:0033275)4.74325929
8muscle filament sliding (GO:0030049)4.74325929
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.70177325
10regulation of skeletal muscle contraction (GO:0014819)4.66167024
11sarcoplasmic reticulum calcium ion transport (GO:0070296)4.59290386
12mitotic sister chromatid cohesion (GO:0007064)4.46445430
13carnitine shuttle (GO:0006853)4.44094356
14bundle of His cell to Purkinje myocyte communication (GO:0086069)4.28589021
15regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.25711581
16cardiac muscle contraction (GO:0060048)4.17636542
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.17610119
18actin-mediated cell contraction (GO:0070252)4.07856985
19cardiac muscle cell development (GO:0055013)4.06113869
20ventricular cardiac muscle cell action potential (GO:0086005)3.99356185
21actomyosin structure organization (GO:0031032)3.95495130
22fatty acid transmembrane transport (GO:1902001)3.87017250
23pyrimidine ribonucleoside catabolic process (GO:0046133)3.81655162
24cardiac cell development (GO:0055006)3.80343956
25striated muscle contraction (GO:0006941)3.71587395
26carnitine transmembrane transport (GO:1902603)3.70156452
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.68865862
28tricarboxylic acid cycle (GO:0006099)3.64776756
29amino-acid betaine transport (GO:0015838)3.54877016
30carnitine transport (GO:0015879)3.54877016
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54336501
32positive regulation of histone deacetylation (GO:0031065)3.54333537
33hormone catabolic process (GO:0042447)3.50308426
34cell communication involved in cardiac conduction (GO:0086065)3.49267495
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.48860570
36cytidine deamination (GO:0009972)3.47857697
37cytidine metabolic process (GO:0046087)3.47857697
38cytidine catabolic process (GO:0006216)3.47857697
39nuclear pore complex assembly (GO:0051292)3.43926677
40cardiac muscle hypertrophy (GO:0003300)3.42933891
41actin filament-based movement (GO:0030048)3.40108872
42COPII vesicle coating (GO:0048208)3.39550999
43creatine metabolic process (GO:0006600)3.39325060
44monoubiquitinated protein deubiquitination (GO:0035520)3.38611429
45regulation of establishment of cell polarity (GO:2000114)3.34981228
46regulation of actin filament-based movement (GO:1903115)3.33907872
47regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.31871353
48striated muscle hypertrophy (GO:0014897)3.28179314
49adult heart development (GO:0007512)3.26635324
50skeletal muscle adaptation (GO:0043501)3.25393012
51interkinetic nuclear migration (GO:0022027)3.24545798
52relaxation of cardiac muscle (GO:0055119)3.22299789
53cardiac muscle tissue morphogenesis (GO:0055008)3.21799106
54regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.21118761
55negative regulation of cell size (GO:0045792)3.10667453
56negative regulation of potassium ion transport (GO:0043267)3.09139627
57regulation of establishment or maintenance of cell polarity (GO:0032878)3.05759818
58embryonic retina morphogenesis in camera-type eye (GO:0060059)3.02207450
59positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.01859881
60regulation of p38MAPK cascade (GO:1900744)3.00700436
61intestinal epithelial cell development (GO:0060576)2.97344088
62NLS-bearing protein import into nucleus (GO:0006607)2.95856307
63muscle tissue morphogenesis (GO:0060415)2.94269480
64regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.94078030
65ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.92831323
662-oxoglutarate metabolic process (GO:0006103)2.92537821
67heart trabecula formation (GO:0060347)2.91427579
68regulation of striated muscle contraction (GO:0006942)2.90733348
69negative regulation of keratinocyte proliferation (GO:0010839)2.89680058
70early endosome to late endosome transport (GO:0045022)2.89235608
71regulation of membrane repolarization (GO:0060306)2.87450780
72skeletal muscle contraction (GO:0003009)2.86882045
73lysine catabolic process (GO:0006554)2.85788652
74lysine metabolic process (GO:0006553)2.85788652
75daunorubicin metabolic process (GO:0044597)2.85399887
76polyketide metabolic process (GO:0030638)2.85399887
77doxorubicin metabolic process (GO:0044598)2.85399887
78* establishment of protein localization to Golgi (GO:0072600)2.85237922
79regulation of relaxation of muscle (GO:1901077)2.84903901
80nuclear pore organization (GO:0006999)2.84637195
81regulation of cell communication by electrical coupling (GO:0010649)2.83699432
82cell communication by electrical coupling (GO:0010644)2.83211841
83regulation of RNA export from nucleus (GO:0046831)2.82609506
84striated muscle atrophy (GO:0014891)2.81151515
85quaternary ammonium group transport (GO:0015697)2.80641016
86otic vesicle formation (GO:0030916)2.78990451
87muscle contraction (GO:0006936)2.77170792
88macroautophagy (GO:0016236)2.76341135
89muscle hypertrophy (GO:0014896)2.75679712
90regulation of DNA endoreduplication (GO:0032875)2.74557372
91desmosome organization (GO:0002934)2.73499961
92detection of calcium ion (GO:0005513)2.70309609
93growth hormone secretion (GO:0030252)2.69718481
94positive regulation of cation channel activity (GO:2001259)2.67669144
95regulation of protein polyubiquitination (GO:1902914)2.67323143
96intracellular lipid transport (GO:0032365)2.66328167
97regulation of sequestering of triglyceride (GO:0010889)2.65791609
98aspartate family amino acid catabolic process (GO:0009068)2.65483338
99striated muscle adaptation (GO:0014888)2.65272301
1004-hydroxyproline metabolic process (GO:0019471)2.64599889
101cardiac muscle cell action potential (GO:0086001)2.63613294
102sister chromatid cohesion (GO:0007062)2.63543932
103cardiac conduction (GO:0061337)2.63377030
104biotin metabolic process (GO:0006768)2.62838790
105regulation of the force of heart contraction (GO:0002026)2.61890854
106positive regulation of protein autophosphorylation (GO:0031954)2.61591904
107response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.61259973
108regulation of centriole replication (GO:0046599)2.60857406
109genitalia morphogenesis (GO:0035112)2.60847508
110cardiac muscle cell action potential involved in contraction (GO:0086002)2.59352453
111regulation of fatty acid oxidation (GO:0046320)2.59271143
112UDP-N-acetylglucosamine metabolic process (GO:0006047)2.59119311
113negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.58411521
114embryonic foregut morphogenesis (GO:0048617)2.58256893
115protein targeting to vacuole (GO:0006623)2.57404084
116protein targeting to lysosome (GO:0006622)2.57404084
117establishment of protein localization to vacuole (GO:0072666)2.57404084
118membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.57219985
119positive regulation of glycogen biosynthetic process (GO:0045725)2.56174794
120hemidesmosome assembly (GO:0031581)2.55972904
121regulation of sarcomere organization (GO:0060297)2.55890352
122* protein targeting to Golgi (GO:0000042)2.55771536
123glucan catabolic process (GO:0009251)2.55625025
124regulation of glucose import in response to insulin stimulus (GO:2001273)2.55283361
125* retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55020513
126glycogen catabolic process (GO:0005980)2.54634490
127muscle system process (GO:0003012)2.54516076
128positive regulation of glycolytic process (GO:0045821)2.54151447
129pericardium development (GO:0060039)2.53692526
130regulation of heart rate by cardiac conduction (GO:0086091)2.52957217
131regulation of calcium ion transmembrane transporter activity (GO:1901019)2.51628267
132protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.49177776
133cytoplasmic mRNA processing body assembly (GO:0033962)2.42455388
134Sertoli cell development (GO:0060009)2.42429593
135pore complex assembly (GO:0046931)2.42265962
136endocardial cushion development (GO:0003197)2.37901643
137regulation of transforming growth factor beta2 production (GO:0032909)2.34620532
138regulation of hexokinase activity (GO:1903299)2.33538904
139regulation of glucokinase activity (GO:0033131)2.33538904
140auditory receptor cell differentiation (GO:0042491)2.33292460
141ovulation from ovarian follicle (GO:0001542)2.32597795
142anterior/posterior axis specification, embryo (GO:0008595)2.30827157
143negative regulation of protein localization to cell surface (GO:2000009)2.30617815
144regulation of meiosis I (GO:0060631)2.28434157
145iron ion import (GO:0097286)2.27500515
146retina vasculature morphogenesis in camera-type eye (GO:0061299)2.27196757
147regulation of nucleobase-containing compound transport (GO:0032239)2.25656698
148Golgi to endosome transport (GO:0006895)2.23065924
149regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.21708708
150cell adhesion mediated by integrin (GO:0033627)2.21611088
151regulation of keratinocyte proliferation (GO:0010837)2.21133767
152insulin-like growth factor receptor signaling pathway (GO:0048009)2.20423959
153endocrine hormone secretion (GO:0060986)2.19536898
154negative regulation of hormone biosynthetic process (GO:0032353)2.17330512
155Golgi organization (GO:0007030)2.17248183
156keratinocyte development (GO:0003334)2.15528324
157nucleus localization (GO:0051647)2.14235100
158positive regulation of macroautophagy (GO:0016239)2.12401233
159regulation of protein glycosylation (GO:0060049)2.12329681
160tight junction assembly (GO:0070830)2.11950327
161sequestering of extracellular ligand from receptor (GO:0035581)2.11051831
162vesicle transport along microtubule (GO:0047496)2.10951462
163hippo signaling (GO:0035329)2.10162854
164dorsal/ventral axis specification (GO:0009950)2.09971305
165very-low-density lipoprotein particle assembly (GO:0034379)2.09878602
166snRNA transcription (GO:0009301)2.08612492
167regulation of centrosome duplication (GO:0010824)2.07511224
168fatty acid homeostasis (GO:0055089)2.07287293
169microtubule anchoring (GO:0034453)2.05603270
170interleukin-6-mediated signaling pathway (GO:0070102)2.05419352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.31579583
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.01995127
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.00647548
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51235373
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49194326
6* TBX20_22328084_ChIP-Seq_HEART_Mouse2.42704137
7* TBX20_22080862_ChIP-Seq_HEART_Mouse2.42704137
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.39550509
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.35032801
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28925926
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25446292
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.25307715
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24239432
14* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.23788712
15GBX2_23144817_ChIP-Seq_PC3_Human2.12949516
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.08939257
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.07350400
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.06480846
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.04400323
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.99818936
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.99818936
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.99818936
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98195000
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97806819
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96685357
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.95630318
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.90294517
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87142897
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85061776
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82917739
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.73907880
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73643247
33TP53_16413492_ChIP-PET_HCT116_Human1.71744677
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71109844
35TAF15_26573619_Chip-Seq_HEK293_Human1.71037796
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70444948
37GATA1_22025678_ChIP-Seq_K562_Human1.70128888
38* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69495816
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65535575
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65291429
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65043997
42SMAD4_21799915_ChIP-Seq_A2780_Human1.62302738
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.61591802
44CJUN_26792858_Chip-Seq_BT549_Human1.61123408
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.61015625
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60868659
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.60277584
48FUS_26573619_Chip-Seq_HEK293_Human1.60166027
49ZNF263_19887448_ChIP-Seq_K562_Human1.59844553
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58907284
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.57441620
52* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55858875
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55836173
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55836173
55* STAT3_23295773_ChIP-Seq_U87_Human1.52862487
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.52200838
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50533127
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50528805
59BRD4_25478319_ChIP-Seq_HGPS_Human1.50515228
60VDR_22108803_ChIP-Seq_LS180_Human1.50427035
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49150465
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.49010532
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48207429
64* P300_19829295_ChIP-Seq_ESCs_Human1.47680913
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47428342
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46209800
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.46130631
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.45542202
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.43545836
70* TCF4_23295773_ChIP-Seq_U87_Human1.42133081
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41846937
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41394769
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.41150378
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41148242
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40156739
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39224669
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38105872
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37991676
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.36747501
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35809887
81ER_23166858_ChIP-Seq_MCF-7_Human1.35195873
82* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33898282
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33735708
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32781340
85KDM2B_26808549_Chip-Seq_K562_Human1.32600433
86AHR_22903824_ChIP-Seq_MCF-7_Human1.32383746
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32141212
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.31727951
89EWS_26573619_Chip-Seq_HEK293_Human1.31542111
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31537832
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31145377
92CDX2_22108803_ChIP-Seq_LS180_Human1.30993964
93AR_21909140_ChIP-Seq_LNCAP_Human1.30940951
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30476708
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30403076
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.30019940
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29825695
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29499609
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29207010
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28514363
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27037289
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26703182
103GATA6_25053715_ChIP-Seq_YYC3_Human1.26691766
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25349055
105TCF7_22412390_ChIP-Seq_EML_Mouse1.24547747
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24439206
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23736113
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23048797
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22049693
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21972486
111BCAT_22108803_ChIP-Seq_LS180_Human1.21860759
112FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21819245
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.21434404
114ISL1_27105846_Chip-Seq_CPCs_Mouse1.20404693
115AR_25329375_ChIP-Seq_VCAP_Human1.19979534
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19418330
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18317301
118CREB1_26743006_Chip-Seq_LNCaP_Human1.18312590
119KDM2B_26808549_Chip-Seq_DND41_Human1.18223509
120WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16119101
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15753597
122RACK7_27058665_Chip-Seq_MCF-7_Human1.15374433
123* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14808533
124* TP63_23658742_ChIP-Seq_EP156T_Human1.14369825
125TP53_18474530_ChIP-ChIP_U2OS_Human1.14234966
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13354944
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13214016
128TP63_17297297_ChIP-ChIP_HaCaT_Human1.13109362
129NFE2_27457419_Chip-Seq_LIVER_Mouse1.12300577
130P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12144505
131CBP_20019798_ChIP-Seq_JUKART_Human1.11975926
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11975926
133* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11827947
134SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11771502
135CLOCK_20551151_ChIP-Seq_293T_Human1.11228520
136SMAD3_21741376_ChIP-Seq_HESCs_Human1.11218721
137RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10820652
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10251374
139TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10202683
140P53_22387025_ChIP-Seq_ESCs_Mouse1.09966527
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09728603
142SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09728603
143GATA2_21666600_ChIP-Seq_HMVEC_Human1.09289925
144TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09101401
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08537762
146CMYC_18555785_Chip-Seq_ESCs_Mouse1.08440681
147TRIM28_21343339_ChIP-Seq_HEK293_Human1.07445889
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07237664
149TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06802156
150YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06549890
151* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06226783
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05771522
153NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05721379
154AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05380852
155ARNT_22903824_ChIP-Seq_MCF-7_Human1.02926023
156ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01875631
157FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01240077
158* TP63_22573176_ChIP-Seq_HFKS_Human1.01004027
159ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99800272
160ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97122257
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96476468
162EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95589951
163ATF3_27146783_Chip-Seq_COLON_Human0.95531052
164TCF4_18268006_ChIP-ChIP_LS174T_Human0.95434241
165NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95138432
166* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94893240
167DROSHA_22980978_ChIP-Seq_HELA_Human0.94445011
168RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93829300
169* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93647503
170NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93449813
171KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93404831
172GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92945540
173GATA3_24758297_ChIP-Seq_MCF-7_Human0.91586276
174GATA4_25053715_ChIP-Seq_YYC3_Human0.90380543
175FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88074194
176SMAD4_21741376_ChIP-Seq_HESCs_Human0.85889659
177LXR_22292898_ChIP-Seq_THP-1_Human0.84496906
178* GATA1_19941826_ChIP-Seq_K562_Human0.84476562
179NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83070892
180CTCF_27219007_Chip-Seq_Bcells_Human0.82520407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.38549930
2MP0004084_abnormal_cardiac_muscle4.17140252
3MP0003646_muscle_fatigue3.89624337
4MP0000751_myopathy3.81679370
5MP0000749_muscle_degeneration3.58039221
6MP0004036_abnormal_muscle_relaxation3.38900771
7MP0004215_abnormal_myocardial_fiber3.36417776
8MP0005330_cardiomyopathy2.83921550
9MP0004087_abnormal_muscle_fiber2.81818336
10MP0000569_abnormal_digit_pigmentation2.73385253
11MP0004145_abnormal_muscle_electrophysio2.65250643
12MP0008057_abnormal_DNA_replication2.54134251
13MP0002269_muscular_atrophy2.48218149
14MP0000750_abnormal_muscle_regeneration2.36551953
15MP0004264_abnormal_extraembryonic_tissu2.34077358
16MP0003705_abnormal_hypodermis_morpholog2.29273454
17MP0010630_abnormal_cardiac_muscle2.26033322
18MP0004130_abnormal_muscle_cell2.24373257
19MP0003941_abnormal_skin_development2.21312854
20MP0002106_abnormal_muscle_physiology2.20642239
21MP0005620_abnormal_muscle_contractility2.20440841
22MP0008961_abnormal_basal_metabolism2.17422564
23MP0002972_abnormal_cardiac_muscle2.16361412
24MP0004043_abnormal_pH_regulation2.15103395
25MP0003137_abnormal_impulse_conducting2.12392315
26MP0008775_abnormal_heart_ventricle2.06330762
27MP0000759_abnormal_skeletal_muscle1.93678562
28MP0001299_abnormal_eye_distance/1.91551372
29MP0003868_abnormal_feces_composition1.90617501
30MP0000747_muscle_weakness1.88948078
31MP0005369_muscle_phenotype1.86200559
32MP0010678_abnormal_skin_adnexa1.83498648
33MP0002877_abnormal_melanocyte_morpholog1.80976910
34MP0000383_abnormal_hair_follicle1.80906246
35MP0000427_abnormal_hair_cycle1.80339767
36MP0002909_abnormal_adrenal_gland1.79182916
37MP0005275_abnormal_skin_tensile1.75908385
38MP0005385_cardiovascular_system_phenoty1.75433574
39MP0001544_abnormal_cardiovascular_syste1.75433574
40MP0002332_abnormal_exercise_endurance1.73082712
41MP0005670_abnormal_white_adipose1.72007393
42MP0008438_abnormal_cutaneous_collagen1.70817237
43MP0006138_congestive_heart_failure1.70688369
44MP0005666_abnormal_adipose_tissue1.70473855
45MP0004085_abnormal_heartbeat1.66232374
46MP0004185_abnormal_adipocyte_glucose1.65039526
47MP0004484_altered_response_of1.62394048
48MP0002254_reproductive_system_inflammat1.54600564
49MP0002127_abnormal_cardiovascular_syste1.53223053
50MP0003283_abnormal_digestive_organ1.52866053
51MP0005408_hypopigmentation1.51070145
52MP0008877_abnormal_DNA_methylation1.49677515
53MP0003045_fibrosis1.48684478
54MP0004233_abnormal_muscle_weight1.46537702
55MP0003828_pulmonary_edema1.46475135
56MP0009780_abnormal_chondrocyte_physiolo1.44735742
57MP0005409_darkened_coat_color1.39431634
58MP0003252_abnormal_bile_duct1.36422697
59MP0010234_abnormal_vibrissa_follicle1.35218032
60MP0003221_abnormal_cardiomyocyte_apopto1.31810598
61MP0005375_adipose_tissue_phenotype1.31433495
62MP0006054_spinal_hemorrhage1.26953085
63MP0004510_myositis1.25379205
64MP0002108_abnormal_muscle_morphology1.20886104
65MP0003950_abnormal_plasma_membrane1.16907943
66MP0003787_abnormal_imprinting1.13464436
67MP0002234_abnormal_pharynx_morphology1.11294343
68MP0002060_abnormal_skin_morphology1.10964632
69MP0000266_abnormal_heart_morphology1.10716352
70MP0003300_gastrointestinal_ulcer1.08965577
71MP0000003_abnormal_adipose_tissue1.08586485
72MP0005257_abnormal_intraocular_pressure1.07104766
73MP0009697_abnormal_copulation1.06126777
74MP0003385_abnormal_body_wall1.05534411
75MP0002078_abnormal_glucose_homeostasis1.04896684
76MP0006035_abnormal_mitochondrial_morpho1.04687150
77MP0006036_abnormal_mitochondrial_physio1.03942069
78MP0000733_abnormal_muscle_development1.03335062
79MP0003183_abnormal_peptide_metabolism1.03054951
80MP0000678_abnormal_parathyroid_gland1.02736824
81MP0002876_abnormal_thyroid_physiology1.02622538
82MP0003566_abnormal_cell_adhesion1.02362300
83MP0003937_abnormal_limbs/digits/tail_de1.01872191
84MP0000647_abnormal_sebaceous_gland1.00589817
85MP0010352_gastrointestinal_tract_polyps1.00432975
86MP0000579_abnormal_nail_morphology0.98645691
87MP0005266_abnormal_metabolism0.94278998
88MP0002693_abnormal_pancreas_physiology0.90818703
89MP0005365_abnormal_bile_salt0.90594658
90MP0001849_ear_inflammation0.90262616
91MP0009384_cardiac_valve_regurgitation0.89643181
92MP0001661_extended_life_span0.89059585
93MP0009703_decreased_birth_body0.87683755
94MP0002168_other_aberrant_phenotype0.86908103
95MP0004858_abnormal_nervous_system0.86481120
96MP0010329_abnormal_lipoprotein_level0.86284561
97MP0010307_abnormal_tumor_latency0.85480217
98MP0000432_abnormal_head_morphology0.83657544
99MP0010368_abnormal_lymphatic_system0.83035039
100MP0005503_abnormal_tendon_morphology0.83007851
101MP0005085_abnormal_gallbladder_physiolo0.82830143
102MP0002084_abnormal_developmental_patter0.81505272
103MP0000013_abnormal_adipose_tissue0.81425888
104MP0002088_abnormal_embryonic_growth/wei0.80459482
105MP0003984_embryonic_growth_retardation0.79586236
106MP0001765_abnormal_ion_homeostasis0.78822508
107MP0002971_abnormal_brown_adipose0.78810176
108MP0000428_abnormal_craniofacial_morphol0.77713429
109MP0003890_abnormal_embryonic-extraembry0.76008163
110MP0002295_abnormal_pulmonary_circulatio0.75856932
111MP0000377_abnormal_hair_follicle0.75548879
112MP0001666_abnormal_nutrient_absorption0.75033564
113MP0003755_abnormal_palate_morphology0.74192816
114MP0004197_abnormal_fetal_growth/weight/0.73784358
115MP0001879_abnormal_lymphatic_vessel0.73587432
116MP0002139_abnormal_hepatobiliary_system0.73426829
117MP0002925_abnormal_cardiovascular_devel0.72903921
118MP0005451_abnormal_body_composition0.72760635
119MP0005023_abnormal_wound_healing0.72195358
120MP0003195_calcinosis0.71806466
121MP0009115_abnormal_fat_cell0.71332740
122MP0005410_abnormal_fertilization0.70454154
123MP0004272_abnormal_basement_membrane0.70271473
124MP0005623_abnormal_meninges_morphology0.69770854
125MP0001944_abnormal_pancreas_morphology0.69020266
126MP0000627_abnormal_mammary_gland0.68153778
127MP0005187_abnormal_penis_morphology0.67388333
128MP0005319_abnormal_enzyme/_coenzyme0.66107433
129MP0005076_abnormal_cell_differentiation0.65422451
130MP0005360_urolithiasis0.64994460
131MP0002128_abnormal_blood_circulation0.64269975
132MP0002896_abnormal_bone_mineralization0.64263790
133MP0005380_embryogenesis_phenotype0.62130157
134MP0001672_abnormal_embryogenesis/_devel0.62130157
135MP0005248_abnormal_Harderian_gland0.59328129
136MP0005165_increased_susceptibility_to0.59143066
137MP0000230_abnormal_systemic_arterial0.56965299
138MP0002118_abnormal_lipid_homeostasis0.56397061
139MP0002970_abnormal_white_adipose0.54966282
140MP0003011_delayed_dark_adaptation0.54903076
141MP0002796_impaired_skin_barrier0.54043231
142MP0003935_abnormal_craniofacial_develop0.53172679

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.83085142
2Exercise-induced muscle cramps (HP:0003710)5.44959971
3Exercise-induced myalgia (HP:0003738)5.41692918
4Ventricular tachycardia (HP:0004756)5.35920346
5Hyporeflexia of lower limbs (HP:0002600)5.12569740
6Difficulty running (HP:0009046)4.98956201
7Calf muscle hypertrophy (HP:0008981)4.97275318
8Hyperinsulinemic hypoglycemia (HP:0000825)4.77459672
9Muscle hypertrophy of the lower extremities (HP:0008968)4.72770874
10Muscle fiber splitting (HP:0003555)4.70506153
11Right ventricular cardiomyopathy (HP:0011663)4.70481949
12Increased connective tissue (HP:0009025)4.64877343
13Myoglobinuria (HP:0002913)4.55996111
14Atrial fibrillation (HP:0005110)4.02701425
15Abnormality of the calf musculature (HP:0001430)4.01197341
16Volvulus (HP:0002580)3.99545206
17Subaortic stenosis (HP:0001682)3.77768865
18Abnormality of the left ventricular outflow tract (HP:0011103)3.77768865
19Bundle branch block (HP:0011710)3.72925876
20Primary atrial arrhythmia (HP:0001692)3.70967478
21Papillary thyroid carcinoma (HP:0002895)3.66634475
22EMG: myopathic abnormalities (HP:0003458)3.63748529
23Ketoacidosis (HP:0001993)3.49967685
24Supraventricular tachycardia (HP:0004755)3.48212345
25Syncope (HP:0001279)3.46096788
26Supraventricular arrhythmia (HP:0005115)3.44087867
27Hypoglycemic coma (HP:0001325)3.40687905
28Asymmetric septal hypertrophy (HP:0001670)3.38326909
29Lipoatrophy (HP:0100578)3.33785440
30Mildly elevated creatine phosphokinase (HP:0008180)3.30664056
31Difficulty climbing stairs (HP:0003551)3.29532359
32Testicular atrophy (HP:0000029)3.15201049
33Prolonged QT interval (HP:0001657)3.11258326
34EMG: neuropathic changes (HP:0003445)3.09488306
35Ventricular arrhythmia (HP:0004308)3.08677326
36Dilated cardiomyopathy (HP:0001644)3.04448064
37Type 1 muscle fiber predominance (HP:0003803)3.01653021
38Muscle fiber inclusion bodies (HP:0100299)2.99864215
39Hypoplastic ischia (HP:0003175)2.97335166
40Pancreatic islet-cell hyperplasia (HP:0004510)2.91979085
41Hyperglycemia (HP:0003074)2.91767797
42Increased variability in muscle fiber diameter (HP:0003557)2.88762702
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.86262384
44Insulin-resistant diabetes mellitus (HP:0000831)2.80880240
45Rhabdomyolysis (HP:0003201)2.77732414
46Ventricular fibrillation (HP:0001663)2.75818315
47Myotonia (HP:0002486)2.74838731
48Fair hair (HP:0002286)2.73419503
49Heart block (HP:0012722)2.72275441
50Abnormality of the ischium (HP:0003174)2.64210501
51Abnormal atrioventricular conduction (HP:0005150)2.64158643
52Palpitations (HP:0001962)2.61944070
53Hypoplastic labia majora (HP:0000059)2.59935149
54Abnormality of skeletal muscle fiber size (HP:0012084)2.58967906
55Abnormality of the lower motor neuron (HP:0002366)2.55545981
56Atrioventricular block (HP:0001678)2.52467283
57Proximal tubulopathy (HP:0000114)2.47297300
58Hepatoblastoma (HP:0002884)2.44360410
59Ketosis (HP:0001946)2.42873952
60Generalized hypopigmentation of hair (HP:0011358)2.42872654
61Abnormality of the labia majora (HP:0012881)2.42355495
62Hyperkalemia (HP:0002153)2.34707602
63Skin nodule (HP:0200036)2.34328294
64Muscle stiffness (HP:0003552)2.28555138
65Curly hair (HP:0002212)2.27605726
66Limited hip movement (HP:0008800)2.26934506
67Abnormality of endocrine pancreas physiology (HP:0012093)2.24655702
68Abnormality of the pancreatic islet cells (HP:0006476)2.24655702
69Overgrowth (HP:0001548)2.22679052
70Hypobetalipoproteinemia (HP:0003563)2.22109747
71Abnormal EKG (HP:0003115)2.21001272
72Multiple enchondromatosis (HP:0005701)2.20822235
73Renal cortical cysts (HP:0000803)2.20665544
74Proximal amyotrophy (HP:0007126)2.20466815
75Truncal obesity (HP:0001956)2.18400682
76Large for gestational age (HP:0001520)2.18387690
77Resting tremor (HP:0002322)2.18007759
78Hypolipoproteinemia (HP:0010981)2.17154846
79Hypoglycemic seizures (HP:0002173)2.17042704
80Abnormal pancreas size (HP:0012094)2.16535820
81Hamartoma of the eye (HP:0010568)2.16270076
82Distal lower limb muscle weakness (HP:0009053)2.15456257
83Thyroid carcinoma (HP:0002890)2.15446816
84Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15090578
85Abnormality of the salivary glands (HP:0010286)2.12119095
86Nemaline bodies (HP:0003798)2.08393588
87Myopathic facies (HP:0002058)2.07670932
88Progressive muscle weakness (HP:0003323)2.07383354
89Arterial tortuosity (HP:0005116)2.07124475
90Biliary tract neoplasm (HP:0100574)2.03937808
91Lymphangioma (HP:0100764)2.02491003
92Neck muscle weakness (HP:0000467)2.01399789
93Long clavicles (HP:0000890)1.98968174
94Frequent falls (HP:0002359)1.98577347
95Abnormal biliary tract morphology (HP:0012440)1.98379728
96Vascular tortuosity (HP:0004948)1.97859683
97Cystic hygroma (HP:0000476)1.97389769
98Abnormality of the nasal septum (HP:0000419)1.97200561
99Distal lower limb amyotrophy (HP:0008944)1.97126134
100Facial diplegia (HP:0001349)1.96846515
101Scapular winging (HP:0003691)1.96824667
102Abnormality of the renal cortex (HP:0011035)1.95583038
103Protruding tongue (HP:0010808)1.94898435
104Gout (HP:0001997)1.94536765
105Ragged-red muscle fibers (HP:0003200)1.92721569
106Hip contracture (HP:0003273)1.90306144
107Hypochromic microcytic anemia (HP:0004840)1.90031358
108Abnormality of the pubic bones (HP:0003172)1.89625889
109Aneurysm (HP:0002617)1.89217026
110Round ear (HP:0100830)1.88186484
111Areflexia of lower limbs (HP:0002522)1.84340169
112Laryngomalacia (HP:0001601)1.83505721
113Left ventricular hypertrophy (HP:0001712)1.83437917
114Symptomatic seizures (HP:0011145)1.82951935
115Atrophic scars (HP:0001075)1.82687673
116Hypoalphalipoproteinemia (HP:0003233)1.82371868
117Cardiovascular calcification (HP:0011915)1.81458378
118Chromsome breakage (HP:0040012)1.80884741
119Dysmetric saccades (HP:0000641)1.80651310
120Hyperventilation (HP:0002883)1.80175062
121Bell-shaped thorax (HP:0001591)1.79846311
122Limb-girdle muscle atrophy (HP:0003797)1.78988241
123Lip pit (HP:0100267)1.78791991
124Distal arthrogryposis (HP:0005684)1.77105605
125Distal upper limb amyotrophy (HP:0007149)1.76275063
126Upper limb amyotrophy (HP:0009129)1.76275063
127Generalized muscle weakness (HP:0003324)1.75573454
128Heterotopia (HP:0002282)1.74823148
129Vascular calcification (HP:0004934)1.74602004
130Bilateral microphthalmos (HP:0007633)1.73919440
131Muscular dystrophy (HP:0003560)1.72579616
132Narrow palate (HP:0000189)1.71912248
133Vertebral arch anomaly (HP:0008438)1.70330416
134Ependymoma (HP:0002888)1.69882738
135Rimmed vacuoles (HP:0003805)1.69275406
136Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69120338
137Macroorchidism (HP:0000053)1.68854083
138Late onset (HP:0003584)1.68707831
139Acute myeloid leukemia (HP:0004808)1.62707758
140Low anterior hairline (HP:0000294)1.61434654
141Intrahepatic cholestasis (HP:0001406)1.58540821
142Acanthocytosis (HP:0001927)1.58017420
143Neonatal short-limb short stature (HP:0008921)1.57727769
144Advanced eruption of teeth (HP:0006288)1.56375345
145Cubitus valgus (HP:0002967)1.54927116
146Hypopigmentation of the fundus (HP:0007894)1.53906487
147Aortic aneurysm (HP:0004942)1.53797129
148Prolonged partial thromboplastin time (HP:0003645)1.53164406
149Wide nose (HP:0000445)1.52617309
150Aortic dissection (HP:0002647)1.50292034
151Conjugated hyperbilirubinemia (HP:0002908)1.49749376
152Exotropia (HP:0000577)1.46779710
153Astrocytoma (HP:0009592)1.46633396
154Abnormality of the astrocytes (HP:0100707)1.46633396
155Knee flexion contracture (HP:0006380)1.46466683
156Tibial bowing (HP:0002982)1.46436375
157Aplasia/Hypoplasia of the tibia (HP:0005772)1.46198810
158Blue irides (HP:0000635)1.46140214
159Hydroxyprolinuria (HP:0003080)1.46082065
160Abnormality of proline metabolism (HP:0010907)1.46082065
161Pulmonic stenosis (HP:0001642)1.44425321
162Labial hypoplasia (HP:0000066)1.43795940
163Short chin (HP:0000331)1.41035786
164Absent frontal sinuses (HP:0002688)1.39993284
165Osteomalacia (HP:0002749)1.39733339
166Disproportionate short-trunk short stature (HP:0003521)1.38846115
167Hypoplastic scapulae (HP:0000882)1.38700611
168Aplasia/Hypoplasia of the scapulae (HP:0006713)1.38700611
169Follicular hyperkeratosis (HP:0007502)1.38092603
170Infantile muscular hypotonia (HP:0008947)1.37349175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.02097152
2TTN3.88410428
3OBSCN3.50787968
4PDK33.05052434
5PDK43.05052434
6ERN12.60555565
7ACVR1B2.58394959
8LMTK22.58126914
9PNCK2.52574092
10INSRR2.52166837
11PHKG22.51408573
12PHKG12.51408573
13TRIB32.34436816
14DMPK2.24776110
15TRPM71.99252090
16PDK21.96256571
17MST41.96002629
18WNK11.92658911
19PKN21.86196506
20TNIK1.82772711
21LATS11.73796022
22TAOK31.54103909
23RIPK11.53171517
24BRSK21.51560033
25BMPR1B1.47660604
26PRKD31.45732323
27PDGFRA1.45617351
28STK241.42336991
29MAP3K101.41796123
30PIK3CA1.40767917
31CASK1.40005495
32WNK41.37535374
33EIF2AK31.37082321
34GRK51.36192287
35ERBB31.35149319
36MAP3K71.34909215
37CAMK1G1.33457812
38GRK71.27696582
39CAMK1D1.23023200
40SIK11.22884563
41BCKDK1.22534971
42TGFBR21.22288923
43MKNK21.10060232
44ICK1.09314978
45FRK1.08726582
46PRKAA11.07998434
47SGK21.05237578
48PAK31.04807159
49NEK91.04220788
50TYRO31.03922534
51PRKAA21.03801808
52MTOR1.02277201
53HIPK21.02220270
54FGFR21.01567721
55NLK1.00255270
56BRD41.00114332
57PTK60.99928924
58CAMK40.96281852
59FGFR10.94071854
60PRKD10.93607933
61FGFR30.93217178
62MAP3K20.93098955
63CDC42BPA0.89336300
64STK380.89303932
65EPHB10.84478661
66MYLK0.83430756
67MARK20.82998176
68WNK30.81511069
69LATS20.81333221
70NEK10.79157891
71WEE10.78790145
72PINK10.77419809
73MAPK70.75215283
74ERBB40.74200253
75PTK20.74166725
76OXSR10.73174866
77MST1R0.72335358
78AKT30.72299155
79PLK20.72036385
80TTK0.70535925
81PRKG20.69951887
82PRKCE0.68039082
83CSNK1E0.66318476
84MAP3K10.65794547
85GRK10.62780872
86SGK10.62305539
87NTRK30.61531568
88PDGFRB0.61073855
89PBK0.60755449
90MELK0.60278197
91MAP3K40.60192658
92MET0.59778746
93TAOK10.59035988
94MAP3K30.58843533
95ATM0.57357429
96KSR10.57299102
97CAMK2D0.57140361
98GRK60.57076644
99BCR0.57071775
100PIK3CG0.56570982
101MAP2K40.55451848
102RET0.55293297
103ERBB20.54876903
104CHUK0.54534230
105NEK60.54510898
106MAP3K120.53901778
107MAPK120.53554906
108SGK2230.52410997
109SGK4940.52410997
110TSSK60.51992428
111FGFR40.51906994
112FER0.51645782
113PRKCH0.51326134
114MAP2K30.50898737
115DYRK1B0.49751570
116DDR20.49224373
117NTRK10.48989315
118PAK20.48405004
119FLT30.47934937
120STK390.47852134
121CSF1R0.47279819
122AKT20.47197440
123TIE10.47167676
124MAPK100.47103336
125MUSK0.46422328
126SCYL20.44856607
127ROCK10.44352743
128STK30.43919664
129SGK30.43827307
130PDK10.43129651
131EPHA20.42602491
132STK100.41700289
133PLK40.40963355
134NUAK10.40504504
135STK38L0.39907843
136MAP2K10.39732185
137JAK10.39650170
138PRKD20.38962337
139PRKACG0.38873790
140EIF2AK10.38527515
141MAPKAPK30.38145605
142KSR20.37995759
143EEF2K0.37813424
144RPS6KB10.37357585
145RPS6KB20.36700146
146PRKG10.36570407
147JAK20.35559180
148RPS6KA30.35044415
149PDPK10.33638130
150EPHA30.31159195
151NME10.30933633
152GSK3A0.29191092
153MAP2K60.28702137
154MAP3K50.27705944

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.58772008
2Dilated cardiomyopathy_Homo sapiens_hsa054142.73447303
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.71111739
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.49046138
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37426897
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.31660069
7Propanoate metabolism_Homo sapiens_hsa006402.30703807
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29385733
9Fatty acid degradation_Homo sapiens_hsa000712.15392399
10Cardiac muscle contraction_Homo sapiens_hsa042602.03686342
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98233001
12Type II diabetes mellitus_Homo sapiens_hsa049301.72816946
13Insulin resistance_Homo sapiens_hsa049311.72790468
14Lysine degradation_Homo sapiens_hsa003101.71406761
15Starch and sucrose metabolism_Homo sapiens_hsa005001.57455899
16Glucagon signaling pathway_Homo sapiens_hsa049221.52106339
17Carbon metabolism_Homo sapiens_hsa012001.50778172
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45953245
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44852092
20Fatty acid metabolism_Homo sapiens_hsa012121.42159029
21Fructose and mannose metabolism_Homo sapiens_hsa000511.40831396
22Galactose metabolism_Homo sapiens_hsa000521.39297888
23Tryptophan metabolism_Homo sapiens_hsa003801.38207292
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34677576
25Insulin secretion_Homo sapiens_hsa049111.31396385
26TGF-beta signaling pathway_Homo sapiens_hsa043501.31055570
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29157867
28Fat digestion and absorption_Homo sapiens_hsa049751.28464212
29PPAR signaling pathway_Homo sapiens_hsa033201.27587892
30Pyruvate metabolism_Homo sapiens_hsa006201.24547178
31mTOR signaling pathway_Homo sapiens_hsa041501.23970246
32Complement and coagulation cascades_Homo sapiens_hsa046101.22373110
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.20383609
34Dorso-ventral axis formation_Homo sapiens_hsa043201.18742311
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16833982
36AMPK signaling pathway_Homo sapiens_hsa041521.14770199
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11957618
38Protein export_Homo sapiens_hsa030601.11820507
39Butanoate metabolism_Homo sapiens_hsa006501.11516491
40Insulin signaling pathway_Homo sapiens_hsa049101.06187957
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05588205
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.04276848
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02836676
44Vitamin digestion and absorption_Homo sapiens_hsa049771.02166782
45Bile secretion_Homo sapiens_hsa049761.00423942
46Non-homologous end-joining_Homo sapiens_hsa034501.00276668
47Retinol metabolism_Homo sapiens_hsa008300.99170215
48Adherens junction_Homo sapiens_hsa045200.98484907
49ABC transporters_Homo sapiens_hsa020100.97987562
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95220399
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94831403
52Nitrogen metabolism_Homo sapiens_hsa009100.94645813
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93967318
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93306178
55Arginine biosynthesis_Homo sapiens_hsa002200.92841701
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91566042
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90701777
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.89834633
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89454853
60Hippo signaling pathway_Homo sapiens_hsa043900.89214885
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.88365096
62Sphingolipid metabolism_Homo sapiens_hsa006000.88240906
63Focal adhesion_Homo sapiens_hsa045100.87796011
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.85172367
65MicroRNAs in cancer_Homo sapiens_hsa052060.84845715
66Protein digestion and absorption_Homo sapiens_hsa049740.83705116
67Tight junction_Homo sapiens_hsa045300.83172603
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81645284
69Basal transcription factors_Homo sapiens_hsa030220.81120461
70Renin secretion_Homo sapiens_hsa049240.80228520
71Pancreatic secretion_Homo sapiens_hsa049720.79686210
72FoxO signaling pathway_Homo sapiens_hsa040680.78923011
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78511928
74Prostate cancer_Homo sapiens_hsa052150.77819831
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76234551
76Selenocompound metabolism_Homo sapiens_hsa004500.75861775
77Viral myocarditis_Homo sapiens_hsa054160.75293513
78Sulfur metabolism_Homo sapiens_hsa009200.73929919
79Histidine metabolism_Homo sapiens_hsa003400.71888355
80Glycerolipid metabolism_Homo sapiens_hsa005610.69999063
81Vitamin B6 metabolism_Homo sapiens_hsa007500.69765172
82Oxytocin signaling pathway_Homo sapiens_hsa049210.69157823
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68641836
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68638324
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67377171
86Ether lipid metabolism_Homo sapiens_hsa005650.66159083
87Oocyte meiosis_Homo sapiens_hsa041140.64637539
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63846035
89Inositol phosphate metabolism_Homo sapiens_hsa005620.62536460
90Calcium signaling pathway_Homo sapiens_hsa040200.62018843
91Small cell lung cancer_Homo sapiens_hsa052220.60024684
92cAMP signaling pathway_Homo sapiens_hsa040240.59657319
93Linoleic acid metabolism_Homo sapiens_hsa005910.58878431
94Wnt signaling pathway_Homo sapiens_hsa043100.58292609
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56475742
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56445208
97Arginine and proline metabolism_Homo sapiens_hsa003300.55960216
98Chemical carcinogenesis_Homo sapiens_hsa052040.55637783
99Gastric acid secretion_Homo sapiens_hsa049710.55121901
100Proteoglycans in cancer_Homo sapiens_hsa052050.54782072
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53745884
102Long-term depression_Homo sapiens_hsa047300.53324594
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52998906
104Fatty acid biosynthesis_Homo sapiens_hsa000610.52106926
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52041667
106Melanoma_Homo sapiens_hsa052180.51656992
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51569064
108Caffeine metabolism_Homo sapiens_hsa002320.51072925
109Circadian rhythm_Homo sapiens_hsa047100.50597499
110ECM-receptor interaction_Homo sapiens_hsa045120.50196397
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49808314
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49356274
113Peroxisome_Homo sapiens_hsa041460.48064335
114Biosynthesis of amino acids_Homo sapiens_hsa012300.46651548
115GnRH signaling pathway_Homo sapiens_hsa049120.45299896
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44611166
117Estrogen signaling pathway_Homo sapiens_hsa049150.44550656
118Ovarian steroidogenesis_Homo sapiens_hsa049130.44239898
119VEGF signaling pathway_Homo sapiens_hsa043700.43319205
120Amoebiasis_Homo sapiens_hsa051460.43316769
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43071149
122Thyroid hormone synthesis_Homo sapiens_hsa049180.38532817
123HIF-1 signaling pathway_Homo sapiens_hsa040660.38392821
124beta-Alanine metabolism_Homo sapiens_hsa004100.38332605
125Renal cell carcinoma_Homo sapiens_hsa052110.37778373
126Thyroid cancer_Homo sapiens_hsa052160.36500643
127Mineral absorption_Homo sapiens_hsa049780.34143420
128Long-term potentiation_Homo sapiens_hsa047200.32814478
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32570629
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.32554381
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31916715
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.29884504
133Renin-angiotensin system_Homo sapiens_hsa046140.28271301
134Bladder cancer_Homo sapiens_hsa052190.27661392
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.26824942
136Taste transduction_Homo sapiens_hsa047420.26648030

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