GOLGA5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.98540091
2positive regulation of gamma-delta T cell activation (GO:0046645)6.17519537
3microglial cell activation (GO:0001774)6.17185565
4positive regulation by symbiont of host defense response (GO:0052509)6.01923360
5modulation by symbiont of host defense response (GO:0052031)6.01923360
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.01923360
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.01923360
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.01923360
9modulation by symbiont of host immune response (GO:0052553)6.01923360
10regulation of B cell receptor signaling pathway (GO:0050855)5.90620781
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.72176795
12negative regulation of cell killing (GO:0031342)5.53457533
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.53457533
14positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.14395441
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.92066806
16macrophage activation (GO:0042116)4.85988485
17macrophage activation involved in immune response (GO:0002281)4.78341465
18hepatocyte apoptotic process (GO:0097284)4.65915641
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.60796736
20detection of external biotic stimulus (GO:0098581)4.55548826
21regulation of gamma-delta T cell differentiation (GO:0045586)4.51036333
22regulation of gamma-delta T cell activation (GO:0046643)4.47110896
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.40760333
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.33617871
25response to host immune response (GO:0052572)4.33617871
26negative T cell selection (GO:0043383)4.26068447
27neutrophil mediated immunity (GO:0002446)4.12374212
28regulation of interferon-beta biosynthetic process (GO:0045357)4.11565093
29positive T cell selection (GO:0043368)4.07280159
30response to host (GO:0075136)4.04280941
31response to host defenses (GO:0052200)4.04280941
32response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.04280941
33cellular extravasation (GO:0045123)4.01743848
34myeloid leukocyte mediated immunity (GO:0002444)4.00925799
35regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.97208135
36detection of biotic stimulus (GO:0009595)3.95558675
37negative regulation of interleukin-12 production (GO:0032695)3.90770868
38negative regulation of T cell mediated immunity (GO:0002710)3.90173511
39negative thymic T cell selection (GO:0045060)3.89287497
40regulation of interleukin-6 biosynthetic process (GO:0045408)3.85625751
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.78383901
42phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.76898245
43negative regulation of B cell proliferation (GO:0030889)3.76332903
44negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.74906148
45negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.73651514
46B cell receptor signaling pathway (GO:0050853)3.70314771
47regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.63022398
48regulation of necroptotic process (GO:0060544)3.62394165
49positive thymic T cell selection (GO:0045059)3.60257400
50positive regulation of granulocyte differentiation (GO:0030854)3.54840531
51histone H3-K36 demethylation (GO:0070544)3.48641235
52histone mRNA catabolic process (GO:0071044)3.48069240
53positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.45253944
54negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.34753185
55detection of other organism (GO:0098543)3.33551094
56response to interleukin-15 (GO:0070672)3.32947358
57activated T cell proliferation (GO:0050798)3.32356323
58interferon-gamma production (GO:0032609)3.31293644
59negative regulation of B cell mediated immunity (GO:0002713)3.29532046
60negative regulation of immunoglobulin mediated immune response (GO:0002890)3.29532046
61neutrophil activation involved in immune response (GO:0002283)3.28142453
62myeloid cell activation involved in immune response (GO:0002275)3.25835659
63response to peptidoglycan (GO:0032494)3.25203452
64leukocyte aggregation (GO:0070486)3.23903346
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23010929
66regulation of interleukin-12 biosynthetic process (GO:0045075)3.20381491
67negative regulation of adaptive immune response (GO:0002820)3.13669071
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12699837
69cellular response to interleukin-15 (GO:0071350)3.08428675
70positive regulation of interferon-alpha production (GO:0032727)3.07027407
71protein K11-linked deubiquitination (GO:0035871)3.06879266
72negative regulation of leukocyte mediated immunity (GO:0002704)3.04507609
73dopamine transport (GO:0015872)3.03707398
74respiratory burst (GO:0045730)3.03340257
75T cell migration (GO:0072678)3.03141548
76cellular response to ethanol (GO:0071361)3.01658380
77negative regulation of T-helper cell differentiation (GO:0045623)2.99844263
78negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99844263
79dosage compensation (GO:0007549)2.99645304
80antigen processing and presentation of endogenous antigen (GO:0019883)2.96809733
81T cell selection (GO:0045058)2.95814941
82regulation of B cell differentiation (GO:0045577)2.94731133
83regulation of beta-amyloid formation (GO:1902003)2.93886537
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88072092
85positive regulation of toll-like receptor signaling pathway (GO:0034123)2.86995282
86defense response to protozoan (GO:0042832)2.86497886
87regulation of regulatory T cell differentiation (GO:0045589)2.85556619
88regulation of interferon-alpha production (GO:0032647)2.83799838
89neutrophil activation (GO:0042119)2.83131283
90antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.82130557
91positive regulation of insulin receptor signaling pathway (GO:0046628)2.81804881
92T-helper 1 type immune response (GO:0042088)2.81510161
93I-kappaB phosphorylation (GO:0007252)2.80004340
94production of molecular mediator involved in inflammatory response (GO:0002532)2.79869309
95regulation of alpha-beta T cell proliferation (GO:0046640)2.78657578
96myeloid leukocyte activation (GO:0002274)2.78407380
97negative regulation of interleukin-17 production (GO:0032700)2.77461029
98B cell proliferation (GO:0042100)2.74376513
99dendritic cell migration (GO:0036336)2.71958952
100regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.70777144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.69187791
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.02325756
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.78392746
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.68733150
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.60820876
6RUNX_20019798_ChIP-Seq_JUKART_Human3.35534003
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.32371908
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.31800379
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21080727
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.98699828
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95175627
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93899718
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.86788225
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.77650648
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.68089137
16SCL_19346495_ChIP-Seq_HPC-7_Human2.54104925
17MYB_26560356_Chip-Seq_TH2_Human2.52438127
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.39237620
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28783592
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.27012978
21MYB_26560356_Chip-Seq_TH1_Human2.00496941
22SPI1_23127762_ChIP-Seq_K562_Human1.98038876
23GATA1_22025678_ChIP-Seq_K562_Human1.96031394
24VDR_24787735_ChIP-Seq_THP-1_Human1.93208723
25SPI1_23547873_ChIP-Seq_NB4_Human1.92691042
26GATA3_27048872_Chip-Seq_THYMUS_Human1.84446816
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77288630
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68913739
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64327324
30PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62061973
31PU_27001747_Chip-Seq_BMDM_Mouse1.58646917
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55113855
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53333179
34GATA3_26560356_Chip-Seq_TH2_Human1.52619292
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52492472
36VDR_24763502_ChIP-Seq_THP-1_Human1.49236177
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.46222249
38GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40579256
39MAF_26560356_Chip-Seq_TH1_Human1.40474270
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40426427
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36440409
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35361675
43NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35154424
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30806059
45GATA2_19941826_ChIP-Seq_K562_Human1.30135207
46GATA1_19941826_ChIP-Seq_K562_Human1.29735637
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28909076
48TP53_16413492_ChIP-PET_HCT116_Human1.25121613
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22574453
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21595070
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18324634
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.14637095
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12255091
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.11089589
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09660884
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07835806
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.07454149
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.07185557
59UTX_26944678_Chip-Seq_JUKART_Human1.06783004
60GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06317581
61KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.05126351
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04622344
63SMRT_27268052_Chip-Seq_Bcells_Human1.04138482
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02840432
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.02033005
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.00805646
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.00596248
68PRDM14_20953172_ChIP-Seq_ESCs_Human0.99802511
69ESR1_20079471_ChIP-ChIP_T-47D_Human0.99115795
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96069140
71TCF7_22412390_ChIP-Seq_EML_Mouse0.94024312
72ER_23166858_ChIP-Seq_MCF-7_Human0.93516836
73SALL4_22934838_ChIP-ChIP_CD34+_Human0.93136178
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92183510
75SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92002679
76OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91063921
77PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90587850
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90063595
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89934046
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89213230
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88530404
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.87054268
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86968297
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86749397
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85561422
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83296262
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82940896
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82387951
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82387951
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81865466
91AR_21572438_ChIP-Seq_LNCaP_Human0.80038857
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79396296
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79227231
94GATA3_26560356_Chip-Seq_TH1_Human0.78755181
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.77844665
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77765090
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.77351257
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.76837486
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.75894875
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.74959754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.69055901
2MP0003724_increased_susceptibility_to4.48090730
3MP0008260_abnormal_autophagy3.94545536
4MP0001835_abnormal_antigen_presentation3.42910976
5MP0003787_abnormal_imprinting2.96909515
6MP0001800_abnormal_humoral_immune2.73157520
7MP0003656_abnormal_erythrocyte_physiolo2.71905735
8MP0004381_abnormal_hair_follicle2.70225158
9MP0003763_abnormal_thymus_physiology2.64464779
10MP0003303_peritoneal_inflammation2.59689770
11MP0008057_abnormal_DNA_replication2.57293892
12MP0003436_decreased_susceptibility_to2.37956653
13MP0003172_abnormal_lysosome_physiology2.36343304
14MP0005671_abnormal_response_to2.24090632
15MP0000685_abnormal_immune_system2.23984218
16MP0002723_abnormal_immune_serum2.21269254
17MP0002419_abnormal_innate_immunity2.21017351
18MP0003183_abnormal_peptide_metabolism2.16414698
19MP0002166_altered_tumor_susceptibility2.13759353
20MP0000015_abnormal_ear_pigmentation2.12976371
21MP0005000_abnormal_immune_tolerance2.11825584
22MP0003300_gastrointestinal_ulcer2.09474087
23MP0009785_altered_susceptibility_to2.07939982
24MP0002452_abnormal_antigen_presenting2.07425964
25MP0005025_abnormal_response_to2.07274607
26MP0002420_abnormal_adaptive_immunity2.06164484
27MP0004883_abnormal_blood_vessel2.04571361
28MP0001819_abnormal_immune_cell2.03274381
29MP0005451_abnormal_body_composition1.98419273
30MP0005174_abnormal_tail_pigmentation1.96362910
31MP0002398_abnormal_bone_marrow1.86671867
32MP0001790_abnormal_immune_system1.83273635
33MP0005387_immune_system_phenotype1.83273635
34MP0005075_abnormal_melanosome_morpholog1.77825632
35MP0000716_abnormal_immune_system1.73048192
36MP0003828_pulmonary_edema1.70961925
37MP0002405_respiratory_system_inflammati1.70671144
38MP0008877_abnormal_DNA_methylation1.70285118
39MP0005464_abnormal_platelet_physiology1.68367711
40MP0003221_abnormal_cardiomyocyte_apopto1.66660884
41MP0000689_abnormal_spleen_morphology1.61992524
42MP0002722_abnormal_immune_system1.60210368
43MP0000703_abnormal_thymus_morphology1.60119498
44MP0005310_abnormal_salivary_gland1.45457347
45MP0006082_CNS_inflammation1.44541798
46MP0002148_abnormal_hypersensitivity_rea1.40916256
47MP0005164_abnormal_response_to1.39394611
48MP0003866_abnormal_defecation1.38559384
49MP0002006_tumorigenesis1.37132053
50MP0002429_abnormal_blood_cell1.33919110
51MP0004947_skin_inflammation1.33342660
52MP0004808_abnormal_hematopoietic_stem1.33105565
53MP0001845_abnormal_inflammatory_respons1.33079200
54MP0002332_abnormal_exercise_endurance1.27495870
55MP0009764_decreased_sensitivity_to1.23123728
56MP0000858_altered_metastatic_potential1.22759519
57MP0004484_altered_response_of1.20170095
58MP0002396_abnormal_hematopoietic_system1.17945240
59MP0001533_abnormal_skeleton_physiology1.17122514
60MP0003690_abnormal_glial_cell1.16520398
61MP0001545_abnormal_hematopoietic_system1.15109205
62MP0005397_hematopoietic_system_phenotyp1.15109205
63MP0004130_abnormal_muscle_cell1.14505699
64MP0001851_eye_inflammation1.07073719
65MP0000371_diluted_coat_color1.06618773
66MP0010155_abnormal_intestine_physiology1.04944570
67MP0002277_abnormal_respiratory_mucosa1.03851658
68MP0002132_abnormal_respiratory_system1.03137680
69MP0009333_abnormal_splenocyte_physiolog1.02487413
70MP0003191_abnormal_cellular_cholesterol1.00064073
71MP0002163_abnormal_gland_morphology0.94539715
72MP0000465_gastrointestinal_hemorrhage0.90651689
73MP0009278_abnormal_bone_marrow0.90073303
74MP0005408_hypopigmentation0.90062067
75MP0008469_abnormal_protein_level0.89268523
76MP0000604_amyloidosis0.89116747
77MP0003121_genomic_imprinting0.87227727
78MP0002998_abnormal_bone_remodeling0.85841766
79MP0003091_abnormal_cell_migration0.82196102
80MP0001853_heart_inflammation0.76797303
81MP0005376_homeostasis/metabolism_phenot0.76634513
82MP0001958_emphysema0.76483149
83MP0002009_preneoplasia0.72841332
84MP0003448_altered_tumor_morphology0.72704095
85MP0003632_abnormal_nervous_system0.70548930
86MP0001663_abnormal_digestive_system0.68976023
87MP0000427_abnormal_hair_cycle0.67592241
88MP0009763_increased_sensitivity_to0.66027611
89MP0009765_abnormal_xenobiotic_induced0.65438953
90MP0000249_abnormal_blood_vessel0.63792417
91MP0003195_calcinosis0.61292757
92MP0005409_darkened_coat_color0.60077881
93MP0005388_respiratory_system_phenotype0.59422905
94MP0002133_abnormal_respiratory_system0.59422905
95MP0003045_fibrosis0.59296424
96MP0008874_decreased_physiological_sensi0.59286789
97MP0003329_amyloid_beta_deposits0.59268785
98MP0002928_abnormal_bile_duct0.58999415
99MP0005266_abnormal_metabolism0.57428984
100MP0002019_abnormal_tumor_incidence0.56229325

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.45824696
2T lymphocytopenia (HP:0005403)5.82985775
3Recurrent bacterial skin infections (HP:0005406)5.72892424
4Abnormality of T cell number (HP:0011839)5.38671597
5Recurrent abscess formation (HP:0002722)5.01033188
6Eczematoid dermatitis (HP:0000976)4.68230239
7Retrobulbar optic neuritis (HP:0100654)4.59455915
8Optic neuritis (HP:0100653)4.59455915
9Gastrointestinal infarctions (HP:0005244)4.55720667
10Orchitis (HP:0100796)4.45330256
11Myositis (HP:0100614)4.29607637
12Recurrent fungal infections (HP:0002841)4.24760705
13Peritonitis (HP:0002586)4.06009159
14Gingival bleeding (HP:0000225)3.99800436
15Slow saccadic eye movements (HP:0000514)3.91491703
16Spontaneous hematomas (HP:0007420)3.87114266
17Recurrent skin infections (HP:0001581)3.83732313
18Recurrent cutaneous fungal infections (HP:0011370)3.62833324
19Chronic mucocutaneous candidiasis (HP:0002728)3.62833324
20Elevated erythrocyte sedimentation rate (HP:0003565)3.53792196
21Gingivitis (HP:0000230)3.52202986
22Keratoconjunctivitis sicca (HP:0001097)3.51516449
23Stomatitis (HP:0010280)3.50738822
24Recurrent gram-negative bacterial infections (HP:0005420)3.39134045
25Arterial thrombosis (HP:0004420)3.36956417
26Abnormality of T cells (HP:0002843)3.36125355
27Postural instability (HP:0002172)3.25282503
28Keratoconjunctivitis (HP:0001096)3.23891490
29Recurrent bronchitis (HP:0002837)3.20998923
30Leukocytosis (HP:0001974)3.15399957
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.08628539
32Recurrent viral infections (HP:0004429)3.03660861
33Chest pain (HP:0100749)3.03206628
34Mediastinal lymphadenopathy (HP:0100721)3.01620494
35Encephalitis (HP:0002383)3.00976455
36Abnormality of macrophages (HP:0004311)2.91101280
37Meningitis (HP:0001287)2.87347647
38Vasculitis (HP:0002633)2.81853742
39Visual hallucinations (HP:0002367)2.76161890
40Genetic anticipation (HP:0003743)2.74499921
41Hemoptysis (HP:0002105)2.70717034
42Periodontitis (HP:0000704)2.66869972
43Epistaxis (HP:0000421)2.63683842
44Subacute progressive viral hepatitis (HP:0006572)2.60401444
45Orthostatic hypotension (HP:0001278)2.58535003
46Resting tremor (HP:0002322)2.57208340
47Pelvic girdle muscle weakness (HP:0003749)2.55591929
48Abnormality of the peritoneum (HP:0002585)2.52247923
49Papillary thyroid carcinoma (HP:0002895)2.50737598
50Eosinophilia (HP:0001880)2.49819935
51Chronic obstructive pulmonary disease (HP:0006510)2.46003617
52Obstructive lung disease (HP:0006536)2.46003617
53Urticaria (HP:0001025)2.44552124
54Autoimmune hemolytic anemia (HP:0001890)2.44357130
55Abnormality of the vasculature of the conjunctiva (HP:0008054)2.42882454
56Conjunctival telangiectasia (HP:0000524)2.41983820
57Thyroiditis (HP:0100646)2.40267695
58Thoracolumbar scoliosis (HP:0002944)2.39860823
59Abnormality of eosinophils (HP:0001879)2.36933271
60Acute hepatic failure (HP:0006554)2.35620517
61Inflammation of the large intestine (HP:0002037)2.34331063
62Pulmonary infiltrates (HP:0002113)2.34250773
63Anorexia (HP:0002039)2.34055329
64Granulocytopenia (HP:0001913)2.33756117
65Pulmonary embolism (HP:0002204)2.33472850
66Prolonged bleeding time (HP:0003010)2.29533854
67Hypoplasia of the thymus (HP:0000778)2.27343845
68Fatigue (HP:0012378)2.23655127
69Hypochromic microcytic anemia (HP:0004840)2.17438486
70Gastrointestinal inflammation (HP:0004386)2.15695458
71Viral hepatitis (HP:0006562)2.14535650
72Microcytic anemia (HP:0001935)2.13764644
73Neoplasm of the tracheobronchial system (HP:0100552)2.10972699
74Colitis (HP:0002583)2.08902739
75Gangrene (HP:0100758)2.08470896
76Abnormality of the musculature of the pelvis (HP:0001469)2.06042784
77Abnormality of the hip-girdle musculature (HP:0001445)2.06042784
78Cellulitis (HP:0100658)2.02599238
79Poikilocytosis (HP:0004447)1.97586201
80Abnormality of the endocardium (HP:0004306)1.97548125
81Amaurosis fugax (HP:0100576)1.92342143
82Hemiplegia (HP:0002301)1.87507018
83Lymphopenia (HP:0001888)1.86100588
84Abnormality of the fingertips (HP:0001211)1.84872087
85Episodic fever (HP:0001954)1.83395443
86Glucose intolerance (HP:0000833)1.83300349
87Cerebral inclusion bodies (HP:0100314)1.82809386
88Papilledema (HP:0001085)1.81833540
89Bronchitis (HP:0012387)1.81703211
90IgG deficiency (HP:0004315)1.81616608
91Chronic diarrhea (HP:0002028)1.80959279
92Vertigo (HP:0002321)1.80646738
93Neurodegeneration (HP:0002180)1.80635957
94Panhypogammaglobulinemia (HP:0003139)1.80043405
95IgA deficiency (HP:0002720)1.79847329
96Stomach cancer (HP:0012126)1.79645365
97Abnormality of cells of the lymphoid lineage (HP:0012140)1.78413632
98Severe combined immunodeficiency (HP:0004430)1.77230362
99Ocular albinism (HP:0001107)1.76822979
100Thrombophlebitis (HP:0004418)1.75763430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.86285675
2BLK3.80665690
3GRK63.22059997
4TXK2.76377594
5TAOK32.68312721
6IRAK42.49006855
7IKBKE2.43381292
8MAP2K32.38134921
9FGR2.35267503
10CAMKK22.31194893
11CSK2.20992124
12FRK2.19097842
13MAP4K12.07309568
14JAK32.06897192
15TYK21.89569127
16PIK3CG1.79127609
17SYK1.77444961
18IRAK11.76742620
19FGFR31.76640203
20FES1.76627654
21MAP3K21.74712410
22MAP3K141.73717951
23IRAK21.71584836
24PTK2B1.67278233
25SGK21.62982282
26STK41.58346961
27BTK1.57449633
28JAK11.56473181
29WNK11.55705494
30GRK51.55431677
31BMPR21.50591386
32KSR21.47351494
33MAP3K131.29835191
34TEC1.25667455
35ZAP701.25331882
36HCK1.25008292
37MAP3K31.23213070
38SGK31.23028817
39KSR11.23020995
40YES11.20928529
41JAK21.20345769
42ITK1.19494836
43LYN1.16009640
44MAP3K11.14838186
45PLK21.13362675
46RAF11.12001201
47NLK1.06193659
48LRRK21.04688350
49PIM11.02806246
50ERBB20.98199357
51MARK30.96979417
52PRPF4B0.94998483
53ACVR1B0.92545008
54LCK0.92237523
55SGK2230.91699568
56SGK4940.91699568
57CAMK1D0.90212881
58MARK20.88717829
59DYRK1A0.86172653
60CAMKK10.83247953
61MAP3K60.83008226
62PAK30.82665067
63MATK0.81964256
64CDK120.78835435
65STK380.78172127
66EPHB10.75673927
67FGFR40.73932933
68RIPK10.69394905
69CAMK40.68605951
70TAOK10.68341238
71IKBKB0.66347249
72TBK10.64002122
73STK110.62468897
74STK100.62025852
75PDK10.61841076
76MAP3K50.61206134
77TGFBR20.59384383
78SGK10.58875618
79MAP3K70.56039020
80MAP3K110.51742692
81NEK60.50358302
82EGFR0.49404045
83DYRK30.49348901
84CAMK1G0.49154792
85TAF10.47392240
86KIT0.46944252
87MAP2K40.43574074
88FYN0.43516469
89ADRBK10.43387216
90CSF1R0.42835552
91RET0.42295264
92CHUK0.42240229
93BRD40.40257970
94PRKCQ0.36863131
95MAP3K100.36809714
96FGFR20.36342401
97TRPM70.34838327
98PRKAA20.32765712
99MELK0.32641799
100PDGFRB0.31611888

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.93756472
2Osteoclast differentiation_Homo sapiens_hsa043802.55255208
3B cell receptor signaling pathway_Homo sapiens_hsa046622.50309718
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23761899
5T cell receptor signaling pathway_Homo sapiens_hsa046602.23258022
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.22882768
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.17525255
8Non-small cell lung cancer_Homo sapiens_hsa052232.11613053
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.09199397
10Tuberculosis_Homo sapiens_hsa051522.08691727
11Measles_Homo sapiens_hsa051621.99040599
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.96134565
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89649731
14Staphylococcus aureus infection_Homo sapiens_hsa051501.85156481
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81790209
16Primary immunodeficiency_Homo sapiens_hsa053401.78553350
17Dorso-ventral axis formation_Homo sapiens_hsa043201.66958611
18Malaria_Homo sapiens_hsa051441.65135172
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.65070360
20Acute myeloid leukemia_Homo sapiens_hsa052211.63801463
21Legionellosis_Homo sapiens_hsa051341.55117208
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54132368
23Influenza A_Homo sapiens_hsa051641.52311342
24Chemokine signaling pathway_Homo sapiens_hsa040621.49810620
25Prolactin signaling pathway_Homo sapiens_hsa049171.46817504
26Toxoplasmosis_Homo sapiens_hsa051451.45855077
27Hematopoietic cell lineage_Homo sapiens_hsa046401.44927881
28Hepatitis B_Homo sapiens_hsa051611.44632780
29TNF signaling pathway_Homo sapiens_hsa046681.41911123
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37232656
31FoxO signaling pathway_Homo sapiens_hsa040681.34685711
32Pancreatic cancer_Homo sapiens_hsa052121.33402474
33Hepatitis C_Homo sapiens_hsa051601.27711824
34Endometrial cancer_Homo sapiens_hsa052131.23330014
35Platelet activation_Homo sapiens_hsa046111.22517068
36Graft-versus-host disease_Homo sapiens_hsa053321.20854733
37Renal cell carcinoma_Homo sapiens_hsa052111.19634589
38Chronic myeloid leukemia_Homo sapiens_hsa052201.18165743
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17616464
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.10532081
41Apoptosis_Homo sapiens_hsa042101.10329421
42VEGF signaling pathway_Homo sapiens_hsa043701.09787884
43Herpes simplex infection_Homo sapiens_hsa051681.09554993
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07537768
45Allograft rejection_Homo sapiens_hsa053301.06804551
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.04200060
47Autoimmune thyroid disease_Homo sapiens_hsa053201.02902886
48mTOR signaling pathway_Homo sapiens_hsa041501.02621502
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02102431
50Inositol phosphate metabolism_Homo sapiens_hsa005621.01126571
51Glioma_Homo sapiens_hsa052140.97181171
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.87232686
53Prostate cancer_Homo sapiens_hsa052150.87137039
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86892813
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85083844
56ErbB signaling pathway_Homo sapiens_hsa040120.84925048
57Long-term potentiation_Homo sapiens_hsa047200.79159812
58Phagosome_Homo sapiens_hsa041450.78652020
59Choline metabolism in cancer_Homo sapiens_hsa052310.75176234
60GnRH signaling pathway_Homo sapiens_hsa049120.73790239
61Antigen processing and presentation_Homo sapiens_hsa046120.73539142
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71861260
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71524585
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.70966607
65Viral carcinogenesis_Homo sapiens_hsa052030.70276085
66HIF-1 signaling pathway_Homo sapiens_hsa040660.70215973
67Notch signaling pathway_Homo sapiens_hsa043300.69626488
68Colorectal cancer_Homo sapiens_hsa052100.68897165
69Type I diabetes mellitus_Homo sapiens_hsa049400.68469556
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68437794
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.67696856
72Type II diabetes mellitus_Homo sapiens_hsa049300.67498721
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67093927
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66854730
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66305348
76African trypanosomiasis_Homo sapiens_hsa051430.64873716
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64735969
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64601271
79MAPK signaling pathway_Homo sapiens_hsa040100.62558546
80Insulin resistance_Homo sapiens_hsa049310.61131148
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.58373529
82Pertussis_Homo sapiens_hsa051330.58095787
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57438617
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57292553
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55975015
86Thyroid cancer_Homo sapiens_hsa052160.54370440
87Estrogen signaling pathway_Homo sapiens_hsa049150.52937430
88Cholinergic synapse_Homo sapiens_hsa047250.52268376
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51933366
90MicroRNAs in cancer_Homo sapiens_hsa052060.50804800
91Epstein-Barr virus infection_Homo sapiens_hsa051690.50413069
92Regulation of autophagy_Homo sapiens_hsa041400.49753535
93Fatty acid biosynthesis_Homo sapiens_hsa000610.49633165
94Small cell lung cancer_Homo sapiens_hsa052220.48283149
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45496891
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45249693
97HTLV-I infection_Homo sapiens_hsa051660.42976894
98Shigellosis_Homo sapiens_hsa051310.42102775
99Viral myocarditis_Homo sapiens_hsa054160.41981301
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40663969

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