ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	8.97755817
2	axonemal dynein complex assembly (GO:0070286)	8.25770021
3	chromosome condensation (GO:0030261)	7.63448580
4	plasma membrane fusion (GO:0045026)	7.55374347
5	single strand break repair (GO:0000012)	7.53604294
6	spermatid development (GO:0007286)	7.45947235
7	DNA packaging (GO:0006323)	7.44401084
8	response to pheromone (GO:0019236)	7.40349997
9	centriole replication (GO:0007099)	7.38496800
10	epithelial cilium movement (GO:0003351)	7.05342856
11	multicellular organism reproduction (GO:0032504)	7.04757832
12	cilium or flagellum-dependent cell motility (GO:0001539)	6.99636642
13	microtubule depolymerization (GO:0007019)	6.95941370
14	sperm-egg recognition (GO:0035036)	6.91355947
15	protein targeting to Golgi (GO:0000042)	6.85837371
16	establishment of protein localization to Golgi (GO:0072600)	6.83155046
17	spermatid nucleus differentiation (GO:0007289)	6.61217452
18	motile cilium assembly (GO:0044458)	6.60835437
19	microtubule polymerization or depolymerization (GO:0031109)	6.45394717
20	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.44189999
21	reproduction (GO:0000003)	6.28922015
22	protein polyglutamylation (GO:0018095)	6.25227705
23	microtubule severing (GO:0051013)	6.17907737
24	calcium ion-dependent exocytosis (GO:0017156)	6.11579677
25	centriole assembly (GO:0098534)	6.10718460
26	cilium movement (GO:0003341)	6.10174910
27	spermatogenesis (GO:0007283)	6.03952773
28	male gamete generation (GO:0048232)	6.01771869
29	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.96235265
30	binding of sperm to zona pellucida (GO:0007339)	5.84502932
31	rRNA methylation (GO:0031167)	5.76304235
32	cell-cell recognition (GO:0009988)	5.70017665
33	gamete generation (GO:0007276)	5.52496968
34	phosphatidylethanolamine metabolic process (GO:0046337)	5.47371493
35	regulation of Rab GTPase activity (GO:0032313)	5.31706938
36	positive regulation of Rab GTPase activity (GO:0032851)	5.31706938
37	negative regulation of inclusion body assembly (GO:0090084)	5.22064686
38	regulation of cilium movement (GO:0003352)	5.14339918
39	sexual reproduction (GO:0019953)	5.14223334
40	regulation of centriole replication (GO:0046599)	5.13992227
41	single fertilization (GO:0007338)	5.11244894
42	protein localization to Golgi apparatus (GO:0034067)	5.08440314
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.84102296
44	rRNA modification (GO:0000154)	4.82070685
45	regulation of transcription involved in cell fate commitment (GO:0060850)	4.78410507
46	cellular ketone body metabolic process (GO:0046950)	4.63625160
47	fertilization (GO:0009566)	4.48695335
48	multicellular organismal reproductive process (GO:0048609)	4.37418696
49	RNA destabilization (GO:0050779)	4.36644894
50	germ cell development (GO:0007281)	4.32985699
51	seminiferous tubule development (GO:0072520)	4.26402682
52	cell wall macromolecule metabolic process (GO:0044036)	4.16654994
53	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.12298557
54	ketone body metabolic process (GO:1902224)	4.05652249
55	cell wall macromolecule catabolic process (GO:0016998)	4.00856071
56	musculoskeletal movement (GO:0050881)	3.89810214
57	multicellular organismal movement (GO:0050879)	3.89810214
58	organic cation transport (GO:0015695)	3.78840620
59	chromatin silencing (GO:0006342)	3.77057878
60	axoneme assembly (GO:0035082)	3.72631130
61	microtubule nucleation (GO:0007020)	3.71265278
62	nucleus organization (GO:0006997)	3.61818412
63	regulation of inclusion body assembly (GO:0090083)	3.57877364
64	glomerular visceral epithelial cell development (GO:0072015)	3.54728664
65	glomerular epithelial cell development (GO:0072310)	3.53725640
66	regulation of microtubule-based movement (GO:0060632)	3.47117193
67	coenzyme catabolic process (GO:0009109)	3.41541786
68	negative regulation of Rho protein signal transduction (GO:0035024)	3.36861628
69	membrane protein intracellular domain proteolysis (GO:0031293)	3.18196820
70	Golgi to endosome transport (GO:0006895)	3.14505178
71	ventricular system development (GO:0021591)	3.12763123
72	cerebral cortex neuron differentiation (GO:0021895)	3.07730564
73	peptidyl-threonine dephosphorylation (GO:0035970)	3.06250913
74	response to acidic pH (GO:0010447)	3.04951445
75	male meiosis I (GO:0007141)	2.99507258
76	cellular response to pH (GO:0071467)	2.98602778
77	cilium assembly (GO:0042384)	2.95964034
78	cilium organization (GO:0044782)	2.95222655
79	negative regulation of histone methylation (GO:0031061)	2.92186310
80	lateral ventricle development (GO:0021670)	2.87244016
81	polyamine biosynthetic process (GO:0006596)	2.86562179
82	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.86455224
83	cell recognition (GO:0008037)	2.82794193
84	multicellular organismal development (GO:0007275)	2.80959462
85	glycerol ether metabolic process (GO:0006662)	2.77010931
86	urinary tract smooth muscle contraction (GO:0014848)	2.73786552
87	left/right axis specification (GO:0070986)	2.72407797
88	vesicle transport along microtubule (GO:0047496)	2.71966527
89	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.71756159
90	regulation of histone H3-K27 methylation (GO:0061085)	2.71129200
91	spinal cord motor neuron differentiation (GO:0021522)	2.70726642
92	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.65975166
93	protein-DNA complex disassembly (GO:0032986)	2.63923931
94	nucleosome disassembly (GO:0006337)	2.63923931
95	regulation of interleukin-13 production (GO:0032656)	2.63099689
96	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.63047849
97	piRNA metabolic process (GO:0034587)	2.60731690
98	sperm motility (GO:0030317)	11.3605910
99	acrosome reaction (GO:0007340)	10.5832251
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.0344554

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.63601460
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.02494645
3	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.93273521
4	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.93273521
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.91951000
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.61345538
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.53689921
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.38818920
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.34761129
10	CBP_20019798_ChIP-Seq_JUKART_Human	2.34761129
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.29826749
12	FUS_26573619_Chip-Seq_HEK293_Human	2.27697050
13	DROSHA_22980978_ChIP-Seq_HELA_Human	2.22511596
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.98433521
15	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.91530400
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.85724178
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.82017597
18	P300_19829295_ChIP-Seq_ESCs_Human	1.80641153
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.77039796
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73302649
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72559639
22	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.69143144
23	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.67810424
24	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.64982765
25	NANOG_20526341_ChIP-Seq_ESCs_Human	1.62732524
26	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.57691776
27	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.53051054
28	ERA_21632823_ChIP-Seq_H3396_Human	1.52969140
29	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52796682
30	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.52540028
31	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.51712048
32	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.50115297
33	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48144395
34	MYC_19829295_ChIP-Seq_ESCs_Human	1.47051987
35	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.46550106
36	TAF2_19829295_ChIP-Seq_ESCs_Human	1.46543101
37	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.45377006
38	RAC3_21632823_ChIP-Seq_H3396_Human	1.44819016
39	AR_25329375_ChIP-Seq_VCAP_Human	1.43563458
40	TP53_18474530_ChIP-ChIP_U2OS_Human	1.42961017
41	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.42395995
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.42034888
43	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.41973674
44	STAT3_23295773_ChIP-Seq_U87_Human	1.41702689
45	CTCF_27219007_Chip-Seq_Bcells_Human	1.40669249
46	ZNF274_21170338_ChIP-Seq_K562_Hela	1.38896345
47	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35128917
48	GBX2_23144817_ChIP-Seq_PC3_Human	1.34242105
49	CEBPB_22108803_ChIP-Seq_LS180_Human	1.32855649
50	ETV1_20927104_ChIP-Seq_GIST48_Human	1.29990201
51	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.29515977
52	TBL1_22424771_ChIP-Seq_293T_Human	1.28855525
53	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.28681729
54	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28452733
55	RBPJ_21746931_ChIP-Seq_IB4_Human	1.28440809
56	OCT4_20526341_ChIP-Seq_ESCs_Human	1.27891630
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27883502
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27883502
59	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.27599316
60	ERG_20517297_ChIP-Seq_VCAP_Human	1.25794550
61	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.25673738
62	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.24347387
63	AR_21572438_ChIP-Seq_LNCaP_Human	1.23812112
64	NFYB_21822215_ChIP-Seq_K562_Human	1.22726803
65	E2F1_20622854_ChIP-Seq_HELA_Human	1.21716783
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20921560
67	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19724966
68	SMC4_20622854_ChIP-Seq_HELA_Human	1.19126448
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19072221
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18073039
71	CTCF_20526341_ChIP-Seq_ESCs_Human	1.17189987
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16349585
73	PHF8_20622853_ChIP-Seq_HELA_Human	1.15900850
74	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.15756819
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15735226
76	SMRT_27268052_Chip-Seq_Bcells_Human	1.15311753
77	BCL6_27268052_Chip-Seq_Bcells_Human	1.15138301
78	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.14594227
79	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.13233074
80	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.12829338
81	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.12656975
82	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.12360208
83	TCF4_23295773_ChIP-Seq_U87_Human	1.12186088
84	GF1_26923725_Chip-Seq_HPCs_Mouse	1.11965282
85	P53_21459846_ChIP-Seq_SAOS-2_Human	1.11719253
86	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.11702669
87	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11545147
88	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11285639
89	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.10395185
90	TP63_22573176_ChIP-Seq_HFKS_Human	1.09506734
91	P300_27268052_Chip-Seq_Bcells_Human	1.07250786
92	PHF8_20622854_ChIP-Seq_HELA_Human	1.07167948
93	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.06115809
94	NFYA_21822215_ChIP-Seq_K562_Human	1.05746658
95	BCOR_27268052_Chip-Seq_Bcells_Human	1.05532768
96	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.05433237
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05188484
98	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05188484
99	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.05182875
100	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04767525

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	6.10522014
2	MP0005377_hearing/vestibular/ear_phenot	6.10522014
3	MP0005670_abnormal_white_adipose	4.47282648
4	MP0003698_abnormal_male_reproductive	4.02708936
5	MP0001929_abnormal_gametogenesis	3.52150736
6	MP0001348_abnormal_lacrimal_gland	3.05710605
7	MP0003879_abnormal_hair_cell	2.39801884
8	MP0002161_abnormal_fertility/fecundity	2.29121268
9	MP0003718_maternal_effect	2.13680894
10	MP0001485_abnormal_pinna_reflex	2.12887649
11	MP0005410_abnormal_fertilization	10.6089407
12	MP0001486_abnormal_startle_reflex	1.79773192
13	MP0003646_muscle_fatigue	1.77560136
14	MP0002132_abnormal_respiratory_system	1.73413461
15	MP0009053_abnormal_anal_canal	1.72026000
16	MP0002210_abnormal_sex_determination	1.71208536
17	MP0000678_abnormal_parathyroid_gland	1.65648463
18	MP0005423_abnormal_somatic_nervous	1.63505452
19	MP0008877_abnormal_DNA_methylation	1.62886600
20	MP0002249_abnormal_larynx_morphology	1.62744455
21	MP0001968_abnormal_touch/_nociception	1.45997823
22	MP0002234_abnormal_pharynx_morphology	1.40336486
23	MP0002822_catalepsy	1.37434858
24	MP0001145_abnormal_male_reproductive	1.33408250
25	MP0000653_abnormal_sex_gland	1.32358446
26	MP0000026_abnormal_inner_ear	1.30409856
27	MP0002138_abnormal_hepatobiliary_system	1.29773957
28	MP0004742_abnormal_vestibular_system	1.28865138
29	MP0001963_abnormal_hearing_physiology	1.27252064
30	MP0002282_abnormal_trachea_morphology	1.22190693
31	MP0001984_abnormal_olfaction	1.20128233
32	MP0005379_endocrine/exocrine_gland_phen	1.16368895
33	MP0005551_abnormal_eye_electrophysiolog	1.14626825
34	MP0004859_abnormal_synaptic_plasticity	1.14422756
35	MP0008961_abnormal_basal_metabolism	1.12473556
36	MP0000534_abnormal_ureter_morphology	1.03124768
37	MP0005451_abnormal_body_composition	1.01350282
38	MP0005310_abnormal_salivary_gland	1.00326466
39	MP0009745_abnormal_behavioral_response	0.95028966
40	MP0002735_abnormal_chemical_nociception	0.90886591
41	MP0002572_abnormal_emotion/affect_behav	0.90494054
42	MP0005253_abnormal_eye_physiology	0.88749156
43	MP0002653_abnormal_ependyma_morphology	0.88198333
44	MP0002734_abnormal_mechanical_nocicepti	0.87325455
45	MP0002736_abnormal_nociception_after	0.87195252
46	MP0006276_abnormal_autonomic_nervous	0.87079822
47	MP0003011_delayed_dark_adaptation	0.87056285
48	MP0005395_other_phenotype	0.86933137
49	MP0001765_abnormal_ion_homeostasis	0.86550866
50	MP0000955_abnormal_spinal_cord	0.86222710
51	MP0002127_abnormal_cardiovascular_syste	0.85777381
52	MP0002067_abnormal_sensory_capabilities	0.84700937
53	MP0009697_abnormal_copulation	0.84192933
54	MP0003119_abnormal_digestive_system	0.83945962
55	MP0000566_synostosis	0.83943155
56	MP0002272_abnormal_nervous_system	0.83761419
57	MP0006292_abnormal_olfactory_placode	0.82841443
58	MP0002557_abnormal_social/conspecific_i	0.78015954
59	MP0000049_abnormal_middle_ear	0.76166697
60	MP0000516_abnormal_urinary_system	0.76052877
61	MP0005367_renal/urinary_system_phenotyp	0.76052877
62	MP0002229_neurodegeneration	0.75770553
63	MP0005085_abnormal_gallbladder_physiolo	0.71907683
64	MP0004085_abnormal_heartbeat	0.69991860
65	MP0001293_anophthalmia	0.68094593
66	MP0009115_abnormal_fat_cell	0.66151000
67	MP0001666_abnormal_nutrient_absorption	0.66134909
68	MP0002928_abnormal_bile_duct	0.64647648
69	MP0001905_abnormal_dopamine_level	0.64274950
70	MP0008995_early_reproductive_senescence	0.63746801
71	MP0001440_abnormal_grooming_behavior	0.63402936
72	MP0008569_lethality_at_weaning	0.63260555
73	MP0001970_abnormal_pain_threshold	0.61304000
74	MP0005666_abnormal_adipose_tissue	0.59966087
75	MP0003183_abnormal_peptide_metabolism	0.59607064
76	MP0002102_abnormal_ear_morphology	0.59157663
77	MP0005248_abnormal_Harderian_gland	0.57672983
78	MP0003635_abnormal_synaptic_transmissio	0.55186383
79	MP0002733_abnormal_thermal_nociception	0.54390448
80	MP0005167_abnormal_blood-brain_barrier	0.52981290
81	MP0005365_abnormal_bile_salt	0.52255054
82	MP0005391_vision/eye_phenotype	0.51109344
83	MP0010329_abnormal_lipoprotein_level	0.50171804
84	MP0001501_abnormal_sleep_pattern	0.47314330
85	MP0008789_abnormal_olfactory_epithelium	0.46935933
86	MP0005375_adipose_tissue_phenotype	0.45399414
87	MP0005623_abnormal_meninges_morphology	0.45278389
88	MP0000230_abnormal_systemic_arterial	0.44831919
89	MP0003950_abnormal_plasma_membrane	0.44233233
90	MP0002064_seizures	0.42508724
91	MP0002184_abnormal_innervation	0.42386833
92	MP0003699_abnormal_female_reproductive	0.42029853
93	MP0005394_taste/olfaction_phenotype	0.42015462
94	MP0005499_abnormal_olfactory_system	0.42015462
95	MP0003077_abnormal_cell_cycle	0.41468710
96	MP0003861_abnormal_nervous_system	0.40240205
97	MP0003938_abnormal_ear_development	0.39775650
98	MP0003633_abnormal_nervous_system	0.39689958
99	MP0003136_yellow_coat_color	0.39167991
100	MP0004484_altered_response_of	0.38934584

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	7.98260183
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.98260183
3	Abnormal ciliary motility (HP:0012262)	6.61456110
4	Abnormal respiratory motile cilium physiology (HP:0012261)	6.24090952
5	Severe visual impairment (HP:0001141)	6.15836994
6	Abnormal respiratory motile cilium morphology (HP:0005938)	5.78879265
7	Abnormal respiratory epithelium morphology (HP:0012253)	5.78879265
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.49134511
9	Tubulointerstitial nephritis (HP:0001970)	5.04716237
10	Asymmetric septal hypertrophy (HP:0001670)	4.88354300
11	Chronic hepatic failure (HP:0100626)	4.87763003
12	Infertility (HP:0000789)	4.75360319
13	Nasal polyposis (HP:0100582)	4.46904009
14	Bony spicule pigmentary retinopathy (HP:0007737)	4.40423103
15	Male infertility (HP:0003251)	4.28940109
16	Rhinitis (HP:0012384)	4.17356317
17	Attenuation of retinal blood vessels (HP:0007843)	4.11029129
18	Nephronophthisis (HP:0000090)	3.98764779
19	Bell-shaped thorax (HP:0001591)	3.83048343
20	Type II lissencephaly (HP:0007260)	3.80058979
21	Hyperkalemia (HP:0002153)	3.72656434
22	Abnormality of the nasal mucosa (HP:0000433)	3.53016580
23	Cone-rod dystrophy (HP:0000548)	3.33650474
24	Progressive cerebellar ataxia (HP:0002073)	3.21198985
25	Resting tremor (HP:0002322)	3.19111038
26	Hypoplastic ischia (HP:0003175)	3.17245195
27	Abnormality of the renal medulla (HP:0100957)	3.13900269
28	Abnormality of macular pigmentation (HP:0008002)	3.10655149
29	Bronchiectasis (HP:0002110)	3.10393878
30	Chronic bronchitis (HP:0004469)	3.08443739
31	Impulsivity (HP:0100710)	3.06935577
32	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.05335013
33	Abnormal rod and cone electroretinograms (HP:0008323)	3.02798608
34	Potter facies (HP:0002009)	2.92695366
35	Facial shape deformation (HP:0011334)	2.92695366
36	Hypoplasia of the thymus (HP:0000778)	2.92335350
37	Tubulointerstitial abnormality (HP:0001969)	2.90606781
38	Stage 5 chronic kidney disease (HP:0003774)	2.87353765
39	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.87287961
40	Hypoalphalipoproteinemia (HP:0003233)	2.86641166
41	Amelogenesis imperfecta (HP:0000705)	2.78415230
42	Abnormality of the ischium (HP:0003174)	2.76759564
43	Azoospermia (HP:0000027)	2.76539165
44	Postural instability (HP:0002172)	2.75158421
45	Abnormal spermatogenesis (HP:0008669)	2.73432072
46	Retinal dysplasia (HP:0007973)	2.66189237
47	Tubular atrophy (HP:0000092)	2.49039744
48	Generalized aminoaciduria (HP:0002909)	2.45967786
49	Abnormal drinking behavior (HP:0030082)	2.45714904
50	Polydipsia (HP:0001959)	2.45714904
51	Abnormal connection of the cardiac segments (HP:0011545)	2.44941107
52	Abnormal ventriculo-arterial connection (HP:0011563)	2.44941107
53	Transposition of the great arteries (HP:0001669)	2.44941107
54	Enlarged epiphyses (HP:0010580)	2.44359777
55	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.42431303
56	Abnormal urine output (HP:0012590)	2.42312233
57	Abnormality of dental color (HP:0011073)	2.41994310
58	Portal hypertension (HP:0001409)	2.38556859
59	Occipital encephalocele (HP:0002085)	2.38011558
60	Myokymia (HP:0002411)	2.28249675
61	Menstrual irregularities (HP:0000858)	2.21312083
62	Abnormality of the hepatic vasculature (HP:0006707)	2.19993647
63	Calf muscle hypertrophy (HP:0008981)	2.18093843
64	Abnormality of abdominal situs (HP:0011620)	2.13503122
65	Abdominal situs inversus (HP:0003363)	2.13503122
66	Pancreatic cysts (HP:0001737)	2.12369150
67	Muscle hypertrophy of the lower extremities (HP:0008968)	2.11637264
68	Abnormality of potassium homeostasis (HP:0011042)	2.10672923
69	Truncal obesity (HP:0001956)	2.09820829
70	Intellectual disability, moderate (HP:0002342)	2.08870414
71	Polyuria (HP:0000103)	2.05855581
72	Progressive sensorineural hearing impairment (HP:0000408)	2.05588190
73	Abnormality of renal excretion (HP:0011036)	2.02955795
74	Epiphyseal dysplasia (HP:0002656)	2.01499481
75	Renovascular hypertension (HP:0100817)	1.98412168
76	Pancreatic fibrosis (HP:0100732)	1.97710712
77	Abnormality of the vitreous humor (HP:0004327)	1.95608207
78	Chronic sinusitis (HP:0011109)	1.95090836
79	Midline defect of the nose (HP:0004122)	1.93875417
80	Hyperuricemia (HP:0002149)	1.83432201
81	Increased purine levels (HP:0004368)	1.83432201
82	Genetic anticipation (HP:0003743)	1.82325299
83	Osteomalacia (HP:0002749)	1.81063077
84	Cystic liver disease (HP:0006706)	1.77361977
85	Optic nerve hypoplasia (HP:0000609)	1.76883675
86	Focal segmental glomerulosclerosis (HP:0000097)	1.76790335
87	Insulin-resistant diabetes mellitus (HP:0000831)	1.76667291
88	Renal Fanconi syndrome (HP:0001994)	1.76487063
89	Unilateral renal agenesis (HP:0000122)	1.74628291
90	Abnormality of the aortic arch (HP:0012303)	1.72324553
91	Poor coordination (HP:0002370)	1.71713147
92	Cerebellar dysplasia (HP:0007033)	1.71044264
93	Abnormality of the pubic bones (HP:0003172)	1.69608047
94	Decreased central vision (HP:0007663)	1.67216362
95	Hypophosphatemic rickets (HP:0004912)	1.66097031
96	Renal dysplasia (HP:0000110)	1.65672517
97	Recurrent pneumonia (HP:0006532)	1.62317462
98	Medial flaring of the eyebrow (HP:0010747)	1.61954935
99	Gait imbalance (HP:0002141)	1.61511618
100	Congenital malformation of the right heart (HP:0011723)	1.61366823

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.36979312
2	BRD4	4.00625595
3	DDR2	3.89784505
4	TESK1	3.81669718
5	INSRR	3.69725406
6	PLK2	3.16095218
7	MAP4K2	3.10988690
8	CDK19	2.97976863
9	STK38L	2.97308760
10	MAPK15	2.95198928
11	PNCK	2.70617402
12	STK38	2.57117553
13	CDK12	2.36158935
14	TAF1	2.00019039
15	PIK3CG	1.82049139
16	CAMK1G	1.72670616
17	FRK	1.60346943
18	MAP3K9	1.45072259
19	ARAF	1.39216961
20	NTRK3	1.34256916
21	NEK6	1.34033601
22	PRKD3	1.29528414
23	PDPK1	1.28622486
24	PDK1	1.27954738
25	PTK2B	1.15172802
26	DYRK1B	1.14044933
27	WNK1	1.13159055
28	LATS2	1.11517859
29	MST1R	1.10650787
30	LATS1	1.05326133
31	MAP3K4	1.04593633
32	CDK7	0.96918591
33	MARK1	0.91801346
34	BRAF	0.88838154
35	KSR2	0.85590211
36	MAP2K7	0.75517888
37	PRKG1	0.73040084
38	TYRO3	0.72364716
39	MAP3K2	0.67113904
40	CDK3	0.66824148
41	PRKG2	0.62444239
42	SIK2	0.60573402
43	BRSK2	0.59790518
44	PRKCG	0.59018647
45	MAP2K4	0.54561538
46	RPS6KA2	0.51435419
47	RPS6KA1	0.50287599
48	ROCK1	0.49023975
49	ADRBK2	0.45372869
50	TIE1	0.45105206
51	CDK2	0.43054548
52	SGK494	0.42996612
53	SGK223	0.42996612
54	NTRK2	0.42126018
55	GSK3B	0.41027093
56	TNIK	0.40545845
57	ACVR1B	0.40120672
58	MAP3K6	0.39163182
59	CDK1	0.38814123
60	PRKAA2	0.36055935
61	STK39	0.35740296
62	CAMK1	0.35695008
63	OBSCN	0.35479579
64	MAPK1	0.34767185
65	PRKCZ	0.34534487
66	CAMK1D	0.32850833
67	MUSK	0.31615519
68	CDK9	0.31318912
69	AKT3	0.31292865
70	PRKCB	0.30712637
71	TLK1	0.30538711
72	BRSK1	0.29170522
73	MAPK8	0.28491008
74	MOS	0.28403347
75	RPS6KA4	0.27505032
76	UHMK1	0.27184064
77	BMPR1B	0.27054774
78	MAP3K11	0.24749571
79	MAPK14	0.24736078
80	CHEK1	0.24503903
81	MTOR	0.24472686
82	NUAK1	0.23632802
83	MINK1	0.23592121
84	SGK1	0.23570445
85	STK3	0.22192029
86	OXSR1	0.21373400
87	DYRK3	0.21362688
88	MAPK10	0.20639887
89	PRKACB	0.20080509
90	WNK4	0.19989737
91	MAP3K13	0.19436667
92	MAP3K1	0.18640915
93	MAP2K6	0.18251553
94	MAP3K8	0.16808929
95	MKNK2	0.16475393
96	MAPK11	0.14736587
97	RPS6KA6	0.14613171
98	CAMK2A	0.14058273
99	PRKAA1	0.13871549
100	TRPM7	0.13595758

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.77640212
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.94379125
3	Olfactory transduction_Homo sapiens_hsa04740	3.88897120
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.61969903
5	Butanoate metabolism_Homo sapiens_hsa00650	2.55877434
6	Phenylalanine metabolism_Homo sapiens_hsa00360	2.07137831
7	Fatty acid degradation_Homo sapiens_hsa00071	1.89013239
8	Taste transduction_Homo sapiens_hsa04742	1.82267239
9	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.77691545
10	Nicotine addiction_Homo sapiens_hsa05033	1.77576614
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.63098529
12	Phototransduction_Homo sapiens_hsa04744	1.61040787
13	RNA transport_Homo sapiens_hsa03013	1.58336424
14	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.52612423
15	Retinol metabolism_Homo sapiens_hsa00830	1.51023708
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.46893408
17	Type II diabetes mellitus_Homo sapiens_hsa04930	1.40661230
18	Arginine and proline metabolism_Homo sapiens_hsa00330	1.29749129
19	ABC transporters_Homo sapiens_hsa02010	1.28884336
20	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.27818710
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22899968
22	Tyrosine metabolism_Homo sapiens_hsa00350	1.19918947
23	Calcium signaling pathway_Homo sapiens_hsa04020	1.19049778
24	Caffeine metabolism_Homo sapiens_hsa00232	1.18872120
25	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.18818960
26	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.18619822
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.14666057
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.13363773
29	Oocyte meiosis_Homo sapiens_hsa04114	1.09071050
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.08515952
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.06942226
32	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.04668216
33	Protein digestion and absorption_Homo sapiens_hsa04974	1.03995448
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.03849277
35	Serotonergic synapse_Homo sapiens_hsa04726	1.02753634
36	Bile secretion_Homo sapiens_hsa04976	1.00728646
37	Huntingtons disease_Homo sapiens_hsa05016	0.99056015
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.97547279
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97439872
40	Circadian entrainment_Homo sapiens_hsa04713	0.97417711
41	Allograft rejection_Homo sapiens_hsa05330	0.97340436
42	Fatty acid metabolism_Homo sapiens_hsa01212	0.96597408
43	PPAR signaling pathway_Homo sapiens_hsa03320	0.94994385
44	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.94133004
45	Arginine biosynthesis_Homo sapiens_hsa00220	0.93373349
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.92632616
47	Graft-versus-host disease_Homo sapiens_hsa05332	0.90918753
48	Basal transcription factors_Homo sapiens_hsa03022	0.90730074
49	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.90728949
50	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.88598069
51	Morphine addiction_Homo sapiens_hsa05032	0.87892395
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87603243
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87027348
54	Salivary secretion_Homo sapiens_hsa04970	0.86675439
55	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.84010518
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83870176
57	GABAergic synapse_Homo sapiens_hsa04727	0.80859613
58	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.80607610
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.77875335
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.76945095
61	cAMP signaling pathway_Homo sapiens_hsa04024	0.76113262
62	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.73838164
63	mRNA surveillance pathway_Homo sapiens_hsa03015	0.73832924
64	Histidine metabolism_Homo sapiens_hsa00340	0.69628296
65	Insulin secretion_Homo sapiens_hsa04911	0.67413906
66	Viral myocarditis_Homo sapiens_hsa05416	0.66224039
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66099325
68	Antigen processing and presentation_Homo sapiens_hsa04612	0.65526752
69	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.64644385
70	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.63843868
71	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.63627018
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63488225
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.63432528
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.62618282
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61044839
76	Tight junction_Homo sapiens_hsa04530	0.58963985
77	Amphetamine addiction_Homo sapiens_hsa05031	0.56455662
78	Gastric acid secretion_Homo sapiens_hsa04971	0.56380544
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56232147
80	Renin secretion_Homo sapiens_hsa04924	0.54941495
81	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.54491244
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.51031365
83	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.50751615
84	Linoleic acid metabolism_Homo sapiens_hsa00591	0.49419891
85	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.44832232
86	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.43868973
87	Lysine degradation_Homo sapiens_hsa00310	0.43787870
88	Cholinergic synapse_Homo sapiens_hsa04725	0.43747289
89	MAPK signaling pathway_Homo sapiens_hsa04010	0.38936302
90	Long-term potentiation_Homo sapiens_hsa04720	0.38641636
91	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.38371290
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.37406887
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.37171713
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36882985
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36575141
96	Metabolic pathways_Homo sapiens_hsa01100	0.36228024
97	Renin-angiotensin system_Homo sapiens_hsa04614	0.34852613
98	Influenza A_Homo sapiens_hsa05164	0.34353984
99	Notch signaling pathway_Homo sapiens_hsa04330	0.33560447
100	Endocytosis_Homo sapiens_hsa04144	0.32985241

GOLGA6A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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