ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	9.87783324
2	sperm capacitation (GO:0048240)	9.52870188
3	chromosome condensation (GO:0030261)	9.13255127
4	DNA packaging (GO:0006323)	8.87508552
5	plasma membrane fusion (GO:0045026)	8.77306866
6	single strand break repair (GO:0000012)	8.45580846
7	spermatid nucleus differentiation (GO:0007289)	7.93098038
8	spermatid development (GO:0007286)	7.68151175
9	microtubule depolymerization (GO:0007019)	7.63928918
10	sperm-egg recognition (GO:0035036)	7.25387876
11	protein targeting to Golgi (GO:0000042)	6.94074182
12	multicellular organism reproduction (GO:0032504)	6.87054748
13	establishment of protein localization to Golgi (GO:0072600)	6.68918048
14	sexual reproduction (GO:0019953)	6.68374509
15	microtubule polymerization or depolymerization (GO:0031109)	6.67801831
16	reproduction (GO:0000003)	6.57968494
17	calcium ion-dependent exocytosis (GO:0017156)	6.53737506
18	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.48425511
19	binding of sperm to zona pellucida (GO:0007339)	6.46377220
20	protein polyglutamylation (GO:0018095)	6.42920432
21	centriole replication (GO:0007099)	6.40937004
22	rRNA methylation (GO:0031167)	6.31061714
23	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.18737325
24	axonemal dynein complex assembly (GO:0070286)	6.12929695
25	regulation of Rab GTPase activity (GO:0032313)	6.10059101
26	positive regulation of Rab GTPase activity (GO:0032851)	6.10059101
27	cell-cell recognition (GO:0009988)	5.98125323
28	spermatogenesis (GO:0007283)	5.95101635
29	male gamete generation (GO:0048232)	5.93097023
30	phosphatidylethanolamine metabolic process (GO:0046337)	5.70616006
31	negative regulation of inclusion body assembly (GO:0090084)	5.66225054
32	gamete generation (GO:0007276)	5.41999635
33	centriole assembly (GO:0098534)	5.40282093
34	regulation of transcription involved in cell fate commitment (GO:0060850)	5.35798689
35	microtubule severing (GO:0051013)	5.35374180
36	rRNA modification (GO:0000154)	5.26300363
37	regulation of cilium movement (GO:0003352)	5.21292349
38	regulation of centriole replication (GO:0046599)	5.10237273
39	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.98041281
40	protein localization to Golgi apparatus (GO:0034067)	4.94401286
41	cilium or flagellum-dependent cell motility (GO:0001539)	4.85622040
42	cellular ketone body metabolic process (GO:0046950)	4.84579932
43	chromatin silencing (GO:0006342)	4.83471891
44	cell wall macromolecule metabolic process (GO:0044036)	4.77907257
45	single fertilization (GO:0007338)	4.71302391
46	motile cilium assembly (GO:0044458)	4.62755863
47	cell wall macromolecule catabolic process (GO:0016998)	4.55765066
48	RNA destabilization (GO:0050779)	4.43740753
49	seminiferous tubule development (GO:0072520)	4.43104195
50	germ cell development (GO:0007281)	4.41314142
51	multicellular organismal reproductive process (GO:0048609)	4.33559765
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.32273048
53	ketone body metabolic process (GO:1902224)	4.26409300
54	regulation of inclusion body assembly (GO:0090083)	4.08371281
55	nucleus organization (GO:0006997)	4.04490481
56	musculoskeletal movement (GO:0050881)	4.01491542
57	multicellular organismal movement (GO:0050879)	4.01491542
58	fertilization (GO:0009566)	4.00282076
59	epithelial cilium movement (GO:0003351)	3.91137555
60	Golgi to endosome transport (GO:0006895)	3.84061762
61	coenzyme catabolic process (GO:0009109)	3.78922138
62	cerebral cortex neuron differentiation (GO:0021895)	3.75666758
63	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.67598217
64	organic cation transport (GO:0015695)	3.63805675
65	negative regulation of Rho protein signal transduction (GO:0035024)	3.51972168
66	glycerol ether metabolic process (GO:0006662)	3.51948297
67	regulation of microtubule-based movement (GO:0060632)	3.46395452
68	cilium movement (GO:0003341)	3.45919410
69	response to acidic pH (GO:0010447)	3.45356793
70	peptidyl-threonine dephosphorylation (GO:0035970)	3.43698782
71	microtubule nucleation (GO:0007020)	3.40632598
72	negative regulation of gene expression, epigenetic (GO:0045814)	3.30179785
73	regulation of interleukin-13 production (GO:0032656)	3.29186604
74	regulation of T-helper 2 cell differentiation (GO:0045628)	3.28606432
75	histone H3-K9 demethylation (GO:0033169)	3.26733857
76	ether metabolic process (GO:0018904)	3.24626591
77	nucleosome disassembly (GO:0006337)	3.22494643
78	protein-DNA complex disassembly (GO:0032986)	3.22494643
79	cellular response to pH (GO:0071467)	3.16766673
80	polyamine biosynthetic process (GO:0006596)	3.10326276
81	homeostasis of number of cells within a tissue (GO:0048873)	3.07630745
82	multicellular organismal development (GO:0007275)	2.96238109
83	negative regulation of histone methylation (GO:0031061)	2.95886510
84	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.90077254
85	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.90077254
86	DNA conformation change (GO:0071103)	2.88661975
87	membrane protein intracellular domain proteolysis (GO:0031293)	2.87747158
88	protein depolymerization (GO:0051261)	2.86765347
89	cell recognition (GO:0008037)	2.86692916
90	cranial nerve morphogenesis (GO:0021602)	2.85452338
91	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.83691788
92	regulation of ARF GTPase activity (GO:0032312)	2.83231309
93	NAD biosynthetic process (GO:0009435)	2.81703057
94	cell differentiation involved in metanephros development (GO:0072202)	2.79870156
95	male meiosis I (GO:0007141)	2.78882634
96	receptor recycling (GO:0001881)	2.78873435
97	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.77183864
98	acrosome reaction (GO:0007340)	11.7089316
99	fusion of sperm to egg plasma membrane (GO:0007342)	11.5472514
100	sperm motility (GO:0030317)	11.5223275

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.91354624
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.55513010
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.13143946
4	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.36918259
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36918259
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.23792507
7	CBP_20019798_ChIP-Seq_JUKART_Human	2.23702826
8	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.23702826
9	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.18018566
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16333015
11	DROSHA_22980978_ChIP-Seq_HELA_Human	2.10087984
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04282068
13	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.93568029
14	* ERA_21632823_ChIP-Seq_H3396_Human	1.92198100
15	* ELF1_20517297_ChIP-Seq_JURKAT_Human	1.91933059
16	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.91794471
17	RAC3_21632823_ChIP-Seq_H3396_Human	1.87493152
18	NANOG_20526341_ChIP-Seq_ESCs_Human	1.86543988
19	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.85360140
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84473071
21	* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.80677833
22	CTCF_27219007_Chip-Seq_Bcells_Human	1.78348691
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77074608
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.70790813
25	* BCL6_27268052_Chip-Seq_Bcells_Human	1.66885713
26	FUS_26573619_Chip-Seq_HEK293_Human	1.66861019
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64871404
28	* SMC4_20622854_ChIP-Seq_HELA_Human	1.61836113
29	TAF2_19829295_ChIP-Seq_ESCs_Human	1.60760177
30	BCOR_27268052_Chip-Seq_Bcells_Human	1.60340438
31	PHF8_20622854_ChIP-Seq_HELA_Human	1.59932506
32	* E2F1_20622854_ChIP-Seq_HELA_Human	1.58623655
33	CTCF_20526341_ChIP-Seq_ESCs_Human	1.56488999
34	OCT4_20526341_ChIP-Seq_ESCs_Human	1.53879501
35	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.52176568
36	* P68_20966046_ChIP-Seq_HELA_Human	1.51983790
37	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.50970494
38	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.50215819
39	* MYC_19829295_ChIP-Seq_ESCs_Human	1.49564340
40	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.48633588
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.48398965
42	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.48259153
43	TP63_22573176_ChIP-Seq_HFKS_Human	1.46269040
44	AR_21572438_ChIP-Seq_LNCaP_Human	1.45170555
45	P300_27268052_Chip-Seq_Bcells_Human	1.44281673
46	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.43683234
47	AR_25329375_ChIP-Seq_VCAP_Human	1.40665625
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37512781
49	LXR_22292898_ChIP-Seq_THP-1_Human	1.37352700
50	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.36442067
51	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.35860648
52	ERG_20517297_ChIP-Seq_VCAP_Human	1.35644275
53	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.35547143
54	ZNF274_21170338_ChIP-Seq_K562_Hela	1.34272428
55	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.32337366
56	RBPJ_21746931_ChIP-Seq_IB4_Human	1.30771783
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30563265
58	CEBPB_22108803_ChIP-Seq_LS180_Human	1.30244233
59	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.29419053
60	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.28636733
61	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.28523284
62	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.27636322
63	P53_21459846_ChIP-Seq_SAOS-2_Human	1.27616873
64	ETV1_20927104_ChIP-Seq_GIST48_Human	1.27404980
65	TP53_18474530_ChIP-ChIP_U2OS_Human	1.27391981
66	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26564110
67	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.26092622
68	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.25896034
69	TAF15_26573619_Chip-Seq_HEK293_Human	1.25556545
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24387725
71	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.23384085
72	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.22208263
73	NFYB_21822215_ChIP-Seq_K562_Human	1.18839167
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17269356
75	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16339297
76	P300_19829295_ChIP-Seq_ESCs_Human	1.15440009
77	TBL1_22424771_ChIP-Seq_293T_Human	1.15299495
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14593672
79	SA1_27219007_Chip-Seq_Bcells_Human	1.14352855
80	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.13043751
81	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.12091178
82	PHF8_20622853_ChIP-Seq_HELA_Human	1.10491084
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08360238
84	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.08014611
85	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.07423588
86	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.07160261
87	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.06333958
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.05647259
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05409155
90	* SMRT_27268052_Chip-Seq_Bcells_Human	1.04893102
91	NFYA_21822215_ChIP-Seq_K562_Human	1.03900999
92	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.02161358
93	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.02024051
94	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01734245
95	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01734245
96	KLF5_25053715_ChIP-Seq_YYC3_Human	1.00956819
97	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00949078
98	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98892758
99	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.97482998
100	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.97218764

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.55788685
2	MP0005377_hearing/vestibular/ear_phenot	5.55788685
3	MP0005670_abnormal_white_adipose	4.60341846
4	MP0003698_abnormal_male_reproductive	4.31136674
5	MP0001348_abnormal_lacrimal_gland	4.29058578
6	MP0001929_abnormal_gametogenesis	3.70429137
7	MP0000678_abnormal_parathyroid_gland	2.66210581
8	MP0005379_endocrine/exocrine_gland_phen	2.41408704
9	MP0002161_abnormal_fertility/fecundity	2.39359797
10	MP0002822_catalepsy	2.18810262
11	MP0002132_abnormal_respiratory_system	2.18670027
12	MP0003718_maternal_effect	2.17852534
13	MP0005410_abnormal_fertilization	11.9689346
14	MP0003646_muscle_fatigue	1.70655969
15	MP0002210_abnormal_sex_determination	1.67744928
16	MP0002249_abnormal_larynx_morphology	1.62038633
17	MP0001485_abnormal_pinna_reflex	1.59394171
18	MP0002234_abnormal_pharynx_morphology	1.56256410
19	MP0009053_abnormal_anal_canal	1.53474558
20	MP0005451_abnormal_body_composition	1.52724231
21	MP0001486_abnormal_startle_reflex	1.52343893
22	MP0005423_abnormal_somatic_nervous	1.47347773
23	MP0003011_delayed_dark_adaptation	1.47136395
24	MP0002282_abnormal_trachea_morphology	1.46431923
25	MP0001145_abnormal_male_reproductive	1.31977897
26	MP0002735_abnormal_chemical_nociception	1.29590459
27	MP0000653_abnormal_sex_gland	1.28066523
28	MP0004859_abnormal_synaptic_plasticity	1.24933001
29	MP0004742_abnormal_vestibular_system	1.22979845
30	MP0000534_abnormal_ureter_morphology	1.22547027
31	MP0001968_abnormal_touch/_nociception	1.19830960
32	MP0002138_abnormal_hepatobiliary_system	1.18407343
33	MP0005310_abnormal_salivary_gland	1.18404371
34	MP0003879_abnormal_hair_cell	1.18226637
35	MP0001765_abnormal_ion_homeostasis	1.13594368
36	MP0004510_myositis	1.12893877
37	MP0002127_abnormal_cardiovascular_syste	1.10409470
38	MP0001963_abnormal_hearing_physiology	1.09484175
39	MP0005248_abnormal_Harderian_gland	1.06898890
40	MP0000026_abnormal_inner_ear	1.01601896
41	MP0005395_other_phenotype	1.01562878
42	MP0000955_abnormal_spinal_cord	0.86149378
43	MP0000681_abnormal_thyroid_gland	0.85044332
44	MP0005666_abnormal_adipose_tissue	0.84055483
45	MP0002229_neurodegeneration	0.81268377
46	MP0001905_abnormal_dopamine_level	0.81025222
47	MP0008569_lethality_at_weaning	0.79659638
48	MP0000049_abnormal_middle_ear	0.77659056
49	MP0002733_abnormal_thermal_nociception	0.77199458
50	MP0005551_abnormal_eye_electrophysiolog	0.77054612
51	MP0008877_abnormal_DNA_methylation	0.76806355
52	MP0000516_abnormal_urinary_system	0.73317099
53	MP0005367_renal/urinary_system_phenotyp	0.73317099
54	MP0002067_abnormal_sensory_capabilities	0.72936217
55	MP0005167_abnormal_blood-brain_barrier	0.71800662
56	MP0009115_abnormal_fat_cell	0.71368835
57	MP0005375_adipose_tissue_phenotype	0.69225108
58	MP0001666_abnormal_nutrient_absorption	0.69045718
59	MP0004085_abnormal_heartbeat	0.68372667
60	MP0002557_abnormal_social/conspecific_i	0.67414991
61	MP0005535_abnormal_body_temperature	0.61542737
62	MP0002572_abnormal_emotion/affect_behav	0.60650999
63	MP0005253_abnormal_eye_physiology	0.60036282
64	MP0005636_abnormal_mineral_homeostasis	0.57387705
65	MP0001440_abnormal_grooming_behavior	0.57135189
66	MP0009745_abnormal_behavioral_response	0.57004323
67	MP0002653_abnormal_ependyma_morphology	0.56587993
68	MP0004233_abnormal_muscle_weight	0.56319510
69	MP0000003_abnormal_adipose_tissue	0.55588495
70	MP0004484_altered_response_of	0.53908106
71	MP0001970_abnormal_pain_threshold	0.52327860
72	MP0001879_abnormal_lymphatic_vessel	0.52306149
73	MP0003119_abnormal_digestive_system	0.51427649
74	MP0002734_abnormal_mechanical_nocicepti	0.50857067
75	MP0009697_abnormal_copulation	0.50763897
76	MP0005623_abnormal_meninges_morphology	0.45814981
77	MP0002272_abnormal_nervous_system	0.45251283
78	MP0005083_abnormal_biliary_tract	0.44261284
79	MP0000470_abnormal_stomach_morphology	0.43206591
80	MP0003077_abnormal_cell_cycle	0.43118089
81	MP0006292_abnormal_olfactory_placode	0.41985188
82	MP0002928_abnormal_bile_duct	0.41158417
83	MP0003137_abnormal_impulse_conducting	0.39287130
84	MP0000566_synostosis	0.39211091
85	MP0003699_abnormal_female_reproductive	0.38940137
86	MP0001545_abnormal_hematopoietic_system	0.38897128
87	MP0005397_hematopoietic_system_phenotyp	0.38897128
88	MP0001501_abnormal_sleep_pattern	0.37420805
89	MP0000249_abnormal_blood_vessel	0.37163571
90	MP0003936_abnormal_reproductive_system	0.37036822
91	MP0003635_abnormal_synaptic_transmissio	0.36733464
92	MP0004036_abnormal_muscle_relaxation	0.36694029
93	MP0009764_decreased_sensitivity_to	0.35414915
94	MP0008995_early_reproductive_senescence	0.34494220
95	MP0001270_distended_abdomen	0.33242940
96	MP0008961_abnormal_basal_metabolism	0.32358011
97	MP0003880_abnormal_central_pattern	0.32207461
98	MP0003091_abnormal_cell_migration	0.31640186
99	MP0005391_vision/eye_phenotype	0.31525646
100	MP0003631_nervous_system_phenotype	0.31314535

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.21115917
2	Asymmetric septal hypertrophy (HP:0001670)	6.12196900
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.94123419
4	Absent/shortened dynein arms (HP:0200106)	5.94123419
5	Attenuation of retinal blood vessels (HP:0007843)	5.18796550
6	Bony spicule pigmentary retinopathy (HP:0007737)	5.17103298
7	Bell-shaped thorax (HP:0001591)	4.82007690
8	Abnormal ciliary motility (HP:0012262)	4.59478670
9	Male infertility (HP:0003251)	4.54110169
10	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.51356535
11	Resting tremor (HP:0002322)	4.48425075
12	Abnormal respiratory motile cilium physiology (HP:0012261)	4.45746362
13	Tubulointerstitial nephritis (HP:0001970)	4.35770805
14	Abnormal respiratory epithelium morphology (HP:0012253)	4.34583668
15	Abnormal respiratory motile cilium morphology (HP:0005938)	4.34583668
16	Hypoplastic ischia (HP:0003175)	4.29094314
17	Hyperkalemia (HP:0002153)	4.27501426
18	Infertility (HP:0000789)	4.17993797
19	Facial shape deformation (HP:0011334)	4.15186079
20	Potter facies (HP:0002009)	4.15186079
21	Chronic hepatic failure (HP:0100626)	4.06074366
22	Enlarged epiphyses (HP:0010580)	4.01150952
23	Abnormal rod and cone electroretinograms (HP:0008323)	3.90869130
24	Nasal polyposis (HP:0100582)	3.85908483
25	Abnormality of the ischium (HP:0003174)	3.81183743
26	Impulsivity (HP:0100710)	3.80327376
27	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.77601559
28	Abnormality of macular pigmentation (HP:0008002)	3.77445118
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.66112436
30	Cone-rod dystrophy (HP:0000548)	3.37408392
31	Abnormal spermatogenesis (HP:0008669)	3.36452999
32	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.26561237
33	Hypoplasia of the thymus (HP:0000778)	3.15285903
34	Azoospermia (HP:0000027)	3.13178092
35	Abnormality of the nasal mucosa (HP:0000433)	3.11325786
36	Postural instability (HP:0002172)	3.04287587
37	Nephronophthisis (HP:0000090)	2.94255908
38	Abnormal urine output (HP:0012590)	2.87621191
39	Abnormality of the costochondral junction (HP:0000919)	2.76312760
40	Epiphyseal dysplasia (HP:0002656)	2.71626872
41	Progressive cerebellar ataxia (HP:0002073)	2.63223470
42	Double outlet right ventricle (HP:0001719)	2.60659270
43	Congenital malformation of the right heart (HP:0011723)	2.60659270
44	Amelogenesis imperfecta (HP:0000705)	2.59621625
45	Unilateral renal agenesis (HP:0000122)	2.57458383
46	Rhinitis (HP:0012384)	2.57329056
47	Generalized aminoaciduria (HP:0002909)	2.56036807
48	Abnormality of the aortic arch (HP:0012303)	2.53256600
49	Abnormality of potassium homeostasis (HP:0011042)	2.51853300
50	Progressive sensorineural hearing impairment (HP:0000408)	2.51491897
51	Stage 5 chronic kidney disease (HP:0003774)	2.50693191
52	Renal dysplasia (HP:0000110)	2.48717729
53	Abnormality of dental color (HP:0011073)	2.48016060
54	Abnormality of renal excretion (HP:0011036)	2.47771043
55	Abnormality of the renal medulla (HP:0100957)	2.46614771
56	Hypoalphalipoproteinemia (HP:0003233)	2.46537294
57	Portal hypertension (HP:0001409)	2.45099903
58	Truncal obesity (HP:0001956)	2.35543170
59	Hypophosphatemic rickets (HP:0004912)	2.35333517
60	Abnormal drinking behavior (HP:0030082)	2.35023109
61	Polydipsia (HP:0001959)	2.35023109
62	Tubulointerstitial abnormality (HP:0001969)	2.30740325
63	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.28106609
64	Absent epiphyses (HP:0010577)	2.28106609
65	Widely patent fontanelles and sutures (HP:0004492)	2.26349675
66	Polyuria (HP:0000103)	2.25604020
67	Abnormality of the hepatic vasculature (HP:0006707)	2.22708847
68	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.22647512
69	Abnormality of the parathyroid morphology (HP:0011766)	2.22365899
70	Intellectual disability, moderate (HP:0002342)	2.18865562
71	Spastic paraparesis (HP:0002313)	2.15380379
72	Ventricular tachycardia (HP:0004756)	2.15219860
73	Abnormality of the pubic bones (HP:0003172)	2.13575864
74	Hyponatremia (HP:0002902)	2.08906285
75	Mixed hearing impairment (HP:0000410)	2.05387335
76	Renovascular hypertension (HP:0100817)	2.05262806
77	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.02980380
78	Flattened epiphyses (HP:0003071)	1.96839226
79	Bronchiectasis (HP:0002110)	1.96416741
80	Insulin-resistant diabetes mellitus (HP:0000831)	1.93821141
81	Osteomalacia (HP:0002749)	1.92970776
82	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.90825036
83	Abnormality of femoral epiphyses (HP:0006499)	1.90825036
84	Decreased central vision (HP:0007663)	1.88568920
85	Short ribs (HP:0000773)	1.88239979
86	Menstrual irregularities (HP:0000858)	1.87539028
87	Chronic bronchitis (HP:0004469)	1.86988521
88	Occipital encephalocele (HP:0002085)	1.84865177
89	Abnormal ventriculo-arterial connection (HP:0011563)	1.82540732
90	Transposition of the great arteries (HP:0001669)	1.82540732
91	Abnormal connection of the cardiac segments (HP:0011545)	1.82540732
92	Tubular atrophy (HP:0000092)	1.82292030
93	Protuberant abdomen (HP:0001538)	1.80933768
94	Sensory axonal neuropathy (HP:0003390)	1.79663430
95	Abnormality of the femoral head (HP:0003368)	1.79256295
96	Vertebral clefting (HP:0008428)	1.76969644
97	Recurrent corneal erosions (HP:0000495)	1.75815414
98	Recurrent pneumonia (HP:0006532)	1.73867955
99	Anterior segment dysgenesis (HP:0007700)	1.69053585
100	Bradycardia (HP:0001662)	1.68497753

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	9.01335625
2	TESK1	6.15206360
3	DDR2	5.37416141
4	INSRR	3.44700747
5	PLK2	3.37969730
6	BRD4	3.03512084
7	STK38	2.89154421
8	PNCK	2.73582481
9	MAP4K2	2.48386405
10	MAPK15	2.34248152
11	CAMK1G	2.29847117
12	MST1R	2.17352205
13	STK38L	2.06013660
14	PRKD3	1.91699691
15	PIK3CG	1.69897656
16	PDPK1	1.63689732
17	WNK1	1.62734459
18	PDK1	1.51840927
19	CDK7	1.48681277
20	CDK12	1.43574362
21	PTK2B	1.24687242
22	DYRK1B	1.18353214
23	NEK6	1.13813881
24	MAP3K9	0.99573172
25	CAMK1D	0.96936634
26	KSR2	0.92029334
27	LATS2	0.86924204
28	SIK2	0.84793430
29	UHMK1	0.82627781
30	RPS6KA2	0.80633429
31	AKT3	0.79251827
32	PRKG2	0.78587196
33	PRKG1	0.73911617
34	BRAF	0.72582075
35	TYRO3	0.65699869
36	MAP3K11	0.64864019
37	PRKAA2	0.64519173
38	WNK4	0.64436506
39	LATS1	0.63992447
40	RPS6KA1	0.62874358
41	TESK2	0.59283235
42	MAP2K2	0.56473053
43	MAP3K2	0.52860857
44	CAMK1	0.49099957
45	ROCK1	0.48110049
46	MAP3K8	0.47441011
47	RPS6KL1	0.47298676
48	RPS6KC1	0.47298676
49	JAK3	0.47262778
50	MUSK	0.47003471
51	CDK2	0.46241471
52	GSK3B	0.44364144
53	CDK19	0.44322455
54	RPS6KA6	0.43254436
55	STK39	0.43063561
56	MAPK1	0.41124031
57	MET	0.39861469
58	CDK1	0.39630267
59	CDK3	0.39281116
60	MTOR	0.38468015
61	ARAF	0.35482613
62	SGK494	0.34606837
63	SGK223	0.34606837
64	MARK1	0.34376157
65	PRKCG	0.33803702
66	MAPK8	0.31897323
67	OXSR1	0.31752978
68	MAPK11	0.30512931
69	PRKCZ	0.29569998
70	CHEK1	0.29324015
71	RIPK4	0.27913334
72	CAMK4	0.27556750
73	BMPR1B	0.27137385
74	PRKCB	0.26988015
75	NTRK3	0.25581984
76	SGK1	0.25459002
77	MAPK14	0.24559434
78	MAP3K1	0.24126216
79	CDK4	0.23530134
80	TNIK	0.22848803
81	MAP3K4	0.22572798
82	ADRBK2	0.22302231
83	BRSK1	0.21239200
84	TIE1	0.20929030
85	FER	0.20114756
86	MAPK10	0.19552437
87	NEK2	0.19113854
88	MARK2	0.17886570
89	AKT1	0.17743199
90	PKN1	0.17705228
91	FRK	0.17158175
92	RIPK1	0.14520625
93	DYRK3	0.11773117
94	PRKCE	0.11556414
95	PRKACB	0.10691301
96	PRKACA	0.09393396
97	PRKAA1	0.08782802
98	IKBKB	0.08591372
99	SGK2	0.07977530
100	CDK11A	0.07453281

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.02885370
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.53452354
3	Olfactory transduction_Homo sapiens_hsa04740	4.10702377
4	Butanoate metabolism_Homo sapiens_hsa00650	2.41296628
5	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.37163702
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.08835004
7	Type I diabetes mellitus_Homo sapiens_hsa04940	1.89296835
8	Allograft rejection_Homo sapiens_hsa05330	1.88610966
9	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.87950351
10	Taste transduction_Homo sapiens_hsa04742	1.84257360
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.84116386
12	Graft-versus-host disease_Homo sapiens_hsa05332	1.75505877
13	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.55154742
14	Phenylalanine metabolism_Homo sapiens_hsa00360	1.54458241
15	Type II diabetes mellitus_Homo sapiens_hsa04930	1.52744998
16	Fatty acid degradation_Homo sapiens_hsa00071	1.49423870
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.47672683
18	RNA transport_Homo sapiens_hsa03013	1.39748127
19	Protein digestion and absorption_Homo sapiens_hsa04974	1.34724518
20	Viral myocarditis_Homo sapiens_hsa05416	1.33031704
21	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.31182346
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.28901010
23	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.26086562
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21108640
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.20455706
26	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.17080112
27	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.16594029
28	Phototransduction_Homo sapiens_hsa04744	1.15830396
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.14026512
30	Salivary secretion_Homo sapiens_hsa04970	1.11865306
31	ABC transporters_Homo sapiens_hsa02010	1.09276789
32	Endocytosis_Homo sapiens_hsa04144	1.09080057
33	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.03311748
34	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.01624415
35	Arginine biosynthesis_Homo sapiens_hsa00220	1.00649867
36	Oocyte meiosis_Homo sapiens_hsa04114	1.00454561
37	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.95194255
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.92626421
39	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.92558124
40	Renin-angiotensin system_Homo sapiens_hsa04614	0.89014336
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87839073
42	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.84275084
43	Morphine addiction_Homo sapiens_hsa05032	0.84238636
44	cAMP signaling pathway_Homo sapiens_hsa04024	0.83416355
45	Fat digestion and absorption_Homo sapiens_hsa04975	0.83143355
46	Cardiac muscle contraction_Homo sapiens_hsa04260	0.82768603
47	Circadian entrainment_Homo sapiens_hsa04713	0.82439001
48	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.81136340
49	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76645076
50	PPAR signaling pathway_Homo sapiens_hsa03320	0.74669334
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74403080
52	Retinol metabolism_Homo sapiens_hsa00830	0.73176289
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.73055108
54	Influenza A_Homo sapiens_hsa05164	0.71499226
55	Bile secretion_Homo sapiens_hsa04976	0.71226073
56	Nicotine addiction_Homo sapiens_hsa05033	0.71127727
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.70241571
58	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.68854756
59	Estrogen signaling pathway_Homo sapiens_hsa04915	0.65961844
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65734268
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.65362779
62	Gastric acid secretion_Homo sapiens_hsa04971	0.64807504
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.64621052
64	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58702811
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57188565
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.56958672
67	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.55773855
68	Renin secretion_Homo sapiens_hsa04924	0.54722261
69	Tight junction_Homo sapiens_hsa04530	0.51451706
70	Acute myeloid leukemia_Homo sapiens_hsa05221	0.49091740
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48209746
72	Purine metabolism_Homo sapiens_hsa00230	0.47815338
73	Basal transcription factors_Homo sapiens_hsa03022	0.47146906
74	VEGF signaling pathway_Homo sapiens_hsa04370	0.46604906
75	Insulin secretion_Homo sapiens_hsa04911	0.46338169
76	Cholinergic synapse_Homo sapiens_hsa04725	0.45647624
77	Serotonergic synapse_Homo sapiens_hsa04726	0.44781780
78	MAPK signaling pathway_Homo sapiens_hsa04010	0.44278686
79	ECM-receptor interaction_Homo sapiens_hsa04512	0.43351562
80	Pancreatic secretion_Homo sapiens_hsa04972	0.37603473
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.30835077
82	GABAergic synapse_Homo sapiens_hsa04727	0.30550120
83	Nitrogen metabolism_Homo sapiens_hsa00910	0.29050525
84	Prolactin signaling pathway_Homo sapiens_hsa04917	0.29016912
85	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.28501391
86	Fanconi anemia pathway_Homo sapiens_hsa03460	0.28388219
87	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.28110767
88	Linoleic acid metabolism_Homo sapiens_hsa00591	0.26841100
89	mRNA surveillance pathway_Homo sapiens_hsa03015	0.25471175
90	Viral carcinogenesis_Homo sapiens_hsa05203	0.25255621
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.23587866
92	Long-term potentiation_Homo sapiens_hsa04720	0.23009371
93	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.22935534
94	Huntingtons disease_Homo sapiens_hsa05016	0.20559133
95	Herpes simplex infection_Homo sapiens_hsa05168	0.19167690
96	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.18371173
97	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.15448949
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.13772432
99	Adherens junction_Homo sapiens_hsa04520	0.13630223
100	Choline metabolism in cancer_Homo sapiens_hsa05231	0.13114422

GOLGA6B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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