GOLGA6D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.77096281
2response to pheromone (GO:0019236)9.70100188
3chromosome condensation (GO:0030261)8.96324071
4plasma membrane fusion (GO:0045026)8.88229320
5DNA packaging (GO:0006323)8.74421280
6single strand break repair (GO:0000012)8.13865381
7microtubule depolymerization (GO:0007019)7.95045961
8spermatid development (GO:0007286)7.93679547
9spermatid nucleus differentiation (GO:0007289)7.74781664
10sperm-egg recognition (GO:0035036)7.31424148
11multicellular organism reproduction (GO:0032504)7.11218086
12microtubule polymerization or depolymerization (GO:0031109)6.78271401
13reproduction (GO:0000003)6.70793841
14calcium ion-dependent exocytosis (GO:0017156)6.62502913
15sexual reproduction (GO:0019953)6.52731168
16phosphatidylethanolamine biosynthetic process (GO:0006646)6.52684824
17protein polyglutamylation (GO:0018095)6.52664529
18protein targeting to Golgi (GO:0000042)6.50343131
19binding of sperm to zona pellucida (GO:0007339)6.42270136
20rRNA methylation (GO:0031167)6.36122802
21establishment of protein localization to Golgi (GO:0072600)6.28511380
22axonemal dynein complex assembly (GO:0070286)6.16114037
23centriole replication (GO:0007099)6.15733649
24negative regulation of inclusion body assembly (GO:0090084)6.09674299
25retrograde transport, vesicle recycling within Golgi (GO:0000301)6.05403875
26cell-cell recognition (GO:0009988)6.03390433
27phosphatidylethanolamine metabolic process (GO:0046337)6.01752739
28spermatogenesis (GO:0007283)5.98185118
29male gamete generation (GO:0048232)5.96110187
30regulation of Rab GTPase activity (GO:0032313)5.94890078
31positive regulation of Rab GTPase activity (GO:0032851)5.94890078
32microtubule severing (GO:0051013)5.79381098
33regulation of transcription involved in cell fate commitment (GO:0060850)5.55418456
34gamete generation (GO:0007276)5.45063402
35rRNA modification (GO:0000154)5.33763745
36regulation of cilium movement (GO:0003352)5.31000885
37centriole assembly (GO:0098534)5.25832598
38cellular ketone body metabolic process (GO:0046950)5.03890756
39regulation of centriole replication (GO:0046599)4.87208212
40cilium or flagellum-dependent cell motility (GO:0001539)4.86899025
41cell wall macromolecule metabolic process (GO:0044036)4.86428926
42single fertilization (GO:0007338)4.79389477
43cell wall macromolecule catabolic process (GO:0016998)4.71363746
44protein localization to Golgi apparatus (GO:0034067)4.64992700
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.57375021
46chromatin silencing (GO:0006342)4.56038201
47germ cell development (GO:0007281)4.54272794
48RNA destabilization (GO:0050779)4.53218452
49motile cilium assembly (GO:0044458)4.51113250
50ketone body metabolic process (GO:1902224)4.43936331
51cellular process involved in reproduction in multicellular organism (GO:0022412)4.40189889
52regulation of inclusion body assembly (GO:0090083)4.39282752
53multicellular organismal reproductive process (GO:0048609)4.36289604
54seminiferous tubule development (GO:0072520)4.14027192
55fertilization (GO:0009566)4.02375014
56nucleus organization (GO:0006997)4.01511884
57multicellular organismal movement (GO:0050879)4.00692200
58musculoskeletal movement (GO:0050881)4.00692200
59epithelial cilium movement (GO:0003351)3.89281559
60organic cation transport (GO:0015695)3.85452386
61coenzyme catabolic process (GO:0009109)3.78581271
62Golgi to endosome transport (GO:0006895)3.77776932
63cerebral cortex neuron differentiation (GO:0021895)3.77315104
64peptidyl-threonine dephosphorylation (GO:0035970)3.71887529
65response to acidic pH (GO:0010447)3.69389263
66regulation of microtubule-based movement (GO:0060632)3.61384435
67cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.50339488
68negative regulation of Rho protein signal transduction (GO:0035024)3.45538097
69cilium movement (GO:0003341)3.43981555
70cellular response to pH (GO:0071467)3.41006682
71glycerol ether metabolic process (GO:0006662)3.35820625
72polyamine biosynthetic process (GO:0006596)3.28104100
73regulation of T-helper 2 cell differentiation (GO:0045628)3.26672066
74regulation of interleukin-13 production (GO:0032656)3.25732517
75microtubule nucleation (GO:0007020)3.25039199
76homeostasis of number of cells within a tissue (GO:0048873)3.15978797
77protein-DNA complex disassembly (GO:0032986)3.15404741
78nucleosome disassembly (GO:0006337)3.15404741
79negative regulation of gene expression, epigenetic (GO:0045814)3.11059824
80histone H3-K9 demethylation (GO:0033169)3.10981494
81ether metabolic process (GO:0018904)3.09178570
82membrane protein intracellular domain proteolysis (GO:0031293)3.06879838
83multicellular organismal development (GO:0007275)3.01932219
84protein depolymerization (GO:0051261)2.98358668
85negative regulation of histone methylation (GO:0031061)2.90012319
86cell recognition (GO:0008037)2.88551042
87regulation of somitogenesis (GO:0014807)2.87359353
88mesenchymal cell differentiation involved in kidney development (GO:0072161)2.86204625
89mesenchymal cell differentiation involved in renal system development (GO:2001012)2.86204625
90regulation of phosphoprotein phosphatase activity (GO:0043666)2.85945945
91cranial nerve morphogenesis (GO:0021602)2.83420586
92DNA conformation change (GO:0071103)2.83407222
93mitotic G1 DNA damage checkpoint (GO:0031571)2.82410660
94positive regulation of endothelial cell differentiation (GO:0045603)2.78281784
95positive regulation of guanylate cyclase activity (GO:0031284)2.78226825
96NAD biosynthetic process (GO:0009435)2.78203899
97regulation of guanylate cyclase activity (GO:0031282)2.77970513
98acrosome reaction (GO:0007340)11.8431299
99fusion of sperm to egg plasma membrane (GO:0007342)11.7056473
100sperm motility (GO:0030317)11.6626137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.88493453
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.55042041
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.99020979
4EZH2_22144423_ChIP-Seq_EOC_Human2.54465908
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.34099461
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34099461
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.20091751
8CBP_20019798_ChIP-Seq_JUKART_Human2.19629602
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.19629602
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18963129
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17718344
12ELF1_20517297_ChIP-Seq_JURKAT_Human2.13509397
13DROSHA_22980978_ChIP-Seq_HELA_Human2.04501613
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03861194
15EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.99028809
16ERA_21632823_ChIP-Seq_H3396_Human1.96802826
17WDR5_24793694_ChIP-Seq_LNCAP_Human1.90269485
18* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.83494793
19CTCF_27219007_Chip-Seq_Bcells_Human1.77921298
20EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.77894089
21* NANOG_20526341_ChIP-Seq_ESCs_Human1.75452201
22* RAC3_21632823_ChIP-Seq_H3396_Human1.74006389
23SMC4_20622854_ChIP-Seq_HELA_Human1.72408950
24FUS_26573619_Chip-Seq_HEK293_Human1.68849595
25* BCL6_27268052_Chip-Seq_Bcells_Human1.66504085
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62566405
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61524405
28PHF8_20622854_ChIP-Seq_HELA_Human1.61216689
29BCOR_27268052_Chip-Seq_Bcells_Human1.60844846
30ER_23166858_ChIP-Seq_MCF-7_Human1.60213028
31* E2F1_20622854_ChIP-Seq_HELA_Human1.59680491
32PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.58561505
33MYC_19829295_ChIP-Seq_ESCs_Human1.57856317
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.55270924
35OCT4_20526341_ChIP-Seq_ESCs_Human1.55116821
36* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54470416
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.51714122
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.51329696
39* P68_20966046_ChIP-Seq_HELA_Human1.49948245
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.48890460
41* TAF2_19829295_ChIP-Seq_ESCs_Human1.48232758
42TAF15_26573619_Chip-Seq_HEK293_Human1.46626705
43P300_27268052_Chip-Seq_Bcells_Human1.45605560
44SMAD4_21741376_ChIP-Seq_EPCs_Human1.45428856
45AR_21572438_ChIP-Seq_LNCaP_Human1.45269160
46TP63_22573176_ChIP-Seq_HFKS_Human1.44034445
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43956004
48AR_25329375_ChIP-Seq_VCAP_Human1.42139576
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.42081274
50* CTCF_20526341_ChIP-Seq_ESCs_Human1.41443779
51LXR_22292898_ChIP-Seq_THP-1_Human1.40658648
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38692700
53ERG_20517297_ChIP-Seq_VCAP_Human1.38433601
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33053244
55HNFA_21074721_ChIP-Seq_CACO-2_Human1.32282088
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31487900
57RBPJ_21746931_ChIP-Seq_IB4_Human1.30424413
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30165593
59CBX2_22325352_ChIP-Seq_293T-Rex_Human1.28721265
60* SMAD3_21741376_ChIP-Seq_ESCs_Human1.27129588
61TP53_18474530_ChIP-ChIP_U2OS_Human1.26990941
62ETV1_20927104_ChIP-Seq_GIST48_Human1.26977696
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26873806
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.26264102
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.25305164
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24360493
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24244884
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23221640
69ZNF274_21170338_ChIP-Seq_K562_Hela1.19384862
70* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18721217
71NFYB_21822215_ChIP-Seq_K562_Human1.18290818
72SMRT_27268052_Chip-Seq_Bcells_Human1.16294570
73RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15992191
74* GATA3_21878914_ChIP-Seq_MCF-7_Human1.15351972
75P300_19829295_ChIP-Seq_ESCs_Human1.15265049
76* CEBPB_22108803_ChIP-Seq_LS180_Human1.14511377
77* P53_21459846_ChIP-Seq_SAOS-2_Human1.14330508
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13994237
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13364787
80TBL1_22424771_ChIP-Seq_293T_Human1.12700846
81SA1_27219007_Chip-Seq_Bcells_Human1.12624589
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11645129
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.09248913
84SMAD4_21741376_ChIP-Seq_HESCs_Human1.08287593
85PHF8_20622853_ChIP-Seq_HELA_Human1.08217365
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07108626
87RUNX2_22187159_ChIP-Seq_PCA_Human1.06089656
88GATA6_21074721_ChIP-Seq_CACO-2_Human1.05920021
89NANOG_19829295_ChIP-Seq_ESCs_Human1.05866351
90SOX2_19829295_ChIP-Seq_ESCs_Human1.05866351
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05604275
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.04722259
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03643110
94KLF5_25053715_ChIP-Seq_YYC3_Human1.03152442
95NFYA_21822215_ChIP-Seq_K562_Human1.02372191
96OCT4_19829295_ChIP-Seq_ESCs_Human0.99468585
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.99037657
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97820483
99RUNX_20019798_ChIP-Seq_JUKART_Human0.97627663
100OCT1_27270436_Chip-Seq_PROSTATE_Human0.97444593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.30244063
2MP0003878_abnormal_ear_physiology5.30244063
3MP0005670_abnormal_white_adipose4.80047713
4MP0003698_abnormal_male_reproductive4.40982179
5MP0001929_abnormal_gametogenesis3.82255238
6MP0001348_abnormal_lacrimal_gland3.63982298
7MP0000678_abnormal_parathyroid_gland2.57441504
8MP0002161_abnormal_fertility/fecundity2.48129326
9MP0002822_catalepsy2.36952208
10MP0003718_maternal_effect2.24730396
11MP0002132_abnormal_respiratory_system2.02438798
12MP0005410_abnormal_fertilization12.2167104
13MP0003646_muscle_fatigue1.97305776
14MP0005379_endocrine/exocrine_gland_phen1.90975288
15MP0002210_abnormal_sex_determination1.74937845
16MP0002234_abnormal_pharynx_morphology1.72748155
17MP0003011_delayed_dark_adaptation1.64341500
18MP0001485_abnormal_pinna_reflex1.57378069
19MP0002249_abnormal_larynx_morphology1.56363471
20MP0005423_abnormal_somatic_nervous1.54881325
21MP0005451_abnormal_body_composition1.51451655
22MP0009053_abnormal_anal_canal1.45819130
23MP0001486_abnormal_startle_reflex1.41038540
24MP0002282_abnormal_trachea_morphology1.40532758
25MP0001145_abnormal_male_reproductive1.39353990
26MP0000653_abnormal_sex_gland1.34808932
27MP0002735_abnormal_chemical_nociception1.30982734
28MP0004859_abnormal_synaptic_plasticity1.28383960
29MP0000534_abnormal_ureter_morphology1.24439477
30MP0004510_myositis1.22099034
31MP0005310_abnormal_salivary_gland1.20749186
32MP0001968_abnormal_touch/_nociception1.18830347
33MP0001765_abnormal_ion_homeostasis1.16663554
34MP0002138_abnormal_hepatobiliary_system1.15173035
35MP0002127_abnormal_cardiovascular_syste1.13017832
36MP0004742_abnormal_vestibular_system1.10187028
37MP0001963_abnormal_hearing_physiology1.09136121
38MP0003879_abnormal_hair_cell1.05898386
39MP0005248_abnormal_Harderian_gland1.05564916
40MP0000026_abnormal_inner_ear1.01365393
41MP0005395_other_phenotype1.00074909
42MP0000955_abnormal_spinal_cord0.87797378
43MP0001905_abnormal_dopamine_level0.87231407
44MP0002229_neurodegeneration0.85725127
45MP0000681_abnormal_thyroid_gland0.84106804
46MP0008569_lethality_at_weaning0.83037326
47MP0005551_abnormal_eye_electrophysiolog0.80642482
48MP0005666_abnormal_adipose_tissue0.79334552
49MP0000049_abnormal_middle_ear0.77999396
50MP0002067_abnormal_sensory_capabilities0.77521406
51MP0002733_abnormal_thermal_nociception0.77025590
52MP0009115_abnormal_fat_cell0.74369750
53MP0008877_abnormal_DNA_methylation0.71918161
54MP0004085_abnormal_heartbeat0.70354547
55MP0005253_abnormal_eye_physiology0.69864770
56MP0001666_abnormal_nutrient_absorption0.68964000
57MP0000516_abnormal_urinary_system0.68260215
58MP0005367_renal/urinary_system_phenotyp0.68260215
59MP0002557_abnormal_social/conspecific_i0.68048881
60MP0005167_abnormal_blood-brain_barrier0.67103341
61MP0005375_adipose_tissue_phenotype0.64921488
62MP0009745_abnormal_behavioral_response0.60713263
63MP0001440_abnormal_grooming_behavior0.60689816
64MP0005636_abnormal_mineral_homeostasis0.60407884
65MP0002572_abnormal_emotion/affect_behav0.59766456
66MP0004484_altered_response_of0.59673906
67MP0001879_abnormal_lymphatic_vessel0.59462256
68MP0006292_abnormal_olfactory_placode0.55540310
69MP0003077_abnormal_cell_cycle0.53433612
70MP0005535_abnormal_body_temperature0.53131819
71MP0002734_abnormal_mechanical_nocicepti0.52486794
72MP0000003_abnormal_adipose_tissue0.52103392
73MP0003119_abnormal_digestive_system0.51782678
74MP0005083_abnormal_biliary_tract0.50810106
75MP0001970_abnormal_pain_threshold0.50373140
76MP0004233_abnormal_muscle_weight0.49106184
77MP0002272_abnormal_nervous_system0.48976991
78MP0009697_abnormal_copulation0.47364784
79MP0008995_early_reproductive_senescence0.44645828
80MP0003699_abnormal_female_reproductive0.43642828
81MP0004036_abnormal_muscle_relaxation0.42979525
82MP0009764_decreased_sensitivity_to0.41565699
83MP0003137_abnormal_impulse_conducting0.40869340
84MP0000470_abnormal_stomach_morphology0.40811377
85MP0000566_synostosis0.39663828
86MP0005623_abnormal_meninges_morphology0.39015358
87MP0005391_vision/eye_phenotype0.38413100
88MP0003936_abnormal_reproductive_system0.38176136
89MP0000249_abnormal_blood_vessel0.37568143
90MP0003635_abnormal_synaptic_transmissio0.36603450
91MP0000613_abnormal_salivary_gland0.34422185
92MP0001501_abnormal_sleep_pattern0.33860590
93MP0003091_abnormal_cell_migration0.33764219
94MP0003880_abnormal_central_pattern0.33107742
95MP0003631_nervous_system_phenotype0.31916529
96MP0001270_distended_abdomen0.31682325
97MP0008961_abnormal_basal_metabolism0.31214084
98MP0002928_abnormal_bile_duct0.29338114
99MP0005166_decreased_susceptibility_to0.29046677
100MP0005647_abnormal_sex_gland0.28615040

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.36275481
2Asymmetric septal hypertrophy (HP:0001670)5.87058681
3Absent/shortened dynein arms (HP:0200106)5.74588977
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.74588977
5Bony spicule pigmentary retinopathy (HP:0007737)5.26772680
6Attenuation of retinal blood vessels (HP:0007843)5.12172051
7Bell-shaped thorax (HP:0001591)5.09092656
8Resting tremor (HP:0002322)4.61219108
9Hypoplastic ischia (HP:0003175)4.52561513
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.51857878
11Abnormal ciliary motility (HP:0012262)4.51758042
12Tubulointerstitial nephritis (HP:0001970)4.45035512
13Male infertility (HP:0003251)4.44356634
14Abnormal respiratory motile cilium physiology (HP:0012261)4.42184753
15Hyperkalemia (HP:0002153)4.34072397
16Abnormal respiratory epithelium morphology (HP:0012253)4.27675946
17Abnormal respiratory motile cilium morphology (HP:0005938)4.27675946
18Potter facies (HP:0002009)4.17946886
19Facial shape deformation (HP:0011334)4.17946886
20Infertility (HP:0000789)4.16243555
21Chronic hepatic failure (HP:0100626)4.14986428
22Enlarged epiphyses (HP:0010580)4.07764307
23Abnormality of the ischium (HP:0003174)4.02566981
24Abnormal rod and cone electroretinograms (HP:0008323)3.96414860
25Abnormality of macular pigmentation (HP:0008002)3.93310973
26Impulsivity (HP:0100710)3.76064434
27Nasal polyposis (HP:0100582)3.74184591
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.73277068
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.72037301
30Abnormal spermatogenesis (HP:0008669)3.56226913
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.48613999
32Cone-rod dystrophy (HP:0000548)3.46032803
33Azoospermia (HP:0000027)3.42290583
34Hypoplasia of the thymus (HP:0000778)3.23972635
35Postural instability (HP:0002172)3.14221275
36Abnormality of the nasal mucosa (HP:0000433)2.99797046
37Nephronophthisis (HP:0000090)2.91963402
38Abnormal urine output (HP:0012590)2.89714413
39Epiphyseal dysplasia (HP:0002656)2.77904609
40Unilateral renal agenesis (HP:0000122)2.77024136
41Double outlet right ventricle (HP:0001719)2.74668356
42Congenital malformation of the right heart (HP:0011723)2.74668356
43Generalized aminoaciduria (HP:0002909)2.67948025
44Rhinitis (HP:0012384)2.66200966
45Abnormality of the costochondral junction (HP:0000919)2.64358170
46Hypoalphalipoproteinemia (HP:0003233)2.59663633
47Renal dysplasia (HP:0000110)2.57201127
48Abnormality of potassium homeostasis (HP:0011042)2.56097353
49Progressive cerebellar ataxia (HP:0002073)2.53963677
50Abnormality of the aortic arch (HP:0012303)2.51620557
51Progressive sensorineural hearing impairment (HP:0000408)2.49593528
52Abnormality of renal excretion (HP:0011036)2.48396465
53Amelogenesis imperfecta (HP:0000705)2.47533184
54Portal hypertension (HP:0001409)2.47163742
55Abnormality of the renal medulla (HP:0100957)2.43926001
56Stage 5 chronic kidney disease (HP:0003774)2.41659837
57Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.39866427
58Absent epiphyses (HP:0010577)2.39866427
59Abnormal drinking behavior (HP:0030082)2.37592443
60Polydipsia (HP:0001959)2.37592443
61Truncal obesity (HP:0001956)2.35996176
62Abnormality of dental color (HP:0011073)2.31635601
63Tubulointerstitial abnormality (HP:0001969)2.31497931
64Abnormality of the pubic bones (HP:0003172)2.26858498
65Polyuria (HP:0000103)2.25906271
66Abnormality of the hepatic vasculature (HP:0006707)2.25667808
67Widely patent fontanelles and sutures (HP:0004492)2.23418307
68Ventricular tachycardia (HP:0004756)2.22606216
69Hypophosphatemic rickets (HP:0004912)2.17091711
70Abnormality of the parathyroid morphology (HP:0011766)2.16531570
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13817684
72Renovascular hypertension (HP:0100817)2.12332556
73Recurrent pneumonia (HP:0006532)2.10674727
74Insulin-resistant diabetes mellitus (HP:0000831)2.07688648
75Abnormality of the epiphysis of the femoral head (HP:0010574)2.06605637
76Spastic paraparesis (HP:0002313)2.04365537
77Hyponatremia (HP:0002902)2.00626350
78Bronchiectasis (HP:0002110)2.00409277
79Flattened epiphyses (HP:0003071)1.98343997
80Intellectual disability, moderate (HP:0002342)1.97240764
81Short ribs (HP:0000773)1.96300579
82Menstrual irregularities (HP:0000858)1.95007814
83Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.94300527
84Abnormality of femoral epiphyses (HP:0006499)1.94300527
85Chronic bronchitis (HP:0004469)1.94294652
86Mixed hearing impairment (HP:0000410)1.92989516
87Osteomalacia (HP:0002749)1.90866676
88Protuberant abdomen (HP:0001538)1.88600448
89Vertebral clefting (HP:0008428)1.88086236
90Abnormal ventriculo-arterial connection (HP:0011563)1.85869994
91Transposition of the great arteries (HP:0001669)1.85869994
92Abnormal connection of the cardiac segments (HP:0011545)1.85869994
93Decreased central vision (HP:0007663)1.85708303
94Abnormality of the femoral head (HP:0003368)1.82938484
95Recurrent corneal erosions (HP:0000495)1.80200773
96Occipital encephalocele (HP:0002085)1.77627909
97Tetany (HP:0001281)1.76435847
98Flat capital femoral epiphysis (HP:0003370)1.75657637
99Sensory axonal neuropathy (HP:0003390)1.74177439
100Increased purine levels (HP:0004368)1.71305366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.67852248
2TESK16.33128166
3DDR25.68528692
4INSRR3.42175765
5PLK23.22161978
6STK383.21670480
7PNCK2.80864145
8MAP4K22.52991794
9MAPK152.49143022
10BRD42.46670542
11STK38L2.44385654
12CAMK1G2.29169444
13PRKD32.09411875
14MST1R2.02967473
15TESK21.70345734
16PIK3CG1.58413543
17PDPK11.56291900
18WNK11.51035536
19CDK71.47649059
20PDK11.41354480
21CDK121.30991655
22DYRK1B1.26809606
23NEK61.15415783
24PTK2B1.12888737
25MAP3K91.02245355
26CAMK1D0.95937826
27KSR20.95824964
28LATS20.87638221
29SIK20.82851498
30UHMK10.82161972
31AKT30.80123395
32RPS6KA20.78532785
33MAP3K110.77343258
34PRKG20.76147460
35PRKG10.69834398
36BRAF0.66305103
37RPS6KA10.63918968
38PRKAA20.61550172
39WNK40.59619129
40ROCK10.57412901
41TYRO30.53105814
42MAP3K80.52991707
43MAP2K20.51794739
44STK390.50599409
45MAP3K20.49271113
46RPS6KC10.46820228
47RPS6KL10.46820228
48CAMK10.46721747
49CDK20.45984460
50LATS10.44814476
51GSK3B0.43185256
52RPS6KA60.42322511
53MUSK0.41926646
54JAK30.41533121
55CDK10.38715827
56CDK30.38573219
57MAPK10.38244066
58ARAF0.38097486
59MET0.37640618
60RIPK40.36667301
61MTOR0.33927458
62SGK4940.33778155
63SGK2230.33778155
64PRKCG0.33295074
65CDK40.32751962
66MAPK80.31284917
67NTRK30.29417934
68OXSR10.29320601
69MARK10.29128056
70CAMK40.28482041
71PRKCB0.28102983
72CHEK10.28057207
73PRKCZ0.27893468
74MAP3K10.27848242
75MAPK110.26131240
76FRK0.24906846
77BMPR1B0.24751745
78MAP3K40.24096990
79SGK10.23985528
80MARK20.22764831
81MAPK140.22561962
82MAPK100.20185586
83BRSK10.17203064
84TNIK0.16292013
85FER0.15847320
86DYRK30.14744764
87RIPK10.14663142
88AKT10.14439799
89PKN10.13486078
90PRKCE0.12327871
91PRKACB0.11904954
92MAP3K130.11707268
93TIE10.11022394
94ADRBK20.10584486
95PRKACA0.08880339
96ZAK0.08876670
97ACVR1B0.08629664
98CDK190.08110794
99GRK10.07800923
100PRKAA10.06744822

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.21226718
2Fatty acid biosynthesis_Homo sapiens_hsa000616.11418336
3Olfactory transduction_Homo sapiens_hsa047403.90141374
4Butanoate metabolism_Homo sapiens_hsa006502.37620664
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35201833
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.11112626
7Dorso-ventral axis formation_Homo sapiens_hsa043201.80485452
8Type I diabetes mellitus_Homo sapiens_hsa049401.76833708
9Taste transduction_Homo sapiens_hsa047421.73815106
10Allograft rejection_Homo sapiens_hsa053301.71530444
11Autoimmune thyroid disease_Homo sapiens_hsa053201.67770196
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.62728612
13Fatty acid degradation_Homo sapiens_hsa000711.60971209
14Graft-versus-host disease_Homo sapiens_hsa053321.59829568
15Type II diabetes mellitus_Homo sapiens_hsa049301.58335351
16Phenylalanine metabolism_Homo sapiens_hsa003601.49661550
17Antigen processing and presentation_Homo sapiens_hsa046121.45175984
18Selenocompound metabolism_Homo sapiens_hsa004501.41365525
19Phototransduction_Homo sapiens_hsa047441.36780358
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36268114
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36189993
22Fatty acid metabolism_Homo sapiens_hsa012121.35624259
23Protein digestion and absorption_Homo sapiens_hsa049741.33292483
24RNA transport_Homo sapiens_hsa030131.30483784
25Synaptic vesicle cycle_Homo sapiens_hsa047211.25652237
26Viral myocarditis_Homo sapiens_hsa054161.25283177
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.22529500
28Arginine and proline metabolism_Homo sapiens_hsa003301.18785093
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16918513
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12257348
31Endocytosis_Homo sapiens_hsa041441.10658792
32Salivary secretion_Homo sapiens_hsa049701.05861655
33ABC transporters_Homo sapiens_hsa020101.03103223
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01390865
35Inositol phosphate metabolism_Homo sapiens_hsa005620.97163581
36Calcium signaling pathway_Homo sapiens_hsa040200.95363217
37Renin-angiotensin system_Homo sapiens_hsa046140.93907625
38Morphine addiction_Homo sapiens_hsa050320.92054690
39Arginine biosynthesis_Homo sapiens_hsa002200.90848585
40PPAR signaling pathway_Homo sapiens_hsa033200.90645316
41Oocyte meiosis_Homo sapiens_hsa041140.90217942
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90164194
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.87034066
44cAMP signaling pathway_Homo sapiens_hsa040240.85765434
45Cardiac muscle contraction_Homo sapiens_hsa042600.83876840
46Circadian entrainment_Homo sapiens_hsa047130.83860403
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82007469
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79966067
49Hedgehog signaling pathway_Homo sapiens_hsa043400.78736435
50Nicotine addiction_Homo sapiens_hsa050330.74783400
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.72400437
52Fat digestion and absorption_Homo sapiens_hsa049750.72096755
53Glycerolipid metabolism_Homo sapiens_hsa005610.71000244
54Gastric acid secretion_Homo sapiens_hsa049710.69681329
55Influenza A_Homo sapiens_hsa051640.68265814
56Bile secretion_Homo sapiens_hsa049760.67283130
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66009267
58Tyrosine metabolism_Homo sapiens_hsa003500.65979544
59Estrogen signaling pathway_Homo sapiens_hsa049150.65230847
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63313591
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62830617
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62675456
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59848670
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59353896
65Tight junction_Homo sapiens_hsa045300.57358531
66Retinol metabolism_Homo sapiens_hsa008300.57245686
67Glutamatergic synapse_Homo sapiens_hsa047240.56904868
68Purine metabolism_Homo sapiens_hsa002300.55971778
69Renin secretion_Homo sapiens_hsa049240.55478719
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55323284
71Cholinergic synapse_Homo sapiens_hsa047250.50215521
72Basal transcription factors_Homo sapiens_hsa030220.46747356
73Insulin secretion_Homo sapiens_hsa049110.45117867
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.43544133
75VEGF signaling pathway_Homo sapiens_hsa043700.42967573
76MAPK signaling pathway_Homo sapiens_hsa040100.42243042
77Acute myeloid leukemia_Homo sapiens_hsa052210.39584558
78Serotonergic synapse_Homo sapiens_hsa047260.38999686
79ECM-receptor interaction_Homo sapiens_hsa045120.36896668
80GABAergic synapse_Homo sapiens_hsa047270.36558434
81Pancreatic secretion_Homo sapiens_hsa049720.33966076
82Oxytocin signaling pathway_Homo sapiens_hsa049210.31966880
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28345219
84Prolactin signaling pathway_Homo sapiens_hsa049170.27367614
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.26498499
86Huntingtons disease_Homo sapiens_hsa050160.24718232
87Viral carcinogenesis_Homo sapiens_hsa052030.23520948
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19921167
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19637417
90mRNA surveillance pathway_Homo sapiens_hsa030150.19536868
91Nitrogen metabolism_Homo sapiens_hsa009100.19507275
92Fanconi anemia pathway_Homo sapiens_hsa034600.18803126
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17331543
94Long-term potentiation_Homo sapiens_hsa047200.16637308
95Herpes simplex infection_Homo sapiens_hsa051680.16098076
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14855915
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13852113
98Metabolic pathways_Homo sapiens_hsa011000.13421984
99B cell receptor signaling pathway_Homo sapiens_hsa046620.12810272
100Biosynthesis of amino acids_Homo sapiens_hsa012300.12537559

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