ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.76238466
2	multicellular organism reproduction (GO:0032504)	4.66107602
3	sperm motility (GO:0030317)	4.56267601
4	ubiquinone biosynthetic process (GO:0006744)	4.29047323
5	fucose catabolic process (GO:0019317)	4.20118312
6	L-fucose metabolic process (GO:0042354)	4.20118312
7	L-fucose catabolic process (GO:0042355)	4.20118312
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.16913252
9	fusion of sperm to egg plasma membrane (GO:0007342)	4.11716665
10	ubiquinone metabolic process (GO:0006743)	4.02322133
11	behavioral response to nicotine (GO:0035095)	3.92675042
12	piRNA metabolic process (GO:0034587)	3.90728425
13	maturation of 5.8S rRNA (GO:0000460)	3.87074053
14	RNA localization (GO:0006403)	3.81933237
15	protein polyglutamylation (GO:0018095)	3.72814393
16	pseudouridine synthesis (GO:0001522)	3.67096029
17	indolalkylamine metabolic process (GO:0006586)	3.65435172
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63684937
19	regulation of cilium movement (GO:0003352)	3.60985394
20	DNA deamination (GO:0045006)	3.60071188
21	axoneme assembly (GO:0035082)	3.53112658
22	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	3.51630177
23	cytochrome complex assembly (GO:0017004)	3.49550793
24	protein complex biogenesis (GO:0070271)	3.49229905
25	quinone biosynthetic process (GO:1901663)	3.44502278
26	epithelial cilium movement (GO:0003351)	3.43203195
27	seminiferous tubule development (GO:0072520)	3.40132883
28	rRNA modification (GO:0000154)	3.30956313
29	detection of light stimulus involved in sensory perception (GO:0050962)	3.30940196
30	detection of light stimulus involved in visual perception (GO:0050908)	3.30940196
31	cellular ketone body metabolic process (GO:0046950)	3.29587086
32	plasma membrane fusion (GO:0045026)	3.28692003
33	acrosome reaction (GO:0007340)	3.26761616
34	tryptophan catabolic process (GO:0006569)	3.23260059
35	indole-containing compound catabolic process (GO:0042436)	3.23260059
36	indolalkylamine catabolic process (GO:0046218)	3.23260059
37	reproduction (GO:0000003)	3.20619248
38	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.20337459
39	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.15696513
40	negative regulation of telomere maintenance (GO:0032205)	3.15478833
41	positive regulation of meiosis (GO:0045836)	3.15160558
42	spermatid development (GO:0007286)	3.15102706
43	tryptophan metabolic process (GO:0006568)	3.14289669
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.14206422
45	nonmotile primary cilium assembly (GO:0035058)	3.09828270
46	retinal cone cell development (GO:0046549)	3.09520746
47	ketone body metabolic process (GO:1902224)	3.06142611
48	preassembly of GPI anchor in ER membrane (GO:0016254)	3.04665851
49	male meiosis I (GO:0007141)	3.04115736
50	photoreceptor cell maintenance (GO:0045494)	2.97456077
51	rRNA catabolic process (GO:0016075)	2.96745444
52	sperm-egg recognition (GO:0035036)	2.96056497
53	positive regulation of meiotic cell cycle (GO:0051446)	2.94266938
54	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.94063750
55	respiratory chain complex IV assembly (GO:0008535)	2.92888445
56	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88883489
57	NADH dehydrogenase complex assembly (GO:0010257)	2.88883489
58	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88883489
59	neural tube formation (GO:0001841)	2.84124011
60	regulation of meiosis I (GO:0060631)	2.82308307
61	protein localization to Golgi apparatus (GO:0034067)	2.82031754
62	regulation of glucokinase activity (GO:0033131)	2.76107338
63	regulation of hexokinase activity (GO:1903299)	2.76107338
64	platelet dense granule organization (GO:0060155)	2.75707685
65	kynurenine metabolic process (GO:0070189)	2.75694880
66	dopamine transport (GO:0015872)	2.72884025
67	cilium movement (GO:0003341)	2.72297289
68	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.72210356
69	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.72041153
70	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.72041153
71	rRNA methylation (GO:0031167)	2.71324233
72	protein-cofactor linkage (GO:0018065)	2.68160959
73	positive regulation of signal transduction by p53 class mediator (GO:1901798)	2.66563409
74	establishment of protein localization to Golgi (GO:0072600)	2.65875356
75	gamma-aminobutyric acid transport (GO:0015812)	2.64536610
76	exogenous drug catabolic process (GO:0042738)	2.64500306
77	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.62782747
78	centriole replication (GO:0007099)	2.62621544
79	DNA methylation involved in gamete generation (GO:0043046)	2.62029293
80	male meiosis (GO:0007140)	2.61167242
81	regulation of microtubule-based movement (GO:0060632)	2.59926027
82	negative regulation of mast cell activation (GO:0033004)	2.59780415
83	protein targeting to Golgi (GO:0000042)	2.59721408
84	cornea development in camera-type eye (GO:0061303)	2.58040319
85	S-adenosylmethionine metabolic process (GO:0046500)	2.58010875
86	indole-containing compound metabolic process (GO:0042430)	2.57259365
87	protein localization to cilium (GO:0061512)	2.54476873
88	axonemal dynein complex assembly (GO:0070286)	2.53614251
89	kidney morphogenesis (GO:0060993)	2.53583289
90	GPI anchor metabolic process (GO:0006505)	2.53343720
91	organic cation transport (GO:0015695)	2.53238054
92	regulation of memory T cell differentiation (GO:0043380)	2.52682089
93	mannosylation (GO:0097502)	2.52290673
94	reflex (GO:0060004)	2.50633163
95	single fertilization (GO:0007338)	2.50345638
96	cell-cell recognition (GO:0009988)	2.50151318
97	behavioral response to ethanol (GO:0048149)	2.50119801
98	cilium organization (GO:0044782)	2.49048670
99	amine catabolic process (GO:0009310)	2.48426206
100	cellular biogenic amine catabolic process (GO:0042402)	2.48426206

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.91660049
2	VDR_22108803_ChIP-Seq_LS180_Human	3.02958850
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.63326797
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.51434913
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23979348
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.21280640
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20314508
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.17078009
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.16698847
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14086578
11	FUS_26573619_Chip-Seq_HEK293_Human	1.99901247
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99737878
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.97389381
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93429148
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91865016
16	EZH2_22144423_ChIP-Seq_EOC_Human	1.90763326
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.86963427
18	* P300_19829295_ChIP-Seq_ESCs_Human	1.86916184
19	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84939059
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.78163663
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.78163663
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76992125
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.73761652
24	EWS_26573619_Chip-Seq_HEK293_Human	1.64112404
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.63649987
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.62684182
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61627441
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.60151531
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.58782913
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56469237
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.54915234
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52020938
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51322302
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.50901413
35	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.50901413
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47755803
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45943749
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45943749
39	AR_25329375_ChIP-Seq_VCAP_Human	1.39686739
40	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.39129060
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.38920961
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38309820
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37650608
44	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.35834853
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.33488583
46	STAT3_23295773_ChIP-Seq_U87_Human	1.33206719
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32767064
48	NCOR_22424771_ChIP-Seq_293T_Human	1.32441420
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32261785
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32252858
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32182259
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31218185
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31142841
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31142841
55	AR_20517297_ChIP-Seq_VCAP_Human	1.30550023
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30503855
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28458953
58	NANOG_20526341_ChIP-Seq_ESCs_Human	1.27954417
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27786828
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.27667510
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27409566
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24885086
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24180536
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23601635
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22570669
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.22225956
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.22015327
68	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.21235557
69	TCF4_23295773_ChIP-Seq_U87_Human	1.21147547
70	BCAT_22108803_ChIP-Seq_LS180_Human	1.21017132
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20563529
72	MYC_19829295_ChIP-Seq_ESCs_Human	1.18594943
73	AR_21572438_ChIP-Seq_LNCaP_Human	1.18276857
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17825724
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17792390
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16876068
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16194807
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16190015
79	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15270841
80	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13407574
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13016719
82	ERA_21632823_ChIP-Seq_H3396_Human	1.12390709
83	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11275410
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10190254
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09991549
86	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08935071
87	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.08903471
88	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08111696
89	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.07478996
90	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.07012822
91	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.06133278
92	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04796135
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04198496
94	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.04027222
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02778221
96	OCT4_20526341_ChIP-Seq_ESCs_Human	1.02579639
97	VDR_23849224_ChIP-Seq_CD4+_Human	1.02360922
98	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.02245994
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00500406
100	ETV1_20927104_ChIP-Seq_GIST48_Human	0.99503056

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	3.17778382
2	MP0005410_abnormal_fertilization	2.90907879
3	MP0006292_abnormal_olfactory_placode	2.76354029
4	MP0000372_irregular_coat_pigmentation	2.65061464
5	MP0008877_abnormal_DNA_methylation	2.61771745
6	MP0002102_abnormal_ear_morphology	2.60563308
7	MP0008872_abnormal_physiological_respon	2.43966339
8	MP0001968_abnormal_touch/_nociception	2.43478515
9	MP0003646_muscle_fatigue	2.23954462
10	MP0005084_abnormal_gallbladder_morpholo	2.21336411
11	MP0005551_abnormal_eye_electrophysiolog	2.17793162
12	MP0002638_abnormal_pupillary_reflex	2.13252058
13	MP0005645_abnormal_hypothalamus_physiol	2.10728703
14	MP0003787_abnormal_imprinting	2.06838669
15	MP0004885_abnormal_endolymph	2.03941462
16	MP0005646_abnormal_pituitary_gland	1.92926393
17	MP0002837_dystrophic_cardiac_calcinosis	1.89857144
18	MP0003195_calcinosis	1.89477852
19	MP0005253_abnormal_eye_physiology	1.86907540
20	MP0002736_abnormal_nociception_after	1.84985836
21	MP0004133_heterotaxia	1.83377752
22	MP0005379_endocrine/exocrine_gland_phen	1.76500519
23	MP0008875_abnormal_xenobiotic_pharmacok	1.73495473
24	MP0005075_abnormal_melanosome_morpholog	1.71738216
25	MP0001986_abnormal_taste_sensitivity	1.68637022
26	MP0006072_abnormal_retinal_apoptosis	1.61342286
27	MP0003718_maternal_effect	1.59047478
28	MP0003878_abnormal_ear_physiology	1.57398492
29	MP0005377_hearing/vestibular/ear_phenot	1.57398492
30	MP0000631_abnormal_neuroendocrine_gland	1.55643052
31	MP0002163_abnormal_gland_morphology	1.53159820
32	MP0009745_abnormal_behavioral_response	1.51215799
33	MP0002938_white_spotting	1.50787083
34	MP0003011_delayed_dark_adaptation	1.49808126
35	MP0006276_abnormal_autonomic_nervous	1.48098659
36	MP0004147_increased_porphyrin_level	1.46418776
37	MP0009046_muscle_twitch	1.46385846
38	MP0002234_abnormal_pharynx_morphology	1.45480539
39	MP0003698_abnormal_male_reproductive	1.41892555
40	MP0000569_abnormal_digit_pigmentation	1.41231141
41	MP0001929_abnormal_gametogenesis	1.37837005
42	MP0002272_abnormal_nervous_system	1.37368825
43	MP0003880_abnormal_central_pattern	1.34894200
44	MP0001485_abnormal_pinna_reflex	1.33439233
45	MP0003283_abnormal_digestive_organ	1.32667906
46	MP0002876_abnormal_thyroid_physiology	1.30807230
47	MP0008995_early_reproductive_senescence	1.28978178
48	MP0001486_abnormal_startle_reflex	1.28780930
49	MP0002928_abnormal_bile_duct	1.27241674
50	MP0008775_abnormal_heart_ventricle	1.26690708
51	MP0001905_abnormal_dopamine_level	1.22994090
52	MP0001501_abnormal_sleep_pattern	1.22088873
53	MP0008789_abnormal_olfactory_epithelium	1.20409780
54	MP0008058_abnormal_DNA_repair	1.20024712
55	MP0002095_abnormal_skin_pigmentation	1.18119590
56	MP0001764_abnormal_homeostasis	1.17315284
57	MP0004142_abnormal_muscle_tone	1.17186951
58	MP0001984_abnormal_olfaction	1.13468525
59	MP0001529_abnormal_vocalization	1.13178125
60	MP0010386_abnormal_urinary_bladder	1.11333533
61	MP0000427_abnormal_hair_cycle	1.08063878
62	MP0000049_abnormal_middle_ear	1.06313126
63	MP0002735_abnormal_chemical_nociception	1.06232613
64	MP0005389_reproductive_system_phenotype	1.06216452
65	MP0002160_abnormal_reproductive_system	1.05568444
66	MP0001502_abnormal_circadian_rhythm	1.05082907
67	MP0003137_abnormal_impulse_conducting	1.02812534
68	MP0000613_abnormal_salivary_gland	1.02596945
69	MP0004145_abnormal_muscle_electrophysio	1.01022745
70	MP0004924_abnormal_behavior	1.00664030
71	MP0005386_behavior/neurological_phenoty	1.00664030
72	MP0002572_abnormal_emotion/affect_behav	1.00499523
73	MP0002733_abnormal_thermal_nociception	1.00144027
74	MP0002557_abnormal_social/conspecific_i	0.98729634
75	MP0000230_abnormal_systemic_arterial	0.98250885
76	MP0002751_abnormal_autonomic_nervous	0.97212477
77	MP0002210_abnormal_sex_determination	0.95597022
78	MP0009764_decreased_sensitivity_to	0.94786703
79	MP0003121_genomic_imprinting	0.94623905
80	MP0000653_abnormal_sex_gland	0.89450945
81	MP0001970_abnormal_pain_threshold	0.88542884
82	MP0004742_abnormal_vestibular_system	0.88227419
83	MP0009697_abnormal_copulation	0.86986667
84	MP0002653_abnormal_ependyma_morphology	0.86071309
85	MP0005195_abnormal_posterior_eye	0.85817184
86	MP0006035_abnormal_mitochondrial_morpho	0.84935339
87	MP0005167_abnormal_blood-brain_barrier	0.83457820
88	MP0004215_abnormal_myocardial_fiber	0.80069049
89	MP0004043_abnormal_pH_regulation	0.80060585
90	MP0003252_abnormal_bile_duct	0.79951256
91	MP0002254_reproductive_system_inflammat	0.79150428
92	MP0005365_abnormal_bile_salt	0.79004770
93	MP0001145_abnormal_male_reproductive	0.78818597
94	MP0001293_anophthalmia	0.78812695
95	MP0003136_yellow_coat_color	0.77817123
96	MP0000015_abnormal_ear_pigmentation	0.76414735
97	MP0005394_taste/olfaction_phenotype	0.75136048
98	MP0005499_abnormal_olfactory_system	0.75136048
99	MP0005083_abnormal_biliary_tract	0.74943199
100	MP0002067_abnormal_sensory_capabilities	0.74885094

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.01830299
2	Pancreatic cysts (HP:0001737)	3.99329475
3	Abnormality of the renal cortex (HP:0011035)	3.87165525
4	Pancreatic fibrosis (HP:0100732)	3.73366571
5	Concave nail (HP:0001598)	3.67329233
6	Abnormality of midbrain morphology (HP:0002418)	3.67043892
7	Molar tooth sign on MRI (HP:0002419)	3.67043892
8	Nephronophthisis (HP:0000090)	3.57166338
9	Attenuation of retinal blood vessels (HP:0007843)	3.47351932
10	True hermaphroditism (HP:0010459)	3.45720428
11	Abnormality of the renal medulla (HP:0100957)	3.43867735
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.34569072
13	Chronic hepatic failure (HP:0100626)	3.19236089
14	Abnormal drinking behavior (HP:0030082)	3.14888590
15	Polydipsia (HP:0001959)	3.14888590
16	Pendular nystagmus (HP:0012043)	3.01239275
17	Congenital, generalized hypertrichosis (HP:0004540)	2.98494417
18	Abolished electroretinogram (ERG) (HP:0000550)	2.91936099
19	Hyperventilation (HP:0002883)	2.90029707
20	Renal cortical cysts (HP:0000803)	2.86843816
21	3-Methylglutaconic aciduria (HP:0003535)	2.76857952
22	Medial flaring of the eyebrow (HP:0010747)	2.74576050
23	Polyuria (HP:0000103)	2.72975243
24	Stomach cancer (HP:0012126)	2.71134455
25	Type II lissencephaly (HP:0007260)	2.70252344
26	Decreased central vision (HP:0007663)	2.66778854
27	Tubular atrophy (HP:0000092)	2.58451314
28	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.57605443
29	Bony spicule pigmentary retinopathy (HP:0007737)	2.53795618
30	Acute necrotizing encephalopathy (HP:0006965)	2.47447477
31	Increased corneal curvature (HP:0100692)	2.47164376
32	Keratoconus (HP:0000563)	2.47164376
33	Mitochondrial inheritance (HP:0001427)	2.46049503
34	Cystic liver disease (HP:0006706)	2.44159353
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39884520
36	Absent/shortened dynein arms (HP:0200106)	2.39884520
37	Increased CSF lactate (HP:0002490)	2.36503001
38	Abnormal urine output (HP:0012590)	2.31866110
39	Fair hair (HP:0002286)	2.31423538
40	Congenital hepatic fibrosis (HP:0002612)	2.30955946
41	Progressive macrocephaly (HP:0004481)	2.25808136
42	Tubulointerstitial abnormality (HP:0001969)	2.25710334
43	Severe visual impairment (HP:0001141)	2.25533608
44	Abnormality of B cell number (HP:0010975)	2.21059941
45	Optic disc pallor (HP:0000543)	2.18792374
46	Acute encephalopathy (HP:0006846)	2.18329956
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.14103850
48	Tubulointerstitial fibrosis (HP:0005576)	2.12122522
49	Colon cancer (HP:0003003)	2.11779945
50	Sclerocornea (HP:0000647)	2.11419080
51	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.09740978
52	Hepatocellular necrosis (HP:0001404)	2.05981055
53	Oligodactyly (hands) (HP:0001180)	2.04630832
54	Tubulointerstitial nephritis (HP:0001970)	2.03768925
55	Abnormal biliary tract physiology (HP:0012439)	2.02884815
56	Bile duct proliferation (HP:0001408)	2.02884815
57	Optic nerve hypoplasia (HP:0000609)	2.02643578
58	Hypomagnesemia (HP:0002917)	2.02394430
59	Methylmalonic acidemia (HP:0002912)	2.01653002
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.97430076
61	Hyperglycinemia (HP:0002154)	1.97359613
62	Abnormality of macular pigmentation (HP:0008002)	1.94145277
63	Abnormality of renal excretion (HP:0011036)	1.93120917
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.92120239
65	Abnormal respiratory epithelium morphology (HP:0012253)	1.91962477
66	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91962477
67	Hepatic necrosis (HP:0002605)	1.91086795
68	Abnormality of alanine metabolism (HP:0010916)	1.88956635
69	Hyperalaninemia (HP:0003348)	1.88956635
70	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88956635
71	Congenital primary aphakia (HP:0007707)	1.88165303
72	Male pseudohermaphroditism (HP:0000037)	1.88125093
73	Asplenia (HP:0001746)	1.88091723
74	Gait imbalance (HP:0002141)	1.87434282
75	Ketosis (HP:0001946)	1.87405155
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87196623
77	Mesangial abnormality (HP:0001966)	1.87027906
78	Amelogenesis imperfecta (HP:0000705)	1.86423352
79	Abnormal ciliary motility (HP:0012262)	1.85878209
80	Occipital encephalocele (HP:0002085)	1.84313184
81	Inability to walk (HP:0002540)	1.83302242
82	Type 2 muscle fiber atrophy (HP:0003554)	1.82959591
83	Cerebellar dysplasia (HP:0007033)	1.79596001
84	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.79514140
85	Hypoplasia of the fovea (HP:0007750)	1.79514140
86	Hypothermia (HP:0002045)	1.77638371
87	Nephrogenic diabetes insipidus (HP:0009806)	1.76962507
88	Gaze-evoked nystagmus (HP:0000640)	1.76529080
89	Aplasia/hypoplasia of the uterus (HP:0008684)	1.75443309
90	Increased serum lactate (HP:0002151)	1.75046671
91	Postaxial foot polydactyly (HP:0001830)	1.74501302
92	Generalized hypopigmentation of hair (HP:0011358)	1.74196910
93	Cone-rod dystrophy (HP:0000548)	1.70945522
94	Focal motor seizures (HP:0011153)	1.70326516
95	Photophobia (HP:0000613)	1.69163895
96	Elevated erythrocyte sedimentation rate (HP:0003565)	1.68763074
97	Genital tract atresia (HP:0001827)	1.68741384
98	Progressive inability to walk (HP:0002505)	1.67558011
99	Hemiparesis (HP:0001269)	1.66891321
100	Constricted visual fields (HP:0001133)	1.66456237

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.38281117
2	NUAK1	3.18732135
3	ADRBK2	3.06718430
4	ZAK	2.85985623
5	BMPR1B	2.81827221
6	TLK1	2.70320142
7	MAP4K2	2.70131146
8	INSRR	2.59067814
9	PINK1	2.57018834
10	TAOK3	2.30767084
11	GRK1	2.25589757
12	PLK4	2.16742405
13	STK38L	2.01643402
14	PLK2	1.93574659
15	WNK3	1.91430301
16	VRK2	1.69143612
17	VRK1	1.51071899
18	TNIK	1.47444328
19	WNK4	1.46645652
20	CASK	1.45459626
21	MAPKAPK3	1.43207969
22	MAPK13	1.43076488
23	OXSR1	1.37812055
24	TIE1	1.32418037
25	PRKCE	1.28989907
26	MUSK	1.26828842
27	PRKCI	1.22896183
28	KIT	1.21082103
29	CSNK1G3	1.17609773
30	PRKCG	1.14744506
31	CSNK1G1	1.14429202
32	CSNK1G2	1.12731691
33	TEC	1.07907776
34	MAP3K4	1.05272376
35	STK16	1.03885076
36	PTK2B	0.95040652
37	EPHA4	0.95026999
38	PNCK	0.89805138
39	TRIM28	0.87636731
40	MAP2K7	0.87302606
41	IKBKB	0.86798152
42	STK39	0.86656747
43	FLT3	0.86223746
44	PLK3	0.85789809
45	RIPK1	0.85214693
46	PDK2	0.83409989
47	DYRK2	0.82970313
48	DAPK2	0.80786233
49	PAK3	0.80343529
50	ADRBK1	0.76766098
51	ERBB3	0.73271932
52	TXK	0.72554818
53	PIK3CG	0.71405439
54	BCKDK	0.71319246
55	EIF2AK3	0.69257221
56	MST4	0.68650080
57	PASK	0.68293655
58	MAPK15	0.67850054
59	TGFBR1	0.67057881
60	PHKG2	0.65916255
61	PHKG1	0.65916255
62	STK38	0.61594304
63	PRKCQ	0.61085424
64	TNK2	0.60748090
65	ITK	0.60545710
66	CSNK1A1L	0.59352123
67	NLK	0.59255065
68	FGFR2	0.59052365
69	PIK3CA	0.57908668
70	CDK8	0.57164861
71	BCR	0.56810923
72	MAP3K12	0.53029580
73	RPS6KA5	0.50803168
74	MAP4K1	0.50543758
75	TAF1	0.49921923
76	CSNK1A1	0.49311685
77	EIF2AK1	0.49294226
78	MAPKAPK5	0.49040683
79	NTRK3	0.48615909
80	FER	0.46272155
81	PRKACA	0.43627431
82	PRKCZ	0.43225679
83	SYK	0.43119997
84	PRKCA	0.41716772
85	PKN1	0.41662283
86	CAMK2A	0.41360832
87	GRK5	0.40725691
88	CSNK1D	0.40094304
89	STK3	0.40090425
90	SIK2	0.39522752
91	NME1	0.38777693
92	PRKCH	0.37885930
93	PLK1	0.37863816
94	EPHA3	0.37592951
95	BMPR2	0.37219130
96	CAMK1	0.35794552
97	SRPK1	0.35362382
98	OBSCN	0.35308115
99	PRKG1	0.34864992
100	MKNK1	0.33488372

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.19914359
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.88288150
3	Caffeine metabolism_Homo sapiens_hsa00232	2.88214091
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.47107658
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.46972163
6	Phototransduction_Homo sapiens_hsa04744	2.40178022
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.28036546
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20227462
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.13072703
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.06128693
11	Butanoate metabolism_Homo sapiens_hsa00650	2.04507839
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.86892163
13	Asthma_Homo sapiens_hsa05310	1.77664851
14	Protein export_Homo sapiens_hsa03060	1.73060334
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.69982155
16	Parkinsons disease_Homo sapiens_hsa05012	1.68819955
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.66575334
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.61943373
19	Olfactory transduction_Homo sapiens_hsa04740	1.61355513
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.61308313
21	Proteasome_Homo sapiens_hsa03050	1.61204626
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58637040
23	Homologous recombination_Homo sapiens_hsa03440	1.56956511
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54020145
25	RNA degradation_Homo sapiens_hsa03018	1.50428669
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.48783496
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.43310706
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.42349394
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.40898410
30	Graft-versus-host disease_Homo sapiens_hsa05332	1.37768846
31	RNA polymerase_Homo sapiens_hsa03020	1.31544525
32	Allograft rejection_Homo sapiens_hsa05330	1.29280649
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.23363830
34	Propanoate metabolism_Homo sapiens_hsa00640	1.22983949
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.21213010
36	Taste transduction_Homo sapiens_hsa04742	1.20848043
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20069601
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.18294871
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.17814517
40	Peroxisome_Homo sapiens_hsa04146	1.15208056
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.13005777
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.12847816
43	Nicotine addiction_Homo sapiens_hsa05033	1.10515465
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08829973
45	Basal transcription factors_Homo sapiens_hsa03022	1.08108689
46	Huntingtons disease_Homo sapiens_hsa05016	1.06799548
47	One carbon pool by folate_Homo sapiens_hsa00670	1.06792542
48	Regulation of autophagy_Homo sapiens_hsa04140	1.03893282
49	Retinol metabolism_Homo sapiens_hsa00830	1.03655984
50	Sulfur relay system_Homo sapiens_hsa04122	1.01314187
51	Alzheimers disease_Homo sapiens_hsa05010	0.97879226
52	Antigen processing and presentation_Homo sapiens_hsa04612	0.97184857
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.96498513
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.96338675
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.88905039
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.88827775
57	Ribosome_Homo sapiens_hsa03010	0.88238654
58	Non-homologous end-joining_Homo sapiens_hsa03450	0.88097239
59	Tyrosine metabolism_Homo sapiens_hsa00350	0.84745451
60	Salivary secretion_Homo sapiens_hsa04970	0.82954014
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81306842
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.80040134
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73601336
64	Morphine addiction_Homo sapiens_hsa05032	0.72838284
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72292532
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69997017
67	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.69448872
68	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.68115210
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66860554
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66265102
71	Fatty acid degradation_Homo sapiens_hsa00071	0.65575264
72	Metabolic pathways_Homo sapiens_hsa01100	0.64826110
73	Purine metabolism_Homo sapiens_hsa00230	0.63555798
74	Base excision repair_Homo sapiens_hsa03410	0.63123523
75	Insulin secretion_Homo sapiens_hsa04911	0.60893692
76	Rheumatoid arthritis_Homo sapiens_hsa05323	0.58490628
77	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.56785845
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55465359
79	ABC transporters_Homo sapiens_hsa02010	0.54863968
80	Circadian entrainment_Homo sapiens_hsa04713	0.54511542
81	Serotonergic synapse_Homo sapiens_hsa04726	0.52708633
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52550157
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52385012
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.51932689
85	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51572703
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.49893828
87	RNA transport_Homo sapiens_hsa03013	0.49785052
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48282224
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47954438
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.45696397
91	Mineral absorption_Homo sapiens_hsa04978	0.44355925
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44111328
93	Lysine degradation_Homo sapiens_hsa00310	0.43273719
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42030876
95	GABAergic synapse_Homo sapiens_hsa04727	0.39294163
96	Mismatch repair_Homo sapiens_hsa03430	0.36624674
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36223250
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34376977
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.34313633
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33665686

GOLGA6L1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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