ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	9.11079463
2	chromosome condensation (GO:0030261)	9.04733587
3	DNA packaging (GO:0006323)	8.76686965
4	single strand break repair (GO:0000012)	8.51605439
5	spermatid nucleus differentiation (GO:0007289)	8.45901636
6	plasma membrane fusion (GO:0045026)	7.95581642
7	spermatid development (GO:0007286)	7.71820034
8	microtubule depolymerization (GO:0007019)	7.57100858
9	sperm-egg recognition (GO:0035036)	7.11205494
10	multicellular organism reproduction (GO:0032504)	6.63743795
11	axonemal dynein complex assembly (GO:0070286)	6.58861781
12	protein polyglutamylation (GO:0018095)	6.54977892
13	binding of sperm to zona pellucida (GO:0007339)	6.40573748
14	sexual reproduction (GO:0019953)	6.39516875
15	rRNA methylation (GO:0031167)	6.36219856
16	calcium ion-dependent exocytosis (GO:0017156)	6.34308266
17	reproduction (GO:0000003)	6.34054673
18	microtubule polymerization or depolymerization (GO:0031109)	6.30815362
19	protein targeting to Golgi (GO:0000042)	6.11799377
20	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.09077853
21	establishment of protein localization to Golgi (GO:0072600)	5.92951768
22	cell-cell recognition (GO:0009988)	5.83540216
23	negative regulation of inclusion body assembly (GO:0090084)	5.73428751
24	spermatogenesis (GO:0007283)	5.73124033
25	male gamete generation (GO:0048232)	5.71325552
26	centriole replication (GO:0007099)	5.69125731
27	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.68737358
28	phosphatidylethanolamine metabolic process (GO:0046337)	5.62369078
29	cellular ketone body metabolic process (GO:0046950)	5.42991108
30	rRNA modification (GO:0000154)	5.37266012
31	regulation of cilium movement (GO:0003352)	5.33953872
32	microtubule severing (GO:0051013)	5.33259259
33	regulation of Rab GTPase activity (GO:0032313)	5.26657740
34	positive regulation of Rab GTPase activity (GO:0032851)	5.26657740
35	gamete generation (GO:0007276)	5.22840489
36	cilium or flagellum-dependent cell motility (GO:0001539)	4.87486202
37	regulation of transcription involved in cell fate commitment (GO:0060850)	4.80792836
38	ketone body metabolic process (GO:1902224)	4.77088268
39	motile cilium assembly (GO:0044458)	4.76381968
40	chromatin silencing (GO:0006342)	4.74504776
41	centriole assembly (GO:0098534)	4.74341776
42	cell wall macromolecule catabolic process (GO:0016998)	4.61046553
43	single fertilization (GO:0007338)	4.55026100
44	RNA destabilization (GO:0050779)	4.54509994
45	epithelial cilium movement (GO:0003351)	4.54329329
46	cell wall macromolecule metabolic process (GO:0044036)	4.54238256
47	protein localization to Golgi apparatus (GO:0034067)	4.51711091
48	regulation of centriole replication (GO:0046599)	4.48331187
49	germ cell development (GO:0007281)	4.37632349
50	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.32455224
51	regulation of inclusion body assembly (GO:0090083)	4.21743083
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.20861314
53	multicellular organismal reproductive process (GO:0048609)	4.16460577
54	coenzyme catabolic process (GO:0009109)	4.04135595
55	cilium movement (GO:0003341)	3.94295533
56	nucleus organization (GO:0006997)	3.90655086
57	fertilization (GO:0009566)	3.80437641
58	regulation of microtubule-based movement (GO:0060632)	3.80434295
59	seminiferous tubule development (GO:0072520)	3.76855878
60	negative regulation of Rho protein signal transduction (GO:0035024)	3.67555984
61	musculoskeletal movement (GO:0050881)	3.56894510
62	multicellular organismal movement (GO:0050879)	3.56894510
63	organic cation transport (GO:0015695)	3.51247486
64	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.39373717
65	peptidyl-threonine dephosphorylation (GO:0035970)	3.38927083
66	negative regulation of gene expression, epigenetic (GO:0045814)	3.35706076
67	regulation of somitogenesis (GO:0014807)	3.34139587
68	glycerol ether metabolic process (GO:0006662)	3.33696156
69	cerebral cortex neuron differentiation (GO:0021895)	3.33405404
70	nucleosome disassembly (GO:0006337)	3.31280080
71	protein-DNA complex disassembly (GO:0032986)	3.31280080
72	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.24338714
73	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.20830969
74	cranial nerve morphogenesis (GO:0021602)	3.20460884
75	polyamine biosynthetic process (GO:0006596)	3.12579294
76	response to acidic pH (GO:0010447)	3.10629621
77	ether metabolic process (GO:0018904)	3.07174838
78	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.06889827
79	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.06889827
80	histone H3-K9 demethylation (GO:0033169)	3.06385978
81	cell recognition (GO:0008037)	3.03830687
82	negative regulation of histone methylation (GO:0031061)	3.03743360
83	cellular response to pH (GO:0071467)	3.00795161
84	microtubule nucleation (GO:0007020)	2.92228025
85	multicellular organismal development (GO:0007275)	2.91833507
86	DNA conformation change (GO:0071103)	2.88132163
87	homeostasis of number of cells within a tissue (GO:0048873)	2.82888747
88	Golgi to endosome transport (GO:0006895)	2.82850950
89	regulation of interleukin-13 production (GO:0032656)	2.82782913
90	protein depolymerization (GO:0051261)	2.79889193
91	histone exchange (GO:0043486)	2.79111216
92	cell differentiation involved in metanephros development (GO:0072202)	2.78772711
93	male meiosis I (GO:0007141)	2.76586269
94	pattern specification involved in kidney development (GO:0061004)	2.73641043
95	spinal cord motor neuron differentiation (GO:0021522)	2.71459474
96	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.69340300
97	acrosome reaction (GO:0007340)	11.7125255
98	sperm motility (GO:0030317)	11.1681615
99	fusion of sperm to egg plasma membrane (GO:0007342)	10.3699557
100	response to pheromone (GO:0019236)	10.0529171

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.85764690
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.01098129
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.69285901
4	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.52573869
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.52573869
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.48881908
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.47019388
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.25479124
9	CBP_20019798_ChIP-Seq_JUKART_Human	2.24240955
10	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.24240955
11	FUS_26573619_Chip-Seq_HEK293_Human	2.19667945
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92321391
13	* ERA_21632823_ChIP-Seq_H3396_Human	1.90549930
14	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.86768261
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86710403
16	DROSHA_22980978_ChIP-Seq_HELA_Human	1.86691211
17	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.85796457
18	NANOG_20526341_ChIP-Seq_ESCs_Human	1.82609952
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.82465391
20	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.82245549
21	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.82167980
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.80253206
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.76604490
24	* EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.75955635
25	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73121954
26	RAC3_21632823_ChIP-Seq_H3396_Human	1.72908890
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.71301528
28	CTCF_27219007_Chip-Seq_Bcells_Human	1.64905283
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.61216425
30	MYC_19829295_ChIP-Seq_ESCs_Human	1.60311011
31	TAF2_19829295_ChIP-Seq_ESCs_Human	1.60213873
32	AR_25329375_ChIP-Seq_VCAP_Human	1.57256246
33	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.54831651
34	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.54751096
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53441478
36	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.52837254
37	* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.50485503
38	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.49052974
39	E2F1_20622854_ChIP-Seq_HELA_Human	1.48330645
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.48247872
41	BCL6_27268052_Chip-Seq_Bcells_Human	1.45623045
42	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.45318197
43	OCT4_20526341_ChIP-Seq_ESCs_Human	1.45172890
44	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.43595291
45	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.43475674
46	PHF8_20622854_ChIP-Seq_HELA_Human	1.42613895
47	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.42573175
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40614043
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39708030
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36981548
51	* P300_19829295_ChIP-Seq_ESCs_Human	1.36547553
52	AR_21572438_ChIP-Seq_LNCaP_Human	1.36372317
53	CTCF_20526341_ChIP-Seq_ESCs_Human	1.35439630
54	ERG_20517297_ChIP-Seq_VCAP_Human	1.33131253
55	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.32744817
56	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.32504659
57	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.31033355
58	P68_20966046_ChIP-Seq_HELA_Human	1.30363039
59	* SMC4_20622854_ChIP-Seq_HELA_Human	1.30096810
60	* SMAD3_21741376_ChIP-Seq_ESCs_Human	1.29443220
61	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.28646574
62	RBPJ_21746931_ChIP-Seq_IB4_Human	1.28024488
63	BCOR_27268052_Chip-Seq_Bcells_Human	1.27826639
64	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.27664694
65	ETV1_20927104_ChIP-Seq_GIST48_Human	1.26889986
66	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.26885274
67	TP53_18474530_ChIP-ChIP_U2OS_Human	1.26264085
68	TP63_22573176_ChIP-Seq_HFKS_Human	1.25203014
69	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24991736
70	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.24125748
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23026682
72	P300_27268052_Chip-Seq_Bcells_Human	1.21672983
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21646210
74	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.21501783
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21232232
76	P53_21459846_ChIP-Seq_SAOS-2_Human	1.19880809
77	CEBPB_22108803_ChIP-Seq_LS180_Human	1.19562549
78	NFYB_21822215_ChIP-Seq_K562_Human	1.19338636
79	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18358226
80	TBL1_22424771_ChIP-Seq_293T_Human	1.17797889
81	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.14576981
82	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.14421478
83	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.13149911
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12951965
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12951965
86	VDR_22108803_ChIP-Seq_LS180_Human	1.11861247
87	PHF8_20622853_ChIP-Seq_HELA_Human	1.11650018
88	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.11465782
89	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.09877603
90	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.09077443
91	SMRT_27268052_Chip-Seq_Bcells_Human	1.08652611
92	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08477545
93	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07916550
94	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07462429
95	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06743244
96	STAT3_23295773_ChIP-Seq_U87_Human	1.06346097
97	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.06195980
98	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.05242947
99	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.05186078
100	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.05168831

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	4.79795841
2	MP0005377_hearing/vestibular/ear_phenot	4.79795841
3	MP0003698_abnormal_male_reproductive	4.23766724
4	MP0005670_abnormal_white_adipose	3.92051422
5	MP0001929_abnormal_gametogenesis	3.58969038
6	MP0001348_abnormal_lacrimal_gland	3.28475163
7	MP0000678_abnormal_parathyroid_gland	2.42249394
8	MP0002161_abnormal_fertility/fecundity	2.39211578
9	MP0003011_delayed_dark_adaptation	2.25644976
10	MP0003718_maternal_effect	2.15557431
11	MP0002234_abnormal_pharynx_morphology	2.13689253
12	MP0005379_endocrine/exocrine_gland_phen	2.00369086
13	MP0005410_abnormal_fertilization	11.2571243
14	MP0005423_abnormal_somatic_nervous	1.83146125
15	MP0002132_abnormal_respiratory_system	1.79637058
16	MP0002822_catalepsy	1.78005515
17	MP0001485_abnormal_pinna_reflex	1.73437876
18	MP0006292_abnormal_olfactory_placode	1.70388641
19	MP0002249_abnormal_larynx_morphology	1.70256074
20	MP0002210_abnormal_sex_determination	1.69757406
21	MP0003646_muscle_fatigue	1.66850413
22	MP0001486_abnormal_startle_reflex	1.57043276
23	MP0002282_abnormal_trachea_morphology	1.50919656
24	MP0009053_abnormal_anal_canal	1.45097873
25	MP0001968_abnormal_touch/_nociception	1.44760373
26	MP0004742_abnormal_vestibular_system	1.44580022
27	MP0003880_abnormal_central_pattern	1.42132029
28	MP0001145_abnormal_male_reproductive	1.40850939
29	MP0002735_abnormal_chemical_nociception	1.40382259
30	MP0000534_abnormal_ureter_morphology	1.34578411
31	MP0000653_abnormal_sex_gland	1.34460317
32	MP0000566_synostosis	1.30464183
33	MP0004859_abnormal_synaptic_plasticity	1.28781607
34	MP0008877_abnormal_DNA_methylation	1.24833473
35	MP0000026_abnormal_inner_ear	1.21697508
36	MP0002138_abnormal_hepatobiliary_system	1.20199640
37	MP0000049_abnormal_middle_ear	1.19003814
38	MP0001963_abnormal_hearing_physiology	1.15376659
39	MP0000955_abnormal_spinal_cord	1.08414824
40	MP0002127_abnormal_cardiovascular_syste	1.05071129
41	MP0005248_abnormal_Harderian_gland	1.01092478
42	MP0002653_abnormal_ependyma_morphology	1.00287448
43	MP0001765_abnormal_ion_homeostasis	0.99005299
44	MP0004510_myositis	0.97742854
45	MP0005551_abnormal_eye_electrophysiolog	0.94661339
46	MP0002557_abnormal_social/conspecific_i	0.93133529
47	MP0005395_other_phenotype	0.89143203
48	MP0000516_abnormal_urinary_system	0.88747665
49	MP0005367_renal/urinary_system_phenotyp	0.88747665
50	MP0002067_abnormal_sensory_capabilities	0.88603695
51	MP0002733_abnormal_thermal_nociception	0.85165771
52	MP0003119_abnormal_digestive_system	0.83025609
53	MP0005310_abnormal_salivary_gland	0.82785870
54	MP0002229_neurodegeneration	0.82289678
55	MP0003879_abnormal_hair_cell	0.80735998
56	MP0005253_abnormal_eye_physiology	0.77281656
57	MP0002572_abnormal_emotion/affect_behav	0.76401433
58	MP0001905_abnormal_dopamine_level	0.76194813
59	MP0004085_abnormal_heartbeat	0.74586844
60	MP0001879_abnormal_lymphatic_vessel	0.74170486
61	MP0009697_abnormal_copulation	0.74051128
62	MP0008995_early_reproductive_senescence	0.73492035
63	MP0005084_abnormal_gallbladder_morpholo	0.72040061
64	MP0009745_abnormal_behavioral_response	0.72000731
65	MP0002272_abnormal_nervous_system	0.71629168
66	MP0000681_abnormal_thyroid_gland	0.70956930
67	MP0005408_hypopigmentation	0.70570064
68	MP0002734_abnormal_mechanical_nocicepti	0.69014449
69	MP0002928_abnormal_bile_duct	0.68278583
70	MP0008569_lethality_at_weaning	0.66981267
71	MP0000569_abnormal_digit_pigmentation	0.65455344
72	MP0001293_anophthalmia	0.64924394
73	MP0001970_abnormal_pain_threshold	0.64091520
74	MP0001440_abnormal_grooming_behavior	0.61242792
75	MP0005636_abnormal_mineral_homeostasis	0.60077562
76	MP0004484_altered_response_of	0.59373446
77	MP0001529_abnormal_vocalization	0.56782079
78	MP0003136_yellow_coat_color	0.56506388
79	MP0001666_abnormal_nutrient_absorption	0.55647603
80	MP0003635_abnormal_synaptic_transmissio	0.54901010
81	MP0006276_abnormal_autonomic_nervous	0.54799729
82	MP0005666_abnormal_adipose_tissue	0.54769914
83	MP0005167_abnormal_blood-brain_barrier	0.53900954
84	MP0000778_abnormal_nervous_system	0.53262656
85	MP0008961_abnormal_basal_metabolism	0.52406291
86	MP0009115_abnormal_fat_cell	0.51951633
87	MP0000613_abnormal_salivary_gland	0.51354177
88	MP0005391_vision/eye_phenotype	0.51155963
89	MP0003936_abnormal_reproductive_system	0.49948575
90	MP0003283_abnormal_digestive_organ	0.49859362
91	MP0003137_abnormal_impulse_conducting	0.49695150
92	MP0001984_abnormal_olfaction	0.48859341
93	MP0003861_abnormal_nervous_system	0.47651769
94	MP0008789_abnormal_olfactory_epithelium	0.47481480
95	MP0002882_abnormal_neuron_morphology	0.47363470
96	MP0005375_adipose_tissue_phenotype	0.46499179
97	MP0003942_abnormal_urinary_system	0.46228146
98	MP0001501_abnormal_sleep_pattern	0.45989396
99	MP0003699_abnormal_female_reproductive	0.45599323
100	MP0002752_abnormal_somatic_nervous	0.45112779

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.76833117
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.10267946
3	Absent/shortened dynein arms (HP:0200106)	6.10267946
4	Abnormal ciliary motility (HP:0012262)	4.92695751
5	Bony spicule pigmentary retinopathy (HP:0007737)	4.88592545
6	Attenuation of retinal blood vessels (HP:0007843)	4.87430535
7	Abnormal respiratory epithelium morphology (HP:0012253)	4.71214197
8	Abnormal respiratory motile cilium morphology (HP:0005938)	4.71214197
9	Abnormal respiratory motile cilium physiology (HP:0012261)	4.66131117
10	Asymmetric septal hypertrophy (HP:0001670)	4.40851681
11	Chronic hepatic failure (HP:0100626)	4.25816126
12	Bell-shaped thorax (HP:0001591)	4.23534273
13	Abnormal rod and cone electroretinograms (HP:0008323)	4.07061607
14	Tubulointerstitial nephritis (HP:0001970)	4.01370698
15	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.96898729
16	Infertility (HP:0000789)	3.94151047
17	Potter facies (HP:0002009)	3.93188257
18	Facial shape deformation (HP:0011334)	3.93188257
19	Hypoplastic ischia (HP:0003175)	3.87683621
20	Hyperkalemia (HP:0002153)	3.85131937
21	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.82701246
22	Abnormality of macular pigmentation (HP:0008002)	3.78715159
23	Male infertility (HP:0003251)	3.68447357
24	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.67053482
25	Resting tremor (HP:0002322)	3.62690890
26	Enlarged epiphyses (HP:0010580)	3.53897369
27	Impulsivity (HP:0100710)	3.47902424
28	Nasal polyposis (HP:0100582)	3.44139206
29	Azoospermia (HP:0000027)	3.42902587
30	Abnormality of the ischium (HP:0003174)	3.39725844
31	Abnormal spermatogenesis (HP:0008669)	3.30947063
32	Nephronophthisis (HP:0000090)	3.24713008
33	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.22554336
34	Abnormal urine output (HP:0012590)	3.03567880
35	Cone-rod dystrophy (HP:0000548)	3.01235935
36	Unilateral renal agenesis (HP:0000122)	2.93668907
37	Renal dysplasia (HP:0000110)	2.93239045
38	Abnormality of the aortic arch (HP:0012303)	2.91254601
39	Abnormal drinking behavior (HP:0030082)	2.85910013
40	Polydipsia (HP:0001959)	2.85910013
41	Congenital malformation of the right heart (HP:0011723)	2.84821294
42	Double outlet right ventricle (HP:0001719)	2.84821294
43	Progressive cerebellar ataxia (HP:0002073)	2.84258501
44	Abnormality of the renal medulla (HP:0100957)	2.75219049
45	Abnormality of the nasal mucosa (HP:0000433)	2.67552044
46	Rhinitis (HP:0012384)	2.66688175
47	Polyuria (HP:0000103)	2.62397378
48	Postural instability (HP:0002172)	2.62270894
49	Abnormality of renal excretion (HP:0011036)	2.60558222
50	Generalized aminoaciduria (HP:0002909)	2.48792462
51	Abnormality of the pubic bones (HP:0003172)	2.46541018
52	Hypoplasia of the thymus (HP:0000778)	2.44406162
53	Amelogenesis imperfecta (HP:0000705)	2.41196449
54	Stage 5 chronic kidney disease (HP:0003774)	2.38909409
55	Abnormality of the parathyroid morphology (HP:0011766)	2.37762389
56	Abnormality of potassium homeostasis (HP:0011042)	2.33281098
57	Absent epiphyses (HP:0010577)	2.27681687
58	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.27681687
59	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.20550234
60	Tubulointerstitial abnormality (HP:0001969)	2.19824829
61	Tetany (HP:0001281)	2.18912561
62	Bronchiectasis (HP:0002110)	2.14733469
63	Renal Fanconi syndrome (HP:0001994)	2.10456182
64	Optic nerve hypoplasia (HP:0000609)	2.10370422
65	Progressive sensorineural hearing impairment (HP:0000408)	2.10338744
66	Abnormality of the costochondral junction (HP:0000919)	2.10218073
67	Truncal obesity (HP:0001956)	2.04074038
68	Decreased central vision (HP:0007663)	2.03285612
69	Abnormality of dental color (HP:0011073)	2.01195958
70	Pancreatic fibrosis (HP:0100732)	2.00703562
71	Tubular atrophy (HP:0000092)	1.99939929
72	Epiphyseal dysplasia (HP:0002656)	1.98721387
73	Occipital encephalocele (HP:0002085)	1.98245984
74	Portal hypertension (HP:0001409)	1.98222614
75	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.96762766
76	Widely patent fontanelles and sutures (HP:0004492)	1.94872033
77	Flattened epiphyses (HP:0003071)	1.91807426
78	Osteomalacia (HP:0002749)	1.88012268
79	Hypophosphatemic rickets (HP:0004912)	1.87761243
80	Chronic bronchitis (HP:0004469)	1.87700092
81	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.83714046
82	Abnormality of femoral epiphyses (HP:0006499)	1.83714046
83	Myokymia (HP:0002411)	1.82291580
84	Type II lissencephaly (HP:0007260)	1.82116606
85	Hyponatremia (HP:0002902)	1.81982805
86	Hypoalphalipoproteinemia (HP:0003233)	1.80356384
87	Pendular nystagmus (HP:0012043)	1.79560473
88	Abnormality of the hepatic vasculature (HP:0006707)	1.78145036
89	Spastic paraparesis (HP:0002313)	1.77655826
90	Intellectual disability, moderate (HP:0002342)	1.77392441
91	Abnormality of chloride homeostasis (HP:0011422)	1.75745881
92	Glycosuria (HP:0003076)	1.75417269
93	Abnormality of urine glucose concentration (HP:0011016)	1.75417269
94	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.75272118
95	Pancreatic cysts (HP:0001737)	1.71649338
96	Abnormality of the femoral head (HP:0003368)	1.71494610
97	Flat capital femoral epiphysis (HP:0003370)	1.71294958
98	Sclerocornea (HP:0000647)	1.71221933
99	Mixed hearing impairment (HP:0000410)	1.70889476
100	Short ribs (HP:0000773)	1.70655073

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.96996399
2	TESK1	5.67524494
3	DDR2	4.94965901
4	MAP4K2	3.39112877
5	INSRR	3.36417271
6	PNCK	3.34100433
7	PLK2	2.97629789
8	STK38	2.88232960
9	MAPK15	2.79669767
10	BRD4	2.49561944
11	CAMK1G	2.25854518
12	STK38L	2.24796234
13	MAP3K9	1.94901461
14	PRKD3	1.94307211
15	WNK1	1.63719693
16	MST1R	1.42738069
17	CDK7	1.35098273
18	PDPK1	1.30414084
19	DYRK1B	1.29347944
20	PDK1	1.21087218
21	WNK4	1.14157136
22	PIK3CG	1.13871494
23	CDK12	1.04111751
24	UHMK1	1.00860604
25	PTK2B	0.95320936
26	MARK1	0.94634097
27	CAMK1D	0.87800566
28	NEK6	0.87004046
29	TNIK	0.86651926
30	SIK2	0.84673417
31	BMPR1B	0.81278215
32	TIE1	0.75924667
33	PRKG1	0.75535198
34	RPS6KA2	0.75532559
35	LATS2	0.73711221
36	KSR2	0.73017778
37	BRAF	0.73003956
38	WNK3	0.68838923
39	MAP3K4	0.67386286
40	PRKAA2	0.66396221
41	RPS6KA1	0.65725174
42	AKT3	0.65246254
43	PRKG2	0.64257783
44	PRKCG	0.62346478
45	CAMK1	0.58851060
46	SGK223	0.57633024
47	SGK494	0.57633024
48	ROCK1	0.56271430
49	MAP2K2	0.56028222
50	STK39	0.55834317
51	CDK3	0.55766495
52	TYRO3	0.55535898
53	ADRBK2	0.52024553
54	DYRK3	0.51883522
55	GSK3B	0.50040019
56	DYRK2	0.49846726
57	CDK1	0.48415596
58	CDK2	0.48274288
59	MAP3K11	0.46449412
60	RPS6KA6	0.45721621
61	LATS1	0.44937539
62	PRKCZ	0.43583620
63	RPS6KC1	0.43006229
64	RPS6KL1	0.43006229
65	MAPK1	0.41904784
66	FRK	0.41101794
67	MAP2K7	0.39011368
68	BRSK2	0.38978636
69	PINK1	0.38092809
70	ARAF	0.37137974
71	CDK4	0.36263190
72	CHEK1	0.36213921
73	MAP3K8	0.36100233
74	SGK1	0.35496397
75	MUSK	0.33461611
76	MAPK8	0.31632229
77	CAMK4	0.31467162
78	OXSR1	0.30885511
79	MKNK2	0.30365950
80	ZAK	0.30127146
81	PRKCB	0.29384590
82	GRK1	0.29326408
83	MAPK14	0.29285405
84	PKN1	0.28967642
85	PRKCE	0.28334081
86	SGK2	0.28023068
87	BRSK1	0.27776986
88	FER	0.26483107
89	NEK2	0.24892298
90	NTRK3	0.24675944
91	MAPK13	0.23847233
92	VRK1	0.23803388
93	NUAK1	0.22372193
94	AKT1	0.19787686
95	MINK1	0.19096947
96	LMTK2	0.18783622
97	MARK2	0.18675143
98	MTOR	0.18609705
99	MAP3K2	0.18443834
100	PRKACA	0.18249389

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	8.01479091
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.27268819
3	Olfactory transduction_Homo sapiens_hsa04740	3.74011288
4	Butanoate metabolism_Homo sapiens_hsa00650	2.95840417
5	Taste transduction_Homo sapiens_hsa04742	2.01552432
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.91410570
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.60124115
8	Phototransduction_Homo sapiens_hsa04744	1.58732602
9	RNA transport_Homo sapiens_hsa03013	1.57972096
10	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.57143165
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.49822560
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.48073599
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.48026902
14	Type II diabetes mellitus_Homo sapiens_hsa04930	1.47695068
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.39657068
16	Fatty acid degradation_Homo sapiens_hsa00071	1.37685075
17	Nicotine addiction_Homo sapiens_hsa05033	1.32717229
18	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.32087033
19	Arginine and proline metabolism_Homo sapiens_hsa00330	1.30229748
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.28837163
21	Basal transcription factors_Homo sapiens_hsa03022	1.25192775
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.23499281
23	Phenylalanine metabolism_Homo sapiens_hsa00360	1.23223235
24	Allograft rejection_Homo sapiens_hsa05330	1.19128495
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17591353
26	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.16455324
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.16159593
28	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.14252399
29	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.13001818
30	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.11398851
31	Morphine addiction_Homo sapiens_hsa05032	1.08583414
32	Salivary secretion_Homo sapiens_hsa04970	1.08400968
33	Protein digestion and absorption_Homo sapiens_hsa04974	1.07941072
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05540897
35	Graft-versus-host disease_Homo sapiens_hsa05332	1.03631036
36	Antigen processing and presentation_Homo sapiens_hsa04612	0.98109568
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97287580
38	Circadian entrainment_Homo sapiens_hsa04713	0.97237030
39	Huntingtons disease_Homo sapiens_hsa05016	0.95401454
40	Fat digestion and absorption_Homo sapiens_hsa04975	0.93307306
41	ABC transporters_Homo sapiens_hsa02010	0.92315099
42	Oocyte meiosis_Homo sapiens_hsa04114	0.92122517
43	cAMP signaling pathway_Homo sapiens_hsa04024	0.89950570
44	Arginine biosynthesis_Homo sapiens_hsa00220	0.88859960
45	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.87762271
46	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.87416477
47	Calcium signaling pathway_Homo sapiens_hsa04020	0.84539986
48	Purine metabolism_Homo sapiens_hsa00230	0.84286137
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.81000464
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.80157778
51	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.78985291
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.78645722
53	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.78035764
54	Endocytosis_Homo sapiens_hsa04144	0.76308035
55	Retinol metabolism_Homo sapiens_hsa00830	0.75555946
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74378459
57	Insulin secretion_Homo sapiens_hsa04911	0.73812657
58	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.72494166
59	Viral myocarditis_Homo sapiens_hsa05416	0.71008210
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68924199
61	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.68062552
62	Propanoate metabolism_Homo sapiens_hsa00640	0.67745702
63	Fanconi anemia pathway_Homo sapiens_hsa03460	0.64195957
64	Tyrosine metabolism_Homo sapiens_hsa00350	0.60530843
65	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.58668914
66	Tight junction_Homo sapiens_hsa04530	0.57758974
67	PPAR signaling pathway_Homo sapiens_hsa03320	0.57418218
68	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.57188641
69	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.57010600
70	Bile secretion_Homo sapiens_hsa04976	0.54642686
71	GABAergic synapse_Homo sapiens_hsa04727	0.54078214
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.53396345
73	Renin-angiotensin system_Homo sapiens_hsa04614	0.51808107
74	Serotonergic synapse_Homo sapiens_hsa04726	0.49554514
75	Cocaine addiction_Homo sapiens_hsa05030	0.48777529
76	Estrogen signaling pathway_Homo sapiens_hsa04915	0.48279790
77	Gastric acid secretion_Homo sapiens_hsa04971	0.48172679
78	Renin secretion_Homo sapiens_hsa04924	0.47838731
79	Cholinergic synapse_Homo sapiens_hsa04725	0.44312836
80	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.43490368
81	MAPK signaling pathway_Homo sapiens_hsa04010	0.43232992
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.42920845
83	Basal cell carcinoma_Homo sapiens_hsa05217	0.41985694
84	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.37469658
85	Pancreatic secretion_Homo sapiens_hsa04972	0.34909552
86	mRNA surveillance pathway_Homo sapiens_hsa03015	0.34645267
87	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.33808023
88	Metabolic pathways_Homo sapiens_hsa01100	0.33719750
89	Peroxisome_Homo sapiens_hsa04146	0.31297078
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.28067265
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.26204220
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.25685553
93	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.24832810
94	Amphetamine addiction_Homo sapiens_hsa05031	0.24574436
95	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.24495371
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.22725091
97	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.22560369
98	Influenza A_Homo sapiens_hsa05164	0.20381125
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.19080489
100	Circadian rhythm_Homo sapiens_hsa04710	0.18443611

GOLGA6L10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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