ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	plasma membrane fusion (GO:0045026)	8.68799471
2	response to pheromone (GO:0019236)	8.16669861
3	spermatid development (GO:0007286)	8.11313769
4	chromosome condensation (GO:0030261)	7.93816947
5	microtubule depolymerization (GO:0007019)	7.91610978
6	DNA packaging (GO:0006323)	7.90377551
7	single strand break repair (GO:0000012)	7.89754903
8	multicellular organism reproduction (GO:0032504)	7.45694733
9	spermatid nucleus differentiation (GO:0007289)	7.39017098
10	sperm-egg recognition (GO:0035036)	7.12975440
11	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.92298327
12	reproduction (GO:0000003)	6.80712754
13	protein polyglutamylation (GO:0018095)	6.74704264
14	calcium ion-dependent exocytosis (GO:0017156)	6.63010013
15	microtubule polymerization or depolymerization (GO:0031109)	6.58425700
16	phosphatidylethanolamine metabolic process (GO:0046337)	6.45151682
17	protein targeting to Golgi (GO:0000042)	6.33687283
18	centriole replication (GO:0007099)	6.20326034
19	establishment of protein localization to Golgi (GO:0072600)	6.11668950
20	rRNA methylation (GO:0031167)	6.11177068
21	regulation of transcription involved in cell fate commitment (GO:0060850)	6.10946779
22	regulation of Rab GTPase activity (GO:0032313)	6.02884607
23	positive regulation of Rab GTPase activity (GO:0032851)	6.02884607
24	negative regulation of inclusion body assembly (GO:0090084)	6.01241733
25	sexual reproduction (GO:0019953)	5.99759031
26	binding of sperm to zona pellucida (GO:0007339)	5.95421023
27	axonemal dynein complex assembly (GO:0070286)	5.95328298
28	microtubule severing (GO:0051013)	5.93560322
29	cell-cell recognition (GO:0009988)	5.92947413
30	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.88851877
31	spermatogenesis (GO:0007283)	5.80522441
32	regulation of cilium movement (GO:0003352)	5.78762581
33	male gamete generation (GO:0048232)	5.78421468
34	gamete generation (GO:0007276)	5.28489257
35	centriole assembly (GO:0098534)	5.25552142
36	rRNA modification (GO:0000154)	5.14709028
37	cilium or flagellum-dependent cell motility (GO:0001539)	5.12226093
38	cellular ketone body metabolic process (GO:0046950)	4.98110956
39	regulation of centriole replication (GO:0046599)	4.93446444
40	single fertilization (GO:0007338)	4.79730966
41	RNA destabilization (GO:0050779)	4.65415416
42	cell wall macromolecule metabolic process (GO:0044036)	4.60218067
43	germ cell development (GO:0007281)	4.50890196
44	protein localization to Golgi apparatus (GO:0034067)	4.50663190
45	Golgi to endosome transport (GO:0006895)	4.49994694
46	musculoskeletal movement (GO:0050881)	4.45597535
47	multicellular organismal movement (GO:0050879)	4.45597535
48	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.39175074
49	ketone body metabolic process (GO:1902224)	4.38744025
50	regulation of inclusion body assembly (GO:0090083)	4.32156766
51	cell wall macromolecule catabolic process (GO:0016998)	4.25889668
52	organic cation transport (GO:0015695)	4.25188250
53	multicellular organismal reproductive process (GO:0048609)	4.23797504
54	peptidyl-threonine dephosphorylation (GO:0035970)	4.20120075
55	motile cilium assembly (GO:0044458)	4.17071886
56	epithelial cilium movement (GO:0003351)	4.07993796
57	response to acidic pH (GO:0010447)	4.04976897
58	fertilization (GO:0009566)	3.99375298
59	chromatin silencing (GO:0006342)	3.96484813
60	seminiferous tubule development (GO:0072520)	3.93380860
61	regulation of microtubule-based movement (GO:0060632)	3.92185903
62	cerebral cortex neuron differentiation (GO:0021895)	3.85593238
63	nucleus organization (GO:0006997)	3.84496751
64	cellular response to pH (GO:0071467)	3.68811729
65	cilium movement (GO:0003341)	3.60748756
66	polyamine biosynthetic process (GO:0006596)	3.56935777
67	regulation of female gonad development (GO:2000194)	3.42749938
68	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.40661695
69	coenzyme catabolic process (GO:0009109)	3.31736025
70	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.29191505
71	membrane protein intracellular domain proteolysis (GO:0031293)	3.23871598
72	microtubule nucleation (GO:0007020)	3.23295072
73	homeostasis of number of cells within a tissue (GO:0048873)	3.13189429
74	regulation of guanylate cyclase activity (GO:0031282)	3.11202442
75	regulation of T-helper 2 cell differentiation (GO:0045628)	3.09524291
76	multicellular organismal development (GO:0007275)	3.09442726
77	positive regulation of guanylate cyclase activity (GO:0031284)	3.05052495
78	protein-DNA complex disassembly (GO:0032986)	3.03207130
79	nucleosome disassembly (GO:0006337)	3.03207130
80	regulation of interleukin-13 production (GO:0032656)	3.02526199
81	male meiosis I (GO:0007141)	2.95206957
82	protein depolymerization (GO:0051261)	2.92571875
83	negative regulation of Rho protein signal transduction (GO:0035024)	2.91419499
84	cell recognition (GO:0008037)	2.88160662
85	centrosome duplication (GO:0051298)	2.87636671
86	regulation of cilium assembly (GO:1902017)	2.87308705
87	spinal cord motor neuron differentiation (GO:0021522)	2.78663825
88	mitotic G1 DNA damage checkpoint (GO:0031571)	2.75786896
89	positive regulation of endothelial cell differentiation (GO:0045603)	2.75490493
90	positive regulation of action potential (GO:0045760)	2.73873422
91	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.73114615
92	glycerol ether metabolic process (GO:0006662)	2.72145425
93	vesicle transport along microtubule (GO:0047496)	2.70232429
94	negative regulation of histone methylation (GO:0031061)	2.68750468
95	mitochondrial fission (GO:0000266)	2.68412482
96	histone H3-K9 demethylation (GO:0033169)	2.68102125
97	sperm motility (GO:0030317)	11.8202363
98	acrosome reaction (GO:0007340)	11.5301843
99	fusion of sperm to egg plasma membrane (GO:0007342)	11.4494736
100	sperm capacitation (GO:0048240)	10.0879205

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.86110552
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.36821591
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.27332389
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.76423217
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.21704587
6	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21704587
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15423691
8	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.13999657
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.10314987
10	CBP_20019798_ChIP-Seq_JUKART_Human	2.10314987
11	DROSHA_22980978_ChIP-Seq_HELA_Human	2.06277765
12	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	2.03183466
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.02359779
14	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.98727469
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98683958
16	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.94417760
17	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.91705275
18	ERA_21632823_ChIP-Seq_H3396_Human	1.87571841
19	NANOG_20526341_ChIP-Seq_ESCs_Human	1.85487811
20	RAC3_21632823_ChIP-Seq_H3396_Human	1.80809280
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79233128
22	CTCF_27219007_Chip-Seq_Bcells_Human	1.79100783
23	BCL6_27268052_Chip-Seq_Bcells_Human	1.78621248
24	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.76060672
25	E2F1_20622854_ChIP-Seq_HELA_Human	1.63159370
26	SMC4_20622854_ChIP-Seq_HELA_Human	1.62673843
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.61667079
28	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.59893568
29	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.59820550
30	P68_20966046_ChIP-Seq_HELA_Human	1.58637538
31	TAF2_19829295_ChIP-Seq_ESCs_Human	1.58291658
32	FUS_26573619_Chip-Seq_HEK293_Human	1.57858283
33	PHF8_20622854_ChIP-Seq_HELA_Human	1.57849206
34	OCT4_20526341_ChIP-Seq_ESCs_Human	1.57276629
35	BCOR_27268052_Chip-Seq_Bcells_Human	1.57138275
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.54119818
37	MYC_19829295_ChIP-Seq_ESCs_Human	1.51582035
38	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.48406686
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48308842
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.48189830
41	CTCF_20526341_ChIP-Seq_ESCs_Human	1.48164784
42	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.48025616
43	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.47838295
44	AR_25329375_ChIP-Seq_VCAP_Human	1.45729642
45	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.45366738
46	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.44561041
47	P300_27268052_Chip-Seq_Bcells_Human	1.43944337
48	ERG_20517297_ChIP-Seq_VCAP_Human	1.43897779
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.41851929
50	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.41538721
51	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.39830449
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37851310
53	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.37239788
54	ZNF274_21170338_ChIP-Seq_K562_Hela	1.37129840
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.36983287
56	TP63_22573176_ChIP-Seq_HFKS_Human	1.32703189
57	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.32500406
58	LXR_22292898_ChIP-Seq_THP-1_Human	1.30446878
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29141077
60	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.27600933
61	P53_21459846_ChIP-Seq_SAOS-2_Human	1.26436044
62	RBPJ_21746931_ChIP-Seq_IB4_Human	1.24330504
63	ETV1_20927104_ChIP-Seq_GIST48_Human	1.23659205
64	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.23604154
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22661803
66	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.22650284
67	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.21386381
68	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.21070096
69	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.19109792
70	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.17909966
71	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17875275
72	CEBPB_22108803_ChIP-Seq_LS180_Human	1.17683911
73	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.17413743
74	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.14849432
75	SMRT_27268052_Chip-Seq_Bcells_Human	1.13361102
76	NFYB_21822215_ChIP-Seq_K562_Human	1.13001577
77	TBL1_22424771_ChIP-Seq_293T_Human	1.09879441
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09338109
79	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.08677852
80	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.08642309
81	P300_19829295_ChIP-Seq_ESCs_Human	1.07732094
82	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.07660710
83	SA1_27219007_Chip-Seq_Bcells_Human	1.06916105
84	TP53_18474530_ChIP-ChIP_U2OS_Human	1.06440016
85	SPI1_20517297_ChIP-Seq_HL60_Human	1.06405151
86	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.04727818
87	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04598594
88	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04598594
89	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.04582465
90	NFYA_21822215_ChIP-Seq_K562_Human	1.04523499
91	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.03990645
92	PHF8_20622853_ChIP-Seq_HELA_Human	1.02774967
93	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.02535152
94	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02530526
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01960964
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01302137
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00796255
98	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.99795140
99	OCT4_19829295_ChIP-Seq_ESCs_Human	0.99659331
100	KLF5_25053715_ChIP-Seq_YYC3_Human	0.98707405

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	5.12288115
2	MP0003878_abnormal_ear_physiology	5.12288115
3	MP0005670_abnormal_white_adipose	4.88930355
4	MP0003698_abnormal_male_reproductive	4.45650009
5	MP0001929_abnormal_gametogenesis	3.87712463
6	MP0001348_abnormal_lacrimal_gland	3.41971239
7	MP0002822_catalepsy	2.95842015
8	MP0002161_abnormal_fertility/fecundity	2.50341490
9	MP0000678_abnormal_parathyroid_gland	2.40166990
10	MP0005451_abnormal_body_composition	2.24364182
11	MP0005410_abnormal_fertilization	11.8444297
12	MP0003718_maternal_effect	1.99447651
13	MP0002210_abnormal_sex_determination	1.88874299
14	MP0005379_endocrine/exocrine_gland_phen	1.81933229
15	MP0003646_muscle_fatigue	1.73205842
16	MP0001485_abnormal_pinna_reflex	1.65328523
17	MP0002132_abnormal_respiratory_system	1.58124130
18	MP0001145_abnormal_male_reproductive	1.49600136
19	MP0003011_delayed_dark_adaptation	1.46235590
20	MP0004859_abnormal_synaptic_plasticity	1.46205143
21	MP0001486_abnormal_startle_reflex	1.46010059
22	MP0000653_abnormal_sex_gland	1.45012133
23	MP0002735_abnormal_chemical_nociception	1.42305335
24	MP0002234_abnormal_pharynx_morphology	1.42092313
25	MP0002282_abnormal_trachea_morphology	1.41094529
26	MP0005423_abnormal_somatic_nervous	1.36785595
27	MP0000534_abnormal_ureter_morphology	1.36270437
28	MP0009053_abnormal_anal_canal	1.30807783
29	MP0002249_abnormal_larynx_morphology	1.30430721
30	MP0002138_abnormal_hepatobiliary_system	1.29207443
31	MP0001968_abnormal_touch/_nociception	1.28304212
32	MP0001765_abnormal_ion_homeostasis	1.27014146
33	MP0001905_abnormal_dopamine_level	1.25340064
34	MP0005310_abnormal_salivary_gland	1.15206561
35	MP0008569_lethality_at_weaning	1.14709926
36	MP0004742_abnormal_vestibular_system	1.14371630
37	MP0001963_abnormal_hearing_physiology	1.07903014
38	MP0000026_abnormal_inner_ear	1.03607130
39	MP0000955_abnormal_spinal_cord	0.99631173
40	MP0002067_abnormal_sensory_capabilities	0.97504304
41	MP0003879_abnormal_hair_cell	0.97310324
42	MP0002557_abnormal_social/conspecific_i	0.91939754
43	MP0005551_abnormal_eye_electrophysiolog	0.91130711
44	MP0001440_abnormal_grooming_behavior	0.89617500
45	MP0002127_abnormal_cardiovascular_syste	0.87063424
46	MP0009745_abnormal_behavioral_response	0.85751024
47	MP0002229_neurodegeneration	0.84939946
48	MP0000049_abnormal_middle_ear	0.84168539
49	MP0005395_other_phenotype	0.83809897
50	MP0002733_abnormal_thermal_nociception	0.81997113
51	MP0002572_abnormal_emotion/affect_behav	0.80674502
52	MP0004510_myositis	0.79798505
53	MP0008877_abnormal_DNA_methylation	0.79399216
54	MP0009115_abnormal_fat_cell	0.75970772
55	MP0005253_abnormal_eye_physiology	0.74619564
56	MP0005248_abnormal_Harderian_gland	0.74343412
57	MP0003283_abnormal_digestive_organ	0.70179836
58	MP0005666_abnormal_adipose_tissue	0.69101645
59	MP0002272_abnormal_nervous_system	0.68489313
60	MP0004085_abnormal_heartbeat	0.67626433
61	MP0002734_abnormal_mechanical_nocicepti	0.66585364
62	MP0003119_abnormal_digestive_system	0.65261937
63	MP0001666_abnormal_nutrient_absorption	0.63930998
64	MP0005636_abnormal_mineral_homeostasis	0.63076802
65	MP0005535_abnormal_body_temperature	0.61732756
66	MP0009046_muscle_twitch	0.60926402
67	MP0005367_renal/urinary_system_phenotyp	0.60752516
68	MP0000516_abnormal_urinary_system	0.60752516
69	MP0005167_abnormal_blood-brain_barrier	0.60608102
70	MP0001970_abnormal_pain_threshold	0.58928719
71	MP0009697_abnormal_copulation	0.58651685
72	MP0000681_abnormal_thyroid_gland	0.57526862
73	MP0008995_early_reproductive_senescence	0.56847883
74	MP0005375_adipose_tissue_phenotype	0.55562515
75	MP0003635_abnormal_synaptic_transmissio	0.55166348
76	MP0005083_abnormal_biliary_tract	0.51116000
77	MP0003699_abnormal_female_reproductive	0.49662535
78	MP0000470_abnormal_stomach_morphology	0.49128032
79	MP0009764_decreased_sensitivity_to	0.48504576
80	MP0000003_abnormal_adipose_tissue	0.48104319
81	MP0004484_altered_response_of	0.46832465
82	MP0002928_abnormal_bile_duct	0.43385600
83	MP0008961_abnormal_basal_metabolism	0.42490941
84	MP0001270_distended_abdomen	0.42445327
85	MP0003077_abnormal_cell_cycle	0.42390645
86	MP0003632_abnormal_nervous_system	0.42126993
87	MP0003252_abnormal_bile_duct	0.41119981
88	MP0006292_abnormal_olfactory_placode	0.40696559
89	MP0003631_nervous_system_phenotype	0.39255230
90	MP0003137_abnormal_impulse_conducting	0.38586379
91	MP0003936_abnormal_reproductive_system	0.37530582
92	MP0001879_abnormal_lymphatic_vessel	0.36808686
93	MP0005391_vision/eye_phenotype	0.36298790
94	MP0000566_synostosis	0.35945811
95	MP0002064_seizures	0.35401059
96	MP0002882_abnormal_neuron_morphology	0.35227274
97	MP0002653_abnormal_ependyma_morphology	0.34680985
98	MP0003091_abnormal_cell_migration	0.34179473
99	MP0000230_abnormal_systemic_arterial	0.33573051
100	MP0002063_abnormal_learning/memory/cond	0.32780015

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.21405268
2	Asymmetric septal hypertrophy (HP:0001670)	5.40047881
3	Bell-shaped thorax (HP:0001591)	5.35304262
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.30602648
5	Absent/shortened dynein arms (HP:0200106)	5.30602648
6	Attenuation of retinal blood vessels (HP:0007843)	5.16323404
7	Bony spicule pigmentary retinopathy (HP:0007737)	5.16182788
8	Hyperkalemia (HP:0002153)	4.57594312
9	Hypoplastic ischia (HP:0003175)	4.48352480
10	Tubulointerstitial nephritis (HP:0001970)	4.47877378
11	Chronic hepatic failure (HP:0100626)	4.44566335
12	Resting tremor (HP:0002322)	4.37969431
13	Abnormal respiratory motile cilium physiology (HP:0012261)	4.29562431
14	Male infertility (HP:0003251)	4.29128515
15	Abnormal ciliary motility (HP:0012262)	4.25703590
16	Abnormal rod and cone electroretinograms (HP:0008323)	4.22638475
17	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.16407500
18	Infertility (HP:0000789)	4.14455487
19	Enlarged epiphyses (HP:0010580)	4.12046463
20	Potter facies (HP:0002009)	4.10642251
21	Facial shape deformation (HP:0011334)	4.10642251
22	Abnormal respiratory epithelium morphology (HP:0012253)	4.04801127
23	Abnormal respiratory motile cilium morphology (HP:0005938)	4.04801127
24	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.98560701
25	Abnormality of the ischium (HP:0003174)	3.96835057
26	Abnormality of macular pigmentation (HP:0008002)	3.77039305
27	Impulsivity (HP:0100710)	3.75080887
28	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.50743173
29	Nasal polyposis (HP:0100582)	3.40956142
30	Postural instability (HP:0002172)	3.35539812
31	Cone-rod dystrophy (HP:0000548)	3.32041220
32	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.30598023
33	Abnormal spermatogenesis (HP:0008669)	3.22129511
34	Hypoplasia of the thymus (HP:0000778)	3.21293233
35	Nephronophthisis (HP:0000090)	3.18438923
36	Progressive cerebellar ataxia (HP:0002073)	3.02929015
37	Abnormal urine output (HP:0012590)	3.00694475
38	Azoospermia (HP:0000027)	2.93915713
39	Epiphyseal dysplasia (HP:0002656)	2.80848564
40	Generalized aminoaciduria (HP:0002909)	2.73064691
41	Abnormality of the nasal mucosa (HP:0000433)	2.72431078
42	Rhinitis (HP:0012384)	2.69768858
43	Hypoalphalipoproteinemia (HP:0003233)	2.68929852
44	Abnormality of the renal medulla (HP:0100957)	2.68186351
45	Abnormality of the costochondral junction (HP:0000919)	2.64036287
46	Abnormality of potassium homeostasis (HP:0011042)	2.63611006
47	Abnormality of renal excretion (HP:0011036)	2.61638593
48	Portal hypertension (HP:0001409)	2.58427298
49	Abnormal drinking behavior (HP:0030082)	2.56950284
50	Polydipsia (HP:0001959)	2.56950284
51	Progressive sensorineural hearing impairment (HP:0000408)	2.55593608
52	Tubulointerstitial abnormality (HP:0001969)	2.51542976
53	Renovascular hypertension (HP:0100817)	2.49789097
54	Truncal obesity (HP:0001956)	2.44419640
55	Widely patent fontanelles and sutures (HP:0004492)	2.43219247
56	Abnormality of dental color (HP:0011073)	2.42775094
57	Renal dysplasia (HP:0000110)	2.42526644
58	Amelogenesis imperfecta (HP:0000705)	2.41215350
59	Absent epiphyses (HP:0010577)	2.40135661
60	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.40135661
61	Polyuria (HP:0000103)	2.40046714
62	Abnormality of the hepatic vasculature (HP:0006707)	2.34713211
63	Menstrual irregularities (HP:0000858)	2.25446507
64	Unilateral renal agenesis (HP:0000122)	2.25002577
65	Stage 5 chronic kidney disease (HP:0003774)	2.23036729
66	Abnormality of the aortic arch (HP:0012303)	2.22312172
67	Abnormality of the pubic bones (HP:0003172)	2.22033875
68	Congenital malformation of the right heart (HP:0011723)	2.19065245
69	Double outlet right ventricle (HP:0001719)	2.19065245
70	Insulin-resistant diabetes mellitus (HP:0000831)	2.17895895
71	Hypophosphatemic rickets (HP:0004912)	2.17329744
72	Recurrent pneumonia (HP:0006532)	2.17302896
73	Occipital encephalocele (HP:0002085)	2.11320793
74	Genetic anticipation (HP:0003743)	2.08460964
75	Protuberant abdomen (HP:0001538)	2.03298333
76	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.02372494
77	Short ribs (HP:0000773)	2.01452794
78	Anterior segment dysgenesis (HP:0007700)	1.99943141
79	Decreased central vision (HP:0007663)	1.98614555
80	Bronchiectasis (HP:0002110)	1.94725866
81	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.94575923
82	Chronic bronchitis (HP:0004469)	1.93878304
83	Intellectual disability, moderate (HP:0002342)	1.93151038
84	Spastic paraparesis (HP:0002313)	1.92192259
85	Hyperuricemia (HP:0002149)	1.91248667
86	Increased purine levels (HP:0004368)	1.91248667
87	Abnormality of femoral epiphyses (HP:0006499)	1.90366795
88	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.90366795
89	Tubular atrophy (HP:0000092)	1.90188282
90	Mixed hearing impairment (HP:0000410)	1.87565432
91	Recurrent corneal erosions (HP:0000495)	1.86449425
92	Congenital sensorineural hearing impairment (HP:0008527)	1.85750644
93	Osteomalacia (HP:0002749)	1.85375719
94	Hyponatremia (HP:0002902)	1.84858325
95	Vertebral clefting (HP:0008428)	1.83299373
96	Abnormality of chloride homeostasis (HP:0011422)	1.81113467
97	Abnormality of the femoral head (HP:0003368)	1.79272387
98	Flattened epiphyses (HP:0003071)	1.78454903
99	Cerebellar dysplasia (HP:0007033)	1.76671451
100	Abnormality of the parathyroid morphology (HP:0011766)	1.75973298

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.23598251
2	TESK1	5.97313077
3	DDR2	5.91482331
4	STK38	3.63320664
5	PNCK	3.37858681
6	PLK2	2.97978222
7	INSRR	2.85134574
8	STK38L	2.64009519
9	MAPK15	2.55387838
10	PRKD3	2.41965657
11	CAMK1G	2.34716705
12	MST1R	2.31760464
13	MAP4K2	2.19479889
14	BRD4	1.97020112
15	PDPK1	1.47214560
16	WNK1	1.45707049
17	DYRK1B	1.38990162
18	PIK3CG	1.35901728
19	PDK1	1.32748662
20	CDK7	1.26612549
21	WNK4	1.22247745
22	PTK2B	1.12601633
23	AKT3	1.04918772
24	SIK2	1.04326902
25	NEK6	1.03842332
26	KSR2	1.01787200
27	CDK12	0.97317361
28	MAP3K9	0.94802908
29	CAMK1D	0.92481291
30	RPS6KA2	0.85004864
31	MAP3K11	0.82862324
32	UHMK1	0.80391226
33	JAK3	0.77498506
34	BRAF	0.76222615
35	PRKG1	0.74977267
36	PRKG2	0.71263677
37	MAP3K2	0.69776423
38	RPS6KA1	0.67946250
39	STK39	0.66298917
40	RIPK4	0.63837517
41	TESK2	0.62027679
42	ROCK1	0.58883143
43	ADRBK2	0.56386641
44	MET	0.54436951
45	MAP2K2	0.52501216
46	OXSR1	0.48868075
47	PRKAA2	0.48455141
48	MUSK	0.48423785
49	RPS6KC1	0.48281574
50	RPS6KL1	0.48281574
51	RPS6KA6	0.47433436
52	CAMK1	0.46718485
53	TYRO3	0.46577217
54	CDK2	0.46210693
55	TNIK	0.43916086
56	SGK494	0.43736539
57	SGK223	0.43736539
58	LATS2	0.43621553
59	GSK3B	0.43519547
60	MAP3K8	0.43423222
61	PRKCG	0.41563359
62	DYRK3	0.39592828
63	CDK3	0.38945005
64	MAPK1	0.37087943
65	MAP3K4	0.36913467
66	NTRK3	0.36040654
67	CDK1	0.35308672
68	CDK4	0.34879551
69	BMPR1B	0.34877804
70	MAPK8	0.34725753
71	MAPK11	0.33577735
72	LATS1	0.33063205
73	PRKCZ	0.32467099
74	MARK1	0.31553875
75	PRKCB	0.31312949
76	RIPK1	0.29309587
77	MAP3K1	0.29218246
78	NEK2	0.29199114
79	MTOR	0.28037838
80	CHEK1	0.27713972
81	SGK1	0.27254151
82	MARK2	0.26819395
83	CAMK4	0.26721469
84	CDK19	0.24560309
85	PRKCE	0.23850619
86	ARAF	0.23132653
87	MAPK14	0.23062324
88	BRSK1	0.22627049
89	ZAK	0.20194262
90	SGK2	0.17995716
91	MAPK10	0.17575949
92	ACVR1B	0.17311562
93	PKN1	0.15771398
94	BRSK2	0.15222591
95	AKT1	0.14351737
96	PRKACB	0.13030497
97	PRKCA	0.11892872
98	PRKAA1	0.10464370
99	PRKACA	0.09772221
100	MINK1	0.09171312

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.73430756
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.46804402
3	Olfactory transduction_Homo sapiens_hsa04740	3.64448302
4	Selenocompound metabolism_Homo sapiens_hsa00450	2.62173320
5	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.34169986
6	Butanoate metabolism_Homo sapiens_hsa00650	2.30706428
7	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.18145177
8	Taste transduction_Homo sapiens_hsa04742	1.84459905
9	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.82879503
10	Fatty acid degradation_Homo sapiens_hsa00071	1.67771272
11	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.64635180
12	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.60216275
13	Type II diabetes mellitus_Homo sapiens_hsa04930	1.57386228
14	Fatty acid metabolism_Homo sapiens_hsa01212	1.46000035
15	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.42049875
16	ABC transporters_Homo sapiens_hsa02010	1.40772908
17	Phototransduction_Homo sapiens_hsa04744	1.39967492
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.34839757
19	Protein digestion and absorption_Homo sapiens_hsa04974	1.31481760
20	Morphine addiction_Homo sapiens_hsa05032	1.30045491
21	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.29814494
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.21807454
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20728203
24	Nicotine addiction_Homo sapiens_hsa05033	1.16486732
25	Phenylalanine metabolism_Homo sapiens_hsa00360	1.15919389
26	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.15211928
27	Calcium signaling pathway_Homo sapiens_hsa04020	1.10953730
28	RNA transport_Homo sapiens_hsa03013	1.10903278
29	Salivary secretion_Homo sapiens_hsa04970	1.06823995
30	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.04346317
31	Allograft rejection_Homo sapiens_hsa05330	1.03429075
32	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.03160330
33	Circadian entrainment_Homo sapiens_hsa04713	1.00833691
34	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00710173
35	Antigen processing and presentation_Homo sapiens_hsa04612	0.99420950
36	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.98825215
37	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.96909683
38	Graft-versus-host disease_Homo sapiens_hsa05332	0.95660008
39	PPAR signaling pathway_Homo sapiens_hsa03320	0.90788013
40	Renin-angiotensin system_Homo sapiens_hsa04614	0.89424746
41	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89026229
42	Endocytosis_Homo sapiens_hsa04144	0.88233845
43	Fat digestion and absorption_Homo sapiens_hsa04975	0.87047456
44	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.86253733
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.85386428
46	cAMP signaling pathway_Homo sapiens_hsa04024	0.84094766
47	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.80380901
48	Estrogen signaling pathway_Homo sapiens_hsa04915	0.80053121
49	Arginine biosynthesis_Homo sapiens_hsa00220	0.79221885
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.77327890
51	Gastric acid secretion_Homo sapiens_hsa04971	0.77065834
52	Bile secretion_Homo sapiens_hsa04976	0.74050875
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.73884246
54	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.73725442
55	Oocyte meiosis_Homo sapiens_hsa04114	0.73640627
56	Cholinergic synapse_Homo sapiens_hsa04725	0.70837609
57	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.69836068
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67818231
59	GABAergic synapse_Homo sapiens_hsa04727	0.66371955
60	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.66235195
61	Viral myocarditis_Homo sapiens_hsa05416	0.65259149
62	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.65174578
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.61673760
64	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.60268848
65	Insulin secretion_Homo sapiens_hsa04911	0.58713735
66	Basal transcription factors_Homo sapiens_hsa03022	0.58117649
67	Serotonergic synapse_Homo sapiens_hsa04726	0.57251874
68	Tight junction_Homo sapiens_hsa04530	0.56254195
69	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.56222463
70	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.54976578
71	Retinol metabolism_Homo sapiens_hsa00830	0.53623857
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51608875
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.51021701
74	Purine metabolism_Homo sapiens_hsa00230	0.50692828
75	Renin secretion_Homo sapiens_hsa04924	0.49962651
76	MAPK signaling pathway_Homo sapiens_hsa04010	0.49616006
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46340529
78	Influenza A_Homo sapiens_hsa05164	0.42936441
79	Caffeine metabolism_Homo sapiens_hsa00232	0.41174973
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.40241796
81	Linoleic acid metabolism_Homo sapiens_hsa00591	0.40154818
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37845186
83	VEGF signaling pathway_Homo sapiens_hsa04370	0.33701283
84	Prolactin signaling pathway_Homo sapiens_hsa04917	0.32321793
85	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.31739544
86	ECM-receptor interaction_Homo sapiens_hsa04512	0.31470337
87	Pancreatic secretion_Homo sapiens_hsa04972	0.29309713
88	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.28996937
89	Acute myeloid leukemia_Homo sapiens_hsa05221	0.27433538
90	Fanconi anemia pathway_Homo sapiens_hsa03460	0.24940343
91	Long-term depression_Homo sapiens_hsa04730	0.22937124
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.21684618
93	Huntingtons disease_Homo sapiens_hsa05016	0.21190056
94	Long-term potentiation_Homo sapiens_hsa04720	0.21041413
95	Cocaine addiction_Homo sapiens_hsa05030	0.19460098
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.18841074
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.16751894
98	Mineral absorption_Homo sapiens_hsa04978	0.15925144
99	Metabolic pathways_Homo sapiens_hsa01100	0.15064100
100	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.14982824

GOLGA6L17P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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