ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	9.29945004
2	chromosome condensation (GO:0030261)	8.67524772
3	DNA packaging (GO:0006323)	8.47554437
4	plasma membrane fusion (GO:0045026)	8.36032989
5	single strand break repair (GO:0000012)	8.33822650
6	spermatid nucleus differentiation (GO:0007289)	8.01636102
7	spermatid development (GO:0007286)	7.98343758
8	microtubule depolymerization (GO:0007019)	7.73621154
9	sperm-egg recognition (GO:0035036)	7.36259193
10	multicellular organism reproduction (GO:0032504)	7.20863231
11	reproduction (GO:0000003)	6.76523291
12	calcium ion-dependent exocytosis (GO:0017156)	6.62705530
13	binding of sperm to zona pellucida (GO:0007339)	6.52565417
14	protein polyglutamylation (GO:0018095)	6.52126660
15	sexual reproduction (GO:0019953)	6.49421544
16	rRNA methylation (GO:0031167)	6.42653309
17	microtubule polymerization or depolymerization (GO:0031109)	6.37586245
18	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.25833475
19	axonemal dynein complex assembly (GO:0070286)	6.15244919
20	negative regulation of inclusion body assembly (GO:0090084)	6.11623224
21	cellular ketone body metabolic process (GO:0046950)	6.10677800
22	cell-cell recognition (GO:0009988)	6.08177275
23	phosphatidylethanolamine metabolic process (GO:0046337)	5.79958956
24	protein targeting to Golgi (GO:0000042)	5.79609478
25	spermatogenesis (GO:0007283)	5.77446571
26	male gamete generation (GO:0048232)	5.75675093
27	establishment of protein localization to Golgi (GO:0072600)	5.70212945
28	microtubule severing (GO:0051013)	5.54793759
29	regulation of Rab GTPase activity (GO:0032313)	5.49606839
30	positive regulation of Rab GTPase activity (GO:0032851)	5.49606839
31	centriole replication (GO:0007099)	5.47927259
32	rRNA modification (GO:0000154)	5.43737213
33	ketone body metabolic process (GO:1902224)	5.40399396
34	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.36332835
35	regulation of cilium movement (GO:0003352)	5.34373101
36	gamete generation (GO:0007276)	5.25494882
37	regulation of transcription involved in cell fate commitment (GO:0060850)	4.96424235
38	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.94448727
39	cilium or flagellum-dependent cell motility (GO:0001539)	4.93638539
40	single fertilization (GO:0007338)	4.69982819
41	chromatin silencing (GO:0006342)	4.69196415
42	centriole assembly (GO:0098534)	4.62924097
43	motile cilium assembly (GO:0044458)	4.56823033
44	germ cell development (GO:0007281)	4.48221969
45	cell wall macromolecule metabolic process (GO:0044036)	4.42710496
46	RNA destabilization (GO:0050779)	4.41409643
47	cell wall macromolecule catabolic process (GO:0016998)	4.32691258
48	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.29265761
49	regulation of inclusion body assembly (GO:0090083)	4.29223866
50	protein localization to Golgi apparatus (GO:0034067)	4.23869515
51	regulation of centriole replication (GO:0046599)	4.23348634
52	multicellular organismal reproductive process (GO:0048609)	4.18708814
53	coenzyme catabolic process (GO:0009109)	4.11919462
54	epithelial cilium movement (GO:0003351)	4.10815215
55	organic cation transport (GO:0015695)	3.99707386
56	peptidyl-threonine dephosphorylation (GO:0035970)	3.86691450
57	fertilization (GO:0009566)	3.84472849
58	multicellular organismal movement (GO:0050879)	3.78916892
59	musculoskeletal movement (GO:0050881)	3.78916892
60	nucleus organization (GO:0006997)	3.71972575
61	negative regulation of Rho protein signal transduction (GO:0035024)	3.70812222
62	cilium movement (GO:0003341)	3.64972286
63	regulation of microtubule-based movement (GO:0060632)	3.62776421
64	seminiferous tubule development (GO:0072520)	3.52737388
65	response to acidic pH (GO:0010447)	3.42610585
66	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.39580970
67	NAD biosynthetic process (GO:0009435)	3.34635681
68	glycerol ether metabolic process (GO:0006662)	3.32450541
69	cerebral cortex neuron differentiation (GO:0021895)	3.31077136
70	cellular response to pH (GO:0071467)	3.26525957
71	polyamine biosynthetic process (GO:0006596)	3.22917183
72	negative regulation of gene expression, epigenetic (GO:0045814)	3.18168510
73	Golgi to endosome transport (GO:0006895)	3.12094216
74	ether metabolic process (GO:0018904)	3.07034362
75	regulation of interleukin-13 production (GO:0032656)	3.01625399
76	cell recognition (GO:0008037)	2.99205808
77	nucleosome disassembly (GO:0006337)	2.97504385
78	protein-DNA complex disassembly (GO:0032986)	2.97504385
79	cranial nerve morphogenesis (GO:0021602)	2.96409772
80	multicellular organismal development (GO:0007275)	2.94636449
81	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.94231972
82	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.94231972
83	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.92581775
84	homeostasis of number of cells within a tissue (GO:0048873)	2.86915577
85	cell differentiation involved in metanephros development (GO:0072202)	2.84286884
86	male meiosis I (GO:0007141)	2.82323421
87	alanine transport (GO:0032328)	2.82299675
88	regulation of T-helper 2 cell differentiation (GO:0045628)	2.81433411
89	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.81188763
90	positive regulation of guanylate cyclase activity (GO:0031284)	2.76485477
91	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.76258108
92	spinal cord motor neuron differentiation (GO:0021522)	2.76171913
93	histone H3-K9 demethylation (GO:0033169)	2.75451110
94	microtubule nucleation (GO:0007020)	2.75002639
95	protein depolymerization (GO:0051261)	2.74528093
96	positive regulation of endothelial cell differentiation (GO:0045603)	2.74144012
97	acrosome reaction (GO:0007340)	11.9587610
98	sperm motility (GO:0030317)	11.4674415
99	fusion of sperm to egg plasma membrane (GO:0007342)	10.9848241
100	response to pheromone (GO:0019236)	10.0219786

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.97416059
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.99441548
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.73721076
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.49970502
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.44827618
6	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.39797029
7	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.39797029
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.20093576
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.19282987
10	CBP_20019798_ChIP-Seq_JUKART_Human	2.19282987
11	DROSHA_22980978_ChIP-Seq_HELA_Human	2.04805493
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.97501968
13	ERA_21632823_ChIP-Seq_H3396_Human	1.94179303
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89992862
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89954584
16	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.87279150
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.86781241
18	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.84772773
19	NANOG_20526341_ChIP-Seq_ESCs_Human	1.82843161
20	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.82673249
21	FUS_26573619_Chip-Seq_HEK293_Human	1.82009614
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.80861713
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.76117041
24	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.74576139
25	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.74092188
26	RAC3_21632823_ChIP-Seq_H3396_Human	1.73076432
27	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.65093552
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60428636
29	AR_25329375_ChIP-Seq_VCAP_Human	1.58112056
30	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.57946896
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.56996076
32	MYC_19829295_ChIP-Seq_ESCs_Human	1.56094642
33	TAF2_19829295_ChIP-Seq_ESCs_Human	1.55949936
34	CTCF_27219007_Chip-Seq_Bcells_Human	1.55219509
35	BCL6_27268052_Chip-Seq_Bcells_Human	1.54657137
36	E2F1_20622854_ChIP-Seq_HELA_Human	1.54495222
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.53646016
38	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.53076789
39	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.52644933
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51554851
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.51198321
42	OCT4_20526341_ChIP-Seq_ESCs_Human	1.50538570
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.45478645
44	AR_21572438_ChIP-Seq_LNCaP_Human	1.44334016
45	P300_19829295_ChIP-Seq_ESCs_Human	1.43342401
46	PHF8_20622854_ChIP-Seq_HELA_Human	1.41938198
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.41052207
48	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.40926253
49	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.39192401
50	CTCF_20526341_ChIP-Seq_ESCs_Human	1.38645108
51	BCOR_27268052_Chip-Seq_Bcells_Human	1.37373874
52	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.34683549
53	SMC4_20622854_ChIP-Seq_HELA_Human	1.34008410
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33742042
55	P300_27268052_Chip-Seq_Bcells_Human	1.33014122
56	VDR_22108803_ChIP-Seq_LS180_Human	1.32693374
57	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.31555528
58	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.31459891
59	P68_20966046_ChIP-Seq_HELA_Human	1.29727531
60	ERG_20517297_ChIP-Seq_VCAP_Human	1.29576573
61	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.28713416
62	TP63_22573176_ChIP-Seq_HFKS_Human	1.26620436
63	P53_21459846_ChIP-Seq_SAOS-2_Human	1.26332012
64	RBPJ_21746931_ChIP-Seq_IB4_Human	1.26034413
65	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.25984022
66	TP53_18474530_ChIP-ChIP_U2OS_Human	1.25828825
67	ETV1_20927104_ChIP-Seq_GIST48_Human	1.24987302
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24903419
69	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.23990146
70	CEBPB_22108803_ChIP-Seq_LS180_Human	1.23184961
71	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23081087
72	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.21283212
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19706836
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19706836
75	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.19254568
76	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.19041534
77	SMRT_27268052_Chip-Seq_Bcells_Human	1.18441420
78	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.18190887
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17875424
80	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.17621669
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17545996
82	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.15966013
83	NFYB_21822215_ChIP-Seq_K562_Human	1.14136082
84	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.13600044
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13242486
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.12993416
87	TBL1_22424771_ChIP-Seq_293T_Human	1.12875565
88	STAT3_23295773_ChIP-Seq_U87_Human	1.11403508
89	SMAD4_21799915_ChIP-Seq_A2780_Human	1.10810836
90	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10519967
91	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.09457812
92	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09392367
93	PHF8_20622853_ChIP-Seq_HELA_Human	1.07626880
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07437375
95	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05747696
96	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.04436243
97	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.01166742
98	NFYA_21822215_ChIP-Seq_K562_Human	1.01163269
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01128667
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.00787904

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	4.93547238
2	MP0005377_hearing/vestibular/ear_phenot	4.93547238
3	MP0005670_abnormal_white_adipose	4.53077832
4	MP0003698_abnormal_male_reproductive	4.30591148
5	MP0001929_abnormal_gametogenesis	3.70182069
6	MP0001348_abnormal_lacrimal_gland	3.52716039
7	MP0000678_abnormal_parathyroid_gland	2.39474255
8	MP0002161_abnormal_fertility/fecundity	2.35824448
9	MP0003646_muscle_fatigue	2.30645437
10	MP0003718_maternal_effect	2.18961002
11	MP0003011_delayed_dark_adaptation	2.08706751
12	MP0005379_endocrine/exocrine_gland_phen	2.00944794
13	MP0005410_abnormal_fertilization	11.7742929
14	MP0002132_abnormal_respiratory_system	1.90709644
15	MP0002822_catalepsy	1.87740250
16	MP0002234_abnormal_pharynx_morphology	1.81811748
17	MP0002210_abnormal_sex_determination	1.68866670
18	MP0005423_abnormal_somatic_nervous	1.65295963
19	MP0001486_abnormal_startle_reflex	1.63982177
20	MP0001485_abnormal_pinna_reflex	1.63061636
21	MP0001968_abnormal_touch/_nociception	1.57213988
22	MP0002735_abnormal_chemical_nociception	1.49265444
23	MP0002249_abnormal_larynx_morphology	1.46335106
24	MP0009053_abnormal_anal_canal	1.41051750
25	MP0002282_abnormal_trachea_morphology	1.37511227
26	MP0001145_abnormal_male_reproductive	1.36741202
27	MP0000653_abnormal_sex_gland	1.32991100
28	MP0002138_abnormal_hepatobiliary_system	1.26905379
29	MP0004742_abnormal_vestibular_system	1.26387184
30	MP0005310_abnormal_salivary_gland	1.25530038
31	MP0001765_abnormal_ion_homeostasis	1.23020766
32	MP0005551_abnormal_eye_electrophysiolog	1.16536066
33	MP0008877_abnormal_DNA_methylation	1.12472959
34	MP0001963_abnormal_hearing_physiology	1.11429277
35	MP0000534_abnormal_ureter_morphology	1.09573240
36	MP0000026_abnormal_inner_ear	1.08575436
37	MP0004859_abnormal_synaptic_plasticity	1.02353964
38	MP0002733_abnormal_thermal_nociception	1.00975814
39	MP0002127_abnormal_cardiovascular_syste	1.00472456
40	MP0005395_other_phenotype	0.99787055
41	MP0005248_abnormal_Harderian_gland	0.99490460
42	MP0001905_abnormal_dopamine_level	0.97364736
43	MP0004510_myositis	0.97320958
44	MP0009745_abnormal_behavioral_response	0.97107986
45	MP0002229_neurodegeneration	0.94584901
46	MP0002067_abnormal_sensory_capabilities	0.89732222
47	MP0002557_abnormal_social/conspecific_i	0.89579802
48	MP0003879_abnormal_hair_cell	0.83640647
49	MP0000955_abnormal_spinal_cord	0.83550471
50	MP0001501_abnormal_sleep_pattern	0.82898325
51	MP0005253_abnormal_eye_physiology	0.82519382
52	MP0002572_abnormal_emotion/affect_behav	0.81596391
53	MP0008569_lethality_at_weaning	0.80209954
54	MP0004085_abnormal_heartbeat	0.78049366
55	MP0000049_abnormal_middle_ear	0.77813442
56	MP0000681_abnormal_thyroid_gland	0.77306591
57	MP0002272_abnormal_nervous_system	0.77151850
58	MP0001970_abnormal_pain_threshold	0.77050058
59	MP0005167_abnormal_blood-brain_barrier	0.76918060
60	MP0006292_abnormal_olfactory_placode	0.74884262
61	MP0000516_abnormal_urinary_system	0.73071270
62	MP0005367_renal/urinary_system_phenotyp	0.73071270
63	MP0003880_abnormal_central_pattern	0.72686871
64	MP0005636_abnormal_mineral_homeostasis	0.68469840
65	MP0005451_abnormal_body_composition	0.67329389
66	MP0001440_abnormal_grooming_behavior	0.65752486
67	MP0005083_abnormal_biliary_tract	0.64479865
68	MP0002928_abnormal_bile_duct	0.64454049
69	MP0009115_abnormal_fat_cell	0.64025627
70	MP0002734_abnormal_mechanical_nocicepti	0.63546229
71	MP0009046_muscle_twitch	0.62991114
72	MP0002653_abnormal_ependyma_morphology	0.61733538
73	MP0004484_altered_response_of	0.61681388
74	MP0003119_abnormal_digestive_system	0.61520961
75	MP0005535_abnormal_body_temperature	0.56299829
76	MP0000470_abnormal_stomach_morphology	0.55762671
77	MP0001666_abnormal_nutrient_absorption	0.55315864
78	MP0005084_abnormal_gallbladder_morpholo	0.54587549
79	MP0003137_abnormal_impulse_conducting	0.54244365
80	MP0003635_abnormal_synaptic_transmissio	0.53979550
81	MP0000569_abnormal_digit_pigmentation	0.52622383
82	MP0008995_early_reproductive_senescence	0.52520474
83	MP0005666_abnormal_adipose_tissue	0.51416859
84	MP0001879_abnormal_lymphatic_vessel	0.51088917
85	MP0009764_decreased_sensitivity_to	0.48430501
86	MP0001984_abnormal_olfaction	0.47624618
87	MP0002064_seizures	0.43331556
88	MP0000230_abnormal_systemic_arterial	0.43315866
89	MP0002736_abnormal_nociception_after	0.43153515
90	MP0005375_adipose_tissue_phenotype	0.42188376
91	MP0000566_synostosis	0.41431322
92	MP0008961_abnormal_basal_metabolism	0.41306089
93	MP0003699_abnormal_female_reproductive	0.40532683
94	MP0003936_abnormal_reproductive_system	0.40362106
95	MP0000613_abnormal_salivary_gland	0.40333739
96	MP0006276_abnormal_autonomic_nervous	0.39532440
97	MP0005645_abnormal_hypothalamus_physiol	0.38959138
98	MP0005647_abnormal_sex_gland	0.38945378
99	MP0003631_nervous_system_phenotype	0.37186150
100	MP0009697_abnormal_copulation	0.36417699

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.35254907
2	Absent/shortened dynein arms (HP:0200106)	5.80822864
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.80822864
4	Attenuation of retinal blood vessels (HP:0007843)	5.80184729
5	Bony spicule pigmentary retinopathy (HP:0007737)	5.49652866
6	Abnormal rod and cone electroretinograms (HP:0008323)	4.76875149
7	Abnormal ciliary motility (HP:0012262)	4.61861106
8	Hypoplastic ischia (HP:0003175)	4.55367524
9	Asymmetric septal hypertrophy (HP:0001670)	4.55024678
10	Bell-shaped thorax (HP:0001591)	4.48311286
11	Abnormal respiratory epithelium morphology (HP:0012253)	4.40969121
12	Abnormal respiratory motile cilium morphology (HP:0005938)	4.40969121
13	Abnormal respiratory motile cilium physiology (HP:0012261)	4.37987507
14	Potter facies (HP:0002009)	4.11061180
15	Facial shape deformation (HP:0011334)	4.11061180
16	Hyperkalemia (HP:0002153)	4.09756314
17	Abnormality of macular pigmentation (HP:0008002)	4.05084075
18	Chronic hepatic failure (HP:0100626)	4.00373010
19	Abnormality of the ischium (HP:0003174)	3.99090481
20	Tubulointerstitial nephritis (HP:0001970)	3.90706117
21	Infertility (HP:0000789)	3.86672797
22	Enlarged epiphyses (HP:0010580)	3.84212903
23	Resting tremor (HP:0002322)	3.81361019
24	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.69257020
25	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.68406312
26	Nasal polyposis (HP:0100582)	3.68256328
27	Male infertility (HP:0003251)	3.62560232
28	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.53838902
29	Azoospermia (HP:0000027)	3.43528697
30	Nephronophthisis (HP:0000090)	3.32201932
31	Impulsivity (HP:0100710)	3.31758009
32	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.30924619
33	Abnormal spermatogenesis (HP:0008669)	3.30582981
34	Postural instability (HP:0002172)	3.00745305
35	Cone-rod dystrophy (HP:0000548)	3.00523536
36	Abnormal urine output (HP:0012590)	2.98380364
37	Progressive cerebellar ataxia (HP:0002073)	2.96220536
38	Abnormality of the nasal mucosa (HP:0000433)	2.89722229
39	Abnormality of the renal medulla (HP:0100957)	2.83372356
40	Hypoplasia of the thymus (HP:0000778)	2.76563294
41	Abnormal drinking behavior (HP:0030082)	2.74138576
42	Polydipsia (HP:0001959)	2.74138576
43	Unilateral renal agenesis (HP:0000122)	2.72564089
44	Congenital malformation of the right heart (HP:0011723)	2.70305218
45	Double outlet right ventricle (HP:0001719)	2.70305218
46	Generalized aminoaciduria (HP:0002909)	2.64622080
47	Renal dysplasia (HP:0000110)	2.64430143
48	Rhinitis (HP:0012384)	2.59958073
49	Abnormality of renal excretion (HP:0011036)	2.56489651
50	Abnormality of potassium homeostasis (HP:0011042)	2.55616903
51	Abnormality of the aortic arch (HP:0012303)	2.54099250
52	Polyuria (HP:0000103)	2.52280427
53	Decreased central vision (HP:0007663)	2.41789714
54	Abnormality of the pubic bones (HP:0003172)	2.41141833
55	Epiphyseal dysplasia (HP:0002656)	2.37323322
56	Stage 5 chronic kidney disease (HP:0003774)	2.36204952
57	Amelogenesis imperfecta (HP:0000705)	2.32242083
58	Abnormality of the costochondral junction (HP:0000919)	2.28895071
59	Absent epiphyses (HP:0010577)	2.22040674
60	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.22040674
61	Truncal obesity (HP:0001956)	2.20666632
62	Abnormality of the parathyroid morphology (HP:0011766)	2.20112373
63	Abnormality of dental color (HP:0011073)	2.18316661
64	Tubulointerstitial abnormality (HP:0001969)	2.17793250
65	Bronchiectasis (HP:0002110)	2.12508025
66	Portal hypertension (HP:0001409)	2.11348575
67	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.08651588
68	Congenital sensorineural hearing impairment (HP:0008527)	2.06226183
69	Progressive sensorineural hearing impairment (HP:0000408)	2.05175892
70	Optic nerve hypoplasia (HP:0000609)	2.03440720
71	Tetany (HP:0001281)	2.03288694
72	Pancreatic fibrosis (HP:0100732)	1.98673290
73	Tubular atrophy (HP:0000092)	1.98007002
74	Hypophosphatemic rickets (HP:0004912)	1.96509696
75	Pendular nystagmus (HP:0012043)	1.95605875
76	Widely patent fontanelles and sutures (HP:0004492)	1.93522357
77	Abnormality of the hepatic vasculature (HP:0006707)	1.92831619
78	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.92457419
79	Abnormality of femoral epiphyses (HP:0006499)	1.92457419
80	Hypoalphalipoproteinemia (HP:0003233)	1.90937436
81	Abnormality of the femoral head (HP:0003368)	1.88462987
82	Bulbous nose (HP:0000414)	1.88153450
83	Occipital encephalocele (HP:0002085)	1.86178990
84	Photophobia (HP:0000613)	1.84117741
85	Genetic anticipation (HP:0003743)	1.83734305
86	Cerebellar dysplasia (HP:0007033)	1.82790105
87	Spastic paraparesis (HP:0002313)	1.80629939
88	Hyponatremia (HP:0002902)	1.80089772
89	Chronic bronchitis (HP:0004469)	1.79873085
90	Pancreatic cysts (HP:0001737)	1.79609896
91	Renovascular hypertension (HP:0100817)	1.78888773
92	Insulin-resistant diabetes mellitus (HP:0000831)	1.78340903
93	Type II lissencephaly (HP:0007260)	1.77518570
94	Flattened epiphyses (HP:0003071)	1.75714087
95	Hypokalemia (HP:0002900)	1.75545415
96	Recurrent corneal erosions (HP:0000495)	1.73121030
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72702122
98	Osteomalacia (HP:0002749)	1.72499518
99	Short ribs (HP:0000773)	1.71327100
100	Mixed hearing impairment (HP:0000410)	1.70317862

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.74546843
2	TESK1	5.86139188
3	DDR2	5.26621257
4	INSRR	4.05918326
5	MAP4K2	3.95917246
6	STK38	3.26377643
7	PLK2	2.91471031
8	PNCK	2.69355874
9	STK38L	2.59950525
10	MAPK15	2.44189435
11	CAMK1G	2.16254982
12	BRD4	2.10447484
13	PRKD3	2.08130900
14	FRK	1.99859650
15	WNK1	1.59643513
16	MST1R	1.55726175
17	PIK3CG	1.41905718
18	PDPK1	1.41868093
19	PDK1	1.33595404
20	PTK2B	1.22803541
21	CDK7	1.21757541
22	DYRK1B	1.11969120
23	BMPR1B	0.98343177
24	CAMK1D	0.96137115
25	WNK4	0.95574486
26	ADRBK2	0.89101444
27	NEK6	0.88676294
28	SIK2	0.85370891
29	MAP3K9	0.84397971
30	STK39	0.83824423
31	KSR2	0.79558991
32	AKT3	0.79063893
33	CDK12	0.76523755
34	PRKAA2	0.75015941
35	PRKG1	0.72919871
36	PINK1	0.70976877
37	UHMK1	0.68865562
38	ZAK	0.63802647
39	PRKG2	0.62850425
40	MUSK	0.62796102
41	MAP2K2	0.62579601
42	RPS6KA2	0.62400385
43	RPS6KA1	0.61316016
44	OXSR1	0.60672890
45	ACVR1B	0.57464827
46	NTRK3	0.56613118
47	MAP3K11	0.55674845
48	MAP3K2	0.55551246
49	CAMK1	0.55006580
50	ROCK1	0.54343985
51	LATS1	0.52090003
52	BRAF	0.51225108
53	LATS2	0.49059083
54	PRKCG	0.48888545
55	RPS6KA6	0.46704815
56	MAP3K4	0.45983390
57	MARK1	0.43904838
58	GSK3B	0.43371263
59	WNK3	0.43106845
60	CDK3	0.42304323
61	MAP3K8	0.41085036
62	CAMK4	0.39695896
63	CDK4	0.38576442
64	CDK2	0.38412310
65	PRKCZ	0.37644472
66	SGK494	0.37429891
67	SGK223	0.37429891
68	MAPK1	0.36523860
69	RPS6KC1	0.36029699
70	RPS6KL1	0.36029699
71	FER	0.35711110
72	CDK1	0.35425518
73	RIPK4	0.35127091
74	PRKCE	0.35065089
75	MAPK8	0.33378048
76	GRK1	0.32244404
77	TLK1	0.32087774
78	NUAK1	0.30531263
79	IKBKB	0.29237172
80	SGK1	0.29165647
81	PRKCB	0.28061347
82	TNIK	0.26547968
83	TNK2	0.25471999
84	GRK7	0.24719454
85	CHEK1	0.24267352
86	BRSK2	0.23565981
87	PKN1	0.23477831
88	TYRO3	0.22308203
89	MAPK11	0.21539426
90	TXK	0.21467301
91	MAPK14	0.21297705
92	TIE1	0.20946809
93	AKT1	0.18752056
94	PRKACA	0.17415304
95	CHUK	0.17249860
96	PRKAA1	0.17034063
97	MTOR	0.16697765
98	CAMK2A	0.16581175
99	DYRK2	0.16250678
100	MET	0.15110836

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.84639897
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.16798262
3	Olfactory transduction_Homo sapiens_hsa04740	3.68120609
4	Butanoate metabolism_Homo sapiens_hsa00650	3.16539525
5	Taste transduction_Homo sapiens_hsa04742	1.99601656
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.96318466
7	Type I diabetes mellitus_Homo sapiens_hsa04940	1.89113655
8	Phototransduction_Homo sapiens_hsa04744	1.84823453
9	Allograft rejection_Homo sapiens_hsa05330	1.81540639
10	Selenocompound metabolism_Homo sapiens_hsa00450	1.79632317
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.78603493
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.76969076
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.71027881
14	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.56192534
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55595123
16	Fatty acid degradation_Homo sapiens_hsa00071	1.49081325
17	Type II diabetes mellitus_Homo sapiens_hsa04930	1.45346459
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.40502201
19	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.38395646
20	Nicotine addiction_Homo sapiens_hsa05033	1.31265903
21	Morphine addiction_Homo sapiens_hsa05032	1.29663936
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.29516523
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.27500710
24	Salivary secretion_Homo sapiens_hsa04970	1.19848467
25	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.16882956
26	ABC transporters_Homo sapiens_hsa02010	1.16807355
27	Arginine and proline metabolism_Homo sapiens_hsa00330	1.13301284
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.12373266
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.03254205
30	Phenylalanine metabolism_Homo sapiens_hsa00360	1.02902630
31	Circadian entrainment_Homo sapiens_hsa04713	1.02669905
32	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.98910493
33	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96097148
34	RNA transport_Homo sapiens_hsa03013	0.95308412
35	Viral myocarditis_Homo sapiens_hsa05416	0.94334358
36	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.93818817
37	Protein digestion and absorption_Homo sapiens_hsa04974	0.93554668
38	Cardiac muscle contraction_Homo sapiens_hsa04260	0.91521881
39	Fat digestion and absorption_Homo sapiens_hsa04975	0.89600191
40	cAMP signaling pathway_Homo sapiens_hsa04024	0.87290624
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85535659
42	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.85276216
43	Nitrogen metabolism_Homo sapiens_hsa00910	0.82429451
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.82008156
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81107256
46	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79226130
47	Endocytosis_Homo sapiens_hsa04144	0.78075397
48	Retinol metabolism_Homo sapiens_hsa00830	0.77407010
49	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.76979292
50	Insulin secretion_Homo sapiens_hsa04911	0.76742001
51	Glutamatergic synapse_Homo sapiens_hsa04724	0.75422020
52	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.74121276
53	PPAR signaling pathway_Homo sapiens_hsa03320	0.70648498
54	Basal transcription factors_Homo sapiens_hsa03022	0.67780047
55	Renin-angiotensin system_Homo sapiens_hsa04614	0.67723889
56	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.67048633
57	Gastric acid secretion_Homo sapiens_hsa04971	0.65199907
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.64552436
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.63368515
60	Arginine biosynthesis_Homo sapiens_hsa00220	0.62937646
61	Purine metabolism_Homo sapiens_hsa00230	0.61715471
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.61479514
63	Serotonergic synapse_Homo sapiens_hsa04726	0.61026620
64	GABAergic synapse_Homo sapiens_hsa04727	0.59927094
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.59447928
66	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.59194473
67	Oocyte meiosis_Homo sapiens_hsa04114	0.59181350
68	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.57475260
69	Renin secretion_Homo sapiens_hsa04924	0.52704438
70	Estrogen signaling pathway_Homo sapiens_hsa04915	0.52454363
71	Cholinergic synapse_Homo sapiens_hsa04725	0.51976314
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.50595246
73	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.50382135
74	Bile secretion_Homo sapiens_hsa04976	0.49913555
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.49901294
76	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.49345528
77	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.46723916
78	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44815929
79	MAPK signaling pathway_Homo sapiens_hsa04010	0.41466040
80	Influenza A_Homo sapiens_hsa05164	0.41008137
81	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.40719916
82	Fanconi anemia pathway_Homo sapiens_hsa03460	0.40187196
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38551393
84	Caffeine metabolism_Homo sapiens_hsa00232	0.37752833
85	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.37641175
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37246098
87	Tight junction_Homo sapiens_hsa04530	0.33195518
88	Huntingtons disease_Homo sapiens_hsa05016	0.30082715
89	Mineral absorption_Homo sapiens_hsa04978	0.29447813
90	Pancreatic secretion_Homo sapiens_hsa04972	0.29432462
91	Peroxisome_Homo sapiens_hsa04146	0.28995157
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.26855696
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.26785126
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25355163
95	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.24705482
96	Metabolic pathways_Homo sapiens_hsa01100	0.23370438
97	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.22782524
98	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.20743259
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.18870067
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.18635328

GOLGA6L22

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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