ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA packaging (GO:0006323)	9.61786956
2	sperm capacitation (GO:0048240)	8.91588542
3	plasma membrane fusion (GO:0045026)	8.87852587
4	microtubule depolymerization (GO:0007019)	8.55814417
5	spermatid nucleus differentiation (GO:0007289)	8.31438175
6	single strand break repair (GO:0000012)	8.28612907
7	sperm-egg recognition (GO:0035036)	7.73442908
8	spermatid development (GO:0007286)	7.61082934
9	binding of sperm to zona pellucida (GO:0007339)	7.50004715
10	sexual reproduction (GO:0019953)	7.20382262
11	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	7.13634093
12	negative regulation of inclusion body assembly (GO:0090084)	7.01176992
13	calcium ion-dependent exocytosis (GO:0017156)	6.72413122
14	multicellular organism reproduction (GO:0032504)	6.66947497
15	microtubule polymerization or depolymerization (GO:0031109)	6.65337883
16	rRNA methylation (GO:0031167)	6.58971503
17	reproduction (GO:0000003)	6.57720699
18	cell-cell recognition (GO:0009988)	6.37560488
19	cellular ketone body metabolic process (GO:0046950)	6.26079037
20	spermatogenesis (GO:0007283)	5.89588544
21	male gamete generation (GO:0048232)	5.87480882
22	protein polyglutamylation (GO:0018095)	5.83790888
23	axonemal dynein complex assembly (GO:0070286)	5.77887879
24	rRNA modification (GO:0000154)	5.54845578
25	ketone body metabolic process (GO:1902224)	5.51862162
26	protein targeting to Golgi (GO:0000042)	5.47405917
27	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.40526877
28	gamete generation (GO:0007276)	5.34922983
29	establishment of protein localization to Golgi (GO:0072600)	5.25414429
30	microtubule severing (GO:0051013)	5.24700980
31	chromatin silencing (GO:0006342)	5.21727880
32	positive regulation of Rab GTPase activity (GO:0032851)	5.10784274
33	regulation of Rab GTPase activity (GO:0032313)	5.10784274
34	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.07004772
35	regulation of inclusion body assembly (GO:0090083)	5.02137583
36	phosphatidylethanolamine metabolic process (GO:0046337)	4.95761651
37	coenzyme catabolic process (GO:0009109)	4.94128213
38	negative regulation of Rho protein signal transduction (GO:0035024)	4.80538471
39	motile cilium assembly (GO:0044458)	4.78024499
40	single fertilization (GO:0007338)	4.53247222
41	centriole replication (GO:0007099)	4.48695147
42	cell wall macromolecule catabolic process (GO:0016998)	4.41945212
43	germ cell development (GO:0007281)	4.31141836
44	glycerol ether metabolic process (GO:0006662)	4.29608416
45	multicellular organismal reproductive process (GO:0048609)	4.27822623
46	regulation of somitogenesis (GO:0014807)	4.21448794
47	regulation of transcription involved in cell fate commitment (GO:0060850)	4.20748949
48	regulation of cilium movement (GO:0003352)	4.16494492
49	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.14023534
50	centriole assembly (GO:0098534)	3.99944910
51	protein localization to Golgi apparatus (GO:0034067)	3.98331746
52	cell wall macromolecule metabolic process (GO:0044036)	3.98272426
53	ether metabolic process (GO:0018904)	3.96171839
54	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.85257229
55	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.85257229
56	RNA destabilization (GO:0050779)	3.84031715
57	nucleus organization (GO:0006997)	3.83008774
58	cilium or flagellum-dependent cell motility (GO:0001539)	3.80670277
59	cell differentiation involved in metanephros development (GO:0072202)	3.71930387
60	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.63897690
61	negative regulation of gene expression, epigenetic (GO:0045814)	3.61461202
62	cranial nerve morphogenesis (GO:0021602)	3.60470644
63	fertilization (GO:0009566)	3.59303491
64	histone H3-K9 demethylation (GO:0033169)	3.55287619
65	regulation of centriole replication (GO:0046599)	3.45851034
66	NAD biosynthetic process (GO:0009435)	3.40745993
67	peptidyl-proline hydroxylation (GO:0019511)	3.39999514
68	tooth mineralization (GO:0034505)	3.37346374
69	epithelial cilium movement (GO:0003351)	3.33146644
70	nucleosome disassembly (GO:0006337)	3.32736232
71	protein-DNA complex disassembly (GO:0032986)	3.32736232
72	glomerular visceral epithelial cell development (GO:0072015)	3.25097435
73	seminiferous tubule development (GO:0072520)	3.24619990
74	regulation of interleukin-13 production (GO:0032656)	3.24090002
75	protein depolymerization (GO:0051261)	3.23733630
76	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.22318212
77	response to acidic pH (GO:0010447)	3.20522464
78	regulation of T-helper 2 cell differentiation (GO:0045628)	3.18944844
79	glomerular epithelial cell development (GO:0072310)	3.16976828
80	DNA conformation change (GO:0071103)	3.11320452
81	organic cation transport (GO:0015695)	3.10205127
82	polyamine biosynthetic process (GO:0006596)	3.10050538
83	multicellular organismal movement (GO:0050879)	3.09448328
84	musculoskeletal movement (GO:0050881)	3.09448328
85	peptidyl-threonine dephosphorylation (GO:0035970)	3.08627806
86	cell recognition (GO:0008037)	3.08152700
87	metanephric mesenchyme development (GO:0072075)	3.05841422
88	opsonization (GO:0008228)	3.05077338
89	cerebral cortex neuron differentiation (GO:0021895)	3.03778846
90	regulation of microtubule-based movement (GO:0060632)	3.03083699
91	actin filament capping (GO:0051693)	3.01134557
92	cofactor catabolic process (GO:0051187)	3.00189494
93	cellular response to pH (GO:0071467)	3.00132506
94	pattern specification involved in kidney development (GO:0061004)	3.00121745
95	cilium movement (GO:0003341)	2.99072276
96	acrosome reaction (GO:0007340)	12.6746773
97	response to pheromone (GO:0019236)	11.7099089
98	fusion of sperm to egg plasma membrane (GO:0007342)	11.6868548
99	sperm motility (GO:0030317)	10.8139242
100	chromosome condensation (GO:0030261)	10.2675225

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.96120906
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	4.08591635
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.60050594
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.80598650
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.35669526
6	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35669526
7	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.33740050
8	ERA_21632823_ChIP-Seq_H3396_Human	2.17368094
9	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	2.04843174
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03631982
11	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.01152475
12	CBP_20019798_ChIP-Seq_JUKART_Human	2.01152475
13	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.98851533
14	RAC3_21632823_ChIP-Seq_H3396_Human	1.95367067
15	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.93531963
16	DROSHA_22980978_ChIP-Seq_HELA_Human	1.92969571
17	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.90542837
18	E2F1_20622854_ChIP-Seq_HELA_Human	1.89119749
19	CTCF_27219007_Chip-Seq_Bcells_Human	1.88915993
20	NANOG_20526341_ChIP-Seq_ESCs_Human	1.88888197
21	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.86651078
22	BCL6_27268052_Chip-Seq_Bcells_Human	1.78731399
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.76143562
24	SMC4_20622854_ChIP-Seq_HELA_Human	1.75083956
25	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.72985526
26	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.71511372
27	TAF2_19829295_ChIP-Seq_ESCs_Human	1.68597518
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67869714
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67099499
30	MYC_19829295_ChIP-Seq_ESCs_Human	1.65224279
31	P68_20966046_ChIP-Seq_HELA_Human	1.65103250
32	LXR_22292898_ChIP-Seq_THP-1_Human	1.64497066
33	PHF8_20622854_ChIP-Seq_HELA_Human	1.63470430
34	CTCF_20526341_ChIP-Seq_ESCs_Human	1.63240535
35	BCOR_27268052_Chip-Seq_Bcells_Human	1.62920126
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61739301
37	TP63_22573176_ChIP-Seq_HFKS_Human	1.60307884
38	FUS_26573619_Chip-Seq_HEK293_Human	1.53767803
39	TP53_18474530_ChIP-ChIP_U2OS_Human	1.52651242
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.52328808
41	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.47864106
42	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.46575552
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.46313031
44	OCT4_20526341_ChIP-Seq_ESCs_Human	1.45083373
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.43587440
46	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.42052600
47	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40277550
48	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.40010287
49	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.38514734
50	RUNX_20019798_ChIP-Seq_JUKART_Human	1.37012933
51	P300_27268052_Chip-Seq_Bcells_Human	1.36856234
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33766173
53	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.31889527
54	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.31112526
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29860926
56	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.26908580
57	P53_21459846_ChIP-Seq_SAOS-2_Human	1.25911636
58	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.25539415
59	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.25411307
60	SA1_27219007_Chip-Seq_Bcells_Human	1.25083585
61	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.24525276
62	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.23887170
63	AR_25329375_ChIP-Seq_VCAP_Human	1.23869515
64	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.23613939
65	EZH2_22144423_ChIP-Seq_EOC_Human	1.22870616
66	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.21724734
67	CEBPB_22108803_ChIP-Seq_LS180_Human	1.20139381
68	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.20073885
69	RBPJ_21746931_ChIP-Seq_IB4_Human	1.18536429
70	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18516489
71	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.18107214
72	TAF15_26573619_Chip-Seq_HEK293_Human	1.17883622
73	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.13936195
74	ETV1_20927104_ChIP-Seq_GIST48_Human	1.12965084
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12746304
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11449780
77	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.10837165
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09705319
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08756491
80	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.08299322
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08130029
82	NFYB_21822215_ChIP-Seq_K562_Human	1.07792604
83	ERG_20517297_ChIP-Seq_VCAP_Human	1.06864776
84	SMRT_27268052_Chip-Seq_Bcells_Human	1.06735209
85	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.05647657
86	TBL1_22424771_ChIP-Seq_293T_Human	1.05091517
87	P300_19829295_ChIP-Seq_ESCs_Human	1.05075989
88	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04406717
89	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.04404831
90	VDR_22108803_ChIP-Seq_LS180_Human	1.01367671
91	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.01327405
92	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.00880200
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98477572
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.98199672
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.97930401
96	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.97571363
97	ZNF274_21170338_ChIP-Seq_K562_Hela	0.95581021
98	STAT1_20625510_ChIP-Seq_HELA_Human	0.95460029
99	OCT4_19829295_ChIP-Seq_ESCs_Human	0.95210057
100	KLF5_25053715_ChIP-Seq_YYC3_Human	0.94638655

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	4.73706392
2	MP0003878_abnormal_ear_physiology	4.73706392
3	MP0003698_abnormal_male_reproductive	4.31462794
4	MP0005670_abnormal_white_adipose	4.16324540
5	MP0001348_abnormal_lacrimal_gland	3.73197740
6	MP0001929_abnormal_gametogenesis	3.60021493
7	MP0000678_abnormal_parathyroid_gland	3.25159225
8	MP0003011_delayed_dark_adaptation	3.08656277
9	MP0002132_abnormal_respiratory_system	2.47102505
10	MP0002161_abnormal_fertility/fecundity	2.40593334
11	MP0003718_maternal_effect	2.25604185
12	MP0002234_abnormal_pharynx_morphology	2.24231169
13	MP0002249_abnormal_larynx_morphology	2.08836523
14	MP0004510_myositis	2.05072724
15	MP0005410_abnormal_fertilization	12.3926724
16	MP0003646_muscle_fatigue	1.78740711
17	MP0005423_abnormal_somatic_nervous	1.74509780
18	MP0005379_endocrine/exocrine_gland_phen	1.64906853
19	MP0009053_abnormal_anal_canal	1.62878216
20	MP0002282_abnormal_trachea_morphology	1.53864689
21	MP0001486_abnormal_startle_reflex	1.41917897
22	MP0002127_abnormal_cardiovascular_syste	1.37766445
23	MP0002210_abnormal_sex_determination	1.36412063
24	MP0004742_abnormal_vestibular_system	1.36073823
25	MP0001765_abnormal_ion_homeostasis	1.32210370
26	MP0000534_abnormal_ureter_morphology	1.31675234
27	MP0005310_abnormal_salivary_gland	1.31457565
28	MP0001485_abnormal_pinna_reflex	1.22976117
29	MP0005248_abnormal_Harderian_gland	1.21586232
30	MP0002735_abnormal_chemical_nociception	1.21192274
31	MP0001968_abnormal_touch/_nociception	1.20528227
32	MP0001145_abnormal_male_reproductive	1.20212401
33	MP0000681_abnormal_thyroid_gland	1.18071621
34	MP0000653_abnormal_sex_gland	1.13667195
35	MP0000049_abnormal_middle_ear	1.12961997
36	MP0000026_abnormal_inner_ear	1.10209006
37	MP0002138_abnormal_hepatobiliary_system	1.08999204
38	MP0001963_abnormal_hearing_physiology	1.07948008
39	MP0005395_other_phenotype	1.07000027
40	MP0004859_abnormal_synaptic_plasticity	0.95612680
41	MP0005367_renal/urinary_system_phenotyp	0.91822106
42	MP0000516_abnormal_urinary_system	0.91822106
43	MP0002733_abnormal_thermal_nociception	0.90311498
44	MP0002653_abnormal_ependyma_morphology	0.90229887
45	MP0001879_abnormal_lymphatic_vessel	0.88592011
46	MP0002229_neurodegeneration	0.87335541
47	MP0003879_abnormal_hair_cell	0.85620674
48	MP0006292_abnormal_olfactory_placode	0.83430467
49	MP0005083_abnormal_biliary_tract	0.83364200
50	MP0000566_synostosis	0.79908191
51	MP0000955_abnormal_spinal_cord	0.79824282
52	MP0005636_abnormal_mineral_homeostasis	0.78666971
53	MP0004085_abnormal_heartbeat	0.76483043
54	MP0008877_abnormal_DNA_methylation	0.73940973
55	MP0004484_altered_response_of	0.71570920
56	MP0005375_adipose_tissue_phenotype	0.65775150
57	MP0001666_abnormal_nutrient_absorption	0.65662066
58	MP0005666_abnormal_adipose_tissue	0.64123387
59	MP0002067_abnormal_sensory_capabilities	0.63845757
60	MP0005623_abnormal_meninges_morphology	0.61895731
61	MP0005167_abnormal_blood-brain_barrier	0.61546054
62	MP0005551_abnormal_eye_electrophysiolog	0.60936409
63	MP0000003_abnormal_adipose_tissue	0.60522707
64	MP0002822_catalepsy	0.58324434
65	MP0001970_abnormal_pain_threshold	0.57954382
66	MP0003119_abnormal_digestive_system	0.57495614
67	MP0008569_lethality_at_weaning	0.55297254
68	MP0000249_abnormal_blood_vessel	0.55290981
69	MP0002557_abnormal_social/conspecific_i	0.55279768
70	MP0003172_abnormal_lysosome_physiology	0.53622628
71	MP0008995_early_reproductive_senescence	0.53081834
72	MP0003942_abnormal_urinary_system	0.51550720
73	MP0000613_abnormal_salivary_gland	0.51199902
74	MP0008961_abnormal_basal_metabolism	0.50929164
75	MP0009115_abnormal_fat_cell	0.49282746
76	MP0003137_abnormal_impulse_conducting	0.47715011
77	MP0002572_abnormal_emotion/affect_behav	0.46260448
78	MP0001501_abnormal_sleep_pattern	0.46145927
79	MP0004233_abnormal_muscle_weight	0.45173253
80	MP0002734_abnormal_mechanical_nocicepti	0.44951125
81	MP0008789_abnormal_olfactory_epithelium	0.44565314
82	MP0003880_abnormal_central_pattern	0.43544298
83	MP0002272_abnormal_nervous_system	0.42974369
84	MP0000470_abnormal_stomach_morphology	0.42540953
85	MP0003936_abnormal_reproductive_system	0.41342514
86	MP0005253_abnormal_eye_physiology	0.39581683
87	MP0000467_abnormal_esophagus_morphology	0.39519174
88	MP0003699_abnormal_female_reproductive	0.38665326
89	MP0000163_abnormal_cartilage_morphology	0.37974845
90	MP0001984_abnormal_olfaction	0.36433244
91	MP0005647_abnormal_sex_gland	0.36424287
92	MP0002928_abnormal_bile_duct	0.36403089
93	MP0001440_abnormal_grooming_behavior	0.34886092
94	MP0005408_hypopigmentation	0.34837517
95	MP0005535_abnormal_body_temperature	0.34433175
96	MP0002115_abnormal_skeleton_extremities	0.34303216
97	MP0000230_abnormal_systemic_arterial	0.34137874
98	MP0004036_abnormal_muscle_relaxation	0.34118578
99	MP0003091_abnormal_cell_migration	0.33161035
100	MP0005166_decreased_susceptibility_to	0.32948444

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	9.19548229
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.47824434
3	Absent/shortened dynein arms (HP:0200106)	5.47824434
4	Attenuation of retinal blood vessels (HP:0007843)	5.35293415
5	Bony spicule pigmentary retinopathy (HP:0007737)	5.27398976
6	Asymmetric septal hypertrophy (HP:0001670)	5.02187683
7	Hypoplastic ischia (HP:0003175)	4.80407249
8	Abnormal rod and cone electroretinograms (HP:0008323)	4.78218303
9	Bell-shaped thorax (HP:0001591)	4.70407021
10	Enlarged epiphyses (HP:0010580)	4.62515578
11	Resting tremor (HP:0002322)	4.48736342
12	Abnormal ciliary motility (HP:0012262)	4.28607347
13	Abnormality of the ischium (HP:0003174)	4.21170171
14	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.15128068
15	Azoospermia (HP:0000027)	4.14819516
16	Abnormal respiratory motile cilium physiology (HP:0012261)	4.10664181
17	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	4.02246224
18	Abnormal respiratory epithelium morphology (HP:0012253)	4.00429652
19	Abnormal respiratory motile cilium morphology (HP:0005938)	4.00429652
20	Facial shape deformation (HP:0011334)	3.97095107
21	Potter facies (HP:0002009)	3.97095107
22	Unilateral renal agenesis (HP:0000122)	3.96881659
23	Nasal polyposis (HP:0100582)	3.91960833
24	Infertility (HP:0000789)	3.90167615
25	Hyperkalemia (HP:0002153)	3.88876239
26	Male infertility (HP:0003251)	3.61156929
27	Abnormality of macular pigmentation (HP:0008002)	3.58294908
28	Abnormal spermatogenesis (HP:0008669)	3.58078258
29	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.54933459
30	Double outlet right ventricle (HP:0001719)	3.54045105
31	Congenital malformation of the right heart (HP:0011723)	3.54045105
32	Abnormality of the aortic arch (HP:0012303)	3.46300002
33	Tubulointerstitial nephritis (HP:0001970)	3.24468553
34	Abnormality of the nasal mucosa (HP:0000433)	3.19395103
35	Renal dysplasia (HP:0000110)	3.14099333
36	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.05322476
37	Impulsivity (HP:0100710)	2.89064254
38	Abnormality of the parathyroid morphology (HP:0011766)	2.81856593
39	Flattened epiphyses (HP:0003071)	2.78159483
40	Cone-rod dystrophy (HP:0000548)	2.77072828
41	Absent epiphyses (HP:0010577)	2.76274421
42	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.76274421
43	Chronic hepatic failure (HP:0100626)	2.75956688
44	Generalized aminoaciduria (HP:0002909)	2.70998484
45	Hypoplasia of the thymus (HP:0000778)	2.68386641
46	Abnormal urine output (HP:0012590)	2.64242370
47	Epiphyseal dysplasia (HP:0002656)	2.63434863
48	Hyperthyroidism (HP:0000836)	2.57175796
49	Postural instability (HP:0002172)	2.55212482
50	Stage 5 chronic kidney disease (HP:0003774)	2.53442756
51	Abnormality of the costochondral junction (HP:0000919)	2.50892043
52	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.43437753
53	Tetany (HP:0001281)	2.41859023
54	Abnormality of the pubic bones (HP:0003172)	2.40886319
55	Ventricular tachycardia (HP:0004756)	2.40547104
56	Abnormality of potassium homeostasis (HP:0011042)	2.39304532
57	Progressive sensorineural hearing impairment (HP:0000408)	2.36989727
58	Abnormality of femoral epiphyses (HP:0006499)	2.29103708
59	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	2.29103708
60	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.28891492
61	Rhinitis (HP:0012384)	2.23868856
62	Abnormality of renal excretion (HP:0011036)	2.23374627
63	Hyponatremia (HP:0002902)	2.18627212
64	Atelectasis (HP:0100750)	2.18409401
65	Flat capital femoral epiphysis (HP:0003370)	2.18166495
66	Abnormality of the femoral head (HP:0003368)	2.17847950
67	Nephronophthisis (HP:0000090)	2.16362490
68	Focal segmental glomerulosclerosis (HP:0000097)	2.15217140
69	Abnormal ventriculo-arterial connection (HP:0011563)	2.14035330
70	Transposition of the great arteries (HP:0001669)	2.14035330
71	Abnormal connection of the cardiac segments (HP:0011545)	2.14035330
72	Hypoparathyroidism (HP:0000829)	2.13534743
73	Hypophosphatemic rickets (HP:0004912)	2.12493422
74	Decreased central vision (HP:0007663)	2.11430932
75	Widely patent fontanelles and sutures (HP:0004492)	2.09233475
76	Polyuria (HP:0000103)	2.06328040
77	Bowel incontinence (HP:0002607)	2.06279996
78	Osteomalacia (HP:0002749)	2.05130127
79	Amelogenesis imperfecta (HP:0000705)	2.04781836
80	Amblyopia (HP:0000646)	2.04523246
81	Polydipsia (HP:0001959)	2.03543793
82	Abnormal drinking behavior (HP:0030082)	2.03543793
83	Vertebral clefting (HP:0008428)	2.03337768
84	Mixed hearing impairment (HP:0000410)	2.02816866
85	Sensory axonal neuropathy (HP:0003390)	2.02237211
86	Progressive cerebellar ataxia (HP:0002073)	1.98625270
87	Spastic paraparesis (HP:0002313)	1.97160474
88	Bradycardia (HP:0001662)	1.96830030
89	Abnormality of dental color (HP:0011073)	1.95397947
90	Truncal obesity (HP:0001956)	1.92492394
91	Abnormal large intestine physiology (HP:0012700)	1.91858419
92	Pendular nystagmus (HP:0012043)	1.89792346
93	Short ribs (HP:0000773)	1.87064452
94	Hypoplastic left heart (HP:0004383)	1.86559976
95	Muscle fiber atrophy (HP:0100295)	1.86075500
96	Bulbous nose (HP:0000414)	1.85850000
97	Protuberant abdomen (HP:0001538)	1.85809563
98	Neoplasm of the heart (HP:0100544)	1.82905352
99	Abnormality of the renal medulla (HP:0100957)	1.81867302
100	Fatigable weakness (HP:0003473)	1.81055825

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.38998728
2	TESK1	6.82968790
3	DDR2	6.05328252
4	MAP4K2	4.93521688
5	INSRR	4.36332580
6	PLK2	2.77519892
7	BRD4	2.62694074
8	STK38	2.54237231
9	MAPK15	2.50818086
10	WNK1	2.45400041
11	MST1R	2.02698000
12	PNCK	1.96407718
13	CAMK1G	1.84459944
14	PRKD3	1.83505765
15	STK38L	1.64250663
16	PDPK1	1.52352066
17	CDK7	1.45653078
18	CDK12	1.43032639
19	PDK1	1.40856926
20	PIK3CG	1.38400616
21	DYRK1B	1.24949739
22	WNK4	1.22981562
23	KSR2	1.22722274
24	MAP3K9	1.22434863
25	PTK2B	1.05519925
26	LATS2	0.90800794
27	UHMK1	0.88984414
28	CAMK1D	0.86727834
29	PRKAA2	0.84855812
30	NEK6	0.81622629
31	RPS6KA2	0.78971881
32	MUSK	0.74062769
33	MAP2K2	0.67734809
34	MAP3K8	0.66550678
35	BRAF	0.65853394
36	CDK4	0.65642418
37	MAP3K11	0.65471494
38	MAP3K2	0.65264378
39	PRKG2	0.64233132
40	RPS6KA1	0.62451406
41	ROCK1	0.61835529
42	MARK2	0.61133074
43	CAMK1	0.58894405
44	PRKG1	0.58595333
45	CAMK4	0.47975172
46	CDK3	0.47558029
47	STK39	0.46963280
48	AKT3	0.46330769
49	ARAF	0.46177728
50	RPS6KC1	0.45257564
51	RPS6KL1	0.45257564
52	GSK3B	0.43386968
53	RPS6KA6	0.41904482
54	MTOR	0.40568568
55	MAPK1	0.40432642
56	CDK1	0.38716058
57	CDK2	0.38615806
58	PRKCZ	0.37803055
59	MET	0.37428832
60	SIK2	0.36836223
61	MARK1	0.34429433
62	LATS1	0.34069729
63	BMPR1B	0.33462693
64	MAPK8	0.33144441
65	PRKCG	0.32759779
66	CHEK1	0.28218969
67	TIE1	0.27877854
68	MAP3K1	0.27355380
69	MAP3K7	0.26805734
70	SGK223	0.24795130
71	SGK494	0.24795130
72	SGK1	0.21911495
73	MAPK14	0.21089356
74	AKT1	0.20675863
75	MAPK10	0.20379057
76	NTRK3	0.19945751
77	BLK	0.17538639
78	MAPK11	0.17511294
79	FRK	0.16565649
80	PRKCB	0.16308477
81	TYRO3	0.15670360
82	ABL2	0.15451651
83	PKN1	0.15361659
84	IKBKB	0.13452431
85	PINK1	0.12910958
86	FER	0.12834814
87	BRSK1	0.11512856
88	MAP3K13	0.11210725
89	MAPK9	0.10890427
90	DYRK3	0.10788823
91	PRKAA1	0.09833591
92	MOS	0.09228652
93	ROCK2	0.08839398
94	PRKACA	0.07659828
95	CHUK	0.06004921
96	DYRK2	0.05524965
97	RPS6KA3	0.05229337
98	CAMK2A	0.05130470
99	TESK2	0.05015212
100	LMTK2	0.04544082

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	8.86786287
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.57950180
3	Olfactory transduction_Homo sapiens_hsa04740	3.61338607
4	Butanoate metabolism_Homo sapiens_hsa00650	2.93313914
5	Allograft rejection_Homo sapiens_hsa05330	2.62671013
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.52630445
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.41939017
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.40809406
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.09005439
10	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.82870406
11	Taste transduction_Homo sapiens_hsa04742	1.81722429
12	Viral myocarditis_Homo sapiens_hsa05416	1.81169737
13	Phenylalanine metabolism_Homo sapiens_hsa00360	1.80321972
14	Arginine and proline metabolism_Homo sapiens_hsa00330	1.78387137
15	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.74086466
16	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.70759685
17	Type II diabetes mellitus_Homo sapiens_hsa04930	1.60678264
18	Fatty acid degradation_Homo sapiens_hsa00071	1.25142137
19	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.24148001
20	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.23489585
21	Endocytosis_Homo sapiens_hsa04144	1.22012869
22	Salivary secretion_Homo sapiens_hsa04970	1.18535592
23	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.17207014
24	Protein digestion and absorption_Homo sapiens_hsa04974	1.14116061
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09656821
26	RNA transport_Homo sapiens_hsa03013	1.08878072
27	Fatty acid metabolism_Homo sapiens_hsa01212	1.04089834
28	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.03788690
29	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.02349581
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.99331094
31	Arginine biosynthesis_Homo sapiens_hsa00220	0.97366379
32	Oocyte meiosis_Homo sapiens_hsa04114	0.89207389
33	Influenza A_Homo sapiens_hsa05164	0.89140001
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84761348
35	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83715430
36	Phototransduction_Homo sapiens_hsa04744	0.82838318
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.81854613
38	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.80452307
39	cAMP signaling pathway_Homo sapiens_hsa04024	0.80384312
40	Fat digestion and absorption_Homo sapiens_hsa04975	0.79363297
41	Tyrosine metabolism_Homo sapiens_hsa00350	0.79086848
42	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.73033740
43	Retinol metabolism_Homo sapiens_hsa00830	0.70384298
44	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.68457791
45	PPAR signaling pathway_Homo sapiens_hsa03320	0.67670868
46	Estrogen signaling pathway_Homo sapiens_hsa04915	0.67370343
47	Calcium signaling pathway_Homo sapiens_hsa04020	0.67067873
48	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.67054464
49	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.66563518
50	Renin-angiotensin system_Homo sapiens_hsa04614	0.66181774
51	Morphine addiction_Homo sapiens_hsa05032	0.60836530
52	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.59765554
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54655714
54	ABC transporters_Homo sapiens_hsa02010	0.54117753
55	Insulin secretion_Homo sapiens_hsa04911	0.53031534
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52389904
57	Circadian entrainment_Homo sapiens_hsa04713	0.51464285
58	Acute myeloid leukemia_Homo sapiens_hsa05221	0.48704609
59	MAPK signaling pathway_Homo sapiens_hsa04010	0.47142573
60	Bile secretion_Homo sapiens_hsa04976	0.46773008
61	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.45394980
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.44939344
63	Purine metabolism_Homo sapiens_hsa00230	0.44896931
64	VEGF signaling pathway_Homo sapiens_hsa04370	0.44003497
65	Viral carcinogenesis_Homo sapiens_hsa05203	0.41558605
66	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.40028811
67	Glutamatergic synapse_Homo sapiens_hsa04724	0.39996620
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.38243618
69	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36933528
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.36818020
71	Gastric acid secretion_Homo sapiens_hsa04971	0.36492570
72	Renin secretion_Homo sapiens_hsa04924	0.36294671
73	Tight junction_Homo sapiens_hsa04530	0.35547518
74	Nicotine addiction_Homo sapiens_hsa05033	0.34942751
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33120651
76	ECM-receptor interaction_Homo sapiens_hsa04512	0.32796606
77	Herpes simplex infection_Homo sapiens_hsa05168	0.31724874
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.30556507
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.30274927
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28187338
81	Basal transcription factors_Homo sapiens_hsa03022	0.27776494
82	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.27324464
83	Cholinergic synapse_Homo sapiens_hsa04725	0.26424984
84	Notch signaling pathway_Homo sapiens_hsa04330	0.25377481
85	Pancreatic secretion_Homo sapiens_hsa04972	0.24938695
86	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24776718
87	Adherens junction_Homo sapiens_hsa04520	0.19844875
88	Serotonergic synapse_Homo sapiens_hsa04726	0.18601239
89	Legionellosis_Homo sapiens_hsa05134	0.18306989
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.18264183
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.17828228
92	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.14506591
93	Toxoplasmosis_Homo sapiens_hsa05145	0.14498733
94	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.14434968
95	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.14367474
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.14237928
97	Nitrogen metabolism_Homo sapiens_hsa00910	0.12981912
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.12818946
99	Prolactin signaling pathway_Homo sapiens_hsa04917	0.12641082
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.11755671

GOLGA6L3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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