ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.56554842
2	acrosome reaction (GO:0007340)	6.45095240
3	sperm motility (GO:0030317)	6.05072173
4	fusion of sperm to egg plasma membrane (GO:0007342)	4.81880589
5	establishment of protein localization to Golgi (GO:0072600)	4.60189922
6	single strand break repair (GO:0000012)	4.59645316
7	regulation of cilium movement (GO:0003352)	4.54924679
8	protein targeting to Golgi (GO:0000042)	4.47473069
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.41351114
10	spermatid development (GO:0007286)	4.39377018
11	protein polyglutamylation (GO:0018095)	4.34794560
12	sperm capacitation (GO:0048240)	4.27825555
13	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.25446614
14	behavioral response to nicotine (GO:0035095)	4.22789030
15	nonmotile primary cilium assembly (GO:0035058)	4.20985973
16	microtubule depolymerization (GO:0007019)	4.07457404
17	epithelial cilium movement (GO:0003351)	4.06121419
18	centriole replication (GO:0007099)	4.03488279
19	calcium ion-dependent exocytosis (GO:0017156)	4.03008632
20	axonemal dynein complex assembly (GO:0070286)	3.97275746
21	plasma membrane fusion (GO:0045026)	3.77725273
22	multicellular organism reproduction (GO:0032504)	3.73598511
23	protein localization to Golgi apparatus (GO:0034067)	3.69057422
24	microtubule polymerization or depolymerization (GO:0031109)	3.68399495
25	microtubule severing (GO:0051013)	3.66275372
26	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.56010359
27	cellular ketone body metabolic process (GO:0046950)	3.55018116
28	positive regulation of gastrulation (GO:2000543)	3.47402548
29	cilium or flagellum-dependent cell motility (GO:0001539)	3.43096362
30	regulation of microtubule-based movement (GO:0060632)	3.41594373
31	cilium movement (GO:0003341)	3.38472068
32	motile cilium assembly (GO:0044458)	3.37738706
33	pyrimidine nucleobase catabolic process (GO:0006208)	3.37442342
34	sperm-egg recognition (GO:0035036)	3.35027133
35	spermatid nucleus differentiation (GO:0007289)	3.33063788
36	regulation of transcription involved in cell fate commitment (GO:0060850)	3.27765484
37	metanephric nephron tubule development (GO:0072234)	3.25278841
38	metanephric tubule development (GO:0072170)	3.25278841
39	regulation of Rab GTPase activity (GO:0032313)	3.10635750
40	positive regulation of Rab GTPase activity (GO:0032851)	3.10635750
41	spermatogenesis (GO:0007283)	3.08458558
42	male gamete generation (GO:0048232)	3.07639180
43	ketone body metabolic process (GO:1902224)	3.06155788
44	reproduction (GO:0000003)	3.04996403
45	DNA packaging (GO:0006323)	3.04126920
46	centriole assembly (GO:0098534)	2.99755870
47	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.98516151
48	chromosome condensation (GO:0030261)	2.93680980
49	somite development (GO:0061053)	2.90542963
50	negative regulation of inclusion body assembly (GO:0090084)	2.87703557
51	metanephric nephron epithelium development (GO:0072243)	2.85688952
52	neuron recognition (GO:0008038)	2.85206598
53	gamete generation (GO:0007276)	2.84725445
54	nephron tubule morphogenesis (GO:0072078)	2.84508780
55	nephron epithelium morphogenesis (GO:0072088)	2.84508780
56	kidney morphogenesis (GO:0060993)	2.83052341
57	spinal cord motor neuron differentiation (GO:0021522)	2.82233908
58	cilium assembly (GO:0042384)	2.82020730
59	presynaptic membrane assembly (GO:0097105)	2.80532665
60	neurotransmitter-gated ion channel clustering (GO:0072578)	2.80468871
61	limb development (GO:0060173)	2.80003755
62	appendage development (GO:0048736)	2.80003755
63	cilium organization (GO:0044782)	2.79110646
64	metanephric epithelium development (GO:0072207)	2.78187944
65	behavioral response to ethanol (GO:0048149)	2.77883981
66	nucleobase catabolic process (GO:0046113)	2.75212689
67	RNA destabilization (GO:0050779)	2.74156776
68	seminiferous tubule development (GO:0072520)	2.73559713
69	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.71943714
70	somite rostral/caudal axis specification (GO:0032525)	2.71065826
71	metanephric mesenchyme development (GO:0072075)	2.70857316
72	phosphatidylethanolamine metabolic process (GO:0046337)	2.66802167
73	positive regulation of action potential (GO:0045760)	2.66791836
74	urinary tract smooth muscle contraction (GO:0014848)	2.66672504
75	negative regulation of Rho protein signal transduction (GO:0035024)	2.66388018
76	neuronal action potential (GO:0019228)	2.66169150
77	presynaptic membrane organization (GO:0097090)	2.66050281
78	membrane depolarization during action potential (GO:0086010)	2.65419735
79	cell-cell recognition (GO:0009988)	2.64733053
80	cranial nerve morphogenesis (GO:0021602)	2.59316976
81	Golgi to endosome transport (GO:0006895)	2.59288775
82	cerebral cortex radially oriented cell migration (GO:0021799)	2.57425926
83	cell differentiation involved in metanephros development (GO:0072202)	2.56805373
84	binding of sperm to zona pellucida (GO:0007339)	2.54942365
85	photoreceptor cell maintenance (GO:0045494)	2.53166283
86	postsynaptic membrane organization (GO:0001941)	2.51301157
87	axonal fasciculation (GO:0007413)	2.49960277
88	dendritic spine morphogenesis (GO:0060997)	2.48696592
89	single fertilization (GO:0007338)	2.46842635
90	short-term memory (GO:0007614)	2.44597915
91	cell differentiation in spinal cord (GO:0021515)	2.40579711
92	alanine transport (GO:0032328)	2.39957357
93	germ cell development (GO:0007281)	2.39646027
94	regulation of action potential (GO:0098900)	2.39638501
95	dopaminergic neuron differentiation (GO:0071542)	2.38244512
96	axoneme assembly (GO:0035082)	2.38167113
97	ventricular system development (GO:0021591)	2.37139536
98	retinal ganglion cell axon guidance (GO:0031290)	2.34109094
99	central nervous system projection neuron axonogenesis (GO:0021952)	2.32466267
100	primary amino compound metabolic process (GO:1901160)	2.31378035

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.67597904
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.87989079
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.79607760
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.69137994
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.57359496
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.45255515
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.41454597
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35343535
9	FUS_26573619_Chip-Seq_HEK293_Human	2.25646612
10	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.20460475
11	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20460475
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.19053029
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15848936
14	VDR_22108803_ChIP-Seq_LS180_Human	2.13495213
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.09920833
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.09869091
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.98013274
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.88882047
19	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.83232609
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.83013223
21	P300_19829295_ChIP-Seq_ESCs_Human	1.77741339
22	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.76102807
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.72799503
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.70479624
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.69892530
26	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.69538569
27	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.69034763
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.69013029
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68002248
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.68002248
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65763356
32	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.64232054
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.62567674
34	DROSHA_22980978_ChIP-Seq_HELA_Human	1.60148998
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57493879
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.57217373
37	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.56584466
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.56066174
39	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.54501011
40	AR_25329375_ChIP-Seq_VCAP_Human	1.53798101
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.53662548
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.51811564
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.51808060
44	EWS_26573619_Chip-Seq_HEK293_Human	1.49638500
45	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.49511980
46	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.49098255
47	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.47654875
48	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.47654875
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.47421967
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46418020
51	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.42129236
52	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.42010747
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41286701
54	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.40236339
55	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.39886975
56	STAT3_23295773_ChIP-Seq_U87_Human	1.39272096
57	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.33429764
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33372082
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32716147
60	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32493878
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31336210
62	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.29684675
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29635316
64	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.29050948
65	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.23874674
66	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23666162
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21534052
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21140672
69	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.21108749
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20820689
71	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.19220904
72	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.19188988
73	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.17717508
74	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.17425934
75	TBL1_22424771_ChIP-Seq_293T_Human	1.17222966
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17162148
77	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16395660
78	TCF4_23295773_ChIP-Seq_U87_Human	1.16163706
79	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.15496229
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14029995
81	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12558482
82	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10185255
83	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07924936
84	BCAT_22108803_ChIP-Seq_LS180_Human	1.05972444
85	TCF4_22108803_ChIP-Seq_LS180_Human	1.05098785
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03640817
87	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03640817
88	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.03594109
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02185540
90	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01775392
91	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.00949414
92	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.00440697
93	ETV1_20927104_ChIP-Seq_GIST48_Human	1.00437602
94	KDM2B_26808549_Chip-Seq_REH_Human	1.00430351
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99853467
96	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99839290
97	NFYB_21822215_ChIP-Seq_K562_Human	0.99260060
98	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99140248
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.98478378
100	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.98351122

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.50780970
2	MP0005377_hearing/vestibular/ear_phenot	2.33239415
3	MP0003878_abnormal_ear_physiology	2.33239415
4	MP0006292_abnormal_olfactory_placode	2.32260243
5	MP0009379_abnormal_foot_pigmentation	2.24395454
6	MP0003698_abnormal_male_reproductive	2.17306030
7	MP0000569_abnormal_digit_pigmentation	2.12046447
8	MP0005670_abnormal_white_adipose	2.10059259
9	MP0005423_abnormal_somatic_nervous	2.07198523
10	MP0000778_abnormal_nervous_system	1.95794444
11	MP0003122_maternal_imprinting	1.91061154
12	MP0005248_abnormal_Harderian_gland	1.83285233
13	MP0001929_abnormal_gametogenesis	1.77504665
14	MP0003011_delayed_dark_adaptation	1.73726450
15	MP0006276_abnormal_autonomic_nervous	1.70397802
16	MP0001485_abnormal_pinna_reflex	1.68444362
17	MP0001486_abnormal_startle_reflex	1.67220877
18	MP0005551_abnormal_eye_electrophysiolog	1.66157947
19	MP0004133_heterotaxia	1.65998232
20	MP0004885_abnormal_endolymph	1.65574241
21	MP0003880_abnormal_central_pattern	1.64887525
22	MP0009745_abnormal_behavioral_response	1.61749336
23	MP0004859_abnormal_synaptic_plasticity	1.59484080
24	MP0005646_abnormal_pituitary_gland	1.59107660
25	MP0002572_abnormal_emotion/affect_behav	1.58917271
26	MP0004142_abnormal_muscle_tone	1.58112994
27	MP0004742_abnormal_vestibular_system	1.56218667
28	MP0001348_abnormal_lacrimal_gland	1.54429273
29	MP0002557_abnormal_social/conspecific_i	1.51149568
30	MP0001968_abnormal_touch/_nociception	1.50599489
31	MP0002272_abnormal_nervous_system	1.48151225
32	MP0009046_muscle_twitch	1.44210572
33	MP0003195_calcinosis	1.43714946
34	MP0002653_abnormal_ependyma_morphology	1.43440545
35	MP0001905_abnormal_dopamine_level	1.42689613
36	MP0003787_abnormal_imprinting	1.41660378
37	MP0000631_abnormal_neuroendocrine_gland	1.41358849
38	MP0001529_abnormal_vocalization	1.40836367
39	MP0001984_abnormal_olfaction	1.40452547
40	MP0001440_abnormal_grooming_behavior	1.38164516
41	MP0008877_abnormal_DNA_methylation	1.37968836
42	MP0002938_white_spotting	1.37498059
43	MP0005379_endocrine/exocrine_gland_phen	1.37448313
44	MP0002735_abnormal_chemical_nociception	1.37060644
45	MP0002067_abnormal_sensory_capabilities	1.36911078
46	MP0003635_abnormal_synaptic_transmissio	1.36437778
47	MP0002928_abnormal_bile_duct	1.34786401
48	MP0000026_abnormal_inner_ear	1.34739454
49	MP0000955_abnormal_spinal_cord	1.34374568
50	MP0003283_abnormal_digestive_organ	1.33564763
51	MP0002063_abnormal_learning/memory/cond	1.29554431
52	MP0003121_genomic_imprinting	1.28627390
53	MP0002734_abnormal_mechanical_nocicepti	1.28582100
54	MP0002822_catalepsy	1.27154426
55	MP0002638_abnormal_pupillary_reflex	1.25218670
56	MP0002210_abnormal_sex_determination	1.25103137
57	MP0002234_abnormal_pharynx_morphology	1.24700927
58	MP0001970_abnormal_pain_threshold	1.24619423
59	MP0002733_abnormal_thermal_nociception	1.24021828
60	MP0010386_abnormal_urinary_bladder	1.23906877
61	MP0000566_synostosis	1.22221678
62	MP0002138_abnormal_hepatobiliary_system	1.21394518
63	MP0003119_abnormal_digestive_system	1.20443927
64	MP0000049_abnormal_middle_ear	1.18531243
65	MP0003136_yellow_coat_color	1.16409094
66	MP0002184_abnormal_innervation	1.14654931
67	MP0005187_abnormal_penis_morphology	1.13428577
68	MP0008995_early_reproductive_senescence	1.13284629
69	MP0005253_abnormal_eye_physiology	1.12300416
70	MP0002161_abnormal_fertility/fecundity	1.12193337
71	MP0002064_seizures	1.09880917
72	MP0002882_abnormal_neuron_morphology	1.08338704
73	MP0002752_abnormal_somatic_nervous	1.07026690
74	MP0001963_abnormal_hearing_physiology	1.02379111
75	MP0001299_abnormal_eye_distance/	1.02110914
76	MP0002102_abnormal_ear_morphology	1.01755861
77	MP0006072_abnormal_retinal_apoptosis	1.01028334
78	MP0001879_abnormal_lymphatic_vessel	0.97989979
79	MP0000653_abnormal_sex_gland	0.97396314
80	MP0005195_abnormal_posterior_eye	0.96622669
81	MP0001145_abnormal_male_reproductive	0.96125152
82	MP0008961_abnormal_basal_metabolism	0.95477754
83	MP0005084_abnormal_gallbladder_morpholo	0.94200146
84	MP0002736_abnormal_nociception_after	0.92332046
85	MP0002837_dystrophic_cardiac_calcinosis	0.89064533
86	MP0004085_abnormal_heartbeat	0.88547861
87	MP0003879_abnormal_hair_cell	0.85600243
88	MP0002282_abnormal_trachea_morphology	0.85360621
89	MP0002249_abnormal_larynx_morphology	0.85279526
90	MP0001188_hyperpigmentation	0.83685715
91	MP0002163_abnormal_gland_morphology	0.83340290
92	MP0002152_abnormal_brain_morphology	0.82266016
93	MP0004145_abnormal_muscle_electrophysio	0.81911628
94	MP0004270_analgesia	0.81671472
95	MP0001501_abnormal_sleep_pattern	0.80305778
96	MP0002229_neurodegeneration	0.79931386
97	MP0001286_abnormal_eye_development	0.79503998
98	MP0008569_lethality_at_weaning	0.79461068
99	MP0005645_abnormal_hypothalamus_physiol	0.79083081
100	MP0001944_abnormal_pancreas_morphology	0.77038900

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	4.69424022
2	Absent/shortened dynein arms (HP:0200106)	4.13199855
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.13199855
4	Pancreatic fibrosis (HP:0100732)	4.01553651
5	Pancreatic cysts (HP:0001737)	3.82907638
6	Nephronophthisis (HP:0000090)	3.64124119
7	True hermaphroditism (HP:0010459)	3.55762615
8	Gait imbalance (HP:0002141)	3.51563945
9	Medial flaring of the eyebrow (HP:0010747)	3.44220791
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.43489784
11	Abnormality of the renal medulla (HP:0100957)	3.31296838
12	Congenital primary aphakia (HP:0007707)	3.19947328
13	Bony spicule pigmentary retinopathy (HP:0007737)	3.19633817
14	Progressive cerebellar ataxia (HP:0002073)	3.18960200
15	Molar tooth sign on MRI (HP:0002419)	3.05564299
16	Abnormality of midbrain morphology (HP:0002418)	3.05564299
17	Abnormal ciliary motility (HP:0012262)	3.02230291
18	Abnormal respiratory epithelium morphology (HP:0012253)	3.01949122
19	Abnormal respiratory motile cilium morphology (HP:0005938)	3.01949122
20	Chronic hepatic failure (HP:0100626)	2.97723132
21	Attenuation of retinal blood vessels (HP:0007843)	2.95309606
22	Cystic liver disease (HP:0006706)	2.91975794
23	Poor coordination (HP:0002370)	2.90525861
24	Nephrogenic diabetes insipidus (HP:0009806)	2.82431156
25	Tubulointerstitial nephritis (HP:0001970)	2.74842584
26	Decreased central vision (HP:0007663)	2.71108027
27	Abnormal respiratory motile cilium physiology (HP:0012261)	2.70955196
28	Genital tract atresia (HP:0001827)	2.67866984
29	Vaginal atresia (HP:0000148)	2.67427349
30	Double outlet right ventricle (HP:0001719)	2.66956513
31	Congenital malformation of the right heart (HP:0011723)	2.66956513
32	Facial shape deformation (HP:0011334)	2.65537790
33	Potter facies (HP:0002009)	2.65537790
34	Hypoplastic ischia (HP:0003175)	2.63247176
35	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.50865205
36	Optic nerve hypoplasia (HP:0000609)	2.48322921
37	Pendular nystagmus (HP:0012043)	2.47081917
38	Congenital sensorineural hearing impairment (HP:0008527)	2.45343135
39	Febrile seizures (HP:0002373)	2.44930694
40	Abnormality of the renal cortex (HP:0011035)	2.44401320
41	Limb dystonia (HP:0002451)	2.41541076
42	Sclerocornea (HP:0000647)	2.39596543
43	Myokymia (HP:0002411)	2.39265295
44	Tubulointerstitial abnormality (HP:0001969)	2.38373179
45	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.29814033
46	Abnormality of macular pigmentation (HP:0008002)	2.29175209
47	Type II lissencephaly (HP:0007260)	2.28842935
48	Anencephaly (HP:0002323)	2.28767645
49	Polydipsia (HP:0001959)	2.27827730
50	Abnormal drinking behavior (HP:0030082)	2.27827730
51	Abnormality of the ischium (HP:0003174)	2.23788728
52	Congenital hepatic fibrosis (HP:0002612)	2.18072953
53	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.16133949
54	Polyphagia (HP:0002591)	2.14690512
55	Drooling (HP:0002307)	2.12962074
56	Azoospermia (HP:0000027)	2.10199722
57	Aplasia/Hypoplasia of the lens (HP:0008063)	2.09391088
58	Specific learning disability (HP:0001328)	2.08488627
59	Tubular atrophy (HP:0000092)	2.06677017
60	Infertility (HP:0000789)	1.99503789
61	Polyuria (HP:0000103)	1.99127954
62	Abnormal urine output (HP:0012590)	1.98816466
63	Enlarged epiphyses (HP:0010580)	1.97196448
64	Tubulointerstitial fibrosis (HP:0005576)	1.96895586
65	Male pseudohermaphroditism (HP:0000037)	1.96712576
66	Bulbous nose (HP:0000414)	1.96405911
67	Congenital stationary night blindness (HP:0007642)	1.96132540
68	Renal dysplasia (HP:0000110)	1.96024100
69	Methylmalonic acidemia (HP:0002912)	1.92561857
70	Postaxial foot polydactyly (HP:0001830)	1.88843096
71	Increased corneal curvature (HP:0100692)	1.87952883
72	Keratoconus (HP:0000563)	1.87952883
73	Excessive salivation (HP:0003781)	1.87904273
74	Broad-based gait (HP:0002136)	1.86917290
75	Abnormality of the aortic arch (HP:0012303)	1.84202997
76	Pachygyria (HP:0001302)	1.82618169
77	Impulsivity (HP:0100710)	1.81918762
78	Abnormality of renal excretion (HP:0011036)	1.80821283
79	Stage 5 chronic kidney disease (HP:0003774)	1.79824703
80	Broad foot (HP:0001769)	1.77767309
81	Genetic anticipation (HP:0003743)	1.76781470
82	Atonic seizures (HP:0010819)	1.76599823
83	Hyperventilation (HP:0002883)	1.75895295
84	Prominent nasal bridge (HP:0000426)	1.74942023
85	Hyperkalemia (HP:0002153)	1.73833617
86	Postaxial hand polydactyly (HP:0001162)	1.73126481
87	Exotropia (HP:0000577)	1.72896548
88	Dialeptic seizures (HP:0011146)	1.72806055
89	Focal seizures (HP:0007359)	1.72604573
90	Hemiparesis (HP:0001269)	1.71815077
91	Abnormality of the nasal septum (HP:0000419)	1.71762874
92	Retinal dysplasia (HP:0007973)	1.71184018
93	Abnormal number of incisors (HP:0011064)	1.66966493
94	Bell-shaped thorax (HP:0001591)	1.64313151
95	Abnormality of chloride homeostasis (HP:0011422)	1.64216615
96	Occipital encephalocele (HP:0002085)	1.64140166
97	Intellectual disability, moderate (HP:0002342)	1.64024001
98	Oligodactyly (hands) (HP:0001180)	1.63922293
99	Shawl scrotum (HP:0000049)	1.63233518
100	Renal Fanconi syndrome (HP:0001994)	1.62158092

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	3.84900557
2	PNCK	3.51432116
3	MARK1	3.39291245
4	FRK	3.35926153
5	CASK	2.80504270
6	DDR2	2.75974397
7	BMPR1B	2.73558077
8	TNIK	2.68506769
9	MAPK15	2.48361860
10	INSRR	2.43872637
11	WNK3	2.38329235
12	NTRK3	2.19278597
13	MAP3K4	2.08816409
14	ADRBK2	1.95693226
15	TIE1	1.88970093
16	MAPK13	1.82265363
17	DYRK2	1.80809070
18	MAP4K2	1.68898089
19	PINK1	1.62053547
20	CAMK1G	1.46020357
21	PLK2	1.45039477
22	NTRK2	1.45001732
23	TYRO3	1.43590506
24	SIK2	1.42985676
25	WNK4	1.39771133
26	MAP2K7	1.34851075
27	EPHB2	1.32878439
28	BRD4	1.26130368
29	DYRK3	1.17111222
30	PRKCG	1.16382385
31	DYRK1B	1.14052205
32	FGFR2	1.09313816
33	PHKG2	1.09199813
34	PHKG1	1.09199813
35	PAK3	1.08315483
36	UHMK1	1.07505813
37	GRK1	1.07392556
38	CDK3	1.04116425
39	MKNK2	0.99409169
40	ACVR1B	0.98432636
41	CDK19	0.96958469
42	PRKD3	0.92603512
43	MAP2K4	0.90627757
44	NME1	0.90271701
45	TESK1	0.89134285
46	WNK1	0.88141098
47	LMTK2	0.87699372
48	CAMK1	0.83267344
49	NEK2	0.82241494
50	TAOK3	0.79449125
51	PIK3CA	0.76784585
52	PRKCE	0.75818656
53	SGK223	0.75013590
54	SGK494	0.75013590
55	EPHA4	0.72745448
56	TGFBR1	0.72160364
57	AKT3	0.71372103
58	NUAK1	0.71068365
59	MINK1	0.70673655
60	PRKG1	0.69305480
61	SGK1	0.68653940
62	STK38L	0.68274344
63	DYRK1A	0.63855864
64	STK38	0.63814356
65	RPS6KA4	0.63786960
66	SGK2	0.63495268
67	BCR	0.60482437
68	MAP3K6	0.60282173
69	CAMK1D	0.58666405
70	PKN1	0.58406946
71	ADRBK1	0.57989079
72	PRKAA2	0.57661217
73	CAMK2A	0.57251252
74	MAP3K9	0.57132572
75	PRKG2	0.55370960
76	TRPM7	0.55358750
77	PRKACB	0.55296862
78	PRKAA1	0.54608344
79	PASK	0.54513196
80	CSNK1G2	0.53093161
81	STK11	0.51190352
82	PRKCZ	0.45384031
83	RPS6KA6	0.45125654
84	PRKACA	0.44444750
85	DMPK	0.40642773
86	RPS6KA2	0.39007918
87	CSNK1E	0.38817562
88	CSNK1G1	0.37341319
89	GSK3B	0.37155141
90	ERBB2	0.36445236
91	BCKDK	0.34704044
92	CAMK4	0.33785068
93	PIK3CG	0.33518723
94	ZAK	0.33144522
95	CDK5	0.33039241
96	CHUK	0.32219120
97	ERBB3	0.30542192
98	RPS6KL1	0.30229138
99	RPS6KC1	0.30229138
100	RPS6KA3	0.29675920

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.39268738
2	Nicotine addiction_Homo sapiens_hsa05033	2.87439870
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.57803881
4	Butanoate metabolism_Homo sapiens_hsa00650	2.38637049
5	Taste transduction_Homo sapiens_hsa04742	2.11840550
6	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.09919072
7	Olfactory transduction_Homo sapiens_hsa04740	2.09563516
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.05591136
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.96715219
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85835620
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.83489377
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.82380450
13	Phototransduction_Homo sapiens_hsa04744	1.72309989
14	Glutamatergic synapse_Homo sapiens_hsa04724	1.66460430
15	Insulin secretion_Homo sapiens_hsa04911	1.65647148
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.64564495
17	Morphine addiction_Homo sapiens_hsa05032	1.64326573
18	Cocaine addiction_Homo sapiens_hsa05030	1.57171943
19	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.57077275
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.56269362
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51340942
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51266366
23	GABAergic synapse_Homo sapiens_hsa04727	1.47283505
24	Circadian entrainment_Homo sapiens_hsa04713	1.44824420
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34119032
26	Caffeine metabolism_Homo sapiens_hsa00232	1.33944257
27	Propanoate metabolism_Homo sapiens_hsa00640	1.33202001
28	Serotonergic synapse_Homo sapiens_hsa04726	1.31810801
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.29943664
30	ABC transporters_Homo sapiens_hsa02010	1.26701992
31	Basal cell carcinoma_Homo sapiens_hsa05217	1.24948977
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.24843716
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.21582101
34	Basal transcription factors_Homo sapiens_hsa03022	1.20043383
35	Type II diabetes mellitus_Homo sapiens_hsa04930	1.19544746
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13101460
37	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.07256482
38	Dopaminergic synapse_Homo sapiens_hsa04728	1.06721791
39	Ribosome_Homo sapiens_hsa03010	1.05794040
40	Huntingtons disease_Homo sapiens_hsa05016	1.03333979
41	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.02272101
42	Cholinergic synapse_Homo sapiens_hsa04725	1.01944128
43	cAMP signaling pathway_Homo sapiens_hsa04024	1.00805219
44	Retinol metabolism_Homo sapiens_hsa00830	1.00768615
45	Circadian rhythm_Homo sapiens_hsa04710	0.99414272
46	Parkinsons disease_Homo sapiens_hsa05012	0.98683149
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96398897
48	Amphetamine addiction_Homo sapiens_hsa05031	0.93300899
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92748491
50	Salivary secretion_Homo sapiens_hsa04970	0.92296940
51	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.92290073
52	Calcium signaling pathway_Homo sapiens_hsa04020	0.92087594
53	Fatty acid degradation_Homo sapiens_hsa00071	0.86770383
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85856740
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83245661
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80962673
57	Axon guidance_Homo sapiens_hsa04360	0.80446893
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.80445849
59	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.80228153
60	Renin secretion_Homo sapiens_hsa04924	0.77347638
61	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.77075383
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.77047715
63	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.75673093
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75471643
65	Protein digestion and absorption_Homo sapiens_hsa04974	0.72470328
66	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.69276910
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67922824
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.66620592
69	Bile secretion_Homo sapiens_hsa04976	0.65714653
70	Long-term depression_Homo sapiens_hsa04730	0.65681492
71	Regulation of autophagy_Homo sapiens_hsa04140	0.65247033
72	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.63677158
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62193374
74	Gastric acid secretion_Homo sapiens_hsa04971	0.62155846
75	Peroxisome_Homo sapiens_hsa04146	0.61405714
76	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.60945571
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.58416062
78	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.57201900
79	Pancreatic secretion_Homo sapiens_hsa04972	0.57131441
80	MAPK signaling pathway_Homo sapiens_hsa04010	0.55970839
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55634756
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55397525
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.54389958
84	Alzheimers disease_Homo sapiens_hsa05010	0.51167352
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49046319
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.48930596
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.47765780
88	Protein export_Homo sapiens_hsa03060	0.46599910
89	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.43448305
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.41842936
91	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.41738003
92	Fanconi anemia pathway_Homo sapiens_hsa03460	0.41667259
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41005678
94	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.40945140
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40664195
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.40008716
97	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39392093
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.38090295
99	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.37893317
100	Mineral absorption_Homo sapiens_hsa04978	0.35355996

GOLGA6L4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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