ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	9.62827181
2	sperm capacitation (GO:0048240)	9.16297235
3	chromosome condensation (GO:0030261)	8.74618019
4	single strand break repair (GO:0000012)	8.69886944
5	DNA packaging (GO:0006323)	8.57377860
6	spermatid nucleus differentiation (GO:0007289)	8.07873364
7	plasma membrane fusion (GO:0045026)	7.61490337
8	spermatid development (GO:0007286)	7.47007949
9	microtubule depolymerization (GO:0007019)	7.08607946
10	sperm-egg recognition (GO:0035036)	6.80847207
11	protein targeting to Golgi (GO:0000042)	6.75945909
12	sexual reproduction (GO:0019953)	6.70725582
13	establishment of protein localization to Golgi (GO:0072600)	6.49332297
14	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.39874796
15	multicellular organism reproduction (GO:0032504)	6.38715292
16	protein polyglutamylation (GO:0018095)	6.27781314
17	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.24213121
18	reproduction (GO:0000003)	6.24036416
19	binding of sperm to zona pellucida (GO:0007339)	6.13508963
20	calcium ion-dependent exocytosis (GO:0017156)	6.07789782
21	microtubule polymerization or depolymerization (GO:0031109)	5.89659076
22	rRNA methylation (GO:0031167)	5.82861301
23	axonemal dynein complex assembly (GO:0070286)	5.79182595
24	phosphatidylethanolamine metabolic process (GO:0046337)	5.75814156
25	negative regulation of inclusion body assembly (GO:0090084)	5.66947988
26	cell-cell recognition (GO:0009988)	5.58299265
27	positive regulation of Rab GTPase activity (GO:0032851)	5.54277668
28	regulation of Rab GTPase activity (GO:0032313)	5.54277668
29	spermatogenesis (GO:0007283)	5.47623887
30	male gamete generation (GO:0048232)	5.45855290
31	centriole replication (GO:0007099)	5.43515399
32	microtubule severing (GO:0051013)	5.31154169
33	cellular ketone body metabolic process (GO:0046950)	5.29383511
34	regulation of transcription involved in cell fate commitment (GO:0060850)	5.15263030
35	regulation of cilium movement (GO:0003352)	5.02760606
36	gamete generation (GO:0007276)	4.98885270
37	protein localization to Golgi apparatus (GO:0034067)	4.92472764
38	chromatin silencing (GO:0006342)	4.84076365
39	cell wall macromolecule catabolic process (GO:0016998)	4.79933872
40	cell wall macromolecule metabolic process (GO:0044036)	4.76995676
41	rRNA modification (GO:0000154)	4.72231663
42	ketone body metabolic process (GO:1902224)	4.63348460
43	centriole assembly (GO:0098534)	4.51437583
44	cilium or flagellum-dependent cell motility (GO:0001539)	4.42173787
45	single fertilization (GO:0007338)	4.41912314
46	motile cilium assembly (GO:0044458)	4.31048113
47	germ cell development (GO:0007281)	4.27055288
48	regulation of centriole replication (GO:0046599)	4.21362379
49	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.17794444
50	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.16108701
51	regulation of inclusion body assembly (GO:0090083)	4.13582465
52	RNA destabilization (GO:0050779)	4.12171392
53	nucleus organization (GO:0006997)	4.03105671
54	multicellular organismal reproductive process (GO:0048609)	4.00423957
55	epithelial cilium movement (GO:0003351)	3.94294765
56	coenzyme catabolic process (GO:0009109)	3.80362532
57	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.70015702
58	protein-DNA complex disassembly (GO:0032986)	3.65551569
59	nucleosome disassembly (GO:0006337)	3.65551569
60	fertilization (GO:0009566)	3.65382802
61	negative regulation of Rho protein signal transduction (GO:0035024)	3.64329785
62	histone H3-K9 demethylation (GO:0033169)	3.61819877
63	cerebral cortex neuron differentiation (GO:0021895)	3.55350722
64	Golgi to endosome transport (GO:0006895)	3.48944853
65	seminiferous tubule development (GO:0072520)	3.48724380
66	organic cation transport (GO:0015695)	3.44749222
67	musculoskeletal movement (GO:0050881)	3.43726014
68	multicellular organismal movement (GO:0050879)	3.43726014
69	regulation of microtubule-based movement (GO:0060632)	3.43367819
70	cilium movement (GO:0003341)	3.39714231
71	peptidyl-threonine dephosphorylation (GO:0035970)	3.36262678
72	negative regulation of gene expression, epigenetic (GO:0045814)	3.35409694
73	regulation of ARF GTPase activity (GO:0032312)	3.25406474
74	cranial nerve morphogenesis (GO:0021602)	3.25344239
75	glycerol ether metabolic process (GO:0006662)	3.19439076
76	response to acidic pH (GO:0010447)	3.19389395
77	regulation of somitogenesis (GO:0014807)	3.15674069
78	negative regulation of histone methylation (GO:0031061)	3.09387260
79	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.06097629
80	cellular response to pH (GO:0071467)	3.04890917
81	microtubule nucleation (GO:0007020)	3.02481712
82	cell differentiation involved in metanephros development (GO:0072202)	2.99438848
83	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.97874567
84	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.97874567
85	ether metabolic process (GO:0018904)	2.93106705
86	regulation of T-helper 2 cell differentiation (GO:0045628)	2.89961511
87	regulation of interleukin-13 production (GO:0032656)	2.89810192
88	receptor recycling (GO:0001881)	2.88151915
89	regulation of histone H3-K27 methylation (GO:0061085)	2.85463231
90	pattern specification involved in kidney development (GO:0061004)	2.83995644
91	coronary vasculature morphogenesis (GO:0060977)	2.82337902
92	multicellular organismal development (GO:0007275)	2.82160090
93	DNA conformation change (GO:0071103)	2.81929096
94	homeostasis of number of cells within a tissue (GO:0048873)	2.80465785
95	cell recognition (GO:0008037)	2.79932550
96	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.79606266
97	NAD biosynthetic process (GO:0009435)	2.74707972
98	acrosome reaction (GO:0007340)	11.4216161
99	sperm motility (GO:0030317)	10.8670033
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.0386013

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.13552281
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.23573253
3	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.40710450
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.40710450
5	DROSHA_22980978_ChIP-Seq_HELA_Human	2.34522532
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29167210
7	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.21789134
8	CBP_20019798_ChIP-Seq_JUKART_Human	2.21789134
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.16942181
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09661629
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.06773199
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.00684796
13	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.96065017
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.93844196
15	FUS_26573619_Chip-Seq_HEK293_Human	1.87072461
16	ERA_21632823_ChIP-Seq_H3396_Human	1.85824900
17	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.80664988
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.73711427
19	AR_21572438_ChIP-Seq_LNCaP_Human	1.73486798
20	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.70863680
21	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.68490182
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67077069
23	CTCF_27219007_Chip-Seq_Bcells_Human	1.63896730
24	NANOG_20526341_ChIP-Seq_ESCs_Human	1.63845933
25	RAC3_21632823_ChIP-Seq_H3396_Human	1.63350530
26	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.62431300
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61916681
28	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.59778815
29	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.57460584
30	SMC4_20622854_ChIP-Seq_HELA_Human	1.53732494
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51409675
32	AR_25329375_ChIP-Seq_VCAP_Human	1.51281864
33	E2F1_20622854_ChIP-Seq_HELA_Human	1.50868307
34	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.49982022
35	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.46675114
36	BCL6_27268052_Chip-Seq_Bcells_Human	1.45193840
37	ZNF274_21170338_ChIP-Seq_K562_Hela	1.42584466
38	PHF8_20622854_ChIP-Seq_HELA_Human	1.42558072
39	MYC_19829295_ChIP-Seq_ESCs_Human	1.42532309
40	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.41641637
41	OCT4_20526341_ChIP-Seq_ESCs_Human	1.40987671
42	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40644079
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.38311107
44	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.37157945
45	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.36690078
46	TAF2_19829295_ChIP-Seq_ESCs_Human	1.36096201
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35496766
48	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.35120882
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34646835
50	P68_20966046_ChIP-Seq_HELA_Human	1.31910909
51	TP63_22573176_ChIP-Seq_HFKS_Human	1.30804655
52	CTCF_20526341_ChIP-Seq_ESCs_Human	1.30283303
53	TP53_18474530_ChIP-ChIP_U2OS_Human	1.29802019
54	BCOR_27268052_Chip-Seq_Bcells_Human	1.29710755
55	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.28860514
56	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.27677481
57	P300_19829295_ChIP-Seq_ESCs_Human	1.26734016
58	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.26587569
59	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.26150844
60	ETV1_20927104_ChIP-Seq_GIST48_Human	1.26075359
61	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.25798584
62	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.23688556
63	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.23683843
64	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23459486
65	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.22867110
66	P300_27268052_Chip-Seq_Bcells_Human	1.22369317
67	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21833746
68	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.21754021
69	RBPJ_21746931_ChIP-Seq_IB4_Human	1.21738024
70	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.19013392
71	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.18720411
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18686173
73	TBL1_22424771_ChIP-Seq_293T_Human	1.17900341
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17853873
75	NFYB_21822215_ChIP-Seq_K562_Human	1.17187448
76	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.16449971
77	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16417571
78	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.15366200
79	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14767167
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14456003
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14163123
82	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.13783389
83	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13763337
84	CEBPB_22108803_ChIP-Seq_LS180_Human	1.13461423
85	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.12112929
86	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.12038817
87	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11997826
88	ERG_20517297_ChIP-Seq_VCAP_Human	1.10707075
89	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.10216839
90	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.09259662
91	P53_21459846_ChIP-Seq_SAOS-2_Human	1.07992015
92	SMRT_27268052_Chip-Seq_Bcells_Human	1.07313985
93	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07191644
94	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.06434081
95	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.06145444
96	NFYA_21822215_ChIP-Seq_K562_Human	1.05920525
97	STAT3_23295773_ChIP-Seq_U87_Human	1.05206057
98	LXR_22292898_ChIP-Seq_THP-1_Human	1.04516736
99	PHF8_20622853_ChIP-Seq_HELA_Human	1.04201157
100	VDR_22108803_ChIP-Seq_LS180_Human	1.00567010

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	4.78647410
2	MP0003878_abnormal_ear_physiology	4.70259062
3	MP0005377_hearing/vestibular/ear_phenot	4.70259062
4	MP0003698_abnormal_male_reproductive	4.28230320
5	MP0001929_abnormal_gametogenesis	3.61616910
6	MP0001348_abnormal_lacrimal_gland	3.55051889
7	MP0000678_abnormal_parathyroid_gland	2.63674913
8	MP0002161_abnormal_fertility/fecundity	2.40565592
9	MP0002822_catalepsy	2.11665249
10	MP0003011_delayed_dark_adaptation	2.06004480
11	MP0005410_abnormal_fertilization	11.7050121
12	MP0002132_abnormal_respiratory_system	1.92347430
13	MP0005379_endocrine/exocrine_gland_phen	1.91978916
14	MP0003718_maternal_effect	1.91689329
15	MP0002249_abnormal_larynx_morphology	1.90183936
16	MP0003646_muscle_fatigue	1.74822980
17	MP0002234_abnormal_pharynx_morphology	1.73299664
18	MP0002282_abnormal_trachea_morphology	1.69523930
19	MP0001485_abnormal_pinna_reflex	1.60654869
20	MP0002210_abnormal_sex_determination	1.60408082
21	MP0002127_abnormal_cardiovascular_syste	1.39934090
22	MP0000534_abnormal_ureter_morphology	1.37584779
23	MP0001486_abnormal_startle_reflex	1.34433925
24	MP0009053_abnormal_anal_canal	1.32181817
25	MP0001145_abnormal_male_reproductive	1.29781887
26	MP0002735_abnormal_chemical_nociception	1.28317789
27	MP0001666_abnormal_nutrient_absorption	1.27397517
28	MP0000653_abnormal_sex_gland	1.27099800
29	MP0005423_abnormal_somatic_nervous	1.21938937
30	MP0000516_abnormal_urinary_system	1.20251208
31	MP0005367_renal/urinary_system_phenotyp	1.20251208
32	MP0004742_abnormal_vestibular_system	1.20130765
33	MP0001765_abnormal_ion_homeostasis	1.19518889
34	MP0002138_abnormal_hepatobiliary_system	1.12875340
35	MP0004859_abnormal_synaptic_plasticity	1.12383839
36	MP0000026_abnormal_inner_ear	1.10921707
37	MP0001963_abnormal_hearing_physiology	1.09594109
38	MP0000566_synostosis	1.05565448
39	MP0003879_abnormal_hair_cell	1.00167084
40	MP0005248_abnormal_Harderian_gland	0.99796305
41	MP0005395_other_phenotype	0.95069346
42	MP0005666_abnormal_adipose_tissue	0.94470250
43	MP0010368_abnormal_lymphatic_system	0.93602661
44	MP0001879_abnormal_lymphatic_vessel	0.91981803
45	MP0000955_abnormal_spinal_cord	0.90874090
46	MP0000003_abnormal_adipose_tissue	0.89912556
47	MP0005375_adipose_tissue_phenotype	0.89814239
48	MP0000049_abnormal_middle_ear	0.87431517
49	MP0001968_abnormal_touch/_nociception	0.86390045
50	MP0002229_neurodegeneration	0.85984832
51	MP0009115_abnormal_fat_cell	0.85765721
52	MP0000681_abnormal_thyroid_gland	0.85398741
53	MP0004510_myositis	0.83586429
54	MP0005451_abnormal_body_composition	0.81824051
55	MP0005551_abnormal_eye_electrophysiolog	0.80912699
56	MP0002557_abnormal_social/conspecific_i	0.80469170
57	MP0008569_lethality_at_weaning	0.76333597
58	MP0004085_abnormal_heartbeat	0.74374890
59	MP0005310_abnormal_salivary_gland	0.74121616
60	MP0002067_abnormal_sensory_capabilities	0.72491054
61	MP0002733_abnormal_thermal_nociception	0.71979317
62	MP0003172_abnormal_lysosome_physiology	0.68708243
63	MP0006292_abnormal_olfactory_placode	0.66537695
64	MP0000569_abnormal_digit_pigmentation	0.61732095
65	MP0005636_abnormal_mineral_homeostasis	0.61032876
66	MP0002572_abnormal_emotion/affect_behav	0.59599907
67	MP0003119_abnormal_digestive_system	0.56668947
68	MP0001270_distended_abdomen	0.55973735
69	MP0008961_abnormal_basal_metabolism	0.55610711
70	MP0005535_abnormal_body_temperature	0.54431649
71	MP0008995_early_reproductive_senescence	0.54223098
72	MP0003091_abnormal_cell_migration	0.54128798
73	MP0009745_abnormal_behavioral_response	0.52792802
74	MP0010329_abnormal_lipoprotein_level	0.52470334
75	MP0004233_abnormal_muscle_weight	0.51608451
76	MP0005167_abnormal_blood-brain_barrier	0.51179611
77	MP0008004_abnormal_stomach_pH	0.50873178
78	MP0005253_abnormal_eye_physiology	0.50579975
79	MP0009384_cardiac_valve_regurgitation	0.47759098
80	MP0001970_abnormal_pain_threshold	0.47384240
81	MP0005503_abnormal_tendon_morphology	0.46514910
82	MP0004484_altered_response_of	0.46215986
83	MP0005275_abnormal_skin_tensile	0.45803790
84	MP0003699_abnormal_female_reproductive	0.45047599
85	MP0005365_abnormal_bile_salt	0.44913668
86	MP0000467_abnormal_esophagus_morphology	0.43847811
87	MP0002928_abnormal_bile_duct	0.43634431
88	MP0001440_abnormal_grooming_behavior	0.43357931
89	MP0001905_abnormal_dopamine_level	0.42290129
90	MP0001501_abnormal_sleep_pattern	0.42286919
91	MP0002734_abnormal_mechanical_nocicepti	0.42033808
92	MP0009697_abnormal_copulation	0.41821581
93	MP0002272_abnormal_nervous_system	0.41555515
94	MP0003936_abnormal_reproductive_system	0.41538681
95	MP0002108_abnormal_muscle_morphology	0.41419198
96	MP0004036_abnormal_muscle_relaxation	0.41333650
97	MP0005647_abnormal_sex_gland	0.41251207
98	MP0003942_abnormal_urinary_system	0.40875998
99	MP0002109_abnormal_limb_morphology	0.40318543
100	MP0002115_abnormal_skeleton_extremities	0.40270026

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.27198968
2	Absent/shortened dynein arms (HP:0200106)	5.23808449
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.23808449
4	Asymmetric septal hypertrophy (HP:0001670)	5.20594258
5	Attenuation of retinal blood vessels (HP:0007843)	5.05607100
6	Bony spicule pigmentary retinopathy (HP:0007737)	4.93252198
7	Hyperkalemia (HP:0002153)	4.78096779
8	Bell-shaped thorax (HP:0001591)	4.62376552
9	Hypoplastic ischia (HP:0003175)	4.52582869
10	Resting tremor (HP:0002322)	4.20653163
11	Tubulointerstitial nephritis (HP:0001970)	4.20458621
12	Enlarged epiphyses (HP:0010580)	4.18883577
13	Facial shape deformation (HP:0011334)	4.15398496
14	Potter facies (HP:0002009)	4.15398496
15	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.02486535
16	Abnormal ciliary motility (HP:0012262)	4.01952057
17	Abnormality of the ischium (HP:0003174)	4.00893962
18	Male infertility (HP:0003251)	3.95129033
19	Abnormal respiratory motile cilium morphology (HP:0005938)	3.92713777
20	Abnormal respiratory epithelium morphology (HP:0012253)	3.92713777
21	Abnormal rod and cone electroretinograms (HP:0008323)	3.87116371
22	Abnormal respiratory motile cilium physiology (HP:0012261)	3.84117946
23	Infertility (HP:0000789)	3.66133422
24	Impulsivity (HP:0100710)	3.65831861
25	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.61054337
26	Abnormality of macular pigmentation (HP:0008002)	3.58573867
27	Chronic hepatic failure (HP:0100626)	3.42486985
28	Nasal polyposis (HP:0100582)	3.27026385
29	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.25640004
30	Abnormality of the aortic arch (HP:0012303)	3.17585100
31	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.15687931
32	Cone-rod dystrophy (HP:0000548)	3.11385077
33	Azoospermia (HP:0000027)	3.08790866
34	Progressive cerebellar ataxia (HP:0002073)	2.95335245
35	Nephronophthisis (HP:0000090)	2.93170272
36	Abnormal spermatogenesis (HP:0008669)	2.91747091
37	Congenital malformation of the right heart (HP:0011723)	2.91311251
38	Double outlet right ventricle (HP:0001719)	2.91311251
39	Unilateral renal agenesis (HP:0000122)	2.73701687
40	Abnormal urine output (HP:0012590)	2.72786441
41	Renal dysplasia (HP:0000110)	2.63776681
42	Postural instability (HP:0002172)	2.63153327
43	Abnormality of potassium homeostasis (HP:0011042)	2.61566428
44	Abnormality of the nasal mucosa (HP:0000433)	2.61428157
45	Abnormality of the renal medulla (HP:0100957)	2.59278252
46	Truncal obesity (HP:0001956)	2.54080191
47	Hypoplasia of the thymus (HP:0000778)	2.53608029
48	Progressive sensorineural hearing impairment (HP:0000408)	2.49080468
49	Epiphyseal dysplasia (HP:0002656)	2.47911617
50	Stage 5 chronic kidney disease (HP:0003774)	2.46586891
51	Abnormality of the costochondral junction (HP:0000919)	2.44346504
52	Hypophosphatemic rickets (HP:0004912)	2.42479301
53	Abnormality of the parathyroid morphology (HP:0011766)	2.41949766
54	Abnormality of renal excretion (HP:0011036)	2.40335100
55	Widely patent fontanelles and sutures (HP:0004492)	2.37479656
56	Hypoalphalipoproteinemia (HP:0003233)	2.37411369
57	Abnormality of the pubic bones (HP:0003172)	2.32062029
58	Generalized aminoaciduria (HP:0002909)	2.31332473
59	Portal hypertension (HP:0001409)	2.25643521
60	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.25171543
61	Absent epiphyses (HP:0010577)	2.25171543
62	Rhinitis (HP:0012384)	2.21338942
63	Short ribs (HP:0000773)	2.18099922
64	Neoplasm of the heart (HP:0100544)	2.17736899
65	Abnormality of dental color (HP:0011073)	2.16745116
66	Tubulointerstitial abnormality (HP:0001969)	2.15445179
67	Intellectual disability, moderate (HP:0002342)	2.15158956
68	Abnormality of chloride homeostasis (HP:0011422)	2.11365996
69	Polyuria (HP:0000103)	2.08643265
70	Abnormality of the hepatic vasculature (HP:0006707)	2.08561205
71	Hyponatremia (HP:0002902)	2.06175033
72	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.05863732
73	Spastic paraparesis (HP:0002313)	2.04411148
74	Polydipsia (HP:0001959)	2.03046142
75	Abnormal drinking behavior (HP:0030082)	2.03046142
76	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	2.01063071
77	Abnormality of femoral epiphyses (HP:0006499)	2.01063071
78	Renovascular hypertension (HP:0100817)	1.98918428
79	Protuberant abdomen (HP:0001538)	1.96303915
80	Decreased central vision (HP:0007663)	1.94058318
81	Abnormal ventriculo-arterial connection (HP:0011563)	1.92060896
82	Transposition of the great arteries (HP:0001669)	1.92060896
83	Abnormal connection of the cardiac segments (HP:0011545)	1.92060896
84	Abnormality of the femoral head (HP:0003368)	1.91094075
85	Amelogenesis imperfecta (HP:0000705)	1.83498848
86	Flattened epiphyses (HP:0003071)	1.83171447
87	Atelectasis (HP:0100750)	1.83014928
88	Occipital encephalocele (HP:0002085)	1.81236505
89	Congenital sensorineural hearing impairment (HP:0008527)	1.80430620
90	Bulbous nose (HP:0000414)	1.80272834
91	Tubular atrophy (HP:0000092)	1.79761003
92	Neonatal short-limb short stature (HP:0008921)	1.76460610
93	Bradycardia (HP:0001662)	1.75132903
94	Atrophic scars (HP:0001075)	1.74809978
95	Ventricular tachycardia (HP:0004756)	1.73756725
96	Recurrent corneal erosions (HP:0000495)	1.72393651
97	Peritonitis (HP:0002586)	1.71438845
98	Abnormality of the nasal septum (HP:0000419)	1.69738447
99	Chronic bronchitis (HP:0004469)	1.66116122
100	Mixed hearing impairment (HP:0000410)	1.65674179

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.55504922
2	TESK1	5.58879892
3	DDR2	5.22945506
4	STK38	3.23510427
5	INSRR	3.02724038
6	PNCK	3.02364402
7	MST1R	2.97730685
8	MAP4K2	2.92774284
9	BRD4	2.88902783
10	MAPK15	2.73067887
11	PLK2	2.65269374
12	WNK1	2.43099702
13	CAMK1G	2.43069730
14	PRKD3	2.17945481
15	WNK4	2.09037126
16	STK38L	1.98318368
17	CDK12	1.92772300
18	PDPK1	1.46223096
19	PDK1	1.37861134
20	CDK7	1.32054721
21	DYRK1B	1.31403502
22	CAMK1D	1.18115410
23	PIK3CG	1.13043213
24	MAP3K9	1.09763890
25	SIK2	1.03618067
26	PTK2B	1.00597880
27	MARK1	0.90509403
28	NEK6	0.86490077
29	LATS2	0.84426730
30	PRKAA2	0.82964940
31	UHMK1	0.81312217
32	MET	0.80043481
33	STK39	0.79521636
34	AKT3	0.78899191
35	PRKG1	0.78291981
36	BMPR1B	0.76549846
37	TIE1	0.75885891
38	KSR2	0.72160941
39	TNIK	0.71853078
40	RPS6KA2	0.70871368
41	PRKG2	0.62696444
42	ROCK1	0.62249129
43	CDK3	0.61178841
44	MTOR	0.59293892
45	RPS6KA1	0.58217045
46	MAP3K11	0.56905365
47	FRK	0.55100646
48	TYRO3	0.54516712
49	GSK3B	0.53668951
50	SGK1	0.52744981
51	MAP3K4	0.51465941
52	TRPM7	0.50580738
53	LATS1	0.49140618
54	CDK2	0.49114430
55	MAPK1	0.48042214
56	CDK1	0.46217564
57	CASK	0.45786094
58	CAMK1	0.44908492
59	ACVR1B	0.43762660
60	MAPK8	0.40299537
61	FER	0.39170547
62	RPS6KC1	0.38740509
63	RPS6KL1	0.38740509
64	CHEK1	0.38456282
65	PRKCG	0.37281455
66	CAMK4	0.36763585
67	NTRK3	0.35906670
68	FGFR2	0.35887695
69	FGFR3	0.35504476
70	MAP2K2	0.35466782
71	RPS6KA6	0.34819454
72	PRKCZ	0.34342449
73	MAP3K7	0.32896005
74	MAPK14	0.31617064
75	MUSK	0.31375906
76	MAP3K1	0.31330513
77	OXSR1	0.31152794
78	PRKAA1	0.30957811
79	MAP3K2	0.30746309
80	SGK494	0.30739741
81	SGK223	0.30739741
82	NME1	0.30484907
83	MAP3K8	0.26837685
84	MAPK10	0.26369782
85	NEK2	0.26196157
86	MARK2	0.26142901
87	PRKCB	0.24377430
88	AKT1	0.24292578
89	BRAF	0.23916459
90	PRKACB	0.19442279
91	CDK4	0.16744519
92	WNK3	0.15989017
93	MAPK11	0.15907147
94	RPS6KA3	0.14904102
95	PRKCE	0.14423661
96	BLK	0.13761336
97	MAP2K4	0.13180577
98	PKN1	0.12092779
99	ERBB2	0.11457124
100	PRKACA	0.10588012

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.37882199
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.12038748
3	Olfactory transduction_Homo sapiens_hsa04740	3.39588809
4	Butanoate metabolism_Homo sapiens_hsa00650	2.79625012
5	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.12065192
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.97229588
7	Taste transduction_Homo sapiens_hsa04742	1.86785244
8	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.80785666
9	Type II diabetes mellitus_Homo sapiens_hsa04930	1.60595759
10	Fatty acid degradation_Homo sapiens_hsa00071	1.58915189
11	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.54946386
12	Protein digestion and absorption_Homo sapiens_hsa04974	1.51227549
13	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.43086954
14	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.42756022
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.40940998
16	Fatty acid metabolism_Homo sapiens_hsa01212	1.36705462
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.32284733
18	Arginine and proline metabolism_Homo sapiens_hsa00330	1.29208021
19	Salivary secretion_Homo sapiens_hsa04970	1.27987902
20	ABC transporters_Homo sapiens_hsa02010	1.20045860
21	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.19356815
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.16569219
23	Phenylalanine metabolism_Homo sapiens_hsa00360	1.15705364
24	Oocyte meiosis_Homo sapiens_hsa04114	1.14314502
25	RNA transport_Homo sapiens_hsa03013	1.13962177
26	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.09816131
27	Arginine biosynthesis_Homo sapiens_hsa00220	1.07831399
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02659757
29	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.96403849
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96173906
31	PPAR signaling pathway_Homo sapiens_hsa03320	0.95709330
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.94972765
33	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.92062492
34	Endocytosis_Homo sapiens_hsa04144	0.90864081
35	Circadian entrainment_Homo sapiens_hsa04713	0.90746167
36	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.90379071
37	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.90345628
38	Phototransduction_Homo sapiens_hsa04744	0.89599783
39	Estrogen signaling pathway_Homo sapiens_hsa04915	0.88415310
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.88412088
41	Calcium signaling pathway_Homo sapiens_hsa04020	0.88113835
42	Selenocompound metabolism_Homo sapiens_hsa00450	0.87912580
43	ECM-receptor interaction_Homo sapiens_hsa04512	0.84551990
44	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84480413
45	Allograft rejection_Homo sapiens_hsa05330	0.84277275
46	cAMP signaling pathway_Homo sapiens_hsa04024	0.81644426
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.81265207
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.80713212
49	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.80686789
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.80604042
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79040191
52	Lysine degradation_Homo sapiens_hsa00310	0.77014142
53	Morphine addiction_Homo sapiens_hsa05032	0.76572150
54	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.75539893
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.74147426
56	Retinol metabolism_Homo sapiens_hsa00830	0.73197853
57	Bile secretion_Homo sapiens_hsa04976	0.71712825
58	Nicotine addiction_Homo sapiens_hsa05033	0.71261373
59	Insulin secretion_Homo sapiens_hsa04911	0.70902504
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70293436
61	Graft-versus-host disease_Homo sapiens_hsa05332	0.68105325
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66775489
63	Antigen processing and presentation_Homo sapiens_hsa04612	0.66273649
64	Renin secretion_Homo sapiens_hsa04924	0.65135425
65	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.65053236
66	Tight junction_Homo sapiens_hsa04530	0.63585535
67	Gastric acid secretion_Homo sapiens_hsa04971	0.57938735
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.57696068
69	Renin-angiotensin system_Homo sapiens_hsa04614	0.57144508
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.56602480
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.53396346
72	Circadian rhythm_Homo sapiens_hsa04710	0.53122166
73	Cholinergic synapse_Homo sapiens_hsa04725	0.52433328
74	Basal transcription factors_Homo sapiens_hsa03022	0.51632716
75	Acute myeloid leukemia_Homo sapiens_hsa05221	0.50641911
76	MAPK signaling pathway_Homo sapiens_hsa04010	0.49738302
77	Serotonergic synapse_Homo sapiens_hsa04726	0.47348292
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.47174514
79	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.46085945
80	Choline metabolism in cancer_Homo sapiens_hsa05231	0.45046690
81	Pancreatic secretion_Homo sapiens_hsa04972	0.44542350
82	Viral myocarditis_Homo sapiens_hsa05416	0.44275166
83	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.44072930
84	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.43101799
85	GABAergic synapse_Homo sapiens_hsa04727	0.42608086
86	Propanoate metabolism_Homo sapiens_hsa00640	0.42432224
87	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.42025628
88	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.39851282
89	Prolactin signaling pathway_Homo sapiens_hsa04917	0.38469217
90	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37517754
91	mTOR signaling pathway_Homo sapiens_hsa04150	0.37493471
92	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36322070
93	Influenza A_Homo sapiens_hsa05164	0.36261530
94	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.35830874
95	Purine metabolism_Homo sapiens_hsa00230	0.35634539
96	Insulin resistance_Homo sapiens_hsa04931	0.32476709
97	VEGF signaling pathway_Homo sapiens_hsa04370	0.31495691
98	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.30687725
99	Adherens junction_Homo sapiens_hsa04520	0.29696426
100	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.26942173

GOLGA6L5P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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