ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	9.77605894
2	sperm capacitation (GO:0048240)	9.19721126
3	chromosome condensation (GO:0030261)	8.86514271
4	DNA packaging (GO:0006323)	8.70017198
5	single strand break repair (GO:0000012)	8.53598530
6	spermatid nucleus differentiation (GO:0007289)	8.06706441
7	plasma membrane fusion (GO:0045026)	7.76523944
8	spermatid development (GO:0007286)	7.70264726
9	microtubule depolymerization (GO:0007019)	7.10783822
10	sexual reproduction (GO:0019953)	6.99204151
11	sperm-egg recognition (GO:0035036)	6.91626616
12	multicellular organism reproduction (GO:0032504)	6.54206911
13	calcium ion-dependent exocytosis (GO:0017156)	6.43791052
14	reproduction (GO:0000003)	6.43262297
15	protein polyglutamylation (GO:0018095)	6.38489400
16	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.23430262
17	binding of sperm to zona pellucida (GO:0007339)	6.20995930
18	microtubule polymerization or depolymerization (GO:0031109)	6.07805152
19	axonemal dynein complex assembly (GO:0070286)	5.98053035
20	rRNA methylation (GO:0031167)	5.85671771
21	negative regulation of inclusion body assembly (GO:0090084)	5.83113883
22	phosphatidylethanolamine metabolic process (GO:0046337)	5.79720152
23	cell-cell recognition (GO:0009988)	5.70921683
24	positive regulation of Rab GTPase activity (GO:0032851)	5.67389795
25	regulation of Rab GTPase activity (GO:0032313)	5.67389795
26	microtubule severing (GO:0051013)	5.67319753
27	protein targeting to Golgi (GO:0000042)	5.66426656
28	establishment of protein localization to Golgi (GO:0072600)	5.59602235
29	spermatogenesis (GO:0007283)	5.57908344
30	male gamete generation (GO:0048232)	5.56184146
31	centriole replication (GO:0007099)	5.52158363
32	cellular ketone body metabolic process (GO:0046950)	5.41598989
33	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.27974627
34	regulation of cilium movement (GO:0003352)	5.26153664
35	chromatin silencing (GO:0006342)	5.12521791
36	gamete generation (GO:0007276)	5.07551636
37	regulation of transcription involved in cell fate commitment (GO:0060850)	5.07245440
38	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.95758397
39	cilium or flagellum-dependent cell motility (GO:0001539)	4.93476307
40	rRNA modification (GO:0000154)	4.82206162
41	ketone body metabolic process (GO:1902224)	4.76616788
42	motile cilium assembly (GO:0044458)	4.74042349
43	centriole assembly (GO:0098534)	4.67286306
44	cell wall macromolecule metabolic process (GO:0044036)	4.54806321
45	single fertilization (GO:0007338)	4.44356807
46	germ cell development (GO:0007281)	4.40853343
47	cell wall macromolecule catabolic process (GO:0016998)	4.27084075
48	RNA destabilization (GO:0050779)	4.24595594
49	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.22384873
50	regulation of inclusion body assembly (GO:0090083)	4.12622591
51	protein localization to Golgi apparatus (GO:0034067)	4.09942031
52	regulation of centriole replication (GO:0046599)	4.09534896
53	multicellular organismal reproductive process (GO:0048609)	4.05990422
54	coenzyme catabolic process (GO:0009109)	3.91673213
55	epithelial cilium movement (GO:0003351)	3.87099405
56	nucleus organization (GO:0006997)	3.79405653
57	peptidyl-threonine dephosphorylation (GO:0035970)	3.76730622
58	musculoskeletal movement (GO:0050881)	3.76409677
59	multicellular organismal movement (GO:0050879)	3.76409677
60	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.75823567
61	fertilization (GO:0009566)	3.68352244
62	organic cation transport (GO:0015695)	3.63893310
63	negative regulation of Rho protein signal transduction (GO:0035024)	3.62858558
64	regulation of microtubule-based movement (GO:0060632)	3.60832251
65	cerebral cortex neuron differentiation (GO:0021895)	3.53238932
66	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.51041969
67	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.51041969
68	cilium movement (GO:0003341)	3.49972473
69	negative regulation of gene expression, epigenetic (GO:0045814)	3.49269765
70	response to acidic pH (GO:0010447)	3.48175629
71	seminiferous tubule development (GO:0072520)	3.39646779
72	NAD biosynthetic process (GO:0009435)	3.35937909
73	protein-DNA complex disassembly (GO:0032986)	3.35767147
74	nucleosome disassembly (GO:0006337)	3.35767147
75	cellular response to pH (GO:0071467)	3.33338005
76	cranial nerve morphogenesis (GO:0021602)	3.16482535
77	regulation of somitogenesis (GO:0014807)	3.14493446
78	glycerol ether metabolic process (GO:0006662)	3.10383527
79	regulation of interleukin-13 production (GO:0032656)	3.09563937
80	regulation of ARF GTPase activity (GO:0032312)	3.06940507
81	regulation of female gonad development (GO:2000194)	3.06698246
82	regulation of T-helper 2 cell differentiation (GO:0045628)	3.05311331
83	Golgi to endosome transport (GO:0006895)	3.03444232
84	polyamine biosynthetic process (GO:0006596)	3.00179112
85	histone H3-K9 demethylation (GO:0033169)	2.97884984
86	homeostasis of number of cells within a tissue (GO:0048873)	2.94681846
87	multicellular organismal development (GO:0007275)	2.92617433
88	negative regulation of histone methylation (GO:0031061)	2.88622481
89	DNA methylation involved in gamete generation (GO:0043046)	2.88009376
90	ether metabolic process (GO:0018904)	2.86455673
91	cell differentiation involved in metanephros development (GO:0072202)	2.85482342
92	cell recognition (GO:0008037)	2.81323921
93	receptor recycling (GO:0001881)	2.78342734
94	peptidyl-proline hydroxylation (GO:0019511)	2.78255069
95	alanine transport (GO:0032328)	2.76885196
96	regulation of interleukin-5 production (GO:0032674)	2.71427109
97	DNA conformation change (GO:0071103)	2.70478365
98	acrosome reaction (GO:0007340)	11.6986117
99	sperm motility (GO:0030317)	11.1684424
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.2659980

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.40517408
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.60575723
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.16072436
4	DROSHA_22980978_ChIP-Seq_HELA_Human	2.33661043
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.30827379
6	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30827379
7	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.17216044
8	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.97948057
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.97785284
10	CBP_20019798_ChIP-Seq_JUKART_Human	1.97700251
11	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.97700251
12	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.91990122
13	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.87157319
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83760485
15	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83521139
16	* ERA_21632823_ChIP-Seq_H3396_Human	1.81744455
17	CTCF_27219007_Chip-Seq_Bcells_Human	1.78785797
18	NANOG_20526341_ChIP-Seq_ESCs_Human	1.77285310
19	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.73530084
20	RAC3_21632823_ChIP-Seq_H3396_Human	1.72115172
21	E2F1_20622854_ChIP-Seq_HELA_Human	1.69461967
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67889009
23	SMC4_20622854_ChIP-Seq_HELA_Human	1.67294393
24	BCL6_27268052_Chip-Seq_Bcells_Human	1.66894119
25	* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.62085351
26	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.61639499
27	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.60946400
28	P68_20966046_ChIP-Seq_HELA_Human	1.60096547
29	PHF8_20622854_ChIP-Seq_HELA_Human	1.59171620
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56015031
31	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.55913105
32	BCOR_27268052_Chip-Seq_Bcells_Human	1.55899184
33	* WDR5_24793694_ChIP-Seq_LNCAP_Human	1.52319688
34	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.52093739
35	TAF2_19829295_ChIP-Seq_ESCs_Human	1.51173361
36	* OCT4_20526341_ChIP-Seq_ESCs_Human	1.48915886
37	CTCF_20526341_ChIP-Seq_ESCs_Human	1.48024493
38	MYC_19829295_ChIP-Seq_ESCs_Human	1.46088049
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.45252360
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.42912078
41	TP63_22573176_ChIP-Seq_HFKS_Human	1.41792672
42	* ER_23166858_ChIP-Seq_MCF-7_Human	1.40703436
43	LXR_22292898_ChIP-Seq_THP-1_Human	1.40305382
44	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.39000067
45	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.38846241
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38403794
47	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.37736892
48	P300_27268052_Chip-Seq_Bcells_Human	1.37458800
49	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.37357550
50	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.35216869
51	* AR_25329375_ChIP-Seq_VCAP_Human	1.34982781
52	FUS_26573619_Chip-Seq_HEK293_Human	1.33766892
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33457418
54	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.32423288
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31394703
56	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.30278908
57	P53_21459846_ChIP-Seq_SAOS-2_Human	1.23081228
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22945669
59	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.22522291
60	CEBPB_22108803_ChIP-Seq_LS180_Human	1.21255214
61	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20648710
62	P300_19829295_ChIP-Seq_ESCs_Human	1.18642903
63	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.18232208
64	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.17088184
65	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.16963200
66	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.16465008
67	ERG_20517297_ChIP-Seq_VCAP_Human	1.15333274
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14991371
69	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.14765524
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14357897
71	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.14231820
72	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.14090965
73	RBPJ_21746931_ChIP-Seq_IB4_Human	1.13796746
74	TP53_18474530_ChIP-ChIP_U2OS_Human	1.13460051
75	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.13078211
76	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.11959380
77	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.11266430
78	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10747655
79	ETV1_20927104_ChIP-Seq_GIST48_Human	1.10274829
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10103001
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09754057
82	TAF15_26573619_Chip-Seq_HEK293_Human	1.08969306
83	SA1_27219007_Chip-Seq_Bcells_Human	1.08687918
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07303251
85	OCT4_19829295_ChIP-Seq_ESCs_Human	1.06501680
86	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06480493
87	NFYB_21822215_ChIP-Seq_K562_Human	1.05391236
88	TBL1_22424771_ChIP-Seq_293T_Human	1.04749864
89	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03456773
90	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03456773
91	* SMRT_27268052_Chip-Seq_Bcells_Human	1.02823958
92	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.02152103
93	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.01974563
94	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01349778
95	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01208073
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.00812285
97	STAT3_23295773_ChIP-Seq_U87_Human	1.00536907
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.99246185
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98970102
100	SMAD4_21799915_ChIP-Seq_A2780_Human	0.98896382

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	5.12545479
2	MP0003878_abnormal_ear_physiology	5.12545479
3	MP0005670_abnormal_white_adipose	5.05216458
4	MP0003698_abnormal_male_reproductive	4.11158608
5	MP0001348_abnormal_lacrimal_gland	4.09502629
6	MP0001929_abnormal_gametogenesis	3.44483368
7	MP0000678_abnormal_parathyroid_gland	2.64547827
8	MP0002822_catalepsy	2.48673349
9	MP0003646_muscle_fatigue	2.37585726
10	MP0002161_abnormal_fertility/fecundity	2.27394143
11	MP0005410_abnormal_fertilization	11.3680675
12	MP0003718_maternal_effect	1.93093340
13	MP0005379_endocrine/exocrine_gland_phen	1.91574875
14	MP0002735_abnormal_chemical_nociception	1.76042909
15	MP0002249_abnormal_larynx_morphology	1.72657494
16	MP0002132_abnormal_respiratory_system	1.68213967
17	MP0002234_abnormal_pharynx_morphology	1.66605798
18	MP0005423_abnormal_somatic_nervous	1.63177960
19	MP0001486_abnormal_startle_reflex	1.59409984
20	MP0001485_abnormal_pinna_reflex	1.57479694
21	MP0009053_abnormal_anal_canal	1.57138480
22	MP0003879_abnormal_hair_cell	1.54401004
23	MP0003011_delayed_dark_adaptation	1.53187557
24	MP0002210_abnormal_sex_determination	1.52867342
25	MP0002138_abnormal_hepatobiliary_system	1.45121679
26	MP0000534_abnormal_ureter_morphology	1.34107808
27	MP0001968_abnormal_touch/_nociception	1.32243833
28	MP0001145_abnormal_male_reproductive	1.22295717
29	MP0000653_abnormal_sex_gland	1.19721297
30	MP0002282_abnormal_trachea_morphology	1.19640147
31	MP0004859_abnormal_synaptic_plasticity	1.18850284
32	MP0001963_abnormal_hearing_physiology	1.17325023
33	MP0001765_abnormal_ion_homeostasis	1.14337795
34	MP0004742_abnormal_vestibular_system	1.13500189
35	MP0002653_abnormal_ependyma_morphology	1.12864440
36	MP0002733_abnormal_thermal_nociception	1.11110193
37	MP0000026_abnormal_inner_ear	1.09247762
38	MP0005395_other_phenotype	1.07199895
39	MP0001905_abnormal_dopamine_level	1.05696446
40	MP0008569_lethality_at_weaning	1.02668024
41	MP0009745_abnormal_behavioral_response	0.98826696
42	MP0005310_abnormal_salivary_gland	0.97514833
43	MP0001501_abnormal_sleep_pattern	0.96406778
44	MP0002127_abnormal_cardiovascular_syste	0.95278307
45	MP0002229_neurodegeneration	0.94785959
46	MP0005248_abnormal_Harderian_gland	0.91930827
47	MP0005451_abnormal_body_composition	0.91456426
48	MP0000955_abnormal_spinal_cord	0.90938958
49	MP0002067_abnormal_sensory_capabilities	0.90580494
50	MP0002557_abnormal_social/conspecific_i	0.90520948
51	MP0004510_myositis	0.89394878
52	MP0005551_abnormal_eye_electrophysiolog	0.88630290
53	MP0004233_abnormal_muscle_weight	0.88078184
54	MP0000681_abnormal_thyroid_gland	0.87464648
55	MP0003136_yellow_coat_color	0.87423279
56	MP0000049_abnormal_middle_ear	0.87167137
57	MP0001440_abnormal_grooming_behavior	0.87079441
58	MP0002837_dystrophic_cardiac_calcinosis	0.85778549
59	MP0001970_abnormal_pain_threshold	0.84467789
60	MP0002572_abnormal_emotion/affect_behav	0.83790646
61	MP0009115_abnormal_fat_cell	0.81078018
62	MP0004085_abnormal_heartbeat	0.78249091
63	MP0005666_abnormal_adipose_tissue	0.77377754
64	MP0002272_abnormal_nervous_system	0.71037652
65	MP0002734_abnormal_mechanical_nocicepti	0.68205171
66	MP0003119_abnormal_digestive_system	0.67473263
67	MP0006276_abnormal_autonomic_nervous	0.67081049
68	MP0003137_abnormal_impulse_conducting	0.64785415
69	MP0006292_abnormal_olfactory_placode	0.63884304
70	MP0005375_adipose_tissue_phenotype	0.63225550
71	MP0003635_abnormal_synaptic_transmissio	0.62545304
72	MP0005535_abnormal_body_temperature	0.62335226
73	MP0005167_abnormal_blood-brain_barrier	0.59865187
74	MP0008877_abnormal_DNA_methylation	0.59165502
75	MP0005253_abnormal_eye_physiology	0.58980267
76	MP0000470_abnormal_stomach_morphology	0.58883379
77	MP0001879_abnormal_lymphatic_vessel	0.58872247
78	MP0002168_other_aberrant_phenotype	0.55049436
79	MP0009046_muscle_twitch	0.54176173
80	MP0005083_abnormal_biliary_tract	0.52023406
81	MP0009697_abnormal_copulation	0.51763063
82	MP0002928_abnormal_bile_duct	0.51284176
83	MP0008961_abnormal_basal_metabolism	0.50981802
84	MP0003045_fibrosis	0.50431825
85	MP0001666_abnormal_nutrient_absorption	0.49853349
86	MP0005636_abnormal_mineral_homeostasis	0.47696383
87	MP0000516_abnormal_urinary_system	0.47133516
88	MP0005367_renal/urinary_system_phenotyp	0.47133516
89	MP0002064_seizures	0.45502315
90	MP0000003_abnormal_adipose_tissue	0.45404359
91	MP0004484_altered_response_of	0.44282019
92	MP0002882_abnormal_neuron_morphology	0.43387329
93	MP0003942_abnormal_urinary_system	0.43058833
94	MP0003880_abnormal_central_pattern	0.42854706
95	MP0000569_abnormal_digit_pigmentation	0.40339320
96	MP0005647_abnormal_sex_gland	0.38748035
97	MP0003699_abnormal_female_reproductive	0.38373684
98	MP0002752_abnormal_somatic_nervous	0.36678454
99	MP0003631_nervous_system_phenotype	0.36274520
100	MP0004036_abnormal_muscle_relaxation	0.35957404

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.29999937
2	Absent/shortened dynein arms (HP:0200106)	5.85510856
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.85510856
4	Bony spicule pigmentary retinopathy (HP:0007737)	5.32844164
5	Attenuation of retinal blood vessels (HP:0007843)	5.19498342
6	Asymmetric septal hypertrophy (HP:0001670)	5.17098611
7	Abnormal ciliary motility (HP:0012262)	4.64425454
8	Bell-shaped thorax (HP:0001591)	4.53451434
9	Facial shape deformation (HP:0011334)	4.49546907
10	Potter facies (HP:0002009)	4.49546907
11	Hyperkalemia (HP:0002153)	4.49520253
12	Abnormal respiratory motile cilium physiology (HP:0012261)	4.35092037
13	Abnormal respiratory motile cilium morphology (HP:0005938)	4.34953348
14	Abnormal respiratory epithelium morphology (HP:0012253)	4.34953348
15	Hypoplastic ischia (HP:0003175)	4.27932456
16	Abnormal rod and cone electroretinograms (HP:0008323)	4.06083782
17	Abnormality of macular pigmentation (HP:0008002)	3.95239861
18	Infertility (HP:0000789)	3.88796901
19	Male infertility (HP:0003251)	3.88435981
20	Resting tremor (HP:0002322)	3.84471597
21	Progressive cerebellar ataxia (HP:0002073)	3.82678805
22	Tubulointerstitial nephritis (HP:0001970)	3.81377146
23	Abnormality of the ischium (HP:0003174)	3.76946841
24	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.73217693
25	Chronic hepatic failure (HP:0100626)	3.70606222
26	Enlarged epiphyses (HP:0010580)	3.61554448
27	Nasal polyposis (HP:0100582)	3.60471433
28	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.56662132
29	Impulsivity (HP:0100710)	3.48346004
30	Postural instability (HP:0002172)	3.35727642
31	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.34376429
32	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.31884054
33	Unilateral renal agenesis (HP:0000122)	3.19328989
34	Amelogenesis imperfecta (HP:0000705)	3.17956331
35	Nephronophthisis (HP:0000090)	3.06316568
36	Abnormal spermatogenesis (HP:0008669)	3.05579831
37	Azoospermia (HP:0000027)	3.01630791
38	Cone-rod dystrophy (HP:0000548)	3.00893020
39	Abnormal urine output (HP:0012590)	2.97907371
40	Abnormality of the nasal mucosa (HP:0000433)	2.85534304
41	Abnormality of potassium homeostasis (HP:0011042)	2.83312678
42	Genetic anticipation (HP:0003743)	2.74314268
43	Double outlet right ventricle (HP:0001719)	2.64914217
44	Congenital malformation of the right heart (HP:0011723)	2.64914217
45	Renal dysplasia (HP:0000110)	2.61537567
46	Abnormality of the renal medulla (HP:0100957)	2.60754351
47	Polydipsia (HP:0001959)	2.58249959
48	Abnormal drinking behavior (HP:0030082)	2.58249959
49	Hypoplasia of the thymus (HP:0000778)	2.58202877
50	Abnormality of the aortic arch (HP:0012303)	2.57988309
51	Abnormality of renal excretion (HP:0011036)	2.57907960
52	Rhinitis (HP:0012384)	2.47492701
53	Epiphyseal dysplasia (HP:0002656)	2.44825501
54	Polyuria (HP:0000103)	2.42561013
55	Abnormality of the pubic bones (HP:0003172)	2.39386105
56	Stage 5 chronic kidney disease (HP:0003774)	2.34233982
57	Generalized aminoaciduria (HP:0002909)	2.32367685
58	Portal hypertension (HP:0001409)	2.28146566
59	Abnormality of the costochondral junction (HP:0000919)	2.22461701
60	Tubulointerstitial abnormality (HP:0001969)	2.21437347
61	Truncal obesity (HP:0001956)	2.20335771
62	Decreased central vision (HP:0007663)	2.18938784
63	Abnormality of the parathyroid morphology (HP:0011766)	2.18005655
64	Widely patent fontanelles and sutures (HP:0004492)	2.10819482
65	Abnormality of dental color (HP:0011073)	2.07994704
66	Progressive sensorineural hearing impairment (HP:0000408)	2.07045609
67	Abnormality of the hepatic vasculature (HP:0006707)	2.05903400
68	Bronchiectasis (HP:0002110)	2.05585394
69	Retinal dysplasia (HP:0007973)	2.04105593
70	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.02701314
71	Absent epiphyses (HP:0010577)	2.02701314
72	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.00897314
73	Hypophosphatemic rickets (HP:0004912)	1.98059476
74	Mixed hearing impairment (HP:0000410)	1.95788601
75	Hypokalemia (HP:0002900)	1.94912223
76	Tubular atrophy (HP:0000092)	1.93131527
77	Renovascular hypertension (HP:0100817)	1.91973328
78	Hyperthyroidism (HP:0000836)	1.91908740
79	Neoplasm of the heart (HP:0100544)	1.90803924
80	Hyponatremia (HP:0002902)	1.90729947
81	Tetany (HP:0001281)	1.89050545
82	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.88402681
83	Spastic paraparesis (HP:0002313)	1.85806138
84	Cerebellar dysplasia (HP:0007033)	1.85105056
85	Flattened epiphyses (HP:0003071)	1.84703615
86	Hypoalphalipoproteinemia (HP:0003233)	1.83553812
87	Congenital sensorineural hearing impairment (HP:0008527)	1.82195558
88	Abnormal ventriculo-arterial connection (HP:0011563)	1.81057314
89	Transposition of the great arteries (HP:0001669)	1.81057314
90	Abnormal connection of the cardiac segments (HP:0011545)	1.81057314
91	Ventricular tachycardia (HP:0004756)	1.80568720
92	Short ribs (HP:0000773)	1.77208176
93	Insulin-resistant diabetes mellitus (HP:0000831)	1.74922881
94	Abnormality of femoral epiphyses (HP:0006499)	1.74569369
95	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.74569369
96	Chronic bronchitis (HP:0004469)	1.72054851
97	Osteomalacia (HP:0002749)	1.71960635
98	Photophobia (HP:0000613)	1.71247471
99	Atelectasis (HP:0100750)	1.71156557
100	Myokymia (HP:0002411)	1.70966620

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.58643336
2	TESK1	6.03923472
3	DDR2	5.07925122
4	STK38	3.69349973
5	INSRR	3.42399278
6	STK38L	3.32819224
7	MAP4K2	2.78571836
8	PLK2	2.69258892
9	PRKD3	2.57135414
10	MAPK15	2.52363583
11	PNCK	2.39205916
12	LATS1	2.20771773
13	CAMK1G	2.10040249
14	LATS2	2.01624321
15	BRD4	1.93820060
16	MST1R	1.86330385
17	PDPK1	1.76314354
18	WNK1	1.57842834
19	FRK	1.46853020
20	PDK1	1.43661763
21	PIK3CG	1.37097830
22	SIK2	1.35735054
23	CDK7	1.30782995
24	CDK12	1.20476149
25	MAP3K9	1.20221987
26	PTK2B	1.20002041
27	DYRK1B	1.17955335
28	BMPR1B	1.03691630
29	PRKAA2	0.98307673
30	PRKG2	0.97116622
31	MAP2K2	0.94296029
32	KSR2	0.90892622
33	CAMK1D	0.88205238
34	NEK6	0.85217255
35	WNK4	0.83977969
36	AKT3	0.81373320
37	RPS6KA2	0.74269924
38	UHMK1	0.73472934
39	ACVR1B	0.70613835
40	PRKG1	0.68356468
41	RPS6KA1	0.63474376
42	NTRK3	0.62484333
43	MAP3K2	0.60063125
44	BRAF	0.56888533
45	ZAK	0.56509075
46	STK39	0.50568664
47	RPS6KA6	0.48329966
48	MAP3K11	0.48025029
49	PRKCG	0.47436042
50	NEK2	0.47290159
51	GSK3B	0.45992309
52	MAP3K8	0.45827646
53	CAMK1	0.45628131
54	RPS6KC1	0.43118027
55	RPS6KL1	0.43118027
56	CDK3	0.40996415
57	MTOR	0.40854470
58	CDK2	0.40685537
59	ROCK1	0.40130972
60	MARK1	0.39382761
61	MAPK1	0.39195760
62	ADRBK2	0.38973564
63	CDK4	0.38831109
64	MAPK8	0.38797490
65	ICK	0.37451678
66	RIPK4	0.37364656
67	PKN1	0.37227912
68	SGK494	0.36936595
69	SGK223	0.36936595
70	CDK1	0.36306752
71	MUSK	0.34617126
72	TYRO3	0.34208180
73	OXSR1	0.33888508
74	TNK2	0.32756065
75	MAPK11	0.31891166
76	TAF1	0.30029294
77	SGK1	0.28293170
78	CAMK4	0.28063654
79	MARK2	0.28010860
80	PRKCE	0.27189889
81	MET	0.26686700
82	PRKCB	0.26200509
83	PRKCZ	0.25918530
84	TESK2	0.25479334
85	CHEK1	0.24134139
86	PRKAA1	0.23296557
87	FER	0.23142770
88	STK3	0.22922916
89	MAPK14	0.21729218
90	AKT1	0.20872704
91	MAP3K1	0.19916172
92	GRK7	0.17682882
93	MAP3K4	0.15298888
94	JAK3	0.14361286
95	MAPK10	0.13961605
96	STK16	0.13906198
97	PRKACB	0.13378156
98	PRKACA	0.13204345
99	PRKCH	0.12959360
100	IKBKB	0.10998812

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.79557707
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.08370846
3	Olfactory transduction_Homo sapiens_hsa04740	3.54775100
4	Butanoate metabolism_Homo sapiens_hsa00650	2.60093435
5	Taste transduction_Homo sapiens_hsa04742	2.22353212
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.97567020
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.93293459
8	Phototransduction_Homo sapiens_hsa04744	1.84120153
9	Nicotine addiction_Homo sapiens_hsa05033	1.74821457
10	Type II diabetes mellitus_Homo sapiens_hsa04930	1.71064342
11	Morphine addiction_Homo sapiens_hsa05032	1.65009274
12	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.64938403
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.64632796
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.59679458
15	Allograft rejection_Homo sapiens_hsa05330	1.59139336
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.58117960
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.49888366
18	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.41389716
19	Fatty acid degradation_Homo sapiens_hsa00071	1.38832586
20	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.32649126
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.31261142
22	Phenylalanine metabolism_Homo sapiens_hsa00360	1.26797640
23	Circadian entrainment_Homo sapiens_hsa04713	1.23948415
24	Viral myocarditis_Homo sapiens_hsa05416	1.23202506
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.22915140
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.19638959
27	Arginine and proline metabolism_Homo sapiens_hsa00330	1.18849626
28	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.18687710
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.18427740
30	ABC transporters_Homo sapiens_hsa02010	1.17026892
31	Salivary secretion_Homo sapiens_hsa04970	1.14778019
32	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.09394877
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.09281201
34	GABAergic synapse_Homo sapiens_hsa04727	1.04413723
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03420537
36	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.00856946
37	cAMP signaling pathway_Homo sapiens_hsa04024	0.99004722
38	Glutamatergic synapse_Homo sapiens_hsa04724	0.97424219
39	Protein digestion and absorption_Homo sapiens_hsa04974	0.97398641
40	Glycerolipid metabolism_Homo sapiens_hsa00561	0.93064369
41	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.89452481
42	Gastric acid secretion_Homo sapiens_hsa04971	0.87901563
43	Endocytosis_Homo sapiens_hsa04144	0.87491752
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.84891705
45	Cholinergic synapse_Homo sapiens_hsa04725	0.84605481
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83331748
47	Insulin secretion_Homo sapiens_hsa04911	0.81925186
48	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81903093
49	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.81791582
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.79745739
51	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.77364261
52	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.75813710
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74990094
54	PPAR signaling pathway_Homo sapiens_hsa03320	0.74510704
55	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.74381364
56	Serotonergic synapse_Homo sapiens_hsa04726	0.74177199
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73819514
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.73757697
59	Bile secretion_Homo sapiens_hsa04976	0.73077561
60	Renin-angiotensin system_Homo sapiens_hsa04614	0.71273427
61	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.68457230
62	Oocyte meiosis_Homo sapiens_hsa04114	0.66131471
63	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64949566
64	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.63489390
65	Retinol metabolism_Homo sapiens_hsa00830	0.62605576
66	RNA transport_Homo sapiens_hsa03013	0.61948210
67	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.61917014
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61797504
69	Arginine biosynthesis_Homo sapiens_hsa00220	0.60709507
70	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.59720152
71	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57834012
72	VEGF signaling pathway_Homo sapiens_hsa04370	0.56772497
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54240437
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.53793259
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.51288573
76	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.50114995
77	Renin secretion_Homo sapiens_hsa04924	0.49616690
78	Lysine degradation_Homo sapiens_hsa00310	0.46175456
79	Influenza A_Homo sapiens_hsa05164	0.43724701
80	Purine metabolism_Homo sapiens_hsa00230	0.43181279
81	Basal transcription factors_Homo sapiens_hsa03022	0.43165497
82	Tight junction_Homo sapiens_hsa04530	0.41701482
83	Nitrogen metabolism_Homo sapiens_hsa00910	0.41521174
84	MAPK signaling pathway_Homo sapiens_hsa04010	0.39840997
85	Sphingolipid metabolism_Homo sapiens_hsa00600	0.39388715
86	Linoleic acid metabolism_Homo sapiens_hsa00591	0.38716181
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.34799905
88	Acute myeloid leukemia_Homo sapiens_hsa05221	0.33039295
89	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.30371349
90	ECM-receptor interaction_Homo sapiens_hsa04512	0.30244484
91	Tryptophan metabolism_Homo sapiens_hsa00380	0.30112259
92	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.29716367
93	Pancreatic secretion_Homo sapiens_hsa04972	0.29692176
94	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.27876920
95	Cocaine addiction_Homo sapiens_hsa05030	0.27736167
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.27664706
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.21092170
98	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.19709243
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.19525579
100	Prolactin signaling pathway_Homo sapiens_hsa04917	0.16456304

GOLGA6L6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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