ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	9.77046871
2	response to pheromone (GO:0019236)	9.56721522
3	chromosome condensation (GO:0030261)	9.13727426
4	DNA packaging (GO:0006323)	8.97128431
5	single strand break repair (GO:0000012)	8.34643164
6	spermatid development (GO:0007286)	8.30940378
7	spermatid nucleus differentiation (GO:0007289)	8.25360403
8	plasma membrane fusion (GO:0045026)	8.13003020
9	microtubule depolymerization (GO:0007019)	7.90536746
10	sperm-egg recognition (GO:0035036)	7.36135041
11	multicellular organism reproduction (GO:0032504)	7.05794243
12	sexual reproduction (GO:0019953)	6.89651116
13	negative regulation of inclusion body assembly (GO:0090084)	6.79354302
14	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.77875858
15	protein polyglutamylation (GO:0018095)	6.77623703
16	reproduction (GO:0000003)	6.76795321
17	rRNA methylation (GO:0031167)	6.67002729
18	calcium ion-dependent exocytosis (GO:0017156)	6.63388516
19	binding of sperm to zona pellucida (GO:0007339)	6.58285849
20	microtubule polymerization or depolymerization (GO:0031109)	6.37843737
21	phosphatidylethanolamine metabolic process (GO:0046337)	6.27583384
22	cell-cell recognition (GO:0009988)	6.05951138
23	microtubule severing (GO:0051013)	6.05927486
24	axonemal dynein complex assembly (GO:0070286)	6.03877040
25	protein targeting to Golgi (GO:0000042)	5.89724450
26	cellular ketone body metabolic process (GO:0046950)	5.89090531
27	spermatogenesis (GO:0007283)	5.85435047
28	male gamete generation (GO:0048232)	5.83549533
29	establishment of protein localization to Golgi (GO:0072600)	5.71244519
30	rRNA modification (GO:0000154)	5.60015576
31	regulation of cilium movement (GO:0003352)	5.51949205
32	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.48369046
33	gamete generation (GO:0007276)	5.33589020
34	regulation of Rab GTPase activity (GO:0032313)	5.25162679
35	positive regulation of Rab GTPase activity (GO:0032851)	5.25162679
36	ketone body metabolic process (GO:1902224)	5.19952117
37	centriole replication (GO:0007099)	5.09062427
38	regulation of transcription involved in cell fate commitment (GO:0060850)	5.02176113
39	regulation of inclusion body assembly (GO:0090083)	4.86628990
40	RNA destabilization (GO:0050779)	4.78297530
41	cell wall macromolecule catabolic process (GO:0016998)	4.75248185
42	chromatin silencing (GO:0006342)	4.68131875
43	single fertilization (GO:0007338)	4.61619129
44	germ cell development (GO:0007281)	4.61304811
45	cell wall macromolecule metabolic process (GO:0044036)	4.59998252
46	cilium or flagellum-dependent cell motility (GO:0001539)	4.58020767
47	motile cilium assembly (GO:0044458)	4.56351475
48	centriole assembly (GO:0098534)	4.45984062
49	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.40493095
50	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.36333215
51	multicellular organismal reproductive process (GO:0048609)	4.28809850
52	regulation of microtubule-based movement (GO:0060632)	4.24820061
53	protein localization to Golgi apparatus (GO:0034067)	4.24804306
54	organic cation transport (GO:0015695)	4.04795906
55	nucleus organization (GO:0006997)	4.02074905
56	regulation of somitogenesis (GO:0014807)	3.97104544
57	coenzyme catabolic process (GO:0009109)	3.92729105
58	epithelial cilium movement (GO:0003351)	3.90200079
59	regulation of centriole replication (GO:0046599)	3.88305519
60	peptidyl-threonine dephosphorylation (GO:0035970)	3.82478845
61	fertilization (GO:0009566)	3.77781528
62	negative regulation of Rho protein signal transduction (GO:0035024)	3.76681504
63	polyamine biosynthetic process (GO:0006596)	3.69803464
64	musculoskeletal movement (GO:0050881)	3.68107393
65	multicellular organismal movement (GO:0050879)	3.68107393
66	response to acidic pH (GO:0010447)	3.67547351
67	cerebral cortex neuron differentiation (GO:0021895)	3.60298863
68	protein-DNA complex disassembly (GO:0032986)	3.43804184
69	nucleosome disassembly (GO:0006337)	3.43804184
70	cellular response to pH (GO:0071467)	3.41500287
71	cilium movement (GO:0003341)	3.41178126
72	cranial nerve morphogenesis (GO:0021602)	3.34312123
73	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.26057006
74	glycerol ether metabolic process (GO:0006662)	3.23737178
75	negative regulation of gene expression, epigenetic (GO:0045814)	3.22444374
76	seminiferous tubule development (GO:0072520)	3.21541614
77	regulation of interleukin-13 production (GO:0032656)	3.20193382
78	homeostasis of number of cells within a tissue (GO:0048873)	3.10854190
79	regulation of T-helper 2 cell differentiation (GO:0045628)	3.10820754
80	membrane protein intracellular domain proteolysis (GO:0031293)	3.07160121
81	multicellular organismal development (GO:0007275)	3.06781684
82	ether metabolic process (GO:0018904)	2.99369565
83	histone H3-K9 demethylation (GO:0033169)	2.98639312
84	cell recognition (GO:0008037)	2.96848443
85	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.95570920
86	protein depolymerization (GO:0051261)	2.93015362
87	NAD biosynthetic process (GO:0009435)	2.90999490
88	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.90727763
89	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.89170346
90	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.89170346
91	DNA conformation change (GO:0071103)	2.82500210
92	negative regulation of histone methylation (GO:0031061)	2.81270549
93	tooth mineralization (GO:0034505)	2.80690713
94	cell differentiation involved in metanephros development (GO:0072202)	2.79467286
95	mitochondrial fission (GO:0000266)	2.79000175
96	Golgi to endosome transport (GO:0006895)	2.78974330
97	microtubule nucleation (GO:0007020)	2.76426316
98	acrosome reaction (GO:0007340)	12.1608288
99	sperm motility (GO:0030317)	11.7615177
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.6652044

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.71114141
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.40010081
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.69939115
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.52150140
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.35499656
6	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35499656
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.22931661
8	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.12202567
9	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.12026933
10	CBP_20019798_ChIP-Seq_JUKART_Human	2.09134304
11	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.09134304
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04380395
13	DROSHA_22980978_ChIP-Seq_HELA_Human	2.03404452
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94728138
15	ERA_21632823_ChIP-Seq_H3396_Human	1.94138809
16	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.93194781
17	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.92280124
18	NANOG_20526341_ChIP-Seq_ESCs_Human	1.85002060
19	CTCF_27219007_Chip-Seq_Bcells_Human	1.81396828
20	RAC3_21632823_ChIP-Seq_H3396_Human	1.78118777
21	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.77410609
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77073818
23	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.75350816
24	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.75267308
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72698952
26	BCL6_27268052_Chip-Seq_Bcells_Human	1.71875063
27	E2F1_20622854_ChIP-Seq_HELA_Human	1.65230494
28	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.64849179
29	FUS_26573619_Chip-Seq_HEK293_Human	1.63521961
30	TAF2_19829295_ChIP-Seq_ESCs_Human	1.60342263
31	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.59200578
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58672429
33	SMC4_20622854_ChIP-Seq_HELA_Human	1.57759809
34	PHF8_20622854_ChIP-Seq_HELA_Human	1.57159615
35	BCOR_27268052_Chip-Seq_Bcells_Human	1.56348105
36	P68_20966046_ChIP-Seq_HELA_Human	1.52642989
37	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.51653217
38	MYC_19829295_ChIP-Seq_ESCs_Human	1.51258235
39	OCT4_20526341_ChIP-Seq_ESCs_Human	1.49941229
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.49860338
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.47802161
42	CTCF_20526341_ChIP-Seq_ESCs_Human	1.46957881
43	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.45399927
44	AR_25329375_ChIP-Seq_VCAP_Human	1.44715154
45	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.43407912
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.42734284
47	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.41724918
48	P300_27268052_Chip-Seq_Bcells_Human	1.40592847
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40146920
50	TP63_22573176_ChIP-Seq_HFKS_Human	1.39571380
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39025727
52	LXR_22292898_ChIP-Seq_THP-1_Human	1.36342540
53	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.35478997
54	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.31753524
55	ERG_20517297_ChIP-Seq_VCAP_Human	1.30951805
56	TAF15_26573619_Chip-Seq_HEK293_Human	1.29995205
57	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.28387075
58	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.28179404
59	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.27581535
60	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.26870088
61	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.25209509
62	RBPJ_21746931_ChIP-Seq_IB4_Human	1.24798083
63	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.24684760
64	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.24132703
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24052059
66	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.22921699
67	TP53_18474530_ChIP-ChIP_U2OS_Human	1.22566963
68	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.22557404
69	P53_21459846_ChIP-Seq_SAOS-2_Human	1.20892183
70	CEBPB_22108803_ChIP-Seq_LS180_Human	1.20526559
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20401129
72	ETV1_20927104_ChIP-Seq_GIST48_Human	1.19957795
73	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.18783833
74	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.17059695
75	SMRT_27268052_Chip-Seq_Bcells_Human	1.17041251
76	P300_19829295_ChIP-Seq_ESCs_Human	1.16881866
77	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.16403191
78	ZNF274_21170338_ChIP-Seq_K562_Hela	1.15836787
79	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.13264760
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12721254
81	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.10216468
82	NFYB_21822215_ChIP-Seq_K562_Human	1.10205894
83	SA1_27219007_Chip-Seq_Bcells_Human	1.10093468
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07737190
85	TBL1_22424771_ChIP-Seq_293T_Human	1.07347513
86	AR_21572438_ChIP-Seq_LNCaP_Human	1.07070993
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05159048
88	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.04743061
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04617161
90	RUNX_20019798_ChIP-Seq_JUKART_Human	1.04604479
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03466569
92	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01595950
93	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01372776
94	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01372776
95	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.01002219
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.00282533
97	PHF8_20622853_ChIP-Seq_HELA_Human	1.00226965
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99309514
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98851646
100	SMAD4_21799915_ChIP-Seq_A2780_Human	0.98339705

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	4.93111966
2	MP0005377_hearing/vestibular/ear_phenot	4.78068003
3	MP0003878_abnormal_ear_physiology	4.78068003
4	MP0003698_abnormal_male_reproductive	4.47287226
5	MP0001929_abnormal_gametogenesis	3.83549540
6	MP0001348_abnormal_lacrimal_gland	3.17046784
7	MP0000678_abnormal_parathyroid_gland	2.63781044
8	MP0002161_abnormal_fertility/fecundity	2.54343856
9	MP0003718_maternal_effect	2.16724027
10	MP0002822_catalepsy	2.05106358
11	MP0005410_abnormal_fertilization	12.3856285
12	MP0002234_abnormal_pharynx_morphology	1.98778433
13	MP0003646_muscle_fatigue	1.94119696
14	MP0002132_abnormal_respiratory_system	1.87700198
15	MP0005423_abnormal_somatic_nervous	1.85379035
16	MP0003011_delayed_dark_adaptation	1.84639734
17	MP0002210_abnormal_sex_determination	1.70797412
18	MP0002249_abnormal_larynx_morphology	1.66792517
19	MP0005379_endocrine/exocrine_gland_phen	1.57795617
20	MP0001485_abnormal_pinna_reflex	1.46507719
21	MP0002735_abnormal_chemical_nociception	1.46169354
22	MP0001145_abnormal_male_reproductive	1.41735972
23	MP0001486_abnormal_startle_reflex	1.39715874
24	MP0002282_abnormal_trachea_morphology	1.37714935
25	MP0000653_abnormal_sex_gland	1.36631027
26	MP0004859_abnormal_synaptic_plasticity	1.35885054
27	MP0009053_abnormal_anal_canal	1.33721520
28	MP0001968_abnormal_touch/_nociception	1.29522112
29	MP0000534_abnormal_ureter_morphology	1.29444516
30	MP0005310_abnormal_salivary_gland	1.29264598
31	MP0001765_abnormal_ion_homeostasis	1.12702675
32	MP0004742_abnormal_vestibular_system	1.09233741
33	MP0002127_abnormal_cardiovascular_syste	1.07859361
34	MP0004510_myositis	1.06848904
35	MP0001963_abnormal_hearing_physiology	1.04329446
36	MP0002138_abnormal_hepatobiliary_system	1.03745284
37	MP0000955_abnormal_spinal_cord	1.01091926
38	MP0005395_other_phenotype	0.98364897
39	MP0000026_abnormal_inner_ear	0.97238893
40	MP0000681_abnormal_thyroid_gland	0.95848590
41	MP0002229_neurodegeneration	0.94980551
42	MP0008569_lethality_at_weaning	0.91214291
43	MP0001905_abnormal_dopamine_level	0.91118074
44	MP0008877_abnormal_DNA_methylation	0.91038812
45	MP0003879_abnormal_hair_cell	0.88363785
46	MP0005551_abnormal_eye_electrophysiolog	0.87409714
47	MP0002067_abnormal_sensory_capabilities	0.85644347
48	MP0005248_abnormal_Harderian_gland	0.85303272
49	MP0002557_abnormal_social/conspecific_i	0.83623773
50	MP0000049_abnormal_middle_ear	0.81998056
51	MP0002733_abnormal_thermal_nociception	0.79998536
52	MP0009115_abnormal_fat_cell	0.77273649
53	MP0003880_abnormal_central_pattern	0.76367255
54	MP0005367_renal/urinary_system_phenotyp	0.76181271
55	MP0000516_abnormal_urinary_system	0.76181271
56	MP0009745_abnormal_behavioral_response	0.71906566
57	MP0005666_abnormal_adipose_tissue	0.71851460
58	MP0004085_abnormal_heartbeat	0.71821421
59	MP0001879_abnormal_lymphatic_vessel	0.71721644
60	MP0005451_abnormal_body_composition	0.70952721
61	MP0002272_abnormal_nervous_system	0.69961511
62	MP0006292_abnormal_olfactory_placode	0.69345868
63	MP0002572_abnormal_emotion/affect_behav	0.67149781
64	MP0005083_abnormal_biliary_tract	0.65351666
65	MP0002734_abnormal_mechanical_nocicepti	0.63311658
66	MP0004484_altered_response_of	0.62416262
67	MP0005375_adipose_tissue_phenotype	0.62050922
68	MP0005253_abnormal_eye_physiology	0.61821950
69	MP0001440_abnormal_grooming_behavior	0.61422625
70	MP0005636_abnormal_mineral_homeostasis	0.61237751
71	MP0003119_abnormal_digestive_system	0.61022076
72	MP0001970_abnormal_pain_threshold	0.59460406
73	MP0005167_abnormal_blood-brain_barrier	0.58136077
74	MP0000613_abnormal_salivary_gland	0.57682014
75	MP0001666_abnormal_nutrient_absorption	0.55605516
76	MP0003635_abnormal_synaptic_transmissio	0.52780732
77	MP0008995_early_reproductive_senescence	0.50416956
78	MP0000003_abnormal_adipose_tissue	0.50166210
79	MP0003699_abnormal_female_reproductive	0.49973881
80	MP0001501_abnormal_sleep_pattern	0.49280143
81	MP0002928_abnormal_bile_duct	0.48590400
82	MP0005535_abnormal_body_temperature	0.47619602
83	MP0003137_abnormal_impulse_conducting	0.47504703
84	MP0008961_abnormal_basal_metabolism	0.45642920
85	MP0005647_abnormal_sex_gland	0.45573313
86	MP0000470_abnormal_stomach_morphology	0.45137081
87	MP0000249_abnormal_blood_vessel	0.43617848
88	MP0009046_muscle_twitch	0.42802528
89	MP0002882_abnormal_neuron_morphology	0.41511831
90	MP0003077_abnormal_cell_cycle	0.41098993
91	MP0003631_nervous_system_phenotype	0.38948676
92	MP0009697_abnormal_copulation	0.38793156
93	MP0002653_abnormal_ependyma_morphology	0.37722150
94	MP0003936_abnormal_reproductive_system	0.37481611
95	MP0001270_distended_abdomen	0.37455617
96	MP0005084_abnormal_gallbladder_morpholo	0.36480395
97	MP0006276_abnormal_autonomic_nervous	0.36201378
98	MP0003861_abnormal_nervous_system	0.31421824
99	MP0002752_abnormal_somatic_nervous	0.30745591
100	MP0003632_abnormal_nervous_system	0.30505630

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.39738577
2	Absent/shortened dynein arms (HP:0200106)	5.68261809
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.68261809
4	Attenuation of retinal blood vessels (HP:0007843)	5.28948703
5	Bony spicule pigmentary retinopathy (HP:0007737)	5.23717198
6	Asymmetric septal hypertrophy (HP:0001670)	4.85704783
7	Bell-shaped thorax (HP:0001591)	4.60370697
8	Hyperkalemia (HP:0002153)	4.58830583
9	Tubulointerstitial nephritis (HP:0001970)	4.51140389
10	Abnormal ciliary motility (HP:0012262)	4.42773250
11	Resting tremor (HP:0002322)	4.34784384
12	Abnormal rod and cone electroretinograms (HP:0008323)	4.32838319
13	Abnormal respiratory motile cilium morphology (HP:0005938)	4.29574982
14	Abnormal respiratory epithelium morphology (HP:0012253)	4.29574982
15	Abnormal respiratory motile cilium physiology (HP:0012261)	4.27756495
16	Potter facies (HP:0002009)	4.24005021
17	Facial shape deformation (HP:0011334)	4.24005021
18	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.21995424
19	Chronic hepatic failure (HP:0100626)	4.18082497
20	Infertility (HP:0000789)	4.13685039
21	Hypoplastic ischia (HP:0003175)	4.13624162
22	Abnormality of macular pigmentation (HP:0008002)	4.10179447
23	Male infertility (HP:0003251)	3.99775038
24	Nasal polyposis (HP:0100582)	3.75765119
25	Abnormality of the ischium (HP:0003174)	3.65786681
26	Azoospermia (HP:0000027)	3.51503099
27	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.51218368
28	Enlarged epiphyses (HP:0010580)	3.49773604
29	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.44775158
30	Impulsivity (HP:0100710)	3.43696333
31	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.41196612
32	Abnormal spermatogenesis (HP:0008669)	3.37184158
33	Cone-rod dystrophy (HP:0000548)	3.33895322
34	Unilateral renal agenesis (HP:0000122)	3.28097382
35	Congenital malformation of the right heart (HP:0011723)	3.23700511
36	Double outlet right ventricle (HP:0001719)	3.23700511
37	Hypoplasia of the thymus (HP:0000778)	3.09057513
38	Abnormality of the aortic arch (HP:0012303)	3.08123982
39	Postural instability (HP:0002172)	3.06087686
40	Abnormality of the nasal mucosa (HP:0000433)	3.00660539
41	Abnormal urine output (HP:0012590)	2.98325531
42	Nephronophthisis (HP:0000090)	2.94937290
43	Renal dysplasia (HP:0000110)	2.88341159
44	Progressive cerebellar ataxia (HP:0002073)	2.73106347
45	Generalized aminoaciduria (HP:0002909)	2.72833785
46	Abnormality of potassium homeostasis (HP:0011042)	2.70514648
47	Rhinitis (HP:0012384)	2.61059788
48	Abnormality of the parathyroid morphology (HP:0011766)	2.60274976
49	Progressive sensorineural hearing impairment (HP:0000408)	2.57109472
50	Truncal obesity (HP:0001956)	2.56249079
51	Abnormality of renal excretion (HP:0011036)	2.56048135
52	Abnormal drinking behavior (HP:0030082)	2.51606539
53	Polydipsia (HP:0001959)	2.51606539
54	Epiphyseal dysplasia (HP:0002656)	2.50755813
55	Abnormality of the renal medulla (HP:0100957)	2.48724998
56	Hypoalphalipoproteinemia (HP:0003233)	2.48319088
57	Amelogenesis imperfecta (HP:0000705)	2.41459345
58	Polyuria (HP:0000103)	2.40011814
59	Abnormality of the costochondral junction (HP:0000919)	2.34224882
60	Stage 5 chronic kidney disease (HP:0003774)	2.32811157
61	Tubulointerstitial abnormality (HP:0001969)	2.29677793
62	Tetany (HP:0001281)	2.25797500
63	Abnormality of the pubic bones (HP:0003172)	2.23712665
64	Portal hypertension (HP:0001409)	2.20906085
65	Renovascular hypertension (HP:0100817)	2.20057395
66	Absent epiphyses (HP:0010577)	2.18958844
67	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.18958844
68	Insulin-resistant diabetes mellitus (HP:0000831)	2.18234255
69	Abnormality of dental color (HP:0011073)	2.11305835
70	Myokymia (HP:0002411)	2.06292716
71	Ventricular tachycardia (HP:0004756)	2.06038576
72	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.02884431
73	Widely patent fontanelles and sutures (HP:0004492)	2.02460450
74	Hypophosphatemic rickets (HP:0004912)	2.01220030
75	Decreased central vision (HP:0007663)	2.00566246
76	Menstrual irregularities (HP:0000858)	2.00400851
77	Abnormality of the hepatic vasculature (HP:0006707)	2.00215074
78	Flattened epiphyses (HP:0003071)	1.99808719
79	Hyponatremia (HP:0002902)	1.98908106
80	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.97665445
81	Hyperthyroidism (HP:0000836)	1.96848735
82	Amblyopia (HP:0000646)	1.96781596
83	Osteomalacia (HP:0002749)	1.94815819
84	Bronchiectasis (HP:0002110)	1.94048211
85	Transposition of the great arteries (HP:0001669)	1.93939174
86	Abnormal connection of the cardiac segments (HP:0011545)	1.93939174
87	Abnormal ventriculo-arterial connection (HP:0011563)	1.93939174
88	Abnormality of femoral epiphyses (HP:0006499)	1.88182957
89	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.88182957
90	Optic nerve hypoplasia (HP:0000609)	1.85387405
91	Recurrent pneumonia (HP:0006532)	1.83960485
92	Spastic paraparesis (HP:0002313)	1.81862267
93	Short ribs (HP:0000773)	1.81674917
94	Abnormality of the femoral head (HP:0003368)	1.81610324
95	Recurrent corneal erosions (HP:0000495)	1.79858732
96	Renal Fanconi syndrome (HP:0001994)	1.79315218
97	Abnormality of chloride homeostasis (HP:0011422)	1.78577269
98	Bulbous nose (HP:0000414)	1.76643923
99	Flat capital femoral epiphysis (HP:0003370)	1.76067373
100	Chronic bronchitis (HP:0004469)	1.75094911

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.62678716
2	TESK1	6.89189860
3	DDR2	5.21840972
4	STK38	3.68842568
5	MAP4K2	3.32152843
6	INSRR	3.21361479
7	PNCK	2.97525717
8	MAPK15	2.83523453
9	PLK2	2.80282577
10	STK38L	2.50230919
11	PRKD3	2.45793457
12	CAMK1G	2.37819766
13	BRD4	2.31669217
14	MST1R	1.78356824
15	WNK1	1.62518550
16	PDPK1	1.61281063
17	PDK1	1.48574262
18	DYRK1B	1.47960529
19	CDK7	1.32972156
20	PTK2B	1.17931715
21	NEK6	1.13247024
22	CDK12	1.13047370
23	PIK3CG	1.11432072
24	WNK4	1.05635336
25	SIK2	0.98564743
26	AKT3	0.97828756
27	KSR2	0.96024476
28	CAMK1D	0.94539744
29	MAP3K9	0.92461712
30	UHMK1	0.84564379
31	STK39	0.81333225
32	BMPR1B	0.75239805
33	RPS6KA2	0.73717260
34	PRKG1	0.69439962
35	MAP3K11	0.69245828
36	BRAF	0.67748052
37	MAP2K2	0.67406374
38	RPS6KA1	0.67186625
39	PRKG2	0.66424330
40	MARK1	0.65251184
41	PRKAA2	0.64256700
42	FRK	0.61272219
43	MAP3K2	0.58852250
44	ROCK1	0.58155597
45	LATS2	0.56872716
46	CAMK1	0.56274258
47	SGK223	0.52009699
48	SGK494	0.52009699
49	GSK3B	0.51390864
50	RIPK4	0.50725197
51	MAP3K4	0.50011820
52	MAP3K8	0.48608442
53	CDK2	0.48357620
54	CDK3	0.45901975
55	CDK4	0.45218379
56	LATS1	0.43592805
57	MAPK8	0.43337718
58	CDK1	0.42990367
59	PRKCG	0.42378302
60	MAPK1	0.41233879
61	NTRK3	0.41152993
62	ACVR1B	0.40613235
63	RPS6KA6	0.39745377
64	RPS6KC1	0.38549360
65	RPS6KL1	0.38549360
66	TESK2	0.37969003
67	PRKCZ	0.37948209
68	CAMK4	0.37666544
69	MTOR	0.36367505
70	MUSK	0.34188268
71	SGK1	0.33491468
72	TYRO3	0.29488149
73	OXSR1	0.29310439
74	CHEK1	0.28275938
75	PRKCB	0.27270953
76	MAPK14	0.27115152
77	MAP3K1	0.26237154
78	MINK1	0.26014574
79	FER	0.25760478
80	TNIK	0.25398646
81	ADRBK2	0.25194413
82	ZAK	0.23675038
83	MARK2	0.22945698
84	ARAF	0.21010369
85	MAPK10	0.20777467
86	PKN1	0.19765142
87	MAPK11	0.18075920
88	MET	0.17711461
89	DYRK2	0.17591453
90	AKT1	0.17383463
91	MAP2K7	0.16568589
92	PRKAA1	0.15899242
93	PRKCE	0.15830691
94	DYRK3	0.13696764
95	MAPK13	0.12815125
96	PRKACA	0.12766916
97	PINK1	0.12130948
98	PRKACB	0.10540290
99	SGK2	0.10528523
100	CAMK2A	0.08784605

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	8.01965400
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.55416430
3	Olfactory transduction_Homo sapiens_hsa04740	3.44204688
4	Butanoate metabolism_Homo sapiens_hsa00650	2.83034664
5	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.08792584
6	Taste transduction_Homo sapiens_hsa04742	1.83122224
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.77742037
8	Fatty acid degradation_Homo sapiens_hsa00071	1.75416842
9	Type I diabetes mellitus_Homo sapiens_hsa04940	1.62001931
10	Fatty acid metabolism_Homo sapiens_hsa01212	1.61683267
11	Type II diabetes mellitus_Homo sapiens_hsa04930	1.61019092
12	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.58687093
13	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.57893793
14	Allograft rejection_Homo sapiens_hsa05330	1.50962945
15	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.46298635
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.46029276
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.40650512
18	Phototransduction_Homo sapiens_hsa04744	1.38912010
19	Phenylalanine metabolism_Homo sapiens_hsa00360	1.35501768
20	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.27676564
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.27002567
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.24154344
23	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.22939595
24	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.17947142
25	Morphine addiction_Homo sapiens_hsa05032	1.17289241
26	RNA transport_Homo sapiens_hsa03013	1.14391853
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10385793
28	Endocytosis_Homo sapiens_hsa04144	1.08565986
29	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.08008199
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.07769694
31	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.06489818
32	Salivary secretion_Homo sapiens_hsa04970	1.05193245
33	Nicotine addiction_Homo sapiens_hsa05033	1.01395722
34	Circadian entrainment_Homo sapiens_hsa04713	0.98328242
35	Viral myocarditis_Homo sapiens_hsa05416	0.95477305
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95285424
37	Protein digestion and absorption_Homo sapiens_hsa04974	0.92887977
38	PPAR signaling pathway_Homo sapiens_hsa03320	0.91902135
39	Calcium signaling pathway_Homo sapiens_hsa04020	0.89854628
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89747564
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.87021833
42	cAMP signaling pathway_Homo sapiens_hsa04024	0.86212734
43	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.83865624
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.80174373
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80046659
46	ABC transporters_Homo sapiens_hsa02010	0.79564007
47	Arginine biosynthesis_Homo sapiens_hsa00220	0.79490731
48	Renin-angiotensin system_Homo sapiens_hsa04614	0.76861088
49	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.74530605
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.73693158
51	Oocyte meiosis_Homo sapiens_hsa04114	0.72768925
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.69728799
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.68524546
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68212300
55	Estrogen signaling pathway_Homo sapiens_hsa04915	0.66598072
56	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64451200
57	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.62297377
58	Insulin secretion_Homo sapiens_hsa04911	0.61351723
59	Tyrosine metabolism_Homo sapiens_hsa00350	0.60242483
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60166558
61	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.58575801
62	Gastric acid secretion_Homo sapiens_hsa04971	0.58344944
63	Purine metabolism_Homo sapiens_hsa00230	0.55393172
64	GABAergic synapse_Homo sapiens_hsa04727	0.55252279
65	Influenza A_Homo sapiens_hsa05164	0.52445112
66	Retinol metabolism_Homo sapiens_hsa00830	0.52346409
67	Tight junction_Homo sapiens_hsa04530	0.52201572
68	Cholinergic synapse_Homo sapiens_hsa04725	0.52016627
69	Serotonergic synapse_Homo sapiens_hsa04726	0.51440151
70	Renin secretion_Homo sapiens_hsa04924	0.50220210
71	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.48991049
72	MAPK signaling pathway_Homo sapiens_hsa04010	0.48617096
73	Basal transcription factors_Homo sapiens_hsa03022	0.48203665
74	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.48103217
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.47107898
76	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.46546340
77	Bile secretion_Homo sapiens_hsa04976	0.44021580
78	Acute myeloid leukemia_Homo sapiens_hsa05221	0.33614466
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.32630316
80	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.31817520
81	Linoleic acid metabolism_Homo sapiens_hsa00591	0.29539826
82	VEGF signaling pathway_Homo sapiens_hsa04370	0.28891582
83	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.27096167
84	Pancreatic secretion_Homo sapiens_hsa04972	0.27009443
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.22972308
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.21901553
87	Prolactin signaling pathway_Homo sapiens_hsa04917	0.21108620
88	Viral carcinogenesis_Homo sapiens_hsa05203	0.21002318
89	Huntingtons disease_Homo sapiens_hsa05016	0.20283167
90	Fanconi anemia pathway_Homo sapiens_hsa03460	0.17645354
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.17412886
92	Cocaine addiction_Homo sapiens_hsa05030	0.17371823
93	Alcoholism_Homo sapiens_hsa05034	0.16934686
94	Peroxisome_Homo sapiens_hsa04146	0.16894772
95	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.16682428
96	Metabolic pathways_Homo sapiens_hsa01100	0.16548119
97	mRNA surveillance pathway_Homo sapiens_hsa03015	0.15244682
98	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.15130124
99	Circadian rhythm_Homo sapiens_hsa04710	0.12115675
100	Amphetamine addiction_Homo sapiens_hsa05031	0.11517127

GOLGA6L7P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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