ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	5.91527946
2	cilium or flagellum-dependent cell motility (GO:0001539)	5.62821241
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.57909472
4	epithelial cilium movement (GO:0003351)	4.79375068
5	cilium movement (GO:0003341)	4.69109808
6	centriole replication (GO:0007099)	4.36333312
7	sperm motility (GO:0030317)	4.21348699
8	regulation of cilium movement (GO:0003352)	4.08834458
9	establishment of protein localization to Golgi (GO:0072600)	3.99971503
10	motile cilium assembly (GO:0044458)	3.99230143
11	response to pheromone (GO:0019236)	3.98811740
12	acrosome reaction (GO:0007340)	3.95614201
13	microtubule depolymerization (GO:0007019)	3.89106653
14	protein targeting to Golgi (GO:0000042)	3.74526931
15	spermatid nucleus differentiation (GO:0007289)	3.70564210
16	microtubule polymerization or depolymerization (GO:0031109)	3.57845400
17	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.57349037
18	single strand break repair (GO:0000012)	3.51902268
19	centriole assembly (GO:0098534)	3.50599396
20	axoneme assembly (GO:0035082)	3.50456953
21	chromosome condensation (GO:0030261)	3.44410075
22	meiotic chromosome segregation (GO:0045132)	3.42587115
23	spermatid development (GO:0007286)	3.36641438
24	DNA packaging (GO:0006323)	3.36502318
25	microtubule severing (GO:0051013)	3.33676036
26	protein localization to Golgi apparatus (GO:0034067)	3.31891010
27	fusion of sperm to egg plasma membrane (GO:0007342)	3.22857268
28	regulation of centriole replication (GO:0046599)	3.19963041
29	cilium organization (GO:0044782)	3.16304681
30	cilium assembly (GO:0042384)	3.15804218
31	nonmotile primary cilium assembly (GO:0035058)	3.12418078
32	protein polyglutamylation (GO:0018095)	3.09023545
33	synapsis (GO:0007129)	3.07704073
34	photoreceptor cell maintenance (GO:0045494)	3.05833267
35	interkinetic nuclear migration (GO:0022027)	3.05696846
36	presynaptic membrane assembly (GO:0097105)	3.01086004
37	ventricular system development (GO:0021591)	2.94649448
38	regulation of meiosis I (GO:0060631)	2.85485250
39	intraciliary transport (GO:0042073)	2.84039425
40	peptidyl-threonine dephosphorylation (GO:0035970)	2.82016668
41	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.80839720
42	sperm-egg recognition (GO:0035036)	2.80260268
43	head development (GO:0060322)	2.79969484
44	one-carbon compound transport (GO:0019755)	2.79327313
45	histone H3-K9 demethylation (GO:0033169)	2.78047969
46	presynaptic membrane organization (GO:0097090)	2.74973367
47	phosphatidylethanolamine metabolic process (GO:0046337)	2.72549356
48	somite development (GO:0061053)	2.71547723
49	coenzyme catabolic process (GO:0009109)	2.71546077
50	inner ear receptor stereocilium organization (GO:0060122)	2.70938868
51	microtubule bundle formation (GO:0001578)	2.70575184
52	sperm capacitation (GO:0048240)	2.68380898
53	appendage development (GO:0048736)	2.66151300
54	limb development (GO:0060173)	2.66151300
55	regulation of microtubule-based movement (GO:0060632)	2.65598164
56	histone H3-K9 methylation (GO:0051567)	2.60888275
57	regulation of centrosome duplication (GO:0010824)	2.60088312
58	cellular component assembly involved in morphogenesis (GO:0010927)	2.58983918
59	left/right axis specification (GO:0070986)	2.58690205
60	acrosome assembly (GO:0001675)	2.58429004
61	limb bud formation (GO:0060174)	2.58007004
62	seminiferous tubule development (GO:0072520)	2.57844282
63	male gamete generation (GO:0048232)	2.57757081
64	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.56885961
65	spermatogenesis (GO:0007283)	2.56668861
66	DNA methylation involved in gamete generation (GO:0043046)	2.54890531
67	male meiosis (GO:0007140)	2.54530080
68	cilium morphogenesis (GO:0060271)	2.52406471
69	chromosome organization involved in meiosis (GO:0070192)	2.50003489
70	reciprocal meiotic recombination (GO:0007131)	2.47140115
71	reciprocal DNA recombination (GO:0035825)	2.47140115
72	embryonic foregut morphogenesis (GO:0048617)	2.46776086
73	plasma membrane fusion (GO:0045026)	2.46666479
74	cellular ketone body metabolic process (GO:0046950)	2.46316595
75	auditory receptor cell stereocilium organization (GO:0060088)	2.44423416
76	binding of sperm to zona pellucida (GO:0007339)	2.43919061
77	monoubiquitinated protein deubiquitination (GO:0035520)	2.43602088
78	gamete generation (GO:0007276)	2.41870310
79	positive regulation of Rab GTPase activity (GO:0032851)	2.39070932
80	regulation of Rab GTPase activity (GO:0032313)	2.39070932
81	DNA double-strand break processing (GO:0000729)	2.39039940
82	resolution of meiotic recombination intermediates (GO:0000712)	2.38964615
83	calcium ion-dependent exocytosis (GO:0017156)	2.35589338
84	Golgi to endosome transport (GO:0006895)	2.35450708
85	snRNA transcription (GO:0009301)	2.34350475
86	regulation of telomere maintenance (GO:0032204)	2.33674978
87	nucleosome disassembly (GO:0006337)	2.29120434
88	protein-DNA complex disassembly (GO:0032986)	2.29120434
89	microtubule-based movement (GO:0007018)	2.28614523
90	microtubule organizing center organization (GO:0031023)	2.28361949
91	regulation of collateral sprouting (GO:0048670)	2.28356414
92	apical protein localization (GO:0045176)	2.27132176
93	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.26640984
94	male meiosis I (GO:0007141)	2.25215876
95	protein localization to cilium (GO:0061512)	2.25170984
96	sister chromatid cohesion (GO:0007062)	2.23844587
97	multicellular organism reproduction (GO:0032504)	2.23631917
98	cerebral cortex radially oriented cell migration (GO:0021799)	2.23011403
99	regulation of centrosome cycle (GO:0046605)	2.22651722
100	spinal cord motor neuron differentiation (GO:0021522)	2.19514340

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.81751142
2	GBX2_23144817_ChIP-Seq_PC3_Human	2.93395159
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.79009511
4	TAF15_26573619_Chip-Seq_HEK293_Human	2.70597824
5	FUS_26573619_Chip-Seq_HEK293_Human	2.64609146
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.51314548
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.48745213
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.35785679
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.33006941
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.32089956
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.30220812
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.28109639
13	VDR_22108803_ChIP-Seq_LS180_Human	2.27478381
14	EWS_26573619_Chip-Seq_HEK293_Human	2.21884666
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.19093274
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.12612095
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10721442
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.10186697
19	P300_19829295_ChIP-Seq_ESCs_Human	1.93810629
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.92561619
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.92561619
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.91053755
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.87137532
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87137532
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.84291058
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.80023829
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78757483
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77834792
29	STAT3_23295773_ChIP-Seq_U87_Human	1.72983024
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71813197
31	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.64994629
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.61603292
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.60579825
34	TCF4_23295773_ChIP-Seq_U87_Human	1.58414121
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.56348225
36	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56072867
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55241255
38	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54838786
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.54086172
40	AR_25329375_ChIP-Seq_VCAP_Human	1.52061037
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.50541784
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48616560
43	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48241200
44	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.47895014
45	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45677795
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42131244
47	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41850539
48	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.39635459
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38558163
50	DROSHA_22980978_ChIP-Seq_HELA_Human	1.38533358
51	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38439585
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37000032
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30135877
54	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.29702868
55	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.29271525
56	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.25575005
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.22414132
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21812595
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.20155239
60	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.19632079
61	* WDR5_24793694_ChIP-Seq_LNCAP_Human	1.18108610
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17966932
63	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.17444567
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16647405
65	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.16308528
66	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.16139639
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16067979
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15675905
69	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.14960536
70	TBL1_22424771_ChIP-Seq_293T_Human	1.14373276
71	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.14021006
72	ETV1_20927104_ChIP-Seq_GIST48_Human	1.13628308
73	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.11448987
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11378188
75	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.10525729
76	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09881193
77	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.08847726
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05926622
79	NFYB_21822215_ChIP-Seq_K562_Human	1.05862195
80	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04101205
81	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.03744123
82	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.02977592
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00615497
84	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.00238517
85	SOX9_26525672_Chip-Seq_HEART_Mouse	1.00189085
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99600422
87	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99248899
88	AR_19668381_ChIP-Seq_PC3_Human	0.98753180
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.96288170
90	KDM2B_26808549_Chip-Seq_REH_Human	0.96286356
91	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.96171713
92	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.96072650
93	RXR_22108803_ChIP-Seq_LS180_Human	0.95449304
94	NFYA_21822215_ChIP-Seq_K562_Human	0.94199898
95	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.94014069
96	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.93464833
97	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.93425839
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93243947
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92766573
100	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92766573

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.05610766
2	MP0000566_synostosis	2.74096196
3	MP0006292_abnormal_olfactory_placode	2.64916879
4	MP0005377_hearing/vestibular/ear_phenot	2.16417827
5	MP0003878_abnormal_ear_physiology	2.16417827
6	MP0008877_abnormal_DNA_methylation	2.12689697
7	MP0003880_abnormal_central_pattern	2.10261626
8	MP0003698_abnormal_male_reproductive	2.03462156
9	MP0003122_maternal_imprinting	1.94242987
10	MP0002234_abnormal_pharynx_morphology	1.84058803
11	MP0001929_abnormal_gametogenesis	1.82435967
12	MP0003937_abnormal_limbs/digits/tail_de	1.81934276
13	MP0002249_abnormal_larynx_morphology	1.81354683
14	MP0004043_abnormal_pH_regulation	1.77253999
15	MP0000049_abnormal_middle_ear	1.66852819
16	MP0000383_abnormal_hair_follicle	1.65280984
17	MP0003890_abnormal_embryonic-extraembry	1.62359948
18	MP0001485_abnormal_pinna_reflex	1.61392995
19	MP0002102_abnormal_ear_morphology	1.58973406
20	MP0000778_abnormal_nervous_system	1.56997888
21	MP0000631_abnormal_neuroendocrine_gland	1.55280749
22	MP0003119_abnormal_digestive_system	1.52400144
23	MP0008995_early_reproductive_senescence	1.48243548
24	MP0001984_abnormal_olfaction	1.47173529
25	MP0004885_abnormal_endolymph	1.46848608
26	MP0004133_heterotaxia	1.46803436
27	MP0005499_abnormal_olfactory_system	1.46739621
28	MP0005394_taste/olfaction_phenotype	1.46739621
29	MP0008789_abnormal_olfactory_epithelium	1.45864588
30	MP0003121_genomic_imprinting	1.42451090
31	MP0005551_abnormal_eye_electrophysiolog	1.39757794
32	MP0004859_abnormal_synaptic_plasticity	1.39546229
33	MP0002210_abnormal_sex_determination	1.36842243
34	MP0002233_abnormal_nose_morphology	1.35124111
35	MP0001293_anophthalmia	1.32031497
36	MP0005646_abnormal_pituitary_gland	1.30729948
37	MP0005423_abnormal_somatic_nervous	1.29714117
38	MP0001486_abnormal_startle_reflex	1.29347749
39	MP0002653_abnormal_ependyma_morphology	1.26408139
40	MP0002735_abnormal_chemical_nociception	1.26258739
41	MP0003195_calcinosis	1.25798714
42	MP0004742_abnormal_vestibular_system	1.24648827
43	MP0000955_abnormal_spinal_cord	1.19894851
44	MP0003718_maternal_effect	1.19748234
45	MP0002938_white_spotting	1.19032916
46	MP0000427_abnormal_hair_cycle	1.18929901
47	MP0010678_abnormal_skin_adnexa	1.18241340
48	MP0003861_abnormal_nervous_system	1.17174711
49	MP0001145_abnormal_male_reproductive	1.16758684
50	MP0004147_increased_porphyrin_level	1.16018465
51	MP0003755_abnormal_palate_morphology	1.15400586
52	MP0002282_abnormal_trachea_morphology	1.14699988
53	MP0000026_abnormal_inner_ear	1.14534389
54	MP0001286_abnormal_eye_development	1.13839022
55	MP0000653_abnormal_sex_gland	1.12913186
56	MP0002184_abnormal_innervation	1.12549139
57	MP0003787_abnormal_imprinting	1.11926224
58	MP0005253_abnormal_eye_physiology	1.11537131
59	MP0006276_abnormal_autonomic_nervous	1.11304976
60	MP0000678_abnormal_parathyroid_gland	1.11147746
61	MP0002557_abnormal_social/conspecific_i	1.10221012
62	MP0002161_abnormal_fertility/fecundity	1.09418474
63	MP0003938_abnormal_ear_development	1.08109020
64	MP0001968_abnormal_touch/_nociception	1.06568667
65	MP0008058_abnormal_DNA_repair	1.05824467
66	MP0002822_catalepsy	1.04458774
67	MP0001529_abnormal_vocalization	1.03366299
68	MP0002928_abnormal_bile_duct	0.99019040
69	MP0009046_muscle_twitch	0.96800661
70	MP0003942_abnormal_urinary_system	0.96712903
71	MP0003567_abnormal_fetal_cardiomyocyte	0.95991190
72	MP0001963_abnormal_hearing_physiology	0.95814854
73	MP0003635_abnormal_synaptic_transmissio	0.94999499
74	MP0002752_abnormal_somatic_nervous	0.94523803
75	MP0001299_abnormal_eye_distance/	0.93367823
76	MP0005367_renal/urinary_system_phenotyp	0.92677894
77	MP0000516_abnormal_urinary_system	0.92677894
78	MP0002084_abnormal_developmental_patter	0.92012933
79	MP0009780_abnormal_chondrocyte_physiolo	0.91791482
80	MP0001188_hyperpigmentation	0.90782318
81	MP0002882_abnormal_neuron_morphology	0.89975097
82	MP0006072_abnormal_retinal_apoptosis	0.89610164
83	MP0002009_preneoplasia	0.88885985
84	MP0002736_abnormal_nociception_after	0.88706478
85	MP0003136_yellow_coat_color	0.88167271
86	MP0003935_abnormal_craniofacial_develop	0.88153210
87	MP0002697_abnormal_eye_size	0.87580575
88	MP0002734_abnormal_mechanical_nocicepti	0.87146890
89	MP0000579_abnormal_nail_morphology	0.86834092
90	MP0002272_abnormal_nervous_system	0.86756918
91	MP0003283_abnormal_digestive_organ	0.85606329
92	MP0002152_abnormal_brain_morphology	0.84793324
93	MP0003115_abnormal_respiratory_system	0.84594532
94	MP0009745_abnormal_behavioral_response	0.83981588
95	MP0002063_abnormal_learning/memory/cond	0.83471176
96	MP0005248_abnormal_Harderian_gland	0.83128802
97	MP0002572_abnormal_emotion/affect_behav	0.82880719
98	MP0002067_abnormal_sensory_capabilities	0.82465895
99	MP0005391_vision/eye_phenotype	0.82019812
100	MP0002116_abnormal_craniofacial_bone	0.81956087

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	5.60177680
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.60177680
3	Abnormal respiratory motile cilium morphology (HP:0005938)	4.57669964
4	Abnormal respiratory epithelium morphology (HP:0012253)	4.57669964
5	Abnormal ciliary motility (HP:0012262)	4.53523717
6	Abnormal respiratory motile cilium physiology (HP:0012261)	4.42388510
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.34231142
8	Pancreatic fibrosis (HP:0100732)	3.45253970
9	True hermaphroditism (HP:0010459)	3.36444603
10	Nephronophthisis (HP:0000090)	3.23700720
11	Pancreatic cysts (HP:0001737)	3.19516736
12	Chronic hepatic failure (HP:0100626)	3.04525072
13	Rhinitis (HP:0012384)	3.00793234
14	Chronic bronchitis (HP:0004469)	2.89804868
15	Abnormality of the renal medulla (HP:0100957)	2.87180509
16	Cystic liver disease (HP:0006706)	2.78403235
17	Bony spicule pigmentary retinopathy (HP:0007737)	2.77935052
18	Tubulointerstitial nephritis (HP:0001970)	2.74965133
19	Postaxial foot polydactyly (HP:0001830)	2.63440575
20	Bile duct proliferation (HP:0001408)	2.58652553
21	Abnormal biliary tract physiology (HP:0012439)	2.58652553
22	Molar tooth sign on MRI (HP:0002419)	2.57884303
23	Abnormality of midbrain morphology (HP:0002418)	2.57884303
24	Abnormality of the aortic arch (HP:0012303)	2.57684982
25	Supernumerary spleens (HP:0009799)	2.34979914
26	Bronchiectasis (HP:0002110)	2.32560636
27	Medial flaring of the eyebrow (HP:0010747)	2.27132487
28	Attenuation of retinal blood vessels (HP:0007843)	2.27053565
29	Occipital encephalocele (HP:0002085)	2.25110245
30	Hypoplastic ischia (HP:0003175)	2.23887024
31	Gait imbalance (HP:0002141)	2.22245259
32	Abnormality of the ischium (HP:0003174)	2.18575727
33	Genital tract atresia (HP:0001827)	2.17486175
34	Tubular atrophy (HP:0000092)	2.15701923
35	Vaginal atresia (HP:0000148)	2.14194171
36	Poor coordination (HP:0002370)	2.13660166
37	Hyperkalemia (HP:0002153)	2.13138626
38	Congenital primary aphakia (HP:0007707)	2.12278657
39	Intestinal atresia (HP:0011100)	2.12134296
40	Abnormality of the labia minora (HP:0012880)	2.11255208
41	Abnormal rod and cone electroretinograms (HP:0008323)	2.10235623
42	Male infertility (HP:0003251)	2.07705707
43	Anencephaly (HP:0002323)	2.07302954
44	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.06152929
45	Progressive cerebellar ataxia (HP:0002073)	2.06033481
46	Infertility (HP:0000789)	2.05685914
47	Abnormality of macular pigmentation (HP:0008002)	1.95477978
48	Postaxial hand polydactyly (HP:0001162)	1.95435115
49	Abnormality of the renal cortex (HP:0011035)	1.95120628
50	Male pseudohermaphroditism (HP:0000037)	1.90245222
51	Nephrogenic diabetes insipidus (HP:0009806)	1.87815496
52	Genetic anticipation (HP:0003743)	1.87594967
53	Congenital hepatic fibrosis (HP:0002612)	1.87529215
54	Renal dysplasia (HP:0000110)	1.86493983
55	Volvulus (HP:0002580)	1.85597057
56	Sloping forehead (HP:0000340)	1.85170933
57	Sclerocornea (HP:0000647)	1.83948148
58	Median cleft lip (HP:0000161)	1.82457933
59	Preaxial hand polydactyly (HP:0001177)	1.82294296
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80846168
61	Aqueductal stenosis (HP:0002410)	1.78875549
62	Abnormal drinking behavior (HP:0030082)	1.78491634
63	Polydipsia (HP:0001959)	1.78491634
64	Decreased central vision (HP:0007663)	1.75737050
65	Drooling (HP:0002307)	1.74301512
66	Tubulointerstitial abnormality (HP:0001969)	1.72036531
67	Broad-based gait (HP:0002136)	1.71143684
68	Midline defect of the nose (HP:0004122)	1.70791705
69	Bell-shaped thorax (HP:0001591)	1.70403492
70	Preaxial foot polydactyly (HP:0001841)	1.69738827
71	Astigmatism (HP:0000483)	1.68460030
72	Multicystic kidney dysplasia (HP:0000003)	1.67518076
73	Gaze-evoked nystagmus (HP:0000640)	1.66145592
74	Hepatoblastoma (HP:0002884)	1.65228279
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.65030505
76	Abnormality of the pubic bones (HP:0003172)	1.64750843
77	Abnormal biliary tract morphology (HP:0012440)	1.63269616
78	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.63220493
79	Abnormality of the parathyroid morphology (HP:0011766)	1.62603010
80	Abnormality of the nasal septum (HP:0000419)	1.62278251
81	Meckel diverticulum (HP:0002245)	1.61642428
82	Abnormality of the ileum (HP:0001549)	1.61396680
83	Neoplasm of the oral cavity (HP:0100649)	1.61251370
84	Exotropia (HP:0000577)	1.58727015
85	Stage 5 chronic kidney disease (HP:0003774)	1.57114514
86	Dandy-Walker malformation (HP:0001305)	1.56536892
87	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.56374564
88	Cerebellar dysplasia (HP:0007033)	1.56211755
89	Gonadal dysgenesis (HP:0000133)	1.55813485
90	Cutaneous finger syndactyly (HP:0010554)	1.55617517
91	Optic nerve hypoplasia (HP:0000609)	1.55204207
92	Biliary tract neoplasm (HP:0100574)	1.53898219
93	Abnormal lung lobation (HP:0002101)	1.52459356
94	Protruding tongue (HP:0010808)	1.52352655
95	Renal hypoplasia (HP:0000089)	1.51956456
96	Anophthalmia (HP:0000528)	1.51301232
97	Febrile seizures (HP:0002373)	1.51006476
98	Potter facies (HP:0002009)	1.50431452
99	Facial shape deformation (HP:0011334)	1.50431452
100	Broad foot (HP:0001769)	1.49742244

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.48468114
2	PLK4	3.10342879
3	PNCK	2.58287310
4	MAP3K4	2.44821069
5	BCR	2.40958841
6	BMPR1B	2.39219126
7	CASK	2.32669752
8	ACVR1B	2.28418772
9	FGFR2	2.21145100
10	CAMK1G	1.97120807
11	NEK2	1.94589169
12	BRD4	1.91624480
13	MKNK2	1.88689950
14	LATS1	1.79207832
15	INSRR	1.76099344
16	WNK4	1.73159524
17	TNIK	1.70874921
18	MAP4K2	1.68684388
19	EPHA4	1.66524276
20	WNK3	1.63784097
21	MARK1	1.60843906
22	MAPK15	1.58997065
23	MAPK13	1.48601739
24	PLK2	1.38068449
25	STK38L	1.34376330
26	MAP3K9	1.31446055
27	CAMK1D	1.30356277
28	MKNK1	1.26597924
29	MAP2K7	1.25859727
30	NTRK3	1.24422969
31	NEK1	1.23911196
32	NUAK1	1.19724442
33	STK39	1.18160291
34	TTK	1.14234477
35	DYRK2	1.11076311
36	WNK1	1.04789785
37	WEE1	1.04703477
38	TRIM28	0.98339536
39	AKT3	0.97849643
40	NME1	0.96008806
41	PINK1	0.95561045
42	BRSK2	0.93613148
43	TAF1	0.93017194
44	DYRK3	0.89307820
45	OXSR1	0.87530377
46	SGK2	0.85949970
47	PKN2	0.85007758
48	PLK1	0.84521106
49	ERBB3	0.82801724
50	NTRK2	0.81149430
51	FGFR1	0.80109086
52	SGK223	0.79301602
53	SGK494	0.79301602
54	MAP3K7	0.79008825
55	PRKD3	0.77990806
56	CDK3	0.75580095
57	CDK19	0.75423085
58	GRK1	0.72944185
59	PASK	0.68624392
60	UHMK1	0.66256160
61	SGK1	0.65422414
62	PRKCE	0.64581467
63	SIK2	0.64147636
64	ATM	0.63594507
65	CDC7	0.62899426
66	MAP2K4	0.62113543
67	PRKCG	0.61895890
68	CHEK1	0.60498668
69	STK38	0.60129684
70	PRKAA1	0.58736433
71	STK3	0.58053274
72	FLT3	0.56974111
73	STK11	0.56249505
74	CDK1	0.56219337
75	DDR2	0.56215055
76	DYRK1A	0.55077365
77	CSNK1E	0.54406275
78	ATR	0.53079280
79	PLK3	0.52857389
80	MAP3K6	0.52701403
81	ERBB2	0.50916236
82	PRKAA2	0.49717842
83	TGFBR1	0.49552834
84	CDK12	0.48897779
85	FGFR3	0.48852212
86	ADRBK2	0.48634615
87	SRPK1	0.47510445
88	GSK3B	0.46909264
89	CHEK2	0.45863818
90	MET	0.44153977
91	PRKG1	0.43725297
92	FER	0.41754169
93	CDK2	0.41597747
94	CSNK1G2	0.41460434
95	TYRO3	0.40696871
96	MINK1	0.38338376
97	PHKG2	0.37739878
98	PHKG1	0.37739878
99	PRKDC	0.36550886
100	MAPK14	0.35533251

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.52015262
2	Propanoate metabolism_Homo sapiens_hsa00640	2.34996297
3	Nicotine addiction_Homo sapiens_hsa05033	2.30307787
4	Butanoate metabolism_Homo sapiens_hsa00650	2.19720285
5	Fanconi anemia pathway_Homo sapiens_hsa03460	1.95609464
6	Olfactory transduction_Homo sapiens_hsa04740	1.81842256
7	Taste transduction_Homo sapiens_hsa04742	1.78546918
8	Phototransduction_Homo sapiens_hsa04744	1.73913714
9	Linoleic acid metabolism_Homo sapiens_hsa00591	1.73783102
10	Steroid biosynthesis_Homo sapiens_hsa00100	1.70714340
11	Basal transcription factors_Homo sapiens_hsa03022	1.67802071
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.65626197
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.64905063
14	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.60609995
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53806006
16	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.50396049
17	ABC transporters_Homo sapiens_hsa02010	1.46414536
18	Lysine degradation_Homo sapiens_hsa00310	1.44096342
19	Homologous recombination_Homo sapiens_hsa03440	1.43333048
20	Caffeine metabolism_Homo sapiens_hsa00232	1.38241428
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35020284
22	mRNA surveillance pathway_Homo sapiens_hsa03015	1.33968348
23	Insulin secretion_Homo sapiens_hsa04911	1.33288723
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.32609530
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.32066831
26	RNA transport_Homo sapiens_hsa03013	1.31691668
27	Basal cell carcinoma_Homo sapiens_hsa05217	1.30910582
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.30766750
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29713707
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.26334280
31	Fatty acid degradation_Homo sapiens_hsa00071	1.21013470
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.19829377
33	Circadian entrainment_Homo sapiens_hsa04713	1.13759125
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.12636177
35	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.12485749
36	Oocyte meiosis_Homo sapiens_hsa04114	1.12285215
37	Regulation of autophagy_Homo sapiens_hsa04140	1.06737743
38	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.04359558
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.03426988
40	Morphine addiction_Homo sapiens_hsa05032	1.00574996
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99200626
42	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99140042
43	RNA degradation_Homo sapiens_hsa03018	0.97350135
44	Non-homologous end-joining_Homo sapiens_hsa03450	0.96048640
45	Type II diabetes mellitus_Homo sapiens_hsa04930	0.95756446
46	GABAergic synapse_Homo sapiens_hsa04727	0.95234968
47	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.93594948
48	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.93198071
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92491801
50	Hippo signaling pathway_Homo sapiens_hsa04390	0.91694802
51	Retinol metabolism_Homo sapiens_hsa00830	0.87895732
52	Salivary secretion_Homo sapiens_hsa04970	0.87890540
53	Axon guidance_Homo sapiens_hsa04360	0.85459720
54	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.85333174
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.84640601
56	Tight junction_Homo sapiens_hsa04530	0.84553828
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83321561
58	Serotonergic synapse_Homo sapiens_hsa04726	0.82901808
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.81807138
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80703565
61	Cell cycle_Homo sapiens_hsa04110	0.80603976
62	Wnt signaling pathway_Homo sapiens_hsa04310	0.80016333
63	Long-term depression_Homo sapiens_hsa04730	0.79400183
64	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.78004687
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.75071261
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73759519
67	Amphetamine addiction_Homo sapiens_hsa05031	0.73161965
68	Adherens junction_Homo sapiens_hsa04520	0.70387867
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70018765
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69253201
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.69097192
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.68148664
73	Cocaine addiction_Homo sapiens_hsa05030	0.67750296
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67421426
75	Circadian rhythm_Homo sapiens_hsa04710	0.67207789
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67179921
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.65544537
78	Renin secretion_Homo sapiens_hsa04924	0.63914037
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.63875068
80	Glucagon signaling pathway_Homo sapiens_hsa04922	0.60871660
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.60788177
82	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.59016334
83	Cholinergic synapse_Homo sapiens_hsa04725	0.57665608
84	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.56789719
85	Mismatch repair_Homo sapiens_hsa03430	0.56630022
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55422335
87	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.54819313
88	Protein digestion and absorption_Homo sapiens_hsa04974	0.52730153
89	Pancreatic secretion_Homo sapiens_hsa04972	0.52448940
90	One carbon pool by folate_Homo sapiens_hsa00670	0.51696422
91	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.51021098
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50686868
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.50116244
94	Choline metabolism in cancer_Homo sapiens_hsa05231	0.49942107
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49574696
96	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.48941648
97	Histidine metabolism_Homo sapiens_hsa00340	0.47599830
98	Tryptophan metabolism_Homo sapiens_hsa00380	0.47427054
99	Peroxisome_Homo sapiens_hsa04146	0.47364219
100	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.46421654

GOLGA6L9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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