GOLGA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)9.60250199
2ensheathment of neurons (GO:0007272)7.38943400
3axon ensheathment (GO:0008366)7.38943400
4myelination (GO:0042552)7.37005159
5cholesterol biosynthetic process (GO:0006695)7.13106235
6sterol biosynthetic process (GO:0016126)6.20994014
7long-chain fatty acid biosynthetic process (GO:0042759)6.13862488
8negative regulation of neurotransmitter secretion (GO:0046929)5.63219772
9isoprenoid biosynthetic process (GO:0008299)5.61098600
10myelin maintenance (GO:0043217)5.30187118
11amyloid precursor protein metabolic process (GO:0042982)5.03499974
12regulation of collateral sprouting (GO:0048670)5.00546817
13long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.87364178
14negative regulation of neurotransmitter transport (GO:0051589)4.65563789
15glycerophospholipid catabolic process (GO:0046475)4.40420875
16adhesion of symbiont to host cell (GO:0044650)4.38723870
17virion attachment to host cell (GO:0019062)4.38723870
18long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.35819116
19substantia nigra development (GO:0021762)4.34638283
20response to methylmercury (GO:0051597)4.31196144
21oligodendrocyte differentiation (GO:0048709)4.27263291
22cullin deneddylation (GO:0010388)4.25188440
23response to lipoprotein particle (GO:0055094)4.22745923
24response to redox state (GO:0051775)4.22263624
25fatty-acyl-CoA biosynthetic process (GO:0046949)4.20762023
26creatine metabolic process (GO:0006600)4.18067291
27positive regulation of actin filament depolymerization (GO:0030836)4.17733600
28photoreceptor cell differentiation (GO:0046530)4.15545929
29eye photoreceptor cell differentiation (GO:0001754)4.15545929
30astrocyte development (GO:0014002)4.13510610
31protein deneddylation (GO:0000338)4.04751627
32establishment of mitochondrion localization (GO:0051654)4.02230133
33positive regulation of oligodendrocyte differentiation (GO:0048714)3.98811376
34amyloid precursor protein catabolic process (GO:0042987)3.90046562
35nucleotide transmembrane transport (GO:1901679)3.85025823
36fatty-acyl-CoA metabolic process (GO:0035337)3.84032684
37DNA deamination (GO:0045006)3.83619909
38very long-chain fatty acid metabolic process (GO:0000038)3.75020785
39protein neddylation (GO:0045116)3.74954071
40platelet dense granule organization (GO:0060155)3.73139532
41L-amino acid import (GO:0043092)3.66281353
42asymmetric protein localization (GO:0008105)3.64807475
43negative regulation of protein localization to cell surface (GO:2000009)3.64013141
44apical protein localization (GO:0045176)3.62174864
45import into cell (GO:0098657)3.61020459
46myelination in peripheral nervous system (GO:0022011)3.60430215
47peripheral nervous system axon ensheathment (GO:0032292)3.60430215
48GPI anchor biosynthetic process (GO:0006506)3.59944152
49preassembly of GPI anchor in ER membrane (GO:0016254)3.59211373
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.54257659
51leukocyte migration involved in inflammatory response (GO:0002523)3.48227325
52glycosylceramide metabolic process (GO:0006677)3.47800438
53magnesium ion transport (GO:0015693)3.45474439
54interleukin-6-mediated signaling pathway (GO:0070102)3.41399081
55regulation of cellular amino acid metabolic process (GO:0006521)3.41030972
56GPI anchor metabolic process (GO:0006505)3.38505729
57regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.37763092
58mannosylation (GO:0097502)3.35702010
59proteasome assembly (GO:0043248)3.34884016
60thioester biosynthetic process (GO:0035384)3.33188132
61acyl-CoA biosynthetic process (GO:0071616)3.33188132
62metallo-sulfur cluster assembly (GO:0031163)3.32534317
63iron-sulfur cluster assembly (GO:0016226)3.32534317
64L-serine metabolic process (GO:0006563)3.31954262
65positive regulation of mitochondrial fission (GO:0090141)3.29796618
66positive regulation of pseudopodium assembly (GO:0031274)3.27882278
67adhesion of symbiont to host (GO:0044406)3.27486985
68Arp2/3 complex-mediated actin nucleation (GO:0034314)3.27038754
69anterograde synaptic vesicle transport (GO:0048490)3.22191626
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18861392
71regulation of lipoprotein metabolic process (GO:0050746)3.17803490
72axon development (GO:0061564)3.17468314
73negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.17108124
74positive regulation of cellular amine metabolic process (GO:0033240)3.16391095
75response to lead ion (GO:0010288)3.11445152
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.11141021
77regulation of regulatory T cell differentiation (GO:0045589)3.09617839
78mitotic nuclear envelope reassembly (GO:0007084)3.09555926
79nuclear envelope reassembly (GO:0031468)3.09555926
80cytidine metabolic process (GO:0046087)3.08394588
81cytidine catabolic process (GO:0006216)3.08394588
82cytidine deamination (GO:0009972)3.08394588
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07674792
84negative regulation of JUN kinase activity (GO:0043508)3.07238417
85negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.06919062
86signal peptide processing (GO:0006465)3.06294334
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03571091
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03571091
89limb bud formation (GO:0060174)3.03332437
90ear development (GO:0043583)3.02670163
91peripheral nervous system development (GO:0007422)3.01800290
92negative regulation of execution phase of apoptosis (GO:1900118)3.01159293
93sequestering of actin monomers (GO:0042989)3.01001211
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99812277
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99812277
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99812277
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99645167
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.98208601
99alcohol biosynthetic process (GO:0046165)2.97763490
100glial cell development (GO:0021782)2.97406459
101protein-cofactor linkage (GO:0018065)2.95839034
102Rap protein signal transduction (GO:0032486)2.95634869
103response to hepatocyte growth factor (GO:0035728)2.94073456
104cellular response to hepatocyte growth factor stimulus (GO:0035729)2.94073456
105regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91314859
106L-methionine salvage (GO:0071267)2.87917567
107L-methionine biosynthetic process (GO:0071265)2.87917567
108amino acid salvage (GO:0043102)2.87917567
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87915946
110negative regulation of ligase activity (GO:0051352)2.87915946
111antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86420572
112positive regulation of interleukin-8 secretion (GO:2000484)2.85781481
113peptidyl-tyrosine autophosphorylation (GO:0038083)2.85157205
114positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.84748260
115estrogen biosynthetic process (GO:0006703)2.84459045
116cholesterol metabolic process (GO:0008203)2.83678197
117heme transport (GO:0015886)2.82512394
118L-phenylalanine catabolic process (GO:0006559)2.82330882
119erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.82330882
120regulation of chronic inflammatory response (GO:0002676)2.81047071
121regulation of pseudopodium assembly (GO:0031272)2.80187932
122cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.78905810
123neural nucleus development (GO:0048857)2.78864968
124signal transduction involved in cell cycle checkpoint (GO:0072395)2.78660395
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.78223073
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78223073
127positive regulation of interleukin-17 production (GO:0032740)2.77771358
128negative regulation of axonogenesis (GO:0050771)2.77381022
129chaperone-mediated protein transport (GO:0072321)2.76184984
130membrane tubulation (GO:0097320)2.76176946
131membrane raft organization (GO:0031579)2.76059722
132positive regulation of gamma-delta T cell activation (GO:0046645)2.75435954
133purine-containing compound salvage (GO:0043101)2.75232612
134negative regulation of interleukin-17 production (GO:0032700)2.74120277
135leukocyte aggregation (GO:0070486)2.71903949
136steroid biosynthetic process (GO:0006694)2.71629401
137positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69835451
138pyrimidine ribonucleoside catabolic process (GO:0046133)2.69351098
139positive regulation of interleukin-1 beta secretion (GO:0050718)2.69215438
140activated T cell proliferation (GO:0050798)2.68531495
141anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67427137
142neutrophil activation involved in immune response (GO:0002283)2.67350904
143negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.67305045
144cerebral cortex radially oriented cell migration (GO:0021799)2.67132786
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66347503
146nucleotide transport (GO:0006862)2.66010216
147ATP hydrolysis coupled proton transport (GO:0015991)2.61295389
148energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61295389
149positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.60691105
150T cell migration (GO:0072678)2.59046266
151neutrophil activation (GO:0042119)2.57744930
152regulation of interleukin-1 beta secretion (GO:0050706)2.57019784
153actin nucleation (GO:0045010)2.56880141
154purine nucleotide salvage (GO:0032261)2.56377130
155positive regulation of ligase activity (GO:0051351)2.55814742
156positive regulation of interleukin-1 secretion (GO:0050716)2.53696408
157piRNA metabolic process (GO:0034587)2.53551167
158granulocyte activation (GO:0036230)2.53450635
159mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50559788
160eosinophil chemotaxis (GO:0048245)2.48771059
161regulation of cellular amine metabolic process (GO:0033238)2.48746690
162anterograde axon cargo transport (GO:0008089)2.43593956
163negative regulation of membrane potential (GO:0045837)2.43429442
164DNA double-strand break processing (GO:0000729)2.42809657
165exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.40624438
166immunoglobulin mediated immune response (GO:0016064)2.39312575
167viral protein processing (GO:0019082)2.39050081
168antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.38468764
169pyrimidine nucleobase catabolic process (GO:0006208)2.38063273
170regulation of B cell receptor signaling pathway (GO:0050855)2.36015396
171negative regulation of T cell apoptotic process (GO:0070233)2.35425919
172regulation of isotype switching to IgG isotypes (GO:0048302)2.34980598
173negative regulation of protein ubiquitination (GO:0031397)2.34893939
174intracellular protein transmembrane import (GO:0044743)2.34727376
175regulation of ubiquitin-protein transferase activity (GO:0051438)2.32780872
176negative regulation by host of viral transcription (GO:0043922)2.31927418
177de novo posttranslational protein folding (GO:0051084)2.31399628
178positive regulation of alpha-beta T cell proliferation (GO:0046641)2.29551990
179neurotransmitter uptake (GO:0001504)2.29458702
180DNA catabolic process, exonucleolytic (GO:0000738)2.29293504
181nucleoside salvage (GO:0043174)2.29030555
182phagosome maturation (GO:0090382)2.28769792
183de novo protein folding (GO:0006458)2.27738389
184establishment of protein localization to mitochondrial membrane (GO:0090151)2.27375150
185positive regulation of lamellipodium assembly (GO:0010592)2.26732379
186regulation of T cell tolerance induction (GO:0002664)2.25422361
187positive regulation of TOR signaling (GO:0032008)2.24896898
188RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.23285965
189tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.23285965
190eosinophil migration (GO:0072677)2.23262234
191regulation of ligase activity (GO:0051340)2.22588240
192protein refolding (GO:0042026)2.22556079
193DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.22176966
194axon ensheathment in central nervous system (GO:0032291)11.9517188
195central nervous system myelination (GO:0022010)11.9517188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.00872501
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.17342984
3SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse3.72493873
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79390199
5* VDR_23849224_ChIP-Seq_CD4+_Human2.68488717
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.63093257
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.62648323
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59419900
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58852815
10OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.58823196
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57996328
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57970188
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.57334948
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.56065702
15* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40362586
16IGF1R_20145208_ChIP-Seq_DFB_Human2.29088687
17ER_23166858_ChIP-Seq_MCF-7_Human2.22563275
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17337015
19TAF15_26573619_Chip-Seq_HEK293_Human2.16892426
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15874752
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.98426309
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.97903227
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94840059
24FOXP3_21729870_ChIP-Seq_TREG_Human1.88823937
25EOMES_21245162_ChIP-Seq_HESCs_Human1.81033848
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.77638794
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77407736
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.74322486
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.74322486
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72954067
31SOX17_20123909_ChIP-Seq_XEN_Mouse1.72642004
32PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.63887238
33VDR_22108803_ChIP-Seq_LS180_Human1.60942867
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60926552
35ZNF274_21170338_ChIP-Seq_K562_Hela1.60701017
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60270879
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59673207
38STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.52747598
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.52134149
40HTT_18923047_ChIP-ChIP_STHdh_Human1.51117755
41AR_21572438_ChIP-Seq_LNCaP_Human1.50817840
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50768027
43* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48995993
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47003847
45FUS_26573619_Chip-Seq_HEK293_Human1.46786742
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46239189
47GBX2_23144817_ChIP-Seq_PC3_Human1.46149147
48SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.45875054
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.45698448
50EWS_26573619_Chip-Seq_HEK293_Human1.45286469
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42843542
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.42764205
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41225745
54* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40749279
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40603578
56DCP1A_22483619_ChIP-Seq_HELA_Human1.39454013
57LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38090262
58MYB_26560356_Chip-Seq_TH2_Human1.38076531
59RUNX_20019798_ChIP-Seq_JUKART_Human1.37463592
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.36603231
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35491019
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.33505377
63GATA3_26560356_Chip-Seq_TH2_Human1.32322063
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29948813
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28526706
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26662581
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26546504
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25615475
69GABP_19822575_ChIP-Seq_HepG2_Human1.25044631
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.25014547
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24777103
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23299064
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22893801
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22839444
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22289761
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21167112
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19569998
78* SPI1_23547873_ChIP-Seq_NB4_Human1.19386946
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19337732
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.18923477
81* TAL1_26923725_Chip-Seq_HPCs_Mouse1.18524444
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.16585531
83SALL4_22934838_ChIP-ChIP_CD34+_Human1.16553630
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16499428
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.15849930
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.15634728
87* SOX2_19829295_ChIP-Seq_ESCs_Human1.13268702
88* NANOG_19829295_ChIP-Seq_ESCs_Human1.13268702
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13003323
90* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11880282
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11144241
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.10986454
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10215409
94* SRF_21415370_ChIP-Seq_HL-1_Mouse1.09606998
95* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09564501
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09224019
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07426428
98GATA3_27048872_Chip-Seq_THYMUS_Human1.06904179
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06153928
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05444436
101P300_18555785_Chip-Seq_ESCs_Mouse1.04650475
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04519497
103IRF1_19129219_ChIP-ChIP_H3396_Human1.03369792
104ETS1_20019798_ChIP-Seq_JURKAT_Human1.02516047
105MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02374970
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98289830
107ELK1_19687146_ChIP-ChIP_HELA_Human0.97372145
108THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97218888
109IRF8_27001747_Chip-Seq_BMDM_Mouse0.95901242
110FOXA1_25552417_ChIP-Seq_VCAP_Human0.95894533
111GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94935699
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94658062
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94523915
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94456064
115YY1_21170310_ChIP-Seq_MESCs_Mouse0.94076581
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93615088
117SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93241975
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93094603
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92268925
120* SMAD3_21741376_ChIP-Seq_EPCs_Human0.92190872
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92075446
122CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91470115
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91058176
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90265473
125TP53_22573176_ChIP-Seq_HFKS_Human0.90095234
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89419330
127TFEB_21752829_ChIP-Seq_HELA_Human0.89379182
128CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89096489
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88703648
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88037458
131HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87825287
132OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87369852
133REST_19997604_ChIP-ChIP_NEURONS_Mouse0.86995893
134P53_22387025_ChIP-Seq_ESCs_Mouse0.86774539
135* ELK1_22589737_ChIP-Seq_MCF10A_Human0.85726672
136* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84963150
137* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84676099
138MYC_18940864_ChIP-ChIP_HL60_Human0.84311799
139ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84202485
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83795696
141* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.83450141
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83137739
143PHF8_20622853_ChIP-Seq_HELA_Human0.82596084
144* SOX2_20726797_ChIP-Seq_SW620_Human0.82439727
145STAT3_18555785_Chip-Seq_ESCs_Mouse0.82142919
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81995633
147RUNX1_27457419_Chip-Seq_LIVER_Mouse0.80379159
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80281343
149KLF4_18555785_Chip-Seq_ESCs_Mouse0.79838007
150LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79576594
151* P300_19829295_ChIP-Seq_ESCs_Human0.79120178
152SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78919360
153E2F1_18555785_ChIP-Seq_MESCs_Mouse0.78485207
154GATA6_21074721_ChIP-Seq_CACO-2_Human0.78355522
155OCT4_20526341_ChIP-Seq_ESCs_Human0.78329969
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.78017225
157EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.75825148
158CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75698530
159SOX2_16153702_ChIP-ChIP_HESCs_Human0.75650459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination6.72718643
2MP0003950_abnormal_plasma_membrane4.38185476
3MP0003806_abnormal_nucleotide_metabolis3.91593993
4MP0003690_abnormal_glial_cell3.80986042
5MP0003724_increased_susceptibility_to3.44540631
6MP0005671_abnormal_response_to3.20189837
7MP0005171_absent_coat_pigmentation3.03571802
8MP0002102_abnormal_ear_morphology2.77946935
9MP0004134_abnormal_chest_morphology2.70377985
10MP0009785_altered_susceptibility_to2.66558893
11MP0001529_abnormal_vocalization2.56024165
12MP0003634_abnormal_glial_cell2.48874665
13MP0003136_yellow_coat_color2.48770508
14MP0005451_abnormal_body_composition2.48569759
15MP0003329_amyloid_beta_deposits2.47192589
16MP0001905_abnormal_dopamine_level2.44438498
17MP0008260_abnormal_autophagy2.42230614
18MP0004742_abnormal_vestibular_system2.38896632
19MP0004885_abnormal_endolymph2.38693209
20MP0005409_darkened_coat_color2.20777343
21MP0003632_abnormal_nervous_system2.16834056
22MP0001485_abnormal_pinna_reflex2.14779949
23MP0000566_synostosis2.10176589
24MP0008058_abnormal_DNA_repair2.03837147
25MP0001835_abnormal_antigen_presentation1.99341670
26MP0000383_abnormal_hair_follicle1.92497941
27MP0005408_hypopigmentation1.90555046
28MP0008877_abnormal_DNA_methylation1.90150230
29MP0003880_abnormal_central_pattern1.88434976
30MP0008057_abnormal_DNA_replication1.87160918
31MP0010678_abnormal_skin_adnexa1.86031928
32MP0003195_calcinosis1.83847661
33MP0005058_abnormal_lysosome_morphology1.79272020
34MP0004142_abnormal_muscle_tone1.78913620
35MP0004270_analgesia1.78495678
36MP0003656_abnormal_erythrocyte_physiolo1.77274716
37MP0009764_decreased_sensitivity_to1.77097959
38MP0008438_abnormal_cutaneous_collagen1.76198407
39MP0002638_abnormal_pupillary_reflex1.73452395
40MP0000462_abnormal_digestive_system1.69281880
41MP0006054_spinal_hemorrhage1.67475485
42MP0001800_abnormal_humoral_immune1.66292738
43MP0005084_abnormal_gallbladder_morpholo1.65950150
44MP0000778_abnormal_nervous_system1.65925149
45MP0008004_abnormal_stomach_pH1.65444440
46MP0002736_abnormal_nociception_after1.65254044
47MP0004381_abnormal_hair_follicle1.64417114
48MP0002723_abnormal_immune_serum1.61825925
49MP0000604_amyloidosis1.58880665
50MP0004147_increased_porphyrin_level1.57276719
51MP0002420_abnormal_adaptive_immunity1.56490072
52MP0005464_abnormal_platelet_physiology1.56064297
53MP0005167_abnormal_blood-brain_barrier1.56017937
54MP0002229_neurodegeneration1.54891003
55MP0001984_abnormal_olfaction1.52849236
56MP0003436_decreased_susceptibility_to1.52731497
57MP0001819_abnormal_immune_cell1.50659068
58MP0004859_abnormal_synaptic_plasticity1.50483035
59MP0006072_abnormal_retinal_apoptosis1.48655526
60MP0009745_abnormal_behavioral_response1.46941686
61MP0003011_delayed_dark_adaptation1.45179564
62MP0006082_CNS_inflammation1.44296467
63MP0005025_abnormal_response_to1.40127070
64MP0002272_abnormal_nervous_system1.38926147
65MP0002452_abnormal_antigen_presenting1.36429774
66MP0001501_abnormal_sleep_pattern1.35032624
67MP0001346_abnormal_lacrimal_gland1.31412860
68MP0006036_abnormal_mitochondrial_physio1.30537260
69MP0001661_extended_life_span1.30086955
70MP0001299_abnormal_eye_distance/1.29113615
71MP0005410_abnormal_fertilization1.28817908
72MP0000647_abnormal_sebaceous_gland1.27384055
73MP0003937_abnormal_limbs/digits/tail_de1.26693738
74MP0001853_heart_inflammation1.25462472
75MP0000343_altered_response_to1.24277876
76MP0002938_white_spotting1.24185829
77MP0003631_nervous_system_phenotype1.24057599
78MP0009697_abnormal_copulation1.23360645
79MP0000465_gastrointestinal_hemorrhage1.21572065
80MP0003075_altered_response_to1.21529169
81MP0003221_abnormal_cardiomyocyte_apopto1.19919614
82MP0002277_abnormal_respiratory_mucosa1.17915476
83MP0002398_abnormal_bone_marrow1.15574450
84MP0001851_eye_inflammation1.15325321
85MP0001968_abnormal_touch/_nociception1.14883366
86MP0006276_abnormal_autonomic_nervous1.14353700
87MP0001486_abnormal_startle_reflex1.14273300
88MP0002132_abnormal_respiratory_system1.13248801
89MP0003186_abnormal_redox_activity1.12682759
90MP0000716_abnormal_immune_system1.10390779
91MP0005387_immune_system_phenotype1.09217075
92MP0001790_abnormal_immune_system1.09217075
93MP0001177_atelectasis1.08914502
94MP0008932_abnormal_embryonic_tissue1.08698009
95MP0003448_altered_tumor_morphology1.07813748
96MP0002295_abnormal_pulmonary_circulatio1.06836435
97MP0010155_abnormal_intestine_physiology1.06818222
98MP0000689_abnormal_spleen_morphology1.05452900
99MP0002933_joint_inflammation1.05011694
100MP0003938_abnormal_ear_development1.04364698
101MP0009250_abnormal_appendicular_skeleto1.03291140
102MP0000372_irregular_coat_pigmentation1.01967276
103MP0001845_abnormal_inflammatory_respons1.01582272
104MP0005075_abnormal_melanosome_morpholog0.99985738
105MP0009763_increased_sensitivity_to0.99698076
106MP0002405_respiratory_system_inflammati0.99553892
107MP0009840_abnormal_foam_cell0.99374199
108MP0002722_abnormal_immune_system0.98891900
109MP0000955_abnormal_spinal_cord0.98560993
110MP0001542_abnormal_bone_strength0.97897314
111MP0003763_abnormal_thymus_physiology0.97828236
112MP0008873_increased_physiological_sensi0.97431129
113MP0000703_abnormal_thymus_morphology0.96257937
114MP0003303_peritoneal_inflammation0.94883017
115MP0001533_abnormal_skeleton_physiology0.94173100
116MP0001764_abnormal_homeostasis0.93960590
117MP0006035_abnormal_mitochondrial_morpho0.93471888
118MP0003635_abnormal_synaptic_transmissio0.93094464
119MP0001963_abnormal_hearing_physiology0.92730061
120MP0005623_abnormal_meninges_morphology0.91106356
121MP0005195_abnormal_posterior_eye0.88787392
122MP0002063_abnormal_learning/memory/cond0.85757322
123MP0002064_seizures0.85179523
124MP0002653_abnormal_ependyma_morphology0.85140326
125MP0002095_abnormal_skin_pigmentation0.84700453
126MP0000762_abnormal_tongue_morphology0.84470712
127MP0009046_muscle_twitch0.84125155
128MP0002882_abnormal_neuron_morphology0.82585331
129MP0005551_abnormal_eye_electrophysiolog0.82018481
130MP0008469_abnormal_protein_level0.81669685
131MP0002067_abnormal_sensory_capabilities0.81403013
132MP0002572_abnormal_emotion/affect_behav0.81000340
133MP0004272_abnormal_basement_membrane0.80671882
134MP0004510_myositis0.80583724
135MP0004215_abnormal_myocardial_fiber0.80577394
136MP0000015_abnormal_ear_pigmentation0.79643371
137MP0000639_abnormal_adrenal_gland0.79039912
138MP0002752_abnormal_somatic_nervous0.78681523
139MP0003191_abnormal_cellular_cholesterol0.77067143
140MP0000747_muscle_weakness0.76806006
141MP0002429_abnormal_blood_cell0.76261788
142MP0005388_respiratory_system_phenotype0.73557035
143MP0002133_abnormal_respiratory_system0.73557035
144MP0003633_abnormal_nervous_system0.73148131
145MP0002090_abnormal_vision0.72341165
146MP0009765_abnormal_xenobiotic_induced0.71101128
147MP0002066_abnormal_motor_capabilities/c0.68629960
148MP0001727_abnormal_embryo_implantation0.63216984
149MP0003718_maternal_effect0.62471151
150MP0001243_abnormal_dermal_layer0.62196278
151MP0002163_abnormal_gland_morphology0.61972202
152MP0004043_abnormal_pH_regulation0.60158087
153MP0004133_heterotaxia0.59384376
154MP0001348_abnormal_lacrimal_gland0.59186562
155MP0003453_abnormal_keratinocyte_physiol0.57823020
156MP0002148_abnormal_hypersensitivity_rea0.55480063
157MP0001340_abnormal_eyelid_morphology0.55130027
158MP0002419_abnormal_innate_immunity0.55119777
159MP0000377_abnormal_hair_follicle0.54496565
160MP0005584_abnormal_enzyme/coenzyme_acti0.53654188
161MP0000537_abnormal_urethra_morphology0.51761217
162MP0005253_abnormal_eye_physiology0.51417798
163MP0001293_anophthalmia0.50399651
164MP0000026_abnormal_inner_ear0.50267502
165MP0005000_abnormal_immune_tolerance0.49769165
166MP0003385_abnormal_body_wall0.49621968
167MP0005503_abnormal_tendon_morphology0.49573526
168MP0002098_abnormal_vibrissa_morphology0.47970109
169MP0009333_abnormal_splenocyte_physiolog0.47768016

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.47907789
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.47907789
3Neurofibrillary tangles (HP:0002185)5.44936401
4Parakeratosis (HP:0001036)5.03013191
5Cerebral hypomyelination (HP:0006808)4.91347908
6Abnormality of the corticospinal tract (HP:0002492)4.43131952
7Sensory axonal neuropathy (HP:0003390)4.41718321
8Peripheral hypomyelination (HP:0007182)4.24127696
9Stomatitis (HP:0010280)4.15037916
10Increased serum pyruvate (HP:0003542)4.07531497
11Abnormality of glycolysis (HP:0004366)4.07531497
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.99772981
13Amyotrophic lateral sclerosis (HP:0007354)3.51413109
14Decreased electroretinogram (ERG) amplitude (HP:0000654)3.42157797
15Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.41848869
16Abnormal auditory evoked potentials (HP:0006958)3.33550231
17Cerebral inclusion bodies (HP:0100314)3.30289279
18Atrophy/Degeneration involving motor neurons (HP:0007373)3.28116986
19Increased IgM level (HP:0003496)3.24494599
20Onion bulb formation (HP:0003383)3.19708898
21Congenital ichthyosiform erythroderma (HP:0007431)3.17922625
22Spastic paraparesis (HP:0002313)3.11875472
23Hepatosplenomegaly (HP:0001433)3.07584885
24Retinal dysplasia (HP:0007973)3.06692731
25Autoamputation (HP:0001218)3.05106150
26Termporal pattern (HP:0011008)3.02787058
27Insidious onset (HP:0003587)3.02787058
28Segmental peripheral demyelination/remyelination (HP:0003481)3.01754677
29Premature skin wrinkling (HP:0100678)3.01712276
30Leukodystrophy (HP:0002415)2.98388144
31Acute necrotizing encephalopathy (HP:0006965)2.91749410
32Hypoplastic pelvis (HP:0008839)2.91130924
33Stridor (HP:0010307)2.90919563
34Spastic gait (HP:0002064)2.90565357
35Aplastic anemia (HP:0001915)2.83816280
36Alacrima (HP:0000522)2.81561539
37Mutism (HP:0002300)2.78011732
38Degeneration of anterior horn cells (HP:0002398)2.77260592
39Abnormality of the anterior horn cell (HP:0006802)2.77260592
40Progressive macrocephaly (HP:0004481)2.76501129
41Abnormality of the phalanges of the 2nd finger (HP:0009541)2.76339061
42Intention tremor (HP:0002080)2.75794117
43Adrenal hypoplasia (HP:0000835)2.74467097
44Patchy hypopigmentation of hair (HP:0011365)2.73537386
45Absent septum pellucidum (HP:0001331)2.69328670
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68991584
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68991584
48Pheochromocytoma (HP:0002666)2.67494872
49Neuroendocrine neoplasm (HP:0100634)2.66385961
50T lymphocytopenia (HP:0005403)2.65861405
51Abnormal mitochondria in muscle tissue (HP:0008316)2.65642218
52Mitochondrial inheritance (HP:0001427)2.65556284
53Medial flaring of the eyebrow (HP:0010747)2.64171001
54CNS hypomyelination (HP:0003429)2.63114444
55Abnormality of T cell number (HP:0011839)2.61218175
56Prolonged neonatal jaundice (HP:0006579)2.60759708
57Anteriorly placed anus (HP:0001545)2.60099811
58Irregular epiphyses (HP:0010582)2.60097783
59Supranuclear gaze palsy (HP:0000605)2.55514732
60Hypoproteinemia (HP:0003075)2.51624598
61Clumsiness (HP:0002312)2.48765123
62Small epiphyses (HP:0010585)2.48694124
63Cerebral hemorrhage (HP:0001342)2.48098750
64White forelock (HP:0002211)2.48087616
65Epiphyseal dysplasia (HP:0002656)2.44719746
66Polyphagia (HP:0002591)2.42907732
67IgG deficiency (HP:0004315)2.40874755
68Gait imbalance (HP:0002141)2.39803046
69Congenital primary aphakia (HP:0007707)2.39639138
70Slow saccadic eye movements (HP:0000514)2.37213371
71Morphological abnormality of the inner ear (HP:0011390)2.37003617
72Postnatal microcephaly (HP:0005484)2.35729078
73Coronal craniosynostosis (HP:0004440)2.34602177
743-Methylglutaconic aciduria (HP:0003535)2.33818012
75Elevated erythrocyte sedimentation rate (HP:0003565)2.33449412
76Akinesia (HP:0002304)2.32208845
77Hepatocellular necrosis (HP:0001404)2.31519978
78Abnormality of the septum pellucidum (HP:0007375)2.30367195
79Increased CSF lactate (HP:0002490)2.30134213
80Increased hepatocellular lipid droplets (HP:0006565)2.29070404
81Volvulus (HP:0002580)2.28445637
82Renal Fanconi syndrome (HP:0001994)2.28178366
83Nephrogenic diabetes insipidus (HP:0009806)2.25593944
84Acute encephalopathy (HP:0006846)2.25172599
85Anomalous pulmonary venous return (HP:0010772)2.24216217
86Progressive inability to walk (HP:0002505)2.23135915
87Scanning speech (HP:0002168)2.22179956
88Brushfield spots (HP:0001088)2.21582278
89Decreased lacrimation (HP:0000633)2.21008128
90Abnormality of macular pigmentation (HP:0008002)2.20421541
91Erythroderma (HP:0001019)2.18582778
92Type II lissencephaly (HP:0007260)2.18193462
93Stenosis of the external auditory canal (HP:0000402)2.17545783
94Methylmalonic aciduria (HP:0012120)2.16366885
95Split foot (HP:0001839)2.15716019
96Esophageal atresia (HP:0002032)2.14827485
97Hepatic necrosis (HP:0002605)2.14754369
98Hemiplegia (HP:0002301)2.12740014
99Autoimmune hemolytic anemia (HP:0001890)2.11336107
100Increased intramyocellular lipid droplets (HP:0012240)2.11306589
101Abnormal umbilical cord blood vessels (HP:0011403)2.10570215
102Single umbilical artery (HP:0001195)2.10570215
103Abnormality of the fetal cardiovascular system (HP:0010948)2.10570215
104Methylmalonic acidemia (HP:0002912)2.10565806
105Delayed epiphyseal ossification (HP:0002663)2.10186976
106Thickened helices (HP:0000391)2.10005905
107Paraparesis (HP:0002385)2.09381880
108Abnormality of macrophages (HP:0004311)2.09061439
109Cupped ear (HP:0000378)2.08980976
110Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08741839
111Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08653176
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04183402
113Dysmetria (HP:0001310)2.04077309
114Relative macrocephaly (HP:0004482)2.03461399
115Constricted visual fields (HP:0001133)2.02271125
116Increased circulating renin level (HP:0000848)2.01006378
117Lactic acidosis (HP:0003128)2.00149333
118Lipid accumulation in hepatocytes (HP:0006561)2.00080392
119Abnormality of the pulmonary veins (HP:0011718)2.00034464
120Cerebral edema (HP:0002181)1.99936369
121Barrel-shaped chest (HP:0001552)1.99842755
122Abnormal glycosylation (HP:0012345)1.98548277
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98548277
124Abnormal protein N-linked glycosylation (HP:0012347)1.98548277
125Abnormal protein glycosylation (HP:0012346)1.98548277
126Stomach cancer (HP:0012126)1.98453416
127Eosinophilia (HP:0001880)1.98399363
128Abnormality of the vitreous humor (HP:0004327)1.97666037
129Metaphyseal dysplasia (HP:0100255)1.97371361
130Abnormality of the umbilical cord (HP:0010881)1.96774762
131Axonal loss (HP:0003447)1.93721021
132Respiratory failure (HP:0002878)1.93563643
133Agnosia (HP:0010524)1.93557992
134Short tibia (HP:0005736)1.92205445
135Abolished electroretinogram (ERG) (HP:0000550)1.89716806
136Severe combined immunodeficiency (HP:0004430)1.87623878
137Petechiae (HP:0000967)1.86849576
138Type I transferrin isoform profile (HP:0003642)1.86737362
139Episodic fever (HP:0001954)1.86592822
140Posterior subcapsular cataract (HP:0007787)1.86475191
141Infantile muscular hypotonia (HP:0008947)1.86033993
142Abnormality of the labia minora (HP:0012880)1.84669788
143Abnormality of eosinophils (HP:0001879)1.84035575
144Septo-optic dysplasia (HP:0100842)1.83179252
145Abnormal neuron morphology (HP:0012757)1.81719784
146Abnormality of the motor neurons (HP:0002450)1.81719784
147Disinhibition (HP:0000734)1.81384916
148Emotional lability (HP:0000712)1.81331795
149Papillary thyroid carcinoma (HP:0002895)1.81163625
150Exertional dyspnea (HP:0002875)1.81099476
151Gangrene (HP:0100758)1.79735335
152Sensorimotor neuropathy (HP:0007141)1.79458436
153Abnormality of incisor morphology (HP:0011063)1.78476845
154Prominent occiput (HP:0000269)1.78180817
155Partial duplication of thumb phalanx (HP:0009944)1.77860206
156Septate vagina (HP:0001153)1.77804180
157Gonadotropin excess (HP:0000837)1.77608296
158Hypoglycemic seizures (HP:0002173)1.77127458
159Hypophosphatemic rickets (HP:0004912)1.76897444
160Vacuolated lymphocytes (HP:0001922)1.75263682
161Joint swelling (HP:0001386)1.75252929
162Acute hepatic failure (HP:0006554)1.74764804
163Optic disc pallor (HP:0000543)1.73712165
164Cholecystitis (HP:0001082)1.73164971
165Abnormal gallbladder physiology (HP:0012438)1.73164971
166Abnormality of T cells (HP:0002843)1.72493025
167Diastasis recti (HP:0001540)1.71390876
168Poor speech (HP:0002465)1.71109587
169Hypomagnesemia (HP:0002917)1.68169563
170Shoulder girdle muscle weakness (HP:0003547)1.67765279
171Partial agenesis of the corpus callosum (HP:0001338)1.67671262
172Leukocytosis (HP:0001974)1.66997704
173Choreoathetosis (HP:0001266)1.66985011
174Steatorrhea (HP:0002570)1.66683848
175Clitoromegaly (HP:0000057)1.65962977
176Absent epiphyses (HP:0010577)1.64740345
177Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64740345
178Peripheral demyelination (HP:0011096)1.64210692
179Megalencephaly (HP:0001355)1.63805373
180Spastic tetraparesis (HP:0001285)1.61920525
181Progressive neurologic deterioration (HP:0002344)1.61523928
182Urinary incontinence (HP:0000020)1.61446575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.23447926
2EPHB14.31842447
3OXSR14.08402901
4PBK4.08252786
5BCR3.36882267
6MAP4K23.02470625
7BCKDK2.65291347
8TESK22.59583274
9LIMK12.55645245
10MET2.49253773
11MAPKAPK52.44045274
12WNK42.21999781
13PKN12.03916889
14MST42.03517093
15NEK61.99419120
16CSNK1G31.98779248
17CDK191.94598462
18FES1.94135632
19CSNK1A1L1.90008094
20FGFR21.87924421
21CLK11.83094108
22TNIK1.77999070
23UHMK11.77290578
24TSSK61.75287694
25PRPF4B1.72765246
26PINK11.68002824
27TRIM281.62974993
28DYRK21.60694147
29WNK11.58381930
30SIK31.51023429
31SRPK11.46324220
32MKNK11.43075922
33CSNK1G11.42241436
34TEC1.41920382
35PLK21.40475161
36KDR1.39730401
37MAP3K121.30384352
38CCNB11.29219501
39BUB11.28386594
40NTRK21.27904506
41MAP3K41.26662663
42ROCK21.25857565
43TAOK31.25045810
44BMPR1B1.21741856
45STK161.17961118
46CSNK1G21.17280283
47KIT1.16821604
48MAP2K71.15542824
49CAMK2B1.10813395
50IRAK11.08271026
51IRAK21.05942641
52CAMKK21.03347364
53MAP3K50.99461864
54ADRBK20.98699214
55TIE10.98657338
56SGK2230.94464720
57SGK4940.94464720
58MINK10.93901045
59RPS6KA50.93734414
60CAMK2D0.90963304
61CSK0.90239425
62GRK70.90166876
63EPHA40.89911677
64NTRK10.88224739
65RPS6KA40.87197836
66IKBKE0.85486420
67SYK0.85053246
68PRKCQ0.82119632
69CDK140.82008192
70EPHA30.81819657
71GRK10.81529664
72INSRR0.79007276
73EIF2AK30.78228020
74FGR0.78018455
75LYN0.76438521
76PLK30.75280504
77ARAF0.74217499
78ICK0.70713720
79EIF2AK10.69930748
80MAP3K110.69528790
81DAPK10.68748258
82GRK60.68125319
83NEK10.65597955
84ERBB40.64176244
85CAMK2G0.63982338
86IRAK40.61837947
87CDK150.59657723
88MAPK130.59160982
89CDK180.59137172
90PIM20.58066143
91PNCK0.58040804
92KSR10.57538480
93GSK3A0.56913693
94RIPK40.56385117
95PAK30.56385037
96BMPR20.55745528
97MOS0.55504114
98PRKD10.53699785
99EGFR0.53062177
100PAK60.52019732
101TYRO30.51578208
102DYRK30.50927097
103CDK11A0.50527063
104RAF10.50133487
105FER0.49813762
106GRK50.48596723
107DAPK20.48357559
108PIM10.47999706
109PAK10.47842503
110MARK30.46951777
111ABL20.46902484
112PRKCG0.46195310
113CDK30.46060533
114JAK20.45680986
115TRPM70.45291810
116JAK30.44396143
117TAOK20.43241227
118STK38L0.42963311
119PRKCE0.42670778
120MATK0.42128163
121STK100.41330745
122ACVR1B0.37849341
123CSNK1D0.36542743
124YES10.36088590
125ITK0.35797410
126MAPK150.35483482
127CSNK1A10.34834930
128VRK10.32632328
129MUSK0.31943178
130CAMK2A0.31441932
131TESK10.29839277
132WNK30.29604658
133PRKD30.29559416
134FYN0.28922328
135STK40.28732372
136CDK50.28547281
137ERBB30.26355388
138IKBKB0.25888622
139BRAF0.25266227
140PIK3CA0.25214498
141LCK0.24504237
142NUAK10.24486160
143ABL10.24209396
144TBK10.22743021
145PRKACB0.21565639
146MELK0.21205559
147INSR0.21062129
148PDGFRB0.20699651
149MAP2K20.20571457
150MAPKAPK20.20055483
151PRKG10.20021677
152TXK0.18789439
153CSF1R0.18504398
154HIPK20.18118101
155DDR20.16984102

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.76150551
2Steroid biosynthesis_Homo sapiens_hsa001005.83284904
3Fatty acid elongation_Homo sapiens_hsa000624.65919327
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.13311409
5Protein export_Homo sapiens_hsa030603.10354270
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.05483933
7Ether lipid metabolism_Homo sapiens_hsa005653.03620168
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.88738924
9Sulfur metabolism_Homo sapiens_hsa009202.11922563
10Vitamin B6 metabolism_Homo sapiens_hsa007502.01648827
11Antigen processing and presentation_Homo sapiens_hsa046121.98334890
12Proteasome_Homo sapiens_hsa030501.89335501
13Primary immunodeficiency_Homo sapiens_hsa053401.87609412
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85182945
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73415257
16Type I diabetes mellitus_Homo sapiens_hsa049401.72165694
17Legionellosis_Homo sapiens_hsa051341.69119134
18Sphingolipid metabolism_Homo sapiens_hsa006001.64746554
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63369297
20Linoleic acid metabolism_Homo sapiens_hsa005911.52622484
21Histidine metabolism_Homo sapiens_hsa003401.51008766
22Synaptic vesicle cycle_Homo sapiens_hsa047211.49107775
23Butanoate metabolism_Homo sapiens_hsa006501.38600413
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38427409
25Hematopoietic cell lineage_Homo sapiens_hsa046401.34410910
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33911776
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33118708
28Oxidative phosphorylation_Homo sapiens_hsa001901.25441241
29Glutathione metabolism_Homo sapiens_hsa004801.23641269
30Arginine and proline metabolism_Homo sapiens_hsa003301.20256344
31Folate biosynthesis_Homo sapiens_hsa007901.19950553
32beta-Alanine metabolism_Homo sapiens_hsa004101.14750437
33Axon guidance_Homo sapiens_hsa043601.14252159
34Basal transcription factors_Homo sapiens_hsa030221.03724853
35RNA degradation_Homo sapiens_hsa030181.02726566
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02301824
37Viral myocarditis_Homo sapiens_hsa054161.01914200
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00898270
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98219690
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98185798
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98184520
42Phototransduction_Homo sapiens_hsa047440.98159213
43Lysosome_Homo sapiens_hsa041420.98016576
44Peroxisome_Homo sapiens_hsa041460.97869958
45RNA polymerase_Homo sapiens_hsa030200.95967247
46Measles_Homo sapiens_hsa051620.95926380
47Arachidonic acid metabolism_Homo sapiens_hsa005900.95657871
48Circadian rhythm_Homo sapiens_hsa047100.94145650
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93417109
50Renal cell carcinoma_Homo sapiens_hsa052110.91467406
51GABAergic synapse_Homo sapiens_hsa047270.89559966
52Parkinsons disease_Homo sapiens_hsa050120.87944555
53Phagosome_Homo sapiens_hsa041450.86873315
54Nicotine addiction_Homo sapiens_hsa050330.84690563
55Autoimmune thyroid disease_Homo sapiens_hsa053200.82613853
56T cell receptor signaling pathway_Homo sapiens_hsa046600.81439654
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81280591
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81006224
59Rheumatoid arthritis_Homo sapiens_hsa053230.80903560
60Allograft rejection_Homo sapiens_hsa053300.80619390
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79659958
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78392163
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78289711
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.78218288
65Malaria_Homo sapiens_hsa051440.76892832
66Vibrio cholerae infection_Homo sapiens_hsa051100.74251516
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.71658544
68Tuberculosis_Homo sapiens_hsa051520.70433785
69Propanoate metabolism_Homo sapiens_hsa006400.69683739
70Fatty acid metabolism_Homo sapiens_hsa012120.69281292
71Regulation of autophagy_Homo sapiens_hsa041400.68061056
72Graft-versus-host disease_Homo sapiens_hsa053320.67752700
73Leishmaniasis_Homo sapiens_hsa051400.67117580
74Non-homologous end-joining_Homo sapiens_hsa034500.65829132
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65452628
76Tight junction_Homo sapiens_hsa045300.63857904
77Oocyte meiosis_Homo sapiens_hsa041140.62838325
78Alzheimers disease_Homo sapiens_hsa050100.60019236
79Endocytosis_Homo sapiens_hsa041440.59583419
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55689313
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54171417
82Metabolic pathways_Homo sapiens_hsa011000.54104975
83Herpes simplex infection_Homo sapiens_hsa051680.52397814
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51516316
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50642525
86Chemokine signaling pathway_Homo sapiens_hsa040620.49742347
87Retinol metabolism_Homo sapiens_hsa008300.49214526
88Shigellosis_Homo sapiens_hsa051310.49036958
89Epstein-Barr virus infection_Homo sapiens_hsa051690.48654845
90Chemical carcinogenesis_Homo sapiens_hsa052040.48374861
91Nitrogen metabolism_Homo sapiens_hsa009100.48088167
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46769550
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46677019
94Morphine addiction_Homo sapiens_hsa050320.46529989
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45411815
96Purine metabolism_Homo sapiens_hsa002300.42936654
97Base excision repair_Homo sapiens_hsa034100.42651475
98Osteoclast differentiation_Homo sapiens_hsa043800.42091580
99Staphylococcus aureus infection_Homo sapiens_hsa051500.41265533
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40834515
101Nucleotide excision repair_Homo sapiens_hsa034200.39091821
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38564360
103Mismatch repair_Homo sapiens_hsa034300.36728485
104Homologous recombination_Homo sapiens_hsa034400.35915197
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35802815
106African trypanosomiasis_Homo sapiens_hsa051430.35599548
107Carbon metabolism_Homo sapiens_hsa012000.34757787
108Fanconi anemia pathway_Homo sapiens_hsa034600.34727509
109Pyrimidine metabolism_Homo sapiens_hsa002400.34257270
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.33558949
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32660322
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.31571376
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29853182
114Ovarian steroidogenesis_Homo sapiens_hsa049130.29423318
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.29201349
116Collecting duct acid secretion_Homo sapiens_hsa049660.29001168
117Ras signaling pathway_Homo sapiens_hsa040140.28743959
118Asthma_Homo sapiens_hsa053100.27763436
119Spliceosome_Homo sapiens_hsa030400.27707377
120Huntingtons disease_Homo sapiens_hsa050160.26469974
121Salmonella infection_Homo sapiens_hsa051320.26380171
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25729711
123Serotonergic synapse_Homo sapiens_hsa047260.24789121
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22501991
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.22074873
126ECM-receptor interaction_Homo sapiens_hsa045120.21943757
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.21567155
128Prion diseases_Homo sapiens_hsa050200.20651595
129Long-term depression_Homo sapiens_hsa047300.20577458
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19986833
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19337358
132Pertussis_Homo sapiens_hsa051330.18194968
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17894746
134Vitamin digestion and absorption_Homo sapiens_hsa049770.17193610
135Pyruvate metabolism_Homo sapiens_hsa006200.14819048
136Prostate cancer_Homo sapiens_hsa052150.14566450
137Tyrosine metabolism_Homo sapiens_hsa003500.13090543
138Hedgehog signaling pathway_Homo sapiens_hsa043400.12105611
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10674967
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10344559
141Mineral absorption_Homo sapiens_hsa049780.08838181
142DNA replication_Homo sapiens_hsa030300.08762451
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.07846321

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