

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 6.82113424 |
| 2 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.86493391 |
| 3 | presynaptic membrane assembly (GO:0097105) | 5.85585956 |
| 4 | vocalization behavior (GO:0071625) | 5.84400823 |
| 5 | glutamate secretion (GO:0014047) | 5.70381770 |
| 6 | synaptic vesicle exocytosis (GO:0016079) | 5.69333933 |
| 7 | neurotransmitter-gated ion channel clustering (GO:0072578) | 5.64758305 |
| 8 | neuron cell-cell adhesion (GO:0007158) | 5.57265276 |
| 9 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.50418996 |
| 10 | cellular potassium ion homeostasis (GO:0030007) | 5.48764238 |
| 11 | presynaptic membrane organization (GO:0097090) | 5.38065945 |
| 12 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.32289820 |
| 13 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 5.28714012 |
| 14 | protein localization to synapse (GO:0035418) | 5.26158670 |
| 15 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.23149845 |
| 16 | postsynaptic membrane organization (GO:0001941) | 5.19915138 |
| 17 | sodium ion export (GO:0071436) | 5.00735109 |
| 18 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.97951234 |
| 19 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 4.93229453 |
| 20 | regulation of synaptic vesicle transport (GO:1902803) | 4.70756551 |
| 21 | neuronal action potential propagation (GO:0019227) | 4.70224182 |
| 22 | cerebellar granule cell differentiation (GO:0021707) | 4.49028708 |
| 23 | synaptic vesicle maturation (GO:0016188) | 4.44870711 |
| 24 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.33501722 |
| 25 | negative regulation of dendrite morphogenesis (GO:0050774) | 4.28858059 |
| 26 | neurotransmitter secretion (GO:0007269) | 4.24938636 |
| 27 | positive regulation of neurotransmitter secretion (GO:0001956) | 4.21874556 |
| 28 | synaptic transmission, glutamatergic (GO:0035249) | 4.21807162 |
| 29 | L-amino acid import (GO:0043092) | 4.21662000 |
| 30 | neuron-neuron synaptic transmission (GO:0007270) | 4.18632114 |
| 31 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.13239695 |
| 32 | positive regulation of synapse maturation (GO:0090129) | 4.10321659 |
| 33 | regulation of ARF protein signal transduction (GO:0032012) | 4.02214803 |
| 34 | dendritic spine morphogenesis (GO:0060997) | 4.00621146 |
| 35 | locomotory exploration behavior (GO:0035641) | 3.99735703 |
| 36 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.96648704 |
| 37 | mechanosensory behavior (GO:0007638) | 3.92730877 |
| 38 | glutamate receptor signaling pathway (GO:0007215) | 3.91682721 |
| 39 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.88582240 |
| 40 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.88371812 |
| 41 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.87143534 |
| 42 | potassium ion import (GO:0010107) | 3.84434402 |
| 43 | regulation of neurotransmitter secretion (GO:0046928) | 3.77138211 |
| 44 | long-term synaptic potentiation (GO:0060291) | 3.75002331 |
| 45 | regulation of postsynaptic membrane potential (GO:0060078) | 3.74082821 |
| 46 | positive regulation of neurotransmitter transport (GO:0051590) | 3.72721979 |
| 47 | potassium ion homeostasis (GO:0055075) | 3.71769612 |
| 48 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.69629854 |
| 49 | positive regulation of dendritic spine development (GO:0060999) | 3.69403819 |
| 50 | amino acid import (GO:0043090) | 3.68289385 |
| 51 | neuronal ion channel clustering (GO:0045161) | 3.68105531 |
| 52 | response to histamine (GO:0034776) | 3.67751253 |
| 53 | positive regulation of membrane potential (GO:0045838) | 3.63700143 |
| 54 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.61572586 |
| 55 | transferrin transport (GO:0033572) | 3.59642495 |
| 56 | positive regulation of synapse assembly (GO:0051965) | 3.58345712 |
| 57 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.54264266 |
| 58 | auditory behavior (GO:0031223) | 3.53570207 |
| 59 | neuromuscular process controlling balance (GO:0050885) | 3.53365787 |
| 60 | regulation of glutamate secretion (GO:0014048) | 3.51798676 |
| 61 | negative regulation of dendrite development (GO:2000171) | 3.50716450 |
| 62 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.50108508 |
| 63 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.48324329 |
| 64 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.48324329 |
| 65 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.47035791 |
| 66 | regulation of synapse maturation (GO:0090128) | 3.46770095 |
| 67 | neuron recognition (GO:0008038) | 3.45526743 |
| 68 | long-term memory (GO:0007616) | 3.43979834 |
| 69 | exploration behavior (GO:0035640) | 3.43608957 |
| 70 | central nervous system myelination (GO:0022010) | 3.42007165 |
| 71 | axon ensheathment in central nervous system (GO:0032291) | 3.42007165 |
| 72 | layer formation in cerebral cortex (GO:0021819) | 3.38032537 |
| 73 | neurotransmitter transport (GO:0006836) | 3.36433998 |
| 74 | trivalent inorganic cation transport (GO:0072512) | 3.35635751 |
| 75 | ferric iron transport (GO:0015682) | 3.35635751 |
| 76 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.35275812 |
| 77 | startle response (GO:0001964) | 3.34115344 |
| 78 | regulation of neurotransmitter transport (GO:0051588) | 3.33945157 |
| 79 | regulation of synaptic plasticity (GO:0048167) | 3.33084538 |
| 80 | neuromuscular process controlling posture (GO:0050884) | 3.32962553 |
| 81 | cell communication by electrical coupling (GO:0010644) | 3.31583482 |
| 82 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.31446584 |
| 83 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.29218685 |
| 84 | chemosensory behavior (GO:0007635) | 3.25703375 |
| 85 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.23506652 |
| 86 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.22904376 |
| 87 | membrane depolarization (GO:0051899) | 3.21473336 |
| 88 | synapse assembly (GO:0007416) | 3.20189747 |
| 89 | cellular sodium ion homeostasis (GO:0006883) | 3.19496101 |
| 90 | positive regulation of synaptic transmission (GO:0050806) | 3.15439629 |
| 91 | axonal fasciculation (GO:0007413) | 3.14460777 |
| 92 | calcium ion-dependent exocytosis (GO:0017156) | 3.13602822 |
| 93 | gamma-aminobutyric acid transport (GO:0015812) | 3.13142206 |
| 94 | synaptic vesicle endocytosis (GO:0048488) | 3.12943351 |
| 95 | proline transport (GO:0015824) | 3.12275079 |
| 96 | dendritic spine organization (GO:0097061) | 3.11274394 |
| 97 | membrane depolarization during action potential (GO:0086010) | 3.11241953 |
| 98 | regulation of neurotransmitter levels (GO:0001505) | 3.10982202 |
| 99 | regulation of dendritic spine development (GO:0060998) | 3.08643372 |
| 100 | behavioral response to cocaine (GO:0048148) | 3.06735595 |
| 101 | regulation of synapse assembly (GO:0051963) | 3.05016781 |
| 102 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.04772725 |
| 103 | transmission of nerve impulse (GO:0019226) | 3.04212159 |
| 104 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.02333401 |
| 105 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.01953822 |
| 106 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.01189635 |
| 107 | response to auditory stimulus (GO:0010996) | 2.99864426 |
| 108 | innervation (GO:0060384) | 2.99066539 |
| 109 | synaptic transmission (GO:0007268) | 2.98258355 |
| 110 | regulation of synapse structural plasticity (GO:0051823) | 2.98223683 |
| 111 | regulation of vesicle fusion (GO:0031338) | 2.96876024 |
| 112 | regulation of female receptivity (GO:0045924) | 2.94778107 |
| 113 | regulation of synaptic transmission (GO:0050804) | 2.94056912 |
| 114 | detection of calcium ion (GO:0005513) | 2.93837978 |
| 115 | membrane hyperpolarization (GO:0060081) | 2.91718629 |
| 116 | serotonin metabolic process (GO:0042428) | 2.91525385 |
| 117 | synaptic vesicle transport (GO:0048489) | 2.91406440 |
| 118 | establishment of synaptic vesicle localization (GO:0097480) | 2.91406440 |
| 119 | female mating behavior (GO:0060180) | 2.91363572 |
| 120 | neuromuscular synaptic transmission (GO:0007274) | 2.91120574 |
| 121 | signal release (GO:0023061) | 2.90598308 |
| 122 | regulation of exocytosis (GO:0017157) | 2.90054891 |
| 123 | cell migration in hindbrain (GO:0021535) | 2.89957910 |
| 124 | activation of protein kinase A activity (GO:0034199) | 2.88120968 |
| 125 | cell differentiation in hindbrain (GO:0021533) | 2.88012558 |
| 126 | neurotransmitter uptake (GO:0001504) | 2.85999787 |
| 127 | establishment of mitochondrion localization (GO:0051654) | 2.85404422 |
| 128 | inositol phosphate catabolic process (GO:0071545) | 2.84741013 |
| 129 | membrane assembly (GO:0071709) | 2.84598307 |
| 130 | learning (GO:0007612) | 2.83856458 |
| 131 | acidic amino acid transport (GO:0015800) | 2.83591487 |
| 132 | regulation of respiratory system process (GO:0044065) | 2.81322712 |
| 133 | cell communication involved in cardiac conduction (GO:0086065) | 2.80831278 |
| 134 | dendrite development (GO:0016358) | 2.79383655 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.19611800 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.66863146 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.06552289 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.89703674 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.83658234 |
| 6 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.64284665 |
| 7 | * EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.52886369 |
| 8 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.51545688 |
| 9 | * TAF15_26573619_Chip-Seq_HEK293_Human | 2.48779949 |
| 10 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.46715738 |
| 11 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.45081169 |
| 12 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.42542063 |
| 13 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.42542063 |
| 14 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.41307217 |
| 15 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.40273423 |
| 16 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.39421339 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.39127239 |
| 18 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.32338521 |
| 19 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.32139266 |
| 20 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.30353083 |
| 21 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.24586522 |
| 22 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.18907564 |
| 23 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.16567832 |
| 24 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.15185597 |
| 25 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.09844183 |
| 26 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.09407426 |
| 27 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.02813326 |
| 28 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.98064198 |
| 29 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.95666148 |
| 30 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.94771483 |
| 31 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.93937072 |
| 32 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.89016497 |
| 33 | P300_19829295_ChIP-Seq_ESCs_Human | 1.89001864 |
| 34 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.88298073 |
| 35 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.82653252 |
| 36 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.78987073 |
| 37 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.76368544 |
| 38 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.73916432 |
| 39 | KDM2B_26808549_Chip-Seq_K562_Human | 1.73765150 |
| 40 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.73610908 |
| 41 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.72056563 |
| 42 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.67133075 |
| 43 | VDR_22108803_ChIP-Seq_LS180_Human | 1.65069791 |
| 44 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.64006850 |
| 45 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.60676503 |
| 46 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.59051926 |
| 47 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.58806099 |
| 48 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.53935698 |
| 49 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.52716514 |
| 50 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.51223103 |
| 51 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.49139260 |
| 52 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.49117937 |
| 53 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.48828351 |
| 54 | AR_25329375_ChIP-Seq_VCAP_Human | 1.48573554 |
| 55 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.47209065 |
| 56 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.42856480 |
| 57 | FUS_26573619_Chip-Seq_HEK293_Human | 1.42065931 |
| 58 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.41602948 |
| 59 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.41273951 |
| 60 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.40403197 |
| 61 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.40073994 |
| 62 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.38428722 |
| 63 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.37523670 |
| 64 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.33682871 |
| 65 | STAT3_23295773_ChIP-Seq_U87_Human | 1.33054974 |
| 66 | * TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.31343974 |
| 67 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.30410985 |
| 68 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.29584066 |
| 69 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.28516967 |
| 70 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.28494000 |
| 71 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.27301366 |
| 72 | TCF4_23295773_ChIP-Seq_U87_Human | 1.26136755 |
| 73 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.25357556 |
| 74 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.25101995 |
| 75 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.22143933 |
| 76 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.21579300 |
| 77 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.21562576 |
| 78 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.21133118 |
| 79 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.20433637 |
| 80 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.18456461 |
| 81 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.17182869 |
| 82 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.17102123 |
| 83 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.16869470 |
| 84 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.16670526 |
| 85 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.15581681 |
| 86 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.15213745 |
| 87 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.15128996 |
| 88 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.13912342 |
| 89 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.11701617 |
| 90 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.11573336 |
| 91 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.10577515 |
| 92 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.09528139 |
| 93 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.09275995 |
| 94 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.08850608 |
| 95 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.08096122 |
| 96 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08018982 |
| 97 | AR_19668381_ChIP-Seq_PC3_Human | 1.07784511 |
| 98 | JUN_21703547_ChIP-Seq_K562_Human | 1.07136914 |
| 99 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.05825229 |
| 100 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.04821260 |
| 101 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.04331368 |
| 102 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.03297413 |
| 103 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03297413 |
| 104 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.02416772 |
| 105 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.02339484 |
| 106 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.02114268 |
| 107 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.02000363 |
| 108 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.01953625 |
| 109 | * KDM2B_26808549_Chip-Seq_REH_Human | 1.01814186 |
| 110 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.01666336 |
| 111 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.01376153 |
| 112 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.01267000 |
| 113 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.01006298 |
| 114 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.00236716 |
| 115 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.00199412 |
| 116 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.99995155 |
| 117 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.99585250 |
| 118 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.99480814 |
| 119 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.99183517 |
| 120 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.98909502 |
| 121 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.98696493 |
| 122 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.97589518 |
| 123 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.96680028 |
| 124 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.95562579 |
| 125 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.95417404 |
| 126 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.94471545 |
| 127 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.93665788 |
| 128 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.92095476 |
| 129 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.91982490 |
| 130 | * KLF4_19829295_ChIP-Seq_ESCs_Human | 0.83930855 |
| 131 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.83831339 |
| 132 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.82369001 |
| 133 | * SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.81819591 |
| 134 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.79848579 |
| 135 | * KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.77402989 |
| 136 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.77282084 |
| 137 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.76744190 |
| 138 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.76018349 |
| 139 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.72542826 |
| 140 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.71763772 |
| 141 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.69368553 |
| 142 | P68_20966046_ChIP-Seq_HELA_Human | 0.69126929 |
| 143 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.67433455 |
| 144 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.66192482 |
| 145 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.65113762 |
| 146 | * SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.65093650 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 5.46278765 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 4.94579172 |
| 3 | MP0001968_abnormal_touch/_nociception | 3.86892732 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.77651831 |
| 5 | MP0004270_analgesia | 3.75702272 |
| 6 | MP0002736_abnormal_nociception_after | 3.43851442 |
| 7 | MP0009745_abnormal_behavioral_response | 3.25875388 |
| 8 | MP0009046_muscle_twitch | 3.23774986 |
| 9 | MP0002735_abnormal_chemical_nociception | 3.22646560 |
| 10 | MP0002063_abnormal_learning/memory/cond | 3.12559620 |
| 11 | MP0002064_seizures | 3.11018453 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.93603997 |
| 13 | MP0002572_abnormal_emotion/affect_behav | 2.81105942 |
| 14 | MP0002272_abnormal_nervous_system | 2.63676371 |
| 15 | MP0009780_abnormal_chondrocyte_physiolo | 2.38870706 |
| 16 | MP0002067_abnormal_sensory_capabilities | 2.32940280 |
| 17 | MP0003879_abnormal_hair_cell | 2.31960257 |
| 18 | MP0001486_abnormal_startle_reflex | 2.20176514 |
| 19 | MP0006276_abnormal_autonomic_nervous | 2.18443700 |
| 20 | MP0001440_abnormal_grooming_behavior | 2.15431718 |
| 21 | MP0002733_abnormal_thermal_nociception | 2.13054566 |
| 22 | MP0001501_abnormal_sleep_pattern | 2.11395951 |
| 23 | MP0003787_abnormal_imprinting | 2.09620915 |
| 24 | MP0005423_abnormal_somatic_nervous | 2.06197378 |
| 25 | MP0001970_abnormal_pain_threshold | 2.04412910 |
| 26 | MP0002876_abnormal_thyroid_physiology | 2.00236448 |
| 27 | MP0003690_abnormal_glial_cell | 1.95850662 |
| 28 | MP0001984_abnormal_olfaction | 1.94682405 |
| 29 | MP0002184_abnormal_innervation | 1.93249971 |
| 30 | MP0001188_hyperpigmentation | 1.91538997 |
| 31 | MP0005645_abnormal_hypothalamus_physiol | 1.90194228 |
| 32 | MP0005646_abnormal_pituitary_gland | 1.86392808 |
| 33 | MP0000778_abnormal_nervous_system | 1.75926723 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.75696026 |
| 35 | MP0008569_lethality_at_weaning | 1.73539391 |
| 36 | MP0000920_abnormal_myelination | 1.71941717 |
| 37 | MP0004924_abnormal_behavior | 1.68053301 |
| 38 | MP0005386_behavior/neurological_phenoty | 1.68053301 |
| 39 | MP0004811_abnormal_neuron_physiology | 1.56540000 |
| 40 | MP0002822_catalepsy | 1.56121732 |
| 41 | MP0003183_abnormal_peptide_metabolism | 1.50454454 |
| 42 | MP0004142_abnormal_muscle_tone | 1.47741477 |
| 43 | MP0003122_maternal_imprinting | 1.47439680 |
| 44 | MP0001529_abnormal_vocalization | 1.45551768 |
| 45 | MP0004858_abnormal_nervous_system | 1.37948906 |
| 46 | MP0000955_abnormal_spinal_cord | 1.33903097 |
| 47 | MP0002066_abnormal_motor_capabilities/c | 1.33084935 |
| 48 | MP0001905_abnormal_dopamine_level | 1.32686121 |
| 49 | MP0002882_abnormal_neuron_morphology | 1.32141588 |
| 50 | MP0001502_abnormal_circadian_rhythm | 1.31247988 |
| 51 | MP0002837_dystrophic_cardiac_calcinosis | 1.28865973 |
| 52 | MP0003123_paternal_imprinting | 1.23663758 |
| 53 | MP0000604_amyloidosis | 1.21653388 |
| 54 | MP0002638_abnormal_pupillary_reflex | 1.20933616 |
| 55 | MP0002909_abnormal_adrenal_gland | 1.18124496 |
| 56 | MP0003633_abnormal_nervous_system | 1.17833037 |
| 57 | MP0003329_amyloid_beta_deposits | 1.12845821 |
| 58 | MP0005171_absent_coat_pigmentation | 1.11917422 |
| 59 | MP0004742_abnormal_vestibular_system | 1.09896859 |
| 60 | MP0003172_abnormal_lysosome_physiology | 1.09479283 |
| 61 | MP0001963_abnormal_hearing_physiology | 1.03254571 |
| 62 | MP0000751_myopathy | 1.02755921 |
| 63 | MP0010386_abnormal_urinary_bladder | 1.01903341 |
| 64 | MP0005167_abnormal_blood-brain_barrier | 1.00342155 |
| 65 | MP0003075_altered_response_to | 0.98640836 |
| 66 | MP0003631_nervous_system_phenotype | 0.98159200 |
| 67 | MP0008004_abnormal_stomach_pH | 0.97737149 |
| 68 | MP0001986_abnormal_taste_sensitivity | 0.95275204 |
| 69 | MP0002152_abnormal_brain_morphology | 0.94456694 |
| 70 | MP0008872_abnormal_physiological_respon | 0.93149438 |
| 71 | MP0005394_taste/olfaction_phenotype | 0.91531299 |
| 72 | MP0005499_abnormal_olfactory_system | 0.91531299 |
| 73 | MP0002069_abnormal_eating/drinking_beha | 0.89953298 |
| 74 | MP0002229_neurodegeneration | 0.89405794 |
| 75 | MP0008874_decreased_physiological_sensi | 0.88141225 |
| 76 | MP0004145_abnormal_muscle_electrophysio | 0.87920995 |
| 77 | MP0000579_abnormal_nail_morphology | 0.87195287 |
| 78 | MP0002751_abnormal_autonomic_nervous | 0.85441331 |
| 79 | MP0000631_abnormal_neuroendocrine_gland | 0.84799289 |
| 80 | MP0004085_abnormal_heartbeat | 0.84494849 |
| 81 | MP0004510_myositis | 0.83905781 |
| 82 | MP0001664_abnormal_digestion | 0.82201250 |
| 83 | MP0001485_abnormal_pinna_reflex | 0.81923639 |
| 84 | MP0005409_darkened_coat_color | 0.81117760 |
| 85 | MP0002752_abnormal_somatic_nervous | 0.79348012 |
| 86 | MP0004885_abnormal_endolymph | 0.77800896 |
| 87 | MP0000013_abnormal_adipose_tissue | 0.77796394 |
| 88 | MP0005551_abnormal_eye_electrophysiolog | 0.76585932 |
| 89 | MP0002653_abnormal_ependyma_morphology | 0.74958108 |
| 90 | MP0001348_abnormal_lacrimal_gland | 0.74271933 |
| 91 | MP0005535_abnormal_body_temperature | 0.73794380 |
| 92 | MP0004130_abnormal_muscle_cell | 0.71276142 |
| 93 | MP0008877_abnormal_DNA_methylation | 0.71065240 |
| 94 | MP0004043_abnormal_pH_regulation | 0.71012491 |
| 95 | MP0004484_altered_response_of | 0.70183505 |
| 96 | MP0000026_abnormal_inner_ear | 0.69233671 |
| 97 | MP0002160_abnormal_reproductive_system | 0.68430320 |
| 98 | MP0003283_abnormal_digestive_organ | 0.65125365 |
| 99 | MP0004215_abnormal_myocardial_fiber | 0.62946263 |
| 100 | MP0003121_genomic_imprinting | 0.62878411 |
| 101 | MP0001943_abnormal_respiration | 0.59782885 |
| 102 | MP0003634_abnormal_glial_cell | 0.55882321 |
| 103 | MP0008789_abnormal_olfactory_epithelium | 0.54560830 |
| 104 | MP0001177_atelectasis | 0.53556840 |
| 105 | MP0000569_abnormal_digit_pigmentation | 0.53038525 |
| 106 | MP0002082_postnatal_lethality | 0.51355115 |
| 107 | MP0010770_preweaning_lethality | 0.51355115 |
| 108 | MP0004147_increased_porphyrin_level | 0.51230484 |
| 109 | MP0003632_abnormal_nervous_system | 0.50919060 |
| 110 | MP0005166_decreased_susceptibility_to | 0.49483475 |
| 111 | MP0010769_abnormal_survival | 0.49465034 |
| 112 | MP0003646_muscle_fatigue | 0.49000526 |
| 113 | MP0008260_abnormal_autophagy | 0.48466195 |
| 114 | MP0001765_abnormal_ion_homeostasis | 0.48186965 |
| 115 | MP0003956_abnormal_body_size | 0.47734199 |
| 116 | MP0000681_abnormal_thyroid_gland | 0.47409298 |
| 117 | MP0010768_mortality/aging | 0.46792061 |
| 118 | MP0004381_abnormal_hair_follicle | 0.46510858 |
| 119 | MP0002090_abnormal_vision | 0.43896504 |
| 120 | MP0000015_abnormal_ear_pigmentation | 0.43555890 |
| 121 | MP0005448_abnormal_energy_balance | 0.42444489 |
| 122 | MP0002089_abnormal_postnatal_growth/wei | 0.41673225 |
| 123 | MP0003045_fibrosis | 0.39409302 |
| 124 | MP0002078_abnormal_glucose_homeostasis | 0.39289989 |
| 125 | MP0002873_normal_phenotype | 0.39033418 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 8.61783412 |
| 2 | Atonic seizures (HP:0010819) | 6.47624587 |
| 3 | Epileptic encephalopathy (HP:0200134) | 6.40434173 |
| 4 | Hyperventilation (HP:0002883) | 5.82822045 |
| 5 | Febrile seizures (HP:0002373) | 5.67124507 |
| 6 | Focal seizures (HP:0007359) | 5.54316554 |
| 7 | Myokymia (HP:0002411) | 5.09551536 |
| 8 | Absence seizures (HP:0002121) | 4.58159332 |
| 9 | Neurofibrillary tangles (HP:0002185) | 4.43793763 |
| 10 | Dialeptic seizures (HP:0011146) | 4.33923513 |
| 11 | Mutism (HP:0002300) | 4.06143621 |
| 12 | Visual hallucinations (HP:0002367) | 4.05864229 |
| 13 | Progressive cerebellar ataxia (HP:0002073) | 4.03265969 |
| 14 | Broad-based gait (HP:0002136) | 4.00367190 |
| 15 | Generalized tonic-clonic seizures (HP:0002069) | 3.86182315 |
| 16 | Papilledema (HP:0001085) | 3.81335251 |
| 17 | Gaze-evoked nystagmus (HP:0000640) | 3.59696342 |
| 18 | Abnormal hair whorl (HP:0010721) | 3.50393024 |
| 19 | Cerebral inclusion bodies (HP:0100314) | 3.49869743 |
| 20 | Tetraplegia (HP:0002445) | 3.37055837 |
| 21 | Obstructive sleep apnea (HP:0002870) | 3.36851920 |
| 22 | Amblyopia (HP:0000646) | 3.21314721 |
| 23 | Hemiplegia (HP:0002301) | 3.18369928 |
| 24 | Annular pancreas (HP:0001734) | 3.08326030 |
| 25 | Neuronal loss in central nervous system (HP:0002529) | 2.99754877 |
| 26 | Dysmetric saccades (HP:0000641) | 2.98635755 |
| 27 | Gait imbalance (HP:0002141) | 2.98206725 |
| 28 | Abnormal eating behavior (HP:0100738) | 2.96106465 |
| 29 | Protruding tongue (HP:0010808) | 2.95198022 |
| 30 | Epileptiform EEG discharges (HP:0011182) | 2.92931981 |
| 31 | Pheochromocytoma (HP:0002666) | 2.90544556 |
| 32 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.89846439 |
| 33 | Focal dystonia (HP:0004373) | 2.86728237 |
| 34 | Peripheral hypomyelination (HP:0007182) | 2.85524417 |
| 35 | Intention tremor (HP:0002080) | 2.85114815 |
| 36 | Poor eye contact (HP:0000817) | 2.84459461 |
| 37 | Apathy (HP:0000741) | 2.84211321 |
| 38 | Truncal ataxia (HP:0002078) | 2.81160228 |
| 39 | Drooling (HP:0002307) | 2.78460495 |
| 40 | Excessive salivation (HP:0003781) | 2.78460495 |
| 41 | Cerebral hypomyelination (HP:0006808) | 2.74577721 |
| 42 | Hemiparesis (HP:0001269) | 2.72908933 |
| 43 | Polyphagia (HP:0002591) | 2.72649587 |
| 44 | Neuroendocrine neoplasm (HP:0100634) | 2.70318989 |
| 45 | Medial flaring of the eyebrow (HP:0010747) | 2.69290368 |
| 46 | Action tremor (HP:0002345) | 2.69022476 |
| 47 | Congenital primary aphakia (HP:0007707) | 2.66906630 |
| 48 | Nephrogenic diabetes insipidus (HP:0009806) | 2.65490509 |
| 49 | Fetal akinesia sequence (HP:0001989) | 2.64577062 |
| 50 | Failure to thrive in infancy (HP:0001531) | 2.61376178 |
| 51 | Sensory axonal neuropathy (HP:0003390) | 2.60497353 |
| 52 | Craniofacial dystonia (HP:0012179) | 2.60319939 |
| 53 | Diminished motivation (HP:0000745) | 2.58098010 |
| 54 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.57370556 |
| 55 | Dysdiadochokinesis (HP:0002075) | 2.56569941 |
| 56 | Ventricular fibrillation (HP:0001663) | 2.55362248 |
| 57 | Rigidity (HP:0002063) | 2.55178308 |
| 58 | Inability to walk (HP:0002540) | 2.53068085 |
| 59 | Insidious onset (HP:0003587) | 2.52017980 |
| 60 | Termporal pattern (HP:0011008) | 2.52017980 |
| 61 | EEG with generalized epileptiform discharges (HP:0011198) | 2.49354279 |
| 62 | Hyperthyroidism (HP:0000836) | 2.48425892 |
| 63 | Abnormal social behavior (HP:0012433) | 2.48253359 |
| 64 | Impaired social interactions (HP:0000735) | 2.48253359 |
| 65 | Absent speech (HP:0001344) | 2.46204635 |
| 66 | Clonus (HP:0002169) | 2.44814500 |
| 67 | Spastic tetraparesis (HP:0001285) | 2.44013456 |
| 68 | Depression (HP:0000716) | 2.39051228 |
| 69 | Poor suck (HP:0002033) | 2.37882127 |
| 70 | Blue irides (HP:0000635) | 2.35552310 |
| 71 | Impaired smooth pursuit (HP:0007772) | 2.34754296 |
| 72 | Hypsarrhythmia (HP:0002521) | 2.29823597 |
| 73 | Abnormality of the labia minora (HP:0012880) | 2.29328549 |
| 74 | Hypothermia (HP:0002045) | 2.28841465 |
| 75 | Oligomenorrhea (HP:0000876) | 2.28254467 |
| 76 | Impaired vibratory sensation (HP:0002495) | 2.27991666 |
| 77 | Abnormality of the corticospinal tract (HP:0002492) | 2.26442815 |
| 78 | Specific learning disability (HP:0001328) | 2.26096345 |
| 79 | Ankle clonus (HP:0011448) | 2.25193319 |
| 80 | Anxiety (HP:0000739) | 2.24941704 |
| 81 | Narrow nasal bridge (HP:0000446) | 2.21686476 |
| 82 | Limb dystonia (HP:0002451) | 2.19507756 |
| 83 | Ocular albinism (HP:0001107) | 2.18660548 |
| 84 | Rapidly progressive (HP:0003678) | 2.17621134 |
| 85 | CNS hypomyelination (HP:0003429) | 2.15939112 |
| 86 | Iris hypopigmentation (HP:0007730) | 2.12604261 |
| 87 | Choreoathetosis (HP:0001266) | 2.12093631 |
| 88 | Dysmetria (HP:0001310) | 2.12045068 |
| 89 | Scanning speech (HP:0002168) | 2.11949570 |
| 90 | Genetic anticipation (HP:0003743) | 2.10820980 |
| 91 | Akinesia (HP:0002304) | 2.10370121 |
| 92 | Hypoventilation (HP:0002791) | 2.10195679 |
| 93 | Abnormality of the lower motor neuron (HP:0002366) | 2.08948520 |
| 94 | Progressive inability to walk (HP:0002505) | 2.07471834 |
| 95 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.06436898 |
| 96 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.06436898 |
| 97 | Acute necrotizing encephalopathy (HP:0006965) | 2.04796656 |
| 98 | Urinary urgency (HP:0000012) | 2.02924055 |
| 99 | Spastic gait (HP:0002064) | 2.01679403 |
| 100 | Poor coordination (HP:0002370) | 2.01489027 |
| 101 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.01292559 |
| 102 | Genital tract atresia (HP:0001827) | 2.00793783 |
| 103 | Abnormality of salivation (HP:0100755) | 2.00601849 |
| 104 | Stereotypic behavior (HP:0000733) | 2.00127862 |
| 105 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.99483310 |
| 106 | Abnormality of binocular vision (HP:0011514) | 1.99015000 |
| 107 | Diplopia (HP:0000651) | 1.99015000 |
| 108 | Vaginal atresia (HP:0000148) | 1.97910243 |
| 109 | Incomplete penetrance (HP:0003829) | 1.95465651 |
| 110 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.95313825 |
| 111 | Absent/shortened dynein arms (HP:0200106) | 1.95313825 |
| 112 | Abnormality of pain sensation (HP:0010832) | 1.94586957 |
| 113 | Impaired pain sensation (HP:0007328) | 1.94586957 |
| 114 | Progressive macrocephaly (HP:0004481) | 1.94286818 |
| 115 | Abnormality of saccadic eye movements (HP:0000570) | 1.93536838 |
| 116 | Bradykinesia (HP:0002067) | 1.90993785 |
| 117 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.89662980 |
| 118 | Increased circulating renin level (HP:0000848) | 1.88620476 |
| 119 | Megalencephaly (HP:0001355) | 1.88132251 |
| 120 | Dementia (HP:0000726) | 1.87763560 |
| 121 | Delusions (HP:0000746) | 1.87281377 |
| 122 | Spinal canal stenosis (HP:0003416) | 1.86953749 |
| 123 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.86452357 |
| 124 | Resting tremor (HP:0002322) | 1.85307476 |
| 125 | Sleep apnea (HP:0010535) | 1.85297836 |
| 126 | Memory impairment (HP:0002354) | 1.84746107 |
| 127 | Gait ataxia (HP:0002066) | 1.84034648 |
| 128 | Supranuclear gaze palsy (HP:0000605) | 1.83194990 |
| 129 | Abnormal EKG (HP:0003115) | 1.83129041 |
| 130 | Esotropia (HP:0000565) | 1.82171395 |
| 131 | Spastic tetraplegia (HP:0002510) | 1.81097171 |
| 132 | Generalized myoclonic seizures (HP:0002123) | 1.78592975 |
| 133 | Torticollis (HP:0000473) | 1.78275104 |
| 134 | Lower limb muscle weakness (HP:0007340) | 1.78022906 |
| 135 | Status epilepticus (HP:0002133) | 1.77930632 |
| 136 | Postural instability (HP:0002172) | 1.77100469 |
| 137 | Bundle branch block (HP:0011710) | 1.76890677 |
| 138 | Prolonged QT interval (HP:0001657) | 1.76104399 |
| 139 | Global brain atrophy (HP:0002283) | 1.71255115 |
| 140 | Abnormality of the periventricular white matter (HP:0002518) | 1.70522741 |
| 141 | Slow saccadic eye movements (HP:0000514) | 1.69813544 |
| 142 | Insomnia (HP:0100785) | 1.69411966 |
| 143 | Postural tremor (HP:0002174) | 1.69063171 |
| 144 | Lower limb asymmetry (HP:0100559) | 1.68924643 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 7.27630638 |
| 2 | CDK19 | 3.30531460 |
| 3 | DAPK2 | 3.26172079 |
| 4 | MAP2K7 | 3.18528212 |
| 5 | MAP3K12 | 3.17760947 |
| 6 | EPHA4 | 3.11296276 |
| 7 | NTRK3 | 3.07308758 |
| 8 | MAP3K4 | 3.04849866 |
| 9 | AKT3 | 2.80624476 |
| 10 | PLK2 | 2.53820607 |
| 11 | DAPK1 | 2.32268132 |
| 12 | PRPF4B | 2.28521114 |
| 13 | CCNB1 | 2.27662513 |
| 14 | MARK1 | 2.00664784 |
| 15 | MINK1 | 1.98662896 |
| 16 | MAP2K4 | 1.95453448 |
| 17 | OXSR1 | 1.83235441 |
| 18 | MAP3K9 | 1.75097513 |
| 19 | SIK3 | 1.69656301 |
| 20 | MAPK13 | 1.68498959 |
| 21 | TAOK2 | 1.40049241 |
| 22 | SGK2 | 1.39822150 |
| 23 | CAMKK2 | 1.38802711 |
| 24 | GRK5 | 1.37646908 |
| 25 | RIPK1 | 1.30908733 |
| 26 | TYRO3 | 1.30691481 |
| 27 | SGK223 | 1.29150210 |
| 28 | SGK494 | 1.29150210 |
| 29 | NTRK2 | 1.28676369 |
| 30 | TSSK6 | 1.21714159 |
| 31 | PAK6 | 1.17798898 |
| 32 | BRAF | 1.13762310 |
| 33 | CDK5 | 1.11865479 |
| 34 | PRKCG | 1.10898396 |
| 35 | ARAF | 1.08201715 |
| 36 | LATS2 | 1.07544403 |
| 37 | KSR1 | 1.02466012 |
| 38 | BMPR2 | 1.00484195 |
| 39 | RIPK4 | 0.99660301 |
| 40 | CAMKK1 | 0.97675207 |
| 41 | PAK3 | 0.96201031 |
| 42 | CAMK2A | 0.95983991 |
| 43 | STK38 | 0.94594077 |
| 44 | TNIK | 0.92891317 |
| 45 | PKN1 | 0.89850556 |
| 46 | SGK3 | 0.83688670 |
| 47 | CAMK2B | 0.83230141 |
| 48 | PTK2B | 0.82315294 |
| 49 | NTRK1 | 0.82144339 |
| 50 | NEK6 | 0.80942618 |
| 51 | CDK18 | 0.78769671 |
| 52 | NME1 | 0.77273866 |
| 53 | BCR | 0.74117517 |
| 54 | MAP3K1 | 0.73763421 |
| 55 | SIK2 | 0.72343069 |
| 56 | MAP3K13 | 0.72035625 |
| 57 | DAPK3 | 0.70573305 |
| 58 | PDK3 | 0.70074937 |
| 59 | PDK4 | 0.70074937 |
| 60 | CDK15 | 0.69749269 |
| 61 | CDK14 | 0.69687957 |
| 62 | PRKCE | 0.68948766 |
| 63 | MAP3K11 | 0.67969239 |
| 64 | MAP2K6 | 0.67737080 |
| 65 | FGFR2 | 0.67412154 |
| 66 | ADRBK1 | 0.65015627 |
| 67 | ERBB3 | 0.64752662 |
| 68 | CDK11A | 0.58353367 |
| 69 | MAPK10 | 0.57246350 |
| 70 | KSR2 | 0.57206866 |
| 71 | FER | 0.56527937 |
| 72 | UHMK1 | 0.56201993 |
| 73 | ALK | 0.53783259 |
| 74 | PRKCZ | 0.53776205 |
| 75 | STK11 | 0.53770381 |
| 76 | SGK1 | 0.53759571 |
| 77 | CAMK1 | 0.53632567 |
| 78 | PHKG1 | 0.52702964 |
| 79 | PHKG2 | 0.52702964 |
| 80 | ADRBK2 | 0.52664358 |
| 81 | INSRR | 0.52448644 |
| 82 | FES | 0.51992989 |
| 83 | DYRK1A | 0.50454902 |
| 84 | LMTK2 | 0.49966247 |
| 85 | LIMK1 | 0.49961894 |
| 86 | TAOK1 | 0.49643957 |
| 87 | CDK3 | 0.48036383 |
| 88 | IRAK2 | 0.47392261 |
| 89 | MYLK | 0.46743239 |
| 90 | PRKD3 | 0.46438457 |
| 91 | FYN | 0.45301099 |
| 92 | CAMK4 | 0.44689116 |
| 93 | PRKCH | 0.44361093 |
| 94 | FGR | 0.43275953 |
| 95 | MAP3K6 | 0.43152782 |
| 96 | CAMK2D | 0.41243247 |
| 97 | GRK7 | 0.40825932 |
| 98 | TESK1 | 0.40418122 |
| 99 | PNCK | 0.40136173 |
| 100 | CAMK2G | 0.39768070 |
| 101 | TNK2 | 0.39292323 |
| 102 | MAPK12 | 0.38654141 |
| 103 | MAPK7 | 0.38457998 |
| 104 | PDK1 | 0.37764199 |
| 105 | YES1 | 0.37679722 |
| 106 | RPS6KA2 | 0.37537722 |
| 107 | CSNK1G2 | 0.37213986 |
| 108 | PDPK1 | 0.37128057 |
| 109 | BMPR1B | 0.34897633 |
| 110 | RET | 0.34844181 |
| 111 | MAP2K1 | 0.34182121 |
| 112 | BRSK1 | 0.33339404 |
| 113 | ROCK2 | 0.32277812 |
| 114 | PRKG2 | 0.32075509 |
| 115 | RPS6KB1 | 0.30399512 |
| 116 | JAK2 | 0.30133142 |
| 117 | PRKCA | 0.29379630 |
| 118 | DYRK2 | 0.28965182 |
| 119 | PRKCI | 0.28812319 |
| 120 | MAPK8 | 0.28395099 |
| 121 | PRKACA | 0.28336895 |
| 122 | WNK3 | 0.28201849 |
| 123 | MAP3K2 | 0.28155962 |
| 124 | MARK2 | 0.27854767 |
| 125 | PDK2 | 0.27544127 |
| 126 | CAMK1G | 0.27025735 |
| 127 | PRKG1 | 0.26923567 |
| 128 | WNK1 | 0.26310299 |
| 129 | RAF1 | 0.25493189 |
| 130 | PINK1 | 0.25023747 |
| 131 | RPS6KA3 | 0.24253405 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 4.44522109 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 4.17933868 |
| 3 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 3.21783270 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.91786274 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.81001569 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.54441335 |
| 7 | Morphine addiction_Homo sapiens_hsa05032 | 2.52450957 |
| 8 | Long-term potentiation_Homo sapiens_hsa04720 | 2.50885822 |
| 9 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.50785136 |
| 10 | GABAergic synapse_Homo sapiens_hsa04727 | 2.41875488 |
| 11 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.32823204 |
| 12 | Taste transduction_Homo sapiens_hsa04742 | 2.16329674 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.09657071 |
| 14 | Insulin secretion_Homo sapiens_hsa04911 | 2.06144168 |
| 15 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 2.05313621 |
| 16 | Salivary secretion_Homo sapiens_hsa04970 | 1.90611098 |
| 17 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.76103386 |
| 18 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.68985829 |
| 19 | Renin secretion_Homo sapiens_hsa04924 | 1.60863099 |
| 20 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.59250718 |
| 21 | Long-term depression_Homo sapiens_hsa04730 | 1.59206708 |
| 22 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.56956482 |
| 23 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.55633138 |
| 24 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.55504277 |
| 25 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.50694872 |
| 26 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.43477763 |
| 27 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.42240639 |
| 28 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.40156149 |
| 29 | Cocaine addiction_Homo sapiens_hsa05030 | 1.34043164 |
| 30 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.33103522 |
| 31 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.31672836 |
| 32 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.23694697 |
| 33 | Phototransduction_Homo sapiens_hsa04744 | 1.20854115 |
| 34 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.18542587 |
| 35 | Axon guidance_Homo sapiens_hsa04360 | 1.14026552 |
| 36 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.13096024 |
| 37 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.09954565 |
| 38 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.08182403 |
| 39 | Gap junction_Homo sapiens_hsa04540 | 1.08004031 |
| 40 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.06930653 |
| 41 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.05782702 |
| 42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.04671495 |
| 43 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.03026934 |
| 44 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.00115904 |
| 45 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.98405440 |
| 46 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.97063130 |
| 47 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.97017799 |
| 48 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.94254370 |
| 49 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.94105564 |
| 50 | Bile secretion_Homo sapiens_hsa04976 | 0.92266847 |
| 51 | Alzheimers disease_Homo sapiens_hsa05010 | 0.87629004 |
| 52 | Prion diseases_Homo sapiens_hsa05020 | 0.87151260 |
| 53 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.86921889 |
| 54 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.85793082 |
| 55 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.84751387 |
| 56 | Phagosome_Homo sapiens_hsa04145 | 0.82674588 |
| 57 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.82231079 |
| 58 | Melanogenesis_Homo sapiens_hsa04916 | 0.80049385 |
| 59 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.79935623 |
| 60 | Glioma_Homo sapiens_hsa05214 | 0.79062002 |
| 61 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.78598524 |
| 62 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.72356555 |
| 63 | Parkinsons disease_Homo sapiens_hsa05012 | 0.68361043 |
| 64 | Circadian rhythm_Homo sapiens_hsa04710 | 0.66564987 |
| 65 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.61840824 |
| 66 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.60846065 |
| 67 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.59106631 |
| 68 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.58440575 |
| 69 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.55614658 |
| 70 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.55308916 |
| 71 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.53860501 |
| 72 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.53361931 |
| 73 | Huntingtons disease_Homo sapiens_hsa05016 | 0.51394759 |
| 74 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.50641079 |
| 75 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.50597799 |
| 76 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.50244721 |
| 77 | Melanoma_Homo sapiens_hsa05218 | 0.48939234 |
| 78 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.48793404 |
| 79 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.48081004 |
| 80 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.48048654 |
| 81 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.47586720 |
| 82 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.47472309 |
| 83 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.47289559 |
| 84 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.47146079 |
| 85 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.42805273 |
| 86 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.41868978 |
| 87 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.39874038 |
| 88 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.39348751 |
| 89 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.39331409 |
| 90 | Alcoholism_Homo sapiens_hsa05034 | 0.39286051 |
| 91 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.37623017 |
| 92 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.37524269 |
| 93 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.36939741 |
| 94 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.36653713 |
| 95 | Mineral absorption_Homo sapiens_hsa04978 | 0.35996027 |
| 96 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.35813405 |
| 97 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.35694228 |
| 98 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.34959628 |
| 99 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.33950483 |
| 100 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.33927440 |
| 101 | Endometrial cancer_Homo sapiens_hsa05213 | 0.33257931 |
| 102 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.32921731 |
| 103 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.32200368 |
| 104 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.30125933 |
| 105 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.29179936 |
| 106 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.26097232 |
| 107 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.24721463 |
| 108 | ABC transporters_Homo sapiens_hsa02010 | 0.24388338 |
| 109 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.23961852 |
| 110 | Lysosome_Homo sapiens_hsa04142 | 0.23919215 |
| 111 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.23635605 |
| 112 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.23551058 |
| 113 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.22831658 |
| 114 | Endocytosis_Homo sapiens_hsa04144 | 0.22720098 |
| 115 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.22396042 |
| 116 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.21962228 |
| 117 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.19715178 |
| 118 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.19150627 |
| 119 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.19023293 |
| 120 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.18494266 |
| 121 | Colorectal cancer_Homo sapiens_hsa05210 | 0.18390360 |
| 122 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.15320692 |
| 123 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.13930363 |

