GOLGA8A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a family of proteins which are localized to the Golgi. This gene encodes a golgin which structurally resembles its family member GOLGA2, suggesting that they may share a similar function. There are many similar copies of this gene on chromosome 15. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of histone H3-K27 methylation (GO:0061085)5.14462880
2negative regulation of erythrocyte differentiation (GO:0045647)5.10032263
3histone H3-K4 trimethylation (GO:0080182)4.90556152
4histone H3-K9 demethylation (GO:0033169)4.84142276
5mannose metabolic process (GO:0006013)4.81102108
6positive regulation of CREB transcription factor activity (GO:0032793)4.38237685
7histone H3-K9 modification (GO:0061647)3.79687104
8negative thymic T cell selection (GO:0045060)3.77030364
9regulation of ARF protein signal transduction (GO:0032012)3.65308182
10stress granule assembly (GO:0034063)3.63358729
11negative T cell selection (GO:0043383)3.62676491
12thymic T cell selection (GO:0045061)3.58553296
13positive regulation of gamma-delta T cell activation (GO:0046645)3.56172192
14regulation of ARF GTPase activity (GO:0032312)3.56113330
15histone lysine demethylation (GO:0070076)3.55719271
16histone H3-K9 methylation (GO:0051567)3.48268132
17histone H3-K36 demethylation (GO:0070544)3.46623685
18histone demethylation (GO:0016577)3.37770474
19histone lysine methylation (GO:0034968)3.36859869
20histone H3-K4 methylation (GO:0051568)3.30352150
21positive T cell selection (GO:0043368)3.29501513
22positive thymic T cell selection (GO:0045059)3.29312129
23cerebellar Purkinje cell differentiation (GO:0021702)3.21487498
24regulation of gamma-delta T cell differentiation (GO:0045586)3.19114827
25positive regulation of dendritic spine morphogenesis (GO:0061003)3.18982207
26peptidyl-lysine trimethylation (GO:0018023)3.13507385
27negative regulation of histone methylation (GO:0031061)3.11746009
28peptidyl-lysine methylation (GO:0018022)3.10414785
29protein dealkylation (GO:0008214)3.07428883
30protein demethylation (GO:0006482)3.07428883
31positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.06927122
32regulation of RNA export from nucleus (GO:0046831)3.03651263
33response to muramyl dipeptide (GO:0032495)3.01350472
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00714941
35establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00466798
36mitochondrion transport along microtubule (GO:0047497)3.00466798
37Peyers patch development (GO:0048541)2.97969109
38mucosal-associated lymphoid tissue development (GO:0048537)2.97969109
39positive regulation of granulocyte differentiation (GO:0030854)2.97853733
40T cell selection (GO:0045058)2.97311918
41B cell receptor signaling pathway (GO:0050853)2.94111038
42positive regulation of histone deacetylation (GO:0031065)2.92910849
43poly(A)+ mRNA export from nucleus (GO:0016973)2.92558763
44regulation of gamma-delta T cell activation (GO:0046643)2.90422764
45positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.90385114
46positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.90355135
47mRNA splice site selection (GO:0006376)2.87832186
48positive regulation of synapse maturation (GO:0090129)2.86417472
49monoubiquitinated protein deubiquitination (GO:0035520)2.86037601
50layer formation in cerebral cortex (GO:0021819)2.84338852
51response to interleukin-15 (GO:0070672)2.83299529
52histone H4-K16 acetylation (GO:0043984)2.82619186
53interkinetic nuclear migration (GO:0022027)2.78198956
54histone H4 deacetylation (GO:0070933)2.77143222
55establishment of mitochondrion localization (GO:0051654)2.74897783
56CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73271770
57regulation of synapse maturation (GO:0090128)2.73139173
58histone methylation (GO:0016571)2.72839736
59histone deubiquitination (GO:0016578)2.72676092
60cerebellar granule cell differentiation (GO:0021707)2.72475634
61negative regulation of neurotransmitter secretion (GO:0046929)2.71636003
62regulation of histone methylation (GO:0031060)2.67422471
63regulation of histone H3-K4 methylation (GO:0051569)2.63901871
64definitive hemopoiesis (GO:0060216)2.61709498
65regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.61267184
66histone H3 deacetylation (GO:0070932)2.60254245
67microtubule nucleation (GO:0007020)2.59785232
68nuclear pore complex assembly (GO:0051292)2.57550648
69regulation of nucleobase-containing compound transport (GO:0032239)2.55616643
70positive regulation of dendrite morphogenesis (GO:0050775)2.53727498
71positive regulation of protein kinase C signaling (GO:0090037)2.53416905
72regulation of chromatin binding (GO:0035561)2.50680889
73natural killer cell differentiation (GO:0001779)2.48576982
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.46799937
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.45440089
76cell differentiation in hindbrain (GO:0021533)2.45098677
77phosphatidylinositol phosphorylation (GO:0046854)2.43339099
78head development (GO:0060322)2.42208678
79negative regulation of bone resorption (GO:0045779)2.41338668
80embryonic retina morphogenesis in camera-type eye (GO:0060059)2.40472127
81neuronal ion channel clustering (GO:0045161)2.38009060
82coronary vasculature morphogenesis (GO:0060977)2.37622266
83positive regulation of gene expression, epigenetic (GO:0045815)2.36431682
84positive regulation of B cell differentiation (GO:0045579)2.36353218
85response to epidermal growth factor (GO:0070849)2.35761652
86regulation of granulocyte differentiation (GO:0030852)2.34322299
87cell migration in hindbrain (GO:0021535)2.34064929
88camera-type eye morphogenesis (GO:0048593)2.33999028
89nerve growth factor signaling pathway (GO:0038180)2.33466035
90phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.33428877
91synaptic vesicle maturation (GO:0016188)2.31106837
92long-term memory (GO:0007616)2.30751338
93lipid phosphorylation (GO:0046834)2.30416076
94regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.30257709
95regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.29782833
96peripheral nervous system neuron development (GO:0048935)2.29641230
97glucocorticoid receptor signaling pathway (GO:0042921)2.28542369
98histone H4 acetylation (GO:0043967)2.27411096
99regulation of glutamate receptor signaling pathway (GO:1900449)2.26478042
100regulation of B cell receptor signaling pathway (GO:0050855)2.25878127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.52800840
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.46575820
3EZH2_22144423_ChIP-Seq_EOC_Human2.94658065
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.82018237
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75602468
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.68451521
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.64451079
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64371969
9DROSHA_22980978_ChIP-Seq_HELA_Human2.60342905
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.57701482
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.56136680
12KDM2B_26808549_Chip-Seq_DND41_Human2.48839428
13TCF7_22412390_ChIP-Seq_EML_Mouse2.40494366
14KDM2B_26808549_Chip-Seq_K562_Human2.28364071
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26731614
16KDM2B_26808549_Chip-Seq_JURKAT_Human2.16302339
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15392738
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.12408661
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12370290
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00920651
21EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.95252601
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86385104
23AR_21572438_ChIP-Seq_LNCaP_Human1.84996501
24RUNX_20019798_ChIP-Seq_JUKART_Human1.82374098
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79093600
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75727138
27MAF_26560356_Chip-Seq_TH1_Human1.74985774
28MAF_26560356_Chip-Seq_TH2_Human1.74801280
29GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.74102554
30CIITA_25753668_ChIP-Seq_RAJI_Human1.73243687
31VDR_21846776_ChIP-Seq_THP-1_Human1.73064605
32DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72438444
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71639825
34LXR_22292898_ChIP-Seq_THP-1_Human1.69908677
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69549046
36GATA1_19941826_ChIP-Seq_K562_Human1.61819729
37NCOR1_26117541_ChIP-Seq_K562_Human1.58287323
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57005840
39SMC4_20622854_ChIP-Seq_HELA_Human1.55678779
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54371147
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50850792
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50825681
43SCL_19346495_ChIP-Seq_HPC-7_Human1.49025756
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47298182
45CREB1_26743006_Chip-Seq_LNCaP_Human1.46487881
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41567656
47MYB_26560356_Chip-Seq_TH1_Human1.40876997
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40742258
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39011695
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38435678
51UTX_26944678_Chip-Seq_JUKART_Human1.32770672
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.25820369
53MYB_26560356_Chip-Seq_TH2_Human1.25643457
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.23216784
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22976814
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.21243542
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20742850
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.20464166
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20239329
60CTCF_27219007_Chip-Seq_Bcells_Human1.17505799
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17303350
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16980811
63REST_21632747_ChIP-Seq_MESCs_Mouse1.16583537
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15969590
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.15871752
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15719520
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.15453098
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14180971
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13065453
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13022169
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13022169
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12539012
73TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12077788
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11641786
75SPI1_23127762_ChIP-Seq_K562_Human1.10969246
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.09405952
77P68_20966046_ChIP-Seq_HELA_Human1.09049257
78GATA2_19941826_ChIP-Seq_K562_Human1.08819277
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07507121
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06591284
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.06247386
82MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04433573
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.03794530
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02772932
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02101883
86ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01463309
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00123521
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99008648
89WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97137255
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95312116
91OCT4_19829295_ChIP-Seq_ESCs_Human0.93693429
92* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92960420
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90988330
94AR_19668381_ChIP-Seq_PC3_Human0.90030873
95NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89786884
96SALL1_21062744_ChIP-ChIP_HESCs_Human0.88929206
97FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88264677
98REST_18959480_ChIP-ChIP_MESCs_Mouse0.88190662
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87602466
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87393301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.09841173
2MP0002396_abnormal_hematopoietic_system3.01250440
3MP0003763_abnormal_thymus_physiology2.76290994
4MP0001348_abnormal_lacrimal_gland2.65925235
5MP0008995_early_reproductive_senescence2.43501240
6MP0002822_catalepsy2.41530049
7MP0001502_abnormal_circadian_rhythm2.37252248
8MP0003787_abnormal_imprinting2.32410325
9MP0003122_maternal_imprinting2.25405155
10MP0008569_lethality_at_weaning2.15469429
11MP0002009_preneoplasia2.12776276
12MP0003635_abnormal_synaptic_transmissio2.05591184
13MP0004742_abnormal_vestibular_system2.02241201
14MP0005076_abnormal_cell_differentiation1.92768861
15MP0005423_abnormal_somatic_nervous1.92133445
16MP0000678_abnormal_parathyroid_gland1.84509027
17MP0002063_abnormal_learning/memory/cond1.82716711
18MP0005409_darkened_coat_color1.79264249
19MP0002735_abnormal_chemical_nociception1.76926878
20MP0002249_abnormal_larynx_morphology1.67254349
21MP0004270_analgesia1.58195827
22MP0008057_abnormal_DNA_replication1.54775827
23MP0004808_abnormal_hematopoietic_stem1.51874291
24MP0000703_abnormal_thymus_morphology1.51709565
25MP0001873_stomach_inflammation1.51283957
26MP0003172_abnormal_lysosome_physiology1.49944823
27MP0004885_abnormal_endolymph1.46669280
28MP0003123_paternal_imprinting1.41911517
29MP0003045_fibrosis1.40821044
30MP0000778_abnormal_nervous_system1.37683878
31MP0001800_abnormal_humoral_immune1.36607774
32MP0003121_genomic_imprinting1.36231604
33MP0001486_abnormal_startle_reflex1.35874336
34MP0008961_abnormal_basal_metabolism1.34474558
35MP0004043_abnormal_pH_regulation1.33109052
36MP0001501_abnormal_sleep_pattern1.26857058
37MP0002398_abnormal_bone_marrow1.25192197
38MP0003879_abnormal_hair_cell1.25071856
39MP0000955_abnormal_spinal_cord1.25020252
40MP0000003_abnormal_adipose_tissue1.23668123
41MP0005666_abnormal_adipose_tissue1.23311460
42MP0009278_abnormal_bone_marrow1.21697204
43MP0002064_seizures1.17603792
44MP0002572_abnormal_emotion/affect_behav1.11490093
45MP0002882_abnormal_neuron_morphology1.09071711
46MP0005645_abnormal_hypothalamus_physiol1.08349621
47MP0002184_abnormal_innervation1.07741170
48MP0005375_adipose_tissue_phenotype1.05302608
49MP0000685_abnormal_immune_system1.05041410
50MP0002557_abnormal_social/conspecific_i1.04210756
51MP0002933_joint_inflammation1.03932323
52MP0009115_abnormal_fat_cell1.03129200
53MP0003878_abnormal_ear_physiology1.00958367
54MP0005377_hearing/vestibular/ear_phenot1.00958367
55MP0004811_abnormal_neuron_physiology1.00940648
56MP0005671_abnormal_response_to1.00661166
57MP0009745_abnormal_behavioral_response0.97705778
58MP0000681_abnormal_thyroid_gland0.96456447
59MP0002166_altered_tumor_susceptibility0.96308304
60MP0001790_abnormal_immune_system0.95441234
61MP0005387_immune_system_phenotype0.95441234
62MP0001851_eye_inflammation0.92166873
63MP0003115_abnormal_respiratory_system0.89762136
64MP0003436_decreased_susceptibility_to0.87513006
65MP0003942_abnormal_urinary_system0.85563797
66MP0009046_muscle_twitch0.85453158
67MP0001943_abnormal_respiration0.85066612
68MP0002067_abnormal_sensory_capabilities0.84750960
69MP0000716_abnormal_immune_system0.84386356
70MP0001270_distended_abdomen0.83657432
71MP0003385_abnormal_body_wall0.83410280
72MP0002152_abnormal_brain_morphology0.82454410
73MP0003866_abnormal_defecation0.80957134
74MP0005220_abnormal_exocrine_pancreas0.80936458
75MP0002272_abnormal_nervous_system0.80261102
76MP0002734_abnormal_mechanical_nocicepti0.79587076
77MP0002722_abnormal_immune_system0.79162115
78MP0004145_abnormal_muscle_electrophysio0.78375993
79MP0004924_abnormal_behavior0.76647741
80MP0005386_behavior/neurological_phenoty0.76647741
81MP0002405_respiratory_system_inflammati0.76335855
82MP0003880_abnormal_central_pattern0.76097054
83MP0001177_atelectasis0.75802594
84MP0004381_abnormal_hair_follicle0.75052041
85MP0004185_abnormal_adipocyte_glucose0.74959843
86MP0002932_abnormal_joint_morphology0.74230877
87MP0001440_abnormal_grooming_behavior0.73747240
88MP0002723_abnormal_immune_serum0.73563449
89MP0003948_abnormal_gas_homeostasis0.73475757
90MP0005394_taste/olfaction_phenotype0.72540295
91MP0005499_abnormal_olfactory_system0.72540295
92MP0010768_mortality/aging0.72267976
93MP0003861_abnormal_nervous_system0.72156275
94MP0010769_abnormal_survival0.71613894
95MP0008775_abnormal_heart_ventricle0.70708934
96MP0010770_preweaning_lethality0.70602211
97MP0002082_postnatal_lethality0.70602211
98MP0002114_abnormal_axial_skeleton0.70526822
99MP0005000_abnormal_immune_tolerance0.69946795
100MP0002420_abnormal_adaptive_immunity0.69080889

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)4.43342997
2Abnormality of the fingertips (HP:0001211)3.64292396
3Heterotopia (HP:0002282)3.50096030
4Obstructive sleep apnea (HP:0002870)3.31538023
5Broad palm (HP:0001169)3.26920109
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.72075724
7Macroorchidism (HP:0000053)2.65515888
8Hypoplastic ischia (HP:0003175)2.59447709
9Abnormality of the ischium (HP:0003174)2.58901764
10Bell-shaped thorax (HP:0001591)2.48179294
11Ankyloglossia (HP:0010296)2.47215666
12Genetic anticipation (HP:0003743)2.46010646
13Vertebral arch anomaly (HP:0008438)2.35561743
14Turricephaly (HP:0000262)2.32561139
15Abnormality of cochlea (HP:0000375)2.26968859
16Truncus arteriosus (HP:0001660)2.25431256
17Pointed chin (HP:0000307)2.21141320
18Panhypogammaglobulinemia (HP:0003139)2.20528041
19Basal cell carcinoma (HP:0002671)2.19143908
20Bowel incontinence (HP:0002607)2.19018470
21Truncal obesity (HP:0001956)2.18941293
22Mild short stature (HP:0003502)2.15979070
23Dislocated radial head (HP:0003083)2.14494533
24Obsessive-compulsive behavior (HP:0000722)2.12839236
25Dysmetric saccades (HP:0000641)2.12058310
26Reticulocytosis (HP:0001923)2.11223800
27Colitis (HP:0002583)2.10121906
28Abnormality of the aortic arch (HP:0012303)2.08307017
29Seborrheic dermatitis (HP:0001051)2.06880964
30Agammaglobulinemia (HP:0004432)2.06567309
31Abnormality of the radial head (HP:0003995)2.06401573
32Cerebral aneurysm (HP:0004944)2.05578579
33Broad alveolar ridges (HP:0000187)2.03616372
34Menstrual irregularities (HP:0000858)2.02476957
3511 pairs of ribs (HP:0000878)2.00492019
36Trigonocephaly (HP:0000243)1.98767321
37Tapered finger (HP:0001182)1.98366920
38Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.97640892
39Alacrima (HP:0000522)1.97496274
40Febrile seizures (HP:0002373)1.95451725
41Cholecystitis (HP:0001082)1.95000018
42Abnormal gallbladder physiology (HP:0012438)1.95000018
43Hyperthyroidism (HP:0000836)1.94929641
44Sandal gap (HP:0001852)1.94466776
45Morphological abnormality of the inner ear (HP:0011390)1.94419985
46Atelectasis (HP:0100750)1.94352768
47Supernumerary ribs (HP:0005815)1.93127524
48Annular pancreas (HP:0001734)1.91371187
49Abnormality of incisor morphology (HP:0011063)1.89548992
50Biconcave vertebral bodies (HP:0004586)1.89506042
51Hyperacusis (HP:0010780)1.89122280
52Abnormality of oral frenula (HP:0000190)1.88049847
53Peripheral hypomyelination (HP:0007182)1.86376532
54Ankle clonus (HP:0011448)1.84883816
55Disproportionate tall stature (HP:0001519)1.84776727
56Spinal canal stenosis (HP:0003416)1.84649196
57Deep palmar crease (HP:0006191)1.83309377
58Vitreoretinal degeneration (HP:0000655)1.81942939
59Volvulus (HP:0002580)1.81722776
60Broad face (HP:0000283)1.81710913
61Abnormal large intestine physiology (HP:0012700)1.81479322
62Acute lymphatic leukemia (HP:0006721)1.80561146
63Epiphyseal dysplasia (HP:0002656)1.78296406
64Abnormality of the pubic bones (HP:0003172)1.76948725
65Abnormality of DNA repair (HP:0003254)1.76720898
66Morphological abnormality of the middle ear (HP:0008609)1.75982008
67Increased IgE level (HP:0003212)1.75562239
68Bronchomalacia (HP:0002780)1.74505121
69Decreased lacrimation (HP:0000633)1.72431369
70Epileptic encephalopathy (HP:0200134)1.70843989
71Long eyelashes (HP:0000527)1.70159950
72Stereotypic behavior (HP:0000733)1.69968617
73Acute myeloid leukemia (HP:0004808)1.69520662
74Hypoplastic iliac wings (HP:0002866)1.67884859
75Progressive cerebellar ataxia (HP:0002073)1.67725435
76Narrow palate (HP:0000189)1.67111020
77Abnormality of binocular vision (HP:0011514)1.67028786
78Diplopia (HP:0000651)1.67028786
79Hyperkalemia (HP:0002153)1.66673955
80Supernumerary bones of the axial skeleton (HP:0009144)1.65806789
81Neonatal short-limb short stature (HP:0008921)1.64540639
82Gastrointestinal stroma tumor (HP:0100723)1.62960774
83Cubitus valgus (HP:0002967)1.62493515
84Thickened helices (HP:0000391)1.62336312
85Recurrent sinusitis (HP:0011108)1.62073824
86Mitral valve prolapse (HP:0001634)1.62068387
87Urinary bladder sphincter dysfunction (HP:0002839)1.61153015
88Metaphyseal cupping (HP:0003021)1.60803715
89Abnormality of the wing of the ilium (HP:0011867)1.58919009
90Increased nuchal translucency (HP:0010880)1.58912673
91Thin ribs (HP:0000883)1.58897078
92Thick eyebrow (HP:0000574)1.58790069
93Hammertoe (HP:0001765)1.58124804
94Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.57960471
95Impaired smooth pursuit (HP:0007772)1.57541763
96Tracheomalacia (HP:0002779)1.56721300
97Wide nose (HP:0000445)1.56304729
98Onion bulb formation (HP:0003383)1.55206549
99Deeply set eye (HP:0000490)1.54621276
100Gastrointestinal inflammation (HP:0004386)1.54295233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK25.66692033
2CDK122.95123032
3PRPF4B2.70046984
4TRIB32.49846193
5MAP3K132.49674480
6FGFR42.40024591
7EEF2K2.34612812
8RIPK42.16344153
9NTRK32.07261485
10PKN22.02941978
11BRD41.97203760
12FGFR31.95156864
13NTRK21.83054702
14KSR21.76019215
15TYRO31.74542517
16MAP3K71.72824079
17MAP4K11.64433868
18CAMKK11.58593217
19WNK11.52740089
20MAP3K101.50906038
21FGFR21.46713813
22SIK11.37621124
23TAOK31.36414165
24PRKD31.30622723
25ITK1.27940972
26MARK21.26153338
27NEK21.22319182
28ICK1.18070034
29MARK11.12945772
30RET1.12237038
31NTRK11.05001872
32SIK31.01649150
33PRKCH1.00083227
34BTK0.99728862
35AKT30.95120955
36CDC42BPA0.93890034
37MTOR0.91962681
38RIPK10.89755916
39MAP3K140.88167022
40JAK10.87399949
41WNK40.87241572
42UHMK10.87134969
43TNIK0.86932888
44LATS10.84729234
45RAF10.82746104
46MAPK150.82613542
47SGK20.81878625
48PDGFRA0.81719611
49MAP3K20.81674486
50SGK4940.78999768
51SGK2230.78999768
52PASK0.78545483
53MAPK120.75717501
54MAPK110.74786724
55TYK20.74138567
56MAP2K60.73776215
57MAP3K90.73283136
58MAPK100.71912919
59PDK10.71453961
60CAMK1G0.71313302
61TRPM70.71091491
62TNK20.70946514
63TEC0.70338801
64SYK0.69671565
65SGK30.68449118
66KSR10.67862181
67CDK40.66718050
68JAK20.64238386
69HCK0.62743125
70HIPK20.62677274
71SGK10.61286467
72FLT30.59034513
73RPS6KA20.57871901
74MARK30.57754037
75FES0.56480103
76MAPK70.56267931
77STK380.54758528
78CDK30.51058341
79DYRK1A0.50305916
80JAK30.49896270
81MAP3K60.47578209
82PDGFRB0.46131036
83LCK0.45915470
84PDPK10.45492406
85FGFR10.44761145
86ERN10.43854919
87MAPK80.43173789
88MAPK30.42482154
89DAPK20.42386269
90EPHA30.42365339
91CAMK1D0.42011236
92RPS6KB10.41905461
93MAPK130.41657669
94EPHB10.40581553
95DDR20.40569877
96PAK60.40413079
97MAPK10.40005087
98GSK3B0.39999025
99CDK50.39057753
100NEK60.38099356

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046621.82908590
2Long-term potentiation_Homo sapiens_hsa047201.72280896
3Acute myeloid leukemia_Homo sapiens_hsa052211.69659194
4T cell receptor signaling pathway_Homo sapiens_hsa046601.64414294
5Dorso-ventral axis formation_Homo sapiens_hsa043201.61325628
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60181041
7Non-small cell lung cancer_Homo sapiens_hsa052231.56633059
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56562098
9Chronic myeloid leukemia_Homo sapiens_hsa052201.55813830
10ErbB signaling pathway_Homo sapiens_hsa040121.52546196
11Choline metabolism in cancer_Homo sapiens_hsa052311.52396951
12mTOR signaling pathway_Homo sapiens_hsa041501.51893653
13VEGF signaling pathway_Homo sapiens_hsa043701.50740332
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.49763814
15Nicotine addiction_Homo sapiens_hsa050331.41537861
16GnRH signaling pathway_Homo sapiens_hsa049121.39550182
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36828331
18Primary immunodeficiency_Homo sapiens_hsa053401.32585600
19Type II diabetes mellitus_Homo sapiens_hsa049301.30561441
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29608428
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.28499352
22Prolactin signaling pathway_Homo sapiens_hsa049171.25660554
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.25170134
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23846408
25Phospholipase D signaling pathway_Homo sapiens_hsa040721.22848438
26Notch signaling pathway_Homo sapiens_hsa043301.20849310
27Cholinergic synapse_Homo sapiens_hsa047251.20312415
28Glioma_Homo sapiens_hsa052141.18776992
29Pancreatic cancer_Homo sapiens_hsa052121.18385545
30Lysine degradation_Homo sapiens_hsa003101.17495584
31Renal cell carcinoma_Homo sapiens_hsa052111.17469459
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.16726727
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14696858
34Circadian entrainment_Homo sapiens_hsa047131.13681130
35Inositol phosphate metabolism_Homo sapiens_hsa005621.12440670
36Other glycan degradation_Homo sapiens_hsa005111.12109910
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10261162
38Estrogen signaling pathway_Homo sapiens_hsa049151.08497177
39Glutamatergic synapse_Homo sapiens_hsa047241.08051923
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07366971
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06884501
42Endometrial cancer_Homo sapiens_hsa052131.04152760
43Amphetamine addiction_Homo sapiens_hsa050311.02915772
44Autoimmune thyroid disease_Homo sapiens_hsa053201.02318873
45Allograft rejection_Homo sapiens_hsa053301.01216670
46Colorectal cancer_Homo sapiens_hsa052100.98536336
47HIF-1 signaling pathway_Homo sapiens_hsa040660.92743765
48mRNA surveillance pathway_Homo sapiens_hsa030150.91754613
49ABC transporters_Homo sapiens_hsa020100.90026230
50Thyroid hormone synthesis_Homo sapiens_hsa049180.89209372
51Oxytocin signaling pathway_Homo sapiens_hsa049210.86710690
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.86617211
53MAPK signaling pathway_Homo sapiens_hsa040100.86596985
54Morphine addiction_Homo sapiens_hsa050320.86303774
55Insulin secretion_Homo sapiens_hsa049110.84633933
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84337311
57Long-term depression_Homo sapiens_hsa047300.83449712
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82591963
59Insulin signaling pathway_Homo sapiens_hsa049100.82153964
60Graft-versus-host disease_Homo sapiens_hsa053320.79709247
61Hepatitis B_Homo sapiens_hsa051610.79641777
62Measles_Homo sapiens_hsa051620.79212211
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78438355
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78139859
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77773845
66Leishmaniasis_Homo sapiens_hsa051400.77003196
67MicroRNAs in cancer_Homo sapiens_hsa052060.76401323
68cAMP signaling pathway_Homo sapiens_hsa040240.76004573
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75589499
70Taste transduction_Homo sapiens_hsa047420.75134543
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.75134508
72Asthma_Homo sapiens_hsa053100.73867739
73Cocaine addiction_Homo sapiens_hsa050300.73174410
74Prostate cancer_Homo sapiens_hsa052150.73068543
75Insulin resistance_Homo sapiens_hsa049310.72639132
76Circadian rhythm_Homo sapiens_hsa047100.72573477
77Toxoplasmosis_Homo sapiens_hsa051450.72019159
78GABAergic synapse_Homo sapiens_hsa047270.71252900
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.71150032
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.70968406
81FoxO signaling pathway_Homo sapiens_hsa040680.70897486
82Dopaminergic synapse_Homo sapiens_hsa047280.70802931
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68485721
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66097881
85Influenza A_Homo sapiens_hsa051640.65680686
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65599653
87Ras signaling pathway_Homo sapiens_hsa040140.65133779
88Melanogenesis_Homo sapiens_hsa049160.64584754
89Platelet activation_Homo sapiens_hsa046110.64392431
90Renin secretion_Homo sapiens_hsa049240.63125660
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.62460035
92Gastric acid secretion_Homo sapiens_hsa049710.62390187
93Herpes simplex infection_Homo sapiens_hsa051680.62374044
94TNF signaling pathway_Homo sapiens_hsa046680.61791979
95Olfactory transduction_Homo sapiens_hsa047400.61190261
96Salivary secretion_Homo sapiens_hsa049700.60958322
97Chemokine signaling pathway_Homo sapiens_hsa040620.60153572
98Type I diabetes mellitus_Homo sapiens_hsa049400.60126962
99HTLV-I infection_Homo sapiens_hsa051660.59285358
100Small cell lung cancer_Homo sapiens_hsa052220.58874616

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »