GOLGA8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative thymic T cell selection (GO:0045060)5.64012482
2negative T cell selection (GO:0043383)5.47702760
3thymic T cell selection (GO:0045061)5.32414519
4positive thymic T cell selection (GO:0045059)5.09513452
5positive regulation of gamma-delta T cell activation (GO:0046645)4.96648201
6positive T cell selection (GO:0043368)4.82695941
7regulation of histone H3-K27 methylation (GO:0061085)4.68068161
8T cell selection (GO:0045058)4.50695443
9mannose metabolic process (GO:0006013)4.35744797
10regulation of gamma-delta T cell differentiation (GO:0045586)4.33798824
11histone H3-K4 trimethylation (GO:0080182)4.28421015
12positive regulation of CREB transcription factor activity (GO:0032793)4.28397574
13response to interleukin-15 (GO:0070672)4.20646317
14negative regulation of erythrocyte differentiation (GO:0045647)4.11188718
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.04923051
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.98919388
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.96620135
18B cell receptor signaling pathway (GO:0050853)3.91979675
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.91429390
20negative regulation of cell killing (GO:0031342)3.91429390
21regulation of gamma-delta T cell activation (GO:0046643)3.88181153
22histone H3-K9 demethylation (GO:0033169)3.80866089
23negative regulation of T-helper cell differentiation (GO:0045623)3.79815641
24negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.79815641
25positive regulation of granulocyte differentiation (GO:0030854)3.79344670
26histone H3-K36 demethylation (GO:0070544)3.77619805
27tolerance induction (GO:0002507)3.72801562
28antigen processing and presentation of endogenous antigen (GO:0019883)3.67769180
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52522012
30activated T cell proliferation (GO:0050798)3.51031234
31regulation of B cell receptor signaling pathway (GO:0050855)3.50557973
32histone H3-K9 modification (GO:0061647)3.37398205
33positive regulation of B cell differentiation (GO:0045579)3.25807345
34regulation of ARF protein signal transduction (GO:0032012)3.25453663
35Peyers patch development (GO:0048541)3.24137543
36mucosal-associated lymphoid tissue development (GO:0048537)3.24137543
37histone lysine demethylation (GO:0070076)3.23897843
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.21298148
39negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19285704
40cellular response to interleukin-15 (GO:0071350)3.19004488
41regulation of B cell differentiation (GO:0045577)3.17677355
42T cell migration (GO:0072678)3.17599420
43cilium or flagellum-dependent cell motility (GO:0001539)3.15649516
44response to muramyl dipeptide (GO:0032495)3.15463321
45negative regulation of type 2 immune response (GO:0002829)3.08995026
46histone demethylation (GO:0016577)3.07893541
47regulation of ARF GTPase activity (GO:0032312)3.05361547
48negative regulation of bone resorption (GO:0045779)3.02951245
49positive regulation of Rap GTPase activity (GO:0032854)3.02386396
50histone H3 deacetylation (GO:0070932)2.98453560
51histone H3-K9 methylation (GO:0051567)2.97690365
52histone H3-K4 methylation (GO:0051568)2.96474571
53regulation of T-helper 1 cell differentiation (GO:0045625)2.93908965
54regulation of interleukin-2 biosynthetic process (GO:0045076)2.93859362
55B cell homeostasis (GO:0001782)2.92403888
56CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.91726084
57histone H4-K16 acetylation (GO:0043984)2.87326498
58regulation of granulocyte differentiation (GO:0030852)2.82997674
59antigen receptor-mediated signaling pathway (GO:0050851)2.82965678
60negative regulation of T cell mediated immunity (GO:0002710)2.80272002
61histone deubiquitination (GO:0016578)2.79971398
62peptidyl-lysine trimethylation (GO:0018023)2.79450365
63interkinetic nuclear migration (GO:0022027)2.78498462
64mRNA splice site selection (GO:0006376)2.78409168
65negative regulation of lymphocyte mediated immunity (GO:0002707)2.77115030
66peptidyl-lysine methylation (GO:0018022)2.74836183
67histone lysine methylation (GO:0034968)2.74829940
68regulation of isotype switching to IgG isotypes (GO:0048302)2.72645361
69histone H4 deacetylation (GO:0070933)2.70979378
70phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.69910424
71positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.68678354
72monoubiquitinated protein deubiquitination (GO:0035520)2.66919084
73protein demethylation (GO:0006482)2.66705120
74protein dealkylation (GO:0008214)2.66705120
75T cell receptor signaling pathway (GO:0050852)2.66592004
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.61893010
77natural killer cell differentiation (GO:0001779)2.61603375
78regulation of alpha-beta T cell proliferation (GO:0046640)2.61586241
79regulation of Rap GTPase activity (GO:0032317)2.59030417
80negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.58150654
81positive regulation of natural killer cell differentiation (GO:0032825)2.57862436
82positive regulation of alpha-beta T cell differentiation (GO:0046638)2.57624410
83positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57621272
84positive regulation of protein kinase C signaling (GO:0090037)2.57275010
85positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.54283623
86nephron epithelium morphogenesis (GO:0072088)2.53624548
87nephron tubule morphogenesis (GO:0072078)2.53624548
88negative regulation of histone methylation (GO:0031061)2.53350356
89regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.52711761
90negative regulation of immunoglobulin mediated immune response (GO:0002890)2.51336626
91negative regulation of B cell mediated immunity (GO:0002713)2.51336626
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.51169832
93germinal center formation (GO:0002467)2.50985123
94activation of protein kinase A activity (GO:0034199)2.50044053
95negative regulation of alpha-beta T cell differentiation (GO:0046639)2.49776103
96stress granule assembly (GO:0034063)2.49068006
97regulation of alpha-beta T cell differentiation (GO:0046637)2.48822339
98poly(A)+ mRNA export from nucleus (GO:0016973)2.46291036
99cerebellar Purkinje cell differentiation (GO:0021702)2.46086015
100regulation of regulatory T cell differentiation (GO:0045589)2.44681075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.58373708
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90362900
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.41078871
4MYC_22102868_ChIP-Seq_BL_Human3.16437101
5RUNX_20019798_ChIP-Seq_JUKART_Human3.15278856
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.07786259
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.66541122
8DROSHA_22980978_ChIP-Seq_HELA_Human2.53900320
9* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48324276
10AR_21572438_ChIP-Seq_LNCaP_Human2.44149369
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.39565302
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.38524948
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.29608171
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28387286
15* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.26258182
16TCF7_22412390_ChIP-Seq_EML_Mouse2.25688597
17KDM2B_26808549_Chip-Seq_DND41_Human2.20420125
18MAF_26560356_Chip-Seq_TH1_Human2.15384641
19* MYB_26560356_Chip-Seq_TH2_Human2.15287095
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14661394
21MAF_26560356_Chip-Seq_TH2_Human2.09482291
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06460577
23MYB_26560356_Chip-Seq_TH1_Human1.97277653
24VDR_21846776_ChIP-Seq_THP-1_Human1.95062665
25KDM2B_26808549_Chip-Seq_JURKAT_Human1.92576039
26UTX_26944678_Chip-Seq_JUKART_Human1.86557885
27CIITA_25753668_ChIP-Seq_RAJI_Human1.79939678
28EZH2_22144423_ChIP-Seq_EOC_Human1.79928871
29SCL_19346495_ChIP-Seq_HPC-7_Human1.77737315
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75440242
31GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59972803
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58376929
33GATA1_19941826_ChIP-Seq_K562_Human1.56705130
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56551888
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50976189
36LXR_22292898_ChIP-Seq_THP-1_Human1.50407881
37* KDM2B_26808549_Chip-Seq_K562_Human1.50119228
38GATA3_27048872_Chip-Seq_THYMUS_Human1.49207876
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46704630
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.46419114
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43235436
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39197573
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36967855
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35185468
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33589598
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.32068572
47SMC4_20622854_ChIP-Seq_HELA_Human1.30356593
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30198467
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.29844323
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.29161895
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23810839
52TP53_16413492_ChIP-PET_HCT116_Human1.19000257
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18363690
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17399677
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17035554
56CREB1_26743006_Chip-Seq_LNCaP_Human1.16626858
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15174441
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12704543
59SPI1_23127762_ChIP-Seq_K562_Human1.12579204
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11899938
61P68_20966046_ChIP-Seq_HELA_Human1.11858382
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10786205
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.09548311
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04253730
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04034819
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03655422
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03262864
68VDR_24763502_ChIP-Seq_THP-1_Human1.01308488
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00696486
70NCOR1_26117541_ChIP-Seq_K562_Human1.00384041
71ELK3_25401928_ChIP-Seq_HUVEC_Human0.99768437
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99181826
73TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96035548
74ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95068273
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94777869
76GATA2_19941826_ChIP-Seq_K562_Human0.93906850
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93365486
78MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90261210
79SA1_27219007_Chip-Seq_ERYTHROID_Human0.89739705
80CTCF_27219007_Chip-Seq_Bcells_Human0.89408291
81ELF1_20517297_ChIP-Seq_JURKAT_Human0.87613901
82STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87444477
83TP63_22573176_ChIP-Seq_HFKS_Human0.85688681
84CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84404685
85RXR_22108803_ChIP-Seq_LS180_Human0.84188234
86JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84047110
87EZH2_27294783_Chip-Seq_ESCs_Mouse0.83628008
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82601810
89BCL6_27268052_Chip-Seq_Bcells_Human0.82185436
90GATA3_26560356_Chip-Seq_TH2_Human0.82079119
91SUZ12_27294783_Chip-Seq_ESCs_Mouse0.81162125
92PHF8_20622854_ChIP-Seq_HELA_Human0.80504226
93RNF2_27304074_Chip-Seq_ESCs_Mouse0.80135269
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.80051120
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79129290
96MYC_27129775_Chip-Seq_CORNEA_Mouse0.79054406
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78591651
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77408954
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.77069874
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76817180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.21752829
2MP0001800_abnormal_humoral_immune2.95078129
3MP0008961_abnormal_basal_metabolism2.94266130
4MP0003172_abnormal_lysosome_physiology2.75900315
5MP0002396_abnormal_hematopoietic_system2.73991788
6MP0003436_decreased_susceptibility_to2.61552935
7MP0000685_abnormal_immune_system2.56376607
8MP0005671_abnormal_response_to2.43472119
9MP0001835_abnormal_antigen_presentation2.41865906
10MP0001873_stomach_inflammation2.39824845
11MP0001790_abnormal_immune_system2.36395887
12MP0005387_immune_system_phenotype2.36395887
13MP0001348_abnormal_lacrimal_gland2.30238724
14MP0000703_abnormal_thymus_morphology2.23179367
15MP0002933_joint_inflammation2.21854375
16MP0002398_abnormal_bone_marrow2.08685427
17MP0005360_urolithiasis2.04876570
18MP0002723_abnormal_immune_serum2.02432228
19MP0002405_respiratory_system_inflammati2.01527277
20MP0002009_preneoplasia1.96036735
21MP0002420_abnormal_adaptive_immunity1.95970337
22MP0001819_abnormal_immune_cell1.92066176
23MP0004859_abnormal_synaptic_plasticity1.89481560
24MP0000716_abnormal_immune_system1.85754081
25MP0004130_abnormal_muscle_cell1.84592247
26MP0005000_abnormal_immune_tolerance1.84495006
27MP0008995_early_reproductive_senescence1.79980827
28MP0001502_abnormal_circadian_rhythm1.77940454
29MP0008569_lethality_at_weaning1.75756056
30MP0002452_abnormal_antigen_presenting1.70480153
31MP0004947_skin_inflammation1.63702617
32MP0003866_abnormal_defecation1.57220118
33MP0002722_abnormal_immune_system1.56764443
34MP0001501_abnormal_sleep_pattern1.54674012
35MP0000689_abnormal_spleen_morphology1.49343362
36MP0004381_abnormal_hair_follicle1.45857058
37MP0002429_abnormal_blood_cell1.44372374
38MP0002166_altered_tumor_susceptibility1.44242031
39MP0001851_eye_inflammation1.43520177
40MP0009333_abnormal_splenocyte_physiolog1.42639262
41MP0002138_abnormal_hepatobiliary_system1.38027731
42MP0001270_distended_abdomen1.36206222
43MP0003122_maternal_imprinting1.29710139
44MP0010155_abnormal_intestine_physiology1.27598214
45MP0001986_abnormal_taste_sensitivity1.26216143
46MP0003252_abnormal_bile_duct1.22502054
47MP0005025_abnormal_response_to1.17938645
48MP0004742_abnormal_vestibular_system1.16817085
49MP0001958_emphysema1.14484829
50MP0004043_abnormal_pH_regulation1.14025953
51MP0009278_abnormal_bone_marrow1.08885012
52MP0002928_abnormal_bile_duct1.06611517
53MP0002063_abnormal_learning/memory/cond1.05892808
54MP0005220_abnormal_exocrine_pancreas1.05414976
55MP0002419_abnormal_innate_immunity1.01970637
56MP0003635_abnormal_synaptic_transmissio0.99235108
57MP0003787_abnormal_imprinting0.99109107
58MP0001853_heart_inflammation0.98566041
59MP0004808_abnormal_hematopoietic_stem0.97293690
60MP0000003_abnormal_adipose_tissue0.94609299
61MP0002132_abnormal_respiratory_system0.94206884
62MP0002822_catalepsy0.90772822
63MP0005076_abnormal_cell_differentiation0.89364845
64MP0003329_amyloid_beta_deposits0.87309538
65MP0002572_abnormal_emotion/affect_behav0.85897681
66MP0003656_abnormal_erythrocyte_physiolo0.85137120
67MP0009384_cardiac_valve_regurgitation0.85050164
68MP0010329_abnormal_lipoprotein_level0.83868699
69MP0002089_abnormal_postnatal_growth/wei0.81315908
70MP0003045_fibrosis0.81225128
71MP0005397_hematopoietic_system_phenotyp0.80888298
72MP0001545_abnormal_hematopoietic_system0.80888298
73MP0009115_abnormal_fat_cell0.79429352
74MP0003943_abnormal_hepatobiliary_system0.78495222
75MP0005365_abnormal_bile_salt0.77025449
76MP0005409_darkened_coat_color0.76968730
77MP0001845_abnormal_inflammatory_respons0.75758056
78MP0003091_abnormal_cell_migration0.75449910
79MP0005666_abnormal_adipose_tissue0.75188738
80MP0005464_abnormal_platelet_physiology0.74787901
81MP0005377_hearing/vestibular/ear_phenot0.73981927
82MP0003878_abnormal_ear_physiology0.73981927
83MP0008875_abnormal_xenobiotic_pharmacok0.71552982
84MP0000609_abnormal_liver_physiology0.71203850
85MP0001486_abnormal_startle_reflex0.71121255
86MP0005448_abnormal_energy_balance0.68835335
87MP0002064_seizures0.67137377
88MP0005310_abnormal_salivary_gland0.66707074
89MP0005423_abnormal_somatic_nervous0.63759694
90MP0002083_premature_death0.62307974
91MP0002136_abnormal_kidney_physiology0.62080672
92MP0005375_adipose_tissue_phenotype0.61925838
93MP0008057_abnormal_DNA_replication0.61247757
94MP0003300_gastrointestinal_ulcer0.60466712
95MP0002006_tumorigenesis0.60444903
96MP0005535_abnormal_body_temperature0.60339517
97MP0002998_abnormal_bone_remodeling0.60219216
98MP0005646_abnormal_pituitary_gland0.59604485
99MP0003690_abnormal_glial_cell0.59550693
100MP0002249_abnormal_larynx_morphology0.58602882

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)4.78443567
2Panhypogammaglobulinemia (HP:0003139)4.63466139
3Abnormality of the fingertips (HP:0001211)4.35279188
4Agammaglobulinemia (HP:0004432)4.02481851
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.75188046
6Colitis (HP:0002583)3.64116558
7Pustule (HP:0200039)3.15917409
8Obstructive sleep apnea (HP:0002870)2.96538928
9Gastrointestinal inflammation (HP:0004386)2.94771497
10Inflammation of the large intestine (HP:0002037)2.90329384
11Broad palm (HP:0001169)2.85062630
12Deep venous thrombosis (HP:0002625)2.82580961
13Basal cell carcinoma (HP:0002671)2.79588803
14Recurrent sinusitis (HP:0011108)2.65026322
15Dislocated radial head (HP:0003083)2.64472277
16Seborrheic dermatitis (HP:0001051)2.61135157
17Heterotopia (HP:0002282)2.58574563
18Recurrent bronchitis (HP:0002837)2.56035409
19Severe combined immunodeficiency (HP:0004430)2.56025930
20Abnormality of the radial head (HP:0003995)2.54642674
21Recurrent viral infections (HP:0004429)2.53985410
22Broad face (HP:0000283)2.50129781
23Recurrent fungal infections (HP:0002841)2.41739815
24Meningitis (HP:0001287)2.33443084
25Viral hepatitis (HP:0006562)2.32232308
26Abnormality of T cells (HP:0002843)2.30716699
27Gastrointestinal stroma tumor (HP:0100723)2.30278392
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.29355996
29T lymphocytopenia (HP:0005403)2.27872515
30Recurrent cutaneous fungal infections (HP:0011370)2.24476566
31Chronic mucocutaneous candidiasis (HP:0002728)2.24476566
32Chronic diarrhea (HP:0002028)2.22185728
33Gastrointestinal infarctions (HP:0005244)2.21810331
34Tapered finger (HP:0001182)2.19391379
35Abnormality of T cell physiology (HP:0011840)2.19361867
36Abnormality of T cell number (HP:0011839)2.18918527
37Emphysema (HP:0002097)2.17130735
38Prolonged bleeding time (HP:0003010)2.15952275
39Chronic otitis media (HP:0000389)2.15274598
40Recurrent otitis media (HP:0000403)2.13908002
41Hepatitis (HP:0012115)2.11772544
42Vasculitis (HP:0002633)2.11595261
43Supernumerary bones of the axial skeleton (HP:0009144)1.98923846
44Trigonocephaly (HP:0000243)1.94246307
45Verrucae (HP:0200043)1.91511676
46Papilloma (HP:0012740)1.91511676
47Supernumerary ribs (HP:0005815)1.90432145
48Pulmonary infiltrates (HP:0002113)1.89566625
49Overgrowth (HP:0001548)1.87993298
50Genetic anticipation (HP:0003743)1.87820638
51Autoimmune hemolytic anemia (HP:0001890)1.86683774
52IgG deficiency (HP:0004315)1.86673352
53Encephalitis (HP:0002383)1.85763025
54Hypoplastic ischia (HP:0003175)1.83089367
55Diplopia (HP:0000651)1.82726003
56Abnormality of binocular vision (HP:0011514)1.82726003
57Abnormality of cochlea (HP:0000375)1.81875587
58Biconcave vertebral bodies (HP:0004586)1.80587377
59Granulocytopenia (HP:0001913)1.80162852
60Spinal canal stenosis (HP:0003416)1.80038615
61Acute lymphatic leukemia (HP:0006721)1.77307177
62Increased IgE level (HP:0003212)1.77200758
63Broad alveolar ridges (HP:0000187)1.76009809
64Lymphopenia (HP:0001888)1.75823484
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74027152
66Febrile seizures (HP:0002373)1.73872044
67Hypoplasia of the thymus (HP:0000778)1.73816143
68Thick eyebrow (HP:0000574)1.72158345
69Bronchitis (HP:0012387)1.70982947
7011 pairs of ribs (HP:0000878)1.70813973
71Macroorchidism (HP:0000053)1.68632069
72Villous atrophy (HP:0011473)1.68452635
73Abnormality of small intestinal villus morphology (HP:0011472)1.68452635
74Myositis (HP:0100614)1.67747074
75Metaphyseal cupping (HP:0003021)1.67464295
76Abnormality of DNA repair (HP:0003254)1.66534354
77Abnormality of the ischium (HP:0003174)1.66178833
78Narrow palate (HP:0000189)1.66109977
79Dynein arm defect of respiratory motile cilia (HP:0012255)1.65639757
80Absent/shortened dynein arms (HP:0200106)1.65639757
81Flat acetabular roof (HP:0003180)1.63777427
82Deep palmar crease (HP:0006191)1.63387724
83Annular pancreas (HP:0001734)1.62686603
84Abnormality of the wing of the ilium (HP:0011867)1.62007875
85Abnormality of cells of the lymphoid lineage (HP:0012140)1.61917637
86Epileptic encephalopathy (HP:0200134)1.60210247
87Restrictive lung disease (HP:0002091)1.59822799
88Ureteral stenosis (HP:0000071)1.59420599
89Menorrhagia (HP:0000132)1.59388269
90Abnormality of the peritoneum (HP:0002585)1.58304076
91Clumsiness (HP:0002312)1.57792050
92Combined immunodeficiency (HP:0005387)1.57633259
93Abnormality of the humeroradial joint (HP:0100744)1.57610569
94Bell-shaped thorax (HP:0001591)1.57076176
95Neoplasm of the heart (HP:0100544)1.56750467
96Truncal obesity (HP:0001956)1.56461353
97Bronchiectasis (HP:0002110)1.55512213
98Joint swelling (HP:0001386)1.54975403
99IgM deficiency (HP:0002850)1.54972467
100Segmental peripheral demyelination/remyelination (HP:0003481)1.54868663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.06548642
2SIK23.56274486
3MAP3K133.32226874
4NTRK22.82568011
5TRIB32.59677652
6RIPK42.54670972
7CDK122.50450011
8TAOK32.42491944
9FGFR42.31912866
10TXK2.17758354
11FGFR31.93634964
12PRPF4B1.91991805
13MAP3K71.87653307
14ITK1.73332233
15MAP3K141.70405724
16TYRO31.63891206
17EEF2K1.57146270
18CAMKK11.56714240
19BRD41.51831140
20FGFR21.46998959
21ZAP701.44167156
22CDC42BPA1.43479823
23TYK21.41604153
24BTK1.39406974
25SYK1.38505295
26BLK1.33903176
27MAPK151.33245002
28MAP2K61.31420689
29WNK11.30553021
30PASK1.29195037
31JAK31.28237700
32JAK11.27810294
33MAP3K101.25102186
34MARK21.23597335
35FES1.18343342
36SIK11.08299603
37MAPK121.07185390
38TEC1.05599270
39TNK21.05091356
40NTRK31.01153181
41LCK0.98404891
42IKBKE0.97563371
43RET0.97273145
44GRK60.96687502
45ICK0.93397175
46MAPK110.90150955
47HCK0.86999757
48PKN20.86387606
49PDK10.86314554
50SIK30.83972965
51CDK40.80123365
52MAP2K30.78020590
53KSR20.77458118
54PRKCQ0.75460497
55HIPK20.74094239
56MAPK70.74054757
57ERN10.73705096
58DYRK1A0.72335576
59AKT30.71990768
60WNK40.69776971
61PIK3CA0.69429084
62NEK90.68906327
63MARK30.67799979
64SGK20.67523270
65PRKCH0.66383072
66TBK10.64213012
67CAMKK20.63761968
68PDGFRA0.63116390
69KIT0.61203863
70CSF1R0.59464870
71TRPM70.59018824
72JAK20.58350095
73SGK2230.58215790
74SGK4940.58215790
75MTOR0.56267582
76LYN0.56118532
77IKBKB0.53854679
78SGK30.53301640
79CHUK0.51068166
80PDGFRB0.50572327
81NLK0.50136384
82PDPK10.49930959
83UHMK10.48822802
84FLT30.48270229
85MELK0.48132551
86BMPR20.48107115
87RIPK10.48045040
88SGK10.47951481
89MAPK100.47093124
90NTRK10.46765839
91MAP3K20.46759551
92STK380.46612532
93CDK90.45764688
94MAP3K60.44106243
95MAPK30.44027304
96CSK0.43752512
97DAPK20.42937411
98CDK80.42452493
99CDK30.42276897
100MAP2K20.41553256

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.64356861
2B cell receptor signaling pathway_Homo sapiens_hsa046622.14752440
3T cell receptor signaling pathway_Homo sapiens_hsa046602.09665205
4Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74944503
5Autoimmune thyroid disease_Homo sapiens_hsa053201.64434521
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.63630404
7Other glycan degradation_Homo sapiens_hsa005111.62456967
8ABC transporters_Homo sapiens_hsa020101.61364722
9Graft-versus-host disease_Homo sapiens_hsa053321.56256258
10Phosphatidylinositol signaling system_Homo sapiens_hsa040701.55977253
11Allograft rejection_Homo sapiens_hsa053301.53558741
12Acute myeloid leukemia_Homo sapiens_hsa052211.51290908
13Non-small cell lung cancer_Homo sapiens_hsa052231.50264999
14VEGF signaling pathway_Homo sapiens_hsa043701.41993949
15Choline metabolism in cancer_Homo sapiens_hsa052311.41646383
16Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40185889
17GnRH signaling pathway_Homo sapiens_hsa049121.34431784
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.34061938
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33525696
20Dorso-ventral axis formation_Homo sapiens_hsa043201.28994145
21mTOR signaling pathway_Homo sapiens_hsa041501.26880065
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24979114
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21159570
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14825341
25Long-term potentiation_Homo sapiens_hsa047201.14134747
26Prolactin signaling pathway_Homo sapiens_hsa049171.13240204
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.12605092
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.12397153
29Inositol phosphate metabolism_Homo sapiens_hsa005621.12029101
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.11410487
31Platelet activation_Homo sapiens_hsa046111.10964828
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09973086
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08200139
34Type I diabetes mellitus_Homo sapiens_hsa049401.07989943
35Leishmaniasis_Homo sapiens_hsa051401.05804592
36Chronic myeloid leukemia_Homo sapiens_hsa052201.05677290
37Thyroid hormone synthesis_Homo sapiens_hsa049181.02416765
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01863438
39Measles_Homo sapiens_hsa051620.96936801
40Lysine degradation_Homo sapiens_hsa003100.94112301
41Toxoplasmosis_Homo sapiens_hsa051450.93766887
42Staphylococcus aureus infection_Homo sapiens_hsa051500.93560937
43Circadian rhythm_Homo sapiens_hsa047100.93500063
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.93455717
45Osteoclast differentiation_Homo sapiens_hsa043800.93229178
46Hematopoietic cell lineage_Homo sapiens_hsa046400.93144477
47MAPK signaling pathway_Homo sapiens_hsa040100.91179842
48ErbB signaling pathway_Homo sapiens_hsa040120.90946861
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.88959322
50Estrogen signaling pathway_Homo sapiens_hsa049150.88676447
51Notch signaling pathway_Homo sapiens_hsa043300.88606424
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87844840
53Insulin resistance_Homo sapiens_hsa049310.87291815
54Linoleic acid metabolism_Homo sapiens_hsa005910.87243985
55Olfactory transduction_Homo sapiens_hsa047400.86972662
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85301763
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84695945
58Type II diabetes mellitus_Homo sapiens_hsa049300.84409538
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83915932
60Asthma_Homo sapiens_hsa053100.83152399
61TNF signaling pathway_Homo sapiens_hsa046680.82846486
62Pancreatic cancer_Homo sapiens_hsa052120.81782836
63Cholinergic synapse_Homo sapiens_hsa047250.81455144
64Oxytocin signaling pathway_Homo sapiens_hsa049210.81118015
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80894896
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79599116
67Herpes simplex infection_Homo sapiens_hsa051680.79481177
68Influenza A_Homo sapiens_hsa051640.79248628
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78963603
70Amphetamine addiction_Homo sapiens_hsa050310.78446683
71Glutamatergic synapse_Homo sapiens_hsa047240.77448566
72Chemokine signaling pathway_Homo sapiens_hsa040620.76533871
73FoxO signaling pathway_Homo sapiens_hsa040680.76114209
74Complement and coagulation cascades_Homo sapiens_hsa046100.75166147
75Circadian entrainment_Homo sapiens_hsa047130.73751304
76Morphine addiction_Homo sapiens_hsa050320.72358540
77Hepatitis B_Homo sapiens_hsa051610.71447649
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.71192836
79Colorectal cancer_Homo sapiens_hsa052100.69661303
80Glioma_Homo sapiens_hsa052140.69108272
81Salivary secretion_Homo sapiens_hsa049700.68557908
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68097165
83Renal cell carcinoma_Homo sapiens_hsa052110.67931022
84Gastric acid secretion_Homo sapiens_hsa049710.67778255
85Antigen processing and presentation_Homo sapiens_hsa046120.67250282
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67204197
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.66884588
88Cocaine addiction_Homo sapiens_hsa050300.66655467
89Ovarian steroidogenesis_Homo sapiens_hsa049130.65345050
90Endometrial cancer_Homo sapiens_hsa052130.65202433
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65155512
92Taste transduction_Homo sapiens_hsa047420.64975098
93Insulin secretion_Homo sapiens_hsa049110.63852854
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63554257
95Calcium signaling pathway_Homo sapiens_hsa040200.63119292
96Bile secretion_Homo sapiens_hsa049760.62664064
97HTLV-I infection_Homo sapiens_hsa051660.60265489
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60174118
99Pancreatic secretion_Homo sapiens_hsa049720.59308012
100Ether lipid metabolism_Homo sapiens_hsa005650.58625174

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