GOLGA8CP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)8.42949430
2cilium movement (GO:0003341)7.85288882
3axonemal dynein complex assembly (GO:0070286)7.74558725
4retinal cone cell development (GO:0046549)7.16649773
5negative regulation of cytosolic calcium ion concentration (GO:0051481)6.37527434
6cilium or flagellum-dependent cell motility (GO:0001539)6.28054758
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.19198304
8axoneme assembly (GO:0035082)5.96434975
9motile cilium assembly (GO:0044458)5.93799673
10regulation of translational termination (GO:0006449)5.73959978
11protein polyglutamylation (GO:0018095)5.14584089
12protein localization to cilium (GO:0061512)4.91872685
13opioid receptor signaling pathway (GO:0038003)4.78680680
14ether lipid metabolic process (GO:0046485)4.57515625
15negative regulation of thymocyte apoptotic process (GO:0070244)4.47175532
16negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.44985503
17behavioral response to ethanol (GO:0048149)4.44782451
18retinal rod cell development (GO:0046548)4.38311173
19thrombin receptor signaling pathway (GO:0070493)4.33588566
20ventricular system development (GO:0021591)4.33435564
21DNA replication-dependent nucleosome assembly (GO:0006335)4.26174754
22DNA replication-dependent nucleosome organization (GO:0034723)4.26174754
23ADP metabolic process (GO:0046031)4.22260030
24piRNA metabolic process (GO:0034587)4.16096412
25regulation of acrosome reaction (GO:0060046)4.07695644
26RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.96955435
27phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.91519513
28cilium morphogenesis (GO:0060271)3.89500743
29myelin assembly (GO:0032288)3.83576611
30left/right axis specification (GO:0070986)3.83081622
31regulation of regulatory T cell differentiation (GO:0045589)3.75985246
32kynurenine metabolic process (GO:0070189)3.70521238
33negative regulation of cAMP-mediated signaling (GO:0043951)3.60713455
34protein kinase C signaling (GO:0070528)3.58383743
35negative regulation of T-helper cell differentiation (GO:0045623)3.46229338
36negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.46229338
37histone H4-K12 acetylation (GO:0043983)3.44986402
38regulation of protein glycosylation (GO:0060049)3.41833019
39cilium organization (GO:0044782)3.41774943
40intraciliary transport (GO:0042073)3.41013062
41protein complex biogenesis (GO:0070271)3.38904077
42histone H2A ubiquitination (GO:0033522)3.37390363
43tryptophan catabolic process (GO:0006569)3.35223499
44indole-containing compound catabolic process (GO:0042436)3.35223499
45indolalkylamine catabolic process (GO:0046218)3.35223499
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33226022
47histone H2A monoubiquitination (GO:0035518)3.30661217
48regulation of establishment or maintenance of cell polarity (GO:0032878)3.27846974
49nucleoside diphosphate phosphorylation (GO:0006165)3.22881885
50adult feeding behavior (GO:0008343)3.21745433
51mitochondrial respiratory chain complex assembly (GO:0033108)3.18431243
52replication fork processing (GO:0031297)3.18160451
53nucleotide transmembrane transport (GO:1901679)3.15313051
54neural tube formation (GO:0001841)3.11995525
55negative regulation of cell killing (GO:0031342)3.10955049
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10955049
57indolalkylamine metabolic process (GO:0006586)3.09364458
58sperm motility (GO:0030317)3.04709116
59histamine secretion (GO:0001821)3.03591407
60DNA excision (GO:0044349)2.97858015
61nucleotide-excision repair, DNA damage removal (GO:0000718)2.97858015
62glycerophospholipid catabolic process (GO:0046475)2.92923679
63negative regulation of alpha-beta T cell differentiation (GO:0046639)2.88723553
64cilium assembly (GO:0042384)2.87287658
65S-adenosylmethionine metabolic process (GO:0046500)2.85289091
66positive regulation of alpha-beta T cell proliferation (GO:0046641)2.84542222
67NADH dehydrogenase complex assembly (GO:0010257)2.83791943
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83791943
69mitochondrial respiratory chain complex I assembly (GO:0032981)2.83791943
70histone exchange (GO:0043486)2.82954069
71regulation of T-helper 1 cell differentiation (GO:0045625)2.82156683
72quinone biosynthetic process (GO:1901663)2.81168602
73ubiquinone biosynthetic process (GO:0006744)2.80768947
74regulation of memory T cell differentiation (GO:0043380)2.79729241
75behavioral response to nicotine (GO:0035095)2.79224749
76positive regulation of steroid hormone secretion (GO:2000833)2.76547410
77detection of mechanical stimulus involved in sensory perception (GO:0050974)2.76039292
78auditory receptor cell stereocilium organization (GO:0060088)2.73066656
79cellular component assembly involved in morphogenesis (GO:0010927)2.72536311
80maturation of 5.8S rRNA (GO:0000460)2.68710084
81response to misfolded protein (GO:0051788)2.66438545
82primary amino compound metabolic process (GO:1901160)2.65768640
83adaptation of signaling pathway (GO:0023058)2.65510546
84pyrimidine dimer repair (GO:0006290)2.65490852
85tryptophan metabolic process (GO:0006568)2.64119434
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63297266
87centriole replication (GO:0007099)2.62878117
88determination of left/right symmetry (GO:0007368)2.62540143
89positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.62329749
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60568274
91negative regulation of nitric oxide biosynthetic process (GO:0045019)2.60399151
92negative regulation of neurological system process (GO:0031645)2.60196617
93positive regulation of cAMP-mediated signaling (GO:0043950)2.60166739
94thyroid hormone metabolic process (GO:0042403)2.59260883
95sphingoid metabolic process (GO:0046519)2.56240334
96indole-containing compound metabolic process (GO:0042430)2.55070244
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54758164
98negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.54421797
99left/right pattern formation (GO:0060972)2.53742289
100preassembly of GPI anchor in ER membrane (GO:0016254)2.53687809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.86750048
2EZH2_22144423_ChIP-Seq_EOC_Human3.72706864
3VDR_22108803_ChIP-Seq_LS180_Human3.50715959
4GBX2_23144817_ChIP-Seq_PC3_Human3.23740216
5IGF1R_20145208_ChIP-Seq_DFB_Human2.73351050
6ZNF274_21170338_ChIP-Seq_K562_Hela2.69085320
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48718189
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.47494760
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47037073
10E2F7_22180533_ChIP-Seq_HELA_Human2.45542999
11EWS_26573619_Chip-Seq_HEK293_Human2.43379013
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34556867
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.34556867
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20564326
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18886759
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.07793181
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.99950925
18CBP_20019798_ChIP-Seq_JUKART_Human1.91082544
19IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.91082544
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91070085
21FUS_26573619_Chip-Seq_HEK293_Human1.90052107
22AR_21572438_ChIP-Seq_LNCaP_Human1.89650141
23STAT3_23295773_ChIP-Seq_U87_Human1.85672217
24ER_23166858_ChIP-Seq_MCF-7_Human1.76025224
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69888097
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67523329
27TCF4_23295773_ChIP-Seq_U87_Human1.66637638
28TAF15_26573619_Chip-Seq_HEK293_Human1.58796437
29BCAT_22108803_ChIP-Seq_LS180_Human1.58512681
30P300_19829295_ChIP-Seq_ESCs_Human1.58433254
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57896136
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57555764
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57209821
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55321189
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46132941
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.44512687
37RNF2_27304074_Chip-Seq_NSC_Mouse1.42066840
38NANOG_19829295_ChIP-Seq_ESCs_Human1.41024838
39SOX2_19829295_ChIP-Seq_ESCs_Human1.41024838
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40956362
41SMAD4_21799915_ChIP-Seq_A2780_Human1.40774127
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40602546
43CDX2_22108803_ChIP-Seq_LS180_Human1.39055424
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38967284
45RXR_22108803_ChIP-Seq_LS180_Human1.37436377
46STAT1_20625510_ChIP-Seq_HELA_Human1.37352956
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33228905
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28301693
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.28301693
50MYC_18940864_ChIP-ChIP_HL60_Human1.28225839
51SCL_19346495_ChIP-Seq_HPC-7_Human1.28197600
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.27286153
53TCF4_22108803_ChIP-Seq_LS180_Human1.26519716
54CEBPB_22108803_ChIP-Seq_LS180_Human1.25274949
55IRF1_19129219_ChIP-ChIP_H3396_Human1.24682762
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.23907318
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.23429527
58DROSHA_22980978_ChIP-Seq_HELA_Human1.23416963
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21073796
60TP53_22573176_ChIP-Seq_HFKS_Human1.20185290
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.19708278
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19434761
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18947977
64NFYB_21822215_ChIP-Seq_K562_Human1.18589922
65RUNX2_22187159_ChIP-Seq_PCA_Human1.18576316
66AR_20517297_ChIP-Seq_VCAP_Human1.18432552
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17828993
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16168002
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14215172
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14139614
71SMRT_27268052_Chip-Seq_Bcells_Human1.12547988
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.12102184
73NCOR_22424771_ChIP-Seq_293T_Human1.09833625
74TBL1_22424771_ChIP-Seq_293T_Human1.09372629
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.08797504
76AR_25329375_ChIP-Seq_VCAP_Human1.06901419
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.05981519
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05464508
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04980497
80ETV1_20927104_ChIP-Seq_GIST48_Human1.04540879
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03575630
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.03457629
83OCT1_27270436_Chip-Seq_PROSTATE_Human1.03245826
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.03232625
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02566227
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02548751
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02362385
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.01855380
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00994337
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00252992
91PHF8_20622853_ChIP-Seq_HELA_Human0.98778169
92JUN_21703547_ChIP-Seq_K562_Human0.98429384
93RBPJ_21746931_ChIP-Seq_IB4_Human0.96968427
94STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96391484
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95900386
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95187933
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94285523
98NFYA_21822215_ChIP-Seq_K562_Human0.93546979
99OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92897206
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92087586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005167_abnormal_blood-brain_barrier4.05004811
2MP0003045_fibrosis3.61120801
3MP0005075_abnormal_melanosome_morpholog3.43166825
4MP0003787_abnormal_imprinting3.29826365
5MP0002876_abnormal_thyroid_physiology3.24354569
6MP0003646_muscle_fatigue3.06213845
7MP0005646_abnormal_pituitary_gland2.84264375
8MP0009278_abnormal_bone_marrow2.80286908
9MP0000678_abnormal_parathyroid_gland2.78405224
10MP0001968_abnormal_touch/_nociception2.44157933
11MP0005360_urolithiasis2.38548872
12MP0003879_abnormal_hair_cell2.35345760
13MP0001501_abnormal_sleep_pattern2.33123913
14MP0005551_abnormal_eye_electrophysiolog2.21576389
15MP0000566_synostosis2.16109414
16MP0008057_abnormal_DNA_replication2.11833616
17MP0008877_abnormal_DNA_methylation2.08331382
18MP0003806_abnormal_nucleotide_metabolis2.04172982
19MP0008775_abnormal_heart_ventricle2.03719277
20MP0006035_abnormal_mitochondrial_morpho1.97308497
21MP0009780_abnormal_chondrocyte_physiolo1.93020391
22MP0005503_abnormal_tendon_morphology1.74871705
23MP0003195_calcinosis1.66620016
24MP0002234_abnormal_pharynx_morphology1.58308878
25MP0002160_abnormal_reproductive_system1.56665131
26MP0009697_abnormal_copulation1.53447088
27MP0005389_reproductive_system_phenotype1.52622496
28MP0009046_muscle_twitch1.51014021
29MP0001919_abnormal_reproductive_system1.50475580
30MP0010368_abnormal_lymphatic_system1.48282723
31MP0010094_abnormal_chromosome_stability1.47274365
32MP0006036_abnormal_mitochondrial_physio1.45735758
33MP0003718_maternal_effect1.45308713
34MP0003959_abnormal_lean_body1.42164589
35MP0003633_abnormal_nervous_system1.42107865
36MP0004142_abnormal_muscle_tone1.39070665
37MP0003136_yellow_coat_color1.37568555
38MP0008995_early_reproductive_senescence1.33488160
39MP0000681_abnormal_thyroid_gland1.29167218
40MP0002132_abnormal_respiratory_system1.26521121
41MP0005187_abnormal_penis_morphology1.26367634
42MP0005645_abnormal_hypothalamus_physiol1.25449481
43MP0003786_premature_aging1.23208598
44MP0009333_abnormal_splenocyte_physiolog1.20578370
45MP0002272_abnormal_nervous_system1.19818889
46MP0004215_abnormal_myocardial_fiber1.19215035
47MP0001664_abnormal_digestion1.16907396
48MP0002638_abnormal_pupillary_reflex1.14619072
49MP0000747_muscle_weakness1.12159622
50MP0005397_hematopoietic_system_phenotyp1.10496665
51MP0001545_abnormal_hematopoietic_system1.10496665
52MP0002249_abnormal_larynx_morphology1.06447551
53MP0005377_hearing/vestibular/ear_phenot1.05188064
54MP0003878_abnormal_ear_physiology1.05188064
55MP0001873_stomach_inflammation1.04816399
56MP0005266_abnormal_metabolism1.02362170
57MP0002938_white_spotting1.02255932
58MP0002168_other_aberrant_phenotype1.01723872
59MP0001346_abnormal_lacrimal_gland0.99787615
60MP0001440_abnormal_grooming_behavior0.99786026
61MP0005395_other_phenotype0.99721330
62MP0002282_abnormal_trachea_morphology0.99508516
63MP0003698_abnormal_male_reproductive0.99350414
64MP0009765_abnormal_xenobiotic_induced0.99055254
65MP0009745_abnormal_behavioral_response0.98300251
66MP0008872_abnormal_physiological_respon0.98198423
67MP0002102_abnormal_ear_morphology0.95666371
68MP0003724_increased_susceptibility_to0.94566636
69MP0006276_abnormal_autonomic_nervous0.94436024
70MP0008058_abnormal_DNA_repair0.94401189
71MP0000230_abnormal_systemic_arterial0.92501614
72MP0009764_decreased_sensitivity_to0.90210854
73MP0001929_abnormal_gametogenesis0.87896416
74MP0004147_increased_porphyrin_level0.87343266
75MP0009053_abnormal_anal_canal0.86891556
76MP0001145_abnormal_male_reproductive0.86576673
77MP0003638_abnormal_response/metabolism_0.86247951
78MP0000653_abnormal_sex_gland0.85679237
79MP0003937_abnormal_limbs/digits/tail_de0.84925453
80MP0001486_abnormal_startle_reflex0.84456981
81MP0002210_abnormal_sex_determination0.80927524
82MP0003880_abnormal_central_pattern0.78652108
83MP0003631_nervous_system_phenotype0.77711019
84MP0002928_abnormal_bile_duct0.76906502
85MP0010329_abnormal_lipoprotein_level0.76636257
86MP0003119_abnormal_digestive_system0.76290838
87MP0001984_abnormal_olfaction0.76129812
88MP0004782_abnormal_surfactant_physiolog0.75087619
89MP0006292_abnormal_olfactory_placode0.73926883
90MP0004145_abnormal_muscle_electrophysio0.70576556
91MP0005464_abnormal_platelet_physiology0.69405250
92MP0004957_abnormal_blastocyst_morpholog0.68932953
93MP0005310_abnormal_salivary_gland0.68714437
94MP0003283_abnormal_digestive_organ0.68218725
95MP0004019_abnormal_vitamin_homeostasis0.67634941
96MP0005253_abnormal_eye_physiology0.65850013
97MP0003121_genomic_imprinting0.65077833
98MP0002971_abnormal_brown_adipose0.64843853
99MP0005647_abnormal_sex_gland0.64410062
100MP0004133_heterotaxia0.64112311

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)6.64557556
2Abnormal respiratory motile cilium physiology (HP:0012261)6.01179474
3Abnormal respiratory motile cilium morphology (HP:0005938)5.52530655
4Abnormal respiratory epithelium morphology (HP:0012253)5.52530655
5Dynein arm defect of respiratory motile cilia (HP:0012255)5.42490268
6Absent/shortened dynein arms (HP:0200106)5.42490268
7Thyroid-stimulating hormone excess (HP:0002925)4.79707756
8Visual hallucinations (HP:0002367)4.63020673
9Broad alveolar ridges (HP:0000187)4.59613733
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.26259856
11Congenital stationary night blindness (HP:0007642)4.21195587
12Rhinitis (HP:0012384)3.92899556
13Attenuation of retinal blood vessels (HP:0007843)3.83654913
14Distal arthrogryposis (HP:0005684)3.77248693
15Abnormality of the distal phalanges of the toes (HP:0010182)3.69452233
16Mesangial abnormality (HP:0001966)3.68259026
17Pancreatic cysts (HP:0001737)3.40003913
18Molar tooth sign on MRI (HP:0002419)3.30357827
19Abnormality of midbrain morphology (HP:0002418)3.30357827
20Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.26492082
21Pancreatic fibrosis (HP:0100732)3.26157249
22Peripheral hypomyelination (HP:0007182)3.24332133
23Axonal loss (HP:0003447)3.21494839
24Nephronophthisis (HP:0000090)3.19649644
25Sclerocornea (HP:0000647)3.10462081
26Dialeptic seizures (HP:0011146)3.08769749
27Cutaneous melanoma (HP:0012056)3.07755759
28True hermaphroditism (HP:0010459)3.03403889
29Anencephaly (HP:0002323)3.03382698
30Focal seizures (HP:0007359)2.95398422
31Chronic bronchitis (HP:0004469)2.94590679
32Medial flaring of the eyebrow (HP:0010747)2.88474611
33Adactyly (HP:0009776)2.88464775
34Volvulus (HP:0002580)2.85370963
35Ankle contracture (HP:0006466)2.84790446
36Cystic liver disease (HP:0006706)2.83582760
37Occipital encephalocele (HP:0002085)2.82617637
38Premature loss of primary teeth (HP:0006323)2.81463847
39Bronchiectasis (HP:0002110)2.79364014
40Nasal polyposis (HP:0100582)2.75620868
41Progressive inability to walk (HP:0002505)2.75273273
42Thickened helices (HP:0000391)2.74370362
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73619543
44Aplasia/Hypoplasia of the sternum (HP:0006714)2.73003334
45Chronic otitis media (HP:0000389)2.66090799
46Amyotrophic lateral sclerosis (HP:0007354)2.63161338
47Absent thumb (HP:0009777)2.60501603
48Chronic hepatic failure (HP:0100626)2.59268199
49Large for gestational age (HP:0001520)2.57596543
50Aplasia/Hypoplasia of the hallux (HP:0008362)2.54070160
51Abnormality of the renal medulla (HP:0100957)2.53694925
52Clumsiness (HP:0002312)2.51014362
53Chronic sinusitis (HP:0011109)2.50529328
54Chromsome breakage (HP:0040012)2.44323802
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.39865421
56Asplenia (HP:0001746)2.38076470
57Supernumerary spleens (HP:0009799)2.34065477
58Frequent falls (HP:0002359)2.33669448
59Acute necrotizing encephalopathy (HP:0006965)2.28443651
60Facial diplegia (HP:0001349)2.26627062
61Abnormality of the nasal mucosa (HP:0000433)2.26085995
62Status epilepticus (HP:0002133)2.23369044
63Congenital hepatic fibrosis (HP:0002612)2.22274950
64Duplicated collecting system (HP:0000081)2.19144393
65Bile duct proliferation (HP:0001408)2.15240903
66Abnormal biliary tract physiology (HP:0012439)2.15240903
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14385329
68Aplasia/Hypoplasia of the spleen (HP:0010451)2.12972232
69Abnormality of the renal cortex (HP:0011035)2.12891855
70Tubular atrophy (HP:0000092)2.11862798
71Abnormality of macular pigmentation (HP:0008002)2.08656281
72Glossoptosis (HP:0000162)2.08262831
73Nonprogressive disorder (HP:0003680)2.08250064
74Pancreatic islet-cell hyperplasia (HP:0004510)2.07388229
75Abnormality of the renal collecting system (HP:0004742)2.06506943
76Abnormality of the alveolar ridges (HP:0006477)2.06428896
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05881548
78Male pseudohermaphroditism (HP:0000037)2.04811458
79Gaze-evoked nystagmus (HP:0000640)2.04259090
80Cerebellar dysplasia (HP:0007033)2.02416743
81Furrowed tongue (HP:0000221)2.00870118
82Central scotoma (HP:0000603)1.98987305
83Abnormal mitochondria in muscle tissue (HP:0008316)1.98622405
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.97597002
85Progressive macrocephaly (HP:0004481)1.95642357
86Oligodontia (HP:0000677)1.94715183
87Decreased subcutaneous fat (HP:0001002)1.89437456
88Increased CSF lactate (HP:0002490)1.87895484
89Increased cerebral lipofuscin (HP:0011813)1.84479828
90Infertility (HP:0000789)1.84083449
91Abolished electroretinogram (ERG) (HP:0000550)1.83878686
92Squamous cell carcinoma (HP:0002860)1.82698873
93Congenital ichthyosiform erythroderma (HP:0007431)1.80475606
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.79899256
95Abnormality of the ileum (HP:0001549)1.79050429
96Congenital primary aphakia (HP:0007707)1.76871613
97Sparse scalp hair (HP:0002209)1.76767355
98Abnormal drinking behavior (HP:0030082)1.76093859
99Polydipsia (HP:0001959)1.76093859
100Postaxial foot polydactyly (HP:0001830)1.73547440

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.00498686
2ACVR1B5.97065093
3FRK5.24171176
4ADRBK23.88927034
5TLK13.71724465
6GRK13.00242049
7TEC2.92659274
8NUAK12.73670360
9BMPR1B2.56734231
10MAPKAPK32.42850518
11EEF2K2.32582549
12CCNB12.03637924
13MAP3K131.92331855
14TGFBR11.58097305
15MAP2K21.56809961
16ERN11.56044260
17TNIK1.52689169
18CSNK1G21.51727270
19ZAK1.38743958
20ITK1.34442520
21PINK11.32387331
22PTK2B1.28423725
23TRPM71.27867269
24BRAF1.08998760
25NTRK31.06730382
26ADRBK11.03704541
27MUSK1.00494605
28PNCK0.99442985
29MAP3K90.97304625
30EIF2AK10.96098511
31IRAK10.92584755
32EIF2AK30.90457008
33ARAF0.87368364
34STK160.87192233
35CDK80.86610233
36MAP2K10.80792354
37STK390.79537237
38PIM10.73934130
39RPS6KB20.72199915
40FES0.70851292
41RAF10.70250198
42BTK0.69960842
43PIK3CG0.69815130
44MAPKAPK50.68468479
45PRKCG0.64761636
46TTK0.61227500
47MAPK150.60998911
48SYK0.56982406
49CDC70.54902750
50INSRR0.52196048
51MAPK110.51680294
52OXSR10.51115063
53RPS6KA50.50349083
54TXK0.49113433
55IRAK30.48403007
56ERBB30.46041158
57AURKA0.45617791
58CSNK1G30.44633765
59WNK30.43084720
60PRKAA20.42691218
61MAPK130.40471878
62ATR0.39614766
63DMPK0.37416009
64CLK10.36967853
65KSR20.36278991
66PHKG10.35804373
67PHKG20.35804373
68KDR0.35305367
69KIT0.34275624
70DYRK30.34274831
71MKNK20.34255772
72MOS0.34212072
73GRK60.32849624
74CSNK1A1L0.31860061
75CHEK20.30023395
76WNK40.29993137
77CSNK1D0.29789000
78IGF1R0.29600031
79CSNK1G10.28691582
80FER0.27643140
81CSF1R0.24231100
82PBK0.24225189
83NEK90.24138131
84STK30.23328435
85PRKCE0.22648840
86ATM0.22056525
87CAMK2A0.21128632
88PRKCB0.20861463
89WEE10.19054253
90DAPK20.18834924
91CHEK10.18228484
92PRKACG0.18172039
93PRKCA0.17677805
94STK38L0.15947495
95PLK10.15556593
96ABL10.14972106
97CDK10.14875273
98PRKACA0.14610508
99IKBKB0.13835810
100LYN0.13471646

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.25393298
2Homologous recombination_Homo sapiens_hsa034403.16304962
3Nucleotide excision repair_Homo sapiens_hsa034203.12625890
4RNA polymerase_Homo sapiens_hsa030202.76403611
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41318640
6Sulfur relay system_Homo sapiens_hsa041222.36852957
7ABC transporters_Homo sapiens_hsa020102.31085778
8Phototransduction_Homo sapiens_hsa047442.30454358
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.25874933
10One carbon pool by folate_Homo sapiens_hsa006702.24007082
11Mismatch repair_Homo sapiens_hsa034302.16185820
12Olfactory transduction_Homo sapiens_hsa047402.10671320
13Nitrogen metabolism_Homo sapiens_hsa009102.08459939
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07480511
15DNA replication_Homo sapiens_hsa030302.03221821
16Glycerolipid metabolism_Homo sapiens_hsa005611.99874002
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.85282465
18Fanconi anemia pathway_Homo sapiens_hsa034601.84748021
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.67527227
20Linoleic acid metabolism_Homo sapiens_hsa005911.62447174
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57461627
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55676062
23Purine metabolism_Homo sapiens_hsa002301.52450180
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.50729336
25Sulfur metabolism_Homo sapiens_hsa009201.50253549
26Morphine addiction_Homo sapiens_hsa050321.44742182
27Base excision repair_Homo sapiens_hsa034101.43159287
28RNA degradation_Homo sapiens_hsa030181.40643699
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36364134
30Pyrimidine metabolism_Homo sapiens_hsa002401.35827138
31Nicotine addiction_Homo sapiens_hsa050331.30453568
32Tryptophan metabolism_Homo sapiens_hsa003801.30410411
33Dorso-ventral axis formation_Homo sapiens_hsa043201.28183184
34Butanoate metabolism_Homo sapiens_hsa006501.26567128
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25064607
36Serotonergic synapse_Homo sapiens_hsa047261.22342504
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21636059
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19273670
39Huntingtons disease_Homo sapiens_hsa050161.16963611
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.16732588
41Basal transcription factors_Homo sapiens_hsa030221.14319599
42Selenocompound metabolism_Homo sapiens_hsa004501.13281498
43Ovarian steroidogenesis_Homo sapiens_hsa049131.11397331
44Parkinsons disease_Homo sapiens_hsa050121.05999712
45Oxidative phosphorylation_Homo sapiens_hsa001901.04674639
46Chemical carcinogenesis_Homo sapiens_hsa052041.03355364
47Glutathione metabolism_Homo sapiens_hsa004801.02698455
48Graft-versus-host disease_Homo sapiens_hsa053321.01492047
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00232686
50Asthma_Homo sapiens_hsa053100.96753920
51Ether lipid metabolism_Homo sapiens_hsa005650.90106244
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89925896
53Arachidonic acid metabolism_Homo sapiens_hsa005900.86778521
54Retinol metabolism_Homo sapiens_hsa008300.84978772
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84896344
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.80263860
57Systemic lupus erythematosus_Homo sapiens_hsa053220.79822627
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79458677
59Sphingolipid metabolism_Homo sapiens_hsa006000.79367842
60Calcium signaling pathway_Homo sapiens_hsa040200.76415827
61Circadian entrainment_Homo sapiens_hsa047130.75909622
62Platelet activation_Homo sapiens_hsa046110.73173686
63Glutamatergic synapse_Homo sapiens_hsa047240.72715472
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72641416
65Taste transduction_Homo sapiens_hsa047420.72566003
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.72518018
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.71800176
68Long-term depression_Homo sapiens_hsa047300.70885572
69Type I diabetes mellitus_Homo sapiens_hsa049400.70773773
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70269333
71Allograft rejection_Homo sapiens_hsa053300.70076183
72Salivary secretion_Homo sapiens_hsa049700.68972418
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68078368
74Autoimmune thyroid disease_Homo sapiens_hsa053200.66479727
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62185471
76Metabolic pathways_Homo sapiens_hsa011000.58667392
77Alzheimers disease_Homo sapiens_hsa050100.57311042
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56252895
79Pancreatic secretion_Homo sapiens_hsa049720.50839746
80GABAergic synapse_Homo sapiens_hsa047270.50152845
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49128564
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48786394
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47332555
84Primary immunodeficiency_Homo sapiens_hsa053400.41526475
85beta-Alanine metabolism_Homo sapiens_hsa004100.39448896
86Oxytocin signaling pathway_Homo sapiens_hsa049210.37879611
87Rheumatoid arthritis_Homo sapiens_hsa053230.35730263
88Alcoholism_Homo sapiens_hsa050340.35480274
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34557936
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34216825
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.34155671
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32388215
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32347404
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30112649
95ECM-receptor interaction_Homo sapiens_hsa045120.29953965
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28719186
97Gastric acid secretion_Homo sapiens_hsa049710.28162101
98Arginine and proline metabolism_Homo sapiens_hsa003300.27771065
99Mineral absorption_Homo sapiens_hsa049780.27291951
100Starch and sucrose metabolism_Homo sapiens_hsa005000.26828654

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