ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	9.67876528
2	positive regulation of action potential (GO:0045760)	7.80589987
3	plasma membrane fusion (GO:0045026)	7.45096245
4	sperm motility (GO:0030317)	7.24469570
5	acrosome reaction (GO:0007340)	7.02788863
6	regulation of acrosome reaction (GO:0060046)	6.71720827
7	multicellular organism reproduction (GO:0032504)	6.19642704
8	motile cilium assembly (GO:0044458)	5.77298051
9	sperm-egg recognition (GO:0035036)	5.70539758
10	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	5.61312231
11	protein polyglutamylation (GO:0018095)	5.30285324
12	binding of sperm to zona pellucida (GO:0007339)	5.24453908
13	spermatid development (GO:0007286)	5.18338425
14	behavioral response to nicotine (GO:0035095)	5.15868266
15	cell-cell recognition (GO:0009988)	5.11980045
16	primary amino compound metabolic process (GO:1901160)	5.05423780
17	protein targeting to Golgi (GO:0000042)	4.97799845
18	reproduction (GO:0000003)	4.97654179
19	establishment of protein localization to Golgi (GO:0072600)	4.93118943
20	piRNA metabolic process (GO:0034587)	4.91156147
21	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.90961201
22	serotonin metabolic process (GO:0042428)	4.85951023
23	regulation of action potential (GO:0098900)	4.76380221
24	response to pheromone (GO:0019236)	4.64035926
25	DNA methylation involved in gamete generation (GO:0043046)	4.51632976
26	axonemal dynein complex assembly (GO:0070286)	4.51338656
27	cilium or flagellum-dependent cell motility (GO:0001539)	4.50776510
28	neuronal action potential (GO:0019228)	4.45721950
29	glomerular visceral epithelial cell development (GO:0072015)	4.42784586
30	epithelial cilium movement (GO:0003351)	4.32482561
31	fucose catabolic process (GO:0019317)	4.26441122
32	L-fucose metabolic process (GO:0042354)	4.26441122
33	L-fucose catabolic process (GO:0042355)	4.26441122
34	positive regulation of sodium ion transmembrane transport (GO:1902307)	4.18423016
35	calcium ion-dependent exocytosis (GO:0017156)	4.17962009
36	cellular ketone body metabolic process (GO:0046950)	4.06458650
37	regulation of cell communication by electrical coupling (GO:0010649)	4.01123687
38	single fertilization (GO:0007338)	4.00133248
39	seminiferous tubule development (GO:0072520)	3.97293151
40	glomerular epithelial cell development (GO:0072310)	3.95652719
41	regulation of protein targeting to membrane (GO:0090313)	3.88868181
42	protein localization to Golgi apparatus (GO:0034067)	3.85490320
43	male meiosis (GO:0007140)	3.83528798
44	spermatogenesis (GO:0007283)	3.81871611
45	male gamete generation (GO:0048232)	3.81280946
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.78769069
47	sperm capacitation (GO:0048240)	3.72570357
48	negative regulation of sodium ion transport (GO:0010766)	3.64722201
49	indole-containing compound metabolic process (GO:0042430)	3.62081065
50	protein K48-linked deubiquitination (GO:0071108)	3.60776593
51	ketone body metabolic process (GO:1902224)	3.55485710
52	growth hormone secretion (GO:0030252)	3.51548660
53	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.50543054
54	gamete generation (GO:0007276)	3.50210702
55	indole-containing compound catabolic process (GO:0042436)	3.44436814
56	indolalkylamine catabolic process (GO:0046218)	3.44436814
57	tryptophan catabolic process (GO:0006569)	3.44436814
58	centriole replication (GO:0007099)	3.42065775
59	cilium movement (GO:0003341)	3.37068659
60	microtubule severing (GO:0051013)	3.36748840
61	positive regulation of protein targeting to membrane (GO:0090314)	3.35908177
62	microtubule depolymerization (GO:0007019)	3.33853384
63	regulation of Rab GTPase activity (GO:0032313)	3.29015914
64	positive regulation of Rab GTPase activity (GO:0032851)	3.29015914
65	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.26135379
66	regulation of cilium movement (GO:0003352)	3.25629457
67	fertilization (GO:0009566)	3.25394566
68	intra-Golgi vesicle-mediated transport (GO:0006891)	3.24178087
69	microtubule polymerization or depolymerization (GO:0031109)	3.19880499
70	spermatid nucleus differentiation (GO:0007289)	3.18771930
71	NAD biosynthetic process (GO:0009435)	3.13088139
72	DNA packaging (GO:0006323)	3.10260990
73	coenzyme catabolic process (GO:0009109)	3.09110848
74	centriole assembly (GO:0098534)	3.05189463
75	head development (GO:0060322)	3.03590380
76	phosphatidylethanolamine metabolic process (GO:0046337)	3.03361568
77	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.98659070
78	alanine transport (GO:0032328)	2.98528340
79	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.97485872
80	tryptophan metabolic process (GO:0006568)	2.95034254
81	spinal cord motor neuron differentiation (GO:0021522)	2.91635748
82	action potential (GO:0001508)	2.87564801
83	regulation of meiosis I (GO:0060631)	2.86913465
84	musculoskeletal movement (GO:0050881)	2.85100776
85	multicellular organismal movement (GO:0050879)	2.85100776
86	chromosome condensation (GO:0030261)	2.83929979
87	intestinal cholesterol absorption (GO:0030299)	2.83204272
88	membrane depolarization during action potential (GO:0086010)	2.82926624
89	male meiosis I (GO:0007141)	2.81248195
90	regulation of centriole replication (GO:0046599)	2.80951193
91	germ cell development (GO:0007281)	2.79925095
92	regulation of microtubule-based movement (GO:0060632)	2.79303550
93	oxidative demethylation (GO:0070989)	2.77841712
94	organic cation transport (GO:0015695)	2.77799577
95	relaxation of smooth muscle (GO:0044557)	2.76843444
96	negative regulation of inclusion body assembly (GO:0090084)	2.76624291
97	multicellular organismal reproductive process (GO:0048609)	2.76497889
98	single strand break repair (GO:0000012)	2.73273893
99	reflex (GO:0060004)	2.73153307
100	pattern specification involved in kidney development (GO:0061004)	2.71137534

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.21480027
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.49688177
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.39067079
4	VDR_22108803_ChIP-Seq_LS180_Human	3.11034978
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.09991749
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.91713340
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.61061518
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.43823403
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20905456
10	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.14540681
11	FUS_26573619_Chip-Seq_HEK293_Human	2.12153985
12	DROSHA_22980978_ChIP-Seq_HELA_Human	2.11594738
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.04684250
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.02326137
15	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92132799
16	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90549396
17	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.90549396
18	CBP_20019798_ChIP-Seq_JUKART_Human	1.81820864
19	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.81820864
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.79498565
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71005147
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.69062356
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.68500595
24	* P300_19829295_ChIP-Seq_ESCs_Human	1.60715607
25	ERA_21632823_ChIP-Seq_H3396_Human	1.60575964
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60524698
27	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.55214020
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53167030
29	AR_25329375_ChIP-Seq_VCAP_Human	1.49507805
30	AHR_22903824_ChIP-Seq_MCF-7_Human	1.48988440
31	RAC3_21632823_ChIP-Seq_H3396_Human	1.48366417
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.48243541
33	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.40462539
34	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.39976424
35	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37195393
36	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.36789903
37	AR_21572438_ChIP-Seq_LNCaP_Human	1.36479624
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35384509
39	STAT3_23295773_ChIP-Seq_U87_Human	1.35177990
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34745679
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34585302
42	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.32881937
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32781426
44	TBL1_22424771_ChIP-Seq_293T_Human	1.32442105
45	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.31491607
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28756709
47	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.27128058
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26697432
49	TCF4_23295773_ChIP-Seq_U87_Human	1.26659198
50	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.26561754
51	* EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.26411109
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22795893
53	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.22489625
54	* OCT4_20526341_ChIP-Seq_ESCs_Human	1.22027342
55	ETV1_20927104_ChIP-Seq_GIST48_Human	1.20933933
56	NFYB_21822215_ChIP-Seq_K562_Human	1.20660767
57	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.20367214
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.19181425
59	HOXB7_26014856_ChIP-Seq_BT474_Human	1.18827627
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.18562526
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17281162
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17095888
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16892974
64	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16550924
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16293053
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16064672
67	PHF8_20622853_ChIP-Seq_HELA_Human	1.15994270
68	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.15622629
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15263150
70	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.14913077
71	NFYA_21822215_ChIP-Seq_K562_Human	1.14252216
72	TP53_18474530_ChIP-ChIP_U2OS_Human	1.13428539
73	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.13119617
74	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.13021105
75	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.12720696
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12717227
77	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12386563
78	RBPJ_21746931_ChIP-Seq_IB4_Human	1.12233045
79	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.11270687
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10862933
81	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.09307480
82	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.09072118
83	NCOR_22424771_ChIP-Seq_293T_Human	1.08553339
84	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08012834
85	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06215677
86	KDM2B_26808549_Chip-Seq_REH_Human	1.05774509
87	MYC_19829295_ChIP-Seq_ESCs_Human	1.04495577
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02437507
89	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02017514
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01645353
91	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.00890102
92	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.00715762
93	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00426620
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.99812439
95	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99602948
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99567767
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.98698726
98	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.97663628
99	* CTCF_20526341_ChIP-Seq_ESCs_Human	0.97623705
100	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.97218986

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.62884140
2	MP0003787_abnormal_imprinting	3.47830592
3	MP0003698_abnormal_male_reproductive	3.06986140
4	MP0005377_hearing/vestibular/ear_phenot	3.03195629
5	MP0003878_abnormal_ear_physiology	3.03195629
6	MP0003879_abnormal_hair_cell	2.78786473
7	MP0008877_abnormal_DNA_methylation	2.71200373
8	MP0005670_abnormal_white_adipose	2.43244560
9	MP0001929_abnormal_gametogenesis	2.31757079
10	MP0005646_abnormal_pituitary_gland	2.11814990
11	MP0005551_abnormal_eye_electrophysiolog	2.03291967
12	MP0008961_abnormal_basal_metabolism	1.98537900
13	MP0001486_abnormal_startle_reflex	1.95923605
14	MP0003283_abnormal_digestive_organ	1.94693924
15	MP0002735_abnormal_chemical_nociception	1.88584099
16	MP0003195_calcinosis	1.88468138
17	MP0001501_abnormal_sleep_pattern	1.86161218
18	MP0010386_abnormal_urinary_bladder	1.85599587
19	MP0002064_seizures	1.79142688
20	MP0009745_abnormal_behavioral_response	1.74941084
21	MP0001968_abnormal_touch/_nociception	1.69603787
22	MP0000569_abnormal_digit_pigmentation	1.67881439
23	MP0004133_heterotaxia	1.66706229
24	MP0001485_abnormal_pinna_reflex	1.64026110
25	MP0001873_stomach_inflammation	1.63986658
26	MP0005448_abnormal_energy_balance	1.62598420
27	MP0003119_abnormal_digestive_system	1.58015950
28	MP0005379_endocrine/exocrine_gland_phen	1.56648188
29	MP0002736_abnormal_nociception_after	1.54013441
30	MP0002161_abnormal_fertility/fecundity	1.52521052
31	MP0002822_catalepsy	1.51828248
32	MP0002733_abnormal_thermal_nociception	1.50849827
33	MP0006276_abnormal_autonomic_nervous	1.49608373
34	MP0002272_abnormal_nervous_system	1.47341823
35	MP0002210_abnormal_sex_determination	1.44482967
36	MP0005360_urolithiasis	1.42322726
37	MP0003137_abnormal_impulse_conducting	1.37991823
38	MP0005423_abnormal_somatic_nervous	1.37793847
39	MP0005645_abnormal_hypothalamus_physiol	1.37563841
40	MP0009697_abnormal_copulation	1.36708205
41	MP0000230_abnormal_systemic_arterial	1.35441804
42	MP0003011_delayed_dark_adaptation	1.33794631
43	MP0003959_abnormal_lean_body	1.33415736
44	MP0003718_maternal_effect	1.32664281
45	MP0009046_muscle_twitch	1.32646038
46	MP0000631_abnormal_neuroendocrine_gland	1.32300750
47	MP0003646_muscle_fatigue	1.27151153
48	MP0008872_abnormal_physiological_respon	1.23399676
49	MP0002572_abnormal_emotion/affect_behav	1.19953234
50	MP0001963_abnormal_hearing_physiology	1.19540460
51	MP0003635_abnormal_synaptic_transmissio	1.19171010
52	MP0001664_abnormal_digestion	1.18567677
53	MP0001970_abnormal_pain_threshold	1.18553612
54	MP0002067_abnormal_sensory_capabilities	1.13375924
55	MP0001145_abnormal_male_reproductive	1.12534606
56	MP0004859_abnormal_synaptic_plasticity	1.10914932
57	MP0002229_neurodegeneration	1.08815191
58	MP0002102_abnormal_ear_morphology	1.08360881
59	MP0000653_abnormal_sex_gland	1.08069332
60	MP0005365_abnormal_bile_salt	1.07981205
61	MP0002734_abnormal_mechanical_nocicepti	1.05593888
62	MP0001765_abnormal_ion_homeostasis	1.01619399
63	MP0002163_abnormal_gland_morphology	1.01219517
64	MP0005395_other_phenotype	1.01152566
65	MP0001666_abnormal_nutrient_absorption	1.01111377
66	MP0004742_abnormal_vestibular_system	1.00050067
67	MP0000470_abnormal_stomach_morphology	0.99946842
68	MP0000026_abnormal_inner_ear	0.98439012
69	MP0005253_abnormal_eye_physiology	0.97669130
70	MP0002069_abnormal_eating/drinking_beha	0.96912958
71	MP0001440_abnormal_grooming_behavior	0.95404202
72	MP0002837_dystrophic_cardiac_calcinosis	0.95285727
73	MP0002168_other_aberrant_phenotype	0.93099825
74	MP0002138_abnormal_hepatobiliary_system	0.92576314
75	MP0002909_abnormal_adrenal_gland	0.92346270
76	MP0005167_abnormal_blood-brain_barrier	0.91731886
77	MP0008004_abnormal_stomach_pH	0.89684241
78	MP0005174_abnormal_tail_pigmentation	0.89282056
79	MP0002063_abnormal_learning/memory/cond	0.89248245
80	MP0000015_abnormal_ear_pigmentation	0.88977289
81	MP0004130_abnormal_muscle_cell	0.88637098
82	MP0003045_fibrosis	0.87238735
83	MP0002160_abnormal_reproductive_system	0.86016418
84	MP0002557_abnormal_social/conspecific_i	0.84969801
85	MP0005595_abnormal_vascular_smooth	0.84067323
86	MP0003315_abnormal_perineum_morphology	0.81733286
87	MP0004085_abnormal_heartbeat	0.81194725
88	MP0002095_abnormal_skin_pigmentation	0.81062289
89	MP0004142_abnormal_muscle_tone	0.80619391
90	MP0005085_abnormal_gallbladder_physiolo	0.80592069
91	MP0000465_gastrointestinal_hemorrhage	0.80236910
92	MP0002638_abnormal_pupillary_reflex	0.79870781
93	MP0005332_abnormal_amino_acid	0.79399294
94	MP0002693_abnormal_pancreas_physiology	0.79262007
95	MP0003183_abnormal_peptide_metabolism	0.77609900
96	MP0010329_abnormal_lipoprotein_level	0.77387312
97	MP0005266_abnormal_metabolism	0.77203187
98	MP0005535_abnormal_body_temperature	0.75626593
99	MP0002078_abnormal_glucose_homeostasis	0.75114813
100	MP0002928_abnormal_bile_duct	0.75112707

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	8.37990694
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	8.37990694
3	Chronic hepatic failure (HP:0100626)	5.57358336
4	Abnormal ciliary motility (HP:0012262)	4.98587702
5	Abnormal respiratory epithelium morphology (HP:0012253)	4.82866674
6	Abnormal respiratory motile cilium morphology (HP:0005938)	4.82866674
7	Severe visual impairment (HP:0001141)	4.71588124
8	Nephronophthisis (HP:0000090)	4.33260165
9	Pancreatic cysts (HP:0001737)	4.21063789
10	Tubulointerstitial nephritis (HP:0001970)	4.07415588
11	Abnormal respiratory motile cilium physiology (HP:0012261)	4.06814587
12	Pancreatic fibrosis (HP:0100732)	3.81129242
13	Abnormality of the renal medulla (HP:0100957)	3.58880194
14	True hermaphroditism (HP:0010459)	3.48852364
15	Cystic liver disease (HP:0006706)	3.36890589
16	Attenuation of retinal blood vessels (HP:0007843)	3.21965766
17	Abnormality of midbrain morphology (HP:0002418)	3.20874730
18	Molar tooth sign on MRI (HP:0002419)	3.20874730
19	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.01831057
20	Infertility (HP:0000789)	2.91395397
21	Clumsiness (HP:0002312)	2.87339924
22	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.85549266
23	Pigmentary retinal degeneration (HP:0001146)	2.83571356
24	Congenital stationary night blindness (HP:0007642)	2.81046287
25	Atonic seizures (HP:0010819)	2.79980009
26	Progressive cerebellar ataxia (HP:0002073)	2.78685387
27	Polydipsia (HP:0001959)	2.78081880
28	Abnormal drinking behavior (HP:0030082)	2.78081880
29	Occipital encephalocele (HP:0002085)	2.77966344
30	Congenital sensorineural hearing impairment (HP:0008527)	2.74492699
31	Tubulointerstitial abnormality (HP:0001969)	2.73013773
32	Hypoplasia of the uterus (HP:0000013)	2.71048364
33	Protruding tongue (HP:0010808)	2.70933748
34	Stage 5 chronic kidney disease (HP:0003774)	2.68831692
35	Abolished electroretinogram (ERG) (HP:0000550)	2.66857396
36	Truncal obesity (HP:0001956)	2.63103789
37	Renovascular hypertension (HP:0100817)	2.62082620
38	Anencephaly (HP:0002323)	2.61827706
39	Growth hormone deficiency (HP:0000824)	2.54165935
40	Tubular atrophy (HP:0000092)	2.53247111
41	Bony spicule pigmentary retinopathy (HP:0007737)	2.51752798
42	Azoospermia (HP:0000027)	2.50937367
43	Abnormality of the renal cortex (HP:0011035)	2.50426119
44	Hypoplastic ischia (HP:0003175)	2.50293381
45	Enlarged epiphyses (HP:0010580)	2.50176643
46	Male pseudohermaphroditism (HP:0000037)	2.49537262
47	Inability to walk (HP:0002540)	2.42924852
48	Partial agenesis of the corpus callosum (HP:0001338)	2.41303583
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.40734617
50	Increased cerebral lipofuscin (HP:0011813)	2.33131568
51	Sensory axonal neuropathy (HP:0003390)	2.32028762
52	Large for gestational age (HP:0001520)	2.30753451
53	Agitation (HP:0000713)	2.30244888
54	Furrowed tongue (HP:0000221)	2.27170105
55	Nasal polyposis (HP:0100582)	2.25696328
56	Congenital hepatic fibrosis (HP:0002612)	2.23383323
57	Chorioretinal atrophy (HP:0000533)	2.23319365
58	Abnormal spermatogenesis (HP:0008669)	2.22632466
59	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.19629326
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17655108
61	Abnormality of macular pigmentation (HP:0008002)	2.13916643
62	Decreased circulating renin level (HP:0003351)	2.12138645
63	Amelogenesis imperfecta (HP:0000705)	2.11372418
64	Sclerocornea (HP:0000647)	2.11122715
65	Pendular nystagmus (HP:0012043)	2.09092322
66	Abnormality of the ischium (HP:0003174)	2.08422599
67	Keratoconus (HP:0000563)	2.06132884
68	Increased corneal curvature (HP:0100692)	2.06132884
69	Fibular hypoplasia (HP:0003038)	2.02035894
70	Polyuria (HP:0000103)	2.00353783
71	Cerebellar dysplasia (HP:0007033)	1.99097134
72	Fair hair (HP:0002286)	1.93907673
73	Abnormality of the right ventricle (HP:0001707)	1.93701247
74	Aplasia/hypoplasia of the uterus (HP:0008684)	1.90846677
75	Intellectual disability, moderate (HP:0002342)	1.85717616
76	Dialeptic seizures (HP:0011146)	1.85628445
77	Abnormal pancreas size (HP:0012094)	1.85150877
78	Abnormal albumin level (HP:0012116)	1.84708221
79	Hypoalbuminemia (HP:0003073)	1.84708221
80	Abnormal urine output (HP:0012590)	1.84206593
81	Abnormality of dental color (HP:0011073)	1.81671967
82	Cone-rod dystrophy (HP:0000548)	1.79082065
83	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.78945027
84	Chronic otitis media (HP:0000389)	1.78322620
85	Fibular aplasia (HP:0002990)	1.78025360
86	Abnormal biliary tract physiology (HP:0012439)	1.75590154
87	Bile duct proliferation (HP:0001408)	1.75590154
88	Abnormality of renal excretion (HP:0011036)	1.74206323
89	Bilateral microphthalmos (HP:0007633)	1.72733222
90	Abnormality of the nasal mucosa (HP:0000433)	1.72521543
91	Focal seizures (HP:0007359)	1.72180227
92	Hyperkalemia (HP:0002153)	1.71469138
93	Portal hypertension (HP:0001409)	1.71288731
94	Abnormality of purine metabolism (HP:0004352)	1.70897874
95	Decreased central vision (HP:0007663)	1.70662976
96	Genetic anticipation (HP:0003743)	1.68763392
97	Tubulointerstitial fibrosis (HP:0005576)	1.66438332
98	Type II lissencephaly (HP:0007260)	1.65727442
99	Hypothermia (HP:0002045)	1.62198263
100	Abnormality of the hepatic vasculature (HP:0006707)	1.62057133

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK2	4.76982732
2	PLK4	4.58509095
3	PINK1	3.35452048
4	BMPR1B	2.94132786
5	INSRR	2.64384629
6	CAMKK2	2.60156404
7	FRK	2.54798213
8	ACVR1B	2.50465526
9	ZAK	2.34574728
10	TYRO3	2.17870750
11	MAP4K2	2.06987257
12	BRD4	1.98936540
13	STK38	1.92403887
14	MAP3K4	1.89974437
15	MST1R	1.78360019
16	NTRK3	1.62676820
17	TIE1	1.54857715
18	PIK3CG	1.53824014
19	CAMK1G	1.49131702
20	CDK19	1.47892135
21	MAP3K9	1.47596382
22	TLK1	1.43576912
23	MARK3	1.41194135
24	STK16	1.40614506
25	WNK3	1.38949675
26	PNCK	1.36482923
27	NUAK1	1.27070788
28	ADRBK2	1.26686858
29	TGFBR1	1.25019266
30	WNK1	1.23831369
31	GRK1	1.20886701
32	TEC	1.17651429
33	PLK2	1.17482338
34	BCKDK	1.13138446
35	ITK	1.12779299
36	CAMK1D	1.12063278
37	PRKG2	1.07470392
38	MARK1	1.03227071
39	DDR2	1.03043087
40	CASK	1.00329710
41	MAPKAPK3	0.97864338
42	NEK2	0.92329323
43	PRKD3	0.91858591
44	TNIK	0.89643675
45	TESK1	0.89446543
46	DAPK1	0.88089782
47	RPS6KA5	0.87425350
48	MAP2K1	0.86880236
49	DAPK2	0.85609511
50	DYRK2	0.84927402
51	ADRBK1	0.82692776
52	MYLK	0.82386887
53	STK38L	0.82244993
54	WNK4	0.81652357
55	PRKCQ	0.81628989
56	PASK	0.81535756
57	BRSK2	0.80838005
58	PRKCG	0.78547909
59	LIMK1	0.77424256
60	MAP2K7	0.76427627
61	MAPK13	0.72879305
62	PTK2B	0.72388601
63	SYK	0.72325757
64	SGK494	0.71592191
65	SGK223	0.71592191
66	TAOK3	0.70581322
67	MAPK15	0.69855677
68	BTK	0.66873535
69	PDK1	0.66064994
70	CAMK1	0.64239131
71	PKN1	0.62945256
72	PRKAA1	0.58827427
73	CAMKK1	0.58727359
74	PAK6	0.58165385
75	PRKAA2	0.54657005
76	MAP2K6	0.52105073
77	PRKG1	0.51596844
78	NTRK2	0.49798372
79	PDPK1	0.49445385
80	SGK2	0.47704896
81	PRKCZ	0.45641798
82	HIPK2	0.42276635
83	PRKCH	0.41424052
84	CDK7	0.38552746
85	ICK	0.38120430
86	CDK12	0.37613847
87	ROCK1	0.36056302
88	PHKG2	0.35422806
89	PHKG1	0.35422806
90	PRKCB	0.30219605
91	CAMK2A	0.29638716
92	PRKACA	0.27910483
93	CSNK1D	0.26695216
94	RPS6KA3	0.26658329
95	CDK3	0.26400103
96	CAMK2B	0.25777096
97	OXSR1	0.25260085
98	MAP3K6	0.23711087
99	VRK1	0.23470907
100	CSNK1G3	0.22984122

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	3.58029393
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.51176639
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.88346832
4	Nicotine addiction_Homo sapiens_hsa05033	2.58729781
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.58007755
6	Phototransduction_Homo sapiens_hsa04744	2.56604353
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.38442078
8	Butanoate metabolism_Homo sapiens_hsa00650	2.35988658
9	Taste transduction_Homo sapiens_hsa04742	2.28731162
10	Fat digestion and absorption_Homo sapiens_hsa04975	2.26151998
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.13754470
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.07485732
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00576513
14	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.99209647
15	Pancreatic secretion_Homo sapiens_hsa04972	1.95664113
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.95032075
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.77583483
18	ABC transporters_Homo sapiens_hsa02010	1.75951949
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.72018843
20	Sulfur metabolism_Homo sapiens_hsa00920	1.63523129
21	Morphine addiction_Homo sapiens_hsa05032	1.58474005
22	Circadian entrainment_Homo sapiens_hsa04713	1.53676554
23	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.48920838
24	Salivary secretion_Homo sapiens_hsa04970	1.38045693
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.36662636
26	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.34193184
27	Insulin secretion_Homo sapiens_hsa04911	1.31658694
28	Protein digestion and absorption_Homo sapiens_hsa04974	1.31012049
29	Glutamatergic synapse_Homo sapiens_hsa04724	1.30974436
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.30461919
31	Gastric acid secretion_Homo sapiens_hsa04971	1.30268227
32	Glycerolipid metabolism_Homo sapiens_hsa00561	1.28013457
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.27388096
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.27120039
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26463840
36	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.23321479
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.22133806
38	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.19943419
39	Sulfur relay system_Homo sapiens_hsa04122	1.02856673
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.00045097
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.99909610
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.99234603
43	Gap junction_Homo sapiens_hsa04540	0.96239211
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91047926
45	GABAergic synapse_Homo sapiens_hsa04727	0.90799314
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90134187
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.89902993
48	Fatty acid degradation_Homo sapiens_hsa00071	0.89819166
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.88806510
50	Retinol metabolism_Homo sapiens_hsa00830	0.84720635
51	Serotonergic synapse_Homo sapiens_hsa04726	0.82882606
52	Propanoate metabolism_Homo sapiens_hsa00640	0.81542801
53	Circadian rhythm_Homo sapiens_hsa04710	0.79740091
54	Purine metabolism_Homo sapiens_hsa00230	0.78063913
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78020079
56	Peroxisome_Homo sapiens_hsa04146	0.77624465
57	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.77573256
58	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.77572645
59	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.75268077
60	Type II diabetes mellitus_Homo sapiens_hsa04930	0.74535703
61	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.73948598
62	Caffeine metabolism_Homo sapiens_hsa00232	0.69112818
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.65556258
64	Renin secretion_Homo sapiens_hsa04924	0.63648253
65	Basal transcription factors_Homo sapiens_hsa03022	0.63196191
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.62938811
67	RNA polymerase_Homo sapiens_hsa03020	0.61734686
68	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.59354278
69	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59139667
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58238492
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.57771906
72	Cholinergic synapse_Homo sapiens_hsa04725	0.57476987
73	Graft-versus-host disease_Homo sapiens_hsa05332	0.56936541
74	Cocaine addiction_Homo sapiens_hsa05030	0.55347373
75	RNA transport_Homo sapiens_hsa03013	0.52947292
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52810411
77	Histidine metabolism_Homo sapiens_hsa00340	0.52153412
78	Long-term depression_Homo sapiens_hsa04730	0.51655214
79	Bile secretion_Homo sapiens_hsa04976	0.51297962
80	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.50095306
81	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48382856
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48135100
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47800336
84	PPAR signaling pathway_Homo sapiens_hsa03320	0.47638797
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44693332
86	Amphetamine addiction_Homo sapiens_hsa05031	0.43067930
87	Allograft rejection_Homo sapiens_hsa05330	0.40610400
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39238573
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37872267
90	Metabolic pathways_Homo sapiens_hsa01100	0.37802491
91	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.37204172
92	Primary immunodeficiency_Homo sapiens_hsa05340	0.36046743
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.35305964
94	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.34972626
95	RNA degradation_Homo sapiens_hsa03018	0.34057012
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.33831394
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.30395535
98	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.29468866
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.27209569
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26906759

GOLGA8DP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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