ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement (GO:0003351)	9.98483036
2	axonemal dynein complex assembly (GO:0070286)	9.77283073
3	cilium movement (GO:0003341)	8.72186371
4	acrosome reaction (GO:0007340)	8.70246372
5	fusion of sperm to egg plasma membrane (GO:0007342)	8.58785090
6	motile cilium assembly (GO:0044458)	8.37775769
7	cilium or flagellum-dependent cell motility (GO:0001539)	7.82283446
8	centriole replication (GO:0007099)	7.07677602
9	spermatid development (GO:0007286)	6.99140379
10	sperm capacitation (GO:0048240)	6.74479037
11	plasma membrane fusion (GO:0045026)	6.51538822
12	multicellular organism reproduction (GO:0032504)	6.50996878
13	microtubule depolymerization (GO:0007019)	6.40046064
14	sperm-egg recognition (GO:0035036)	6.35834194
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.28827634
16	protein targeting to Golgi (GO:0000042)	6.17041562
17	establishment of protein localization to Golgi (GO:0072600)	6.08798399
18	protein polyglutamylation (GO:0018095)	5.98100298
19	response to pheromone (GO:0019236)	5.96360822
20	centriole assembly (GO:0098534)	5.89700371
21	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.87072546
22	binding of sperm to zona pellucida (GO:0007339)	5.53277815
23	spermatogenesis (GO:0007283)	5.52270778
24	microtubule polymerization or depolymerization (GO:0031109)	5.50745949
25	male gamete generation (GO:0048232)	5.50371341
26	axoneme assembly (GO:0035082)	5.44278937
27	chromosome condensation (GO:0030261)	5.40910550
28	reproduction (GO:0000003)	5.35698195
29	cell-cell recognition (GO:0009988)	5.32158750
30	regulation of cilium movement (GO:0003352)	5.25801638
31	single strand break repair (GO:0000012)	5.24337698
32	single fertilization (GO:0007338)	5.20448052
33	DNA packaging (GO:0006323)	5.14076629
34	gamete generation (GO:0007276)	5.04596380
35	ventricular system development (GO:0021591)	4.94712779
36	calcium ion-dependent exocytosis (GO:0017156)	4.88991400
37	protein localization to Golgi apparatus (GO:0034067)	4.82806243
38	cellular ketone body metabolic process (GO:0046950)	4.82435267
39	rRNA methylation (GO:0031167)	4.77594128
40	piRNA metabolic process (GO:0034587)	4.70627809
41	phosphatidylethanolamine metabolic process (GO:0046337)	4.62623362
42	seminiferous tubule development (GO:0072520)	4.59799450
43	regulation of meiosis I (GO:0060631)	4.52714356
44	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.47924508
45	fertilization (GO:0009566)	4.43240742
46	spermatid nucleus differentiation (GO:0007289)	4.33032142
47	positive regulation of Rab GTPase activity (GO:0032851)	4.31802962
48	regulation of Rab GTPase activity (GO:0032313)	4.31802962
49	RNA destabilization (GO:0050779)	4.26708606
50	ketone body metabolic process (GO:1902224)	4.21747472
51	regulation of centriole replication (GO:0046599)	4.20920523
52	rRNA modification (GO:0000154)	4.20912056
53	glomerular visceral epithelial cell development (GO:0072015)	4.13690954
54	glycerol ether metabolic process (GO:0006662)	4.03038460
55	multicellular organismal reproductive process (GO:0048609)	3.99289884
56	cilium organization (GO:0044782)	3.96961124
57	DNA methylation involved in gamete generation (GO:0043046)	3.90733669
58	cilium assembly (GO:0042384)	3.86045420
59	glomerular epithelial cell development (GO:0072310)	3.85071207
60	germ cell development (GO:0007281)	3.84782464
61	ether metabolic process (GO:0018904)	3.70722761
62	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.64275632
63	cell wall macromolecule catabolic process (GO:0016998)	3.63078329
64	cell wall macromolecule metabolic process (GO:0044036)	3.56490776
65	microtubule severing (GO:0051013)	3.53060689
66	negative regulation of inclusion body assembly (GO:0090084)	3.50697597
67	male meiosis (GO:0007140)	3.46358219
68	left/right axis specification (GO:0070986)	3.43014645
69	regulation of microtubule-based movement (GO:0060632)	3.37882874
70	organic cation transport (GO:0015695)	3.37394300
71	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.36128317
72	regulation of transcription involved in cell fate commitment (GO:0060850)	3.28244796
73	cilium morphogenesis (GO:0060271)	3.24187869
74	opioid receptor signaling pathway (GO:0038003)	3.23223750
75	regulation of acrosome reaction (GO:0060046)	3.16344913
76	coenzyme catabolic process (GO:0009109)	3.13769142
77	cellular component assembly involved in morphogenesis (GO:0010927)	3.07244130
78	sexual reproduction (GO:0019953)	3.04896207
79	microtubule nucleation (GO:0007020)	2.93342541
80	male meiosis I (GO:0007141)	2.92610305
81	multicellular organismal movement (GO:0050879)	2.88846640
82	musculoskeletal movement (GO:0050881)	2.88846640
83	membrane protein intracellular domain proteolysis (GO:0031293)	2.88411741
84	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.88125037
85	nucleoside diphosphate phosphorylation (GO:0006165)	2.86568971
86	left/right pattern formation (GO:0060972)	2.86266095
87	chromatin silencing (GO:0006342)	2.84702875
88	nucleus organization (GO:0006997)	2.81616937
89	microtubule-based movement (GO:0007018)	2.81115574
90	L-fucose catabolic process (GO:0042355)	2.77198826
91	fucose catabolic process (GO:0019317)	2.77198826
92	L-fucose metabolic process (GO:0042354)	2.77198826
93	meiotic cell cycle (GO:0051321)	2.73574300
94	photoreceptor cell maintenance (GO:0045494)	2.73404562
95	microtubule bundle formation (GO:0001578)	2.63828222
96	detection of light stimulus involved in visual perception (GO:0050908)	2.51443086
97	detection of light stimulus involved in sensory perception (GO:0050962)	2.51443086
98	positive regulation of meiosis (GO:0045836)	2.47522350
99	membrane depolarization during action potential (GO:0086010)	2.47299949
100	sperm motility (GO:0030317)	10.3004015

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.98364085
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.56910771
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.27943284
4	VDR_22108803_ChIP-Seq_LS180_Human	2.71781652
5	FUS_26573619_Chip-Seq_HEK293_Human	2.51104839
6	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.51056475
7	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.51056475
8	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.44152944
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42356627
10	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.40977456
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.40977456
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.29062747
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.21792951
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16228580
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14147747
16	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.12931811
17	DROSHA_22980978_ChIP-Seq_HELA_Human	2.03388002
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.94228656
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.92419031
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79095458
21	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.71805712
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68057662
23	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.65940972
24	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.65794542
25	NANOG_20526341_ChIP-Seq_ESCs_Human	1.65241355
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.64636249
27	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.63092938
28	ERA_21632823_ChIP-Seq_H3396_Human	1.62088750
29	RAC3_21632823_ChIP-Seq_H3396_Human	1.61316763
30	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.60473437
31	P300_19829295_ChIP-Seq_ESCs_Human	1.59447155
32	MYC_19829295_ChIP-Seq_ESCs_Human	1.56088185
33	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.51064466
34	STAT3_23295773_ChIP-Seq_U87_Human	1.49471754
35	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.48800121
36	CEBPB_22108803_ChIP-Seq_LS180_Human	1.48658425
37	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.46743627
38	TAF2_19829295_ChIP-Seq_ESCs_Human	1.46695973
39	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.43939592
40	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.42019597
41	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.40466973
42	OCT4_20526341_ChIP-Seq_ESCs_Human	1.39502911
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39120277
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39120277
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37698104
46	STAT1_20625510_ChIP-Seq_HELA_Human	1.33816770
47	ERG_20517297_ChIP-Seq_VCAP_Human	1.33687971
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.33383710
49	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.32788395
50	AR_25329375_ChIP-Seq_VCAP_Human	1.32725105
51	BCL6_27268052_Chip-Seq_Bcells_Human	1.30902023
52	E2F1_20622854_ChIP-Seq_HELA_Human	1.30624100
53	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.30250636
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30083571
55	RBPJ_21746931_ChIP-Seq_IB4_Human	1.29826920
56	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.28355569
57	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.28332158
58	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27953325
59	TBL1_22424771_ChIP-Seq_293T_Human	1.26726369
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26037368
61	NFYB_21822215_ChIP-Seq_K562_Human	1.25215296
62	ETV1_20927104_ChIP-Seq_GIST48_Human	1.24810154
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24418444
64	CTCF_20526341_ChIP-Seq_ESCs_Human	1.24078846
65	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.23906278
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23823554
67	HOXB7_26014856_ChIP-Seq_BT474_Human	1.22825652
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.22112161
69	SMAD4_21799915_ChIP-Seq_A2780_Human	1.21971707
70	P53_21459846_ChIP-Seq_SAOS-2_Human	1.21301997
71	NCOR_22424771_ChIP-Seq_293T_Human	1.20782637
72	PHF8_20622853_ChIP-Seq_HELA_Human	1.20080322
73	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.20035956
74	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.19087951
75	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.18158893
76	IGF1R_20145208_ChIP-Seq_DFB_Human	1.17740652
77	TCF4_23295773_ChIP-Seq_U87_Human	1.16879612
78	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.16810676
79	AR_21572438_ChIP-Seq_LNCaP_Human	1.16736517
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.16449625
81	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.16385246
82	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.15837842
83	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.15419225
84	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.15323739
85	P300_27268052_Chip-Seq_Bcells_Human	1.14006838
86	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.12810455
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12020045
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12020045
89	RXR_22108803_ChIP-Seq_LS180_Human	1.12011894
90	TAF15_26573619_Chip-Seq_HEK293_Human	1.09108296
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.08975268
92	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08955935
93	NFYA_21822215_ChIP-Seq_K562_Human	1.08190459
94	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07976593
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07782044
96	CDX2_22108803_ChIP-Seq_LS180_Human	1.06683647
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06391526
98	GATA3_26560356_Chip-Seq_TH1_Human	1.06371617
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06210638
100	BCOR_27268052_Chip-Seq_Bcells_Human	1.05316913

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	9.10745230
2	MP0005377_hearing/vestibular/ear_phenot	5.05334398
3	MP0003878_abnormal_ear_physiology	5.05334398
4	MP0003698_abnormal_male_reproductive	3.87044022
5	MP0001929_abnormal_gametogenesis	3.31678374
6	MP0003879_abnormal_hair_cell	2.90711424
7	MP0000566_synostosis	2.40091597
8	MP0005670_abnormal_white_adipose	2.35608821
9	MP0005551_abnormal_eye_electrophysiolog	2.19497409
10	MP0003718_maternal_effect	1.98218133
11	MP0001968_abnormal_touch/_nociception	1.96599750
12	MP0001485_abnormal_pinna_reflex	1.93551176
13	MP0001984_abnormal_olfaction	1.92545503
14	MP0002161_abnormal_fertility/fecundity	1.91543133
15	MP0001486_abnormal_startle_reflex	1.88616450
16	MP0008995_early_reproductive_senescence	1.82020964
17	MP0001348_abnormal_lacrimal_gland	1.79833752
18	MP0002210_abnormal_sex_determination	1.74216969
19	MP0005360_urolithiasis	1.73370269
20	MP0001765_abnormal_ion_homeostasis	1.69285237
21	MP0002876_abnormal_thyroid_physiology	1.67395327
22	MP0003646_muscle_fatigue	1.62965155
23	MP0003806_abnormal_nucleotide_metabolis	1.58671968
24	MP0001145_abnormal_male_reproductive	1.47858366
25	MP0000678_abnormal_parathyroid_gland	1.47300748
26	MP0000653_abnormal_sex_gland	1.44114296
27	MP0002132_abnormal_respiratory_system	1.43024255
28	MP0004742_abnormal_vestibular_system	1.40459613
29	MP0008007_abnormal_cellular_replicative	1.33926589
30	MP0005253_abnormal_eye_physiology	1.32642731
31	MP0001963_abnormal_hearing_physiology	1.31041840
32	MP0002822_catalepsy	1.29740600
33	MP0002282_abnormal_trachea_morphology	1.23676198
34	MP0002138_abnormal_hepatobiliary_system	1.21828965
35	MP0000230_abnormal_systemic_arterial	1.13852415
36	MP0006072_abnormal_retinal_apoptosis	1.13187925
37	MP0009278_abnormal_bone_marrow	1.13179063
38	MP0005310_abnormal_salivary_gland	1.12833047
39	MP0000026_abnormal_inner_ear	1.12675078
40	MP0009046_muscle_twitch	1.12365331
41	MP0002229_neurodegeneration	1.12167914
42	MP0009745_abnormal_behavioral_response	1.08488562
43	MP0002249_abnormal_larynx_morphology	1.07892188
44	MP0001501_abnormal_sleep_pattern	1.06639392
45	MP0005408_hypopigmentation	1.05904068
46	MP0010386_abnormal_urinary_bladder	1.05900767
47	MP0002272_abnormal_nervous_system	1.02526932
48	MP0003136_yellow_coat_color	1.00505232
49	MP0008775_abnormal_heart_ventricle	0.94946458
50	MP0004085_abnormal_heartbeat	0.92423632
51	MP0000681_abnormal_thyroid_gland	0.91256304
52	MP0004043_abnormal_pH_regulation	0.90084665
53	MP0002160_abnormal_reproductive_system	0.89036890
54	MP0004019_abnormal_vitamin_homeostasis	0.88337883
55	MP0005332_abnormal_amino_acid	0.85769463
56	MP0001545_abnormal_hematopoietic_system	0.85242220
57	MP0005397_hematopoietic_system_phenotyp	0.85242220
58	MP0001835_abnormal_antigen_presentation	0.85078164
59	MP0006276_abnormal_autonomic_nervous	0.84879768
60	MP0001664_abnormal_digestion	0.84175921
61	MP0002234_abnormal_pharynx_morphology	0.82164147
62	MP0005645_abnormal_hypothalamus_physiol	0.81602408
63	MP0002735_abnormal_chemical_nociception	0.79383524
64	MP0001970_abnormal_pain_threshold	0.76812348
65	MP0005395_other_phenotype	0.76610232
66	MP0003011_delayed_dark_adaptation	0.75931731
67	MP0002572_abnormal_emotion/affect_behav	0.74202658
68	MP0000538_abnormal_urinary_bladder	0.73876957
69	MP0008004_abnormal_stomach_pH	0.71586570
70	MP0000579_abnormal_nail_morphology	0.71498305
71	MP0002733_abnormal_thermal_nociception	0.70678411
72	MP0002067_abnormal_sensory_capabilities	0.70654637
73	MP0005636_abnormal_mineral_homeostasis	0.69930095
74	MP0005535_abnormal_body_temperature	0.69118309
75	MP0009764_decreased_sensitivity_to	0.69075823
76	MP0003045_fibrosis	0.69067296
77	MP0010329_abnormal_lipoprotein_level	0.68954202
78	MP0002653_abnormal_ependyma_morphology	0.68945740
79	MP0008789_abnormal_olfactory_epithelium	0.68931527
80	MP0004084_abnormal_cardiac_muscle	0.68471099
81	MP0005451_abnormal_body_composition	0.66536014
82	MP0003315_abnormal_perineum_morphology	0.64520102
83	MP0003786_premature_aging	0.64432135
84	MP0005167_abnormal_blood-brain_barrier	0.62844087
85	MP0005394_taste/olfaction_phenotype	0.62150112
86	MP0005499_abnormal_olfactory_system	0.62150112
87	MP0005646_abnormal_pituitary_gland	0.61688777
88	MP0002928_abnormal_bile_duct	0.60830190
89	MP0009765_abnormal_xenobiotic_induced	0.60742085
90	MP0005389_reproductive_system_phenotype	0.59325466
91	MP0005266_abnormal_metabolism	0.58814285
92	MP0005595_abnormal_vascular_smooth	0.57812143
93	MP0001905_abnormal_dopamine_level	0.56759917
94	MP0002736_abnormal_nociception_after	0.56754956
95	MP0008872_abnormal_physiological_respon	0.56734146
96	MP0005423_abnormal_somatic_nervous	0.56571991
97	MP0000465_gastrointestinal_hemorrhage	0.55352542
98	MP0008058_abnormal_DNA_repair	0.54858586
99	MP0002136_abnormal_kidney_physiology	0.54200318
100	MP0005464_abnormal_platelet_physiology	0.53962323

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	9.27113638
2	Absent/shortened dynein arms (HP:0200106)	9.27113638
3	Abnormal ciliary motility (HP:0012262)	8.08148909
4	Abnormal respiratory motile cilium physiology (HP:0012261)	7.26626648
5	Abnormal respiratory epithelium morphology (HP:0012253)	7.01511428
6	Abnormal respiratory motile cilium morphology (HP:0005938)	7.01511428
7	Chronic hepatic failure (HP:0100626)	5.80806869
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.22429321
9	Tubulointerstitial nephritis (HP:0001970)	4.52657708
10	Nasal polyposis (HP:0100582)	4.36324173
11	Severe visual impairment (HP:0001141)	4.24820047
12	Rhinitis (HP:0012384)	4.02376066
13	Pancreatic fibrosis (HP:0100732)	3.94920295
14	Pancreatic cysts (HP:0001737)	3.87672177
15	Nephronophthisis (HP:0000090)	3.86204453
16	Attenuation of retinal blood vessels (HP:0007843)	3.71369600
17	True hermaphroditism (HP:0010459)	3.70637584
18	Infertility (HP:0000789)	3.69720915
19	Cystic liver disease (HP:0006706)	3.68010586
20	Occipital encephalocele (HP:0002085)	3.65544319
21	Abnormality of the nasal mucosa (HP:0000433)	3.50891446
22	Bony spicule pigmentary retinopathy (HP:0007737)	3.41694987
23	Abnormality of macular pigmentation (HP:0008002)	3.25194337
24	Abnormal drinking behavior (HP:0030082)	3.22291946
25	Polydipsia (HP:0001959)	3.22291946
26	Bronchiectasis (HP:0002110)	3.21832707
27	Male infertility (HP:0003251)	3.10636115
28	Abnormality of the renal medulla (HP:0100957)	3.09214646
29	Abnormality of midbrain morphology (HP:0002418)	3.02738984
30	Molar tooth sign on MRI (HP:0002419)	3.02738984
31	Cone-rod dystrophy (HP:0000548)	2.98146455
32	Asymmetric septal hypertrophy (HP:0001670)	2.83202530
33	Tubular atrophy (HP:0000092)	2.78152959
34	Chronic bronchitis (HP:0004469)	2.71878773
35	Chronic sinusitis (HP:0011109)	2.62218066
36	Bell-shaped thorax (HP:0001591)	2.59548253
37	Hyperkalemia (HP:0002153)	2.58260591
38	Tubulointerstitial abnormality (HP:0001969)	2.55208353
39	Anencephaly (HP:0002323)	2.47392587
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.43960285
41	Abnormality of dental color (HP:0011073)	2.41940031
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.40471141
43	Polyuria (HP:0000103)	2.37201890
44	Congenital hepatic fibrosis (HP:0002612)	2.36821955
45	Medial flaring of the eyebrow (HP:0010747)	2.33522496
46	Sclerocornea (HP:0000647)	2.30634120
47	Stage 5 chronic kidney disease (HP:0003774)	2.30083293
48	Abnormal urine output (HP:0012590)	2.28312614
49	Congenital stationary night blindness (HP:0007642)	2.21722140
50	Male pseudohermaphroditism (HP:0000037)	2.20145390
51	Bile duct proliferation (HP:0001408)	2.20063600
52	Abnormal biliary tract physiology (HP:0012439)	2.20063600
53	Atonic seizures (HP:0010819)	2.19234463
54	Hypoplasia of the thymus (HP:0000778)	2.17043641
55	Abdominal situs inversus (HP:0003363)	2.16935407
56	Abnormality of abdominal situs (HP:0011620)	2.16935407
57	Thyroid-stimulating hormone excess (HP:0002925)	2.13976786
58	Portal hypertension (HP:0001409)	2.12678707
59	Congenital sensorineural hearing impairment (HP:0008527)	2.11494366
60	Supernumerary spleens (HP:0009799)	2.10287061
61	Chronic otitis media (HP:0000389)	2.08391966
62	Intellectual disability, moderate (HP:0002342)	2.08300135
63	Abolished electroretinogram (ERG) (HP:0000550)	2.04876002
64	Amelogenesis imperfecta (HP:0000705)	2.04057257
65	Progressive cerebellar ataxia (HP:0002073)	2.03566492
66	Recurrent sinusitis (HP:0011108)	2.03249048
67	Enlarged epiphyses (HP:0010580)	2.02458048
68	Abnormality of the renal cortex (HP:0011035)	2.00013187
69	Abnormality of the hepatic vasculature (HP:0006707)	1.95318895
70	Cerebellar dysplasia (HP:0007033)	1.95146170
71	Abnormality of dentin (HP:0010299)	1.93376717
72	Abnormality of renal excretion (HP:0011036)	1.90919039
73	Hypophosphatemic rickets (HP:0004912)	1.87461141
74	Facial shape deformation (HP:0011334)	1.83482016
75	Potter facies (HP:0002009)	1.83482016
76	Postaxial foot polydactyly (HP:0001830)	1.80504895
77	Hypergonadotropic hypogonadism (HP:0000815)	1.79296203
78	Hypoplasia of the uterus (HP:0000013)	1.79099380
79	Pendular nystagmus (HP:0012043)	1.77810052
80	Decreased central vision (HP:0007663)	1.76731705
81	Congenital primary aphakia (HP:0007707)	1.76168089
82	Gait imbalance (HP:0002141)	1.75301383
83	Abnormal spermatogenesis (HP:0008669)	1.73898491
84	Hypoplastic ischia (HP:0003175)	1.72641907
85	Poor coordination (HP:0002370)	1.72057707
86	Abnormality of the aortic arch (HP:0012303)	1.71107442
87	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.69890638
88	Oculomotor apraxia (HP:0000657)	1.68821720
89	Type II lissencephaly (HP:0007260)	1.65319670
90	Short nail (HP:0001799)	1.64936998
91	Furrowed tongue (HP:0000221)	1.63501426
92	Azoospermia (HP:0000027)	1.59440054
93	Decreased circulating renin level (HP:0003351)	1.59298115
94	Renal Fanconi syndrome (HP:0001994)	1.58782281
95	Generalized aminoaciduria (HP:0002909)	1.58698965
96	Keratoconus (HP:0000563)	1.58220822
97	Increased corneal curvature (HP:0100692)	1.58220822
98	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.57710342
99	Macular degeneration (HP:0000608)	1.57632151
100	Retinitis pigmentosa (HP:0000510)	1.56637513

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	6.31978739
2	INSRR	4.56592211
3	MAP4K2	3.81883109
4	PLK2	3.42927693
5	WNK4	3.26699604
6	BRD4	3.05061182
7	ACVR1B	2.69775653
8	PINK1	2.67268898
9	FRK	2.43281649
10	BMPR1B	2.42342146
11	PIK3CG	2.36874711
12	MST1R	2.27645742
13	DDR2	2.14155291
14	ADRBK2	2.09211416
15	PTK2B	2.07981925
16	ZAK	1.97145370
17	TLK1	1.87812247
18	STK38L	1.87254935
19	MAPK15	1.87252788
20	PNCK	1.78206171
21	KIT	1.70703541
22	CCNB1	1.67731634
23	FLT3	1.66983541
24	WNK1	1.59345249
25	STK38	1.49591492
26	MUSK	1.30197971
27	TEC	1.25453947
28	STK16	1.18427789
29	CDK12	1.15237327
30	TGFBR1	1.11352541
31	ITK	1.10011486
32	MAP2K6	1.07764132
33	TESK1	1.06654985
34	TIE1	1.05662844
35	TYRO3	1.05605308
36	MAPKAPK3	1.04747702
37	CAMK1G	1.00740927
38	STK39	0.98590395
39	PDK1	0.97216320
40	SYK	0.89939296
41	SIK2	0.88436582
42	CSF1R	0.81895307
43	TNIK	0.78155376
44	PDPK1	0.73252092
45	GRK1	0.72153744
46	JAK3	0.70785896
47	ADRBK1	0.69394687
48	MARK3	0.65825583
49	TAOK3	0.63618895
50	RIPK4	0.63468585
51	BTK	0.63047211
52	NEK2	0.60140572
53	PRKG1	0.59093139
54	TRPM7	0.56931099
55	PRKCQ	0.56405714
56	BMPR2	0.56060377
57	LATS1	0.53857234
58	MAP2K1	0.52737491
59	FES	0.49670111
60	MET	0.49055143
61	CDK7	0.48660745
62	MAP3K4	0.47182917
63	PRKCE	0.47100719
64	NME1	0.46127892
65	MAP3K13	0.43437373
66	CAMK1	0.43189575
67	CDK3	0.41794069
68	PRKCG	0.41547440
69	RPS6KA5	0.40297232
70	PBK	0.39833180
71	PRKAA2	0.36751785
72	PRKG2	0.36059218
73	OXSR1	0.35711495
74	MAP2K2	0.33512882
75	SGK1	0.31772750
76	NEK6	0.31748189
77	DYRK1B	0.29902327
78	IKBKB	0.29377806
79	MAPK1	0.29187967
80	MAPK11	0.28947882
81	CSNK1A1	0.28398997
82	PRKCI	0.27039884
83	CDK2	0.26206263
84	RPS6KA2	0.26144209
85	GSK3B	0.24883966
86	KSR2	0.24868333
87	LYN	0.24763007
88	TNK2	0.24529101
89	MAP2K7	0.24145978
90	WNK3	0.22558013
91	PHKG1	0.21619540
92	PHKG2	0.21619540
93	NTRK3	0.21614323
94	PRKCB	0.21018855
95	CDK1	0.20702479
96	PRKCZ	0.20697332
97	RPS6KA1	0.20062060
98	ZAP70	0.19664895
99	IGF1R	0.19544558
100	MAP2K3	0.19492690

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.15174338
2	Olfactory transduction_Homo sapiens_hsa04740	4.07220614
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.73497707
4	Allograft rejection_Homo sapiens_hsa05330	3.29896178
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.12370111
6	Asthma_Homo sapiens_hsa05310	3.07701794
7	Graft-versus-host disease_Homo sapiens_hsa05332	3.03735545
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.95318792
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.56648703
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.29812076
11	Phototransduction_Homo sapiens_hsa04744	2.29117059
12	Butanoate metabolism_Homo sapiens_hsa00650	2.22705341
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.77355174
14	ABC transporters_Homo sapiens_hsa02010	1.61009384
15	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.59016580
16	Taste transduction_Homo sapiens_hsa04742	1.54881669
17	Salivary secretion_Homo sapiens_hsa04970	1.50077197
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.50044636
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.41226861
20	Viral myocarditis_Homo sapiens_hsa05416	1.27061818
21	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.25648325
22	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.23261136
23	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.20348812
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.19701912
25	Glycerolipid metabolism_Homo sapiens_hsa00561	1.16571757
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.15120273
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.14304844
28	RNA transport_Homo sapiens_hsa03013	1.10804245
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09465950
30	Morphine addiction_Homo sapiens_hsa05032	1.08870510
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07051887
32	Purine metabolism_Homo sapiens_hsa00230	1.06824520
33	Nicotine addiction_Homo sapiens_hsa05033	1.05801168
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.02902232
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00008070
36	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.98519173
37	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98104643
38	Basal transcription factors_Homo sapiens_hsa03022	0.89202409
39	Linoleic acid metabolism_Homo sapiens_hsa00591	0.88256937
40	Glutamatergic synapse_Homo sapiens_hsa04724	0.87881885
41	Type II diabetes mellitus_Homo sapiens_hsa04930	0.86866298
42	Fatty acid degradation_Homo sapiens_hsa00071	0.86564619
43	Circadian entrainment_Homo sapiens_hsa04713	0.86468567
44	Huntingtons disease_Homo sapiens_hsa05016	0.84587978
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83203231
46	Peroxisome_Homo sapiens_hsa04146	0.83037387
47	Protein digestion and absorption_Homo sapiens_hsa04974	0.82303667
48	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.82163540
49	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.78042490
50	Pancreatic secretion_Homo sapiens_hsa04972	0.74527872
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71238602
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70312292
53	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.69401730
54	Leishmaniasis_Homo sapiens_hsa05140	0.67403707
55	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.67258784
56	Influenza A_Homo sapiens_hsa05164	0.64794230
57	Serotonergic synapse_Homo sapiens_hsa04726	0.64585771
58	Phagosome_Homo sapiens_hsa04145	0.60062320
59	Retinol metabolism_Homo sapiens_hsa00830	0.58355563
60	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.57320327
61	Arginine biosynthesis_Homo sapiens_hsa00220	0.57218036
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56722547
63	Insulin secretion_Homo sapiens_hsa04911	0.56342752
64	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56332191
65	Rheumatoid arthritis_Homo sapiens_hsa05323	0.56269974
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55454175
67	RNA polymerase_Homo sapiens_hsa03020	0.54909812
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.54372331
69	Regulation of autophagy_Homo sapiens_hsa04140	0.54094100
70	Glutathione metabolism_Homo sapiens_hsa00480	0.52620059
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.51503077
72	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.48718521
73	GABAergic synapse_Homo sapiens_hsa04727	0.46815935
74	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46349719
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.45935966
76	Primary immunodeficiency_Homo sapiens_hsa05340	0.44914963
77	Caffeine metabolism_Homo sapiens_hsa00232	0.44768428
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43574365
79	mRNA surveillance pathway_Homo sapiens_hsa03015	0.43491016
80	Sulfur metabolism_Homo sapiens_hsa00920	0.42388057
81	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42122493
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41825840
83	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.41469170
84	PPAR signaling pathway_Homo sapiens_hsa03320	0.40937601
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.40564956
86	Oocyte meiosis_Homo sapiens_hsa04114	0.40038386
87	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39179589
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38775335
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37346138
90	Platelet activation_Homo sapiens_hsa04611	0.36581625
91	Metabolic pathways_Homo sapiens_hsa01100	0.35514017
92	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35178278
93	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.35095574
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34950147
95	Phenylalanine metabolism_Homo sapiens_hsa00360	0.34560237
96	Gastric acid secretion_Homo sapiens_hsa04971	0.33216856
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32998745
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.32944249
99	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.32557806
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31724795

GOLGA8EP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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