GOLGA8F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.37736562
2sperm capacitation (GO:0048240)9.10543598
3plasma membrane fusion (GO:0045026)8.69569180
4chromosome condensation (GO:0030261)8.22100809
5spermatid development (GO:0007286)8.16962717
6microtubule depolymerization (GO:0007019)8.04787742
7DNA packaging (GO:0006323)7.92542376
8multicellular organism reproduction (GO:0032504)7.91974663
9sperm-egg recognition (GO:0035036)7.80681778
10single strand break repair (GO:0000012)7.08576137
11reproduction (GO:0000003)7.01388129
12binding of sperm to zona pellucida (GO:0007339)6.99528719
13spermatid nucleus differentiation (GO:0007289)6.89794018
14calcium ion-dependent exocytosis (GO:0017156)6.76195496
15cell-cell recognition (GO:0009988)6.47997909
16microtubule polymerization or depolymerization (GO:0031109)6.46387442
17axonemal dynein complex assembly (GO:0070286)6.44390466
18cellular ketone body metabolic process (GO:0046950)6.34192406
19negative regulation of inclusion body assembly (GO:0090084)6.22593274
20phosphatidylethanolamine biosynthetic process (GO:0006646)6.03652580
21protein polyglutamylation (GO:0018095)6.02390485
22spermatogenesis (GO:0007283)5.95416293
23male gamete generation (GO:0048232)5.93300696
24rRNA methylation (GO:0031167)5.88883211
25microtubule severing (GO:0051013)5.85494798
26protein targeting to Golgi (GO:0000042)5.81241470
27centriole replication (GO:0007099)5.76991228
28establishment of protein localization to Golgi (GO:0072600)5.71896280
29phosphatidylethanolamine metabolic process (GO:0046337)5.64870458
30ketone body metabolic process (GO:1902224)5.58009856
31sexual reproduction (GO:0019953)5.51547524
32gamete generation (GO:0007276)5.42251984
33retrograde transport, vesicle recycling within Golgi (GO:0000301)5.34692137
34positive regulation of Rab GTPase activity (GO:0032851)5.25211481
35regulation of Rab GTPase activity (GO:0032313)5.25211481
36cilium or flagellum-dependent cell motility (GO:0001539)5.20997458
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.19340084
38single fertilization (GO:0007338)5.17676905
39regulation of cilium movement (GO:0003352)5.17149890
40motile cilium assembly (GO:0044458)5.12089523
41centriole assembly (GO:0098534)4.96316199
42rRNA modification (GO:0000154)4.89496568
43epithelial cilium movement (GO:0003351)4.70865380
44regulation of transcription involved in cell fate commitment (GO:0060850)4.55150066
45germ cell development (GO:0007281)4.54256735
46coenzyme catabolic process (GO:0009109)4.40168662
47protein localization to Golgi apparatus (GO:0034067)4.35833048
48multicellular organismal reproductive process (GO:0048609)4.32694797
49cellular process involved in reproduction in multicellular organism (GO:0022412)4.30356776
50regulation of inclusion body assembly (GO:0090083)4.29751227
51cell wall macromolecule catabolic process (GO:0016998)4.23921342
52cilium movement (GO:0003341)4.21347955
53cell wall macromolecule metabolic process (GO:0044036)4.16958985
54organic cation transport (GO:0015695)4.16052250
55fertilization (GO:0009566)4.15175595
56RNA destabilization (GO:0050779)4.10172628
57negative regulation of Rho protein signal transduction (GO:0035024)3.95462295
58regulation of microtubule-based movement (GO:0060632)3.77820474
59chromatin silencing (GO:0006342)3.77280338
60regulation of centriole replication (GO:0046599)3.75119645
61peptidyl-threonine dephosphorylation (GO:0035970)3.69227136
62seminiferous tubule development (GO:0072520)3.64995551
63NAD biosynthetic process (GO:0009435)3.57281382
64nucleus organization (GO:0006997)3.47256554
65cellular response to pH (GO:0071467)3.41741725
66multicellular organismal movement (GO:0050879)3.40758286
67musculoskeletal movement (GO:0050881)3.40758286
68response to acidic pH (GO:0010447)3.39669216
69polyamine biosynthetic process (GO:0006596)3.38706609
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31776739
71regulation of somitogenesis (GO:0014807)3.28528531
72cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.23392995
73glycerol ether metabolic process (GO:0006662)3.22403739
74regulation of phosphoprotein phosphatase activity (GO:0043666)3.11839058
75cell recognition (GO:0008037)3.08850019
76regulation of female gonad development (GO:2000194)3.08524874
77histone H3-K9 demethylation (GO:0033169)3.02729185
78male meiosis (GO:0007140)3.01464573
79DNA methylation involved in gamete generation (GO:0043046)2.99394365
80piRNA metabolic process (GO:0034587)2.98730202
81ether metabolic process (GO:0018904)2.97281027
82multicellular organismal development (GO:0007275)2.95261479
83negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.91938407
84detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.91445502
85cerebral cortex neuron differentiation (GO:0021895)2.91390322
86protein depolymerization (GO:0051261)2.90654084
87membrane protein intracellular domain proteolysis (GO:0031293)2.84642700
88cell differentiation involved in metanephros development (GO:0072202)2.77868840
89cranial nerve morphogenesis (GO:0021602)2.76260230
90pyridine nucleotide biosynthetic process (GO:0019363)2.75667166
91nicotinamide nucleotide biosynthetic process (GO:0019359)2.75667166
92nucleosome disassembly (GO:0006337)2.72401334
93protein-DNA complex disassembly (GO:0032986)2.72401334
94mesenchymal cell differentiation involved in renal system development (GO:2001012)2.71630965
95mesenchymal cell differentiation involved in kidney development (GO:0072161)2.71630965
96regulation of interleukin-13 production (GO:0032656)2.71302013
97positive regulation of action potential (GO:0045760)2.67357906
98acrosome reaction (GO:0007340)11.9469296
99sperm motility (GO:0030317)11.4185296
100fusion of sperm to egg plasma membrane (GO:0007342)11.3818557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.56554338
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.15993673
3EZH2_22144423_ChIP-Seq_EOC_Human2.95803002
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70725698
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41489657
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.41203665
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41203665
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24997146
9CBP_20019798_ChIP-Seq_JUKART_Human2.18561682
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.18561682
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.12172249
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11668147
13DROSHA_22980978_ChIP-Seq_HELA_Human2.01923630
14FUS_26573619_Chip-Seq_HEK293_Human1.87684446
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86491725
16NANOG_20526341_ChIP-Seq_ESCs_Human1.86050926
17ERA_21632823_ChIP-Seq_H3396_Human1.83431329
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81259304
19RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.80553938
20ELF1_20517297_ChIP-Seq_JURKAT_Human1.77758858
21WDR5_24793694_ChIP-Seq_LNCAP_Human1.74738187
22ER_23166858_ChIP-Seq_MCF-7_Human1.74465362
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73433851
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.72823829
25RAC3_21632823_ChIP-Seq_H3396_Human1.70432003
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.68013740
27EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.67240368
28TAF15_26573619_Chip-Seq_HEK293_Human1.65411078
29VDR_22108803_ChIP-Seq_LS180_Human1.61079963
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.59339976
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58402081
32MYC_19829295_ChIP-Seq_ESCs_Human1.58388034
33TAF2_19829295_ChIP-Seq_ESCs_Human1.57944045
34AR_25329375_ChIP-Seq_VCAP_Human1.57497073
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56717200
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.56176055
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52456946
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50771100
39BCL6_27268052_Chip-Seq_Bcells_Human1.48836618
40E2F1_20622854_ChIP-Seq_HELA_Human1.48724767
41P300_19829295_ChIP-Seq_ESCs_Human1.48680985
42OCT4_20526341_ChIP-Seq_ESCs_Human1.46798910
43CTCF_27219007_Chip-Seq_Bcells_Human1.45749211
44TDRD3_21172665_ChIP-Seq_MCF-7_Human1.42480442
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.39873166
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39208146
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39022968
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38874496
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37896329
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37887561
51YY1_22570637_ChIP-Seq_MALME-3M_Human1.37475949
52ZNF274_21170338_ChIP-Seq_K562_Hela1.36944891
53TP53_18474530_ChIP-ChIP_U2OS_Human1.36466541
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.36131730
55SMAD3_21741376_ChIP-Seq_ESCs_Human1.33472245
56CTCF_20526341_ChIP-Seq_ESCs_Human1.33240500
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29465486
58BCOR_27268052_Chip-Seq_Bcells_Human1.29359982
59ERG_20517297_ChIP-Seq_VCAP_Human1.29206461
60P300_27268052_Chip-Seq_Bcells_Human1.29107376
61SOX2_19829295_ChIP-Seq_ESCs_Human1.29033225
62NANOG_19829295_ChIP-Seq_ESCs_Human1.29033225
63PHF8_20622854_ChIP-Seq_HELA_Human1.27839135
64RUNX_20019798_ChIP-Seq_JUKART_Human1.26365522
65GBX2_23144817_ChIP-Seq_PC3_Human1.23881927
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22095469
67SMC4_20622854_ChIP-Seq_HELA_Human1.21874291
68TP63_22573176_ChIP-Seq_HFKS_Human1.21850920
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21576931
70RUNX2_22187159_ChIP-Seq_PCA_Human1.21474033
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21230973
72P53_21459846_ChIP-Seq_SAOS-2_Human1.21055882
73CEBPB_22108803_ChIP-Seq_LS180_Human1.20950697
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20651267
75HNFA_21074721_ChIP-Seq_CACO-2_Human1.19904248
76AR_21572438_ChIP-Seq_LNCaP_Human1.19012094
77STAT3_23295773_ChIP-Seq_U87_Human1.17785867
78SMRT_27268052_Chip-Seq_Bcells_Human1.17334504
79RBPJ_21746931_ChIP-Seq_IB4_Human1.17321371
80OCT1_27270436_Chip-Seq_PROSTATE_Human1.17118763
81CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16748839
82SMAD4_21799915_ChIP-Seq_A2780_Human1.16584999
83P68_20966046_ChIP-Seq_HELA_Human1.16413771
84P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.16222759
85KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.15550986
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.13624736
87ETV1_20927104_ChIP-Seq_GIST48_Human1.13107822
88CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.12992998
89HOXB7_26014856_ChIP-Seq_BT474_Human1.10080728
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09802650
91SMAD4_21741376_ChIP-Seq_HESCs_Human1.09774800
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08882909
93TBL1_22424771_ChIP-Seq_293T_Human1.08800125
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.08638767
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08513528
96NFYB_21822215_ChIP-Seq_K562_Human1.07573448
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.02922050
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02922050
99NCOR_22424771_ChIP-Seq_293T_Human1.02223784
100SOX2_22085726_ChIP-Seq_NPCs_Mouse1.01742766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.87164454
2MP0005377_hearing/vestibular/ear_phenot4.87164454
3MP0003698_abnormal_male_reproductive4.32014637
4MP0005670_abnormal_white_adipose3.98032355
5MP0001929_abnormal_gametogenesis3.79483006
6MP0003718_maternal_effect2.64630949
7MP0001348_abnormal_lacrimal_gland2.58817547
8MP0002161_abnormal_fertility/fecundity2.38966541
9MP0000678_abnormal_parathyroid_gland2.30494554
10MP0003011_delayed_dark_adaptation2.13235223
11MP0005410_abnormal_fertilization11.9610643
12MP0002234_abnormal_pharynx_morphology1.99671882
13MP0003646_muscle_fatigue1.99397889
14MP0001968_abnormal_touch/_nociception1.88831071
15MP0005423_abnormal_somatic_nervous1.80017268
16MP0001485_abnormal_pinna_reflex1.74578662
17MP0002132_abnormal_respiratory_system1.74078079
18MP0002210_abnormal_sex_determination1.72174965
19MP0002138_abnormal_hepatobiliary_system1.62524615
20MP0001486_abnormal_startle_reflex1.57589706
21MP0003879_abnormal_hair_cell1.50942832
22MP0002822_catalepsy1.44265330
23MP0005310_abnormal_salivary_gland1.44182175
24MP0001145_abnormal_male_reproductive1.43253602
25MP0001765_abnormal_ion_homeostasis1.42942694
26MP0000653_abnormal_sex_gland1.41633201
27MP0008877_abnormal_DNA_methylation1.35861713
28MP0005379_endocrine/exocrine_gland_phen1.34056749
29MP0002249_abnormal_larynx_morphology1.32873904
30MP0002735_abnormal_chemical_nociception1.28879305
31MP0002282_abnormal_trachea_morphology1.28363484
32MP0005551_abnormal_eye_electrophysiolog1.24604093
33MP0001963_abnormal_hearing_physiology1.23569057
34MP0004742_abnormal_vestibular_system1.22568117
35MP0004510_myositis1.21083124
36MP0005395_other_phenotype1.21021210
37MP0004859_abnormal_synaptic_plasticity1.19158883
38MP0005451_abnormal_body_composition1.09802607
39MP0000026_abnormal_inner_ear1.07994141
40MP0005167_abnormal_blood-brain_barrier1.04649249
41MP0009053_abnormal_anal_canal1.02034517
42MP0001879_abnormal_lymphatic_vessel1.00818102
43MP0002127_abnormal_cardiovascular_syste0.99758980
44MP0000534_abnormal_ureter_morphology0.96755606
45MP0002733_abnormal_thermal_nociception0.96720964
46MP0001501_abnormal_sleep_pattern0.95661927
47MP0006292_abnormal_olfactory_placode0.94306121
48MP0002229_neurodegeneration0.94011515
49MP0001905_abnormal_dopamine_level0.93822492
50MP0002272_abnormal_nervous_system0.91465681
51MP0002067_abnormal_sensory_capabilities0.84438181
52MP0004085_abnormal_heartbeat0.83023610
53MP0001970_abnormal_pain_threshold0.79923740
54MP0005248_abnormal_Harderian_gland0.78487906
55MP0005636_abnormal_mineral_homeostasis0.77204923
56MP0000955_abnormal_spinal_cord0.77166374
57MP0000230_abnormal_systemic_arterial0.74498816
58MP0004484_altered_response_of0.72252378
59MP0005253_abnormal_eye_physiology0.71945926
60MP0002736_abnormal_nociception_after0.70501420
61MP0001666_abnormal_nutrient_absorption0.70286801
62MP0003880_abnormal_central_pattern0.69384397
63MP0001984_abnormal_olfaction0.69353899
64MP0008569_lethality_at_weaning0.69148459
65MP0002572_abnormal_emotion/affect_behav0.68389601
66MP0000681_abnormal_thyroid_gland0.68278417
67MP0009745_abnormal_behavioral_response0.67514768
68MP0009697_abnormal_copulation0.67291011
69MP0002557_abnormal_social/conspecific_i0.66905989
70MP0000049_abnormal_middle_ear0.66325974
71MP0001440_abnormal_grooming_behavior0.65832065
72MP0008995_early_reproductive_senescence0.64316964
73MP0002734_abnormal_mechanical_nocicepti0.62439605
74MP0009764_decreased_sensitivity_to0.60685656
75MP0005647_abnormal_sex_gland0.59061083
76MP0009046_muscle_twitch0.58428992
77MP0002928_abnormal_bile_duct0.56670486
78MP0010368_abnormal_lymphatic_system0.54801568
79MP0000613_abnormal_salivary_gland0.53725862
80MP0000249_abnormal_blood_vessel0.51850879
81MP0005083_abnormal_biliary_tract0.51268653
82MP0009115_abnormal_fat_cell0.50462522
83MP0003699_abnormal_female_reproductive0.50380546
84MP0002653_abnormal_ependyma_morphology0.50127372
85MP0006276_abnormal_autonomic_nervous0.49744162
86MP0000470_abnormal_stomach_morphology0.49032500
87MP0003137_abnormal_impulse_conducting0.48745605
88MP0003119_abnormal_digestive_system0.48396603
89MP0008775_abnormal_heart_ventricle0.45204163
90MP0010386_abnormal_urinary_bladder0.45087028
91MP0003635_abnormal_synaptic_transmissio0.45053679
92MP0005367_renal/urinary_system_phenotyp0.44420109
93MP0000516_abnormal_urinary_system0.44420109
94MP0005535_abnormal_body_temperature0.41537695
95MP0004036_abnormal_muscle_relaxation0.40467347
96MP0005408_hypopigmentation0.39904426
97MP0005646_abnormal_pituitary_gland0.37508098
98MP0005595_abnormal_vascular_smooth0.37435690
99MP0003631_nervous_system_phenotype0.36364524
100MP0004142_abnormal_muscle_tone0.34514390

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.91964413
2Absent/shortened dynein arms (HP:0200106)6.44676577
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.44676577
4Attenuation of retinal blood vessels (HP:0007843)5.40633018
5Bony spicule pigmentary retinopathy (HP:0007737)5.26198556
6Abnormal ciliary motility (HP:0012262)5.22408657
7Abnormal respiratory motile cilium physiology (HP:0012261)4.88048548
8Abnormal respiratory epithelium morphology (HP:0012253)4.70577550
9Abnormal respiratory motile cilium morphology (HP:0005938)4.70577550
10Bell-shaped thorax (HP:0001591)4.70096887
11Abnormal rod and cone electroretinograms (HP:0008323)4.57880778
12Hypoplastic ischia (HP:0003175)4.50866548
13Asymmetric septal hypertrophy (HP:0001670)4.34828716
14Infertility (HP:0000789)4.23880471
15Chronic hepatic failure (HP:0100626)4.07467531
16Tubulointerstitial nephritis (HP:0001970)4.04056651
17Resting tremor (HP:0002322)4.02412841
18Enlarged epiphyses (HP:0010580)3.93801992
19Abnormality of the ischium (HP:0003174)3.89064527
20Hyperkalemia (HP:0002153)3.87925093
21Potter facies (HP:0002009)3.87323331
22Facial shape deformation (HP:0011334)3.87323331
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.86550500
24Abnormality of macular pigmentation (HP:0008002)3.82851830
25Azoospermia (HP:0000027)3.80788653
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.74385647
27Male infertility (HP:0003251)3.72424591
28Nasal polyposis (HP:0100582)3.59755101
29Abnormal spermatogenesis (HP:0008669)3.41925431
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.34290845
31Nephronophthisis (HP:0000090)3.08108512
32Aplasia/Hypoplasia of the earlobes (HP:0009906)3.02769826
33Cone-rod dystrophy (HP:0000548)2.93577783
34Generalized aminoaciduria (HP:0002909)2.92654139
35Postural instability (HP:0002172)2.92124899
36Abnormality of the nasal mucosa (HP:0000433)2.91548347
37Hypoplasia of the thymus (HP:0000778)2.90484660
38Abnormal urine output (HP:0012590)2.90456252
39Impulsivity (HP:0100710)2.88703459
40Rhinitis (HP:0012384)2.85994464
41Polydipsia (HP:0001959)2.77610349
42Abnormal drinking behavior (HP:0030082)2.77610349
43Epiphyseal dysplasia (HP:0002656)2.71298111
44Abnormality of the renal medulla (HP:0100957)2.64209374
45Congenital sensorineural hearing impairment (HP:0008527)2.52279875
46Polyuria (HP:0000103)2.50464208
47Unilateral renal agenesis (HP:0000122)2.50296557
48Congenital malformation of the right heart (HP:0011723)2.50277366
49Double outlet right ventricle (HP:0001719)2.50277366
50Abnormality of renal excretion (HP:0011036)2.46035184
51Progressive cerebellar ataxia (HP:0002073)2.45791676
52Abnormality of potassium homeostasis (HP:0011042)2.44020541
53Renal dysplasia (HP:0000110)2.40915112
54Stage 5 chronic kidney disease (HP:0003774)2.40780847
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.39794724
56Absent epiphyses (HP:0010577)2.39794724
57Abnormality of the aortic arch (HP:0012303)2.38556925
58Portal hypertension (HP:0001409)2.31197462
59Hypophosphatemic rickets (HP:0004912)2.27061410
60Decreased central vision (HP:0007663)2.25273205
61Tubulointerstitial abnormality (HP:0001969)2.22884592
62Amelogenesis imperfecta (HP:0000705)2.20538781
63Occipital encephalocele (HP:0002085)2.19486562
64Abnormality of the costochondral junction (HP:0000919)2.18572068
65Bronchiectasis (HP:0002110)2.17250449
66Abnormality of dental color (HP:0011073)2.14450484
67Truncal obesity (HP:0001956)2.10843194
68Abnormality of the hepatic vasculature (HP:0006707)2.09517612
69Abnormality of the epiphysis of the femoral head (HP:0010574)2.08487304
70Abnormality of the pubic bones (HP:0003172)2.07042692
71Progressive sensorineural hearing impairment (HP:0000408)2.05808477
72Pancreatic fibrosis (HP:0100732)2.05749274
73Tetany (HP:0001281)2.05464981
74Abnormality of the parathyroid morphology (HP:0011766)2.01848719
75Protuberant abdomen (HP:0001538)2.01090088
76Flattened epiphyses (HP:0003071)1.97015747
77Pancreatic cysts (HP:0001737)1.96981128
78Chronic bronchitis (HP:0004469)1.95637310
79Renal Fanconi syndrome (HP:0001994)1.93404544
80Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.92673211
81Abnormality of femoral epiphyses (HP:0006499)1.92673211
82Recurrent pneumonia (HP:0006532)1.91775062
83Abnormality of the femoral head (HP:0003368)1.86747630
84Optic nerve hypoplasia (HP:0000609)1.83517772
85Photophobia (HP:0000613)1.83323608
86Tubular atrophy (HP:0000092)1.82837650
87Bulbous nose (HP:0000414)1.80466500
88Sclerocornea (HP:0000647)1.80042102
89Hypoalphalipoproteinemia (HP:0003233)1.79560980
90Insulin-resistant diabetes mellitus (HP:0000831)1.77682725
91Ventricular tachycardia (HP:0004756)1.74141376
92Osteomalacia (HP:0002749)1.73444087
93Flat capital femoral epiphysis (HP:0003370)1.72240510
94Renovascular hypertension (HP:0100817)1.70729206
95Cerebellar dysplasia (HP:0007033)1.70348668
96Short ribs (HP:0000773)1.70335639
97Mixed hearing impairment (HP:0000410)1.69590284
98Hyponatremia (HP:0002902)1.69407770
99Cystic liver disease (HP:0006706)1.69251483
100Bradycardia (HP:0001662)1.67873428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.23648292
2TESK16.02842452
3DDR25.57939452
4INSRR4.22252222
5MAP4K23.39308233
6STK382.82315550
7PLK22.51131057
8MAPK152.40295584
9STK38L2.25472455
10PNCK1.89216873
11TIE11.85631178
12BRD41.84253811
13FRK1.82754390
14MST1R1.78500721
15PIK3CG1.74380375
16WNK11.72855133
17CAMK1G1.65946201
18ZAK1.57657350
19PRKD31.54748293
20PINK11.49967267
21PTK2B1.44794624
22WNK41.29492037
23CDK71.27870428
24PDPK11.27442046
25TLK11.27374673
26PDK11.23718370
27MAP3K91.19659435
28KSR21.11815170
29CDK121.08936322
30AKT31.02613494
31BMPR1B1.02579377
32ADRBK21.01190559
33STK390.97568175
34DYRK1B0.89785622
35BRAF0.87420955
36MAP3K20.87067315
37ARAF0.75361778
38NEK60.74695440
39LATS10.72522245
40ACVR1B0.71375670
41PRKG10.69012034
42MAP2K20.66199638
43MUSK0.65112254
44PRKG20.60987004
45TXK0.60716189
46RIPK40.60242972
47SIK20.60134807
48GRK10.56491434
49CAMK1D0.55429770
50RPS6KA20.54243103
51TNIK0.52416532
52ROCK10.52181700
53TEC0.50598471
54PRKAA20.50038520
55TAOK30.49218988
56DYRK30.48409325
57RPS6KA10.46999836
58MAP3K40.45957067
59KIT0.44216997
60CAMK10.43461114
61MAP3K130.42739446
62JAK30.42700927
63NTRK30.42439934
64SGK2230.41760991
65SGK4940.41760991
66CDK40.40512468
67FER0.39791476
68CDK30.38981561
69NUAK10.37373157
70MAP3K80.36335181
71OXSR10.36140849
72PRKCG0.35585511
73MAPK10.34009930
74GSK3B0.33938047
75MAPK110.33832715
76MAP3K110.33584292
77TRPM70.33396482
78RPS6KA60.32039966
79MET0.30391054
80CDK20.29823337
81MAP3K10.26977569
82TNK20.26938539
83RPS6KC10.26315477
84RPS6KL10.26315477
85IKBKB0.25952476
86CDK10.25872381
87PRKCE0.25652274
88SYK0.25157561
89MAPK80.23540883
90UHMK10.23510950
91ITK0.22836499
92PRKCB0.21800749
93PRKCQ0.19350173
94LATS20.19311222
95MAP2K70.18271640
96STK160.17980247
97PRKCZ0.17664331
98PRKACA0.16367054
99CAMK2A0.15809911
100CAMK40.15762564

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.42208384
2Fatty acid biosynthesis_Homo sapiens_hsa000615.39737016
3Olfactory transduction_Homo sapiens_hsa047403.75999897
4Butanoate metabolism_Homo sapiens_hsa006502.86374160
5Allograft rejection_Homo sapiens_hsa053302.30071821
6Autoimmune thyroid disease_Homo sapiens_hsa053202.23004517
7Graft-versus-host disease_Homo sapiens_hsa053322.20832450
8Type I diabetes mellitus_Homo sapiens_hsa049402.11456713
9Taste transduction_Homo sapiens_hsa047421.91357565
10Dorso-ventral axis formation_Homo sapiens_hsa043201.87445344
11Glycerophospholipid metabolism_Homo sapiens_hsa005641.83131591
12Phototransduction_Homo sapiens_hsa047441.80608427
13Antigen processing and presentation_Homo sapiens_hsa046121.73920725
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65447379
15Selenocompound metabolism_Homo sapiens_hsa004501.42311515
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38986385
17Type II diabetes mellitus_Homo sapiens_hsa049301.32741993
18Fatty acid degradation_Homo sapiens_hsa000711.31230930
19Salivary secretion_Homo sapiens_hsa049701.26608999
20Viral myocarditis_Homo sapiens_hsa054161.19730298
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18404305
22ABC transporters_Homo sapiens_hsa020101.17306713
23Phenylalanine metabolism_Homo sapiens_hsa003601.13942482
24Morphine addiction_Homo sapiens_hsa050321.10653775
25Calcium signaling pathway_Homo sapiens_hsa040201.04499609
26Linoleic acid metabolism_Homo sapiens_hsa005911.04415397
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98869193
28Arginine and proline metabolism_Homo sapiens_hsa003300.98766189
29Nicotine addiction_Homo sapiens_hsa050330.95471805
30Protein digestion and absorption_Homo sapiens_hsa049740.95040913
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93860415
32Fatty acid metabolism_Homo sapiens_hsa012120.93737852
33Circadian entrainment_Homo sapiens_hsa047130.92695053
34Adipocytokine signaling pathway_Homo sapiens_hsa049200.91864487
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84692930
36Nitrogen metabolism_Homo sapiens_hsa009100.83703410
37RNA transport_Homo sapiens_hsa030130.82339170
38Vascular smooth muscle contraction_Homo sapiens_hsa042700.82216731
39Retinol metabolism_Homo sapiens_hsa008300.79710127
40cAMP signaling pathway_Homo sapiens_hsa040240.79295924
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.78639208
42Serotonergic synapse_Homo sapiens_hsa047260.78590300
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76623369
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76346234
45Basal transcription factors_Homo sapiens_hsa030220.75737940
46Endocytosis_Homo sapiens_hsa041440.75294051
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.72392120
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.71772814
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69703060
50Cardiac muscle contraction_Homo sapiens_hsa042600.68959576
51Synaptic vesicle cycle_Homo sapiens_hsa047210.68447466
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68015999
53Glutamatergic synapse_Homo sapiens_hsa047240.67206236
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66684777
55PPAR signaling pathway_Homo sapiens_hsa033200.65273891
56Gastric acid secretion_Homo sapiens_hsa049710.65043396
57Bile secretion_Homo sapiens_hsa049760.64816558
58Influenza A_Homo sapiens_hsa051640.64351632
59Hedgehog signaling pathway_Homo sapiens_hsa043400.64262262
60Arginine biosynthesis_Homo sapiens_hsa002200.63947652
61Fat digestion and absorption_Homo sapiens_hsa049750.62678081
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62399502
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61826008
64Oocyte meiosis_Homo sapiens_hsa041140.61138418
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.60233182
66Glycerolipid metabolism_Homo sapiens_hsa005610.60116302
67Inositol phosphate metabolism_Homo sapiens_hsa005620.58818711
68Purine metabolism_Homo sapiens_hsa002300.58775915
69Asthma_Homo sapiens_hsa053100.56741408
70Renin secretion_Homo sapiens_hsa049240.56717862
71Tryptophan metabolism_Homo sapiens_hsa003800.56271039
72Insulin secretion_Homo sapiens_hsa049110.56237488
73Chemical carcinogenesis_Homo sapiens_hsa052040.53485571
74Renin-angiotensin system_Homo sapiens_hsa046140.53046165
75Cholinergic synapse_Homo sapiens_hsa047250.52152333
76Tyrosine metabolism_Homo sapiens_hsa003500.50345645
77Oxytocin signaling pathway_Homo sapiens_hsa049210.50301794
78Estrogen signaling pathway_Homo sapiens_hsa049150.48661433
79Pancreatic secretion_Homo sapiens_hsa049720.46261748
80MAPK signaling pathway_Homo sapiens_hsa040100.44527036
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42820602
82GABAergic synapse_Homo sapiens_hsa047270.42068344
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41578752
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40768310
85beta-Alanine metabolism_Homo sapiens_hsa004100.37015349
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36393700
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35534121
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35405030
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32185204
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30704147
91Long-term depression_Homo sapiens_hsa047300.29030711
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28800273
93Fanconi anemia pathway_Homo sapiens_hsa034600.28722305
94Propanoate metabolism_Homo sapiens_hsa006400.28556357
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25586844
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24803685
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.24709721
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24327307
99Herpes simplex infection_Homo sapiens_hsa051680.22370799
100Arachidonic acid metabolism_Homo sapiens_hsa005900.22054363

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