GOLGA8H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.55863500
2single strand break repair (GO:0000012)5.83490032
3protein targeting to Golgi (GO:0000042)5.80502962
4establishment of protein localization to Golgi (GO:0072600)5.77468157
5retrograde transport, vesicle recycling within Golgi (GO:0000301)5.66237539
6acrosome reaction (GO:0007340)5.65120546
7fusion of sperm to egg plasma membrane (GO:0007342)5.43280278
8chromosome condensation (GO:0030261)5.35269638
9response to pheromone (GO:0019236)5.34058254
10DNA packaging (GO:0006323)5.33801722
11spermatid development (GO:0007286)5.33163450
12sperm capacitation (GO:0048240)5.07609414
13seminiferous tubule development (GO:0072520)4.92427327
14regulation of cilium movement (GO:0003352)4.82294338
15multicellular organism reproduction (GO:0032504)4.78355599
16positive regulation of Rab GTPase activity (GO:0032851)4.74073790
17regulation of Rab GTPase activity (GO:0032313)4.74073790
18RNA destabilization (GO:0050779)4.58939419
19reproduction (GO:0000003)4.53235596
20sexual reproduction (GO:0019953)4.48934594
21response to peptidoglycan (GO:0032494)4.44288460
22cell wall macromolecule catabolic process (GO:0016998)4.23422201
23microtubule depolymerization (GO:0007019)4.20524473
24regulation of ARF GTPase activity (GO:0032312)4.19195924
25regulation of T-helper 2 cell differentiation (GO:0045628)4.16455966
26regulation of G0 to G1 transition (GO:0070316)4.06960204
27cell wall macromolecule metabolic process (GO:0044036)4.03290589
28phosphatidylethanolamine biosynthetic process (GO:0006646)4.00410616
29centriole replication (GO:0007099)3.90733672
30protein localization to Golgi apparatus (GO:0034067)3.90215922
31plasma membrane fusion (GO:0045026)3.88857884
32protein polyglutamylation (GO:0018095)3.87954064
33spermatid nucleus differentiation (GO:0007289)3.87710599
34phosphatidylethanolamine metabolic process (GO:0046337)3.85403738
35histone lysine demethylation (GO:0070076)3.84651660
36histone demethylation (GO:0016577)3.83750353
37sperm-egg recognition (GO:0035036)3.82985155
38regulation of microtubule-based movement (GO:0060632)3.82875436
39brain morphogenesis (GO:0048854)3.82335066
40cilium or flagellum-dependent cell motility (GO:0001539)3.73204030
41dendritic spine organization (GO:0097061)3.66468243
42left/right pattern formation (GO:0060972)3.66427482
43spermatogenesis (GO:0007283)3.65230987
44centriole assembly (GO:0098534)3.64137893
45auditory behavior (GO:0031223)3.63737602
46male gamete generation (GO:0048232)3.62764249
47axonemal dynein complex assembly (GO:0070286)3.61931729
48maintenance of gastrointestinal epithelium (GO:0030277)3.59803795
49chromatin silencing (GO:0006342)3.49806976
50calcium ion-dependent exocytosis (GO:0017156)3.44864430
51histone H3-K9 demethylation (GO:0033169)3.41538955
52regulation of female gonad development (GO:2000194)3.41308439
53protein dealkylation (GO:0008214)3.40187099
54protein demethylation (GO:0006482)3.40187099
55immunoglobulin mediated immune response (GO:0016064)3.39027951
56cell-cell recognition (GO:0009988)3.38960465
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38947435
58peptide catabolic process (GO:0043171)3.34840293
59lipid translocation (GO:0034204)3.30869797
60phospholipid translocation (GO:0045332)3.30869797
61gamete generation (GO:0007276)3.29485581
62microtubule polymerization or depolymerization (GO:0031109)3.28639312
63microtubule severing (GO:0051013)3.26923807
64dendritic spine morphogenesis (GO:0060997)3.25673447
65mitochondrion transport along microtubule (GO:0047497)3.21945453
66establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.21945453
67mechanosensory behavior (GO:0007638)3.19239246
68germ cell development (GO:0007281)3.17715907
69peptidyl-threonine dephosphorylation (GO:0035970)3.11430872
70single fertilization (GO:0007338)3.11276545
71binding of sperm to zona pellucida (GO:0007339)3.11111211
72negative regulation of granulocyte differentiation (GO:0030853)3.08902649
73response to auditory stimulus (GO:0010996)3.07358292
74neurotransmitter-gated ion channel clustering (GO:0072578)3.03571805
75thrombin receptor signaling pathway (GO:0070493)3.03165038
76epithelial cilium movement (GO:0003351)3.02476725
77response to vitamin A (GO:0033189)2.97942478
78positive regulation of type 2 immune response (GO:0002830)2.93727887
79cellular process involved in reproduction in multicellular organism (GO:0022412)2.93027269
80coronary vasculature morphogenesis (GO:0060977)2.90940237
81epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89575980
82positive regulation of T-helper cell differentiation (GO:0045624)2.86159552
83positive regulation of protein sumoylation (GO:0033235)2.85144916
84cellular extravasation (GO:0045123)2.84006434
85epithelial cell fate commitment (GO:0072148)2.82956696
86cell volume homeostasis (GO:0006884)2.80061337
87negative regulation of gene expression, epigenetic (GO:0045814)2.76370632
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.74294397
89regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74129217
90L-fucose catabolic process (GO:0042355)2.71356276
91fucose catabolic process (GO:0019317)2.71356276
92L-fucose metabolic process (GO:0042354)2.71356276
93cranial nerve morphogenesis (GO:0021602)2.70277063
94protein-DNA complex disassembly (GO:0032986)2.69000391
95nucleosome disassembly (GO:0006337)2.69000391
96poly(A)+ mRNA export from nucleus (GO:0016973)2.66948399
97multicellular organismal reproductive process (GO:0048609)2.63573987
98detection of light stimulus involved in sensory perception (GO:0050962)2.63006904
99detection of light stimulus involved in visual perception (GO:0050908)2.63006904
100B cell mediated immunity (GO:0019724)2.59971847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.35724758
2EZH2_22144423_ChIP-Seq_EOC_Human3.04743911
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.81202022
4DROSHA_22980978_ChIP-Seq_HELA_Human2.55898047
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.43346373
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.37397728
7WDR5_24793694_ChIP-Seq_LNCAP_Human2.37187529
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.35497690
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.20438940
10BCL6_27268052_Chip-Seq_Bcells_Human2.08976548
11P68_20966046_ChIP-Seq_HELA_Human2.06537824
12E2F1_20622854_ChIP-Seq_HELA_Human2.03393199
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01873928
14EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.01175021
15ELF1_20517297_ChIP-Seq_JURKAT_Human1.98150455
16SMC4_20622854_ChIP-Seq_HELA_Human1.97565513
17BCOR_27268052_Chip-Seq_Bcells_Human1.93768742
18PHF8_20622854_ChIP-Seq_HELA_Human1.92876372
19VDR_21846776_ChIP-Seq_THP-1_Human1.90265954
20LXR_22292898_ChIP-Seq_THP-1_Human1.90101801
21RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.87741443
22SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.83485085
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83217142
24SCL_19346495_ChIP-Seq_HPC-7_Human1.80044864
25RAC3_21632823_ChIP-Seq_H3396_Human1.77924524
26VDR_24763502_ChIP-Seq_THP-1_Human1.73307609
27VDR_24787735_ChIP-Seq_THP-1_Human1.71287702
28ERA_21632823_ChIP-Seq_H3396_Human1.70700290
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68046483
30SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.67334916
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62492872
32RUNX_20019798_ChIP-Seq_JUKART_Human1.62166368
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61264526
34SPI1_20517297_ChIP-Seq_HL60_Human1.60385366
35P300_27268052_Chip-Seq_Bcells_Human1.59021087
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56023437
37GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55782224
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54311664
39SPI1_23127762_ChIP-Seq_K562_Human1.50675336
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50107835
41CTCF_27219007_Chip-Seq_Bcells_Human1.49024244
42OCT4_19829295_ChIP-Seq_ESCs_Human1.48198726
43TP53_22127205_ChIP-Seq_IMR90_Human1.45862543
44GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44850071
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42820850
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42291363
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42291363
48TAF2_19829295_ChIP-Seq_ESCs_Human1.41982796
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38387820
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.37311148
51KDM2B_26808549_Chip-Seq_DND41_Human1.35726880
52ZNF274_21170338_ChIP-Seq_K562_Hela1.33331276
53EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.32281020
54TP63_22573176_ChIP-Seq_HFKS_Human1.32140058
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31637986
56SA1_27219007_Chip-Seq_Bcells_Human1.31245688
57NANOG_20526341_ChIP-Seq_ESCs_Human1.30976104
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29311603
59OCT4_20526341_ChIP-Seq_ESCs_Human1.27954958
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26994407
61MYC_19829295_ChIP-Seq_ESCs_Human1.26711886
62TCF7_22412390_ChIP-Seq_EML_Mouse1.25651671
63MAF_26560356_Chip-Seq_TH2_Human1.24638567
64GATA3_27048872_Chip-Seq_THYMUS_Human1.23608602
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22456518
66MAF_26560356_Chip-Seq_TH1_Human1.17918271
67ER_23166858_ChIP-Seq_MCF-7_Human1.17128313
68CTCF_20526341_ChIP-Seq_ESCs_Human1.17119386
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14390318
70GATA1_19941826_ChIP-Seq_K562_Human1.12762998
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.12409292
72P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.10411580
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09773375
74MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09563494
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08969250
76CBP_20019798_ChIP-Seq_JUKART_Human1.08969250
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.08570240
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.07630823
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07619946
80CEBPB_22108803_ChIP-Seq_LS180_Human1.06821796
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.05113033
82STAT1_20625510_ChIP-Seq_HELA_Human1.02946041
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.02418289
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01812933
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.01493452
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.01234672
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00714980
88BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.00511782
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00326980
90OCT1_27270436_Chip-Seq_PROSTATE_Human0.96190664
91GATA3_26560356_Chip-Seq_TH1_Human0.96113598
92SMRT_27268052_Chip-Seq_Bcells_Human0.95631417
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95409147
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95163399
95P53_21459846_ChIP-Seq_SAOS-2_Human0.94881842
96MYB_26560356_Chip-Seq_TH2_Human0.94756814
97TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.94636837
98FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94054212
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93378081
100MYB_26560356_Chip-Seq_TH1_Human0.93163113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.17255278
2MP0009278_abnormal_bone_marrow3.69582653
3MP0000465_gastrointestinal_hemorrhage3.59659243
4MP0005451_abnormal_body_composition3.09702258
5MP0003172_abnormal_lysosome_physiology2.91736837
6MP0003698_abnormal_male_reproductive2.78607602
7MP0001929_abnormal_gametogenesis2.61527800
8MP0003436_decreased_susceptibility_to2.45896450
9MP0005377_hearing/vestibular/ear_phenot2.45626407
10MP0003878_abnormal_ear_physiology2.45626407
11MP0001835_abnormal_antigen_presentation2.38961159
12MP0001348_abnormal_lacrimal_gland2.37155833
13MP0001545_abnormal_hematopoietic_system2.18487826
14MP0005397_hematopoietic_system_phenotyp2.18487826
15MP0003718_maternal_effect2.03428453
16MP0005670_abnormal_white_adipose1.96109301
17MP0003123_paternal_imprinting1.94415403
18MP0009764_decreased_sensitivity_to1.82631737
19MP0001485_abnormal_pinna_reflex1.70656598
20MP0004043_abnormal_pH_regulation1.70392861
21MP0003879_abnormal_hair_cell1.67252025
22MP0003091_abnormal_cell_migration1.62635611
23MP0005464_abnormal_platelet_physiology1.60572658
24MP0009840_abnormal_foam_cell1.60103710
25MP0003283_abnormal_digestive_organ1.57545523
26MP0000678_abnormal_parathyroid_gland1.57440512
27MP0004084_abnormal_cardiac_muscle1.55879663
28MP0001765_abnormal_ion_homeostasis1.54816802
29MP0002161_abnormal_fertility/fecundity1.54378298
30MP0009115_abnormal_fat_cell1.54102683
31MP0002822_catalepsy1.53377052
32MP0001986_abnormal_taste_sensitivity1.50954689
33MP0002127_abnormal_cardiovascular_syste1.50365083
34MP0006292_abnormal_olfactory_placode1.47858877
35MP0004133_heterotaxia1.46808124
36MP0009697_abnormal_copulation1.45729268
37MP0005058_abnormal_lysosome_morphology1.40301461
38MP0008995_early_reproductive_senescence1.36290370
39MP0002132_abnormal_respiratory_system1.35144137
40MP0005647_abnormal_sex_gland1.33169789
41MP0002928_abnormal_bile_duct1.31847668
42MP0002148_abnormal_hypersensitivity_rea1.28402599
43MP0009785_altered_susceptibility_to1.25939121
44MP0000681_abnormal_thyroid_gland1.24578365
45MP0002419_abnormal_innate_immunity1.20745588
46MP0002733_abnormal_thermal_nociception1.20135001
47MP0005025_abnormal_response_to1.19862799
48MP0002210_abnormal_sex_determination1.15810182
49MP0005076_abnormal_cell_differentiation1.15049389
50MP0003329_amyloid_beta_deposits1.11545071
51MP0008004_abnormal_stomach_pH1.08120532
52MP0000604_amyloidosis1.05053875
53MP0002009_preneoplasia1.04505596
54MP0004808_abnormal_hematopoietic_stem1.01324947
55MP0005084_abnormal_gallbladder_morpholo0.97943801
56MP0003121_genomic_imprinting0.97544143
57MP0008007_abnormal_cellular_replicative0.96166905
58MP0004036_abnormal_muscle_relaxation0.94766417
59MP0010155_abnormal_intestine_physiology0.93718465
60MP0005394_taste/olfaction_phenotype0.92880057
61MP0005499_abnormal_olfactory_system0.92880057
62MP0005167_abnormal_blood-brain_barrier0.92654304
63MP0001145_abnormal_male_reproductive0.91423432
64MP0004782_abnormal_surfactant_physiolog0.90027196
65MP0005000_abnormal_immune_tolerance0.87934996
66MP0000653_abnormal_sex_gland0.87496397
67MP0002166_altered_tumor_susceptibility0.87429102
68MP0003075_altered_response_to0.86850895
69MP0005535_abnormal_body_temperature0.85111023
70MP0002452_abnormal_antigen_presenting0.84648283
71MP0001963_abnormal_hearing_physiology0.81203788
72MP0002723_abnormal_immune_serum0.81201904
73MP0008469_abnormal_protein_level0.78712261
74MP0005395_other_phenotype0.77831450
75MP0001501_abnormal_sleep_pattern0.75262093
76MP0001800_abnormal_humoral_immune0.74581591
77MP0003787_abnormal_imprinting0.73807837
78MP0003943_abnormal_hepatobiliary_system0.73619875
79MP0001666_abnormal_nutrient_absorption0.72034459
80MP0003866_abnormal_defecation0.71194311
81MP0002420_abnormal_adaptive_immunity0.70570291
82MP0003646_muscle_fatigue0.68989015
83MP0000470_abnormal_stomach_morphology0.68933226
84MP0003699_abnormal_female_reproductive0.67445500
85MP0001819_abnormal_immune_cell0.67303194
86MP0002722_abnormal_immune_system0.65723052
87MP0005379_endocrine/exocrine_gland_phen0.63945738
88MP0005220_abnormal_exocrine_pancreas0.63798560
89MP0001529_abnormal_vocalization0.63755439
90MP0008789_abnormal_olfactory_epithelium0.63422524
91MP0000313_abnormal_cell_death0.63209047
92MP0002398_abnormal_bone_marrow0.63185326
93MP0001533_abnormal_skeleton_physiology0.63018812
94MP0008961_abnormal_basal_metabolism0.62974006
95MP0002229_neurodegeneration0.62462449
96MP0010307_abnormal_tumor_latency0.60963583
97MP0001790_abnormal_immune_system0.60873266
98MP0005387_immune_system_phenotype0.60873266
99MP0005621_abnormal_cell_physiology0.58106226
100MP0003828_pulmonary_edema0.57857642

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)6.42462833
2Hyperkalemia (HP:0002153)4.98963222
3Severe visual impairment (HP:0001141)4.50116059
4Enlarged epiphyses (HP:0010580)3.99195376
5Male infertility (HP:0003251)3.71337737
6Protruding tongue (HP:0010808)3.64029003
7Impulsivity (HP:0100710)3.61260657
8Clumsiness (HP:0002312)3.19097421
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.18914268
10Bony spicule pigmentary retinopathy (HP:0007737)3.12936931
11Absent speech (HP:0001344)3.12759387
12Attenuation of retinal blood vessels (HP:0007843)2.99555906
13Widely spaced teeth (HP:0000687)2.98649948
14Thin bony cortex (HP:0002753)2.90091364
15Cone-rod dystrophy (HP:0000548)2.89070955
16Palpebral edema (HP:0100540)2.82166375
17Elevated erythrocyte sedimentation rate (HP:0003565)2.79362819
18Hypophosphatemic rickets (HP:0004912)2.76186940
19Tubulointerstitial abnormality (HP:0001969)2.72511998
20Flat occiput (HP:0005469)2.67341836
21Truncal obesity (HP:0001956)2.58877229
22Asymmetric septal hypertrophy (HP:0001670)2.57474899
23Abnormality of the columella (HP:0009929)2.56917027
24Abnormality of the fingertips (HP:0001211)2.52400946
25Delayed CNS myelination (HP:0002188)2.46599266
26Abnormal rod and cone electroretinograms (HP:0008323)2.41749641
27Pili torti (HP:0003777)2.41464521
28Stomatitis (HP:0010280)2.38818039
29Intestinal fistula (HP:0100819)2.38363528
30Abnormality of the costochondral junction (HP:0000919)2.37631484
31Stereotypic behavior (HP:0000733)2.36766116
32Abnormality of DNA repair (HP:0003254)2.33773705
33Increased cerebral lipofuscin (HP:0011813)2.30281718
34Delayed epiphyseal ossification (HP:0002663)2.29495466
35Intellectual disability, severe (HP:0010864)2.28125268
36Abnormality of macrophages (HP:0004311)2.26138080
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.24084120
38Widely patent fontanelles and sutures (HP:0004492)2.21980426
39Gingival bleeding (HP:0000225)2.20200495
40Polycystic kidney dysplasia (HP:0000113)2.19960444
41Broad face (HP:0000283)2.19872291
42Abnormality of the periventricular white matter (HP:0002518)2.19357266
43Abnormality of the renal medulla (HP:0100957)2.18102153
44Prolonged bleeding time (HP:0003010)2.17994048
45Heterotopia (HP:0002282)2.17017766
46Retinal dysplasia (HP:0007973)2.16581412
47Intellectual disability, progressive (HP:0006887)2.12431413
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12171269
49Infertility (HP:0000789)2.11365012
50Thoracic kyphosis (HP:0002942)2.10789922
51Abnormality of the parathyroid morphology (HP:0011766)2.10508934
52Cellulitis (HP:0100658)2.06454141
53Gastrointestinal infarctions (HP:0005244)2.04224696
54Rectal fistula (HP:0100590)2.03942949
55Rectovaginal fistula (HP:0000143)2.03942949
56Hypoplastic ischia (HP:0003175)2.02847273
57Vacuolated lymphocytes (HP:0001922)2.02710214
58Periorbital edema (HP:0100539)2.02385461
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02313455
60Colitis (HP:0002583)2.02302492
61Myositis (HP:0100614)2.01952843
62Excessive salivation (HP:0003781)1.99169662
63Absent/shortened dynein arms (HP:0200106)1.98877249
64Dynein arm defect of respiratory motile cilia (HP:0012255)1.98877249
65Drooling (HP:0002307)1.98678192
66Increased mean platelet volume (HP:0011877)1.95305827
67Facial edema (HP:0000282)1.93015259
68Progressive hearing impairment (HP:0001730)1.92927501
69Epiphyseal dysplasia (HP:0002656)1.90347547
70Abnormal ciliary motility (HP:0012262)1.89274310
71Intellectual disability, moderate (HP:0002342)1.88315237
72Long eyelashes (HP:0000527)1.87613872
73Abnormal platelet volume (HP:0011876)1.87360059
74Macroglossia (HP:0000158)1.85441658
75Aplasia/Hypoplasia of the earlobes (HP:0009906)1.84717911
76Facial shape deformation (HP:0011334)1.84421983
77Potter facies (HP:0002009)1.84421983
78Prolonged neonatal jaundice (HP:0006579)1.84412845
79Cortical visual impairment (HP:0100704)1.84067481
80Episodic fever (HP:0001954)1.83975624
81Abnormality of the aortic arch (HP:0012303)1.83702976
82Stage 5 chronic kidney disease (HP:0003774)1.83420273
83Chronic hepatic failure (HP:0100626)1.82517780
84Clubbing of toes (HP:0100760)1.82346761
85Polygenic inheritance (HP:0010982)1.81946893
86Abnormality of dental color (HP:0011073)1.81150137
87Broad-based gait (HP:0002136)1.79691034
88Recurrent cutaneous fungal infections (HP:0011370)1.79628674
89Chronic mucocutaneous candidiasis (HP:0002728)1.79628674
90Septate vagina (HP:0001153)1.78742639
91Abnormal hair laboratory examination (HP:0003328)1.78435843
92Bell-shaped thorax (HP:0001591)1.78311467
93Inappropriate behavior (HP:0000719)1.77834230
94Abnormality of potassium homeostasis (HP:0011042)1.77289867
95Anterior segment dysgenesis (HP:0007700)1.76608342
96Protuberant abdomen (HP:0001538)1.76117273
97Congenital hepatic fibrosis (HP:0002612)1.75691476
98Type II lissencephaly (HP:0007260)1.75282913
99Optic neuritis (HP:0100653)1.73500402
100Retrobulbar optic neuritis (HP:0100654)1.73500402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.56806373
2MST1R3.88105816
3PLK43.17426787
4CDK123.04918079
5DDR23.04266768
6WNK12.69698105
7TESK12.25954226
8NEK22.25452355
9PRKD32.09784961
10MET2.06515760
11MAP3K112.04316969
12MAP3K131.98754601
13FLT31.89050628
14FRK1.87756623
15CAMK1G1.82393227
16SIK21.79399478
17MARK21.77974996
18MAPK151.69961753
19BLK1.56905046
20KIT1.51720498
21BRD41.47659415
22PTK2B1.41478883
23STK381.40802293
24PDPK11.24465984
25PIK3CG1.17851149
26RPS6KA21.16694072
27CASK1.13510913
28MARK11.12725996
29CAMK1D1.12588964
30PNCK1.11033286
31PDK11.10573614
32INSRR1.09411066
33ERN11.05783228
34CSF1R1.03960764
35NME11.02294663
36CLK11.00053941
37CDK70.95542339
38MTOR0.94716466
39TAOK30.94159207
40PINK10.93464604
41RPS6KA40.92734143
42CHUK0.92502287
43MAP3K70.92408240
44CDK30.92139949
45IRAK30.90927092
46ADRBK20.88278680
47TBK10.82184180
48EEF2K0.77017605
49DYRK1B0.76677697
50MAP3K80.75941160
51MAP3K140.75659331
52RPS6KC10.75284884
53RPS6KL10.75284884
54MAPK110.74523246
55CDK40.74523061
56SYK0.72047794
57PRKAA20.69852134
58PRKAA10.68435989
59RPS6KA60.67615403
60PRKG20.66692062
61PRKG10.64988845
62MAPK10.62220387
63IKBKB0.60542338
64BRAF0.58789485
65CDK20.56923858
66STK38L0.56459881
67RIPK40.56313200
68PRPF4B0.55166063
69UHMK10.54067683
70MAP4K10.53436206
71PHKG20.52892198
72PHKG10.52892198
73CAMKK20.51681683
74SGK10.51197988
75CCNB10.50936168
76KDR0.50914755
77CDK80.50025608
78JAK30.48667030
79ICK0.45621938
80RPS6KA10.45485329
81ZAP700.43842921
82ERBB20.43797049
83RIPK10.43525406
84PRKCZ0.42951438
85MAPK130.41182038
86PLK20.41098810
87MAP3K10.40930312
88GSK3B0.40782663
89TESK20.39945814
90BTK0.39937537
91CAMK10.39721361
92CDK10.38535533
93MAPK80.38303119
94LYN0.37840422
95MAP4K20.37609981
96IRAK20.37312112
97TEC0.37069476
98PRKCQ0.36884156
99MAP2K60.36353913
100MAPK100.36060115

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.23910825
2Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.91483747
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27949970
4Other glycan degradation_Homo sapiens_hsa005112.06799977
5Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.05236700
6Allograft rejection_Homo sapiens_hsa053301.91242037
7Graft-versus-host disease_Homo sapiens_hsa053321.79502145
8Type I diabetes mellitus_Homo sapiens_hsa049401.74710604
9Olfactory transduction_Homo sapiens_hsa047401.74122482
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72129413
11Leishmaniasis_Homo sapiens_hsa051401.71219555
12Type II diabetes mellitus_Homo sapiens_hsa049301.69538258
13Acute myeloid leukemia_Homo sapiens_hsa052211.67536464
14Autoimmune thyroid disease_Homo sapiens_hsa053201.62156081
15Dorso-ventral axis formation_Homo sapiens_hsa043201.56779141
16Fatty acid biosynthesis_Homo sapiens_hsa000611.56275218
17Asthma_Homo sapiens_hsa053101.51561215
18Influenza A_Homo sapiens_hsa051641.45653608
19mTOR signaling pathway_Homo sapiens_hsa041501.43813074
20Platelet activation_Homo sapiens_hsa046111.41641824
21Oocyte meiosis_Homo sapiens_hsa041141.40199609
22B cell receptor signaling pathway_Homo sapiens_hsa046621.38734601
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36483450
24Osteoclast differentiation_Homo sapiens_hsa043801.27456374
25Antigen processing and presentation_Homo sapiens_hsa046121.25048103
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24900160
27Hematopoietic cell lineage_Homo sapiens_hsa046401.21830201
28Salivary secretion_Homo sapiens_hsa049701.19116939
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17463873
30Viral myocarditis_Homo sapiens_hsa054161.16654874
31African trypanosomiasis_Homo sapiens_hsa051431.15913643
32Notch signaling pathway_Homo sapiens_hsa043301.14878229
33Tuberculosis_Homo sapiens_hsa051521.14358980
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.13484372
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09940283
36Selenocompound metabolism_Homo sapiens_hsa004501.09778395
37Herpes simplex infection_Homo sapiens_hsa051681.06915011
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.06719279
39Legionellosis_Homo sapiens_hsa051341.06643878
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05969095
41Staphylococcus aureus infection_Homo sapiens_hsa051501.04308576
42Butanoate metabolism_Homo sapiens_hsa006501.04268799
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.03620260
44Choline metabolism in cancer_Homo sapiens_hsa052311.02799404
45Regulation of autophagy_Homo sapiens_hsa041401.00959135
46Toxoplasmosis_Homo sapiens_hsa051451.00631133
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97571985
48Inositol phosphate metabolism_Homo sapiens_hsa005620.96334419
49Insulin resistance_Homo sapiens_hsa049310.95858265
50ABC transporters_Homo sapiens_hsa020100.95013115
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89803849
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89656538
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87682820
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86974954
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84671264
56Lysosome_Homo sapiens_hsa041420.82488919
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.80499623
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79926221
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.77905943
60Glycerolipid metabolism_Homo sapiens_hsa005610.77737165
61ErbB signaling pathway_Homo sapiens_hsa040120.77571414
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.71747165
63TNF signaling pathway_Homo sapiens_hsa046680.70831411
64Lysine degradation_Homo sapiens_hsa003100.67669018
65Non-small cell lung cancer_Homo sapiens_hsa052230.67589254
66Chronic myeloid leukemia_Homo sapiens_hsa052200.67476854
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66744395
68Amoebiasis_Homo sapiens_hsa051460.66608691
69Viral carcinogenesis_Homo sapiens_hsa052030.66431451
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65264474
71Pertussis_Homo sapiens_hsa051330.65225724
72Measles_Homo sapiens_hsa051620.64240402
73Hepatitis B_Homo sapiens_hsa051610.63323168
74Malaria_Homo sapiens_hsa051440.62522198
75Phototransduction_Homo sapiens_hsa047440.61782995
76Endocytosis_Homo sapiens_hsa041440.61314438
77VEGF signaling pathway_Homo sapiens_hsa043700.61073833
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58614088
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58007616
80Systemic lupus erythematosus_Homo sapiens_hsa053220.56146677
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.54109132
82Taste transduction_Homo sapiens_hsa047420.54065826
83Prolactin signaling pathway_Homo sapiens_hsa049170.52630883
84Fructose and mannose metabolism_Homo sapiens_hsa000510.52276130
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50644391
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.50310260
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49681055
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47032072
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.45805110
90HIF-1 signaling pathway_Homo sapiens_hsa040660.44925158
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44682803
92Oxytocin signaling pathway_Homo sapiens_hsa049210.44630610
93T cell receptor signaling pathway_Homo sapiens_hsa046600.42421132
94Estrogen signaling pathway_Homo sapiens_hsa049150.42418685
95Renal cell carcinoma_Homo sapiens_hsa052110.42084241
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41724010
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41136521
98Fanconi anemia pathway_Homo sapiens_hsa034600.40973581
99Insulin secretion_Homo sapiens_hsa049110.40564260
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38928457

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