ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.94740313
2	fucose catabolic process (GO:0019317)	5.70446400
3	L-fucose metabolic process (GO:0042354)	5.70446400
4	L-fucose catabolic process (GO:0042355)	5.70446400
5	behavioral response to nicotine (GO:0035095)	4.67150587
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.67082453
7	sperm motility (GO:0030317)	4.51588225
8	multicellular organism reproduction (GO:0032504)	4.43110254
9	piRNA metabolic process (GO:0034587)	4.39599999
10	regulation of female gonad development (GO:2000194)	4.30823946
11	cilium or flagellum-dependent cell motility (GO:0001539)	4.13407291
12	cellular ketone body metabolic process (GO:0046950)	3.84975477
13	epithelial cilium movement (GO:0003351)	3.83053850
14	tyrosine phosphorylation of STAT protein (GO:0007260)	3.73261377
15	RNA destabilization (GO:0050779)	3.66407482
16	detection of light stimulus involved in visual perception (GO:0050908)	3.56266038
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.56266038
18	DNA methylation involved in gamete generation (GO:0043046)	3.50852443
19	indolalkylamine catabolic process (GO:0046218)	3.44849672
20	tryptophan catabolic process (GO:0006569)	3.44849672
21	indole-containing compound catabolic process (GO:0042436)	3.44849672
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.42631069
23	NADH dehydrogenase complex assembly (GO:0010257)	3.42631069
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.42631069
25	indolalkylamine metabolic process (GO:0006586)	3.39042198
26	water-soluble vitamin biosynthetic process (GO:0042364)	3.36875169
27	macroautophagy (GO:0016236)	3.34889235
28	axoneme assembly (GO:0035082)	3.34531951
29	DNA deamination (GO:0045006)	3.34282306
30	ketone body metabolic process (GO:1902224)	3.33405441
31	single strand break repair (GO:0000012)	3.32113919
32	organic cation transport (GO:0015695)	3.29310057
33	male meiosis I (GO:0007141)	3.29153936
34	acrosome reaction (GO:0007340)	3.28722813
35	fucosylation (GO:0036065)	3.24773367
36	cilium movement (GO:0003341)	3.18954799
37	NAD biosynthetic process (GO:0009435)	3.18375606
38	protein complex biogenesis (GO:0070271)	3.15472543
39	male sex determination (GO:0030238)	3.13693602
40	cellular response to exogenous dsRNA (GO:0071360)	3.12239925
41	positive regulation of prostaglandin secretion (GO:0032308)	3.11602982
42	platelet dense granule organization (GO:0060155)	3.07502713
43	sulfur amino acid catabolic process (GO:0000098)	3.05307829
44	iron-sulfur cluster assembly (GO:0016226)	3.00372451
45	metallo-sulfur cluster assembly (GO:0031163)	3.00372451
46	rhodopsin mediated signaling pathway (GO:0016056)	2.97493549
47	reproduction (GO:0000003)	2.94912190
48	preassembly of GPI anchor in ER membrane (GO:0016254)	2.94586549
49	phosphatidylglycerol biosynthetic process (GO:0006655)	2.92666427
50	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91633553
51	amine catabolic process (GO:0009310)	2.86327537
52	cellular biogenic amine catabolic process (GO:0042402)	2.86327537
53	regulation of male gonad development (GO:2000018)	2.82006806
54	protein polyglutamylation (GO:0018095)	2.80411336
55	ovulation cycle (GO:0042698)	2.78581394
56	regulation of triglyceride biosynthetic process (GO:0010866)	2.75248683
57	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.74599033
58	nucleoside diphosphate catabolic process (GO:0009134)	2.73877423
59	sperm-egg recognition (GO:0035036)	2.73423019
60	seminiferous tubule development (GO:0072520)	2.72507581
61	tryptophan metabolic process (GO:0006568)	2.72445358
62	kynurenine metabolic process (GO:0070189)	2.71661204
63	regulation of transmission of nerve impulse (GO:0051969)	2.70463601
64	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.69459811
65	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.67658953
66	positive regulation of fatty acid transport (GO:2000193)	2.67151704
67	cilium organization (GO:0044782)	2.66426469
68	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.64454606
69	adenosine metabolic process (GO:0046085)	2.63700763
70	negative regulation of telomere maintenance (GO:0032205)	2.62975031
71	negative regulation of mast cell activation (GO:0033004)	2.62720203
72	C4-dicarboxylate transport (GO:0015740)	2.62559831
73	cellular response to interferon-beta (GO:0035458)	2.60592651
74	fucose metabolic process (GO:0006004)	2.60435150
75	tRNA methylation (GO:0030488)	2.59869801
76	neuronal action potential (GO:0019228)	2.58043350
77	tRNA modification (GO:0006400)	2.57019376
78	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.57000490
79	cilium assembly (GO:0042384)	2.56246426
80	male meiosis (GO:0007140)	2.54942285
81	reciprocal DNA recombination (GO:0035825)	2.54586900
82	reciprocal meiotic recombination (GO:0007131)	2.54586900
83	intraciliary transport (GO:0042073)	2.53207399
84	cell-cell recognition (GO:0009988)	2.52763867
85	cilium morphogenesis (GO:0060271)	2.51375643
86	sex determination (GO:0007530)	2.50850534
87	protein K6-linked ubiquitination (GO:0085020)	2.50120199
88	cellular biogenic amine biosynthetic process (GO:0042401)	2.49238022
89	axonemal dynein complex assembly (GO:0070286)	2.48421013
90	signal peptide processing (GO:0006465)	2.46977128
91	amine biosynthetic process (GO:0009309)	2.46785806
92	indole-containing compound metabolic process (GO:0042430)	2.46343723
93	mannosylation (GO:0097502)	2.45487652
94	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.45080566
95	behavioral response to ethanol (GO:0048149)	2.44835352
96	fusion of sperm to egg plasma membrane (GO:0007342)	2.44765286
97	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.44213710
98	positive regulation of growth hormone secretion (GO:0060124)	2.43777153
99	single fertilization (GO:0007338)	2.40854686
100	photoreceptor cell maintenance (GO:0045494)	2.39312857

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.65318767
2	IGF1R_20145208_ChIP-Seq_DFB_Human	2.93774391
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.58608073
4	VDR_22108803_ChIP-Seq_LS180_Human	2.53996014
5	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.45818892
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.32416355
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23461386
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15040819
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11442623
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.08917268
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06878988
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.03027181
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98071648
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81572549
15	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.80891187
16	TP53_22573176_ChIP-Seq_HFKS_Human	1.77262128
17	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73889265
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.72485503
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.64057672
20	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.63090413
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62181999
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61693197
23	AR_20517297_ChIP-Seq_VCAP_Human	1.60414574
24	MYC_19829295_ChIP-Seq_ESCs_Human	1.59695279
25	NANOG_19829295_ChIP-Seq_ESCs_Human	1.58949650
26	SOX2_19829295_ChIP-Seq_ESCs_Human	1.58949650
27	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.57386395
28	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.56606869
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.56460701
30	FUS_26573619_Chip-Seq_HEK293_Human	1.54956860
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.52505525
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52505525
33	TAF2_19829295_ChIP-Seq_ESCs_Human	1.51927035
34	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.51459889
35	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.51427533
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50519206
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48927335
38	P300_19829295_ChIP-Seq_ESCs_Human	1.46903243
39	ERA_21632823_ChIP-Seq_H3396_Human	1.46820049
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.45543800
41	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.45348299
42	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44070005
43	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.39159733
44	OCT4_20526341_ChIP-Seq_ESCs_Human	1.39144221
45	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.38424963
46	NCOR_22424771_ChIP-Seq_293T_Human	1.38292076
47	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.34471555
48	NANOG_20526341_ChIP-Seq_ESCs_Human	1.33556118
49	HOXB7_26014856_ChIP-Seq_BT474_Human	1.32469823
50	RAC3_21632823_ChIP-Seq_H3396_Human	1.27167070
51	STAT3_23295773_ChIP-Seq_U87_Human	1.26689981
52	GATA3_26560356_Chip-Seq_TH2_Human	1.26245211
53	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.24765663
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24566488
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23880680
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22793961
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21305404
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21305404
59	VDR_23849224_ChIP-Seq_CD4+_Human	1.19518132
60	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.19110026
61	EWS_26573619_Chip-Seq_HEK293_Human	1.19096895
62	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.19089563
63	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.18960132
64	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.17249024
65	BCAT_22108803_ChIP-Seq_LS180_Human	1.15677481
66	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14951458
67	E2F1_20622854_ChIP-Seq_HELA_Human	1.14832997
68	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.14569833
69	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.14297137
70	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14044800
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.13459626
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13197385
73	P53_21459846_ChIP-Seq_SAOS-2_Human	1.11644874
74	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11560183
75	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11560183
76	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.11502801
77	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09602088
78	P300_27268052_Chip-Seq_Bcells_Human	1.09079447
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08846923
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08759548
81	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08611361
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07472193
83	BCL6_27268052_Chip-Seq_Bcells_Human	1.06926002
84	CEBPB_22108803_ChIP-Seq_LS180_Human	1.06628498
85	AR_25329375_ChIP-Seq_VCAP_Human	1.06258203
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06145683
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06045937
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04908665
89	TCF4_23295773_ChIP-Seq_U87_Human	1.04252541
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02409236
91	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.01919787
92	AR_21572438_ChIP-Seq_LNCaP_Human	1.01784500
93	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00000670
94	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.98664196
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97148166
96	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.95985423
97	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95275078
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93761630
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93429313
100	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.92964634

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.29777667
2	MP0005646_abnormal_pituitary_gland	3.21783185
3	MP0008875_abnormal_xenobiotic_pharmacok	3.00365971
4	MP0008877_abnormal_DNA_methylation	2.91295952
5	MP0002102_abnormal_ear_morphology	2.59381570
6	MP0003195_calcinosis	2.58615928
7	MP0005645_abnormal_hypothalamus_physiol	2.49341327
8	MP0005551_abnormal_eye_electrophysiolog	2.44985596
9	MP0001485_abnormal_pinna_reflex	2.36367851
10	MP0003283_abnormal_digestive_organ	2.25938011
11	MP0002876_abnormal_thyroid_physiology	2.23680398
12	MP0002638_abnormal_pupillary_reflex	2.22247304
13	MP0003787_abnormal_imprinting	2.14230244
14	MP0005670_abnormal_white_adipose	2.05160777
15	MP0006292_abnormal_olfactory_placode	2.01022262
16	MP0004133_heterotaxia	1.94706976
17	MP0001986_abnormal_taste_sensitivity	1.94138093
18	MP0005377_hearing/vestibular/ear_phenot	1.87512465
19	MP0003878_abnormal_ear_physiology	1.87512465
20	MP0004043_abnormal_pH_regulation	1.83464872
21	MP0003698_abnormal_male_reproductive	1.68442325
22	MP0002234_abnormal_pharynx_morphology	1.66358140
23	MP0001929_abnormal_gametogenesis	1.60302355
24	MP0005187_abnormal_penis_morphology	1.58681667
25	MP0001764_abnormal_homeostasis	1.55201733
26	MP0006276_abnormal_autonomic_nervous	1.54590985
27	MP0001501_abnormal_sleep_pattern	1.52408358
28	MP0003646_muscle_fatigue	1.51451174
29	MP0005379_endocrine/exocrine_gland_phen	1.50281891
30	MP0001968_abnormal_touch/_nociception	1.46280708
31	MP0009046_muscle_twitch	1.43884485
32	MP0000613_abnormal_salivary_gland	1.40125186
33	MP0000427_abnormal_hair_cycle	1.37703999
34	MP0004885_abnormal_endolymph	1.37701126
35	MP0001984_abnormal_olfaction	1.37378212
36	MP0004742_abnormal_vestibular_system	1.35847055
37	MP0005253_abnormal_eye_physiology	1.32214704
38	MP0008872_abnormal_physiological_respon	1.26949080
39	MP0008961_abnormal_basal_metabolism	1.26831031
40	MP0002837_dystrophic_cardiac_calcinosis	1.26019191
41	MP0002138_abnormal_hepatobiliary_system	1.23971481
42	MP0002909_abnormal_adrenal_gland	1.23147228
43	MP0008995_early_reproductive_senescence	1.21066359
44	MP0000383_abnormal_hair_follicle	1.20438028
45	MP0000631_abnormal_neuroendocrine_gland	1.18843131
46	MP0009745_abnormal_behavioral_response	1.17931966
47	MP0000372_irregular_coat_pigmentation	1.17255331
48	MP0001486_abnormal_startle_reflex	1.16894113
49	MP0005332_abnormal_amino_acid	1.16889948
50	MP0010329_abnormal_lipoprotein_level	1.10738797
51	MP0005671_abnormal_response_to	1.10231275
52	MP0006072_abnormal_retinal_apoptosis	1.09741731
53	MP0002139_abnormal_hepatobiliary_system	1.09633625
54	MP0002210_abnormal_sex_determination	1.08856564
55	MP0004019_abnormal_vitamin_homeostasis	1.07059920
56	MP0003011_delayed_dark_adaptation	1.06142770
57	MP0001963_abnormal_hearing_physiology	1.03620920
58	MP0000026_abnormal_inner_ear	1.02512959
59	MP0003879_abnormal_hair_cell	0.99729481
60	MP0001765_abnormal_ion_homeostasis	0.99437605
61	MP0005167_abnormal_blood-brain_barrier	0.98066676
62	MP0002736_abnormal_nociception_after	0.96582256
63	MP0005365_abnormal_bile_salt	0.95835399
64	MP0000653_abnormal_sex_gland	0.93921494
65	MP0003122_maternal_imprinting	0.92958635
66	MP0002693_abnormal_pancreas_physiology	0.91403359
67	MP0002254_reproductive_system_inflammat	0.91287236
68	MP0001502_abnormal_circadian_rhythm	0.90963815
69	MP0003315_abnormal_perineum_morphology	0.89908752
70	MP0004145_abnormal_muscle_electrophysio	0.88995557
71	MP0006036_abnormal_mitochondrial_physio	0.88319740
72	MP0002735_abnormal_chemical_nociception	0.87161656
73	MP0000230_abnormal_systemic_arterial	0.86857006
74	MP0002160_abnormal_reproductive_system	0.85720880
75	MP0002272_abnormal_nervous_system	0.85468413
76	MP0002653_abnormal_ependyma_morphology	0.84417438
77	MP0002733_abnormal_thermal_nociception	0.84257522
78	MP0003137_abnormal_impulse_conducting	0.83468743
79	MP0001145_abnormal_male_reproductive	0.83194277
80	MP0002572_abnormal_emotion/affect_behav	0.83105094
81	MP0003718_maternal_effect	0.82723020
82	MP0005075_abnormal_melanosome_morpholog	0.82106451
83	MP0005389_reproductive_system_phenotype	0.81970232
84	MP0002229_neurodegeneration	0.81211083
85	MP0000685_abnormal_immune_system	0.80835680
86	MP0001970_abnormal_pain_threshold	0.80832807
87	MP0008058_abnormal_DNA_repair	0.80183474
88	MP0005535_abnormal_body_temperature	0.80069979
89	MP0005647_abnormal_sex_gland	0.79726560
90	MP0005360_urolithiasis	0.79093609
91	MP0002095_abnormal_skin_pigmentation	0.78861843
92	MP0002928_abnormal_bile_duct	0.75703611
93	MP0002163_abnormal_gland_morphology	0.74468861
94	MP0005195_abnormal_posterior_eye	0.73043641
95	MP0004147_increased_porphyrin_level	0.72452182
96	MP0001119_abnormal_female_reproductive	0.71969887
97	MP0001835_abnormal_antigen_presentation	0.71956166
98	MP0009785_altered_susceptibility_to	0.70350960
99	MP0004215_abnormal_myocardial_fiber	0.69794398
100	MP0002161_abnormal_fertility/fecundity	0.68635069

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.72341054
2	True hermaphroditism (HP:0010459)	4.52648727
3	Type II lissencephaly (HP:0007260)	4.24262892
4	Pancreatic fibrosis (HP:0100732)	3.97242248
5	Nephronophthisis (HP:0000090)	3.94473462
6	Abnormality of midbrain morphology (HP:0002418)	3.91548157
7	Molar tooth sign on MRI (HP:0002419)	3.91548157
8	Attenuation of retinal blood vessels (HP:0007843)	3.55686409
9	Congenital stationary night blindness (HP:0007642)	3.55535350
10	Abnormality of the renal cortex (HP:0011035)	3.47386987
11	Cystic liver disease (HP:0006706)	3.41980923
12	Chronic hepatic failure (HP:0100626)	3.36029208
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.32443265
14	Abnormality of the renal medulla (HP:0100957)	3.22742134
15	Tubular atrophy (HP:0000092)	3.20966102
16	Retinal dysplasia (HP:0007973)	3.17920424
17	Polydipsia (HP:0001959)	3.07967036
18	Abnormal drinking behavior (HP:0030082)	3.07967036
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.90905194
20	Occipital encephalocele (HP:0002085)	2.86400774
21	3-Methylglutaconic aciduria (HP:0003535)	2.76575097
22	Renal cortical cysts (HP:0000803)	2.76439414
23	Abnormal biliary tract physiology (HP:0012439)	2.62894912
24	Bile duct proliferation (HP:0001408)	2.62894912
25	Medial flaring of the eyebrow (HP:0010747)	2.62604485
26	Abolished electroretinogram (ERG) (HP:0000550)	2.62047836
27	Concave nail (HP:0001598)	2.56609338
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.54507655
29	Sclerocornea (HP:0000647)	2.52924439
30	Cerebellar dysplasia (HP:0007033)	2.50843359
31	Birth length less than 3rd percentile (HP:0003561)	2.48947938
32	Anencephaly (HP:0002323)	2.47547475
33	Severe visual impairment (HP:0001141)	2.43443337
34	Absent/shortened dynein arms (HP:0200106)	2.39670825
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39670825
36	Progressive cerebellar ataxia (HP:0002073)	2.39293213
37	Lissencephaly (HP:0001339)	2.38807530
38	Hyperglycinuria (HP:0003108)	2.33772479
39	Congenital hepatic fibrosis (HP:0002612)	2.32578047
40	Recurrent corneal erosions (HP:0000495)	2.32457602
41	Abnormal number of erythroid precursors (HP:0012131)	2.30586571
42	Polyuria (HP:0000103)	2.29963917
43	Furrowed tongue (HP:0000221)	2.27746494
44	Male pseudohermaphroditism (HP:0000037)	2.26987609
45	Severe muscular hypotonia (HP:0006829)	2.22521197
46	Severe combined immunodeficiency (HP:0004430)	2.21293458
47	Ketoacidosis (HP:0001993)	2.20546999
48	Abnormality of alanine metabolism (HP:0010916)	2.20257103
49	Hyperalaninemia (HP:0003348)	2.20257103
50	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.20257103
51	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.18892647
52	Genetic anticipation (HP:0003743)	2.18380797
53	Arthropathy (HP:0003040)	2.18016717
54	Postaxial foot polydactyly (HP:0001830)	2.17969219
55	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.17252742
56	Asplenia (HP:0001746)	2.14149493
57	Abnormal urine output (HP:0012590)	2.13177559
58	Congenital primary aphakia (HP:0007707)	2.09784922
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.08978813
60	Hyperglycinemia (HP:0002154)	2.08801916
61	Ketosis (HP:0001946)	2.04859650
62	Nephrogenic diabetes insipidus (HP:0009806)	2.04539966
63	Gait imbalance (HP:0002141)	2.04152656
64	Optic disc pallor (HP:0000543)	2.02297814
65	Decreased circulating renin level (HP:0003351)	1.99981623
66	Keratoconus (HP:0000563)	1.99046641
67	Increased corneal curvature (HP:0100692)	1.99046641
68	Abnormality of glycine metabolism (HP:0010895)	1.94997532
69	Abnormality of serine family amino acid metabolism (HP:0010894)	1.94997532
70	Recurrent cutaneous fungal infections (HP:0011370)	1.93804475
71	Chronic mucocutaneous candidiasis (HP:0002728)	1.93804475
72	Bony spicule pigmentary retinopathy (HP:0007737)	1.93188656
73	Abnormality of renal excretion (HP:0011036)	1.91136120
74	Acute encephalopathy (HP:0006846)	1.90119495
75	Hemiparesis (HP:0001269)	1.90103562
76	Inability to walk (HP:0002540)	1.89054084
77	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88678003
78	Abnormal respiratory epithelium morphology (HP:0012253)	1.88678003
79	Tachypnea (HP:0002789)	1.87977177
80	Abnormal ciliary motility (HP:0012262)	1.87650293
81	Mitochondrial inheritance (HP:0001427)	1.87497677
82	Abnormality of B cell number (HP:0010975)	1.87346338
83	Abnormal albumin level (HP:0012116)	1.87337083
84	Hypoalbuminemia (HP:0003073)	1.87337083
85	Methylmalonic aciduria (HP:0012120)	1.86895382
86	Retinal atrophy (HP:0001105)	1.86001297
87	Stage 5 chronic kidney disease (HP:0003774)	1.84813845
88	Tubulointerstitial nephritis (HP:0001970)	1.83822647
89	Methylmalonic acidemia (HP:0002912)	1.82953098
90	Tinnitus (HP:0000360)	1.81947370
91	Pendular nystagmus (HP:0012043)	1.80975789
92	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.76846501
93	Episodic fever (HP:0001954)	1.73755418
94	Gaze-evoked nystagmus (HP:0000640)	1.73578438
95	Muscle hypertrophy of the lower extremities (HP:0008968)	1.73020852
96	Abnormality of cells of the erythroid lineage (HP:0012130)	1.71492935
97	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.71421941
98	Calf muscle hypertrophy (HP:0008981)	1.68636783
99	Holoprosencephaly (HP:0001360)	1.68632575
100	Preaxial hand polydactyly (HP:0001177)	1.67250627

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	5.13925793
2	FRK	4.98043915
3	ADRBK2	3.18861218
4	PINK1	2.89099463
5	CDK19	2.54865717
6	BMPR1B	2.35438075
7	WNK4	2.20108665
8	KIT	1.92963922
9	TXK	1.90634342
10	GRK1	1.87478816
11	KDR	1.86068229
12	SIK2	1.79624495
13	ACVR1B	1.69928558
14	TEC	1.68069798
15	IKBKE	1.65996039
16	WNK3	1.64198079
17	PASK	1.63377593
18	TAOK3	1.62930055
19	PLK4	1.56450455
20	ZAK	1.54612001
21	MAP3K4	1.52743842
22	MAPKAPK3	1.49455209
23	STK39	1.46559484
24	ITK	1.44052421
25	BCKDK	1.39544250
26	FLT3	1.31540702
27	IKBKB	1.31268804
28	TLK1	1.24423285
29	PRKCQ	1.19327447
30	MAP4K2	1.14694950
31	CAMK1	1.14600983
32	NUAK1	1.07750430
33	SYK	1.05713871
34	CSNK1G3	1.03429752
35	STK16	1.03015619
36	PLK2	0.99172734
37	OXSR1	0.98468936
38	CSNK1G2	0.97792782
39	MAPK13	0.95659299
40	DAPK2	0.94247452
41	TBK1	0.92294641
42	ADRBK1	0.90046561
43	PTK2B	0.86613974
44	PRKAA2	0.84738997
45	SIK3	0.83222581
46	MAP4K1	0.83014153
47	DYRK3	0.78639208
48	CAMK1G	0.77497924
49	RPS6KA5	0.74334417
50	PTK6	0.74140473
51	MAP2K6	0.73762810
52	DYRK2	0.73584653
53	CAMK1D	0.72114718
54	CSNK1G1	0.70321519
55	CSF1R	0.70027232
56	CSNK1A1L	0.69176098
57	TESK2	0.68257180
58	MARK3	0.65109270
59	MAP3K7	0.64856089
60	PRKAA1	0.64848711
61	LYN	0.63830913
62	PAK3	0.62872841
63	PKN1	0.61268063
64	TIE1	0.60763184
65	PRKCE	0.58797709
66	IRAK1	0.58331547
67	BLK	0.56913261
68	BTK	0.56800296
69	LCK	0.52452362
70	MAPK15	0.52413400
71	PRKACA	0.50988000
72	MUSK	0.49904294
73	CAMK2D	0.49358882
74	PRKCG	0.48194473
75	IRAK4	0.48030195
76	ATR	0.47462969
77	PRKCH	0.46586309
78	PHKG2	0.46287385
79	PHKG1	0.46287385
80	TYRO3	0.45441349
81	TGFBR1	0.45050215
82	CSNK1A1	0.44685702
83	PRKCA	0.44482753
84	CSNK1D	0.44220556
85	CAMK2A	0.43850963
86	VRK1	0.43538830
87	JAK3	0.43272679
88	PNCK	0.43140651
89	PRKD3	0.42963421
90	STK38L	0.41613797
91	NEK2	0.41061938
92	PRKG1	0.40468687
93	OBSCN	0.40250924
94	LIMK1	0.40098359
95	AKT3	0.37832779
96	NME1	0.37499865
97	CAMK4	0.37337112
98	CHUK	0.35153040
99	PRKD2	0.35146270
100	CASK	0.34728684

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.71451527
2	Phototransduction_Homo sapiens_hsa04744	2.88204737
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.73138774
4	Butanoate metabolism_Homo sapiens_hsa00650	2.56437971
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.52692444
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.52124916
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.33691275
8	Caffeine metabolism_Homo sapiens_hsa00232	2.30383422
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.29731995
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.25441861
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24914623
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.19823667
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.16992658
14	Olfactory transduction_Homo sapiens_hsa04740	2.07458297
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.99060330
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.89999852
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.85790256
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.71178337
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.64076856
20	ABC transporters_Homo sapiens_hsa02010	1.58894560
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57981595
22	Homologous recombination_Homo sapiens_hsa03440	1.48522503
23	Peroxisome_Homo sapiens_hsa04146	1.47867297
24	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.44622906
25	Basal transcription factors_Homo sapiens_hsa03022	1.40423474
26	One carbon pool by folate_Homo sapiens_hsa00670	1.38704152
27	Propanoate metabolism_Homo sapiens_hsa00640	1.37954586
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.30267293
29	RNA polymerase_Homo sapiens_hsa03020	1.30241310
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24124258
31	Glycerolipid metabolism_Homo sapiens_hsa00561	1.23253698
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15981353
33	Oxidative phosphorylation_Homo sapiens_hsa00190	1.12284189
34	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.11541991
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09946962
36	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.09350432
37	Insulin secretion_Homo sapiens_hsa04911	1.08933753
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.08880555
39	Histidine metabolism_Homo sapiens_hsa00340	1.07760945
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03041318
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02846085
42	Type I diabetes mellitus_Homo sapiens_hsa04940	1.02817606
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01636436
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99624938
45	Protein export_Homo sapiens_hsa03060	0.99017177
46	Taste transduction_Homo sapiens_hsa04742	0.97762305
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94692088
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94168345
49	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.93714797
50	Purine metabolism_Homo sapiens_hsa00230	0.93701733
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.93389301
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.93052890
53	RNA degradation_Homo sapiens_hsa03018	0.92626096
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90130648
55	Retinol metabolism_Homo sapiens_hsa00830	0.85356447
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83204369
57	Regulation of autophagy_Homo sapiens_hsa04140	0.81812018
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81314072
59	Morphine addiction_Homo sapiens_hsa05032	0.80693644
60	Parkinsons disease_Homo sapiens_hsa05012	0.79880631
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78698036
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76602738
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68712000
64	Metabolic pathways_Homo sapiens_hsa01100	0.66766080
65	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.65801098
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.63943785
67	Serotonergic synapse_Homo sapiens_hsa04726	0.63682406
68	Huntingtons disease_Homo sapiens_hsa05016	0.63414827
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.61035652
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59170859
71	Antigen processing and presentation_Homo sapiens_hsa04612	0.58247471
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.57723933
73	Bile secretion_Homo sapiens_hsa04976	0.56136006
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.56105057
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.55171134
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55072739
77	Ribosome_Homo sapiens_hsa03010	0.52390410
78	Salivary secretion_Homo sapiens_hsa04970	0.52252333
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.51723213
80	Fatty acid degradation_Homo sapiens_hsa00071	0.51539269
81	Mineral absorption_Homo sapiens_hsa04978	0.50589365
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.49335422
83	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.44789639
84	Nicotine addiction_Homo sapiens_hsa05033	0.43341875
85	Allograft rejection_Homo sapiens_hsa05330	0.42645160
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.37699524
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37588321
88	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.36959381
89	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36890070
90	Pancreatic secretion_Homo sapiens_hsa04972	0.36474637
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36023069
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35748814
93	Asthma_Homo sapiens_hsa05310	0.34658290
94	GABAergic synapse_Homo sapiens_hsa04727	0.34339007
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34326646
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33902666
97	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.33683386
98	Circadian entrainment_Homo sapiens_hsa04713	0.32734633
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.29406154
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.28579835

GOLGA8IP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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