Rank | Gene Set | Z-score |
---|---|---|
1 | fusion of sperm to egg plasma membrane (GO:0007342) | 9.86454945 |
2 | sperm capacitation (GO:0048240) | 9.79425314 |
3 | chromosome condensation (GO:0030261) | 9.27633272 |
4 | response to pheromone (GO:0019236) | 9.23432144 |
5 | DNA packaging (GO:0006323) | 8.91845179 |
6 | single strand break repair (GO:0000012) | 8.32585979 |
7 | spermatid nucleus differentiation (GO:0007289) | 8.01539485 |
8 | plasma membrane fusion (GO:0045026) | 7.40434600 |
9 | sperm-egg recognition (GO:0035036) | 7.33753519 |
10 | multicellular organism reproduction (GO:0032504) | 7.18472454 |
11 | rRNA methylation (GO:0031167) | 7.11949266 |
12 | microtubule depolymerization (GO:0007019) | 7.07067846 |
13 | spermatid development (GO:0007286) | 7.05258333 |
14 | reproduction (GO:0000003) | 6.75237410 |
15 | sexual reproduction (GO:0019953) | 6.55714880 |
16 | protein targeting to Golgi (GO:0000042) | 6.52257974 |
17 | binding of sperm to zona pellucida (GO:0007339) | 6.36879458 |
18 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 6.33078217 |
19 | establishment of protein localization to Golgi (GO:0072600) | 6.32920518 |
20 | negative regulation of inclusion body assembly (GO:0090084) | 6.32476312 |
21 | cell-cell recognition (GO:0009988) | 6.22780298 |
22 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 6.21204991 |
23 | rRNA modification (GO:0000154) | 5.90438482 |
24 | microtubule polymerization or depolymerization (GO:0031109) | 5.81836166 |
25 | protein polyglutamylation (GO:0018095) | 5.68322556 |
26 | spermatogenesis (GO:0007283) | 5.52264316 |
27 | male gamete generation (GO:0048232) | 5.50518266 |
28 | calcium ion-dependent exocytosis (GO:0017156) | 5.46827601 |
29 | axonemal dynein complex assembly (GO:0070286) | 5.38346001 |
30 | positive regulation of Rab GTPase activity (GO:0032851) | 5.31571222 |
31 | regulation of Rab GTPase activity (GO:0032313) | 5.31571222 |
32 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 5.24433793 |
33 | centriole replication (GO:0007099) | 5.11610644 |
34 | chromatin silencing (GO:0006342) | 5.08271263 |
35 | gamete generation (GO:0007276) | 5.02879801 |
36 | microtubule severing (GO:0051013) | 4.99655335 |
37 | single fertilization (GO:0007338) | 4.96091137 |
38 | cellular ketone body metabolic process (GO:0046950) | 4.95728473 |
39 | cell wall macromolecule catabolic process (GO:0016998) | 4.95088439 |
40 | cilium or flagellum-dependent cell motility (GO:0001539) | 4.89208195 |
41 | phosphatidylethanolamine metabolic process (GO:0046337) | 4.75251590 |
42 | motile cilium assembly (GO:0044458) | 4.65024338 |
43 | protein localization to Golgi apparatus (GO:0034067) | 4.63426294 |
44 | cell wall macromolecule metabolic process (GO:0044036) | 4.59842677 |
45 | centriole assembly (GO:0098534) | 4.42062841 |
46 | RNA destabilization (GO:0050779) | 4.37950870 |
47 | ketone body metabolic process (GO:1902224) | 4.30465574 |
48 | regulation of inclusion body assembly (GO:0090083) | 4.21535912 |
49 | nucleus organization (GO:0006997) | 4.15583480 |
50 | fertilization (GO:0009566) | 4.07207855 |
51 | glycerol ether metabolic process (GO:0006662) | 4.05539259 |
52 | regulation of cilium movement (GO:0003352) | 4.03404130 |
53 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 4.03349696 |
54 | multicellular organismal reproductive process (GO:0048609) | 4.01787643 |
55 | germ cell development (GO:0007281) | 4.00944230 |
56 | seminiferous tubule development (GO:0072520) | 3.94307421 |
57 | regulation of centriole replication (GO:0046599) | 3.91885258 |
58 | regulation of ARF GTPase activity (GO:0032312) | 3.91458772 |
59 | negative regulation of gene expression, epigenetic (GO:0045814) | 3.85335784 |
60 | ether metabolic process (GO:0018904) | 3.72077438 |
61 | histone H3-K9 demethylation (GO:0033169) | 3.69676752 |
62 | negative regulation of Rho protein signal transduction (GO:0035024) | 3.54372252 |
63 | negative regulation of histone methylation (GO:0031061) | 3.47523344 |
64 | DNA conformation change (GO:0071103) | 3.45339071 |
65 | negative regulation of granulocyte differentiation (GO:0030853) | 3.40417370 |
66 | protein-DNA complex disassembly (GO:0032986) | 3.34589075 |
67 | nucleosome disassembly (GO:0006337) | 3.34589075 |
68 | epithelial cilium movement (GO:0003351) | 3.34062799 |
69 | regulation of transcription involved in cell fate commitment (GO:0060850) | 3.33899568 |
70 | coenzyme catabolic process (GO:0009109) | 3.28184266 |
71 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 3.25273522 |
72 | regulation of histone H3-K27 methylation (GO:0061085) | 3.17826044 |
73 | histone H3-K36 demethylation (GO:0070544) | 3.17731417 |
74 | cilium movement (GO:0003341) | 3.10175379 |
75 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.09920878 |
76 | microtubule nucleation (GO:0007020) | 3.08050937 |
77 | homeostasis of number of cells within a tissue (GO:0048873) | 2.97065073 |
78 | peptidyl-threonine dephosphorylation (GO:0035970) | 2.92749408 |
79 | cranial nerve morphogenesis (GO:0021602) | 2.85930878 |
80 | detection of chemical stimulus involved in sensory perception of smell (GO:0050911) | 2.83621457 |
81 | cell recognition (GO:0008037) | 2.82875479 |
82 | gene silencing (GO:0016458) | 2.82545635 |
83 | NAD biosynthetic process (GO:0009435) | 2.82234766 |
84 | protein depolymerization (GO:0051261) | 2.81954811 |
85 | polyamine biosynthetic process (GO:0006596) | 2.79730367 |
86 | histone H4 deacetylation (GO:0070933) | 2.79688778 |
87 | cerebral cortex neuron differentiation (GO:0021895) | 2.79433049 |
88 | DNA methylation involved in gamete generation (GO:0043046) | 2.77484654 |
89 | membrane protein intracellular domain proteolysis (GO:0031293) | 2.77123274 |
90 | piRNA metabolic process (GO:0034587) | 2.74833702 |
91 | glomerular visceral epithelial cell development (GO:0072015) | 2.73699499 |
92 | multicellular organismal movement (GO:0050879) | 2.72936619 |
93 | musculoskeletal movement (GO:0050881) | 2.72936619 |
94 | peptidyl-proline hydroxylation (GO:0019511) | 2.71623199 |
95 | multicellular organismal development (GO:0007275) | 2.71182169 |
96 | cell differentiation involved in metanephros development (GO:0072202) | 2.70567458 |
97 | peptide catabolic process (GO:0043171) | 2.68392108 |
98 | regulation of microtubule-based movement (GO:0060632) | 2.67675319 |
99 | sperm motility (GO:0030317) | 10.7974206 |
100 | acrosome reaction (GO:0007340) | 10.7371830 |
Rank | Gene Set | Z-score |
---|---|---|
1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.18830127 |
2 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 3.33904416 |
3 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.28648516 |
4 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 2.58774832 |
5 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 2.42815115 |
6 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.25481385 |
7 | BCL6_27268052_Chip-Seq_Bcells_Human | 2.21259958 |
8 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.10502755 |
9 | ERA_21632823_ChIP-Seq_H3396_Human | 2.08422385 |
10 | CBP_20019798_ChIP-Seq_JUKART_Human | 2.07860392 |
11 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 2.07860392 |
12 | RAC3_21632823_ChIP-Seq_H3396_Human | 2.07371684 |
13 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 2.07026755 |
14 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.05178442 |
15 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 2.05178442 |
16 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 2.01391590 |
17 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.99162783 |
18 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.98600086 |
19 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.96737176 |
20 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.96159639 |
21 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.95386669 |
22 | P68_20966046_ChIP-Seq_HELA_Human | 1.92726118 |
23 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.90416097 |
24 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.85994074 |
25 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.82714952 |
26 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.78467045 |
27 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.73345306 |
28 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.66917366 |
29 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.64912949 |
30 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.59397135 |
31 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.58974269 |
32 | P300_27268052_Chip-Seq_Bcells_Human | 1.58056941 |
33 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.57432340 |
34 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.55930260 |
35 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.55735108 |
36 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.55428378 |
37 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.55113883 |
38 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.55099757 |
39 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.54049532 |
40 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.51499754 |
41 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.49412918 |
42 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.48215584 |
43 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.46397092 |
44 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.42465988 |
45 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.41488824 |
46 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.39094351 |
47 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.38847123 |
48 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.37912631 |
49 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.36779291 |
50 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.34476771 |
51 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.33910149 |
52 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.33649810 |
53 | FUS_26573619_Chip-Seq_HEK293_Human | 1.30477547 |
54 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.30311278 |
55 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.28580019 |
56 | SPI1_23127762_ChIP-Seq_K562_Human | 1.27365230 |
57 | SA1_27219007_Chip-Seq_Bcells_Human | 1.26795820 |
58 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 1.26097562 |
59 | GATA1_19941826_ChIP-Seq_K562_Human | 1.26042453 |
60 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.25963937 |
61 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.25918564 |
62 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.24936460 |
63 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.23626812 |
64 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.22799427 |
65 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.22327105 |
66 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.20562486 |
67 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 1.18619495 |
68 | RBPJ_21746931_ChIP-Seq_IB4_Human | 1.18443861 |
69 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.18268246 |
70 | MYB_26560356_Chip-Seq_TH2_Human | 1.17935567 |
71 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.17004202 |
72 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.16378005 |
73 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.15994626 |
74 | NFYB_21822215_ChIP-Seq_K562_Human | 1.15573693 |
75 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.13986434 |
76 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.13346181 |
77 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.12823255 |
78 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.10318590 |
79 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.09874091 |
80 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.07711515 |
81 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 1.07249779 |
82 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.06430060 |
83 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.05725530 |
84 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.05675060 |
85 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.05545502 |
86 | TBL1_22424771_ChIP-Seq_293T_Human | 1.04257930 |
87 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.04177185 |
88 | E2F1_17053090_ChIP-ChIP_MCF-7_Human | 1.03535349 |
89 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.01944497 |
90 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.01300666 |
91 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.00472716 |
92 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.99424950 |
93 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.99171743 |
94 | NFYA_21822215_ChIP-Seq_K562_Human | 0.98641157 |
95 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.96333193 |
96 | AR_25329375_ChIP-Seq_VCAP_Human | 0.96331723 |
97 | GATA3_26560356_Chip-Seq_TH1_Human | 0.95277132 |
98 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.95262874 |
99 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.95068738 |
100 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.94541414 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005377_hearing/vestibular/ear_phenot | 4.66238411 |
2 | MP0003878_abnormal_ear_physiology | 4.66238411 |
3 | MP0003698_abnormal_male_reproductive | 4.20288815 |
4 | MP0001929_abnormal_gametogenesis | 3.72192382 |
5 | MP0005670_abnormal_white_adipose | 3.66929706 |
6 | MP0001348_abnormal_lacrimal_gland | 3.37718692 |
7 | MP0000678_abnormal_parathyroid_gland | 2.50495045 |
8 | MP0002132_abnormal_respiratory_system | 2.39848086 |
9 | MP0003172_abnormal_lysosome_physiology | 2.30424966 |
10 | MP0002161_abnormal_fertility/fecundity | 2.24672581 |
11 | MP0003718_maternal_effect | 2.02384746 |
12 | MP0005410_abnormal_fertilization | 11.4245459 |
13 | MP0003646_muscle_fatigue | 1.96546112 |
14 | MP0005451_abnormal_body_composition | 1.63162677 |
15 | MP0009278_abnormal_bone_marrow | 1.61553172 |
16 | MP0002210_abnormal_sex_determination | 1.54779493 |
17 | MP0004742_abnormal_vestibular_system | 1.54426691 |
18 | MP0002249_abnormal_larynx_morphology | 1.53063326 |
19 | MP0005310_abnormal_salivary_gland | 1.52184442 |
20 | MP0003011_delayed_dark_adaptation | 1.50646876 |
21 | MP0005397_hematopoietic_system_phenotyp | 1.49787454 |
22 | MP0001545_abnormal_hematopoietic_system | 1.49787454 |
23 | MP0008057_abnormal_DNA_replication | 1.48573825 |
24 | MP0001765_abnormal_ion_homeostasis | 1.46021654 |
25 | MP0002822_catalepsy | 1.45303684 |
26 | MP0004510_myositis | 1.41245877 |
27 | MP0008995_early_reproductive_senescence | 1.39169621 |
28 | MP0005379_endocrine/exocrine_gland_phen | 1.33430961 |
29 | MP0001485_abnormal_pinna_reflex | 1.33411933 |
30 | MP0001835_abnormal_antigen_presentation | 1.30033552 |
31 | MP0001145_abnormal_male_reproductive | 1.30000344 |
32 | MP0003436_decreased_susceptibility_to | 1.25313609 |
33 | MP0000681_abnormal_thyroid_gland | 1.19888074 |
34 | MP0000653_abnormal_sex_gland | 1.19238333 |
35 | MP0003879_abnormal_hair_cell | 1.13290426 |
36 | MP0001486_abnormal_startle_reflex | 1.11846698 |
37 | MP0002127_abnormal_cardiovascular_syste | 1.11288314 |
38 | MP0002419_abnormal_innate_immunity | 1.09446959 |
39 | MP0005666_abnormal_adipose_tissue | 1.08870226 |
40 | MP0009785_altered_susceptibility_to | 1.03289633 |
41 | MP0001963_abnormal_hearing_physiology | 0.99088272 |
42 | MP0002229_neurodegeneration | 0.96195782 |
43 | MP0005464_abnormal_platelet_physiology | 0.92619810 |
44 | MP0003077_abnormal_cell_cycle | 0.91513443 |
45 | MP0002234_abnormal_pharynx_morphology | 0.91318937 |
46 | MP0005395_other_phenotype | 0.91140413 |
47 | MP0002282_abnormal_trachea_morphology | 0.90364561 |
48 | MP0005025_abnormal_response_to | 0.89937266 |
49 | MP0009115_abnormal_fat_cell | 0.89818898 |
50 | MP0005423_abnormal_somatic_nervous | 0.89511052 |
51 | MP0002735_abnormal_chemical_nociception | 0.88034383 |
52 | MP0001764_abnormal_homeostasis | 0.87644499 |
53 | MP0002733_abnormal_thermal_nociception | 0.83982430 |
54 | MP0004782_abnormal_surfactant_physiolog | 0.73896424 |
55 | MP0002138_abnormal_hepatobiliary_system | 0.73875237 |
56 | MP0000026_abnormal_inner_ear | 0.73624105 |
57 | MP0009053_abnormal_anal_canal | 0.73308492 |
58 | MP0010307_abnormal_tumor_latency | 0.72752964 |
59 | MP0005253_abnormal_eye_physiology | 0.71696789 |
60 | MP0002638_abnormal_pupillary_reflex | 0.70124363 |
61 | MP0005551_abnormal_eye_electrophysiolog | 0.69552466 |
62 | MP0000703_abnormal_thymus_morphology | 0.68999020 |
63 | MP0002723_abnormal_immune_serum | 0.68046575 |
64 | MP0001968_abnormal_touch/_nociception | 0.67925144 |
65 | MP0005375_adipose_tissue_phenotype | 0.66945367 |
66 | MP0008961_abnormal_basal_metabolism | 0.66230710 |
67 | MP0009764_decreased_sensitivity_to | 0.64420910 |
68 | MP0002722_abnormal_immune_system | 0.63468142 |
69 | MP0004808_abnormal_hematopoietic_stem | 0.63281767 |
70 | MP0003091_abnormal_cell_migration | 0.63108233 |
71 | MP0002398_abnormal_bone_marrow | 0.62590636 |
72 | MP0001800_abnormal_humoral_immune | 0.61296037 |
73 | MP0002928_abnormal_bile_duct | 0.58970164 |
74 | MP0005535_abnormal_body_temperature | 0.58624913 |
75 | MP0002452_abnormal_antigen_presenting | 0.58571996 |
76 | MP0002420_abnormal_adaptive_immunity | 0.57108918 |
77 | MP0003828_pulmonary_edema | 0.56228326 |
78 | MP0001819_abnormal_immune_cell | 0.56079300 |
79 | MP0005647_abnormal_sex_gland | 0.55613895 |
80 | MP0008877_abnormal_DNA_methylation | 0.55312198 |
81 | MP0004036_abnormal_muscle_relaxation | 0.52460603 |
82 | MP0000569_abnormal_digit_pigmentation | 0.52385415 |
83 | MP0000015_abnormal_ear_pigmentation | 0.50716336 |
84 | MP0000534_abnormal_ureter_morphology | 0.49175708 |
85 | MP0003303_peritoneal_inflammation | 0.48492352 |
86 | MP0005000_abnormal_immune_tolerance | 0.48256832 |
87 | MP0000249_abnormal_blood_vessel | 0.48133913 |
88 | MP0004085_abnormal_heartbeat | 0.47919623 |
89 | MP0000716_abnormal_immune_system | 0.47574558 |
90 | MP0004484_altered_response_of | 0.46783697 |
91 | MP0005083_abnormal_biliary_tract | 0.46399291 |
92 | MP0001666_abnormal_nutrient_absorption | 0.46223753 |
93 | MP0008469_abnormal_protein_level | 0.46069403 |
94 | MP0001986_abnormal_taste_sensitivity | 0.45995897 |
95 | MP0001501_abnormal_sleep_pattern | 0.45716883 |
96 | MP0002067_abnormal_sensory_capabilities | 0.45128577 |
97 | MP0002429_abnormal_blood_cell | 0.44955876 |
98 | MP0001533_abnormal_skeleton_physiology | 0.44305676 |
99 | MP0003699_abnormal_female_reproductive | 0.43871438 |
100 | MP0000313_abnormal_cell_death | 0.43413440 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Severe visual impairment (HP:0001141) | 8.20774374 |
2 | Attenuation of retinal blood vessels (HP:0007843) | 5.14255973 |
3 | Asymmetric septal hypertrophy (HP:0001670) | 5.02333329 |
4 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 4.95362426 |
5 | Absent/shortened dynein arms (HP:0200106) | 4.95362426 |
6 | Bony spicule pigmentary retinopathy (HP:0007737) | 4.92822121 |
7 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 4.72580494 |
8 | Resting tremor (HP:0002322) | 4.43074130 |
9 | Abnormal ciliary motility (HP:0012262) | 4.41017431 |
10 | Tubulointerstitial nephritis (HP:0001970) | 4.35566242 |
11 | Enlarged epiphyses (HP:0010580) | 4.27332129 |
12 | Abnormal rod and cone electroretinograms (HP:0008323) | 4.16461804 |
13 | Hyperkalemia (HP:0002153) | 4.16424641 |
14 | Male infertility (HP:0003251) | 4.14051874 |
15 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.99434573 |
16 | Nasal polyposis (HP:0100582) | 3.77202884 |
17 | Chronic hepatic failure (HP:0100626) | 3.68755186 |
18 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.68368453 |
19 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.68368453 |
20 | Bell-shaped thorax (HP:0001591) | 3.65746913 |
21 | Hypoplastic ischia (HP:0003175) | 3.60507402 |
22 | Infertility (HP:0000789) | 3.47406121 |
23 | Abnormality of macular pigmentation (HP:0008002) | 3.47372480 |
24 | Abnormal spermatogenesis (HP:0008669) | 3.43683321 |
25 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 3.33011925 |
26 | Cone-rod dystrophy (HP:0000548) | 3.28313908 |
27 | Azoospermia (HP:0000027) | 3.27869352 |
28 | Impulsivity (HP:0100710) | 3.07756967 |
29 | Hypoplasia of the thymus (HP:0000778) | 3.06039008 |
30 | Facial shape deformation (HP:0011334) | 3.05722168 |
31 | Potter facies (HP:0002009) | 3.05722168 |
32 | Abnormality of the nasal mucosa (HP:0000433) | 2.99805442 |
33 | Abnormality of the ischium (HP:0003174) | 2.95179676 |
34 | Progressive sensorineural hearing impairment (HP:0000408) | 2.82720051 |
35 | Bilateral sensorineural hearing impairment (HP:0008619) | 2.74500388 |
36 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.70546148 |
37 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.55914439 |
38 | Hypophosphatemic rickets (HP:0004912) | 2.48246230 |
39 | Abnormality of the aortic arch (HP:0012303) | 2.46014851 |
40 | Stage 5 chronic kidney disease (HP:0003774) | 2.42785977 |
41 | Portal hypertension (HP:0001409) | 2.41701282 |
42 | Truncal obesity (HP:0001956) | 2.40001969 |
43 | Nephronophthisis (HP:0000090) | 2.38473130 |
44 | Thrombocytosis (HP:0001894) | 2.34984953 |
45 | Abnormality of dental color (HP:0011073) | 2.32404594 |
46 | Postural instability (HP:0002172) | 2.31768770 |
47 | Abnormality of dentin (HP:0010299) | 2.30866054 |
48 | Abnormality of the costochondral junction (HP:0000919) | 2.28692661 |
49 | Abnormal urine output (HP:0012590) | 2.27555875 |
50 | Progressive hearing impairment (HP:0001730) | 2.25231054 |
51 | Abnormality of the hepatic vasculature (HP:0006707) | 2.22836011 |
52 | Abnormality of the parathyroid morphology (HP:0011766) | 2.22522071 |
53 | Rhinitis (HP:0012384) | 2.21628886 |
54 | Renal dysplasia (HP:0000110) | 2.19191736 |
55 | Abnormality of potassium homeostasis (HP:0011042) | 2.18305241 |
56 | Generalized aminoaciduria (HP:0002909) | 2.18276322 |
57 | Widely patent fontanelles and sutures (HP:0004492) | 2.16780019 |
58 | Epiphyseal dysplasia (HP:0002656) | 2.16104741 |
59 | Congenital malformation of the right heart (HP:0011723) | 2.15834037 |
60 | Double outlet right ventricle (HP:0001719) | 2.15834037 |
61 | Unilateral renal agenesis (HP:0000122) | 2.14335028 |
62 | Flattened epiphyses (HP:0003071) | 2.13574152 |
63 | Abnormal drinking behavior (HP:0030082) | 2.12787912 |
64 | Polydipsia (HP:0001959) | 2.12787912 |
65 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.11610063 |
66 | Abnormality of DNA repair (HP:0003254) | 2.06843158 |
67 | Abnormality of the renal medulla (HP:0100957) | 2.01098365 |
68 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.96736187 |
69 | Absent epiphyses (HP:0010577) | 1.96736187 |
70 | Horizontal nystagmus (HP:0000666) | 1.94344322 |
71 | Abnormality of the epiphysis of the femoral head (HP:0010574) | 1.93780491 |
72 | Progressive cerebellar ataxia (HP:0002073) | 1.93433174 |
73 | Muscle fiber atrophy (HP:0100295) | 1.92805788 |
74 | Polyuria (HP:0000103) | 1.90233128 |
75 | Abnormality of chloride homeostasis (HP:0011422) | 1.89443101 |
76 | Hyponatremia (HP:0002902) | 1.88031889 |
77 | Abnormality of the fingertips (HP:0001211) | 1.85014496 |
78 | Decreased central vision (HP:0007663) | 1.84341832 |
79 | Tubulointerstitial abnormality (HP:0001969) | 1.83851648 |
80 | Myositis (HP:0100614) | 1.82740882 |
81 | Abnormality of femoral epiphyses (HP:0006499) | 1.82335379 |
82 | Abnormality involving the epiphyses of the lower limbs (HP:0006500) | 1.82335379 |
83 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.81967524 |
84 | Amelogenesis imperfecta (HP:0000705) | 1.81653960 |
85 | Sandal gap (HP:0001852) | 1.81554147 |
86 | Bronchiectasis (HP:0002110) | 1.81436957 |
87 | Congenital sensorineural hearing impairment (HP:0008527) | 1.81259436 |
88 | Abnormality of renal excretion (HP:0011036) | 1.81051201 |
89 | Abnormality of the femoral head (HP:0003368) | 1.80255697 |
90 | Insulin-resistant diabetes mellitus (HP:0000831) | 1.78749788 |
91 | Hypoalphalipoproteinemia (HP:0003233) | 1.78538830 |
92 | Hypergonadotropic hypogonadism (HP:0000815) | 1.75870639 |
93 | Type 2 muscle fiber atrophy (HP:0003554) | 1.75132530 |
94 | Focal segmental glomerulosclerosis (HP:0000097) | 1.73815498 |
95 | Acute myeloid leukemia (HP:0004808) | 1.73533574 |
96 | Recurrent pneumonia (HP:0006532) | 1.73108321 |
97 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.72672547 |
98 | Scotoma (HP:0000575) | 1.70918800 |
99 | Prolonged bleeding time (HP:0003010) | 1.70829235 |
100 | Renovascular hypertension (HP:0100817) | 1.70750446 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PLK4 | 7.29662317 |
2 | TESK1 | 4.63526790 |
3 | DDR2 | 4.17828097 |
4 | BRD4 | 3.86441181 |
5 | INSRR | 3.61374353 |
6 | MAP4K2 | 3.09003733 |
7 | CDK12 | 2.94400932 |
8 | MST1R | 2.50139498 |
9 | WNK1 | 2.40139051 |
10 | PNCK | 2.36298930 |
11 | PLK2 | 2.31733366 |
12 | PIK3CG | 2.23100949 |
13 | STK38 | 2.19489931 |
14 | CAMK1G | 1.94854814 |
15 | SIK2 | 1.91041354 |
16 | MAPK15 | 1.82623804 |
17 | RIPK4 | 1.80388528 |
18 | KIT | 1.77232243 |
19 | PDPK1 | 1.59555496 |
20 | PDK1 | 1.58408466 |
21 | MAP3K13 | 1.34568231 |
22 | WNK4 | 1.32793582 |
23 | PRKD3 | 1.32520276 |
24 | CDK7 | 1.23890976 |
25 | BLK | 1.18703460 |
26 | PTK2B | 1.12762066 |
27 | MUSK | 1.11183242 |
28 | STK38L | 1.09986631 |
29 | PASK | 1.04198150 |
30 | FLT3 | 1.00579280 |
31 | PRKAA2 | 1.00031275 |
32 | CDK4 | 0.99245943 |
33 | KSR2 | 0.89677406 |
34 | TNK2 | 0.88871781 |
35 | JAK3 | 0.88415590 |
36 | DYRK1B | 0.87603143 |
37 | MARK2 | 0.84774618 |
38 | MAP3K7 | 0.83189273 |
39 | NEK6 | 0.83020329 |
40 | CAMK1D | 0.81954571 |
41 | TEC | 0.80667148 |
42 | TAOK3 | 0.73617876 |
43 | CSF1R | 0.72423586 |
44 | MAP2K2 | 0.70183364 |
45 | MAP3K11 | 0.69079995 |
46 | BTK | 0.67801101 |
47 | MAP2K6 | 0.60578946 |
48 | TESK2 | 0.60443878 |
49 | RPS6KA2 | 0.60196530 |
50 | ERN1 | 0.59026962 |
51 | PRKG2 | 0.58417264 |
52 | FES | 0.58252516 |
53 | CHEK1 | 0.57136777 |
54 | RPS6KL1 | 0.56464253 |
55 | RPS6KC1 | 0.56464253 |
56 | MTOR | 0.56407102 |
57 | MAPK11 | 0.55302977 |
58 | MARK3 | 0.54138842 |
59 | SYK | 0.53121974 |
60 | IKBKB | 0.52343647 |
61 | RPS6KA1 | 0.51548819 |
62 | CDK2 | 0.50626918 |
63 | MAP3K9 | 0.50363147 |
64 | MAPK1 | 0.50110627 |
65 | CDK1 | 0.49393500 |
66 | PRKG1 | 0.48991209 |
67 | CAMK1 | 0.48823533 |
68 | RPS6KA6 | 0.48476171 |
69 | SIK3 | 0.47385729 |
70 | PRPF4B | 0.44388295 |
71 | GSK3B | 0.43921981 |
72 | MAP3K8 | 0.42189215 |
73 | FRK | 0.40354485 |
74 | NEK2 | 0.40136407 |
75 | CAMK4 | 0.38189620 |
76 | ITK | 0.38165152 |
77 | CDK6 | 0.37713091 |
78 | JAK2 | 0.36519349 |
79 | MAP4K1 | 0.35261467 |
80 | CDK9 | 0.32216194 |
81 | AKT1 | 0.31832583 |
82 | NME1 | 0.31813345 |
83 | TYK2 | 0.31121127 |
84 | MAP2K3 | 0.30080001 |
85 | MAPK8 | 0.29797062 |
86 | SGK1 | 0.29699582 |
87 | MAP3K14 | 0.29152795 |
88 | MAP3K1 | 0.28929657 |
89 | TRIB3 | 0.28907478 |
90 | LYN | 0.27177486 |
91 | ZAP70 | 0.26985639 |
92 | MAPK14 | 0.26732527 |
93 | LCK | 0.25514326 |
94 | CDK19 | 0.25382238 |
95 | IRAK3 | 0.25295779 |
96 | HCK | 0.24414757 |
97 | CDK3 | 0.24081947 |
98 | PRKAA1 | 0.23564453 |
99 | MAPK10 | 0.23057567 |
100 | PRKCB | 0.20055430 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 6.20368622 |
2 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 3.72022450 |
3 | Olfactory transduction_Homo sapiens_hsa04740 | 3.65254638 |
4 | Allograft rejection_Homo sapiens_hsa05330 | 2.60715963 |
5 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.40275419 |
6 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.29879183 |
7 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.25382828 |
8 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.20195571 |
9 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.17560536 |
10 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.07641337 |
11 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.97132925 |
12 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.91977843 |
13 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.60657338 |
14 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.56920694 |
15 | Influenza A_Homo sapiens_hsa05164 | 1.51486682 |
16 | RNA transport_Homo sapiens_hsa03013 | 1.50575548 |
17 | Taste transduction_Homo sapiens_hsa04742 | 1.47704509 |
18 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.46393700 |
19 | Viral myocarditis_Homo sapiens_hsa05416 | 1.41194689 |
20 | ABC transporters_Homo sapiens_hsa02010 | 1.18295562 |
21 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.17460463 |
22 | Other glycan degradation_Homo sapiens_hsa00511 | 1.16817699 |
23 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.15430714 |
24 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.15120403 |
25 | Salivary secretion_Homo sapiens_hsa04970 | 1.14717133 |
26 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.09872366 |
27 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.08295385 |
28 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.06644739 |
29 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.04243219 |
30 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.03240872 |
31 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.96485678 |
32 | Endocytosis_Homo sapiens_hsa04144 | 0.95936877 |
33 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.92885431 |
34 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.89026529 |
35 | Leishmaniasis_Homo sapiens_hsa05140 | 0.88328228 |
36 | Legionellosis_Homo sapiens_hsa05134 | 0.87651670 |
37 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.87061466 |
38 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.85333755 |
39 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.84342206 |
40 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.84085396 |
41 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.83979069 |
42 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.82167846 |
43 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.80473066 |
44 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.80204912 |
45 | Basal transcription factors_Homo sapiens_hsa03022 | 0.77984168 |
46 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.76428160 |
47 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.74965280 |
48 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.74504298 |
49 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.74233266 |
50 | Lysine degradation_Homo sapiens_hsa00310 | 0.74109930 |
51 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.74090364 |
52 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.72891808 |
53 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.72758528 |
54 | Measles_Homo sapiens_hsa05162 | 0.71126877 |
55 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.68440298 |
56 | Phototransduction_Homo sapiens_hsa04744 | 0.68422768 |
57 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.68068398 |
58 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.67322119 |
59 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.67057782 |
60 | Platelet activation_Homo sapiens_hsa04611 | 0.64364431 |
61 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.64254678 |
62 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.63393070 |
63 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.63310464 |
64 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.62873718 |
65 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.62654601 |
66 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.62031549 |
67 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.60297106 |
68 | Base excision repair_Homo sapiens_hsa03410 | 0.58836114 |
69 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.58027679 |
70 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.56292459 |
71 | Asthma_Homo sapiens_hsa05310 | 0.54979845 |
72 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.53450754 |
73 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.52187758 |
74 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.50694795 |
75 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.49899764 |
76 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.49105978 |
77 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.48588798 |
78 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.47209853 |
79 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.45822422 |
80 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.45523671 |
81 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.45493642 |
82 | Circadian entrainment_Homo sapiens_hsa04713 | 0.44765920 |
83 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.44143114 |
84 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.43783536 |
85 | Morphine addiction_Homo sapiens_hsa05032 | 0.43068228 |
86 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.41538712 |
87 | Insulin resistance_Homo sapiens_hsa04931 | 0.37085824 |
88 | Malaria_Homo sapiens_hsa05144 | 0.36523403 |
89 | Purine metabolism_Homo sapiens_hsa00230 | 0.36452542 |
90 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.35903647 |
91 | Renin secretion_Homo sapiens_hsa04924 | 0.32660505 |
92 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.32416653 |
93 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.31901365 |
94 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.31792616 |
95 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.29815343 |
96 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.29798484 |
97 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.27056890 |
98 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.26718644 |
99 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.26657922 |
100 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.26537744 |