GOLGA8K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.86454945
2sperm capacitation (GO:0048240)9.79425314
3chromosome condensation (GO:0030261)9.27633272
4response to pheromone (GO:0019236)9.23432144
5DNA packaging (GO:0006323)8.91845179
6single strand break repair (GO:0000012)8.32585979
7spermatid nucleus differentiation (GO:0007289)8.01539485
8plasma membrane fusion (GO:0045026)7.40434600
9sperm-egg recognition (GO:0035036)7.33753519
10multicellular organism reproduction (GO:0032504)7.18472454
11rRNA methylation (GO:0031167)7.11949266
12microtubule depolymerization (GO:0007019)7.07067846
13spermatid development (GO:0007286)7.05258333
14reproduction (GO:0000003)6.75237410
15sexual reproduction (GO:0019953)6.55714880
16protein targeting to Golgi (GO:0000042)6.52257974
17binding of sperm to zona pellucida (GO:0007339)6.36879458
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.33078217
19establishment of protein localization to Golgi (GO:0072600)6.32920518
20negative regulation of inclusion body assembly (GO:0090084)6.32476312
21cell-cell recognition (GO:0009988)6.22780298
22retrograde transport, vesicle recycling within Golgi (GO:0000301)6.21204991
23rRNA modification (GO:0000154)5.90438482
24microtubule polymerization or depolymerization (GO:0031109)5.81836166
25protein polyglutamylation (GO:0018095)5.68322556
26spermatogenesis (GO:0007283)5.52264316
27male gamete generation (GO:0048232)5.50518266
28calcium ion-dependent exocytosis (GO:0017156)5.46827601
29axonemal dynein complex assembly (GO:0070286)5.38346001
30positive regulation of Rab GTPase activity (GO:0032851)5.31571222
31regulation of Rab GTPase activity (GO:0032313)5.31571222
32phosphatidylethanolamine biosynthetic process (GO:0006646)5.24433793
33centriole replication (GO:0007099)5.11610644
34chromatin silencing (GO:0006342)5.08271263
35gamete generation (GO:0007276)5.02879801
36microtubule severing (GO:0051013)4.99655335
37single fertilization (GO:0007338)4.96091137
38cellular ketone body metabolic process (GO:0046950)4.95728473
39cell wall macromolecule catabolic process (GO:0016998)4.95088439
40cilium or flagellum-dependent cell motility (GO:0001539)4.89208195
41phosphatidylethanolamine metabolic process (GO:0046337)4.75251590
42motile cilium assembly (GO:0044458)4.65024338
43protein localization to Golgi apparatus (GO:0034067)4.63426294
44cell wall macromolecule metabolic process (GO:0044036)4.59842677
45centriole assembly (GO:0098534)4.42062841
46RNA destabilization (GO:0050779)4.37950870
47ketone body metabolic process (GO:1902224)4.30465574
48regulation of inclusion body assembly (GO:0090083)4.21535912
49nucleus organization (GO:0006997)4.15583480
50fertilization (GO:0009566)4.07207855
51glycerol ether metabolic process (GO:0006662)4.05539259
52regulation of cilium movement (GO:0003352)4.03404130
53cellular process involved in reproduction in multicellular organism (GO:0022412)4.03349696
54multicellular organismal reproductive process (GO:0048609)4.01787643
55germ cell development (GO:0007281)4.00944230
56seminiferous tubule development (GO:0072520)3.94307421
57regulation of centriole replication (GO:0046599)3.91885258
58regulation of ARF GTPase activity (GO:0032312)3.91458772
59negative regulation of gene expression, epigenetic (GO:0045814)3.85335784
60ether metabolic process (GO:0018904)3.72077438
61histone H3-K9 demethylation (GO:0033169)3.69676752
62negative regulation of Rho protein signal transduction (GO:0035024)3.54372252
63negative regulation of histone methylation (GO:0031061)3.47523344
64DNA conformation change (GO:0071103)3.45339071
65negative regulation of granulocyte differentiation (GO:0030853)3.40417370
66nucleosome disassembly (GO:0006337)3.34589075
67protein-DNA complex disassembly (GO:0032986)3.34589075
68epithelial cilium movement (GO:0003351)3.34062799
69regulation of transcription involved in cell fate commitment (GO:0060850)3.33899568
70coenzyme catabolic process (GO:0009109)3.28184266
71cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.25273522
72regulation of histone H3-K27 methylation (GO:0061085)3.17826044
73histone H3-K36 demethylation (GO:0070544)3.17731417
74cilium movement (GO:0003341)3.10175379
75regulation of T-helper 2 cell differentiation (GO:0045628)3.09920878
76microtubule nucleation (GO:0007020)3.08050937
77homeostasis of number of cells within a tissue (GO:0048873)2.97065073
78peptidyl-threonine dephosphorylation (GO:0035970)2.92749408
79cranial nerve morphogenesis (GO:0021602)2.85930878
80detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.83621457
81cell recognition (GO:0008037)2.82875479
82gene silencing (GO:0016458)2.82545635
83NAD biosynthetic process (GO:0009435)2.82234766
84protein depolymerization (GO:0051261)2.81954811
85polyamine biosynthetic process (GO:0006596)2.79730367
86histone H4 deacetylation (GO:0070933)2.79688778
87cerebral cortex neuron differentiation (GO:0021895)2.79433049
88DNA methylation involved in gamete generation (GO:0043046)2.77484654
89membrane protein intracellular domain proteolysis (GO:0031293)2.77123274
90piRNA metabolic process (GO:0034587)2.74833702
91glomerular visceral epithelial cell development (GO:0072015)2.73699499
92multicellular organismal movement (GO:0050879)2.72936619
93musculoskeletal movement (GO:0050881)2.72936619
94peptidyl-proline hydroxylation (GO:0019511)2.71623199
95multicellular organismal development (GO:0007275)2.71182169
96cell differentiation involved in metanephros development (GO:0072202)2.70567458
97peptide catabolic process (GO:0043171)2.68392108
98regulation of microtubule-based movement (GO:0060632)2.67675319
99sperm motility (GO:0030317)10.7974206
100acrosome reaction (GO:0007340)10.7371830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.18830127
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.33904416
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.28648516
4VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.58774832
5ELF1_20517297_ChIP-Seq_JURKAT_Human2.42815115
6DROSHA_22980978_ChIP-Seq_HELA_Human2.25481385
7BCL6_27268052_Chip-Seq_Bcells_Human2.21259958
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.10502755
9ERA_21632823_ChIP-Seq_H3396_Human2.08422385
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.07860392
11CBP_20019798_ChIP-Seq_JUKART_Human2.07860392
12RAC3_21632823_ChIP-Seq_H3396_Human2.07371684
13EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.07026755
14POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.05178442
15TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05178442
16WDR5_24793694_ChIP-Seq_LNCAP_Human2.01391590
17BCOR_27268052_Chip-Seq_Bcells_Human1.99162783
18E2F1_20622854_ChIP-Seq_HELA_Human1.98600086
19EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.96737176
20RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.96159639
21SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.95386669
22P68_20966046_ChIP-Seq_HELA_Human1.92726118
23SMC4_20622854_ChIP-Seq_HELA_Human1.90416097
24RUNX_20019798_ChIP-Seq_JUKART_Human1.85994074
25NANOG_20526341_ChIP-Seq_ESCs_Human1.82714952
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78467045
27PHF8_20622854_ChIP-Seq_HELA_Human1.73345306
28YY1_22570637_ChIP-Seq_MALME-3M_Human1.66917366
29LXR_22292898_ChIP-Seq_THP-1_Human1.64912949
30TAF2_19829295_ChIP-Seq_ESCs_Human1.59397135
31SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.58974269
32P300_27268052_Chip-Seq_Bcells_Human1.58056941
33TP63_22573176_ChIP-Seq_HFKS_Human1.57432340
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55930260
35CTCF_20526341_ChIP-Seq_ESCs_Human1.55735108
36CTCF_27219007_Chip-Seq_Bcells_Human1.55428378
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55113883
38OCT4_20526341_ChIP-Seq_ESCs_Human1.55099757
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.54049532
40ER_23166858_ChIP-Seq_MCF-7_Human1.51499754
41MYC_19829295_ChIP-Seq_ESCs_Human1.49412918
42VDR_24787735_ChIP-Seq_THP-1_Human1.48215584
43GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46397092
44CEBPB_22108803_ChIP-Seq_LS180_Human1.42465988
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.41488824
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39094351
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38847123
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.37912631
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36779291
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34476771
51SPI1_20517297_ChIP-Seq_HL60_Human1.33910149
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33649810
53FUS_26573619_Chip-Seq_HEK293_Human1.30477547
54HNFA_21074721_ChIP-Seq_CACO-2_Human1.30311278
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28580019
56SPI1_23127762_ChIP-Seq_K562_Human1.27365230
57SA1_27219007_Chip-Seq_Bcells_Human1.26795820
58P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26097562
59GATA1_19941826_ChIP-Seq_K562_Human1.26042453
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25963937
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25918564
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.24936460
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23626812
64ZNF274_21170338_ChIP-Seq_K562_Hela1.22799427
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22327105
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20562486
67CBX2_22325352_ChIP-Seq_293T-Rex_Human1.18619495
68RBPJ_21746931_ChIP-Seq_IB4_Human1.18443861
69SMRT_27268052_Chip-Seq_Bcells_Human1.18268246
70MYB_26560356_Chip-Seq_TH2_Human1.17935567
71VDR_24763502_ChIP-Seq_THP-1_Human1.17004202
72P53_21459846_ChIP-Seq_SAOS-2_Human1.16378005
73ETV1_20927104_ChIP-Seq_GIST48_Human1.15994626
74NFYB_21822215_ChIP-Seq_K562_Human1.15573693
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13986434
76OCT4_19829295_ChIP-Seq_ESCs_Human1.13346181
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.12823255
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10318590
79TAF15_26573619_Chip-Seq_HEK293_Human1.09874091
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07711515
81SOX2_22085726_ChIP-Seq_NPCs_Mouse1.07249779
82ERG_20517297_ChIP-Seq_VCAP_Human1.06430060
83SCL_19346495_ChIP-Seq_HPC-7_Human1.05725530
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05675060
85VDR_21846776_ChIP-Seq_THP-1_Human1.05545502
86TBL1_22424771_ChIP-Seq_293T_Human1.04257930
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.04177185
88E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03535349
89FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01944497
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.01300666
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.00472716
92TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.99424950
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99171743
94NFYA_21822215_ChIP-Seq_K562_Human0.98641157
95KLF4_19829295_ChIP-Seq_ESCs_Human0.96333193
96AR_25329375_ChIP-Seq_VCAP_Human0.96331723
97GATA3_26560356_Chip-Seq_TH1_Human0.95277132
98STAT1_20625510_ChIP-Seq_HELA_Human0.95262874
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.95068738
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94541414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.66238411
2MP0005377_hearing/vestibular/ear_phenot4.66238411
3MP0003698_abnormal_male_reproductive4.20288815
4MP0001929_abnormal_gametogenesis3.72192382
5MP0005670_abnormal_white_adipose3.66929706
6MP0001348_abnormal_lacrimal_gland3.37718692
7MP0000678_abnormal_parathyroid_gland2.50495045
8MP0002132_abnormal_respiratory_system2.39848086
9MP0003172_abnormal_lysosome_physiology2.30424966
10MP0002161_abnormal_fertility/fecundity2.24672581
11MP0003718_maternal_effect2.02384746
12MP0005410_abnormal_fertilization11.4245459
13MP0003646_muscle_fatigue1.96546112
14MP0005451_abnormal_body_composition1.63162677
15MP0009278_abnormal_bone_marrow1.61553172
16MP0002210_abnormal_sex_determination1.54779493
17MP0004742_abnormal_vestibular_system1.54426691
18MP0002249_abnormal_larynx_morphology1.53063326
19MP0005310_abnormal_salivary_gland1.52184442
20MP0003011_delayed_dark_adaptation1.50646876
21MP0001545_abnormal_hematopoietic_system1.49787454
22MP0005397_hematopoietic_system_phenotyp1.49787454
23MP0008057_abnormal_DNA_replication1.48573825
24MP0001765_abnormal_ion_homeostasis1.46021654
25MP0002822_catalepsy1.45303684
26MP0004510_myositis1.41245877
27MP0008995_early_reproductive_senescence1.39169621
28MP0005379_endocrine/exocrine_gland_phen1.33430961
29MP0001485_abnormal_pinna_reflex1.33411933
30MP0001835_abnormal_antigen_presentation1.30033552
31MP0001145_abnormal_male_reproductive1.30000344
32MP0003436_decreased_susceptibility_to1.25313609
33MP0000681_abnormal_thyroid_gland1.19888074
34MP0000653_abnormal_sex_gland1.19238333
35MP0003879_abnormal_hair_cell1.13290426
36MP0001486_abnormal_startle_reflex1.11846698
37MP0002127_abnormal_cardiovascular_syste1.11288314
38MP0002419_abnormal_innate_immunity1.09446959
39MP0005666_abnormal_adipose_tissue1.08870226
40MP0009785_altered_susceptibility_to1.03289633
41MP0001963_abnormal_hearing_physiology0.99088272
42MP0002229_neurodegeneration0.96195782
43MP0005464_abnormal_platelet_physiology0.92619810
44MP0003077_abnormal_cell_cycle0.91513443
45MP0002234_abnormal_pharynx_morphology0.91318937
46MP0005395_other_phenotype0.91140413
47MP0002282_abnormal_trachea_morphology0.90364561
48MP0005025_abnormal_response_to0.89937266
49MP0009115_abnormal_fat_cell0.89818898
50MP0005423_abnormal_somatic_nervous0.89511052
51MP0002735_abnormal_chemical_nociception0.88034383
52MP0001764_abnormal_homeostasis0.87644499
53MP0002733_abnormal_thermal_nociception0.83982430
54MP0004782_abnormal_surfactant_physiolog0.73896424
55MP0002138_abnormal_hepatobiliary_system0.73875237
56MP0000026_abnormal_inner_ear0.73624105
57MP0009053_abnormal_anal_canal0.73308492
58MP0010307_abnormal_tumor_latency0.72752964
59MP0005253_abnormal_eye_physiology0.71696789
60MP0002638_abnormal_pupillary_reflex0.70124363
61MP0005551_abnormal_eye_electrophysiolog0.69552466
62MP0000703_abnormal_thymus_morphology0.68999020
63MP0002723_abnormal_immune_serum0.68046575
64MP0001968_abnormal_touch/_nociception0.67925144
65MP0005375_adipose_tissue_phenotype0.66945367
66MP0008961_abnormal_basal_metabolism0.66230710
67MP0009764_decreased_sensitivity_to0.64420910
68MP0002722_abnormal_immune_system0.63468142
69MP0004808_abnormal_hematopoietic_stem0.63281767
70MP0003091_abnormal_cell_migration0.63108233
71MP0002398_abnormal_bone_marrow0.62590636
72MP0001800_abnormal_humoral_immune0.61296037
73MP0002928_abnormal_bile_duct0.58970164
74MP0005535_abnormal_body_temperature0.58624913
75MP0002452_abnormal_antigen_presenting0.58571996
76MP0002420_abnormal_adaptive_immunity0.57108918
77MP0003828_pulmonary_edema0.56228326
78MP0001819_abnormal_immune_cell0.56079300
79MP0005647_abnormal_sex_gland0.55613895
80MP0008877_abnormal_DNA_methylation0.55312198
81MP0004036_abnormal_muscle_relaxation0.52460603
82MP0000569_abnormal_digit_pigmentation0.52385415
83MP0000015_abnormal_ear_pigmentation0.50716336
84MP0000534_abnormal_ureter_morphology0.49175708
85MP0003303_peritoneal_inflammation0.48492352
86MP0005000_abnormal_immune_tolerance0.48256832
87MP0000249_abnormal_blood_vessel0.48133913
88MP0004085_abnormal_heartbeat0.47919623
89MP0000716_abnormal_immune_system0.47574558
90MP0004484_altered_response_of0.46783697
91MP0005083_abnormal_biliary_tract0.46399291
92MP0001666_abnormal_nutrient_absorption0.46223753
93MP0008469_abnormal_protein_level0.46069403
94MP0001986_abnormal_taste_sensitivity0.45995897
95MP0001501_abnormal_sleep_pattern0.45716883
96MP0002067_abnormal_sensory_capabilities0.45128577
97MP0002429_abnormal_blood_cell0.44955876
98MP0001533_abnormal_skeleton_physiology0.44305676
99MP0003699_abnormal_female_reproductive0.43871438
100MP0000313_abnormal_cell_death0.43413440

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.20774374
2Attenuation of retinal blood vessels (HP:0007843)5.14255973
3Asymmetric septal hypertrophy (HP:0001670)5.02333329
4Absent/shortened dynein arms (HP:0200106)4.95362426
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.95362426
6Bony spicule pigmentary retinopathy (HP:0007737)4.92822121
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.72580494
8Resting tremor (HP:0002322)4.43074130
9Abnormal ciliary motility (HP:0012262)4.41017431
10Tubulointerstitial nephritis (HP:0001970)4.35566242
11Enlarged epiphyses (HP:0010580)4.27332129
12Abnormal rod and cone electroretinograms (HP:0008323)4.16461804
13Hyperkalemia (HP:0002153)4.16424641
14Male infertility (HP:0003251)4.14051874
15Abnormal respiratory motile cilium physiology (HP:0012261)3.99434573
16Nasal polyposis (HP:0100582)3.77202884
17Chronic hepatic failure (HP:0100626)3.68755186
18Abnormal respiratory epithelium morphology (HP:0012253)3.68368453
19Abnormal respiratory motile cilium morphology (HP:0005938)3.68368453
20Bell-shaped thorax (HP:0001591)3.65746913
21Hypoplastic ischia (HP:0003175)3.60507402
22Infertility (HP:0000789)3.47406121
23Abnormality of macular pigmentation (HP:0008002)3.47372480
24Abnormal spermatogenesis (HP:0008669)3.43683321
25Aplasia/Hypoplasia of the earlobes (HP:0009906)3.33011925
26Cone-rod dystrophy (HP:0000548)3.28313908
27Azoospermia (HP:0000027)3.27869352
28Impulsivity (HP:0100710)3.07756967
29Hypoplasia of the thymus (HP:0000778)3.06039008
30Facial shape deformation (HP:0011334)3.05722168
31Potter facies (HP:0002009)3.05722168
32Abnormality of the nasal mucosa (HP:0000433)2.99805442
33Abnormality of the ischium (HP:0003174)2.95179676
34Progressive sensorineural hearing impairment (HP:0000408)2.82720051
35Bilateral sensorineural hearing impairment (HP:0008619)2.74500388
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.70546148
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.55914439
38Hypophosphatemic rickets (HP:0004912)2.48246230
39Abnormality of the aortic arch (HP:0012303)2.46014851
40Stage 5 chronic kidney disease (HP:0003774)2.42785977
41Portal hypertension (HP:0001409)2.41701282
42Truncal obesity (HP:0001956)2.40001969
43Nephronophthisis (HP:0000090)2.38473130
44Thrombocytosis (HP:0001894)2.34984953
45Abnormality of dental color (HP:0011073)2.32404594
46Postural instability (HP:0002172)2.31768770
47Abnormality of dentin (HP:0010299)2.30866054
48Abnormality of the costochondral junction (HP:0000919)2.28692661
49Abnormal urine output (HP:0012590)2.27555875
50Progressive hearing impairment (HP:0001730)2.25231054
51Abnormality of the hepatic vasculature (HP:0006707)2.22836011
52Abnormality of the parathyroid morphology (HP:0011766)2.22522071
53Rhinitis (HP:0012384)2.21628886
54Renal dysplasia (HP:0000110)2.19191736
55Abnormality of potassium homeostasis (HP:0011042)2.18305241
56Generalized aminoaciduria (HP:0002909)2.18276322
57Widely patent fontanelles and sutures (HP:0004492)2.16780019
58Epiphyseal dysplasia (HP:0002656)2.16104741
59Double outlet right ventricle (HP:0001719)2.15834037
60Congenital malformation of the right heart (HP:0011723)2.15834037
61Unilateral renal agenesis (HP:0000122)2.14335028
62Flattened epiphyses (HP:0003071)2.13574152
63Abnormal drinking behavior (HP:0030082)2.12787912
64Polydipsia (HP:0001959)2.12787912
65Aplasia/Hypoplasia of the thymus (HP:0010515)2.11610063
66Abnormality of DNA repair (HP:0003254)2.06843158
67Abnormality of the renal medulla (HP:0100957)2.01098365
68Absent epiphyses (HP:0010577)1.96736187
69Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96736187
70Horizontal nystagmus (HP:0000666)1.94344322
71Abnormality of the epiphysis of the femoral head (HP:0010574)1.93780491
72Progressive cerebellar ataxia (HP:0002073)1.93433174
73Muscle fiber atrophy (HP:0100295)1.92805788
74Polyuria (HP:0000103)1.90233128
75Abnormality of chloride homeostasis (HP:0011422)1.89443101
76Hyponatremia (HP:0002902)1.88031889
77Abnormality of the fingertips (HP:0001211)1.85014496
78Decreased central vision (HP:0007663)1.84341832
79Tubulointerstitial abnormality (HP:0001969)1.83851648
80Myositis (HP:0100614)1.82740882
81Abnormality of femoral epiphyses (HP:0006499)1.82335379
82Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.82335379
83Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.81967524
84Amelogenesis imperfecta (HP:0000705)1.81653960
85Sandal gap (HP:0001852)1.81554147
86Bronchiectasis (HP:0002110)1.81436957
87Congenital sensorineural hearing impairment (HP:0008527)1.81259436
88Abnormality of renal excretion (HP:0011036)1.81051201
89Abnormality of the femoral head (HP:0003368)1.80255697
90Insulin-resistant diabetes mellitus (HP:0000831)1.78749788
91Hypoalphalipoproteinemia (HP:0003233)1.78538830
92Hypergonadotropic hypogonadism (HP:0000815)1.75870639
93Type 2 muscle fiber atrophy (HP:0003554)1.75132530
94Focal segmental glomerulosclerosis (HP:0000097)1.73815498
95Acute myeloid leukemia (HP:0004808)1.73533574
96Recurrent pneumonia (HP:0006532)1.73108321
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72672547
98Scotoma (HP:0000575)1.70918800
99Prolonged bleeding time (HP:0003010)1.70829235
100Renovascular hypertension (HP:0100817)1.70750446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.29662317
2TESK14.63526790
3DDR24.17828097
4BRD43.86441181
5INSRR3.61374353
6MAP4K23.09003733
7CDK122.94400932
8MST1R2.50139498
9WNK12.40139051
10PNCK2.36298930
11PLK22.31733366
12PIK3CG2.23100949
13STK382.19489931
14CAMK1G1.94854814
15SIK21.91041354
16MAPK151.82623804
17RIPK41.80388528
18KIT1.77232243
19PDPK11.59555496
20PDK11.58408466
21MAP3K131.34568231
22WNK41.32793582
23PRKD31.32520276
24CDK71.23890976
25BLK1.18703460
26PTK2B1.12762066
27MUSK1.11183242
28STK38L1.09986631
29PASK1.04198150
30FLT31.00579280
31PRKAA21.00031275
32CDK40.99245943
33KSR20.89677406
34TNK20.88871781
35JAK30.88415590
36DYRK1B0.87603143
37MARK20.84774618
38MAP3K70.83189273
39NEK60.83020329
40CAMK1D0.81954571
41TEC0.80667148
42TAOK30.73617876
43CSF1R0.72423586
44MAP2K20.70183364
45MAP3K110.69079995
46BTK0.67801101
47MAP2K60.60578946
48TESK20.60443878
49RPS6KA20.60196530
50ERN10.59026962
51PRKG20.58417264
52FES0.58252516
53CHEK10.57136777
54RPS6KC10.56464253
55RPS6KL10.56464253
56MTOR0.56407102
57MAPK110.55302977
58MARK30.54138842
59SYK0.53121974
60IKBKB0.52343647
61RPS6KA10.51548819
62CDK20.50626918
63MAP3K90.50363147
64MAPK10.50110627
65CDK10.49393500
66PRKG10.48991209
67CAMK10.48823533
68RPS6KA60.48476171
69SIK30.47385729
70PRPF4B0.44388295
71GSK3B0.43921981
72MAP3K80.42189215
73FRK0.40354485
74NEK20.40136407
75CAMK40.38189620
76ITK0.38165152
77CDK60.37713091
78JAK20.36519349
79MAP4K10.35261467
80CDK90.32216194
81AKT10.31832583
82NME10.31813345
83TYK20.31121127
84MAP2K30.30080001
85MAPK80.29797062
86SGK10.29699582
87MAP3K140.29152795
88MAP3K10.28929657
89TRIB30.28907478
90LYN0.27177486
91ZAP700.26985639
92MAPK140.26732527
93LCK0.25514326
94CDK190.25382238
95IRAK30.25295779
96HCK0.24414757
97CDK30.24081947
98PRKAA10.23564453
99MAPK100.23057567
100PRKCB0.20055430

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.20368622
2Fatty acid biosynthesis_Homo sapiens_hsa000613.72022450
3Olfactory transduction_Homo sapiens_hsa047403.65254638
4Allograft rejection_Homo sapiens_hsa053302.60715963
5Autoimmune thyroid disease_Homo sapiens_hsa053202.40275419
6Graft-versus-host disease_Homo sapiens_hsa053322.29879183
7Type I diabetes mellitus_Homo sapiens_hsa049402.25382828
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20195571
9Antigen processing and presentation_Homo sapiens_hsa046122.17560536
10Butanoate metabolism_Homo sapiens_hsa006502.07641337
11Glycerophospholipid metabolism_Homo sapiens_hsa005641.97132925
12Dorso-ventral axis formation_Homo sapiens_hsa043201.91977843
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.60657338
14Type II diabetes mellitus_Homo sapiens_hsa049301.56920694
15Influenza A_Homo sapiens_hsa051641.51486682
16RNA transport_Homo sapiens_hsa030131.50575548
17Taste transduction_Homo sapiens_hsa047421.47704509
18Acute myeloid leukemia_Homo sapiens_hsa052211.46393700
19Viral myocarditis_Homo sapiens_hsa054161.41194689
20ABC transporters_Homo sapiens_hsa020101.18295562
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.17460463
22Other glycan degradation_Homo sapiens_hsa005111.16817699
23Herpes simplex infection_Homo sapiens_hsa051681.15430714
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15120403
25Salivary secretion_Homo sapiens_hsa049701.14717133
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09872366
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08295385
28Inositol phosphate metabolism_Homo sapiens_hsa005621.06644739
29B cell receptor signaling pathway_Homo sapiens_hsa046621.04243219
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03240872
31Fanconi anemia pathway_Homo sapiens_hsa034600.96485678
32Endocytosis_Homo sapiens_hsa041440.95936877
33Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92885431
34Oocyte meiosis_Homo sapiens_hsa041140.89026529
35Leishmaniasis_Homo sapiens_hsa051400.88328228
36Legionellosis_Homo sapiens_hsa051340.87651670
37Fatty acid metabolism_Homo sapiens_hsa012120.87061466
38Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85333755
39Glycosaminoglycan degradation_Homo sapiens_hsa005310.84342206
40Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84085396
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.83979069
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82167846
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80473066
44Selenocompound metabolism_Homo sapiens_hsa004500.80204912
45Basal transcription factors_Homo sapiens_hsa030220.77984168
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76428160
47Toxoplasmosis_Homo sapiens_hsa051450.74965280
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74504298
49Notch signaling pathway_Homo sapiens_hsa043300.74233266
50Lysine degradation_Homo sapiens_hsa003100.74109930
51Osteoclast differentiation_Homo sapiens_hsa043800.74090364
52Calcium signaling pathway_Homo sapiens_hsa040200.72891808
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72758528
54Measles_Homo sapiens_hsa051620.71126877
55Fatty acid degradation_Homo sapiens_hsa000710.68440298
56Phototransduction_Homo sapiens_hsa047440.68422768
57Viral carcinogenesis_Homo sapiens_hsa052030.68068398
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67322119
59Protein digestion and absorption_Homo sapiens_hsa049740.67057782
60Platelet activation_Homo sapiens_hsa046110.64364431
61VEGF signaling pathway_Homo sapiens_hsa043700.64254678
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63393070
63mRNA surveillance pathway_Homo sapiens_hsa030150.63310464
64Arginine and proline metabolism_Homo sapiens_hsa003300.62873718
65Glycerolipid metabolism_Homo sapiens_hsa005610.62654601
66Estrogen signaling pathway_Homo sapiens_hsa049150.62031549
67T cell receptor signaling pathway_Homo sapiens_hsa046600.60297106
68Base excision repair_Homo sapiens_hsa034100.58836114
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58027679
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56292459
71Asthma_Homo sapiens_hsa053100.54979845
72Non-small cell lung cancer_Homo sapiens_hsa052230.53450754
73Renin-angiotensin system_Homo sapiens_hsa046140.52187758
74Epstein-Barr virus infection_Homo sapiens_hsa051690.50694795
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49899764
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.49105978
77Staphylococcus aureus infection_Homo sapiens_hsa051500.48588798
78Prolactin signaling pathway_Homo sapiens_hsa049170.47209853
79Hematopoietic cell lineage_Homo sapiens_hsa046400.45822422
80Chemokine signaling pathway_Homo sapiens_hsa040620.45523671
81Pancreatic secretion_Homo sapiens_hsa049720.45493642
82Circadian entrainment_Homo sapiens_hsa047130.44765920
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44143114
84cAMP signaling pathway_Homo sapiens_hsa040240.43783536
85Morphine addiction_Homo sapiens_hsa050320.43068228
86Choline metabolism in cancer_Homo sapiens_hsa052310.41538712
87Insulin resistance_Homo sapiens_hsa049310.37085824
88Malaria_Homo sapiens_hsa051440.36523403
89Purine metabolism_Homo sapiens_hsa002300.36452542
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35903647
91Renin secretion_Homo sapiens_hsa049240.32660505
92Phenylalanine metabolism_Homo sapiens_hsa003600.32416653
93MAPK signaling pathway_Homo sapiens_hsa040100.31901365
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.31792616
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.29815343
96Cholinergic synapse_Homo sapiens_hsa047250.29798484
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.27056890
98TNF signaling pathway_Homo sapiens_hsa046680.26718644
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26657922
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26537744

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