GOLGA8M

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of autophagic vacuole assembly (GO:2000785)5.67261487
2cell wall macromolecule metabolic process (GO:0044036)5.37971706
3cellular response to zinc ion (GO:0071294)4.98204655
4poly(A)+ mRNA export from nucleus (GO:0016973)4.97333420
5positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.72410325
6regulation of vacuole organization (GO:0044088)4.65124150
7coenzyme catabolic process (GO:0009109)4.64272436
8cell wall macromolecule catabolic process (GO:0016998)4.49147786
9positive regulation of catecholamine secretion (GO:0033605)4.46848980
10mannose metabolic process (GO:0006013)4.39375233
11regulation of phosphoprotein phosphatase activity (GO:0043666)4.11315875
12histone H3-K36 demethylation (GO:0070544)3.97920037
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.84668487
14positive regulation of gamma-delta T cell activation (GO:0046645)3.73700612
15negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.73478450
16mRNA cleavage (GO:0006379)3.68883489
17regulation of oxidative stress-induced neuron death (GO:1903203)3.66534341
18mature B cell differentiation involved in immune response (GO:0002313)3.60823580
19ADP metabolic process (GO:0046031)3.55849742
20cellular extravasation (GO:0045123)3.44844865
21negative regulation of smooth muscle cell proliferation (GO:0048662)3.42655941
22cellular response to lithium ion (GO:0071285)3.41985796
23regulation of mast cell degranulation (GO:0043304)3.40220007
24positive regulation of B cell differentiation (GO:0045579)3.34905131
25regulation of B cell differentiation (GO:0045577)3.31992240
26response to peptidoglycan (GO:0032494)3.31179531
27regulation of phospholipase A2 activity (GO:0032429)3.29044797
28regulation of oxidative phosphorylation (GO:0002082)3.28070117
29regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27250830
30activation of protein kinase B activity (GO:0032148)3.26698538
31negative regulation of T cell apoptotic process (GO:0070233)3.20543023
32negative regulation of defense response to virus (GO:0050687)3.17852234
33motile cilium assembly (GO:0044458)3.16823887
34response to muramyl dipeptide (GO:0032495)3.15637183
35neutrophil activation involved in immune response (GO:0002283)3.11773460
36regulation of mast cell activation involved in immune response (GO:0033006)3.10987465
37AMP metabolic process (GO:0046033)3.09479240
38positive regulation of granulocyte differentiation (GO:0030854)3.08212524
39diacylglycerol metabolic process (GO:0046339)3.07680163
40thyroid gland development (GO:0030878)3.06534507
41neutrophil mediated immunity (GO:0002446)3.03406354
42regulation of hypersensitivity (GO:0002883)3.00064654
43regulation of B cell receptor signaling pathway (GO:0050855)2.99155357
44negative regulation of interleukin-17 production (GO:0032700)2.98583941
45TOR signaling (GO:0031929)2.96364722
46negative regulation of erythrocyte differentiation (GO:0045647)2.95998705
47multicellular organism reproduction (GO:0032504)2.89973665
48regulation of leukocyte degranulation (GO:0043300)2.87682775
49sleep (GO:0030431)2.87579932
50mature B cell differentiation (GO:0002335)2.87145136
51modulation of growth of symbiont involved in interaction with host (GO:0044144)2.85309983
52regulation of growth of symbiont in host (GO:0044126)2.85309983
53negative regulation of growth of symbiont in host (GO:0044130)2.85309983
54negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.85309983
55positive regulation of protein kinase C signaling (GO:0090037)2.85248709
56negative regulation of necrotic cell death (GO:0060547)2.84829227
57B cell receptor signaling pathway (GO:0050853)2.84073455
58regulation of germinal center formation (GO:0002634)2.83812186
59positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.83564867
60DNA double-strand break processing (GO:0000729)2.80288653
61negative regulation of interleukin-8 production (GO:0032717)2.79428918
62potassium ion export (GO:0071435)2.78394525
63regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.77547643
64purinergic nucleotide receptor signaling pathway (GO:0035590)2.77027483
65positive regulation of myoblast differentiation (GO:0045663)2.75552302
66oligosaccharide biosynthetic process (GO:0009312)2.74940899
67regulation of gamma-delta T cell differentiation (GO:0045586)2.74248335
68positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.73930410
69response to muscle activity (GO:0014850)2.73536753
70negative regulation of necroptotic process (GO:0060546)2.72615571
71mast cell activation involved in immune response (GO:0002279)2.72514707
72mast cell degranulation (GO:0043303)2.72514707
73androgen biosynthetic process (GO:0006702)2.72463549
74regulation of gamma-delta T cell activation (GO:0046643)2.71054920
75regulation of ARF GTPase activity (GO:0032312)2.68343279
76detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.66851603
77negative regulation of type I interferon production (GO:0032480)2.66641947
78regulation of granulocyte differentiation (GO:0030852)2.66352319
79positive regulation of T cell cytokine production (GO:0002726)2.65648994
80negative regulation of cell killing (GO:0031342)2.65029085
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65029085
82response to zinc ion (GO:0010043)2.64931390
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64768569
84regulation of mast cell activation (GO:0033003)2.64728962
85L-fucose catabolic process (GO:0042355)2.63802462
86fucose catabolic process (GO:0019317)2.63802462
87L-fucose metabolic process (GO:0042354)2.63802462
88definitive hemopoiesis (GO:0060216)2.61962366
893-UTR-mediated mRNA stabilization (GO:0070935)2.59830704
90negative regulation of bone resorption (GO:0045779)2.59289846
91cellular response to calcium ion (GO:0071277)2.58992771
92negative regulation of granulocyte differentiation (GO:0030853)2.58507134
93relaxation of smooth muscle (GO:0044557)2.56094402
94cofactor catabolic process (GO:0051187)2.55441611
95positive regulation of alpha-beta T cell differentiation (GO:0046638)2.54165812
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.54071299
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53546587
98positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.51142736
99antigen processing and presentation of endogenous antigen (GO:0019883)2.50647921
100nucleoside diphosphate biosynthetic process (GO:0009133)2.49615326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.80308687
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.82169321
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.09179480
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.50967474
5VDR_21846776_ChIP-Seq_THP-1_Human2.99587371
6VDR_24763502_ChIP-Seq_THP-1_Human2.85525579
7IGF1R_20145208_ChIP-Seq_DFB_Human2.74412231
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.68140983
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50068625
10SCL_19346495_ChIP-Seq_HPC-7_Human2.35838718
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20738132
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.12806867
13MYB_26560356_Chip-Seq_TH2_Human2.09829548
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07202414
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.02970540
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92495524
17SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.90656546
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89646487
19UTX_26944678_Chip-Seq_JUKART_Human1.88955817
20SPI1_23547873_ChIP-Seq_NB4_Human1.86432779
21RUNX_20019798_ChIP-Seq_JUKART_Human1.86403401
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.85127286
23GBX2_23144817_ChIP-Seq_PC3_Human1.85117393
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.84535337
25VDR_24787735_ChIP-Seq_THP-1_Human1.81973029
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80929264
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.69133719
28MYB_26560356_Chip-Seq_TH1_Human1.68488854
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66525918
30SPI1_23127762_ChIP-Seq_K562_Human1.61416832
31AR_21572438_ChIP-Seq_LNCaP_Human1.57231618
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56851372
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55596777
34MAF_26560356_Chip-Seq_TH2_Human1.51265131
35ELF1_20517297_ChIP-Seq_JURKAT_Human1.50124049
36GATA3_27048872_Chip-Seq_THYMUS_Human1.50031872
37GATA3_26560356_Chip-Seq_TH2_Human1.49898809
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43818427
39KDM2B_26808549_Chip-Seq_DND41_Human1.36933318
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35287876
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34042489
42SPI1_20517297_ChIP-Seq_HL60_Human1.32337554
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32233586
44ER_23166858_ChIP-Seq_MCF-7_Human1.27666253
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27285610
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26033094
47MAF_26560356_Chip-Seq_TH1_Human1.25134132
48ERA_21632823_ChIP-Seq_H3396_Human1.21447272
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.20149599
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15725296
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14128505
52CIITA_25753668_ChIP-Seq_RAJI_Human1.13953364
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.12561874
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.08403840
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07556179
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07489578
57RAC3_21632823_ChIP-Seq_H3396_Human1.07338076
58GATA1_22025678_ChIP-Seq_K562_Human1.05106459
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03819952
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02887701
61NANOG_20526341_ChIP-Seq_ESCs_Human1.02502503
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99716607
63ZNF274_21170338_ChIP-Seq_K562_Hela0.98516186
64NOTCH1_21737748_ChIP-Seq_TLL_Human0.97969905
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96939429
66CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96386717
67BCL6_27268052_Chip-Seq_Bcells_Human0.95914030
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94551904
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93584282
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92257923
71P300_27268052_Chip-Seq_Bcells_Human0.91502494
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89542630
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86497279
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86219943
75RXR_22108803_ChIP-Seq_LS180_Human0.83968114
76PHF8_20622854_ChIP-Seq_HELA_Human0.83863280
77KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83620474
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82657477
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82252678
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81872420
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.80298192
82STAT1_20625510_ChIP-Seq_HELA_Human0.80253502
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79039024
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78872759
85BCOR_27268052_Chip-Seq_Bcells_Human0.77458562
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77425551
87OCT4_20526341_ChIP-Seq_ESCs_Human0.76910467
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76872019
89LXR_22292898_ChIP-Seq_THP-1_Human0.76227235
90CTCF_21964334_Chip-Seq_Bcells_Human0.74685477
91E2F1_20622854_ChIP-Seq_HELA_Human0.74423335
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74071442
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72933619
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.72507157
95BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71865412
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.71859938
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71792691
98P68_20966046_ChIP-Seq_HELA_Human0.70247872
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.69584485
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67987360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH4.02440234
2MP0002132_abnormal_respiratory_system3.89287349
3MP0005058_abnormal_lysosome_morphology3.64719308
4MP0001835_abnormal_antigen_presentation3.35269164
5MP0003806_abnormal_nucleotide_metabolis2.99941185
6MP0003172_abnormal_lysosome_physiology2.85034269
7MP0003828_pulmonary_edema2.61210284
8MP0002009_preneoplasia2.53339887
9MP0000465_gastrointestinal_hemorrhage2.52679861
10MP0009697_abnormal_copulation2.37422787
11MP0003763_abnormal_thymus_physiology2.36232005
12MP0002419_abnormal_innate_immunity2.16919788
13MP0002166_altered_tumor_susceptibility2.13798412
14MP0005360_urolithiasis2.10799360
15MP0004084_abnormal_cardiac_muscle2.00900057
16MP0005646_abnormal_pituitary_gland1.92722617
17MP0003724_increased_susceptibility_to1.92274943
18MP0009840_abnormal_foam_cell1.89568175
19MP0003436_decreased_susceptibility_to1.82464251
20MP0006036_abnormal_mitochondrial_physio1.80344287
21MP0005397_hematopoietic_system_phenotyp1.74927800
22MP0001545_abnormal_hematopoietic_system1.74927800
23MP0002876_abnormal_thyroid_physiology1.71628322
24MP0009785_altered_susceptibility_to1.70368927
25MP0005025_abnormal_response_to1.63347683
26MP0002420_abnormal_adaptive_immunity1.63231197
27MP0001819_abnormal_immune_cell1.62275173
28MP0001800_abnormal_humoral_immune1.61904214
29MP0002160_abnormal_reproductive_system1.60832109
30MP0003315_abnormal_perineum_morphology1.57891378
31MP0009278_abnormal_bone_marrow1.56225903
32MP0010368_abnormal_lymphatic_system1.56022938
33MP0005671_abnormal_response_to1.51742299
34MP0002723_abnormal_immune_serum1.51004995
35MP0002452_abnormal_antigen_presenting1.50290923
36MP0005000_abnormal_immune_tolerance1.50204436
37MP0002127_abnormal_cardiovascular_syste1.49532682
38MP0004381_abnormal_hair_follicle1.48676405
39MP0002837_dystrophic_cardiac_calcinosis1.48093272
40MP0005464_abnormal_platelet_physiology1.45593952
41MP0000703_abnormal_thymus_morphology1.42281483
42MP0000681_abnormal_thyroid_gland1.39779872
43MP0002722_abnormal_immune_system1.38720725
44MP0002398_abnormal_bone_marrow1.33101686
45MP0004036_abnormal_muscle_relaxation1.33040571
46MP0005410_abnormal_fertilization1.30273739
47MP0005166_decreased_susceptibility_to1.29346320
48MP0002148_abnormal_hypersensitivity_rea1.28174266
49MP0000716_abnormal_immune_system1.28127632
50MP0000685_abnormal_immune_system1.26657070
51MP0001661_extended_life_span1.26062036
52MP0000749_muscle_degeneration1.25300868
53MP0002405_respiratory_system_inflammati1.24837948
54MP0001664_abnormal_digestion1.21950500
55MP0002998_abnormal_bone_remodeling1.19752533
56MP0000689_abnormal_spleen_morphology1.15851266
57MP0005645_abnormal_hypothalamus_physiol1.14722795
58MP0001984_abnormal_olfaction1.13835787
59MP0001501_abnormal_sleep_pattern1.11400217
60MP0001853_heart_inflammation1.11032070
61MP0002396_abnormal_hematopoietic_system1.08400171
62MP0005387_immune_system_phenotype1.08363523
63MP0001790_abnormal_immune_system1.08363523
64MP0005389_reproductive_system_phenotype1.05421141
65MP0004484_altered_response_of1.05237261
66MP0004808_abnormal_hematopoietic_stem1.03002924
67MP0001845_abnormal_inflammatory_respons1.02712497
68MP0010155_abnormal_intestine_physiology1.01676529
69MP0002006_tumorigenesis1.00559475
70MP0002429_abnormal_blood_cell0.98717949
71MP0004782_abnormal_surfactant_physiolog0.98506520
72MP0005330_cardiomyopathy0.96835698
73MP0000678_abnormal_parathyroid_gland0.96000296
74MP0001270_distended_abdomen0.93019634
75MP0003879_abnormal_hair_cell0.92567092
76MP0003300_gastrointestinal_ulcer0.91639284
77MP0005334_abnormal_fat_pad0.90980160
78MP0006072_abnormal_retinal_apoptosis0.89660829
79MP0002102_abnormal_ear_morphology0.89473322
80MP0003656_abnormal_erythrocyte_physiolo0.89180159
81MP0008469_abnormal_protein_level0.88469393
82MP0009250_abnormal_appendicular_skeleto0.87199354
83MP0002138_abnormal_hepatobiliary_system0.84308532
84MP0002269_muscular_atrophy0.83642093
85MP0005647_abnormal_sex_gland0.83402215
86MP0001905_abnormal_dopamine_level0.81308110
87MP0003252_abnormal_bile_duct0.79863960
88MP0001765_abnormal_ion_homeostasis0.78685984
89MP0009115_abnormal_fat_cell0.78496807
90MP0005319_abnormal_enzyme/_coenzyme0.78181041
91MP0006082_CNS_inflammation0.78092401
92MP0001533_abnormal_skeleton_physiology0.73057224
93MP0002933_joint_inflammation0.72393235
94MP0001849_ear_inflammation0.72232532
95MP0001919_abnormal_reproductive_system0.71576436
96MP0002108_abnormal_muscle_morphology0.68431197
97MP0008775_abnormal_heart_ventricle0.68389478
98MP0001764_abnormal_homeostasis0.68116846
99MP0002115_abnormal_skeleton_extremities0.66088513
100MP0005075_abnormal_melanosome_morpholog0.66072696

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the columella (HP:0009929)6.06733054
2Granulocytopenia (HP:0001913)4.81277962
3Acute lymphatic leukemia (HP:0006721)4.69186170
4Thoracic kyphosis (HP:0002942)4.65216038
5Eosinophilia (HP:0001880)4.54417109
6B lymphocytopenia (HP:0010976)4.52335957
7Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.48771614
8Abnormality of B cell number (HP:0010975)4.22892324
9Clumsiness (HP:0002312)4.17335044
10Reduced antithrombin III activity (HP:0001976)4.10764634
11Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.70218971
12Abnormality of eosinophils (HP:0001879)3.57261883
13Abnormality of the frontal sinuses (HP:0002687)3.47612522
14Severe combined immunodeficiency (HP:0004430)3.40963578
15Centrally nucleated skeletal muscle fibers (HP:0003687)3.19261945
16Recurrent cutaneous fungal infections (HP:0011370)3.19159081
17Chronic mucocutaneous candidiasis (HP:0002728)3.19159081
18Thrombocytosis (HP:0001894)3.01889452
19Elevated erythrocyte sedimentation rate (HP:0003565)3.01346940
20Abnormality of the thoracic spine (HP:0100711)2.98270972
21Recurrent fungal infections (HP:0002841)2.97151872
22Abnormality of the lumbar spine (HP:0100712)2.96060095
23Spinal cord lesions (HP:0100561)2.83496909
24Syringomyelia (HP:0003396)2.83496909
25Resting tremor (HP:0002322)2.82803157
26Leukocytosis (HP:0001974)2.81131859
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78628330
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78628330
29Stomatitis (HP:0010280)2.74940921
30Hyporeflexia of lower limbs (HP:0002600)2.66926845
31Recurrent viral infections (HP:0004429)2.64210538
32Thyroiditis (HP:0100646)2.62595736
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.57840160
34Myositis (HP:0100614)2.57097705
35Autoimmune thrombocytopenia (HP:0001973)2.56218644
36Spondylolisthesis (HP:0003302)2.55155068
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54860619
38Dysostosis multiplex (HP:0000943)2.54402131
39Panhypogammaglobulinemia (HP:0003139)2.53493525
40Colitis (HP:0002583)2.41081932
41Ventricular fibrillation (HP:0001663)2.38855866
42Abnormality of T cell physiology (HP:0011840)2.38255175
43Hypothermia (HP:0002045)2.36908110
44Combined immunodeficiency (HP:0005387)2.36316505
45Abnormality of DNA repair (HP:0003254)2.33720014
46Facial diplegia (HP:0001349)2.30949044
47Polygenic inheritance (HP:0010982)2.28027538
48Abnormality of the intrinsic pathway (HP:0010989)2.26075348
49EMG: myopathic abnormalities (HP:0003458)2.25246741
50Exercise-induced myalgia (HP:0003738)2.24657510
51Abnormality of T cells (HP:0002843)2.20156734
52Papilledema (HP:0001085)2.19610700
53Inflammation of the large intestine (HP:0002037)2.18520843
54Aplastic anemia (HP:0001915)2.16412471
55Sensory axonal neuropathy (HP:0003390)2.14103601
56Amyloidosis (HP:0011034)2.13588697
57Inability to walk (HP:0002540)2.10832833
58Abnormality of glycolipid metabolism (HP:0010969)2.07778513
59Abnormality of liposaccharide metabolism (HP:0010968)2.07778513
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.07778513
61Rhabdomyolysis (HP:0003201)2.07259049
62High anterior hairline (HP:0009890)2.05647182
63Abnormal rod and cone electroretinograms (HP:0008323)2.05376110
64Bile duct proliferation (HP:0001408)2.04147699
65Abnormal biliary tract physiology (HP:0012439)2.04147699
66Absent thumb (HP:0009777)2.02449440
67Abnormal ciliary motility (HP:0012262)2.00109841
68Abnormal protein glycosylation (HP:0012346)1.99927247
69Abnormal glycosylation (HP:0012345)1.99927247
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99927247
71Abnormal protein N-linked glycosylation (HP:0012347)1.99927247
72Gastrointestinal inflammation (HP:0004386)1.99110928
73High pitched voice (HP:0001620)1.98975889
74Autoimmune hemolytic anemia (HP:0001890)1.98915019
75Increased variability in muscle fiber diameter (HP:0003557)1.98740657
76Arterial thrombosis (HP:0004420)1.98045586
77Self-mutilation (HP:0000742)1.97175349
78Capillary hemangiomas (HP:0005306)1.94791170
79Facial hemangioma (HP:0000329)1.93713131
80Aortic aneurysm (HP:0004942)1.93461970
81Hemoptysis (HP:0002105)1.93036285
82Gastrointestinal infarctions (HP:0005244)1.92610414
83Increased density of long bones (HP:0006392)1.91227173
84Myoglobinuria (HP:0002913)1.90880232
85Abnormality of T cell number (HP:0011839)1.90550279
86Vacuolated lymphocytes (HP:0001922)1.89435976
87Gonadal dysgenesis (HP:0000133)1.89424239
88Premature loss of primary teeth (HP:0006323)1.88841170
89Prolonged bleeding time (HP:0003010)1.86138046
90Conical tooth (HP:0000698)1.85774642
91T lymphocytopenia (HP:0005403)1.84987157
92Vitreoretinal degeneration (HP:0000655)1.84494685
93Ketosis (HP:0001946)1.84444198
94Postural instability (HP:0002172)1.82993456
95Vasculitis (HP:0002633)1.82147165
96Petechiae (HP:0000967)1.81965960
97Abnormality of skeletal muscle fiber size (HP:0012084)1.79639494
98Abnormality of the prostate (HP:0008775)1.79229786
99Dynein arm defect of respiratory motile cilia (HP:0012255)1.79174392
100Absent/shortened dynein arms (HP:0200106)1.79174392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.17701313
2MARK33.89722784
3MAP3K133.01094765
4TAOK32.80207860
5NEK22.55690289
6FES2.54895986
7KIT2.38582575
8FLT32.37781291
9MYLK2.26272466
10LATS12.17418833
11MAP4K12.17022198
12EEF2K2.16199606
13OBSCN2.13532535
14MAP3K141.99136724
15GRK61.79045023
16BTK1.78043015
17TLK11.77312794
18MAP4K21.74168436
19FRK1.64263287
20TBK11.63208535
21ZAK1.58948195
22EIF2AK31.56276339
23MAP2K71.49982233
24ZAP701.49601365
25CSF1R1.41320301
26RIPK41.36403336
27PRKCQ1.35285761
28MAPK121.31807034
29BMPR21.27731576
30TIE11.26612119
31MAPK151.24024077
32CDK31.16465866
33BLK1.16032597
34SYK1.14383104
35IKBKE1.12334412
36PIK3CG1.09924996
37TRPM71.09515112
38RPS6KA41.05241524
39MAP3K11.01145437
40TEC1.00993276
41IKBKB1.00813922
42CSNK1A1L0.98606625
43MOS0.90483144
44NME20.89201390
45IRAK20.86810195
46MAPKAPK30.85273356
47BMPR1B0.83845172
48RPS6KB10.82412368
49PRKG20.78405389
50KDR0.78196173
51SGK2230.77340529
52SGK4940.77340529
53ITK0.77292855
54STK38L0.76155737
55TXK0.74892338
56MAP3K70.74477177
57STK380.73278155
58GRK10.72761363
59CSNK1G30.71465211
60MAP3K50.67913013
61MAP2K20.65285536
62PDK10.65193278
63PKN20.64566199
64PDPK10.63163549
65MAPK110.62816935
66LYN0.62000673
67TNK20.61376086
68CDK40.58321730
69HCK0.57995482
70PAK20.57506391
71RPS6KA50.55480063
72DYRK30.55277439
73RET0.52621361
74CDK80.52193841
75LCK0.51527532
76FGR0.48118750
77PTK2B0.45423967
78SGK20.45098698
79RPS6KA20.44697218
80EGFR0.43017991
81CCNB10.42841890
82PIK3CA0.41501987
83LATS20.41283689
84CDK120.41048988
85TGFBR10.40676180
86CSNK1G20.40448855
87RPS6KA10.40062122
88RPS6KB20.39292032
89CAMK10.38660951
90CDC42BPA0.38658226
91JAK10.38638556
92MAPK130.36963093
93CAMK40.34338616
94CSNK1G10.33856408
95DAPK30.33254456
96CDK60.32621005
97TRIB30.32465476
98ADRBK20.32404157
99TYK20.31370476
100MAP2K30.30677449

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.03951816
2Olfactory transduction_Homo sapiens_hsa047403.08191178
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.26679173
4Asthma_Homo sapiens_hsa053102.11372438
5Primary immunodeficiency_Homo sapiens_hsa053402.04914006
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.04348464
7Graft-versus-host disease_Homo sapiens_hsa053321.90051039
8B cell receptor signaling pathway_Homo sapiens_hsa046621.88060242
9Renin secretion_Homo sapiens_hsa049241.72749502
10Chemical carcinogenesis_Homo sapiens_hsa052041.71824469
11Nitrogen metabolism_Homo sapiens_hsa009101.71474361
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.69489598
13Staphylococcus aureus infection_Homo sapiens_hsa051501.68831152
14Allograft rejection_Homo sapiens_hsa053301.68093997
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65757085
16T cell receptor signaling pathway_Homo sapiens_hsa046601.60276615
17Autoimmune thyroid disease_Homo sapiens_hsa053201.58090149
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.57814117
19Systemic lupus erythematosus_Homo sapiens_hsa053221.50223261
20Oxytocin signaling pathway_Homo sapiens_hsa049211.48353116
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.44208792
22Leishmaniasis_Homo sapiens_hsa051401.43309183
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43047246
24Salivary secretion_Homo sapiens_hsa049701.41002484
25Acute myeloid leukemia_Homo sapiens_hsa052211.39576591
26Butanoate metabolism_Homo sapiens_hsa006501.38027510
27Herpes simplex infection_Homo sapiens_hsa051681.36193305
28Osteoclast differentiation_Homo sapiens_hsa043801.36039363
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35816629
30Platelet activation_Homo sapiens_hsa046111.35576395
31Type I diabetes mellitus_Homo sapiens_hsa049401.34671679
32Hematopoietic cell lineage_Homo sapiens_hsa046401.31285028
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28742546
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.24675265
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23062373
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22313891
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21873055
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19952242
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19907250
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19670770
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17462358
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12696791
43Regulation of autophagy_Homo sapiens_hsa041401.11504143
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11369320
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.11235679
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06902749
47Tuberculosis_Homo sapiens_hsa051521.05854801
48Pertussis_Homo sapiens_hsa051331.00608405
49Phototransduction_Homo sapiens_hsa047440.97720300
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94951022
51Apoptosis_Homo sapiens_hsa042100.92481629
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90468624
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88938431
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.87777638
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.84295543
56Malaria_Homo sapiens_hsa051440.84269058
57Arachidonic acid metabolism_Homo sapiens_hsa005900.79724312
58Phagosome_Homo sapiens_hsa041450.78536386
59Gastric acid secretion_Homo sapiens_hsa049710.77903372
60Antigen processing and presentation_Homo sapiens_hsa046120.77832792
61Circadian rhythm_Homo sapiens_hsa047100.76502238
62Influenza A_Homo sapiens_hsa051640.73103296
63Hepatitis B_Homo sapiens_hsa051610.67557196
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67427868
65Rheumatoid arthritis_Homo sapiens_hsa053230.66117728
66Pentose phosphate pathway_Homo sapiens_hsa000300.65912976
67Gap junction_Homo sapiens_hsa045400.65656033
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.64558611
69Legionellosis_Homo sapiens_hsa051340.64334501
70Circadian entrainment_Homo sapiens_hsa047130.62618732
71Measles_Homo sapiens_hsa051620.62072082
72Lysosome_Homo sapiens_hsa041420.61872056
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60393442
74Alcoholism_Homo sapiens_hsa050340.60339586
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59507285
76Dorso-ventral axis formation_Homo sapiens_hsa043200.57434561
77Glucagon signaling pathway_Homo sapiens_hsa049220.56333427
78Calcium signaling pathway_Homo sapiens_hsa040200.52389848
79MAPK signaling pathway_Homo sapiens_hsa040100.52189213
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51754865
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.50953791
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50944194
83Starch and sucrose metabolism_Homo sapiens_hsa005000.50875078
84Viral myocarditis_Homo sapiens_hsa054160.50837675
85Choline metabolism in cancer_Homo sapiens_hsa052310.49301393
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49207557
87Toxoplasmosis_Homo sapiens_hsa051450.48756087
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48139808
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47136223
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46961241
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45134947
92ABC transporters_Homo sapiens_hsa020100.44440902
93mTOR signaling pathway_Homo sapiens_hsa041500.44414138
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43729215
95Insulin resistance_Homo sapiens_hsa049310.42784719
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41999875
97Complement and coagulation cascades_Homo sapiens_hsa046100.41516215
98PPAR signaling pathway_Homo sapiens_hsa033200.40889088
99Selenocompound metabolism_Homo sapiens_hsa004500.40397893
100Dilated cardiomyopathy_Homo sapiens_hsa054140.39972298

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