GOLGA8N

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)6.68891217
2positive regulation of gamma-delta T cell activation (GO:0046645)6.27746029
3positive regulation of B cell differentiation (GO:0045579)5.33875310
4definitive hemopoiesis (GO:0060216)4.97830448
5regulation of gamma-delta T cell differentiation (GO:0045586)4.82105920
6positive regulation of granulocyte differentiation (GO:0030854)4.81601335
7response to peptidoglycan (GO:0032494)4.67919516
8cellular extravasation (GO:0045123)4.60180354
9response to muramyl dipeptide (GO:0032495)4.59841981
10regulation of gamma-delta T cell activation (GO:0046643)4.59535226
11poly(A)+ mRNA export from nucleus (GO:0016973)4.51994517
12B cell receptor signaling pathway (GO:0050853)4.48440826
13negative regulation of granulocyte differentiation (GO:0030853)4.39427773
14neutrophil activation involved in immune response (GO:0002283)4.38925937
15mannose metabolic process (GO:0006013)4.30070140
16regulation of B cell differentiation (GO:0045577)4.24384192
17regulation of B cell receptor signaling pathway (GO:0050855)4.22567994
18regulation of granulocyte differentiation (GO:0030852)4.05154359
19regulation of myeloid leukocyte mediated immunity (GO:0002886)3.74003531
20positive thymic T cell selection (GO:0045059)3.73767986
21regulation of leukocyte degranulation (GO:0043300)3.67042768
22negative thymic T cell selection (GO:0045060)3.65292875
23positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.64997065
24regulation of mast cell degranulation (GO:0043304)3.62116458
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55775518
26neutrophil mediated immunity (GO:0002446)3.55356465
27negative regulation of cell killing (GO:0031342)3.51436615
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.51436615
29negative regulation of interleukin-8 production (GO:0032717)3.40712811
30mature B cell differentiation involved in immune response (GO:0002313)3.38903978
31positive regulation by symbiont of host defense response (GO:0052509)3.38290674
32modulation by symbiont of host defense response (GO:0052031)3.38290674
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38290674
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38290674
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.38290674
36modulation by symbiont of host immune response (GO:0052553)3.38290674
37cell wall macromolecule catabolic process (GO:0016998)3.37942926
38megakaryocyte development (GO:0035855)3.36872263
39regulation of mast cell activation involved in immune response (GO:0033006)3.36469679
40negative T cell selection (GO:0043383)3.34867874
41negative regulation of T cell mediated immunity (GO:0002710)3.31081026
42antigen processing and presentation of endogenous antigen (GO:0019883)3.27190752
43macrophage activation involved in immune response (GO:0002281)3.18924318
44germinal center formation (GO:0002467)3.18665966
45microglial cell activation (GO:0001774)3.17336153
46Peyers patch development (GO:0048541)3.15429516
47mucosal-associated lymphoid tissue development (GO:0048537)3.15429516
48myeloid cell activation involved in immune response (GO:0002275)3.13836627
49T cell migration (GO:0072678)3.12124839
50regulation of regulated secretory pathway (GO:1903305)3.07800593
51histone H3-K36 demethylation (GO:0070544)3.05985270
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05911500
53leukocyte degranulation (GO:0043299)3.05088081
54regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.04820541
55detection of other organism (GO:0098543)3.02007393
56negative regulation of lymphocyte mediated immunity (GO:0002707)2.99097416
57regulation of erythrocyte differentiation (GO:0045646)2.98675779
58positive T cell selection (GO:0043368)2.97638095
59neutrophil activation (GO:0042119)2.94156926
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93552217
61activated T cell proliferation (GO:0050798)2.93132498
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93090096
63regulation of hypersensitivity (GO:0002883)2.91925987
64positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.90626208
65regulation of mast cell activation (GO:0033003)2.90110586
66detection of bacterium (GO:0016045)2.88658789
67T cell selection (GO:0045058)2.88216610
68negative regulation of interleukin-6 production (GO:0032715)2.87188293
69myeloid leukocyte mediated immunity (GO:0002444)2.84761070
70immunoglobulin mediated immune response (GO:0016064)2.83485436
71mature B cell differentiation (GO:0002335)2.80151778
72cell wall macromolecule metabolic process (GO:0044036)2.79506674
73Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79037569
74response to protozoan (GO:0001562)2.78421192
75negative regulation of leukocyte mediated immunity (GO:0002704)2.77300087
76macrophage activation (GO:0042116)2.76753329
77cellular response to exogenous dsRNA (GO:0071360)2.74778571
78negative regulation of interleukin-12 production (GO:0032695)2.73577828
79positive regulation of mast cell degranulation (GO:0043306)2.73180932
80positive regulation of mast cell activation involved in immune response (GO:0033008)2.73180932
81leukocyte aggregation (GO:0070486)2.70219336
82thymic T cell selection (GO:0045061)2.69743123
83G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.69585893
84regulation of female gonad development (GO:2000194)2.69201976
85histone H3-K4 trimethylation (GO:0080182)2.67699853
86positive regulation of alpha-beta T cell differentiation (GO:0046638)2.67071704
87positive regulation of mast cell activation (GO:0033005)2.67041895
88interkinetic nuclear migration (GO:0022027)2.66504192
89pinocytosis (GO:0006907)2.66346083
90B cell homeostasis (GO:0001782)2.66341024
91positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.66127401
92modulation of growth of symbiont involved in interaction with host (GO:0044144)2.65450175
93regulation of growth of symbiont in host (GO:0044126)2.65450175
94negative regulation of growth of symbiont in host (GO:0044130)2.65450175
95negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.65450175
96dosage compensation (GO:0007549)2.63165394
97negative regulation of bone resorption (GO:0045779)2.62226077
98positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62142622
99histone H3-K9 modification (GO:0061647)2.61608422
100macrophage differentiation (GO:0030225)2.61239375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.97389002
2VDR_21846776_ChIP-Seq_THP-1_Human4.50392448
3SCL_19346495_ChIP-Seq_HPC-7_Human4.07016423
4VDR_24763502_ChIP-Seq_THP-1_Human4.01822276
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.80015378
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.63372524
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.51511130
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.22617566
9RUNX_20019798_ChIP-Seq_JUKART_Human2.86561651
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86070317
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81875547
12MYB_26560356_Chip-Seq_TH2_Human2.78256806
13MYC_22102868_ChIP-Seq_BL_Human2.70419563
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64696995
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.61948365
16SPI1_23547873_ChIP-Seq_NB4_Human2.47173652
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.46439721
18VDR_24787735_ChIP-Seq_THP-1_Human2.39996437
19SPI1_23127762_ChIP-Seq_K562_Human2.37263035
20TCF7_22412390_ChIP-Seq_EML_Mouse2.34954181
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34527245
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33787607
23MYB_26560356_Chip-Seq_TH1_Human2.29703212
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20163073
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16315122
26UTX_26944678_Chip-Seq_JUKART_Human2.15783160
27MAF_26560356_Chip-Seq_TH1_Human2.13897711
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.11801927
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.06948936
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05604492
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01367817
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.95452969
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.93862237
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93025980
35KDM2B_26808549_Chip-Seq_DND41_Human1.89350043
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88911518
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88775318
38SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.84931315
39GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.83063860
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77388799
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.71256204
42GATA3_27048872_Chip-Seq_THYMUS_Human1.70834738
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67617551
44MAF_26560356_Chip-Seq_TH2_Human1.62130656
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61876098
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59219765
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55684763
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55134648
49GATA1_19941826_ChIP-Seq_K562_Human1.54084594
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52840454
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52414560
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49091042
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45073312
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43764747
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43199894
56GATA1_22025678_ChIP-Seq_K562_Human1.40229438
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40040326
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39275417
59GATA2_19941826_ChIP-Seq_K562_Human1.39018109
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37074728
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33547286
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.31305327
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31083585
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28372774
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28185663
66GATA3_26560356_Chip-Seq_TH2_Human1.27964254
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27490248
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23377138
69CIITA_25753668_ChIP-Seq_RAJI_Human1.18710041
70PU_27001747_Chip-Seq_BMDM_Mouse1.17149086
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15404346
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13411976
73RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11865024
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07978236
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07176214
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06371084
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06023891
78DROSHA_22980978_ChIP-Seq_HELA_Human1.05220298
79GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04831257
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.02025526
81LXR_22292898_ChIP-Seq_THP-1_Human1.01077601
82NCOR1_26117541_ChIP-Seq_K562_Human0.99213931
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98262465
84ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95522720
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95089065
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94996040
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.93854913
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90786492
89BCOR_27268052_Chip-Seq_Bcells_Human0.90032818
90SPI1_20517297_ChIP-Seq_HL60_Human0.89179225
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89144260
92SMRT_27268052_Chip-Seq_Bcells_Human0.82765112
93BCL6_27268052_Chip-Seq_Bcells_Human0.81921645
94P300_27268052_Chip-Seq_Bcells_Human0.81471607
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.79434864
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79356521
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75684921
98SMAD_19615063_ChIP-ChIP_OVARY_Human0.75624183
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74885523
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74349596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.97153795
2MP0001835_abnormal_antigen_presentation3.59562440
3MP0003172_abnormal_lysosome_physiology3.30319048
4MP0003436_decreased_susceptibility_to3.01073296
5MP0003303_peritoneal_inflammation2.82444823
6MP0005464_abnormal_platelet_physiology2.80107383
7MP0002009_preneoplasia2.78692189
8MP0002419_abnormal_innate_immunity2.64261475
9MP0004808_abnormal_hematopoietic_stem2.63523204
10MP0003763_abnormal_thymus_physiology2.62936328
11MP0005397_hematopoietic_system_phenotyp2.60964356
12MP0001545_abnormal_hematopoietic_system2.60964356
13MP0009278_abnormal_bone_marrow2.55898769
14MP0003724_increased_susceptibility_to2.29103211
15MP0001800_abnormal_humoral_immune2.26923268
16MP0005025_abnormal_response_to2.22682107
17MP0005058_abnormal_lysosome_morphology2.19312751
18MP0002420_abnormal_adaptive_immunity2.09675174
19MP0001819_abnormal_immune_cell2.06147261
20MP0002723_abnormal_immune_serum2.00475590
21MP0005000_abnormal_immune_tolerance1.99778997
22MP0002398_abnormal_bone_marrow1.99049453
23MP0002166_altered_tumor_susceptibility1.95641404
24MP0003828_pulmonary_edema1.95364099
25MP0002452_abnormal_antigen_presenting1.92063734
26MP0003300_gastrointestinal_ulcer1.90422453
27MP0006082_CNS_inflammation1.82510559
28MP0000716_abnormal_immune_system1.74715803
29MP0002722_abnormal_immune_system1.72517503
30MP0000689_abnormal_spleen_morphology1.71038712
31MP0000685_abnormal_immune_system1.69862843
32MP0003656_abnormal_erythrocyte_physiolo1.68443547
33MP0002405_respiratory_system_inflammati1.66808184
34MP0000569_abnormal_digit_pigmentation1.65606768
35MP0000703_abnormal_thymus_morphology1.64779831
36MP0000465_gastrointestinal_hemorrhage1.61383757
37MP0001790_abnormal_immune_system1.57882911
38MP0005387_immune_system_phenotype1.57882911
39MP0005671_abnormal_response_to1.54640272
40MP0005666_abnormal_adipose_tissue1.54582465
41MP0002148_abnormal_hypersensitivity_rea1.48589128
42MP0008057_abnormal_DNA_replication1.47746774
43MP0001851_eye_inflammation1.45636060
44MP0002429_abnormal_blood_cell1.45498648
45MP0010155_abnormal_intestine_physiology1.44693713
46MP0009785_altered_susceptibility_to1.43027496
47MP0004130_abnormal_muscle_cell1.38699762
48MP0004185_abnormal_adipocyte_glucose1.35923240
49MP0001533_abnormal_skeleton_physiology1.31354473
50MP0003183_abnormal_peptide_metabolism1.29650479
51MP0000015_abnormal_ear_pigmentation1.27975599
52MP0004947_skin_inflammation1.23965618
53MP0002132_abnormal_respiratory_system1.23934021
54MP0001845_abnormal_inflammatory_respons1.23418911
55MP0001853_heart_inflammation1.20987645
56MP0005174_abnormal_tail_pigmentation1.19986223
57MP0005075_abnormal_melanosome_morpholog1.18678831
58MP0003866_abnormal_defecation1.18117850
59MP0002006_tumorigenesis1.10899400
60MP0003191_abnormal_cellular_cholesterol1.10048176
61MP0009333_abnormal_splenocyte_physiolog1.08828615
62MP0005410_abnormal_fertilization1.08552355
63MP0002998_abnormal_bone_remodeling1.07632112
64MP0008469_abnormal_protein_level1.07389551
65MP0001986_abnormal_taste_sensitivity1.06157774
66MP0000681_abnormal_thyroid_gland1.04493274
67MP0004381_abnormal_hair_follicle1.00681287
68MP0005670_abnormal_white_adipose0.99190785
69MP0009115_abnormal_fat_cell0.95307121
70MP0004484_altered_response_of0.95237183
71MP0008004_abnormal_stomach_pH0.94512835
72MP0002971_abnormal_brown_adipose0.92729193
73MP0005535_abnormal_body_temperature0.91878809
74MP0005375_adipose_tissue_phenotype0.88330373
75MP0005409_darkened_coat_color0.82291122
76MP0009764_decreased_sensitivity_to0.82239881
77MP0005076_abnormal_cell_differentiation0.79385741
78MP0000604_amyloidosis0.78468618
79MP0003045_fibrosis0.77672873
80MP0003690_abnormal_glial_cell0.77018180
81MP0001765_abnormal_ion_homeostasis0.76397895
82MP0005220_abnormal_exocrine_pancreas0.75956808
83MP0008961_abnormal_basal_metabolism0.75625880
84MP0004883_abnormal_blood_vessel0.74907666
85MP0000249_abnormal_blood_vessel0.74398130
86MP0005166_decreased_susceptibility_to0.74227223
87MP0008007_abnormal_cellular_replicative0.73817307
88MP0005164_abnormal_response_to0.72098092
89MP0002933_joint_inflammation0.71079195
90MP0005334_abnormal_fat_pad0.70548859
91MP0001873_stomach_inflammation0.69991964
92MP0004036_abnormal_muscle_relaxation0.67637592
93MP0002019_abnormal_tumor_incidence0.66808356
94MP0005310_abnormal_salivary_gland0.65588338
95MP0005451_abnormal_body_composition0.63729424
96MP0008260_abnormal_autophagy0.61870139
97MP0002138_abnormal_hepatobiliary_system0.60651324
98MP0009763_increased_sensitivity_to0.59806362
99MP0005390_skeleton_phenotype0.59514134
100MP0010307_abnormal_tumor_latency0.59218133

Predicted human phenotypes

RankGene SetZ-score
1Acute lymphatic leukemia (HP:0006721)5.11008201
2Recurrent abscess formation (HP:0002722)4.40069501
3Acute myeloid leukemia (HP:0004808)4.39798630
4Recurrent bacterial skin infections (HP:0005406)4.13978100
5Elevated erythrocyte sedimentation rate (HP:0003565)4.12869292
6Prolonged bleeding time (HP:0003010)4.09521978
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.86494919
8Recurrent cutaneous fungal infections (HP:0011370)3.78591031
9Chronic mucocutaneous candidiasis (HP:0002728)3.78591031
10Myositis (HP:0100614)3.71610958
11Recurrent fungal infections (HP:0002841)3.69873130
12Thrombocytosis (HP:0001894)3.60753259
13Panhypogammaglobulinemia (HP:0003139)3.51015298
14Eczematoid dermatitis (HP:0000976)3.41517498
15Stomatitis (HP:0010280)3.38315169
16Recurrent viral infections (HP:0004429)3.28336177
17Epistaxis (HP:0000421)3.24313953
18Recurrent skin infections (HP:0001581)3.23128374
19Spontaneous hematomas (HP:0007420)3.22369700
20Agammaglobulinemia (HP:0004432)3.16894021
21Meningitis (HP:0001287)3.16163640
22Inflammation of the large intestine (HP:0002037)3.12535022
23Abnormality of B cell number (HP:0010975)3.10444574
24Increased IgE level (HP:0003212)3.04984853
25Granulocytopenia (HP:0001913)3.04631554
26Colitis (HP:0002583)3.03746159
27Gastrointestinal inflammation (HP:0004386)3.03618631
28Spondylolisthesis (HP:0003302)3.00077944
29B lymphocytopenia (HP:0010976)2.97605129
30Chest pain (HP:0100749)2.97043269
31Gingival bleeding (HP:0000225)2.92353950
32Papilledema (HP:0001085)2.91339534
33Chronic obstructive pulmonary disease (HP:0006510)2.90702593
34Obstructive lung disease (HP:0006536)2.90702593
35Gastrointestinal infarctions (HP:0005244)2.85376885
36Abnormality of T cell physiology (HP:0011840)2.80065309
37Gingivitis (HP:0000230)2.74124352
38Dysostosis multiplex (HP:0000943)2.73672066
39Cellulitis (HP:0100658)2.72316376
40Abnormality of macrophages (HP:0004311)2.71563187
41Encephalitis (HP:0002383)2.68778053
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.61781574
43Thoracic kyphosis (HP:0002942)2.61599475
44Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.60176823
45Amyloidosis (HP:0011034)2.58940608
46Recurrent gram-negative bacterial infections (HP:0005420)2.58842555
47Mediastinal lymphadenopathy (HP:0100721)2.58098365
48Abnormality of the fingertips (HP:0001211)2.54833055
49Increased cerebral lipofuscin (HP:0011813)2.43027584
50Petechiae (HP:0000967)2.41693703
51Abnormality of T cells (HP:0002843)2.41259295
52Arterial thrombosis (HP:0004420)2.40045372
53Abnormality of the prostate (HP:0008775)2.39873039
54Vasculitis (HP:0002633)2.39613944
55Orchitis (HP:0100796)2.37328411
56Hemoptysis (HP:0002105)2.36445494
57Autoimmune thrombocytopenia (HP:0001973)2.35732802
58Fatigue (HP:0012378)2.31720263
59Leukocytosis (HP:0001974)2.30284131
60Viral hepatitis (HP:0006562)2.26264906
61Autoimmune hemolytic anemia (HP:0001890)2.23910845
62Abnormal platelet function (HP:0011869)2.21979304
63Impaired platelet aggregation (HP:0003540)2.21979304
64Retrobulbar optic neuritis (HP:0100654)2.20808689
65Optic neuritis (HP:0100653)2.20808689
66Osteomyelitis (HP:0002754)2.18670257
67Polygenic inheritance (HP:0010982)2.18590653
68Asymmetric septal hypertrophy (HP:0001670)2.15772804
69Pustule (HP:0200039)2.11989475
70Abnormality of the thoracic spine (HP:0100711)2.11514007
71Thickened calvaria (HP:0002684)2.08230293
72Episodic fever (HP:0001954)2.07458075
73Hypochromic anemia (HP:0001931)2.06031937
74Pulmonary embolism (HP:0002204)2.05349675
75Abnormality of the lumbar spine (HP:0100712)1.93885616
76Aplasia/Hypoplasia of the thymus (HP:0010515)1.93721457
77T lymphocytopenia (HP:0005403)1.90836956
78Urticaria (HP:0001025)1.88110259
79Pulmonary infiltrates (HP:0002113)1.87732332
80Keratoconjunctivitis sicca (HP:0001097)1.87091146
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86897558
82Eosinophilia (HP:0001880)1.85468623
83Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85035764
84Severe combined immunodeficiency (HP:0004430)1.84535178
85Mucopolysacchariduria (HP:0008155)1.84418473
86Urinary glycosaminoglycan excretion (HP:0003541)1.84418473
87Abnormality of T cell number (HP:0011839)1.83861305
88Severe visual impairment (HP:0001141)1.82923755
89Interstitial pulmonary disease (HP:0006530)1.81364366
90Neurodegeneration (HP:0002180)1.81246637
91Periodontitis (HP:0000704)1.79602793
92Abnormality of polysaccharide metabolism (HP:0011012)1.79232925
93Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79232925
94Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79232925
95Ocular albinism (HP:0001107)1.78363307
96Hypoplasia of the thymus (HP:0000778)1.77682542
97Hypochromic microcytic anemia (HP:0004840)1.75462715
98Dysmetric saccades (HP:0000641)1.74945641
99Syringomyelia (HP:0003396)1.73624963
100Spinal cord lesions (HP:0100561)1.73624963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.78349220
2KIT3.39678853
3FES2.97572085
4PRPF4B2.67538830
5TEC2.56309262
6MAP3K132.50603479
7MAP2K32.48623629
8FLT32.40803143
9MAP4K12.36646349
10BTK2.26098302
11MAP3K142.15711961
12TAOK32.13311545
13ZAP702.02870549
14EEF2K2.00673164
15SYK1.96754742
16TNK21.95386890
17PIK3CG1.77998280
18BLK1.75451920
19CDK121.74634046
20CSF1R1.72872038
21ITK1.70147236
22TYK21.68117270
23TRIB31.66135452
24CDK61.62523195
25GRK61.57035996
26MAP3K61.49092026
27TRPM71.48172899
28TBK11.43702162
29BRD41.40507551
30TXK1.40439344
31HCK1.39228108
32ERN11.34663177
33JAK31.27543614
34BMPR21.21873481
35MAP3K71.20024495
36MAPK121.18121549
37LYN1.18002061
38JAK11.11631728
39PKN21.11258252
40MAPK71.05260625
41LCK1.04583240
42PDK11.02909607
43IKBKE1.01285104
44IRAK41.00544076
45HIPK20.99654876
46JAK20.98801675
47CDK40.98461952
48CSK0.94620346
49IKBKB0.93956804
50MAP2K60.92793505
51MARK20.90442880
52PDPK10.87120095
53MAP3K10.84625708
54MARK30.74016740
55RPS6KB20.72522255
56NEK90.72077487
57RET0.72055538
58MAPK150.70936747
59MAP2K20.70632296
60PRKCQ0.70374222
61FGFR30.69979753
62MATK0.68546580
63MAPK110.68244955
64RPS6KC10.68099171
65RPS6KL10.68099171
66TTN0.65721936
67WNK10.62280581
68CAMK1G0.62209440
69CDK30.61348036
70RPS6KA60.60544639
71PRKAA20.60360052
72PLK40.59923593
73FRK0.59009699
74RPS6KA40.58004165
75KSR20.57764630
76MAPK40.54863001
77YES10.54760300
78MAPK30.49379588
79SIK20.46466889
80PASK0.44264015
81PIM10.41466460
82IRAK10.41223056
83MAP2K40.40328592
84DAPK20.38516004
85STK110.37844443
86CAMK1D0.37804397
87STK100.36916190
88MTOR0.36738709
89RPS6KA20.35998524
90LRRK20.34233822
91TGFBR20.33521442
92MAP3K20.32717486
93MOS0.32110703
94ABL10.31931740
95MAPK10.31360084
96SGK10.30956723
97FYN0.28880271
98IRAK20.28660549
99SGK30.28486915
100RPS6KA10.26688119

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.92841094
2B cell receptor signaling pathway_Homo sapiens_hsa046622.59991083
3Acute myeloid leukemia_Homo sapiens_hsa052212.57081237
4Leishmaniasis_Homo sapiens_hsa051402.43064968
5Osteoclast differentiation_Homo sapiens_hsa043802.20359278
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.05102443
7Platelet activation_Homo sapiens_hsa046111.75539203
8Dorso-ventral axis formation_Homo sapiens_hsa043201.69998498
9Graft-versus-host disease_Homo sapiens_hsa053321.69686935
10Staphylococcus aureus infection_Homo sapiens_hsa051501.67997872
11Asthma_Homo sapiens_hsa053101.66538977
12T cell receptor signaling pathway_Homo sapiens_hsa046601.63341452
13Allograft rejection_Homo sapiens_hsa053301.61689241
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59488258
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58938600
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58365921
17Hematopoietic cell lineage_Homo sapiens_hsa046401.52029102
18Non-small cell lung cancer_Homo sapiens_hsa052231.49126872
19Autoimmune thyroid disease_Homo sapiens_hsa053201.46753768
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45149468
21Tuberculosis_Homo sapiens_hsa051521.44002399
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.42146801
23Influenza A_Homo sapiens_hsa051641.41639161
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41271252
25Chronic myeloid leukemia_Homo sapiens_hsa052201.40395513
26Type I diabetes mellitus_Homo sapiens_hsa049401.37827343
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.36695694
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31311904
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.29797827
30Primary immunodeficiency_Homo sapiens_hsa053401.29765829
31Toxoplasmosis_Homo sapiens_hsa051451.27587299
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.26737562
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24032060
34Pancreatic cancer_Homo sapiens_hsa052121.19878711
35VEGF signaling pathway_Homo sapiens_hsa043701.16234727
36Measles_Homo sapiens_hsa051621.14488196
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14038038
38Hepatitis B_Homo sapiens_hsa051611.11714745
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11392698
40mTOR signaling pathway_Homo sapiens_hsa041501.09764042
41Antigen processing and presentation_Homo sapiens_hsa046121.09515202
42Herpes simplex infection_Homo sapiens_hsa051681.09033013
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.05417629
44Malaria_Homo sapiens_hsa051441.05270996
45Prolactin signaling pathway_Homo sapiens_hsa049171.03951643
46Chemokine signaling pathway_Homo sapiens_hsa040621.03794789
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01873180
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00255681
49Inositol phosphate metabolism_Homo sapiens_hsa005621.00226278
50TNF signaling pathway_Homo sapiens_hsa046680.99947401
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97644883
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.97219080
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.95848789
54Choline metabolism in cancer_Homo sapiens_hsa052310.95377315
55GnRH signaling pathway_Homo sapiens_hsa049120.95040240
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92544300
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90566772
58Insulin resistance_Homo sapiens_hsa049310.90556087
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.88290014
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.88279127
61African trypanosomiasis_Homo sapiens_hsa051430.86951974
62Type II diabetes mellitus_Homo sapiens_hsa049300.86244543
63Legionellosis_Homo sapiens_hsa051340.84412288
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.84408129
65Viral myocarditis_Homo sapiens_hsa054160.81029658
66Renal cell carcinoma_Homo sapiens_hsa052110.78548491
67Renin secretion_Homo sapiens_hsa049240.76533561
68Pancreatic secretion_Homo sapiens_hsa049720.73351745
69Long-term potentiation_Homo sapiens_hsa047200.73012622
70Systemic lupus erythematosus_Homo sapiens_hsa053220.70216698
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69842711
72Pertussis_Homo sapiens_hsa051330.69107135
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.68654061
74FoxO signaling pathway_Homo sapiens_hsa040680.65840628
75Amoebiasis_Homo sapiens_hsa051460.65672960
76Lysosome_Homo sapiens_hsa041420.65149128
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63595322
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63370671
79Oxytocin signaling pathway_Homo sapiens_hsa049210.63261063
80Viral carcinogenesis_Homo sapiens_hsa052030.62856715
81MAPK signaling pathway_Homo sapiens_hsa040100.62694514
82Hepatitis C_Homo sapiens_hsa051600.62474685
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60540268
84Salivary secretion_Homo sapiens_hsa049700.59488407
85Estrogen signaling pathway_Homo sapiens_hsa049150.59244763
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.56001134
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55697391
88HTLV-I infection_Homo sapiens_hsa051660.54264180
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54061775
90Glioma_Homo sapiens_hsa052140.52689282
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52629014
92Renin-angiotensin system_Homo sapiens_hsa046140.50088775
93Colorectal cancer_Homo sapiens_hsa052100.48561938
94Lysine degradation_Homo sapiens_hsa003100.48301284
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46151290
96Rheumatoid arthritis_Homo sapiens_hsa053230.46038773
97ErbB signaling pathway_Homo sapiens_hsa040120.45606261
98Calcium signaling pathway_Homo sapiens_hsa040200.45214290
99Notch signaling pathway_Homo sapiens_hsa043300.44439632
100Apoptosis_Homo sapiens_hsa042100.42813941

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