GOLGA8O

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.01455261
2response to pheromone (GO:0019236)8.58941046
3plasma membrane fusion (GO:0045026)7.98143811
4protein targeting to Golgi (GO:0000042)7.88796016
5chromosome condensation (GO:0030261)7.68608120
6DNA packaging (GO:0006323)7.55676227
7establishment of protein localization to Golgi (GO:0072600)7.54930297
8retrograde transport, vesicle recycling within Golgi (GO:0000301)7.43392732
9spermatid development (GO:0007286)7.36769508
10single strand break repair (GO:0000012)7.18935432
11microtubule depolymerization (GO:0007019)7.09935041
12multicellular organism reproduction (GO:0032504)7.04686692
13phosphatidylethanolamine biosynthetic process (GO:0006646)7.02735719
14protein polyglutamylation (GO:0018095)6.80695300
15sperm-egg recognition (GO:0035036)6.71251492
16phosphatidylethanolamine metabolic process (GO:0046337)6.47678690
17reproduction (GO:0000003)6.39154694
18spermatid nucleus differentiation (GO:0007289)6.38494789
19calcium ion-dependent exocytosis (GO:0017156)6.15944629
20microtubule polymerization or depolymerization (GO:0031109)6.11381494
21negative regulation of inclusion body assembly (GO:0090084)6.03901036
22rRNA methylation (GO:0031167)6.03339182
23axonemal dynein complex assembly (GO:0070286)5.89440624
24protein localization to Golgi apparatus (GO:0034067)5.85630764
25cell wall macromolecule catabolic process (GO:0016998)5.81060011
26centriole replication (GO:0007099)5.78891487
27regulation of Rab GTPase activity (GO:0032313)5.67835704
28positive regulation of Rab GTPase activity (GO:0032851)5.67835704
29spermatogenesis (GO:0007283)5.67695981
30cell wall macromolecule metabolic process (GO:0044036)5.65727544
31male gamete generation (GO:0048232)5.65403788
32binding of sperm to zona pellucida (GO:0007339)5.65249789
33cell-cell recognition (GO:0009988)5.63563904
34sexual reproduction (GO:0019953)5.53314762
35microtubule severing (GO:0051013)5.43924080
36gamete generation (GO:0007276)5.17275745
37regulation of cilium movement (GO:0003352)5.10043585
38regulation of transcription involved in cell fate commitment (GO:0060850)5.09005273
39cellular ketone body metabolic process (GO:0046950)5.08441333
40RNA destabilization (GO:0050779)5.08339966
41seminiferous tubule development (GO:0072520)5.00887090
42centriole assembly (GO:0098534)5.00792433
43cilium or flagellum-dependent cell motility (GO:0001539)4.99483032
44rRNA modification (GO:0000154)4.85674645
45single fertilization (GO:0007338)4.71041401
46regulation of centriole replication (GO:0046599)4.47456163
47ketone body metabolic process (GO:1902224)4.45378330
48regulation of T-helper 2 cell differentiation (GO:0045628)4.45161796
49motile cilium assembly (GO:0044458)4.40484303
50germ cell development (GO:0007281)4.28050530
51regulation of inclusion body assembly (GO:0090083)4.15684139
52multicellular organismal reproductive process (GO:0048609)4.13475860
53response to acidic pH (GO:0010447)4.08091891
54cellular process involved in reproduction in multicellular organism (GO:0022412)4.06460956
55chromatin silencing (GO:0006342)4.03395362
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.02067097
57fertilization (GO:0009566)4.00477059
58epithelial cilium movement (GO:0003351)3.95524947
59regulation of interleukin-13 production (GO:0032656)3.76293767
60multicellular organismal movement (GO:0050879)3.72675400
61musculoskeletal movement (GO:0050881)3.72675400
62peptidyl-threonine dephosphorylation (GO:0035970)3.71090820
63homeostasis of number of cells within a tissue (GO:0048873)3.53337324
64cilium movement (GO:0003341)3.53147951
65nucleus organization (GO:0006997)3.47739338
66organic cation transport (GO:0015695)3.46711298
67regulation of microtubule-based movement (GO:0060632)3.42932270
68Golgi to endosome transport (GO:0006895)3.42739954
69receptor recycling (GO:0001881)3.32691940
70microtubule nucleation (GO:0007020)3.32346670
71cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.24127427
72coenzyme catabolic process (GO:0009109)3.23613538
73membrane protein intracellular domain proteolysis (GO:0031293)3.22752251
74intra-Golgi vesicle-mediated transport (GO:0006891)3.18916412
75cerebral cortex neuron differentiation (GO:0021895)3.09704842
76positive regulation of type 2 immune response (GO:0002830)3.06015229
77regulation of phosphoprotein phosphatase activity (GO:0043666)3.05506863
78epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04190633
79positive regulation of interleukin-4 production (GO:0032753)2.96771446
80mast cell activation involved in immune response (GO:0002279)2.94627816
81mast cell degranulation (GO:0043303)2.94627816
82cellular response to pH (GO:0071467)2.93964233
83negative regulation of granulocyte differentiation (GO:0030853)2.93692743
84multicellular organismal development (GO:0007275)2.91470124
85glycerol ether metabolic process (GO:0006662)2.88286662
86histone H3-K9 demethylation (GO:0033169)2.87431596
87positive regulation of T cell cytokine production (GO:0002726)2.81799215
88negative regulation of gene expression, epigenetic (GO:0045814)2.79025417
89peptide catabolic process (GO:0043171)2.78642052
90positive regulation of guanylate cyclase activity (GO:0031284)2.76071213
91negative regulation of histone methylation (GO:0031061)2.73197784
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.70097205
93regulation of guanylate cyclase activity (GO:0031282)2.69170819
94regulation of ARF GTPase activity (GO:0032312)2.68686659
95positive regulation of T-helper cell differentiation (GO:0045624)2.67598609
96ether metabolic process (GO:0018904)2.67476068
97cranial nerve morphogenesis (GO:0021602)2.65721644
98sperm motility (GO:0030317)11.3916381
99acrosome reaction (GO:0007340)10.6806896
100fusion of sperm to egg plasma membrane (GO:0007342)10.5335777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.82928464
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.27609305
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.17642003
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.05041834
5EZH2_22144423_ChIP-Seq_EOC_Human2.78666083
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.35423882
7ELF1_20517297_ChIP-Seq_JURKAT_Human2.24186345
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.21174753
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21174753
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.05107466
11CBP_20019798_ChIP-Seq_JUKART_Human2.05107466
12DROSHA_22980978_ChIP-Seq_HELA_Human2.01267970
13EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.96614858
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95863104
15ERA_21632823_ChIP-Seq_H3396_Human1.95519574
16RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.91893514
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88991899
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87543895
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85537966
20RAC3_21632823_ChIP-Seq_H3396_Human1.81620667
21BCL6_27268052_Chip-Seq_Bcells_Human1.80124528
22NANOG_20526341_ChIP-Seq_ESCs_Human1.74270603
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.70539580
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.68454821
25RUNX_20019798_ChIP-Seq_JUKART_Human1.67728321
26BCOR_27268052_Chip-Seq_Bcells_Human1.66767873
27EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.66060953
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62045828
29MYC_19829295_ChIP-Seq_ESCs_Human1.60330996
30ER_23166858_ChIP-Seq_MCF-7_Human1.59190078
31P300_27268052_Chip-Seq_Bcells_Human1.57365448
32PHF8_20622854_ChIP-Seq_HELA_Human1.57069988
33P68_20966046_ChIP-Seq_HELA_Human1.56991464
34SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56825989
35E2F1_20622854_ChIP-Seq_HELA_Human1.54608073
36CTCF_27219007_Chip-Seq_Bcells_Human1.53833767
37AR_21572438_ChIP-Seq_LNCaP_Human1.51727355
38OCT4_20526341_ChIP-Seq_ESCs_Human1.51338298
39ERG_20517297_ChIP-Seq_VCAP_Human1.51172870
40FUS_26573619_Chip-Seq_HEK293_Human1.50923800
41TAF2_19829295_ChIP-Seq_ESCs_Human1.47232188
42CTCF_20526341_ChIP-Seq_ESCs_Human1.44733238
43SMC4_20622854_ChIP-Seq_HELA_Human1.42407917
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40461903
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.39389635
46ZNF274_21170338_ChIP-Seq_K562_Hela1.37758339
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36865311
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.36443476
49TDRD3_21172665_ChIP-Seq_MCF-7_Human1.36309796
50AR_25329375_ChIP-Seq_VCAP_Human1.35459327
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35106957
52PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33714227
53CEBPB_22108803_ChIP-Seq_LS180_Human1.33543415
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32587568
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.31853815
56TP63_22573176_ChIP-Seq_HFKS_Human1.30864535
57P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.29945825
58HNFA_21074721_ChIP-Seq_CACO-2_Human1.27284532
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.25023015
60RBPJ_21746931_ChIP-Seq_IB4_Human1.24056650
61CBX2_22325352_ChIP-Seq_293T-Rex_Human1.23825362
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23169997
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23051119
64SMRT_27268052_Chip-Seq_Bcells_Human1.22205683
65LXR_22292898_ChIP-Seq_THP-1_Human1.21015680
66ETV1_20927104_ChIP-Seq_GIST48_Human1.20421542
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18439756
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18400712
69SMAD3_21741376_ChIP-Seq_ESCs_Human1.17934933
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17864677
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16860652
72P53_21459846_ChIP-Seq_SAOS-2_Human1.14400195
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.14397084
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14052024
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14044189
76KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.11980078
77SPI1_20517297_ChIP-Seq_HL60_Human1.11926907
78STAT1_20625510_ChIP-Seq_HELA_Human1.10229392
79TAF15_26573619_Chip-Seq_HEK293_Human1.10223775
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08410571
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07809132
82SOX2_22085726_ChIP-Seq_NPCs_Mouse1.07684476
83NFYB_21822215_ChIP-Seq_K562_Human1.06760526
84RUNX2_22187159_ChIP-Seq_PCA_Human1.06551277
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05830903
86TP53_18474530_ChIP-ChIP_U2OS_Human1.05526777
87P300_19829295_ChIP-Seq_ESCs_Human1.05427044
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.05355408
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03996657
90GATA6_21074721_ChIP-Seq_CACO-2_Human1.02020967
91TBL1_22424771_ChIP-Seq_293T_Human1.01914998
92FOXH1_21741376_ChIP-Seq_ESCs_Human1.00961005
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.00439182
94VDR_24787735_ChIP-Seq_THP-1_Human0.97873485
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97689492
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.97519993
97PHF8_20622853_ChIP-Seq_HELA_Human0.97374726
98SA1_27219007_Chip-Seq_Bcells_Human0.97360538
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.97179970
100NANOG_19829295_ChIP-Seq_ESCs_Human0.96518954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology5.27438779
2MP0005377_hearing/vestibular/ear_phenot5.27438779
3MP0005670_abnormal_white_adipose4.60052752
4MP0003698_abnormal_male_reproductive3.97261577
5MP0001929_abnormal_gametogenesis3.49042330
6MP0001348_abnormal_lacrimal_gland3.17109748
7MP0002132_abnormal_respiratory_system2.37031455
8MP0000678_abnormal_parathyroid_gland2.34729504
9MP0005379_endocrine/exocrine_gland_phen2.24826043
10MP0002161_abnormal_fertility/fecundity2.15234382
11MP0005410_abnormal_fertilization11.0746296
12MP0002822_catalepsy1.97998655
13MP0003646_muscle_fatigue1.81748537
14MP0003718_maternal_effect1.75946323
15MP0001485_abnormal_pinna_reflex1.72493834
16MP0003011_delayed_dark_adaptation1.66335522
17MP0001765_abnormal_ion_homeostasis1.56972824
18MP0001486_abnormal_startle_reflex1.52343197
19MP0002210_abnormal_sex_determination1.49195149
20MP0002127_abnormal_cardiovascular_syste1.36102963
21MP0005310_abnormal_salivary_gland1.34227353
22MP0003879_abnormal_hair_cell1.31164630
23MP0001968_abnormal_touch/_nociception1.29745702
24MP0002249_abnormal_larynx_morphology1.26942577
25MP0004742_abnormal_vestibular_system1.26537217
26MP0001835_abnormal_antigen_presentation1.23117706
27MP0005423_abnormal_somatic_nervous1.19086554
28MP0002282_abnormal_trachea_morphology1.17944912
29MP0000653_abnormal_sex_gland1.16674801
30MP0005451_abnormal_body_composition1.16658913
31MP0001145_abnormal_male_reproductive1.16227016
32MP0009697_abnormal_copulation1.12691756
33MP0009115_abnormal_fat_cell1.07874282
34MP0001905_abnormal_dopamine_level1.06778691
35MP0003172_abnormal_lysosome_physiology1.05548608
36MP0001963_abnormal_hearing_physiology1.05018896
37MP0005666_abnormal_adipose_tissue0.94995874
38MP0002928_abnormal_bile_duct0.94068462
39MP0002138_abnormal_hepatobiliary_system0.92714277
40MP0005551_abnormal_eye_electrophysiolog0.90825976
41MP0002229_neurodegeneration0.90429453
42MP0002735_abnormal_chemical_nociception0.88806780
43MP0000681_abnormal_thyroid_gland0.88771978
44MP0005636_abnormal_mineral_homeostasis0.87468220
45MP0008961_abnormal_basal_metabolism0.87389194
46MP0001501_abnormal_sleep_pattern0.86750211
47MP0000026_abnormal_inner_ear0.86401432
48MP0004859_abnormal_synaptic_plasticity0.84662690
49MP0004510_myositis0.83141483
50MP0008877_abnormal_DNA_methylation0.82542493
51MP0009764_decreased_sensitivity_to0.82200573
52MP0001270_distended_abdomen0.82122029
53MP0005084_abnormal_gallbladder_morpholo0.81145719
54MP0005397_hematopoietic_system_phenotyp0.79868666
55MP0001545_abnormal_hematopoietic_system0.79868666
56MP0008995_early_reproductive_senescence0.79300671
57MP0010329_abnormal_lipoprotein_level0.75926863
58MP0005645_abnormal_hypothalamus_physiol0.74366835
59MP0005535_abnormal_body_temperature0.73656294
60MP0002234_abnormal_pharynx_morphology0.73229123
61MP0008569_lethality_at_weaning0.70847546
62MP0001727_abnormal_embryo_implantation0.70208193
63MP0002557_abnormal_social/conspecific_i0.70158604
64MP0002067_abnormal_sensory_capabilities0.70027082
65MP0004233_abnormal_muscle_weight0.69880557
66MP0005253_abnormal_eye_physiology0.68937571
67MP0001666_abnormal_nutrient_absorption0.67152005
68MP0002733_abnormal_thermal_nociception0.65212663
69MP0000534_abnormal_ureter_morphology0.64905053
70MP0005671_abnormal_response_to0.64713471
71MP0005375_adipose_tissue_phenotype0.62266054
72MP0002572_abnormal_emotion/affect_behav0.62136798
73MP0005464_abnormal_platelet_physiology0.61200545
74MP0009053_abnormal_anal_canal0.61184741
75MP0000955_abnormal_spinal_cord0.60121581
76MP0001440_abnormal_grooming_behavior0.59775049
77MP0004484_altered_response_of0.58312696
78MP0005395_other_phenotype0.57648329
79MP0000015_abnormal_ear_pigmentation0.55100452
80MP0000703_abnormal_thymus_morphology0.54770489
81MP0000249_abnormal_blood_vessel0.53470713
82MP0003252_abnormal_bile_duct0.52452246
83MP0005647_abnormal_sex_gland0.52337369
84MP0002723_abnormal_immune_serum0.51907005
85MP0009745_abnormal_behavioral_response0.51893801
86MP0003787_abnormal_imprinting0.49705079
87MP0002722_abnormal_immune_system0.49607772
88MP0005000_abnormal_immune_tolerance0.49441264
89MP0003638_abnormal_response/metabolism_0.49147523
90MP0005167_abnormal_blood-brain_barrier0.48144230
91MP0009765_abnormal_xenobiotic_induced0.47890287
92MP0002163_abnormal_gland_morphology0.47707512
93MP0002971_abnormal_brown_adipose0.47634290
94MP0008004_abnormal_stomach_pH0.46467670
95MP0003436_decreased_susceptibility_to0.46437765
96MP0001533_abnormal_skeleton_physiology0.46080074
97MP0000685_abnormal_immune_system0.46069412
98MP0000470_abnormal_stomach_morphology0.45511352
99MP0002419_abnormal_innate_immunity0.45121496
100MP0005408_hypopigmentation0.44118742

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.41215667
2Absent/shortened dynein arms (HP:0200106)5.80331584
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.80331584
4Asymmetric septal hypertrophy (HP:0001670)5.27881200
5Bony spicule pigmentary retinopathy (HP:0007737)4.92218563
6Attenuation of retinal blood vessels (HP:0007843)4.90216911
7Tubulointerstitial nephritis (HP:0001970)4.85344007
8Facial shape deformation (HP:0011334)4.65152921
9Potter facies (HP:0002009)4.65152921
10Abnormal ciliary motility (HP:0012262)4.47362200
11Abnormal respiratory motile cilium physiology (HP:0012261)4.32725830
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.25463022
13Resting tremor (HP:0002322)4.18948384
14Enlarged epiphyses (HP:0010580)4.17715634
15Bell-shaped thorax (HP:0001591)4.16900213
16Abnormal respiratory epithelium morphology (HP:0012253)4.15323549
17Abnormal respiratory motile cilium morphology (HP:0005938)4.15323549
18Hyperkalemia (HP:0002153)4.05128364
19Chronic hepatic failure (HP:0100626)4.04292289
20Abnormal rod and cone electroretinograms (HP:0008323)4.04108904
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.91822235
22Male infertility (HP:0003251)3.84967384
23Hypoplasia of the thymus (HP:0000778)3.81523857
24Cone-rod dystrophy (HP:0000548)3.80954039
25Infertility (HP:0000789)3.77871659
26Nasal polyposis (HP:0100582)3.64302365
27Abnormality of macular pigmentation (HP:0008002)3.49954112
28Impulsivity (HP:0100710)3.44136044
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.43620166
30Hypoplastic ischia (HP:0003175)3.29698223
31Abnormality of the costochondral junction (HP:0000919)3.22096129
32Abnormal spermatogenesis (HP:0008669)3.16387724
33Nephronophthisis (HP:0000090)3.03850138
34Azoospermia (HP:0000027)2.99967277
35Rhinitis (HP:0012384)2.99201943
36Abnormality of the nasal mucosa (HP:0000433)2.95726697
37Abnormality of the ischium (HP:0003174)2.85490690
38Postural instability (HP:0002172)2.78328580
39Abnormality of dental color (HP:0011073)2.71446270
40Abnormal urine output (HP:0012590)2.70703254
41Progressive cerebellar ataxia (HP:0002073)2.70659013
42Truncal obesity (HP:0001956)2.69847424
43Epiphyseal dysplasia (HP:0002656)2.69023068
44Generalized aminoaciduria (HP:0002909)2.67382458
45Abnormality of the renal medulla (HP:0100957)2.65526731
46Progressive sensorineural hearing impairment (HP:0000408)2.65180337
47Polydipsia (HP:0001959)2.64703124
48Abnormal drinking behavior (HP:0030082)2.64703124
49Portal hypertension (HP:0001409)2.57943334
50Tubulointerstitial abnormality (HP:0001969)2.47778790
51Hypoalphalipoproteinemia (HP:0003233)2.45419895
52Menstrual irregularities (HP:0000858)2.44122422
53Abnormality of renal excretion (HP:0011036)2.41701602
54Amelogenesis imperfecta (HP:0000705)2.37827445
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.36652604
56Stage 5 chronic kidney disease (HP:0003774)2.34876304
57Abnormality of the hepatic vasculature (HP:0006707)2.34594512
58Widely patent fontanelles and sutures (HP:0004492)2.29807737
59Renovascular hypertension (HP:0100817)2.29311683
60Abnormality of potassium homeostasis (HP:0011042)2.27543072
61Insulin-resistant diabetes mellitus (HP:0000831)2.27150443
62Polyuria (HP:0000103)2.26326651
63B lymphocytopenia (HP:0010976)2.24284496
64Bronchiectasis (HP:0002110)2.21391575
65Abnormality of B cell number (HP:0010975)2.13762831
66Abnormality of the aortic arch (HP:0012303)2.02742262
67Aplasia/Hypoplasia of the thymus (HP:0010515)2.01768819
68Recurrent pneumonia (HP:0006532)1.99881587
69Congenital malformation of the right heart (HP:0011723)1.97004989
70Double outlet right ventricle (HP:0001719)1.97004989
71Hypophosphatemic rickets (HP:0004912)1.96522993
72Gastrointestinal infarctions (HP:0005244)1.96266031
73Protuberant abdomen (HP:0001538)1.95957683
74Renal Fanconi syndrome (HP:0001994)1.92200606
75Abnormality of the epiphysis of the femoral head (HP:0010574)1.91313548
76Abnormality of the femoral head (HP:0003368)1.89000681
77Muscle fiber atrophy (HP:0100295)1.88396189
78Severe combined immunodeficiency (HP:0004430)1.87386741
79Tubular atrophy (HP:0000092)1.86015507
80Hyperthyroidism (HP:0000836)1.83323759
81Decreased central vision (HP:0007663)1.82939207
82Chronic bronchitis (HP:0004469)1.81537074
83Renal dysplasia (HP:0000110)1.81286559
84Progressive hearing impairment (HP:0001730)1.79113668
85Photophobia (HP:0000613)1.76569745
86Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.75761004
87Abnormality of femoral epiphyses (HP:0006499)1.75761004
88Type 2 muscle fiber atrophy (HP:0003554)1.75101045
89Congenital sensorineural hearing impairment (HP:0008527)1.70951864
90Thyroiditis (HP:0100646)1.70717316
91Tetany (HP:0001281)1.67949472
92Abnormality of the renal cortex (HP:0011035)1.67001442
93Fatigable weakness (HP:0003473)1.66723703
94Abnormality of the neuromuscular junction (HP:0003398)1.66723703
95Spastic paraparesis (HP:0002313)1.66605718
96Abnormality of urine glucose concentration (HP:0011016)1.66290520
97Glycosuria (HP:0003076)1.66290520
98Abnormality of the pubic bones (HP:0003172)1.65631959
99Hypergonadotropic hypogonadism (HP:0000815)1.65104876
100Intellectual disability, moderate (HP:0002342)1.64294760

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.07708205
2TESK14.77025810
3DDR24.38111835
4MAP4K23.56815549
5INSRR3.50976693
6STK383.02065568
7PLK22.91827294
8MAPK152.84104188
9BRD42.77744289
10PRKD32.74281728
11PNCK2.70657360
12CAMK1G2.13270825
13STK38L2.12016430
14PIK3CG1.99749594
15MST1R1.44782680
16PDK11.40323746
17NEK61.35117802
18PDPK11.33310556
19CDK121.32100937
20FES1.27932450
21TAOK31.25574070
22PTK2B1.09050593
23WNK11.08450166
24DYRK1B1.03863888
25KIT1.03103427
26RPS6KA21.03004289
27SIK20.99077422
28RIPK40.96914851
29WNK40.92629437
30CDK70.89451102
31TYRO30.83720724
32MAP2K20.82588402
33CSF1R0.74901922
34FRK0.73822629
35STK390.73527495
36MAPK110.73489023
37TXK0.71908494
38GRK60.69487710
39CAMK1D0.69344328
40PRKG10.69225433
41SYK0.69158532
42EEF2K0.67609408
43CDK40.66633498
44CAMK10.66187009
45TEC0.65850128
46JAK30.64901079
47RPS6KA10.61646236
48BMPR20.61146949
49AKT30.59954561
50CDK30.57358433
51MAP4K10.56417214
52OXSR10.55568062
53PRKG20.55147486
54KSR20.52416818
55PRKAA20.51964840
56RPS6KL10.50912053
57RPS6KC10.50912053
58BLK0.50049780
59FLT30.49303078
60PRKCQ0.48724611
61RPS6KA60.47388937
62ITK0.47134460
63TIE10.46625768
64GSK3B0.45903892
65TLK10.44297913
66ROCK10.43599466
67MAPK10.42830547
68CDK20.42244874
69ADRBK20.41863660
70SGK2230.41021126
71SGK4940.41021126
72TESK20.40825657
73CAMK40.40311887
74IKBKB0.39836225
75PINK10.39725219
76MAP3K110.37878218
77CDK10.37380199
78TNK20.36956648
79MAPK80.36291694
80MAP3K20.34954043
81PRKCB0.33669910
82BTK0.32324825
83BRAF0.31209670
84NEK20.30746920
85CASK0.30673208
86CHEK10.30552965
87UHMK10.29451834
88NTRK30.29010663
89MAP3K10.28778867
90MAPK140.27044609
91MTOR0.26033099
92SGK10.25818055
93JAK20.25499929
94MAPK100.25422005
95PRKCH0.24544746
96PRKCZ0.24452009
97TNIK0.23613794
98LCK0.22589622
99SGK30.22090868
100MAPK130.21192584

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.66906038
2Fatty acid biosynthesis_Homo sapiens_hsa000615.01163970
3Olfactory transduction_Homo sapiens_hsa047403.71517913
4Glycerophospholipid metabolism_Homo sapiens_hsa005642.34457826
5Butanoate metabolism_Homo sapiens_hsa006502.26927632
6Dorso-ventral axis formation_Homo sapiens_hsa043202.03544494
7Selenocompound metabolism_Homo sapiens_hsa004502.02246756
8Graft-versus-host disease_Homo sapiens_hsa053322.01035856
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.80748947
10Type I diabetes mellitus_Homo sapiens_hsa049401.76589290
11Antigen processing and presentation_Homo sapiens_hsa046121.73327884
12Allograft rejection_Homo sapiens_hsa053301.66165133
13Autoimmune thyroid disease_Homo sapiens_hsa053201.63748992
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63570719
15Taste transduction_Homo sapiens_hsa047421.49916319
16Phototransduction_Homo sapiens_hsa047441.44477190
17Primary immunodeficiency_Homo sapiens_hsa053401.31943346
18Type II diabetes mellitus_Homo sapiens_hsa049301.27201751
19Adipocytokine signaling pathway_Homo sapiens_hsa049201.26807713
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25380224
21RNA transport_Homo sapiens_hsa030131.19255496
22Circadian entrainment_Homo sapiens_hsa047131.19247958
23Morphine addiction_Homo sapiens_hsa050321.19040393
24Salivary secretion_Homo sapiens_hsa049701.18190994
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10532553
26Fatty acid degradation_Homo sapiens_hsa000711.07588067
27Inositol phosphate metabolism_Homo sapiens_hsa005621.04226338
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.03192185
29B cell receptor signaling pathway_Homo sapiens_hsa046620.98399195
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96129504
31Renin secretion_Homo sapiens_hsa049240.95394678
32Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89904029
33Endocytosis_Homo sapiens_hsa041440.88994486
34Calcium signaling pathway_Homo sapiens_hsa040200.88339112
35Gastric acid secretion_Homo sapiens_hsa049710.87833652
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85442875
37Viral myocarditis_Homo sapiens_hsa054160.84875161
38Fatty acid metabolism_Homo sapiens_hsa012120.84723203
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84519920
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84181785
41Nitrogen metabolism_Homo sapiens_hsa009100.84169293
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.83966648
43cAMP signaling pathway_Homo sapiens_hsa040240.83554918
44Acute myeloid leukemia_Homo sapiens_hsa052210.82892382
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82484978
46Glycerolipid metabolism_Homo sapiens_hsa005610.82115802
47Glutamatergic synapse_Homo sapiens_hsa047240.80807915
48Phenylalanine metabolism_Homo sapiens_hsa003600.80026401
49Influenza A_Homo sapiens_hsa051640.79957638
50Protein digestion and absorption_Homo sapiens_hsa049740.79728267
51Estrogen signaling pathway_Homo sapiens_hsa049150.78430957
52Synaptic vesicle cycle_Homo sapiens_hsa047210.78298778
53Renin-angiotensin system_Homo sapiens_hsa046140.77576715
54Cholinergic synapse_Homo sapiens_hsa047250.76821469
55Oocyte meiosis_Homo sapiens_hsa041140.75252860
56Serotonergic synapse_Homo sapiens_hsa047260.74757584
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.73039255
58GABAergic synapse_Homo sapiens_hsa047270.68374037
59Platelet activation_Homo sapiens_hsa046110.67687086
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67303623
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64350557
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63155684
63Cardiac muscle contraction_Homo sapiens_hsa042600.62453852
64ABC transporters_Homo sapiens_hsa020100.61421984
65T cell receptor signaling pathway_Homo sapiens_hsa046600.60088168
66Nicotine addiction_Homo sapiens_hsa050330.60009225
67Oxytocin signaling pathway_Homo sapiens_hsa049210.59583833
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56970315
69Insulin secretion_Homo sapiens_hsa049110.56896022
70Osteoclast differentiation_Homo sapiens_hsa043800.56656291
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55924573
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53772646
73Fat digestion and absorption_Homo sapiens_hsa049750.53503640
74Purine metabolism_Homo sapiens_hsa002300.52269020
75MAPK signaling pathway_Homo sapiens_hsa040100.51864697
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51611681
77Hedgehog signaling pathway_Homo sapiens_hsa043400.50947427
78Arginine biosynthesis_Homo sapiens_hsa002200.50840077
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50560059
80Chemokine signaling pathway_Homo sapiens_hsa040620.48531975
81Regulation of autophagy_Homo sapiens_hsa041400.46944448
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.44086044
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.44085271
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42916177
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42325162
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42098651
87Cocaine addiction_Homo sapiens_hsa050300.41794034
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.41792698
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41628744
90Hematopoietic cell lineage_Homo sapiens_hsa046400.41337111
91Pancreatic secretion_Homo sapiens_hsa049720.41033154
92PPAR signaling pathway_Homo sapiens_hsa033200.40231731
93Herpes simplex infection_Homo sapiens_hsa051680.39971708
94Toxoplasmosis_Homo sapiens_hsa051450.39416021
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38994915
96Sulfur relay system_Homo sapiens_hsa041220.38672557
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.38425311
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38211186
99Leishmaniasis_Homo sapiens_hsa051400.36956693
100VEGF signaling pathway_Homo sapiens_hsa043700.36830447

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