GOLGA8Q

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.31521169
2cellular extravasation (GO:0045123)5.20643169
3positive regulation of B cell differentiation (GO:0045579)5.20439847
4response to muramyl dipeptide (GO:0032495)5.13482480
5negative regulation of erythrocyte differentiation (GO:0045647)5.10772395
6cell wall macromolecule catabolic process (GO:0016998)5.00436644
7poly(A)+ mRNA export from nucleus (GO:0016973)4.80327256
8positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.43088110
9histone H3-K36 demethylation (GO:0070544)4.26435667
10neutrophil mediated immunity (GO:0002446)4.21291265
11regulation of B cell receptor signaling pathway (GO:0050855)4.20115585
12neutrophil activation involved in immune response (GO:0002283)4.18090180
13response to peptidoglycan (GO:0032494)4.17686832
14negative regulation of interleukin-8 production (GO:0032717)4.16558956
15positive regulation of granulocyte differentiation (GO:0030854)4.12750317
16cell wall macromolecule metabolic process (GO:0044036)4.11778056
17regulation of B cell differentiation (GO:0045577)4.08914417
18sperm motility (GO:0030317)4.07761727
19regulation of gamma-delta T cell differentiation (GO:0045586)4.04880095
20regulation of myeloid leukocyte mediated immunity (GO:0002886)3.98816016
21regulation of mast cell degranulation (GO:0043304)3.95368813
22regulation of gamma-delta T cell activation (GO:0046643)3.90416510
23regulation of leukocyte degranulation (GO:0043300)3.87428025
24B cell receptor signaling pathway (GO:0050853)3.83999102
25negative regulation of granulocyte differentiation (GO:0030853)3.67577755
26regulation of mast cell activation involved in immune response (GO:0033006)3.66300418
27acrosome reaction (GO:0007340)3.60865925
28regulation of granulocyte differentiation (GO:0030852)3.57289059
29spermatid nucleus differentiation (GO:0007289)3.56523640
30positive regulation of mast cell degranulation (GO:0043306)3.53232400
31positive regulation of mast cell activation involved in immune response (GO:0033008)3.53232400
32negative regulation of T cell mediated immunity (GO:0002710)3.51419488
33regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.49364631
34negative thymic T cell selection (GO:0045060)3.48096333
35positive regulation of mast cell activation (GO:0033005)3.46047951
36cilium or flagellum-dependent cell motility (GO:0001539)3.45704264
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35659765
38cellular response to exogenous dsRNA (GO:0071360)3.33449970
39definitive hemopoiesis (GO:0060216)3.28265271
40negative T cell selection (GO:0043383)3.26540022
41RNA destabilization (GO:0050779)3.25116621
42regulation of mast cell activation (GO:0033003)3.24833517
43fusion of sperm to egg plasma membrane (GO:0007342)3.23385088
44leukocyte degranulation (GO:0043299)3.14968515
45Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14671134
46myeloid leukocyte mediated immunity (GO:0002444)3.14196926
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.13537660
48modulation by symbiont of host immune response (GO:0052553)3.13537660
49positive regulation by symbiont of host defense response (GO:0052509)3.13537660
50modulation by symbiont of host defense response (GO:0052031)3.13537660
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13537660
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13537660
53dosage compensation (GO:0007549)3.11125184
54megakaryocyte development (GO:0035855)3.10611230
55regulation of regulated secretory pathway (GO:1903305)3.10083386
56histone H4 deacetylation (GO:0070933)3.05391157
57neutrophil activation (GO:0042119)3.01118654
58T cell migration (GO:0072678)3.00865136
59histone H3-K9 methylation (GO:0051567)2.99771959
60myeloid cell activation involved in immune response (GO:0002275)2.99386993
61regulation of ARF GTPase activity (GO:0032312)2.90911205
62DNA packaging (GO:0006323)2.89707213
63microglial cell activation (GO:0001774)2.89441252
64retrograde transport, vesicle recycling within Golgi (GO:0000301)2.89142361
65mannose metabolic process (GO:0006013)2.87771690
66negative regulation of growth of symbiont in host (GO:0044130)2.87026873
67negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.87026873
68modulation of growth of symbiont involved in interaction with host (GO:0044144)2.87026873
69regulation of growth of symbiont in host (GO:0044126)2.87026873
70histamine secretion (GO:0001821)2.86479667
71chromosome condensation (GO:0030261)2.85947174
72establishment of protein localization to Golgi (GO:0072600)2.85509221
73histone H3-K9 modification (GO:0061647)2.85216386
74natural killer cell activation involved in immune response (GO:0002323)2.85151250
75positive thymic T cell selection (GO:0045059)2.85113002
76peptidyl-threonine dephosphorylation (GO:0035970)2.83814422
77protein targeting to Golgi (GO:0000042)2.83556461
78phosphatidylethanolamine biosynthetic process (GO:0006646)2.83056368
79macrophage activation involved in immune response (GO:0002281)2.82195917
80mast cell activation involved in immune response (GO:0002279)2.80305358
81mast cell degranulation (GO:0043303)2.80305358
82histone lysine demethylation (GO:0070076)2.78139529
83regulation of Rab GTPase activity (GO:0032313)2.77534043
84positive regulation of Rab GTPase activity (GO:0032851)2.77534043
85response to protozoan (GO:0001562)2.76436920
86cellular response to ethanol (GO:0071361)2.75602410
87negative regulation of interleukin-6 production (GO:0032715)2.75244544
88histone demethylation (GO:0016577)2.74792144
89positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.74673372
90positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.71941233
91sperm capacitation (GO:0048240)2.71609101
92response to pheromone (GO:0019236)2.70995448
93single strand break repair (GO:0000012)2.70981316
94histone H3-K4 trimethylation (GO:0080182)2.66638456
95chromatin silencing (GO:0006342)2.66443316
96spermatid development (GO:0007286)2.65771246
97regulation of interleukin-8 biosynthetic process (GO:0045414)2.65260907
98actin nucleation (GO:0045010)2.64787148
99negative regulation of lymphocyte mediated immunity (GO:0002707)2.64385503
100receptor recycling (GO:0001881)2.63670352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.12358926
2VDR_21846776_ChIP-Seq_THP-1_Human4.01460622
3SCL_19346495_ChIP-Seq_HPC-7_Human3.96333569
4VDR_24763502_ChIP-Seq_THP-1_Human3.61626180
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.51958678
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24569224
7RUNX_20019798_ChIP-Seq_JUKART_Human3.03241234
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.79641956
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.70377311
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.60454894
11MYB_26560356_Chip-Seq_TH2_Human2.50120532
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.39990333
13SPI1_23127762_ChIP-Seq_K562_Human2.39085885
14VDR_24787735_ChIP-Seq_THP-1_Human2.35912694
15MYC_22102868_ChIP-Seq_BL_Human2.34577238
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26267510
17SPI1_23547873_ChIP-Seq_NB4_Human2.22866849
18SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.22263245
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16984997
20UTX_26944678_Chip-Seq_JUKART_Human2.16276153
21GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.14088930
22TCF7_22412390_ChIP-Seq_EML_Mouse2.08934627
23RUNX1_22412390_ChIP-Seq_EML_Mouse1.99644559
24MAF_26560356_Chip-Seq_TH1_Human1.97795109
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.95179265
26MYB_26560356_Chip-Seq_TH1_Human1.93830485
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91759843
28GATA1_19941826_ChIP-Seq_K562_Human1.88133521
29GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.87945231
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87503789
31VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.86747102
32GATA1_19941827_ChIP-Seq_MEL_Mouse1.86128903
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85524852
34DROSHA_22980978_ChIP-Seq_HELA_Human1.84298058
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84200947
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84077635
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75755246
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75009774
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74074034
40KDM2B_26808549_Chip-Seq_DND41_Human1.73589827
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.71301177
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69300558
43GATA3_27048872_Chip-Seq_THYMUS_Human1.69192381
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.69113785
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.68351370
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67576146
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61039452
48MAF_26560356_Chip-Seq_TH2_Human1.60162840
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59681316
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58753360
51BCL6_27268052_Chip-Seq_Bcells_Human1.56135253
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52010017
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49860135
54GATA2_19941826_ChIP-Seq_K562_Human1.47268383
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39731353
56LXR_22292898_ChIP-Seq_THP-1_Human1.37932036
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35279974
58GATA3_26560356_Chip-Seq_TH2_Human1.34986230
59BCOR_27268052_Chip-Seq_Bcells_Human1.33125431
60CIITA_25753668_ChIP-Seq_RAJI_Human1.32500918
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28554419
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28155339
63P68_20966046_ChIP-Seq_HELA_Human1.26755209
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25570535
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23906960
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23656860
67RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23014698
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20913147
69P300_27268052_Chip-Seq_Bcells_Human1.20892717
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19875437
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19045864
72E2F1_20622854_ChIP-Seq_HELA_Human1.18385447
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17347069
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14336134
75SPI1_20517297_ChIP-Seq_HL60_Human1.13393419
76PU_27001747_Chip-Seq_BMDM_Mouse1.13242060
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12517823
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12123583
79PHF8_20622854_ChIP-Seq_HELA_Human1.11375870
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10918313
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09894045
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09718190
83RAC3_21632823_ChIP-Seq_H3396_Human1.03330525
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03165308
85KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.02514986
86SMC4_20622854_ChIP-Seq_HELA_Human1.02296577
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01650174
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01133175
89NCOR1_26117541_ChIP-Seq_K562_Human1.00019798
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99689221
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98465439
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.98148606
93GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98023812
94GATA1_22025678_ChIP-Seq_K562_Human0.97933625
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.96130409
96KDM2B_26808549_Chip-Seq_JURKAT_Human0.92816669
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92546832
98SMRT_27268052_Chip-Seq_Bcells_Human0.92357183
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91195513
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91119323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.04046040
2MP0003172_abnormal_lysosome_physiology3.83208810
3MP0005464_abnormal_platelet_physiology3.52108089
4MP0002396_abnormal_hematopoietic_system3.46856298
5MP0001835_abnormal_antigen_presentation3.30540301
6MP0003436_decreased_susceptibility_to3.20723434
7MP0000465_gastrointestinal_hemorrhage2.98108693
8MP0002419_abnormal_innate_immunity2.73386129
9MP0005058_abnormal_lysosome_morphology2.59308987
10MP0000569_abnormal_digit_pigmentation2.54273182
11MP0001545_abnormal_hematopoietic_system2.38266584
12MP0005397_hematopoietic_system_phenotyp2.38266584
13MP0003303_peritoneal_inflammation2.37089015
14MP0009278_abnormal_bone_marrow2.33204981
15MP0005025_abnormal_response_to2.19602811
16MP0002009_preneoplasia2.14669418
17MP0001800_abnormal_humoral_immune2.12205616
18MP0003724_increased_susceptibility_to2.06535279
19MP0004808_abnormal_hematopoietic_stem2.03941979
20MP0002420_abnormal_adaptive_immunity1.99282245
21MP0003828_pulmonary_edema1.98305045
22MP0001819_abnormal_immune_cell1.97282512
23MP0005000_abnormal_immune_tolerance1.96259149
24MP0002723_abnormal_immune_serum1.93502521
25MP0002398_abnormal_bone_marrow1.88830081
26MP0002452_abnormal_antigen_presenting1.88499643
27MP0002722_abnormal_immune_system1.71524032
28MP0008260_abnormal_autophagy1.70061735
29MP0002405_respiratory_system_inflammati1.68807303
30MP0000689_abnormal_spleen_morphology1.67056283
31MP0000716_abnormal_immune_system1.65830060
32MP0003300_gastrointestinal_ulcer1.63217488
33MP0003763_abnormal_thymus_physiology1.59704723
34MP0003656_abnormal_erythrocyte_physiolo1.50928814
35MP0005671_abnormal_response_to1.50164043
36MP0000703_abnormal_thymus_morphology1.47323045
37MP0002166_altered_tumor_susceptibility1.47027897
38MP0002429_abnormal_blood_cell1.45194347
39MP0009785_altered_susceptibility_to1.44421993
40MP0000685_abnormal_immune_system1.43887927
41MP0005670_abnormal_white_adipose1.42832800
42MP0001533_abnormal_skeleton_physiology1.40414745
43MP0004947_skin_inflammation1.39358501
44MP0003698_abnormal_male_reproductive1.37194533
45MP0006082_CNS_inflammation1.36018181
46MP0005174_abnormal_tail_pigmentation1.34007248
47MP0005387_immune_system_phenotype1.32151973
48MP0001790_abnormal_immune_system1.32151973
49MP0008057_abnormal_DNA_replication1.30039505
50MP0002132_abnormal_respiratory_system1.27924012
51MP0001853_heart_inflammation1.24469766
52MP0010155_abnormal_intestine_physiology1.24017245
53MP0003183_abnormal_peptide_metabolism1.23659987
54MP0001845_abnormal_inflammatory_respons1.20053978
55MP0002148_abnormal_hypersensitivity_rea1.19560797
56MP0005076_abnormal_cell_differentiation1.15540626
57MP0001929_abnormal_gametogenesis1.14584966
58MP0008004_abnormal_stomach_pH1.14098186
59MP0001851_eye_inflammation1.12667448
60MP0005310_abnormal_salivary_gland1.12098858
61MP0002998_abnormal_bone_remodeling1.11981108
62MP0000015_abnormal_ear_pigmentation1.11506090
63MP0001765_abnormal_ion_homeostasis1.08781232
64MP0008469_abnormal_protein_level1.07894826
65MP0005451_abnormal_body_composition1.06810946
66MP0000604_amyloidosis1.06775833
67MP0005075_abnormal_melanosome_morpholog1.06609326
68MP0004130_abnormal_muscle_cell1.04437647
69MP0010307_abnormal_tumor_latency1.01007671
70MP0009115_abnormal_fat_cell0.96216584
71MP0002933_joint_inflammation0.94566139
72MP0005377_hearing/vestibular/ear_phenot0.91920299
73MP0003878_abnormal_ear_physiology0.91920299
74MP0003866_abnormal_defecation0.91858379
75MP0005220_abnormal_exocrine_pancreas0.91369985
76MP0008961_abnormal_basal_metabolism0.85769450
77MP0000249_abnormal_blood_vessel0.82905497
78MP0009764_decreased_sensitivity_to0.79670212
79MP0002019_abnormal_tumor_incidence0.77020781
80MP0005666_abnormal_adipose_tissue0.76122096
81MP0000681_abnormal_thyroid_gland0.76035859
82MP0001986_abnormal_taste_sensitivity0.75194269
83MP0002928_abnormal_bile_duct0.74688701
84MP0004742_abnormal_vestibular_system0.72450684
85MP0003091_abnormal_cell_migration0.72429466
86MP0003329_amyloid_beta_deposits0.70778297
87MP0002006_tumorigenesis0.70354976
88MP0003252_abnormal_bile_duct0.69233721
89MP0002971_abnormal_brown_adipose0.69183801
90MP0009765_abnormal_xenobiotic_induced0.68610456
91MP0009763_increased_sensitivity_to0.67445019
92MP0005390_skeleton_phenotype0.66204013
93MP0009333_abnormal_splenocyte_physiolog0.66195255
94MP0002138_abnormal_hepatobiliary_system0.65850737
95MP0002161_abnormal_fertility/fecundity0.64992084
96MP0004484_altered_response_of0.62206542
97MP0003191_abnormal_cellular_cholesterol0.61655923
98MP0008995_early_reproductive_senescence0.61529799
99MP0005535_abnormal_body_temperature0.60910428
100MP0004381_abnormal_hair_follicle0.60210020

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)4.87833185
2Thrombocytosis (HP:0001894)4.47521527
3Acute lymphatic leukemia (HP:0006721)4.39056224
4Recurrent abscess formation (HP:0002722)4.04155335
5Panhypogammaglobulinemia (HP:0003139)3.87861027
6Elevated erythrocyte sedimentation rate (HP:0003565)3.87077902
7Epistaxis (HP:0000421)3.86921952
8Acute myeloid leukemia (HP:0004808)3.83403333
9Recurrent bacterial skin infections (HP:0005406)3.81384098
10Gingival bleeding (HP:0000225)3.63961871
11Petechiae (HP:0000967)3.58017223
12Recurrent cutaneous fungal infections (HP:0011370)3.53289358
13Chronic mucocutaneous candidiasis (HP:0002728)3.53289358
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.34897603
15Chronic obstructive pulmonary disease (HP:0006510)3.25560045
16Obstructive lung disease (HP:0006536)3.25560045
17Recurrent fungal infections (HP:0002841)3.24696162
18Granulocytopenia (HP:0001913)3.18650501
19Severe visual impairment (HP:0001141)3.16433691
20Abnormal platelet volume (HP:0011876)3.11728477
21Myositis (HP:0100614)3.06370838
22Abnormal delayed hypersensitivity skin test (HP:0002963)2.95828793
23Recurrent skin infections (HP:0001581)2.92500221
24Chest pain (HP:0100749)2.84585277
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.83963840
26Increased mean platelet volume (HP:0011877)2.81512236
27Agammaglobulinemia (HP:0004432)2.80260897
28Recurrent viral infections (HP:0004429)2.79874000
29Stomatitis (HP:0010280)2.74153280
30Increased cerebral lipofuscin (HP:0011813)2.71354137
31Colitis (HP:0002583)2.66783684
32Spondylolisthesis (HP:0003302)2.66558246
33Abnormality of B cell number (HP:0010975)2.66079445
34Inflammation of the large intestine (HP:0002037)2.65049859
35Impaired platelet aggregation (HP:0003540)2.64962183
36Abnormal platelet function (HP:0011869)2.64962183
37Hypoplasia of the thymus (HP:0000778)2.64714529
38Menorrhagia (HP:0000132)2.64485670
39Leukocytosis (HP:0001974)2.63323433
40Abnormality of the fingertips (HP:0001211)2.61291246
41Gastrointestinal inflammation (HP:0004386)2.58817414
42B lymphocytopenia (HP:0010976)2.57728923
43Aplasia/Hypoplasia of the thymus (HP:0010515)2.55205164
44Meningitis (HP:0001287)2.54695005
45Abnormality of macrophages (HP:0004311)2.53742047
46Purpura (HP:0000979)2.49000722
47Eczematoid dermatitis (HP:0000976)2.46103280
48Thoracic kyphosis (HP:0002942)2.40475407
49Gingivitis (HP:0000230)2.40008928
50Periodontitis (HP:0000704)2.39688065
51Abnormality of the prostate (HP:0008775)2.38264982
52Encephalitis (HP:0002383)2.36635763
53Gastrointestinal infarctions (HP:0005244)2.36316931
54Cellulitis (HP:0100658)2.35404123
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.34519983
56Absent/shortened dynein arms (HP:0200106)2.34519983
57Viral hepatitis (HP:0006562)2.25493447
58Hypophosphatemic rickets (HP:0004912)2.24258547
59Enlarged epiphyses (HP:0010580)2.23491649
60Nasal polyposis (HP:0100582)2.19974376
61Amyloidosis (HP:0011034)2.19861721
62Chronic otitis media (HP:0000389)2.19783052
63Spontaneous hematomas (HP:0007420)2.17640544
64Abnormality of T cell physiology (HP:0011840)2.16872353
65Slow saccadic eye movements (HP:0000514)2.15716169
66Polygenic inheritance (HP:0010982)2.14020465
67Arterial thrombosis (HP:0004420)2.13817715
68Eosinophilia (HP:0001880)2.10490883
69Asymmetric septal hypertrophy (HP:0001670)2.09250615
70Dysostosis multiplex (HP:0000943)2.03153770
71Hemoptysis (HP:0002105)2.02839039
72Hypoplastic ischia (HP:0003175)1.99232706
73Abnormality of T cells (HP:0002843)1.98095211
74Broad face (HP:0000283)1.97403917
75Truncal obesity (HP:0001956)1.94467254
76Abnormality of the thoracic spine (HP:0100711)1.93521968
77Mediastinal lymphadenopathy (HP:0100721)1.93492485
78Thin bony cortex (HP:0002753)1.92082859
79Abnormality of the nasal mucosa (HP:0000433)1.91952796
80Increased IgE level (HP:0003212)1.90137095
81Autoimmune hemolytic anemia (HP:0001890)1.89512259
82Autoimmune thrombocytopenia (HP:0001973)1.88515738
83Abnormality of the thymus (HP:0000777)1.85346598
84Progressive hearing impairment (HP:0001730)1.83615310
85Abnormality of the lumbar spine (HP:0100712)1.83428480
86Orchitis (HP:0100796)1.82280003
87Episodic fever (HP:0001954)1.81856254
88Recurrent gram-negative bacterial infections (HP:0005420)1.81679668
89Abnormality of eosinophils (HP:0001879)1.80046130
90Pulmonary fibrosis (HP:0002206)1.78113485
91Abnormality of iron homeostasis (HP:0011031)1.77606997
92Vacuolated lymphocytes (HP:0001922)1.77143266
93Vasculitis (HP:0002633)1.76313229
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76084002
95Hypertriglyceridemia (HP:0002155)1.74603176
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74251733
97Prominent nose (HP:0000448)1.72510743
98Abnormality of the peritoneum (HP:0002585)1.69859009
99Vertigo (HP:0002321)1.69239472
100Chronic hepatic failure (HP:0100626)1.68857373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.99882092
2KIT3.48546868
3MAP2K33.09878311
4MAP3K142.94397811
5FES2.82899505
6TEC2.58463641
7CDK122.42886031
8FLT32.30677295
9BLK2.12962548
10MAP3K132.07871462
11BTK2.06544417
12TAOK32.05522507
13MAP4K11.85168600
14ZAP701.78421489
15PRPF4B1.77157384
16TBK11.72505096
17SYK1.71995766
18CSF1R1.71679029
19BMPR21.63594181
20PIK3CG1.61686392
21BRD41.60185794
22ITK1.57584802
23TRIB31.51790712
24IKBKB1.50966240
25TNK21.50050799
26ERN11.49452614
27GRK61.45705602
28EEF2K1.43956182
29IKBKE1.42619940
30MARK21.32659182
31TXK1.29541988
32MAP3K71.29475519
33PDK11.23316723
34PDPK11.22795557
35PLK41.22191991
36JAK31.19991455
37CDK41.19091237
38CDK61.15462157
39LYN1.15159065
40WNK41.13695415
41TYK21.11248629
42TRPM71.06542907
43LCK1.05614253
44WNK11.04744688
45HCK1.01597347
46SIK20.95700188
47MAP2K60.93783519
48MAP3K60.92136255
49RET0.87903026
50MAPK150.87238917
51CAMK1G0.87238550
52PASK0.86564471
53MAP2K20.85380238
54JAK10.84747255
55PRKD20.81281389
56PKN20.81059238
57IRAK40.80181489
58PRKAA20.77196081
59HIPK20.76662987
60DYRK1B0.74504968
61MAPK120.74146956
62RPS6KA40.73078178
63PRKCQ0.70363053
64STK380.69914621
65MAP3K10.66984957
66MAPK70.66052735
67STK100.65869045
68JAK20.65529616
69MAPK110.65470570
70MAP2K40.62127528
71RPS6KA20.61586309
72MATK0.61436261
73RPS6KA60.61103010
74RPS6KC10.60150179
75RPS6KL10.60150179
76CAMK40.59575906
77MAP3K110.58437106
78FRK0.57595657
79CSK0.57561323
80MAP3K30.56923569
81FGR0.55684189
82PTK2B0.55474042
83MAPK30.52707271
84TTN0.52540836
85MKNK10.47664323
86NEK60.47187595
87MARK30.46713511
88TESK10.46441108
89NEK90.43891738
90CAMK10.42657116
91MTOR0.42389361
92CDK70.42178721
93CHUK0.41675787
94RPS6KA10.41531370
95MAPK10.39070781
96CAMK1D0.37151283
97MAP3K100.37080843
98ATR0.31915478
99SIK30.30536127
100ABL10.30050393

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.02471482
2Acute myeloid leukemia_Homo sapiens_hsa052212.66427940
3B cell receptor signaling pathway_Homo sapiens_hsa046622.48956986
4Leishmaniasis_Homo sapiens_hsa051402.20252040
5Platelet activation_Homo sapiens_hsa046112.07783638
6Osteoclast differentiation_Homo sapiens_hsa043802.04312037
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95571249
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.91429422
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90305982
10Dorso-ventral axis formation_Homo sapiens_hsa043201.74341109
11Hematopoietic cell lineage_Homo sapiens_hsa046401.70790069
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.60409605
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55169700
14T cell receptor signaling pathway_Homo sapiens_hsa046601.54298994
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52763854
16Influenza A_Homo sapiens_hsa051641.45727882
17Primary immunodeficiency_Homo sapiens_hsa053401.45152935
18Non-small cell lung cancer_Homo sapiens_hsa052231.41888664
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40893520
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38218291
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37416434
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34277724
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.31832772
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29674354
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27986114
26Legionellosis_Homo sapiens_hsa051341.27830282
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.27350424
28Inositol phosphate metabolism_Homo sapiens_hsa005621.26722247
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18546364
30Tuberculosis_Homo sapiens_hsa051521.17872406
31Chemokine signaling pathway_Homo sapiens_hsa040621.17564693
32Chronic myeloid leukemia_Homo sapiens_hsa052201.16630755
33Prolactin signaling pathway_Homo sapiens_hsa049171.15697869
34Measles_Homo sapiens_hsa051621.14717717
35Malaria_Homo sapiens_hsa051441.13909716
36TNF signaling pathway_Homo sapiens_hsa046681.12155989
37Staphylococcus aureus infection_Homo sapiens_hsa051501.12034840
38Toxoplasmosis_Homo sapiens_hsa051451.08170463
39Olfactory transduction_Homo sapiens_hsa047401.07664102
40Herpes simplex infection_Homo sapiens_hsa051681.06534725
41Lysine degradation_Homo sapiens_hsa003101.06268647
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.05678714
43Graft-versus-host disease_Homo sapiens_hsa053321.01618012
44Hepatitis B_Homo sapiens_hsa051611.01461790
45Antigen processing and presentation_Homo sapiens_hsa046121.01260709
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00704246
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96396037
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.96118452
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95888514
50Allograft rejection_Homo sapiens_hsa053300.91622856
51Insulin resistance_Homo sapiens_hsa049310.91622213
52Type II diabetes mellitus_Homo sapiens_hsa049300.91234017
53Viral carcinogenesis_Homo sapiens_hsa052030.90365710
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.89693540
55VEGF signaling pathway_Homo sapiens_hsa043700.89256369
56mTOR signaling pathway_Homo sapiens_hsa041500.89045110
57Fatty acid biosynthesis_Homo sapiens_hsa000610.88643010
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87895686
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86880262
60Autoimmune thyroid disease_Homo sapiens_hsa053200.85040418
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84775403
62Pancreatic cancer_Homo sapiens_hsa052120.84131401
63GnRH signaling pathway_Homo sapiens_hsa049120.81339533
64ABC transporters_Homo sapiens_hsa020100.78577083
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77946905
66Amoebiasis_Homo sapiens_hsa051460.77935993
67Lysosome_Homo sapiens_hsa041420.77612719
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.75046518
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.73232427
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.72669023
71Renin-angiotensin system_Homo sapiens_hsa046140.70420413
72Choline metabolism in cancer_Homo sapiens_hsa052310.69040532
73Pertussis_Homo sapiens_hsa051330.68549221
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68458918
75Notch signaling pathway_Homo sapiens_hsa043300.64991092
76Shigellosis_Homo sapiens_hsa051310.64578756
77Pentose phosphate pathway_Homo sapiens_hsa000300.63153581
78Type I diabetes mellitus_Homo sapiens_hsa049400.63148027
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.63073204
80Salivary secretion_Homo sapiens_hsa049700.62672058
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61930966
82MAPK signaling pathway_Homo sapiens_hsa040100.60658745
83Estrogen signaling pathway_Homo sapiens_hsa049150.60178095
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59118138
85African trypanosomiasis_Homo sapiens_hsa051430.58338245
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56729542
87Asthma_Homo sapiens_hsa053100.56375300
88Regulation of autophagy_Homo sapiens_hsa041400.53787621
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53429148
90Endocytosis_Homo sapiens_hsa041440.52562982
91Pancreatic secretion_Homo sapiens_hsa049720.51716501
92Epstein-Barr virus infection_Homo sapiens_hsa051690.50400085
93FoxO signaling pathway_Homo sapiens_hsa040680.50216659
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48710087
95Apoptosis_Homo sapiens_hsa042100.47360735
96HIF-1 signaling pathway_Homo sapiens_hsa040660.47259270
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47020578
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46907749
99Renal cell carcinoma_Homo sapiens_hsa052110.45977029
100HTLV-I infection_Homo sapiens_hsa051660.43384559

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