ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to Golgi (GO:0072600)	5.29294693
2	protein targeting to Golgi (GO:0000042)	4.88313998
3	L-fucose catabolic process (GO:0042355)	4.77714546
4	fucose catabolic process (GO:0019317)	4.77714546
5	L-fucose metabolic process (GO:0042354)	4.77714546
6	response to pheromone (GO:0019236)	4.68197856
7	sperm motility (GO:0030317)	4.58078757
8	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.54635932
9	tryptophan catabolic process (GO:0006569)	4.36360701
10	indole-containing compound catabolic process (GO:0042436)	4.36360701
11	indolalkylamine catabolic process (GO:0046218)	4.36360701
12	cilium or flagellum-dependent cell motility (GO:0001539)	4.31316221
13	protein localization to Golgi apparatus (GO:0034067)	4.20692745
14	protein polyglutamylation (GO:0018095)	4.16150479
15	indolalkylamine metabolic process (GO:0006586)	4.12289098
16	multicellular organism reproduction (GO:0032504)	4.06271865
17	cellular ketone body metabolic process (GO:0046950)	4.04861306
18	tryptophan metabolic process (GO:0006568)	4.03745432
19	acrosome reaction (GO:0007340)	3.97633145
20	behavioral response to nicotine (GO:0035095)	3.97207438
21	detection of light stimulus involved in sensory perception (GO:0050962)	3.94214425
22	detection of light stimulus involved in visual perception (GO:0050908)	3.94214425
23	protein K11-linked deubiquitination (GO:0035871)	3.91738243
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.71691848
25	piRNA metabolic process (GO:0034587)	3.68817419
26	ketone body metabolic process (GO:1902224)	3.55794355
27	epithelial cilium movement (GO:0003351)	3.34474881
28	neural tube formation (GO:0001841)	3.26265586
29	axoneme assembly (GO:0035082)	3.21834498
30	DNA methylation involved in gamete generation (GO:0043046)	3.18622605
31	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.17443957
32	kynurenine metabolic process (GO:0070189)	3.14053631
33	RNA destabilization (GO:0050779)	3.10324342
34	cAMP catabolic process (GO:0006198)	3.08845765
35	DNA deamination (GO:0045006)	3.08645221
36	neuronal action potential (GO:0019228)	3.03709932
37	nephron epithelium morphogenesis (GO:0072088)	3.02034208
38	nephron tubule morphogenesis (GO:0072078)	3.02034208
39	activated T cell proliferation (GO:0050798)	2.96247071
40	indole-containing compound metabolic process (GO:0042430)	2.93403365
41	sulfation (GO:0051923)	2.92983946
42	NAD biosynthetic process (GO:0009435)	2.88454545
43	spermatid development (GO:0007286)	2.86946266
44	cilium movement (GO:0003341)	2.85593171
45	regulation of action potential (GO:0098900)	2.82934630
46	cellular biogenic amine catabolic process (GO:0042402)	2.82292159
47	amine catabolic process (GO:0009310)	2.82292159
48	centriole replication (GO:0007099)	2.80740958
49	fusion of sperm to egg plasma membrane (GO:0007342)	2.80665614
50	negative regulation of telomere maintenance (GO:0032205)	2.80278422
51	retinal cone cell development (GO:0046549)	2.78294588
52	organic cation transport (GO:0015695)	2.76358963
53	DNA double-strand break processing (GO:0000729)	2.76334438
54	reproduction (GO:0000003)	2.75542824
55	seminiferous tubule development (GO:0072520)	2.74508436
56	cyclic nucleotide catabolic process (GO:0009214)	2.74262719
57	protein K63-linked deubiquitination (GO:0070536)	2.73201201
58	negative regulation of mast cell activation (GO:0033004)	2.69640983
59	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.68523636
60	adenosine metabolic process (GO:0046085)	2.67846384
61	regulation of cilium movement (GO:0003352)	2.67777165
62	cellular response to ATP (GO:0071318)	2.67532832
63	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.66726252
64	membrane depolarization during action potential (GO:0086010)	2.66702396
65	preassembly of GPI anchor in ER membrane (GO:0016254)	2.65875960
66	cell wall macromolecule catabolic process (GO:0016998)	2.63946034
67	cellular response to exogenous dsRNA (GO:0071360)	2.62791263
68	photoreceptor cell maintenance (GO:0045494)	2.62436279
69	calcium ion-dependent exocytosis (GO:0017156)	2.61325806
70	ubiquinone biosynthetic process (GO:0006744)	2.56426712
71	regulation of sarcomere organization (GO:0060297)	2.56385122
72	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.55526467
73	renal tubule morphogenesis (GO:0061333)	2.55337282
74	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.54343604
75	rRNA catabolic process (GO:0016075)	2.54160798
76	protein localization to cilium (GO:0061512)	2.53488018
77	cilium organization (GO:0044782)	2.53452312
78	positive regulation of defense response to virus by host (GO:0002230)	2.52938779
79	reflex (GO:0060004)	2.52296701
80	protein import into peroxisome matrix (GO:0016558)	2.49802242
81	sperm-egg recognition (GO:0035036)	2.49623784
82	phosphatidylethanolamine metabolic process (GO:0046337)	2.49292672
83	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.47676639
84	meiotic chromosome segregation (GO:0045132)	2.47463965
85	fucosylation (GO:0036065)	2.46662987
86	positive regulation of granulocyte differentiation (GO:0030854)	2.45239679
87	cilium assembly (GO:0042384)	2.44765179
88	mast cell degranulation (GO:0043303)	2.43605859
89	mast cell activation involved in immune response (GO:0002279)	2.43605859
90	protein prenylation (GO:0018342)	2.41995698
91	prenylation (GO:0097354)	2.41995698
92	reciprocal DNA recombination (GO:0035825)	2.41740171
93	reciprocal meiotic recombination (GO:0007131)	2.41740171
94	regulation of hexokinase activity (GO:1903299)	2.41511868
95	regulation of glucokinase activity (GO:0033131)	2.41511868
96	regulation of telomere maintenance (GO:0032204)	2.40445684
97	protein complex biogenesis (GO:0070271)	2.39569689
98	alanine transport (GO:0032328)	2.38709960
99	rhodopsin mediated signaling pathway (GO:0016056)	2.38412201
100	positive regulation of fatty acid transport (GO:2000193)	2.38226116

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.59400725
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.22278573
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.85971091
4	VDR_22108803_ChIP-Seq_LS180_Human	2.68066886
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58642442
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.47283395
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41229669
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20288823
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.19967063
10	ER_23166858_ChIP-Seq_MCF-7_Human	2.18702305
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.01445858
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00792381
13	TAF15_26573619_Chip-Seq_HEK293_Human	1.97893601
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.95223524
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94711664
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93830224
17	FUS_26573619_Chip-Seq_HEK293_Human	1.87364240
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.82846135
19	P300_19829295_ChIP-Seq_ESCs_Human	1.74785381
20	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.74039347
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.74039347
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.69088318
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67249377
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63356768
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62912154
26	EWS_26573619_Chip-Seq_HEK293_Human	1.59954198
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57615288
28	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.55031412
29	AR_25329375_ChIP-Seq_VCAP_Human	1.52044085
30	STAT3_23295773_ChIP-Seq_U87_Human	1.51839797
31	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.51562367
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.50314159
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.48391837
34	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48378806
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.48378806
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44298346
37	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.43699743
38	TCF4_23295773_ChIP-Seq_U87_Human	1.43372257
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43219727
40	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.40336999
41	DROSHA_22980978_ChIP-Seq_HELA_Human	1.39551005
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.36429682
43	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.33972865
44	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29263361
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28765979
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28213709
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28213709
48	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27512874
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27227499
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25451594
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24362064
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22965588
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22950007
54	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.21219485
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21040113
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21040113
57	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.20602211
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20493289
59	NCOR_22424771_ChIP-Seq_293T_Human	1.20192694
60	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19373440
61	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19039422
62	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.18244466
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18114005
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.17573772
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16325108
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16028401
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15946894
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15461786
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14894714
70	ERA_21632823_ChIP-Seq_H3396_Human	1.14769110
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13040993
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12433855
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11913249
74	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11655612
75	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11071615
76	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10514239
77	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09933905
78	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.08958136
79	MYC_19829295_ChIP-Seq_ESCs_Human	1.08862679
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.08795820
81	GATA3_26560356_Chip-Seq_TH2_Human	1.08778053
82	CDX2_22108803_ChIP-Seq_LS180_Human	1.08721016
83	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.08543691
84	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07536847
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06497667
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06287878
87	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05954001
88	SMRT_27268052_Chip-Seq_Bcells_Human	1.04713831
89	AR_20517297_ChIP-Seq_VCAP_Human	1.04063197
90	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.03179576
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00919123
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00553263
93	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00438679
94	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00258357
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99480708
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98901687
97	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.98117160
98	RUNX_20019798_ChIP-Seq_JUKART_Human	0.97808302
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97605203
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96517611

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.28490489
2	MP0003195_calcinosis	3.15370103
3	MP0008877_abnormal_DNA_methylation	2.94030172
4	MP0005551_abnormal_eye_electrophysiolog	2.52756494
5	MP0001986_abnormal_taste_sensitivity	2.36129130
6	MP0003646_muscle_fatigue	2.29518513
7	MP0002138_abnormal_hepatobiliary_system	2.26815071
8	MP0000569_abnormal_digit_pigmentation	2.23518477
9	MP0004043_abnormal_pH_regulation	2.11285971
10	MP0001968_abnormal_touch/_nociception	2.09401988
11	MP0008875_abnormal_xenobiotic_pharmacok	2.05176188
12	MP0001485_abnormal_pinna_reflex	1.92308727
13	MP0002102_abnormal_ear_morphology	1.92205519
14	MP0002876_abnormal_thyroid_physiology	1.90904816
15	MP0009046_muscle_twitch	1.80461751
16	MP0008872_abnormal_physiological_respon	1.76781273
17	MP0003787_abnormal_imprinting	1.73520949
18	MP0000427_abnormal_hair_cycle	1.68651635
19	MP0001835_abnormal_antigen_presentation	1.67673152
20	MP0001501_abnormal_sleep_pattern	1.64766959
21	MP0002160_abnormal_reproductive_system	1.62835726
22	MP0003698_abnormal_male_reproductive	1.62402462
23	MP0005645_abnormal_hypothalamus_physiol	1.61048701
24	MP0005253_abnormal_eye_physiology	1.59703432
25	MP0009745_abnormal_behavioral_response	1.55334675
26	MP0006072_abnormal_retinal_apoptosis	1.55312354
27	MP0003878_abnormal_ear_physiology	1.53600217
28	MP0005377_hearing/vestibular/ear_phenot	1.53600217
29	MP0004142_abnormal_muscle_tone	1.49669566
30	MP0005389_reproductive_system_phenotype	1.49604734
31	MP0005167_abnormal_blood-brain_barrier	1.45825219
32	MP0001929_abnormal_gametogenesis	1.44823399
33	MP0002837_dystrophic_cardiac_calcinosis	1.44734882
34	MP0001486_abnormal_startle_reflex	1.43970251
35	MP0005646_abnormal_pituitary_gland	1.41849082
36	MP0002735_abnormal_chemical_nociception	1.41223289
37	MP0002928_abnormal_bile_duct	1.41038482
38	MP0005084_abnormal_gallbladder_morpholo	1.39300323
39	MP0002733_abnormal_thermal_nociception	1.37558423
40	MP0004147_increased_porphyrin_level	1.34082151
41	MP0000230_abnormal_systemic_arterial	1.32762475
42	MP0003011_delayed_dark_adaptation	1.28724664
43	MP0005379_endocrine/exocrine_gland_phen	1.28654868
44	MP0006276_abnormal_autonomic_nervous	1.25588071
45	MP0000631_abnormal_neuroendocrine_gland	1.24796106
46	MP0004742_abnormal_vestibular_system	1.24231225
47	MP0001970_abnormal_pain_threshold	1.21411179
48	MP0002272_abnormal_nervous_system	1.17211442
49	MP0001765_abnormal_ion_homeostasis	1.14042447
50	MP0005310_abnormal_salivary_gland	1.13722041
51	MP0001919_abnormal_reproductive_system	1.10341401
52	MP0003252_abnormal_bile_duct	1.10226451
53	MP0002229_neurodegeneration	1.09695374
54	MP0001873_stomach_inflammation	1.08620853
55	MP0000372_irregular_coat_pigmentation	1.08481774
56	MP0002693_abnormal_pancreas_physiology	1.08206327
57	MP0005671_abnormal_response_to	1.06431123
58	MP0002064_seizures	1.06026169
59	MP0010386_abnormal_urinary_bladder	1.05152509
60	MP0003283_abnormal_digestive_organ	1.04981550
61	MP0008995_early_reproductive_senescence	1.04030391
62	MP0004885_abnormal_endolymph	1.03910852
63	MP0005174_abnormal_tail_pigmentation	1.03582874
64	MP0001800_abnormal_humoral_immune	1.03175449
65	MP0004924_abnormal_behavior	1.02135530
66	MP0005386_behavior/neurological_phenoty	1.02135530
67	MP0002572_abnormal_emotion/affect_behav	1.02084455
68	MP0001905_abnormal_dopamine_level	0.97550130
69	MP0004130_abnormal_muscle_cell	0.97148841
70	MP0003183_abnormal_peptide_metabolism	0.95693296
71	MP0004133_heterotaxia	0.92585983
72	MP0004484_altered_response_of	0.92505512
73	MP0005220_abnormal_exocrine_pancreas	0.92481038
74	MP0002736_abnormal_nociception_after	0.91836417
75	MP0002638_abnormal_pupillary_reflex	0.91301097
76	MP0009764_decreased_sensitivity_to	0.90311443
77	MP0002210_abnormal_sex_determination	0.88831805
78	MP0002067_abnormal_sensory_capabilities	0.86237422
79	MP0004145_abnormal_muscle_electrophysio	0.83977964
80	MP0001963_abnormal_hearing_physiology	0.83568923
81	MP0005448_abnormal_energy_balance	0.81895739
82	MP0000470_abnormal_stomach_morphology	0.81552358
83	MP0000015_abnormal_ear_pigmentation	0.80808505
84	MP0000653_abnormal_sex_gland	0.80437473
85	MP0000383_abnormal_hair_follicle	0.80254299
86	MP0002557_abnormal_social/conspecific_i	0.80176926
87	MP0003724_increased_susceptibility_to	0.79406589
88	MP0010329_abnormal_lipoprotein_level	0.77174224
89	MP0001145_abnormal_male_reproductive	0.76337805
90	MP0000685_abnormal_immune_system	0.75782430
91	MP0005075_abnormal_melanosome_morpholog	0.75295171
92	MP0003718_maternal_effect	0.74713499
93	MP0002723_abnormal_immune_serum	0.73359241
94	MP0006292_abnormal_olfactory_placode	0.72875822
95	MP0005332_abnormal_amino_acid	0.72855895
96	MP0002163_abnormal_gland_morphology	0.72786707
97	MP0003172_abnormal_lysosome_physiology	0.71065942
98	MP0005195_abnormal_posterior_eye	0.70392341
99	MP0004085_abnormal_heartbeat	0.70268582
100	MP0002063_abnormal_learning/memory/cond	0.68876635

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.44993132
2	Congenital stationary night blindness (HP:0007642)	4.35776542
3	Attenuation of retinal blood vessels (HP:0007843)	3.98932557
4	Pancreatic fibrosis (HP:0100732)	3.96095736
5	Nephronophthisis (HP:0000090)	3.92699525
6	Molar tooth sign on MRI (HP:0002419)	3.91978648
7	Abnormality of midbrain morphology (HP:0002418)	3.91978648
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.79531077
9	True hermaphroditism (HP:0010459)	3.74540429
10	Abnormality of the renal medulla (HP:0100957)	3.49860794
11	Abnormality of the renal cortex (HP:0011035)	3.39484968
12	Type II lissencephaly (HP:0007260)	3.25914421
13	Polydipsia (HP:0001959)	3.17925182
14	Abnormal drinking behavior (HP:0030082)	3.17925182
15	Chronic hepatic failure (HP:0100626)	3.16979210
16	Cystic liver disease (HP:0006706)	3.08435124
17	Absent/shortened dynein arms (HP:0200106)	3.03167966
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.03167966
19	Large for gestational age (HP:0001520)	2.88106456
20	Abolished electroretinogram (ERG) (HP:0000550)	2.84229121
21	Bony spicule pigmentary retinopathy (HP:0007737)	2.76095117
22	Tubular atrophy (HP:0000092)	2.75426195
23	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.71063974
24	Decreased central vision (HP:0007663)	2.63506064
25	Progressive cerebellar ataxia (HP:0002073)	2.63080823
26	Severe visual impairment (HP:0001141)	2.62552523
27	Decreased circulating renin level (HP:0003351)	2.58845870
28	Abnormality of macular pigmentation (HP:0008002)	2.57094950
29	Hyperventilation (HP:0002883)	2.54336147
30	Progressive inability to walk (HP:0002505)	2.49980485
31	Polyuria (HP:0000103)	2.47181089
32	Stomatitis (HP:0010280)	2.45112630
33	Increased corneal curvature (HP:0100692)	2.42248914
34	Keratoconus (HP:0000563)	2.42248914
35	Genetic anticipation (HP:0003743)	2.41255695
36	Inability to walk (HP:0002540)	2.38738067
37	Gaze-evoked nystagmus (HP:0000640)	2.37179660
38	Stomach cancer (HP:0012126)	2.33286546
39	Congenital sensorineural hearing impairment (HP:0008527)	2.32590732
40	Renal cortical cysts (HP:0000803)	2.27563420
41	Abnormality of alanine metabolism (HP:0010916)	2.26680473
42	Hyperalaninemia (HP:0003348)	2.26680473
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.26680473
44	Congenital, generalized hypertrichosis (HP:0004540)	2.25974736
45	Cerebellar dysplasia (HP:0007033)	2.25370286
46	Congenital hepatic fibrosis (HP:0002612)	2.25300885
47	Bile duct proliferation (HP:0001408)	2.24787292
48	Abnormal biliary tract physiology (HP:0012439)	2.24787292
49	Medial flaring of the eyebrow (HP:0010747)	2.24611166
50	Widely spaced teeth (HP:0000687)	2.20411040
51	Hypothermia (HP:0002045)	2.19895356
52	Clumsiness (HP:0002312)	2.14742466
53	Abnormal ciliary motility (HP:0012262)	2.14440162
54	Pendular nystagmus (HP:0012043)	2.13780095
55	Abnormal urine output (HP:0012590)	2.08833093
56	Sclerocornea (HP:0000647)	2.08155767
57	Furrowed tongue (HP:0000221)	2.05777719
58	Abnormal respiratory epithelium morphology (HP:0012253)	2.03016137
59	Abnormal respiratory motile cilium morphology (HP:0005938)	2.03016137
60	Lissencephaly (HP:0001339)	2.00600807
61	Febrile seizures (HP:0002373)	1.95515831
62	Neoplasm of the adrenal cortex (HP:0100641)	1.94583431
63	Male pseudohermaphroditism (HP:0000037)	1.94512690
64	Tubulointerstitial nephritis (HP:0001970)	1.94404414
65	Anencephaly (HP:0002323)	1.92922108
66	Thyroiditis (HP:0100646)	1.90167428
67	Bulbous nose (HP:0000414)	1.88059721
68	Hypoplastic ischia (HP:0003175)	1.87929235
69	Panhypogammaglobulinemia (HP:0003139)	1.87467111
70	Elevated erythrocyte sedimentation rate (HP:0003565)	1.87407804
71	Protruding tongue (HP:0010808)	1.87141141
72	Abnormality of renal excretion (HP:0011036)	1.85886271
73	Macular degeneration (HP:0000608)	1.85878309
74	Fair hair (HP:0002286)	1.84198769
75	Mesangial abnormality (HP:0001966)	1.83978550
76	Hyperkalemia (HP:0002153)	1.83854356
77	Enlarged epiphyses (HP:0010580)	1.82620337
78	3-Methylglutaconic aciduria (HP:0003535)	1.82367619
79	Abnormality of the renal collecting system (HP:0004742)	1.80282276
80	Ketosis (HP:0001946)	1.78847454
81	Duplicated collecting system (HP:0000081)	1.76603138
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74291928
83	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.73389248
84	Constricted visual fields (HP:0001133)	1.73099844
85	Facial shape deformation (HP:0011334)	1.73069069
86	Potter facies (HP:0002009)	1.73069069
87	Amelogenesis imperfecta (HP:0000705)	1.72865309
88	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.72387209
89	Severe muscular hypotonia (HP:0006829)	1.71895100
90	Tubulointerstitial abnormality (HP:0001969)	1.70878445
91	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.69924898
92	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.69353837
93	Hypoplasia of the fovea (HP:0007750)	1.69353837
94	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.68385476
95	Abnormal respiratory motile cilium physiology (HP:0012261)	1.67609230
96	Abnormality of T cell physiology (HP:0011840)	1.64271759
97	Stage 5 chronic kidney disease (HP:0003774)	1.63388210
98	Clubbing of toes (HP:0100760)	1.62924998
99	Abnormality of B cell number (HP:0010975)	1.61013469
100	Gait imbalance (HP:0002141)	1.60715210

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.82720810
2	BMPR1B	3.28227378
3	ADRBK2	2.83439319
4	WNK4	2.80633048
5	TAOK3	2.77349087
6	ZAK	2.76316780
7	GRK1	2.70060348
8	PINK1	2.56167138
9	INSRR	2.46894458
10	MAP4K2	2.26872700
11	AKT3	2.08892524
12	PLK4	2.00970387
13	WNK3	1.95985045
14	KIT	1.93209629
15	NUAK1	1.81859982
16	ACVR1B	1.80794569
17	TLK1	1.75733547
18	MAPK13	1.52153996
19	FLT3	1.40883612
20	TXK	1.40369351
21	OXSR1	1.34159276
22	PNCK	1.33913969
23	TEC	1.31078884
24	MAP3K4	1.30937048
25	STK39	1.27277118
26	PIK3CG	1.26494809
27	MAPKAPK3	1.19929562
28	DAPK2	1.17299895
29	TNIK	1.16432781
30	WNK1	1.13002316
31	PLK2	1.09973036
32	TRPM7	1.09756371
33	SYK	1.08433785
34	IKBKB	1.00782765
35	ITK	0.99701471
36	PTK2B	0.99453434
37	CSF1R	0.98443740
38	CAMK1G	0.97655835
39	TGFBR1	0.97346728
40	MAPK15	0.90553146
41	ADRBK1	0.90201515
42	BLK	0.89671713
43	STK38L	0.87480357
44	CAMK1D	0.87326471
45	MAP2K7	0.83276445
46	CAMKK2	0.82972407
47	MAP4K1	0.81949452
48	MUSK	0.80176242
49	BTK	0.78525867
50	PAK3	0.78167584
51	MKNK2	0.73331624
52	TNK2	0.70509836
53	PRKAA2	0.67676275
54	VRK1	0.67393706
55	PRKCQ	0.67371788
56	SIK2	0.66092499
57	PRKCE	0.65396493
58	NTRK3	0.64712021
59	MAPKAPK5	0.63885481
60	SGK2	0.62712025
61	IRAK1	0.61138662
62	MAP2K6	0.60091428
63	OBSCN	0.58856470
64	NME1	0.58001601
65	CAMK1	0.57387188
66	LYN	0.55308394
67	IKBKE	0.55059284
68	BCKDK	0.54068288
69	CHUK	0.53340115
70	RPS6KA5	0.50954779
71	PRKCG	0.49608743
72	MAP3K7	0.49214002
73	GRK6	0.48897861
74	NLK	0.48404341
75	PRKCH	0.47875804
76	CSNK1G3	0.46695189
77	CSNK1G2	0.46024655
78	RPS6KA6	0.45947770
79	PDK1	0.44509741
80	PRKAA1	0.44222432
81	STK11	0.44212355
82	LCK	0.42143281
83	PRKG1	0.41924471
84	FES	0.41811505
85	SGK494	0.41149256
86	SGK223	0.41149256
87	PIK3CA	0.40669119
88	FGFR2	0.40326172
89	CSNK1A1L	0.40166207
90	GRK7	0.39846711
91	PHKG1	0.39433648
92	PHKG2	0.39433648
93	PRKACA	0.36220302
94	CAMK4	0.36218795
95	CSNK1G1	0.36218466
96	STK3	0.35314755
97	CDK3	0.35227972
98	CDK9	0.34997690
99	BRD4	0.34205900
100	DYRK2	0.32622605

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	2.64063403
2	Phototransduction_Homo sapiens_hsa04744	2.55816695
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.53958604
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.53776486
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.44893352
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25005336
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.21880569
8	Butanoate metabolism_Homo sapiens_hsa00650	2.21007293
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.14163972
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.12813269
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.06469689
12	Asthma_Homo sapiens_hsa05310	1.98905569
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.88582057
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.87420797
15	Olfactory transduction_Homo sapiens_hsa04740	1.82458749
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80322823
17	Caffeine metabolism_Homo sapiens_hsa00232	1.71650395
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.68120340
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.65820031
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.61563553
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.57685993
22	Morphine addiction_Homo sapiens_hsa05032	1.56513682
23	Allograft rejection_Homo sapiens_hsa05330	1.53400519
24	ABC transporters_Homo sapiens_hsa02010	1.49449188
25	Nicotine addiction_Homo sapiens_hsa05033	1.47592828
26	Taste transduction_Homo sapiens_hsa04742	1.46539843
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.42558218
28	Graft-versus-host disease_Homo sapiens_hsa05332	1.38875786
29	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.34802183
30	Salivary secretion_Homo sapiens_hsa04970	1.32605949
31	Circadian entrainment_Homo sapiens_hsa04713	1.28500850
32	Serotonergic synapse_Homo sapiens_hsa04726	1.26866556
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24736869
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23533026
35	Insulin secretion_Homo sapiens_hsa04911	1.20177644
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.16610112
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.14831064
38	Homologous recombination_Homo sapiens_hsa03440	1.08261458
39	GABAergic synapse_Homo sapiens_hsa04727	1.08070795
40	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.04279861
41	Regulation of autophagy_Homo sapiens_hsa04140	1.02125063
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01952109
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.01460805
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.00753924
45	Calcium signaling pathway_Homo sapiens_hsa04020	1.00040621
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97712007
47	Propanoate metabolism_Homo sapiens_hsa00640	0.97605167
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95731368
49	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.95236944
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.93736114
51	Basal transcription factors_Homo sapiens_hsa03022	0.93320218
52	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.89161212
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.85751663
54	Peroxisome_Homo sapiens_hsa04146	0.84619753
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82457924
56	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.80009360
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79212568
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78081224
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76508973
60	Retinol metabolism_Homo sapiens_hsa00830	0.76185771
61	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.73334298
62	Renin secretion_Homo sapiens_hsa04924	0.71575737
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.70751221
64	Cholinergic synapse_Homo sapiens_hsa04725	0.70127642
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.70017983
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.69472865
67	Oxidative phosphorylation_Homo sapiens_hsa00190	0.69135263
68	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.68459658
69	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.65005461
70	Lysine degradation_Homo sapiens_hsa00310	0.64704063
71	Type II diabetes mellitus_Homo sapiens_hsa04930	0.63482043
72	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.63134258
73	Long-term depression_Homo sapiens_hsa04730	0.62449768
74	Pancreatic secretion_Homo sapiens_hsa04972	0.62011635
75	RNA degradation_Homo sapiens_hsa03018	0.61945749
76	RNA polymerase_Homo sapiens_hsa03020	0.61739856
77	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61315060
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.56035964
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.54939553
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.54655906
81	Platelet activation_Homo sapiens_hsa04611	0.52721798
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.49965215
83	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49619109
84	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.49363462
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49229759
86	Purine metabolism_Homo sapiens_hsa00230	0.48787161
87	Gastric acid secretion_Homo sapiens_hsa04971	0.47678297
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46072524
89	Fatty acid degradation_Homo sapiens_hsa00071	0.45502353
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44724963
91	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.43407099
92	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.43136448
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.42602148
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42046946
95	Histidine metabolism_Homo sapiens_hsa00340	0.41641333
96	One carbon pool by folate_Homo sapiens_hsa00670	0.41609733
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41240462
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.41121793
99	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.40375972
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39907906

GOLGA8R

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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