GOLGA8S

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of antigen processing and presentation of peptide antigen (GO:0002583)9.40655418
2antigen processing and presentation via MHC class Ib (GO:0002475)9.14695650
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)8.27900307
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.70949864
5antigen processing and presentation of endogenous antigen (GO:0019883)7.35859893
6DNA strand renaturation (GO:0000733)6.59584526
7positive regulation of antigen processing and presentation (GO:0002579)6.49920927
8negative regulation of granulocyte differentiation (GO:0030853)5.80996958
9positive regulation of B cell differentiation (GO:0045579)5.78271238
10negative regulation of bone resorption (GO:0045779)5.27592338
11T cell migration (GO:0072678)4.94981352
12immunoglobulin mediated immune response (GO:0016064)4.77937178
13regulation of antigen processing and presentation (GO:0002577)4.77163756
14cellular response to exogenous dsRNA (GO:0071360)4.49848791
15neutrophil activation involved in immune response (GO:0002283)4.34521375
16negative regulation of bone remodeling (GO:0046851)4.04910256
17regulation of B cell differentiation (GO:0045577)3.93458328
18regulation of interferon-beta biosynthetic process (GO:0045357)3.87092167
19cell wall macromolecule catabolic process (GO:0016998)3.80864731
20B cell mediated immunity (GO:0019724)3.71383431
21peptidyl-lysine dimethylation (GO:0018027)3.67946854
22regulation of granulocyte differentiation (GO:0030852)3.67201791
23cell wall macromolecule metabolic process (GO:0044036)3.64131623
24rRNA methylation (GO:0031167)3.60227754
25positive regulation of chemokine biosynthetic process (GO:0045080)3.54832815
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.49622351
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.49622351
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.49622351
29modulation by symbiont of host immune response (GO:0052553)3.49622351
30positive regulation by symbiont of host defense response (GO:0052509)3.49622351
31modulation by symbiont of host defense response (GO:0052031)3.49622351
32multicellular organism reproduction (GO:0032504)3.46985740
33regulation of chemokine biosynthetic process (GO:0045073)3.43785147
34positive regulation of gamma-delta T cell activation (GO:0046645)3.43772792
35negative regulation of tissue remodeling (GO:0034104)3.40326778
36macrophage activation involved in immune response (GO:0002281)3.34130565
37microglial cell activation (GO:0001774)3.32935996
38cellular response to interferon-beta (GO:0035458)3.31450940
39regulation of monocyte differentiation (GO:0045655)3.27702342
40mast cell activation (GO:0045576)3.27457755
41adaptation of signaling pathway (GO:0023058)3.20447068
42regulation of activation of Janus kinase activity (GO:0010533)3.18384239
43positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.15409769
44rRNA modification (GO:0000154)3.14772592
45mitotic nuclear envelope reassembly (GO:0007084)3.11180697
46nuclear envelope reassembly (GO:0031468)3.11180697
47neutrophil mediated immunity (GO:0002446)3.06899173
48sperm motility (GO:0030317)3.06875103
49cellular extravasation (GO:0045123)3.06640184
50negative regulation of B cell proliferation (GO:0030889)3.05827351
51response to peptidoglycan (GO:0032494)3.05206282
52sperm capacitation (GO:0048240)3.05110202
53negative regulation of catenin import into nucleus (GO:0035414)2.99847797
54regulation of interleukin-6 biosynthetic process (GO:0045408)2.96703108
55thrombin receptor signaling pathway (GO:0070493)2.95060795
56negative regulation of interleukin-6 production (GO:0032715)2.94142359
57piRNA metabolic process (GO:0034587)2.93720258
58response to interferon-beta (GO:0035456)2.92209055
59response to host (GO:0075136)2.90330898
60response to host defenses (GO:0052200)2.90330898
61response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90330898
62regulation of hypersensitivity (GO:0002883)2.89212187
63myeloid cell activation involved in immune response (GO:0002275)2.87841273
64leukocyte tethering or rolling (GO:0050901)2.85372532
65positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.81684486
66regulation of gamma-delta T cell differentiation (GO:0045586)2.79664315
67B cell receptor signaling pathway (GO:0050853)2.78911532
68regulation of gamma-delta T cell activation (GO:0046643)2.74892366
69Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74716309
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.74323929
71response to host immune response (GO:0052572)2.74323929
72neutrophil activation (GO:0042119)2.71726893
73regulation of synapse maturation (GO:0090128)2.67573941
74lymphocyte migration (GO:0072676)2.66006469
75negative thymic T cell selection (GO:0045060)2.65773477
76autophagic vacuole fusion (GO:0000046)2.62536808
77I-kappaB phosphorylation (GO:0007252)2.60771423
78histone H3-K36 demethylation (GO:0070544)2.59861130
79platelet dense granule organization (GO:0060155)2.57872315
80response to muramyl dipeptide (GO:0032495)2.53221528
81B cell homeostasis (GO:0001782)2.52781740
82negative T cell selection (GO:0043383)2.50121774
83determination of adult lifespan (GO:0008340)2.50094302
84negative regulation of osteoclast differentiation (GO:0045671)2.48940707
85positive regulation of interleukin-17 production (GO:0032740)2.48454202
86myeloid leukocyte mediated immunity (GO:0002444)2.47362937
87regulation of defense response to virus by host (GO:0050691)2.46809324
88DNA methylation involved in gamete generation (GO:0043046)2.45388350
89positive regulation of defense response to virus by host (GO:0002230)2.44577989
90granulocyte activation (GO:0036230)2.44515464
91positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.42667859
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42578393
93membrane protein intracellular domain proteolysis (GO:0031293)2.42093301
94reproduction (GO:0000003)2.41963810
95peptidyl-lysine methylation (GO:0018022)2.40972504
96actin nucleation (GO:0045010)2.39181802
97negative regulation of interleukin-8 production (GO:0032717)2.38595070
98negative regulation of T cell mediated immunity (GO:0002710)2.35343533
99positive regulation of interferon-alpha production (GO:0032727)2.34346190
100gonadal mesoderm development (GO:0007506)18.1296960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.13759286
2E2F7_22180533_ChIP-Seq_HELA_Human4.47275027
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.31982915
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.86158138
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.33784966
6RUNX_20019798_ChIP-Seq_JUKART_Human2.73496804
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69100224
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56661380
9MYB_26560356_Chip-Seq_TH2_Human2.50922828
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42526982
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.35690821
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33139647
13VDR_21846776_ChIP-Seq_THP-1_Human2.23082405
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07376705
15SCL_19346495_ChIP-Seq_HPC-7_Human2.03619613
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02764685
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02713170
18CIITA_25753668_ChIP-Seq_RAJI_Human1.98153456
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96374743
20MYB_26560356_Chip-Seq_TH1_Human1.92909287
21VDR_24763502_ChIP-Seq_THP-1_Human1.88707744
22SPI1_23547873_ChIP-Seq_NB4_Human1.85355249
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83466827
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82781996
25GATA3_26560356_Chip-Seq_TH2_Human1.69166205
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65387944
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.58166472
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57559063
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54608447
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54496629
31MAF_26560356_Chip-Seq_TH1_Human1.50343420
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.46660629
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44999698
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44843695
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44366456
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.43770494
37ZNF274_21170338_ChIP-Seq_K562_Hela1.41204358
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39925492
39UTX_26944678_Chip-Seq_JUKART_Human1.38559959
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37857865
41VDR_23849224_ChIP-Seq_CD4+_Human1.34671325
42BCL6_27268052_Chip-Seq_Bcells_Human1.29963708
43MYC_22102868_ChIP-Seq_BL_Human1.29069514
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27974343
45MAF_26560356_Chip-Seq_TH2_Human1.26411668
46GATA3_27048872_Chip-Seq_THYMUS_Human1.24741741
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22594765
48P300_27268052_Chip-Seq_Bcells_Human1.19131010
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18603627
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15631273
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15046026
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.13903461
53TAF2_19829295_ChIP-Seq_ESCs_Human1.13358809
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12359400
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10403880
56FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10091285
57FOXP3_21729870_ChIP-Seq_TREG_Human1.10086998
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.07883171
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07255740
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06598914
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.06053035
62AR_20517297_ChIP-Seq_VCAP_Human1.05050034
63TP53_22573176_ChIP-Seq_HFKS_Human1.03811240
64RAC3_21632823_ChIP-Seq_H3396_Human1.03548291
65OCT4_20526341_ChIP-Seq_ESCs_Human0.99303324
66NOTCH1_21737748_ChIP-Seq_TLL_Human0.99000416
67NANOG_20526341_ChIP-Seq_ESCs_Human0.98768059
68GATA1_22025678_ChIP-Seq_K562_Human0.98421461
69VDR_24787735_ChIP-Seq_THP-1_Human0.98162620
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97451336
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97345741
72GATA3_21878914_ChIP-Seq_MCF-7_Human0.96865619
73NCOR_22424771_ChIP-Seq_293T_Human0.96607885
74BCOR_27268052_Chip-Seq_Bcells_Human0.96442923
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96392336
76TFEB_21752829_ChIP-Seq_HELA_Human0.96218911
77ERA_21632823_ChIP-Seq_H3396_Human0.94228357
78ETS1_20019798_ChIP-Seq_JURKAT_Human0.94028418
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93960665
80GATA3_26560356_Chip-Seq_TH1_Human0.93956524
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92696841
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92531205
83SPI1_20517297_ChIP-Seq_HL60_Human0.90796337
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.90649921
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90505325
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86428510
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86285238
88BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86024330
89YY1_21170310_ChIP-Seq_MESCs_Mouse0.85275696
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84371226
91IGF1R_20145208_ChIP-Seq_DFB_Human0.83513952
92E2F1_20622854_ChIP-Seq_HELA_Human0.83491771
93DROSHA_22980978_ChIP-Seq_HELA_Human0.83294329
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83156366
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83090838
96SMRT_27268052_Chip-Seq_Bcells_Human0.82867267
97MYC_19829295_ChIP-Seq_ESCs_Human0.82248706
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81882633
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81580279
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.81553963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.59965864
2MP0000685_abnormal_immune_system3.62850905
3MP0005671_abnormal_response_to3.57972735
4MP0002102_abnormal_ear_morphology3.39002423
5MP0005377_hearing/vestibular/ear_phenot3.27059588
6MP0003878_abnormal_ear_physiology3.27059588
7MP0002638_abnormal_pupillary_reflex2.85503878
8MP0002166_altered_tumor_susceptibility2.84557574
9MP0003303_peritoneal_inflammation2.58756999
10MP0001800_abnormal_humoral_immune2.40185070
11MP0003879_abnormal_hair_cell2.19430207
12MP0002822_catalepsy2.15023270
13MP0003436_decreased_susceptibility_to2.09034961
14MP0002006_tumorigenesis2.06877239
15MP0002723_abnormal_immune_serum2.04516684
16MP0005025_abnormal_response_to2.03106064
17MP0005410_abnormal_fertilization1.96075144
18MP0002420_abnormal_adaptive_immunity1.92673885
19MP0002419_abnormal_innate_immunity1.91495985
20MP0001819_abnormal_immune_cell1.90615826
21MP0002452_abnormal_antigen_presenting1.90310896
22MP0005000_abnormal_immune_tolerance1.89754590
23MP0005464_abnormal_platelet_physiology1.85477533
24MP0001790_abnormal_immune_system1.84217957
25MP0005387_immune_system_phenotype1.84217957
26MP0009785_altered_susceptibility_to1.80333792
27MP0004742_abnormal_vestibular_system1.79490344
28MP0002396_abnormal_hematopoietic_system1.77947037
29MP0002148_abnormal_hypersensitivity_rea1.76789721
30MP0005360_urolithiasis1.73214781
31MP0006082_CNS_inflammation1.72321572
32MP0000716_abnormal_immune_system1.68697862
33MP0002138_abnormal_hepatobiliary_system1.67416460
34MP0003646_muscle_fatigue1.67383923
35MP0003172_abnormal_lysosome_physiology1.66760330
36MP0002933_joint_inflammation1.65589366
37MP0002398_abnormal_bone_marrow1.61556239
38MP0004808_abnormal_hematopoietic_stem1.56096560
39MP0001485_abnormal_pinna_reflex1.54617613
40MP0001873_stomach_inflammation1.47654051
41MP0001764_abnormal_homeostasis1.42484903
42MP0001845_abnormal_inflammatory_respons1.38765173
43MP0003763_abnormal_thymus_physiology1.38439458
44MP0009764_decreased_sensitivity_to1.37138518
45MP0002429_abnormal_blood_cell1.33289013
46MP0000689_abnormal_spleen_morphology1.32577393
47MP0010155_abnormal_intestine_physiology1.24243883
48MP0001545_abnormal_hematopoietic_system1.22031871
49MP0005397_hematopoietic_system_phenotyp1.22031871
50MP0004142_abnormal_muscle_tone1.21134792
51MP0000372_irregular_coat_pigmentation1.20898277
52MP0002722_abnormal_immune_system1.18003906
53MP0008995_early_reproductive_senescence1.17990961
54MP0000703_abnormal_thymus_morphology1.17546522
55MP0005058_abnormal_lysosome_morphology1.16896768
56MP0003866_abnormal_defecation1.16645092
57MP0001486_abnormal_startle_reflex1.12713252
58MP0009333_abnormal_splenocyte_physiolog1.09573716
59MP0003828_pulmonary_edema1.07978864
60MP0002009_preneoplasia1.07410612
61MP0008877_abnormal_DNA_methylation1.02723059
62MP0005551_abnormal_eye_electrophysiolog0.99161959
63MP0003950_abnormal_plasma_membrane0.99072512
64MP0001501_abnormal_sleep_pattern0.99046978
65MP0008469_abnormal_protein_level0.98706268
66MP0003221_abnormal_cardiomyocyte_apopto0.95078283
67MP0001853_heart_inflammation0.91732793
68MP0005645_abnormal_hypothalamus_physiol0.91212488
69MP0003724_increased_susceptibility_to0.89292370
70MP0010307_abnormal_tumor_latency0.87498066
71MP0003786_premature_aging0.84760138
72MP0002876_abnormal_thyroid_physiology0.84087171
73MP0001929_abnormal_gametogenesis0.82006344
74MP0003252_abnormal_bile_duct0.81133578
75MP0008875_abnormal_xenobiotic_pharmacok0.78065044
76MP0001502_abnormal_circadian_rhythm0.77278989
77MP0002405_respiratory_system_inflammati0.76747100
78MP0001533_abnormal_skeleton_physiology0.75808383
79MP0002693_abnormal_pancreas_physiology0.73015982
80MP0005075_abnormal_melanosome_morpholog0.71351606
81MP0001986_abnormal_taste_sensitivity0.71006567
82MP0005310_abnormal_salivary_gland0.68795963
83MP0004084_abnormal_cardiac_muscle0.67153415
84MP0008775_abnormal_heart_ventricle0.65906152
85MP0004043_abnormal_pH_regulation0.65680691
86MP0001663_abnormal_digestive_system0.65366745
87MP0001919_abnormal_reproductive_system0.64746998
88MP0003698_abnormal_male_reproductive0.64401817
89MP0001440_abnormal_grooming_behavior0.64097196
90MP0002332_abnormal_exercise_endurance0.63495344
91MP0005253_abnormal_eye_physiology0.61389214
92MP0008961_abnormal_basal_metabolism0.61323986
93MP0004145_abnormal_muscle_electrophysio0.60738691
94MP0008872_abnormal_physiological_respon0.59223330
95MP0001765_abnormal_ion_homeostasis0.57875559
96MP0002998_abnormal_bone_remodeling0.56951666
97MP0004782_abnormal_surfactant_physiolog0.55357633
98MP0001664_abnormal_digestion0.54548968
99MP0003806_abnormal_nucleotide_metabolis0.53838367
100MP0001348_abnormal_lacrimal_gland0.53296974

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)8.47620236
2Chronic otitis media (HP:0000389)8.24770504
3Nasal polyposis (HP:0100582)5.68693954
4Chronic sinusitis (HP:0011109)5.10159025
5Muscle fiber atrophy (HP:0100295)4.89811152
6Recurrent bronchitis (HP:0002837)4.75950329
7Abnormality of the nasal mucosa (HP:0000433)4.64586347
8Abnormality of macular pigmentation (HP:0008002)4.09355936
9Large eyes (HP:0001090)3.84861073
10Reduced subcutaneous adipose tissue (HP:0003758)3.81518434
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.77625070
12Flat capital femoral epiphysis (HP:0003370)3.70851596
13Large for gestational age (HP:0001520)3.60388448
14Hypergammaglobulinemia (HP:0010702)3.55447715
15Atrioventricular block (HP:0001678)3.35781224
16Increased cerebral lipofuscin (HP:0011813)3.31920121
17Vacuolated lymphocytes (HP:0001922)3.21248943
18Bronchitis (HP:0012387)3.14443623
19Basal ganglia calcification (HP:0002135)3.09474597
20Encephalitis (HP:0002383)3.00311429
21Stomatitis (HP:0010280)2.93098552
22Abnormality of the fingertips (HP:0001211)2.89451241
23Renal cortical cysts (HP:0000803)2.83962535
24Thrombocytosis (HP:0001894)2.82247978
25Abnormality of B cell number (HP:0010975)2.78788710
26Increased serum ferritin (HP:0003281)2.77219115
27Abolished electroretinogram (ERG) (HP:0000550)2.76652357
28Shawl scrotum (HP:0000049)2.72025611
29Hypoplasia of the thymus (HP:0000778)2.70875207
30Achilles tendon contracture (HP:0001771)2.67587351
31Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.64932465
32B lymphocytopenia (HP:0010976)2.63387249
33IgG deficiency (HP:0004315)2.62635834
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.62104875
35Chronic mucocutaneous candidiasis (HP:0002728)2.61557812
36Recurrent cutaneous fungal infections (HP:0011370)2.61557812
37Erythema (HP:0010783)2.59751562
38Hypertriglyceridemia (HP:0002155)2.55853231
39Myositis (HP:0100614)2.53336111
40Meningitis (HP:0001287)2.51288622
41Abnormality of T cell physiology (HP:0011840)2.46640238
42Severe visual impairment (HP:0001141)2.44893125
43Tinnitus (HP:0000360)2.41689651
44Acute hepatic failure (HP:0006554)2.39643644
45Hemiplegia (HP:0002301)2.39504579
46Panhypogammaglobulinemia (HP:0003139)2.38923636
47Abnormality of the Achilles tendon (HP:0005109)2.38559835
48Respiratory difficulties (HP:0002880)2.37360272
49Decreased circulating renin level (HP:0003351)2.35434446
50Asymmetric septal hypertrophy (HP:0001670)2.34031898
51Severe combined immunodeficiency (HP:0004430)2.34001160
52Abnormality of transition element cation homeostasis (HP:0011030)2.31595546
53Clubbing of toes (HP:0100760)2.31343775
54Bilateral sensorineural hearing impairment (HP:0008619)2.30292926
55Abnormality of macrophages (HP:0004311)2.27229323
56Increased IgM level (HP:0003496)2.26336916
57Hypoproteinemia (HP:0003075)2.24724935
58Large earlobe (HP:0009748)2.24663862
59Esophageal atresia (HP:0002032)2.21489828
60Recurrent viral infections (HP:0004429)2.19139593
61Heart block (HP:0012722)2.18100768
62Abnormality of iron homeostasis (HP:0011031)2.17617340
63Skin rash (HP:0000988)2.17183031
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.16839976
65Recurrent fungal infections (HP:0002841)2.16779358
66Agammaglobulinemia (HP:0004432)2.07546766
67Abnormality of the prostate (HP:0008775)2.06006164
68Retrobulbar optic neuritis (HP:0100654)2.04289052
69Optic neuritis (HP:0100653)2.04289052
70Abnormality of T cells (HP:0002843)1.99940230
71Microcytic anemia (HP:0001935)1.98667990
72Bronchiectasis (HP:0002110)1.98078095
73Hemoptysis (HP:0002105)1.97579791
74Dry hair (HP:0011359)1.97437844
75Emphysema (HP:0002097)1.97341657
76Anhidrosis (HP:0000970)1.96709231
77Trismus (HP:0000211)1.96241476
78Abnormal atrioventricular conduction (HP:0005150)1.84541071
79Patchy hypopigmentation of hair (HP:0011365)1.82200320
80Pulmonary infiltrates (HP:0002113)1.79172636
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77124184
82Abnormality of the renal cortex (HP:0011035)1.75914090
83T lymphocytopenia (HP:0005403)1.75279072
84Joint contractures involving the joints of the feet (HP:0100492)1.73954205
85Flexion contracture of toe (HP:0005830)1.73954205
863-Methylglutaconic aciduria (HP:0003535)1.73882575
87Constricted visual fields (HP:0001133)1.71904101
88Combined immunodeficiency (HP:0005387)1.71506070
89Conical tooth (HP:0000698)1.70907587
90Vasculitis (HP:0002633)1.68930192
91Neurodegeneration (HP:0002180)1.68658063
92Dysostosis multiplex (HP:0000943)1.67410495
93IgM deficiency (HP:0002850)1.66217962
94Visual hallucinations (HP:0002367)1.64573459
95Urticaria (HP:0001025)1.62920649
96Abnormality of the basal ganglia (HP:0002134)1.62215939
97Abnormality of T cell number (HP:0011839)1.62020225
98Attenuation of retinal blood vessels (HP:0007843)1.61995744
99Granulocytopenia (HP:0001913)1.61037489
100Abnormality of binocular vision (HP:0011514)1.59601528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MOS4.18416904
2GRK73.68139576
3TAOK33.43698945
4MAP3K133.10081558
5TGFBR22.99567207
6TEC2.84160537
7KIT2.81591138
8PLK42.70372543
9ITK2.64372427
10MAP4K22.40873709
11MAP3K142.13722154
12STK102.07052468
13CDK81.99837255
14INSRR1.83195858
15FES1.67670491
16SIK31.67483060
17TXK1.66902758
18SIK21.66521803
19GRK51.66208954
20SYK1.65977333
21MARK31.64090234
22HCK1.57982593
23FLT31.52692241
24TBK11.49545239
25PIK3CG1.48775323
26KSR21.45044185
27NUAK11.44342679
28BTK1.44062193
29IKBKE1.37236464
30MAP3K101.35355890
31STK161.31250767
32IKBKB1.29022784
33RAF11.23373956
34LCK1.22777563
35RIPK41.14022701
36PDK11.13976238
37GRK61.12702071
38LYN1.12654793
39CDK41.09065352
40ERN11.08190885
41BMPR1B1.07731078
42SIK11.04296879
43PRPF4B1.02845631
44EIF2AK21.01314779
45CCNB11.00591049
46BLK0.95818315
47EIF2AK30.95068734
48MAP4K10.92981968
49PAK60.92685927
50CDK90.91517504
51CSF1R0.91103818
52MAP3K70.90836994
53ADRBK20.87904889
54ZAP700.87574398
55IRAK40.86300066
56BCKDK0.86082722
57TNK20.85452573
58JAK30.84059527
59CDK190.82887374
60ZAK0.82807758
61PRKCQ0.73092173
62MAPK70.72946155
63TLK10.69832367
64MAPK120.69730667
65PASK0.68484004
66ADRBK10.68385667
67MAPKAPK50.67980558
68ABL10.67134260
69CDK60.60548300
70CDK30.60419091
71JAK10.60297128
72ARAF0.59465075
73PIM10.58450228
74JAK20.58235806
75KSR10.56315417
76BRD40.54565964
77FRK0.53748657
78TGFBR10.53224972
79MUSK0.51800420
80NEK60.50227979
81TIE10.48463526
82DYRK1B0.48389105
83PDPK10.47283998
84MAP2K60.46807163
85TYK20.46555639
86MATK0.42651272
87PRKCD0.41955493
88LATS10.41761197
89IGF1R0.41216914
90MAPKAPK20.40838657
91LRRK20.39483718
92MAP2K20.37527090
93MARK20.36395979
94CLK10.35132380
95CHUK0.32659057
96TRPM70.32291847
97MAPK130.31394454
98MAP3K90.30320147
99MAPK110.30131277
100BMPR20.27671824

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046724.69413231
2Asthma_Homo sapiens_hsa053104.05739746
3Primary immunodeficiency_Homo sapiens_hsa053403.75092767
4Allograft rejection_Homo sapiens_hsa053303.38823960
5Graft-versus-host disease_Homo sapiens_hsa053323.28808613
6Autoimmune thyroid disease_Homo sapiens_hsa053203.27259688
7Type I diabetes mellitus_Homo sapiens_hsa049402.78034253
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42557090
9Antigen processing and presentation_Homo sapiens_hsa046122.33480952
10B cell receptor signaling pathway_Homo sapiens_hsa046622.02054148
11Herpes simplex infection_Homo sapiens_hsa051681.98398228
12Viral myocarditis_Homo sapiens_hsa054161.96600401
13ABC transporters_Homo sapiens_hsa020101.87021567
14Other glycan degradation_Homo sapiens_hsa005111.72699208
15Leishmaniasis_Homo sapiens_hsa051401.72298236
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65780069
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61424826
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55173006
19Rheumatoid arthritis_Homo sapiens_hsa053231.54905010
20Hematopoietic cell lineage_Homo sapiens_hsa046401.47737591
21Ribosome_Homo sapiens_hsa030101.46466717
22Staphylococcus aureus infection_Homo sapiens_hsa051501.42374372
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.28979106
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27397246
25Measles_Homo sapiens_hsa051621.23677737
26Caffeine metabolism_Homo sapiens_hsa002321.23494804
27Olfactory transduction_Homo sapiens_hsa047401.22212064
28Phototransduction_Homo sapiens_hsa047441.21968343
29Acute myeloid leukemia_Homo sapiens_hsa052211.21958269
30Dorso-ventral axis formation_Homo sapiens_hsa043201.19563828
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15480992
32T cell receptor signaling pathway_Homo sapiens_hsa046601.14376792
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14300946
34Linoleic acid metabolism_Homo sapiens_hsa005911.12853484
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.09370578
36Influenza A_Homo sapiens_hsa051641.08856615
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07573466
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06922020
39Salivary secretion_Homo sapiens_hsa049701.05901420
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05750213
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96431526
42Tuberculosis_Homo sapiens_hsa051520.90540393
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.84814877
44Basal transcription factors_Homo sapiens_hsa030220.82761387
45Peroxisome_Homo sapiens_hsa041460.79037182
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.78579085
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76865323
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76380838
49Osteoclast differentiation_Homo sapiens_hsa043800.76155644
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72034843
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70051441
52One carbon pool by folate_Homo sapiens_hsa006700.68707299
53Toxoplasmosis_Homo sapiens_hsa051450.68138920
54Histidine metabolism_Homo sapiens_hsa003400.66590072
55Phagosome_Homo sapiens_hsa041450.65693502
56Hepatitis B_Homo sapiens_hsa051610.65357373
57Glycerolipid metabolism_Homo sapiens_hsa005610.65218472
58Ether lipid metabolism_Homo sapiens_hsa005650.65173907
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63864537
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62608328
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62053746
62Regulation of autophagy_Homo sapiens_hsa041400.60430165
63Arachidonic acid metabolism_Homo sapiens_hsa005900.59568352
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.57973955
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57587125
66Cardiac muscle contraction_Homo sapiens_hsa042600.54536213
67Lysosome_Homo sapiens_hsa041420.52592726
68beta-Alanine metabolism_Homo sapiens_hsa004100.51368034
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48253952
70Legionellosis_Homo sapiens_hsa051340.44794439
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44452373
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43498812
73Dilated cardiomyopathy_Homo sapiens_hsa054140.42170265
74Morphine addiction_Homo sapiens_hsa050320.41460647
75Tryptophan metabolism_Homo sapiens_hsa003800.40609351
76Retinol metabolism_Homo sapiens_hsa008300.40419935
77Nitrogen metabolism_Homo sapiens_hsa009100.39516914
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38755020
79Homologous recombination_Homo sapiens_hsa034400.37627397
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36977685
81Apoptosis_Homo sapiens_hsa042100.36842460
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36492019
83N-Glycan biosynthesis_Homo sapiens_hsa005100.36430150
84Systemic lupus erythematosus_Homo sapiens_hsa053220.36298331
85Pancreatic secretion_Homo sapiens_hsa049720.34240084
86Protein export_Homo sapiens_hsa030600.32683508
87TNF signaling pathway_Homo sapiens_hsa046680.32427868
88Taste transduction_Homo sapiens_hsa047420.32246753
89HTLV-I infection_Homo sapiens_hsa051660.32048524
90Gastric acid secretion_Homo sapiens_hsa049710.31987056
91Base excision repair_Homo sapiens_hsa034100.31974560
92Calcium signaling pathway_Homo sapiens_hsa040200.31166291
93Epstein-Barr virus infection_Homo sapiens_hsa051690.30793617
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28484487
95RNA polymerase_Homo sapiens_hsa030200.25065659
96Sulfur metabolism_Homo sapiens_hsa009200.23697059
97Chemokine signaling pathway_Homo sapiens_hsa040620.22500496
98Inositol phosphate metabolism_Homo sapiens_hsa005620.22419034
99RNA degradation_Homo sapiens_hsa030180.22322573
100Platelet activation_Homo sapiens_hsa046110.21571360

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