ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	9.17923906
2	fusion of sperm to egg plasma membrane (GO:0007342)	9.04780138
3	regulation of activation of Janus kinase activity (GO:0010533)	8.31945970
4	response to pheromone (GO:0019236)	8.24166447
5	growth hormone receptor signaling pathway (GO:0060396)	7.83834219
6	chromosome condensation (GO:0030261)	7.55014541
7	DNA packaging (GO:0006323)	7.33772867
8	microtubule depolymerization (GO:0007019)	7.33263502
9	spermatid nucleus differentiation (GO:0007289)	7.15304982
10	sperm capacitation (GO:0048240)	7.10643231
11	spermatid development (GO:0007286)	7.01527342
12	protein targeting to Golgi (GO:0000042)	6.93943299
13	cellular response to growth hormone stimulus (GO:0071378)	6.92356560
14	plasma membrane fusion (GO:0045026)	6.75786422
15	establishment of protein localization to Golgi (GO:0072600)	6.63415056
16	centriole replication (GO:0007099)	6.51412865
17	multicellular organism reproduction (GO:0032504)	6.49099766
18	protein polyglutamylation (GO:0018095)	6.42564062
19	centriole assembly (GO:0098534)	6.40800360
20	single strand break repair (GO:0000012)	6.39288711
21	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.37505759
22	sperm-egg recognition (GO:0035036)	6.27060367
23	microtubule severing (GO:0051013)	6.17565754
24	microtubule polymerization or depolymerization (GO:0031109)	6.03714891
25	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.79308596
26	reproduction (GO:0000003)	5.74832049
27	rRNA methylation (GO:0031167)	5.60086917
28	spermatogenesis (GO:0007283)	5.45462033
29	regulation of centriole replication (GO:0046599)	5.45445186
30	male gamete generation (GO:0048232)	5.44033104
31	phosphatidylethanolamine metabolic process (GO:0046337)	5.31185444
32	binding of sperm to zona pellucida (GO:0007339)	5.21789837
33	calcium ion-dependent exocytosis (GO:0017156)	5.21781946
34	cell-cell recognition (GO:0009988)	5.17363329
35	negative regulation of inclusion body assembly (GO:0090084)	5.03262914
36	gamete generation (GO:0007276)	4.98109354
37	regulation of transcription involved in cell fate commitment (GO:0060850)	4.92509201
38	axonemal dynein complex assembly (GO:0070286)	4.75763281
39	regulation of cilium movement (GO:0003352)	4.73504410
40	motile cilium assembly (GO:0044458)	4.71081721
41	protein localization to Golgi apparatus (GO:0034067)	4.66734912
42	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.64687806
43	regulation of Rab GTPase activity (GO:0032313)	4.62630327
44	positive regulation of Rab GTPase activity (GO:0032851)	4.62630327
45	sexual reproduction (GO:0019953)	4.57630917
46	single fertilization (GO:0007338)	4.49862157
47	rRNA modification (GO:0000154)	4.43612787
48	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	4.42895502
49	seminiferous tubule development (GO:0072520)	4.20165855
50	adult feeding behavior (GO:0008343)	4.18313911
51	multicellular organismal reproductive process (GO:0048609)	4.07942105
52	musculoskeletal movement (GO:0050881)	4.02910129
53	multicellular organismal movement (GO:0050879)	4.02910129
54	response to growth hormone (GO:0060416)	4.01561352
55	nucleus organization (GO:0006997)	3.99363919
56	RNA destabilization (GO:0050779)	3.97578992
57	germ cell development (GO:0007281)	3.93134810
58	regulation of feeding behavior (GO:0060259)	3.92864085
59	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.91664480
60	epithelial cilium movement (GO:0003351)	3.88116908
61	cilium or flagellum-dependent cell motility (GO:0001539)	3.84660268
62	fertilization (GO:0009566)	3.75309319
63	cell wall macromolecule metabolic process (GO:0044036)	3.70434318
64	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.68028367
65	cellular ketone body metabolic process (GO:0046950)	3.67497774
66	positive regulation of receptor internalization (GO:0002092)	3.66371662
67	peptidyl-threonine dephosphorylation (GO:0035970)	3.65932284
68	male meiosis I (GO:0007141)	3.62960404
69	nuclear pore complex assembly (GO:0051292)	3.60771806
70	positive regulation of action potential (GO:0045760)	3.54223281
71	regulation of inclusion body assembly (GO:0090083)	3.53119437
72	microtubule nucleation (GO:0007020)	3.51452123
73	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	3.29046299
74	chromatin silencing (GO:0006342)	3.26848377
75	glomerular visceral epithelial cell development (GO:0072015)	3.26483660
76	opioid receptor signaling pathway (GO:0038003)	3.25822701
77	ketone body metabolic process (GO:1902224)	3.19966798
78	cellular response to pH (GO:0071467)	3.18070096
79	cell wall macromolecule catabolic process (GO:0016998)	3.16113580
80	cilium movement (GO:0003341)	3.15291668
81	Golgi to endosome transport (GO:0006895)	3.13010039
82	regulation of histone H3-K27 methylation (GO:0061085)	3.11602664
83	organic cation transport (GO:0015695)	3.10129517
84	JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)	3.09753795
85	glomerular epithelial cell development (GO:0072310)	3.01378934
86	regulation of microtubule-based movement (GO:0060632)	2.97854425
87	homeostasis of number of cells within a tissue (GO:0048873)	2.96448661
88	meiosis I (GO:0007127)	2.88035183
89	response to acidic pH (GO:0010447)	2.84419004
90	regulation of centrosome duplication (GO:0010824)	2.82884813
91	membrane protein intracellular domain proteolysis (GO:0031293)	2.72133009
92	centrosome duplication (GO:0051298)	2.70487553
93	multicellular organismal development (GO:0007275)	2.67900745
94	negative regulation of histone methylation (GO:0031061)	2.67256993
95	protein complex localization (GO:0031503)	2.65033979
96	male meiosis (GO:0007140)	2.64729003
97	DNA conformation change (GO:0071103)	2.63643174
98	nuclear pore organization (GO:0006999)	2.63241023
99	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.62579259
100	sperm motility (GO:0030317)	10.1888973

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.23680728
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.27433927
3	FUS_26573619_Chip-Seq_HEK293_Human	2.59789191
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.48447777
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.46984540
6	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.46984540
7	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.42746992
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.37640879
9	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.28262139
10	DROSHA_22980978_ChIP-Seq_HELA_Human	2.27124244
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20890830
12	CBP_20019798_ChIP-Seq_JUKART_Human	2.18636980
13	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.18636980
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.06986354
15	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.05840581
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04178010
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01933818
18	RAC3_21632823_ChIP-Seq_H3396_Human	1.89213873
19	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.87596955
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.86284548
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.83199045
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.80822658
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.80696528
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.78066260
25	AR_25329375_ChIP-Seq_VCAP_Human	1.75813537
26	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.74017049
27	ERA_21632823_ChIP-Seq_H3396_Human	1.71472865
28	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.71364742
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.67382147
30	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.65692117
31	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.64170717
32	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.61493874
33	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.56209550
34	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.50621182
35	NANOG_20526341_ChIP-Seq_ESCs_Human	1.48869721
36	TAF2_19829295_ChIP-Seq_ESCs_Human	1.47784786
37	P300_19829295_ChIP-Seq_ESCs_Human	1.45886080
38	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.45751682
39	NFYB_21822215_ChIP-Seq_K562_Human	1.44969545
40	ERG_20517297_ChIP-Seq_VCAP_Human	1.43238962
41	ETV1_20927104_ChIP-Seq_GIST48_Human	1.41345071
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.40585111
43	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.38886693
44	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.38422865
45	STAT3_23295773_ChIP-Seq_U87_Human	1.36633485
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36066212
47	STAT1_20625510_ChIP-Seq_HELA_Human	1.35899541
48	RBPJ_21746931_ChIP-Seq_IB4_Human	1.35512265
49	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.34815492
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34518250
51	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.34226473
52	CTCF_27219007_Chip-Seq_Bcells_Human	1.32606424
53	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.31866900
54	SMC4_20622854_ChIP-Seq_HELA_Human	1.31607964
55	TBL1_22424771_ChIP-Seq_293T_Human	1.26982804
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25128071
57	OCT4_20526341_ChIP-Seq_ESCs_Human	1.24590457
58	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.24437445
59	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.23556189
60	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22755643
61	NFYA_21822215_ChIP-Seq_K562_Human	1.22403964
62	PHF8_20622853_ChIP-Seq_HELA_Human	1.21425547
63	AHR_22903824_ChIP-Seq_MCF-7_Human	1.21341632
64	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.19797669
65	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.19577450
66	BCL6_27268052_Chip-Seq_Bcells_Human	1.19056425
67	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17022842
68	P300_27268052_Chip-Seq_Bcells_Human	1.16223373
69	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.16099764
70	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.15779390
71	PHF8_20622854_ChIP-Seq_HELA_Human	1.13836470
72	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.13236635
73	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.13157651
74	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12324150
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12306749
76	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.11886277
77	GATA3_26560356_Chip-Seq_TH1_Human	1.11183415
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11064030
79	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.10815635
80	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.10277320
81	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.09645302
82	SMRT_27268052_Chip-Seq_Bcells_Human	1.08953004
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08580281
84	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.08181918
85	P68_20966046_ChIP-Seq_HELA_Human	1.07698271
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06137887
87	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.05986410
88	P53_21459846_ChIP-Seq_SAOS-2_Human	1.05800343
89	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05746949
90	MYC_19829295_ChIP-Seq_ESCs_Human	1.04845756
91	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.04146526
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03989666
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03989666
94	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.02393988
95	GBX2_23144817_ChIP-Seq_PC3_Human	1.02122678
96	E2F1_20622854_ChIP-Seq_HELA_Human	1.02076297
97	CTCF_20526341_ChIP-Seq_ESCs_Human	1.01847274
98	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.99992597
99	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99518579
100	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.99237840

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	5.45123552
2	MP0005670_abnormal_white_adipose	4.57059067
3	MP0001348_abnormal_lacrimal_gland	4.48032489
4	MP0003698_abnormal_male_reproductive	3.89502563
5	MP0003878_abnormal_ear_physiology	3.69545485
6	MP0005377_hearing/vestibular/ear_phenot	3.69545485
7	MP0001929_abnormal_gametogenesis	3.47385989
8	MP0001661_extended_life_span	2.75741773
9	MP0008057_abnormal_DNA_replication	2.73916323
10	MP0002161_abnormal_fertility/fecundity	2.19001402
11	MP0006292_abnormal_olfactory_placode	2.11889044
12	MP0005410_abnormal_fertilization	10.2907206
13	MP0000678_abnormal_parathyroid_gland	1.91729828
14	MP0005379_endocrine/exocrine_gland_phen	1.88425220
15	MP0002822_catalepsy	1.84531308
16	MP0005310_abnormal_salivary_gland	1.73263586
17	MP0002210_abnormal_sex_determination	1.72540402
18	MP0003880_abnormal_central_pattern	1.69314266
19	MP0003718_maternal_effect	1.68304513
20	MP0003646_muscle_fatigue	1.52333145
21	MP0003077_abnormal_cell_cycle	1.35398716
22	MP0002735_abnormal_chemical_nociception	1.33040759
23	MP0002234_abnormal_pharynx_morphology	1.32861958
24	MP0002132_abnormal_respiratory_system	1.32621397
25	MP0008877_abnormal_DNA_methylation	1.30923795
26	MP0005423_abnormal_somatic_nervous	1.30358832
27	MP0000653_abnormal_sex_gland	1.29394718
28	MP0000516_abnormal_urinary_system	1.22872182
29	MP0005367_renal/urinary_system_phenotyp	1.22872182
30	MP0002282_abnormal_trachea_morphology	1.22552001
31	MP0001485_abnormal_pinna_reflex	1.22370031
32	MP0001145_abnormal_male_reproductive	1.18708390
33	MP0001486_abnormal_startle_reflex	1.16480713
34	MP0005535_abnormal_body_temperature	1.15604489
35	MP0001765_abnormal_ion_homeostasis	1.13288556
36	MP0002249_abnormal_larynx_morphology	1.13106555
37	MP0001968_abnormal_touch/_nociception	1.09761206
38	MP0005666_abnormal_adipose_tissue	1.09463440
39	MP0004742_abnormal_vestibular_system	1.08893710
40	MP0005253_abnormal_eye_physiology	1.05604907
41	MP0003959_abnormal_lean_body	1.01824536
42	MP0009115_abnormal_fat_cell	1.01536205
43	MP0000534_abnormal_ureter_morphology	0.97138893
44	MP0001905_abnormal_dopamine_level	0.87074119
45	MP0002928_abnormal_bile_duct	0.85142418
46	MP0001963_abnormal_hearing_physiology	0.83348797
47	MP0009697_abnormal_copulation	0.82988222
48	MP0005645_abnormal_hypothalamus_physiol	0.82617664
49	MP0001529_abnormal_vocalization	0.81114085
50	MP0005395_other_phenotype	0.80379915
51	MP0003693_abnormal_embryo_hatching	0.79454635
52	MP0002067_abnormal_sensory_capabilities	0.79331457
53	MP0005551_abnormal_eye_electrophysiolog	0.76590581
54	MP0003137_abnormal_impulse_conducting	0.75073968
55	MP0001666_abnormal_nutrient_absorption	0.74868366
56	MP0004085_abnormal_heartbeat	0.74151112
57	MP0000049_abnormal_middle_ear	0.73086615
58	MP0004142_abnormal_muscle_tone	0.71392222
59	MP0003122_maternal_imprinting	0.69240369
60	MP0005391_vision/eye_phenotype	0.68913885
61	MP0005375_adipose_tissue_phenotype	0.68549088
62	MP0008961_abnormal_basal_metabolism	0.68227678
63	MP0008995_early_reproductive_senescence	0.66673779
64	MP0004782_abnormal_surfactant_physiolog	0.65059038
65	MP0002572_abnormal_emotion/affect_behav	0.63056580
66	MP0001293_anophthalmia	0.62643128
67	MP0004859_abnormal_synaptic_plasticity	0.62259467
68	MP0001286_abnormal_eye_development	0.59281547
69	MP0002127_abnormal_cardiovascular_syste	0.59171927
70	MP0006072_abnormal_retinal_apoptosis	0.58446141
71	MP0009745_abnormal_behavioral_response	0.58201952
72	MP0000026_abnormal_inner_ear	0.57437510
73	MP0003011_delayed_dark_adaptation	0.56828485
74	MP0004957_abnormal_blastocyst_morpholog	0.56788962
75	MP0003635_abnormal_synaptic_transmissio	0.56730472
76	MP0005248_abnormal_Harderian_gland	0.55364777
77	MP0003879_abnormal_hair_cell	0.54944094
78	MP0002837_dystrophic_cardiac_calcinosis	0.54942601
79	MP0008789_abnormal_olfactory_epithelium	0.53920836
80	MP0002184_abnormal_innervation	0.53918344
81	MP0009053_abnormal_anal_canal	0.52859147
82	MP0006276_abnormal_autonomic_nervous	0.52843081
83	MP0000955_abnormal_spinal_cord	0.52521174
84	MP0002229_neurodegeneration	0.51422666
85	MP0000569_abnormal_digit_pigmentation	0.49560344
86	MP0002557_abnormal_social/conspecific_i	0.48827012
87	MP0003948_abnormal_gas_homeostasis	0.46792770
88	MP0004233_abnormal_muscle_weight	0.46763140
89	MP0005266_abnormal_metabolism	0.46646325
90	MP0001440_abnormal_grooming_behavior	0.46401217
91	MP0008875_abnormal_xenobiotic_pharmacok	0.46270631
92	MP0005448_abnormal_energy_balance	0.45361474
93	MP0008872_abnormal_physiological_respon	0.44865343
94	MP0000681_abnormal_thyroid_gland	0.44117293
95	MP0003699_abnormal_female_reproductive	0.43044323
96	MP0000631_abnormal_neuroendocrine_gland	0.41270892
97	MP0001970_abnormal_pain_threshold	0.41161920
98	MP0000383_abnormal_hair_follicle	0.40699626
99	MP0002069_abnormal_eating/drinking_beha	0.40075555
100	MP0003119_abnormal_digestive_system	0.39104401

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	6.47487049
2	Bony spicule pigmentary retinopathy (HP:0007737)	5.20646425
3	Chronic hepatic failure (HP:0100626)	5.10006099
4	Attenuation of retinal blood vessels (HP:0007843)	4.87409640
5	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.63931427
6	Tubulointerstitial nephritis (HP:0001970)	4.60341848
7	Hyperkalemia (HP:0002153)	4.42303029
8	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.40781687
9	Absent/shortened dynein arms (HP:0200106)	4.40781687
10	Resting tremor (HP:0002322)	4.40301311
11	Asymmetric septal hypertrophy (HP:0001670)	4.17853661
12	Male infertility (HP:0003251)	4.04643021
13	Abnormality of macular pigmentation (HP:0008002)	3.95124671
14	Growth hormone deficiency (HP:0000824)	3.77433686
15	Infertility (HP:0000789)	3.52650603
16	Cone-rod dystrophy (HP:0000548)	3.50947932
17	Menstrual irregularities (HP:0000858)	3.49529431
18	Impulsivity (HP:0100710)	3.43029409
19	Abnormal rod and cone electroretinograms (HP:0008323)	3.40300802
20	Progressive sensorineural hearing impairment (HP:0000408)	3.28539645
21	Enlarged epiphyses (HP:0010580)	3.25923119
22	Truncal obesity (HP:0001956)	3.25377177
23	Neoplasm of the heart (HP:0100544)	3.23753855
24	Nasal polyposis (HP:0100582)	3.15694950
25	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.14611465
26	Abnormal respiratory motile cilium morphology (HP:0005938)	3.14014403
27	Abnormal respiratory epithelium morphology (HP:0012253)	3.14014403
28	Abnormal ciliary motility (HP:0012262)	3.10013796
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.09775522
30	Abnormal respiratory motile cilium physiology (HP:0012261)	3.08525914
31	Nephronophthisis (HP:0000090)	3.02799661
32	Renovascular hypertension (HP:0100817)	2.98570073
33	Severe short stature (HP:0003510)	2.88729596
34	Potter facies (HP:0002009)	2.85223735
35	Facial shape deformation (HP:0011334)	2.85223735
36	Abnormal spermatogenesis (HP:0008669)	2.85127698
37	Bell-shaped thorax (HP:0001591)	2.81447669
38	Hypoplastic ischia (HP:0003175)	2.72966207
39	Postural instability (HP:0002172)	2.63428802
40	Amelogenesis imperfecta (HP:0000705)	2.56743329
41	Abnormality of the renal medulla (HP:0100957)	2.55386262
42	Intellectual disability, moderate (HP:0002342)	2.46777650
43	Hypoplasia of the thymus (HP:0000778)	2.45561356
44	Abnormal urine output (HP:0012590)	2.44368900
45	Abnormality of the ischium (HP:0003174)	2.42841792
46	Polydipsia (HP:0001959)	2.42686882
47	Abnormal drinking behavior (HP:0030082)	2.42686882
48	Genetic anticipation (HP:0003743)	2.41768166
49	Insulin-resistant diabetes mellitus (HP:0000831)	2.41063728
50	Abnormality of potassium homeostasis (HP:0011042)	2.39153570
51	Optic nerve hypoplasia (HP:0000609)	2.34454350
52	Abnormality of the nasal mucosa (HP:0000433)	2.32935551
53	Short 4th metacarpal (HP:0010044)	2.32684758
54	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.32684758
55	Azoospermia (HP:0000027)	2.28098875
56	Subcapsular cataract (HP:0000523)	2.24360197
57	Cerebellar dysplasia (HP:0007033)	2.21936303
58	Hypoalphalipoproteinemia (HP:0003233)	2.20264309
59	Stage 5 chronic kidney disease (HP:0003774)	2.19088766
60	Tubulointerstitial abnormality (HP:0001969)	2.18668159
61	Portal hypertension (HP:0001409)	2.16253111
62	Progressive hearing impairment (HP:0001730)	2.14430636
63	Constricted visual fields (HP:0001133)	2.12768939
64	Type II diabetes mellitus (HP:0005978)	2.12248799
65	Progressive cerebellar ataxia (HP:0002073)	2.11015658
66	Termporal pattern (HP:0011008)	2.08556232
67	Insidious onset (HP:0003587)	2.08556232
68	Fatigable weakness (HP:0003473)	2.06557864
69	Abnormality of the neuromuscular junction (HP:0003398)	2.06557864
70	Polyuria (HP:0000103)	2.05749335
71	Abnormality of the hepatic vasculature (HP:0006707)	2.04297413
72	Hypolipoproteinemia (HP:0010981)	2.03708373
73	Abnormality of renal excretion (HP:0011036)	2.03641457
74	Photophobia (HP:0000613)	2.02520778
75	Tubular atrophy (HP:0000092)	2.00811646
76	Congenital malformation of the right heart (HP:0011723)	1.98317249
77	Double outlet right ventricle (HP:0001719)	1.98317249
78	Chronic bronchitis (HP:0004469)	1.97983051
79	Type I diabetes mellitus (HP:0100651)	1.96741987
80	Pendular nystagmus (HP:0012043)	1.96232933
81	Sandal gap (HP:0001852)	1.94577316
82	Rhinitis (HP:0012384)	1.89874051
83	Unilateral renal agenesis (HP:0000122)	1.87687986
84	Generalized aminoaciduria (HP:0002909)	1.87646132
85	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.83718080
86	Absent epiphyses (HP:0010577)	1.83718080
87	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82920960
88	Abnormality of the parietal bone (HP:0002696)	1.81761845
89	Recurrent pneumonia (HP:0006532)	1.79052474
90	Occipital encephalocele (HP:0002085)	1.76468992
91	Hyponatremia (HP:0002902)	1.75588979
92	Type II lissencephaly (HP:0007260)	1.75573162
93	Obsessive-compulsive behavior (HP:0000722)	1.75181681
94	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.75162712
95	Hyperuricemia (HP:0002149)	1.74728126
96	Increased purine levels (HP:0004368)	1.74728126
97	Abnormality of dental color (HP:0011073)	1.74120547
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73807603
99	Bronchiectasis (HP:0002110)	1.72362038
100	Small intestinal stenosis (HP:0012848)	1.66630871

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.60573561
2	PNCK	4.81098998
3	BRD4	4.40340455
4	PLK2	3.60800941
5	INSRR	2.79347322
6	DDR2	2.66487041
7	TESK1	2.58269659
8	CAMK1G	2.48415975
9	KSR2	2.12606530
10	MUSK	2.10593943
11	STK38	1.95615207
12	MAP3K11	1.88661476
13	MAP3K1	1.75173784
14	BLK	1.72624917
15	MST1R	1.67167785
16	PRKD3	1.63842330
17	OXSR1	1.62516357
18	PIK3CG	1.61589614
19	MAP3K2	1.58497928
20	CDK12	1.57928841
21	TRPM7	1.49111516
22	FRK	1.39167044
23	STK38L	1.38101292
24	MAPK15	1.26492041
25	PDPK1	1.24060817
26	PDK1	1.22499751
27	BMPR1B	1.16718001
28	CAMK1D	1.10058933
29	PTK2B	1.08462422
30	CDK19	1.06097377
31	ACVR1B	1.05063057
32	CDK7	1.04423503
33	MAP4K2	1.01507279
34	MAP3K9	0.99533169
35	PRKAA2	0.92250123
36	JAK3	0.92171734
37	CDC7	0.90163147
38	STK39	0.80823971
39	NEK2	0.80661050
40	ZAK	0.80241532
41	MAP3K12	0.79985621
42	SIK2	0.78461260
43	TLK1	0.77656020
44	MAP2K2	0.76823747
45	TRIM28	0.69363761
46	WNK1	0.69209112
47	RIPK4	0.68502907
48	ADRBK2	0.66827373
49	MARK1	0.65905148
50	DYRK1B	0.65553967
51	TESK2	0.63708395
52	AKT3	0.62394442
53	BRAF	0.61635083
54	CDK1	0.58768392
55	CASK	0.54978200
56	WNK4	0.54363272
57	MAP2K7	0.52432938
58	MAP2K4	0.52178692
59	NEK6	0.49185498
60	CDK2	0.48598342
61	LATS1	0.48341301
62	MAP4K1	0.46527073
63	IRAK2	0.45944189
64	PRKG1	0.45911918
65	CDK4	0.44872509
66	MAP2K1	0.44734219
67	GSK3B	0.43936605
68	SYK	0.43668251
69	EEF2K	0.42812688
70	PAK3	0.42213620
71	MAP3K8	0.41483104
72	GRK6	0.40867248
73	JAK2	0.40637238
74	CSF1R	0.40208678
75	WNK3	0.39160551
76	MAPK8	0.39139635
77	CDK3	0.38097995
78	PRKAA1	0.37631259
79	MAP3K4	0.36928025
80	KIT	0.36302870
81	PLK1	0.36251079
82	PRKCG	0.36050572
83	SGK1	0.36044729
84	PRKG2	0.35845509
85	BRSK2	0.35235327
86	HIPK2	0.34608799
87	CHEK1	0.34562769
88	SRPK1	0.33571443
89	BMPR2	0.32178624
90	DYRK2	0.30529905
91	MAPK1	0.29961252
92	MAPK13	0.28554927
93	PRKCZ	0.27760890
94	STK11	0.27536975
95	TYRO3	0.27243551
96	BUB1	0.27058123
97	RPS6KA2	0.26243454
98	WEE1	0.25291940
99	CHEK2	0.25002064
100	RPS6KA6	0.24629745

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.78712197
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.86670281
3	Olfactory transduction_Homo sapiens_hsa04740	3.25091003
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.04775383
5	Caffeine metabolism_Homo sapiens_hsa00232	2.22556284
6	Adipocytokine signaling pathway_Homo sapiens_hsa04920	2.12749108
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.06599874
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01374531
9	Selenocompound metabolism_Homo sapiens_hsa00450	1.96459210
10	Type II diabetes mellitus_Homo sapiens_hsa04930	1.80597483
11	Nicotine addiction_Homo sapiens_hsa05033	1.78873808
12	Butanoate metabolism_Homo sapiens_hsa00650	1.72151722
13	Taste transduction_Homo sapiens_hsa04742	1.68668641
14	RNA transport_Homo sapiens_hsa03013	1.65349990
15	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.64655634
16	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.64336223
17	Morphine addiction_Homo sapiens_hsa05032	1.61690079
18	Oocyte meiosis_Homo sapiens_hsa04114	1.52180923
19	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.45815332
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.44150540
21	Basal transcription factors_Homo sapiens_hsa03022	1.37278597
22	Fatty acid degradation_Homo sapiens_hsa00071	1.27255226
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.27087072
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.24160324
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.24104990
26	Circadian entrainment_Homo sapiens_hsa04713	1.22840367
27	ABC transporters_Homo sapiens_hsa02010	1.18620561
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17410701
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.13893134
30	Salivary secretion_Homo sapiens_hsa04970	1.11106242
31	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.10955187
32	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.04656138
33	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00145041
34	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.97762703
35	Calcium signaling pathway_Homo sapiens_hsa04020	0.96821285
36	GABAergic synapse_Homo sapiens_hsa04727	0.94130761
37	Phototransduction_Homo sapiens_hsa04744	0.92872041
38	Alcoholism_Homo sapiens_hsa05034	0.92741799
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.91854702
40	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.91377773
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.87394028
42	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.86705531
43	cAMP signaling pathway_Homo sapiens_hsa04024	0.84023547
44	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.82861213
45	Estrogen signaling pathway_Homo sapiens_hsa04915	0.82715458
46	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.81834863
47	Insulin secretion_Homo sapiens_hsa04911	0.80505041
48	MAPK signaling pathway_Homo sapiens_hsa04010	0.79764133
49	Non-small cell lung cancer_Homo sapiens_hsa05223	0.79483793
50	Type I diabetes mellitus_Homo sapiens_hsa04940	0.75566834
51	Bile secretion_Homo sapiens_hsa04976	0.73572963
52	Antigen processing and presentation_Homo sapiens_hsa04612	0.71325783
53	Regulation of autophagy_Homo sapiens_hsa04140	0.70596761
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70374711
55	Cholinergic synapse_Homo sapiens_hsa04725	0.69896961
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.69716000
57	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.66426258
58	Gastric acid secretion_Homo sapiens_hsa04971	0.66150497
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.63838426
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.63576985
61	ErbB signaling pathway_Homo sapiens_hsa04012	0.62665162
62	Lysine degradation_Homo sapiens_hsa00310	0.62431245
63	Homologous recombination_Homo sapiens_hsa03440	0.61113304
64	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.60371188
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58067092
66	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.57010489
67	Gap junction_Homo sapiens_hsa04540	0.55109476
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53617659
69	Renin secretion_Homo sapiens_hsa04924	0.53411940
70	Influenza A_Homo sapiens_hsa05164	0.53160758
71	Viral carcinogenesis_Homo sapiens_hsa05203	0.51854114
72	Pancreatic secretion_Homo sapiens_hsa04972	0.50691752
73	Renin-angiotensin system_Homo sapiens_hsa04614	0.50615021
74	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.48196204
75	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47586159
76	PPAR signaling pathway_Homo sapiens_hsa03320	0.47201011
77	Cell cycle_Homo sapiens_hsa04110	0.46165913
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43046252
79	mTOR signaling pathway_Homo sapiens_hsa04150	0.42944644
80	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.42687921
81	Purine metabolism_Homo sapiens_hsa00230	0.42207737
82	Platelet activation_Homo sapiens_hsa04611	0.42002495
83	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.41843675
84	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.39278961
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.39063272
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38969602
87	Long-term potentiation_Homo sapiens_hsa04720	0.38914462
88	Protein digestion and absorption_Homo sapiens_hsa04974	0.38482443
89	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.37980554
90	Insulin resistance_Homo sapiens_hsa04931	0.37830702
91	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.35753175
92	Prostate cancer_Homo sapiens_hsa05215	0.35701257
93	Renal cell carcinoma_Homo sapiens_hsa05211	0.35171728
94	Serotonergic synapse_Homo sapiens_hsa04726	0.35155981
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.35074843
96	Viral myocarditis_Homo sapiens_hsa05416	0.33585707
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32896255
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.31552724
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.27983140
100	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.27980887

GOLGA8UP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »