ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	6.55956175
2	synapsis (GO:0007129)	6.53696001
3	male meiosis I (GO:0007141)	5.89198997
4	regulation of meiosis I (GO:0060631)	5.37304208
5	DNA methylation involved in gamete generation (GO:0043046)	5.33070687
6	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	5.23275075
7	meiotic chromosome segregation (GO:0045132)	5.13703496
8	male meiosis (GO:0007140)	5.02027767
9	chromosome organization involved in meiosis (GO:0070192)	4.95756828
10	meiosis I (GO:0007127)	4.60316460
11	attachment of spindle microtubules to kinetochore (GO:0008608)	4.36971221
12	meiotic nuclear division (GO:0007126)	4.21186416
13	DNA deamination (GO:0045006)	4.09203373
14	interkinetic nuclear migration (GO:0022027)	4.03210393
15	regulation of DNA endoreduplication (GO:0032875)	4.00629362
16	synaptonemal complex organization (GO:0070193)	3.92651568
17	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.86709719
18	ether lipid metabolic process (GO:0046485)	3.86506637
19	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.83555323
20	axoneme assembly (GO:0035082)	3.83435053
21	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.83108716
22	sister chromatid cohesion (GO:0007062)	3.81962997
23	synaptonemal complex assembly (GO:0007130)	3.77616084
24	phosphatidylglycerol biosynthetic process (GO:0006655)	3.64410326
25	glycerol ether metabolic process (GO:0006662)	3.60391398
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.58117524
27	ether metabolic process (GO:0018904)	3.57903829
28	protein import into peroxisome matrix (GO:0016558)	3.56168290
29	carnitine transmembrane transport (GO:1902603)	3.55102560
30	carnitine transport (GO:0015879)	3.42632077
31	amino-acid betaine transport (GO:0015838)	3.42632077
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.37959633
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.37959633
34	NADH dehydrogenase complex assembly (GO:0010257)	3.37959633
35	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.36911071
36	monoubiquitinated protein deubiquitination (GO:0035520)	3.36569013
37	positive regulation of meiosis (GO:0045836)	3.36496201
38	positive regulation of response to oxidative stress (GO:1902884)	3.36281268
39	positive regulation of cellular response to oxidative stress (GO:1900409)	3.36281268
40	regulation of oxidative stress-induced neuron death (GO:1903203)	3.19797117
41	respiratory chain complex IV assembly (GO:0008535)	3.19154082
42	acrosome reaction (GO:0007340)	3.14750428
43	positive regulation of histone H3-K4 methylation (GO:0051571)	3.13159405
44	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.12289837
45	positive regulation of B cell differentiation (GO:0045579)	3.11916033
46	sperm motility (GO:0030317)	3.10945489
47	meiotic cell cycle process (GO:1903046)	3.09211663
48	positive regulation of meiotic cell cycle (GO:0051446)	3.08251653
49	microtubule depolymerization (GO:0007019)	3.05843336
50	protein complex biogenesis (GO:0070271)	3.05758496
51	centriole replication (GO:0007099)	3.02943931
52	preassembly of GPI anchor in ER membrane (GO:0016254)	3.02230436
53	spermatid development (GO:0007286)	3.00469865
54	DNA synthesis involved in DNA repair (GO:0000731)	2.99409467
55	detection of light stimulus involved in sensory perception (GO:0050962)	2.97036199
56	detection of light stimulus involved in visual perception (GO:0050908)	2.97036199
57	negative regulation of telomerase activity (GO:0051974)	2.95936354
58	photoreceptor cell maintenance (GO:0045494)	2.93239254
59	female gamete generation (GO:0007292)	2.92812042
60	DNA-dependent DNA replication (GO:0006261)	2.92049187
61	mitochondrial genome maintenance (GO:0000002)	2.91835178
62	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	2.91187372
63	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.91102065
64	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	2.90778287
65	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.88460968
66	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.88460968
67	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.88460968
68	nephron tubule morphogenesis (GO:0072078)	2.87651513
69	nephron epithelium morphogenesis (GO:0072088)	2.87651513
70	negative regulation of B cell proliferation (GO:0030889)	2.86641393
71	autophagic vacuole fusion (GO:0000046)	2.85261626
72	Golgi to endosome transport (GO:0006895)	2.81286781
73	translesion synthesis (GO:0019985)	2.80456583
74	nucleobase biosynthetic process (GO:0046112)	2.79489318
75	purine nucleotide salvage (GO:0032261)	2.77270742
76	cytochrome complex assembly (GO:0017004)	2.73472396
77	resolution of meiotic recombination intermediates (GO:0000712)	2.73301735
78	reciprocal DNA recombination (GO:0035825)	2.73125727
79	reciprocal meiotic recombination (GO:0007131)	2.73125727
80	ncRNA 3-end processing (GO:0043628)	2.72884183
81	positive regulation of histone methylation (GO:0031062)	2.72734923
82	fertilization (GO:0009566)	2.70509733
83	cytidine deamination (GO:0009972)	2.69773390
84	cytidine metabolic process (GO:0046087)	2.69773390
85	cytidine catabolic process (GO:0006216)	2.69773390
86	retinal cone cell development (GO:0046549)	2.68669908
87	pericardium development (GO:0060039)	2.65397799
88	pyrimidine nucleotide catabolic process (GO:0006244)	2.64628603
89	C21-steroid hormone biosynthetic process (GO:0006700)	2.63076613
90	DNA biosynthetic process (GO:0071897)	2.62414744
91	GMP metabolic process (GO:0046037)	2.61868716
92	regulation of histone H3-K9 methylation (GO:0051570)	2.61806121
93	rhodopsin mediated signaling pathway (GO:0016056)	2.60888509
94	mannosylation (GO:0097502)	2.59042350
95	C-terminal protein lipidation (GO:0006501)	2.56665208
96	protein localization to peroxisome (GO:0072662)	2.54675097
97	protein targeting to peroxisome (GO:0006625)	2.54675097
98	establishment of protein localization to peroxisome (GO:0072663)	2.54675097
99	response to pheromone (GO:0019236)	2.54623518
100	protein-cofactor linkage (GO:0018065)	2.54606347

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.91860123
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.96802122
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.41409041
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.38575401
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.87456588
6	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.80689005
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.51961681
8	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.22703372
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.20902724
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11497354
11	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.08879472
12	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.04015647
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.87599103
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83133010
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69202068
16	CBP_20019798_ChIP-Seq_JUKART_Human	1.69202068
17	FUS_26573619_Chip-Seq_HEK293_Human	1.67480724
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.66140292
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66001309
20	VDR_22108803_ChIP-Seq_LS180_Human	1.64404176
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62390142
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.61917941
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.57435346
24	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.55816008
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53521471
26	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.53461249
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.51810463
28	EWS_26573619_Chip-Seq_HEK293_Human	1.45421046
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.42791235
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41742419
31	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.38587017
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37793625
33	P300_19829295_ChIP-Seq_ESCs_Human	1.37417124
34	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36933253
35	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.36064339
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.34651138
37	AR_20517297_ChIP-Seq_VCAP_Human	1.34108515
38	GATA3_26560356_Chip-Seq_TH2_Human	1.33598031
39	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.31947127
40	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.30636297
41	SCL_19346495_ChIP-Seq_HPC-7_Human	1.28181693
42	GATA3_26560356_Chip-Seq_TH1_Human	1.26175201
43	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.25711628
44	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25258254
45	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.23728486
46	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.20101536
47	TCF4_23295773_ChIP-Seq_U87_Human	1.19327829
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19130298
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18600140
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.18519856
51	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17710834
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16435677
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14670008
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14670008
55	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14339698
56	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.14282792
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.13996489
58	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12804807
59	STAT3_23295773_ChIP-Seq_U87_Human	1.12465877
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12378644
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12378644
62	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12025247
63	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.11556830
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11160960
65	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.10956166
66	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10805895
67	AR_25329375_ChIP-Seq_VCAP_Human	1.10495165
68	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09633757
69	EZH2_22144423_ChIP-Seq_EOC_Human	1.09282009
70	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.09084478
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08537887
72	NCOR_22424771_ChIP-Seq_293T_Human	1.08406577
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07599987
74	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.07524432
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07499469
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07487973
77	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07487973
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07432511
79	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05865095
80	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.04823973
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04274375
82	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.03765880
83	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02800774
84	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02532229
85	TAF15_26573619_Chip-Seq_HEK293_Human	1.02230231
86	P300_27268052_Chip-Seq_Bcells_Human	1.01439682
87	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01156454
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.00996705
89	RUNX_20019798_ChIP-Seq_JUKART_Human	1.00674347
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.99811313
91	E2F7_22180533_ChIP-Seq_HELA_Human	0.99279573
92	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.98693448
93	PHF8_20622853_ChIP-Seq_HELA_Human	0.98679925
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97796983
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96958013
96	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.96580093
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.96183842
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96122050
99	GBX2_23144817_ChIP-Seq_PC3_Human	0.94939392
100	ERA_21632823_ChIP-Seq_H3396_Human	0.94697044

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.71332761
2	MP0008057_abnormal_DNA_replication	3.53399279
3	MP0000015_abnormal_ear_pigmentation	2.97240810
4	MP0005451_abnormal_body_composition	2.94402193
5	MP0005646_abnormal_pituitary_gland	2.89938151
6	MP0006072_abnormal_retinal_apoptosis	2.75178496
7	MP0008007_abnormal_cellular_replicative	2.74872908
8	MP0005174_abnormal_tail_pigmentation	2.54043211
9	MP0008058_abnormal_DNA_repair	2.35825003
10	MP0005410_abnormal_fertilization	2.27568109
11	MP0001929_abnormal_gametogenesis	2.15300085
12	MP0009046_muscle_twitch	2.13361710
13	MP0003698_abnormal_male_reproductive	2.01463397
14	MP0001661_extended_life_span	2.01348894
15	MP0002210_abnormal_sex_determination	1.97830094
16	MP0004147_increased_porphyrin_level	1.95544950
17	MP0004808_abnormal_hematopoietic_stem	1.95444546
18	MP0000383_abnormal_hair_follicle	1.94746576
19	MP0002138_abnormal_hepatobiliary_system	1.90088844
20	MP0001984_abnormal_olfaction	1.87830286
21	MP0009697_abnormal_copulation	1.86926132
22	MP0003646_muscle_fatigue	1.81799838
23	MP0005671_abnormal_response_to	1.78447772
24	MP0002876_abnormal_thyroid_physiology	1.68082709
25	MP0000569_abnormal_digit_pigmentation	1.64342286
26	MP0006292_abnormal_olfactory_placode	1.63199891
27	MP0005379_endocrine/exocrine_gland_phen	1.62665703
28	MP0003786_premature_aging	1.61492718
29	MP0002160_abnormal_reproductive_system	1.57726743
30	MP0002095_abnormal_skin_pigmentation	1.57226505
31	MP0001145_abnormal_male_reproductive	1.53840277
32	MP0004142_abnormal_muscle_tone	1.52326351
33	MP0003315_abnormal_perineum_morphology	1.51745001
34	MP0000427_abnormal_hair_cycle	1.51698263
35	MP0009278_abnormal_bone_marrow	1.50287623
36	MP0001188_hyperpigmentation	1.47625460
37	MP0000653_abnormal_sex_gland	1.47334301
38	MP0002396_abnormal_hematopoietic_system	1.41945074
39	MP0003787_abnormal_imprinting	1.41924167
40	MP0002163_abnormal_gland_morphology	1.41725662
41	MP0010094_abnormal_chromosome_stability	1.41375044
42	MP0005551_abnormal_eye_electrophysiolog	1.40770547
43	MP0005075_abnormal_melanosome_morpholog	1.40351509
44	MP0010678_abnormal_skin_adnexa	1.39586466
45	MP0001764_abnormal_homeostasis	1.36752850
46	MP0001800_abnormal_humoral_immune	1.34126467
47	MP0005389_reproductive_system_phenotype	1.32768436
48	MP0009764_decreased_sensitivity_to	1.31802833
49	MP0003172_abnormal_lysosome_physiology	1.25538021
50	MP0000371_diluted_coat_color	1.24883982
51	MP0000647_abnormal_sebaceous_gland	1.22818071
52	MP0000685_abnormal_immune_system	1.21490348
53	MP0001529_abnormal_vocalization	1.20758916
54	MP0005253_abnormal_eye_physiology	1.13735984
55	MP0000631_abnormal_neuroendocrine_gland	1.09154738
56	MP0000538_abnormal_urinary_bladder	1.08199201
57	MP0002075_abnormal_coat/hair_pigmentati	1.06560212
58	MP0001835_abnormal_antigen_presentation	1.05586246
59	MP0002877_abnormal_melanocyte_morpholog	1.00479340
60	MP0003011_delayed_dark_adaptation	0.97550635
61	MP0000013_abnormal_adipose_tissue	0.97053398
62	MP0002398_abnormal_bone_marrow	0.94098670
63	MP0006036_abnormal_mitochondrial_physio	0.93785095
64	MP0003121_genomic_imprinting	0.90078497
65	MP0005084_abnormal_gallbladder_morpholo	0.89926321
66	MP0002723_abnormal_immune_serum	0.89050288
67	MP0002733_abnormal_thermal_nociception	0.87729427
68	MP0002161_abnormal_fertility/fecundity	0.87032136
69	MP0001186_pigmentation_phenotype	0.85516349
70	MP0003303_peritoneal_inflammation	0.85064278
71	MP0010386_abnormal_urinary_bladder	0.84250044
72	MP0008004_abnormal_stomach_pH	0.82981219
73	MP0006035_abnormal_mitochondrial_morpho	0.81781790
74	MP0005000_abnormal_immune_tolerance	0.81494650
75	MP0001944_abnormal_pancreas_morphology	0.79982165
76	MP0000230_abnormal_systemic_arterial	0.78806196
77	MP0009745_abnormal_behavioral_response	0.78561832
78	MP0000681_abnormal_thyroid_gland	0.78467908
79	MP0005332_abnormal_amino_acid	0.77197098
80	MP0001270_distended_abdomen	0.75495258
81	MP0001119_abnormal_female_reproductive	0.75061470
82	MP0005397_hematopoietic_system_phenotyp	0.74917214
83	MP0001545_abnormal_hematopoietic_system	0.74917214
84	MP0004043_abnormal_pH_regulation	0.74832563
85	MP0002452_abnormal_antigen_presenting	0.74578726
86	MP0002420_abnormal_adaptive_immunity	0.74447561
87	MP0009250_abnormal_appendicular_skeleto	0.74207338
88	MP0003943_abnormal_hepatobiliary_system	0.74071347
89	MP0001905_abnormal_dopamine_level	0.73803016
90	MP0001819_abnormal_immune_cell	0.72736161
91	MP0000703_abnormal_thymus_morphology	0.72345475
92	MP0000716_abnormal_immune_system	0.72338580
93	MP0003123_paternal_imprinting	0.71823295
94	MP0001501_abnormal_sleep_pattern	0.71301572
95	MP0003195_calcinosis	0.69588956
96	MP0005220_abnormal_exocrine_pancreas	0.69266590
97	MP0008995_early_reproductive_senescence	0.69201217
98	MP0001968_abnormal_touch/_nociception	0.68927569
99	MP0000678_abnormal_parathyroid_gland	0.68332062
100	MP0003186_abnormal_redox_activity	0.68293019

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agammaglobulinemia (HP:0004432)	4.13008241
2	Type I transferrin isoform profile (HP:0003642)	4.09987079
3	Type II lissencephaly (HP:0007260)	4.05148742
4	Delayed CNS myelination (HP:0002188)	3.54111052
5	Metaphyseal dysplasia (HP:0100255)	3.40480574
6	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.34890752
7	Abnormal protein N-linked glycosylation (HP:0012347)	3.34890752
8	Abnormal protein glycosylation (HP:0012346)	3.34890752
9	Abnormal glycosylation (HP:0012345)	3.34890752
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.15949562
11	Neoplasm of the adrenal cortex (HP:0100641)	3.15739362
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.14084156
13	Chronic sinusitis (HP:0011109)	3.07043277
14	Retinal atrophy (HP:0001105)	3.03101583
15	Fair hair (HP:0002286)	2.94777770
16	Nephronophthisis (HP:0000090)	2.92270796
17	Panhypogammaglobulinemia (HP:0003139)	2.83262105
18	Tubulointerstitial nephritis (HP:0001970)	2.82806040
19	Stomach cancer (HP:0012126)	2.78484674
20	Abnormality of the periventricular white matter (HP:0002518)	2.76007128
21	3-Methylglutaconic aciduria (HP:0003535)	2.75725356
22	Abnormality of the renal medulla (HP:0100957)	2.74378613
23	Widely spaced teeth (HP:0000687)	2.71963403
24	Testicular atrophy (HP:0000029)	2.68787836
25	Volvulus (HP:0002580)	2.65789686
26	Reduced antithrombin III activity (HP:0001976)	2.55319097
27	Severe combined immunodeficiency (HP:0004430)	2.52529044
28	Absent speech (HP:0001344)	2.49496588
29	Thyroiditis (HP:0100646)	2.48873881
30	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.45992621
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.45234126
32	Abnormality of chloride homeostasis (HP:0011422)	2.44990667
33	Vacuolated lymphocytes (HP:0001922)	2.43541646
34	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.41529281
35	Intellectual disability, progressive (HP:0006887)	2.37822667
36	Prolonged neonatal jaundice (HP:0006579)	2.37638503
37	Combined immunodeficiency (HP:0005387)	2.32678279
38	Abnormality of the renal cortex (HP:0011035)	2.32555952
39	Abnormality of midbrain morphology (HP:0002418)	2.32027715
40	Molar tooth sign on MRI (HP:0002419)	2.32027715
41	Clumsiness (HP:0002312)	2.30736442
42	Hyperventilation (HP:0002883)	2.30671498
43	Progressive microcephaly (HP:0000253)	2.27388610
44	Acute necrotizing encephalopathy (HP:0006965)	2.23576889
45	Microretrognathia (HP:0000308)	2.23312137
46	Abnormality of B cell number (HP:0010975)	2.23204909
47	Abnormality of eosinophils (HP:0001879)	2.22775449
48	Constricted visual fields (HP:0001133)	2.21543378
49	Autoimmune hemolytic anemia (HP:0001890)	2.21369710
50	Attenuation of retinal blood vessels (HP:0007843)	2.17797118
51	Neonatal respiratory distress (HP:0002643)	2.16711823
52	Hyperkalemia (HP:0002153)	2.14548489
53	Median cleft lip (HP:0000161)	2.12238139
54	Hypoplasia of the uterus (HP:0000013)	2.08696776
55	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.07954695
56	Retinal dysplasia (HP:0007973)	2.07243578
57	Methylmalonic acidemia (HP:0002912)	2.06772533
58	Medial flaring of the eyebrow (HP:0010747)	2.05945941
59	Glucose intolerance (HP:0000833)	2.02947361
60	Oligodactyly (hands) (HP:0001180)	2.01980858
61	Abnormality of fatty-acid metabolism (HP:0004359)	2.00926096
62	Megaloblastic anemia (HP:0001889)	2.00343549
63	Progressive macrocephaly (HP:0004481)	1.97753848
64	Abnormality of the fovea (HP:0000493)	1.95850830
65	Pancreatic fibrosis (HP:0100732)	1.95521431
66	Generalized hypopigmentation of hair (HP:0011358)	1.95050033
67	Severe global developmental delay (HP:0011344)	1.93687025
68	Thickened helices (HP:0000391)	1.93579680
69	Abnormal mitochondria in muscle tissue (HP:0008316)	1.89293645
70	Absent/shortened dynein arms (HP:0200106)	1.86547345
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.86547345
72	Abnormality of T cell physiology (HP:0011840)	1.85491391
73	Abnormality of chromosome segregation (HP:0002916)	1.85415989
74	Hyperglycinemia (HP:0002154)	1.85243408
75	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.85041787
76	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.85041787
77	Increased CSF lactate (HP:0002490)	1.83863053
78	Eosinophilia (HP:0001880)	1.83491276
79	Pancreatic cysts (HP:0001737)	1.83035060
80	Abnormality of dental color (HP:0011073)	1.82816385
81	Intellectual disability, profound (HP:0002187)	1.82316314
82	Chronic hepatic failure (HP:0100626)	1.82063281
83	Cystic liver disease (HP:0006706)	1.80253117
84	Hepatic necrosis (HP:0002605)	1.79866864
85	Mitochondrial inheritance (HP:0001427)	1.79587462
86	Stomatitis (HP:0010280)	1.78262006
87	Cerebellar dysplasia (HP:0007033)	1.77137699
88	Neoplasm of the adrenal gland (HP:0100631)	1.75644560
89	Hypoplasia of the fovea (HP:0007750)	1.74308537
90	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.74308537
91	Albinism (HP:0001022)	1.74154587
92	B lymphocytopenia (HP:0010976)	1.72687117
93	Acute encephalopathy (HP:0006846)	1.72039921
94	Abnormal biliary tract physiology (HP:0012439)	1.70352433
95	Bile duct proliferation (HP:0001408)	1.70352433
96	Aplasia/hypoplasia of the uterus (HP:0008684)	1.66377105
97	Increased serum lactate (HP:0002151)	1.65514901
98	Granulocytopenia (HP:0001913)	1.65069808
99	Congenital, generalized hypertrichosis (HP:0004540)	1.64238641
100	Congenital hepatic fibrosis (HP:0002612)	1.63773420

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPKAPK3	5.38864716
2	EEF2K	4.72708506
3	PNCK	3.74745948
4	CDK19	3.45368985
5	ZAK	3.35179555
6	TRPM7	3.09204164
7	MAPK13	2.67163171
8	PLK2	2.57177693
9	DYRK3	2.46842619
10	FRK	2.42022821
11	TAOK1	2.36161966
12	BMPR1B	2.15282654
13	TAOK3	1.96145705
14	CDK3	1.91660612
15	PLK4	1.82098090
16	PINK1	1.72826751
17	MAPKAPK5	1.70411264
18	CAMK1G	1.55261955
19	CSNK1G3	1.36896326
20	PTK2B	1.26953399
21	MAP3K4	1.25739208
22	MAP4K1	1.21695122
23	CDK6	1.20538305
24	MAPK11	1.19963482
25	ACVR1B	1.19081485
26	CSF1R	1.18180847
27	CSNK1G1	1.15477709
28	MAP3K13	1.11896845
29	MET	1.10814070
30	IRAK1	1.06746628
31	FGR	1.06216657
32	RPS6KB2	1.02516474
33	NTRK3	0.99037237
34	CSNK1A1L	0.97671383
35	KIT	0.97314488
36	CHEK2	0.96503778
37	TTK	0.93473796
38	JAK3	0.93140166
39	CSNK1G2	0.90895049
40	TEC	0.90171135
41	RIPK4	0.88125248
42	RPS6KA4	0.86841791
43	SYK	0.86804811
44	MAPK12	0.85841805
45	ADRBK2	0.84276449
46	AKT3	0.83136609
47	GRK7	0.82407555
48	IRAK2	0.82030267
49	CDK4	0.76380705
50	MAP2K7	0.75227390
51	ITK	0.72694421
52	SGK1	0.68613072
53	INSRR	0.68047782
54	KSR2	0.66997944
55	ATR	0.65025818
56	BUB1	0.64959923
57	MAP3K2	0.64658564
58	BMPR2	0.64230447
59	GRK1	0.63855894
60	PRKCI	0.60827429
61	RPS6KA2	0.58777568
62	WNK4	0.56937766
63	TAOK2	0.56000585
64	CCNB1	0.55565675
65	CDK9	0.54512744
66	MAP3K7	0.53996627
67	TLK1	0.53772889
68	SIK2	0.53656306
69	UHMK1	0.52080912
70	ATM	0.48655072
71	RPS6KA5	0.46085546
72	TNK2	0.45288479
73	PRKG1	0.45240577
74	BTK	0.40999784
75	HIPK2	0.39584224
76	MAP3K5	0.39492903
77	MST4	0.38103295
78	EIF2AK2	0.38082574
79	PDK1	0.36831635
80	IKBKE	0.36368683
81	MAP3K6	0.35786433
82	TBK1	0.35368266
83	BRAF	0.34449362
84	SGK2	0.34377338
85	RPS6KB1	0.33536645
86	PRKCE	0.31761210
87	MELK	0.31513371
88	TGFBR1	0.31422847
89	CSNK1D	0.30925432
90	EIF2AK1	0.30853050
91	HCK	0.29888057
92	YES1	0.29504087
93	DAPK2	0.29188547
94	BMX	0.28801921
95	PRKCQ	0.28138391
96	NEK2	0.28006243
97	MAP2K1	0.26329235
98	CSNK1E	0.26156393
99	ERBB3	0.25571313
100	NME2	0.25556240

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.45497662
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.14658512
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.10292254
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.98073258
5	Base excision repair_Homo sapiens_hsa03410	2.72634821
6	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.65785923
7	Phototransduction_Homo sapiens_hsa04744	2.56223395
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.35215401
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.31626223
10	Allograft rejection_Homo sapiens_hsa05330	2.19263411
11	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.18927193
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.12021678
13	Sulfur metabolism_Homo sapiens_hsa00920	2.03580097
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.78281804
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.73486548
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72940361
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.66959655
18	Regulation of autophagy_Homo sapiens_hsa04140	1.49558484
19	Olfactory transduction_Homo sapiens_hsa04740	1.44503262
20	DNA replication_Homo sapiens_hsa03030	1.43322491
21	Homologous recombination_Homo sapiens_hsa03440	1.42335126
22	RNA transport_Homo sapiens_hsa03013	1.36083223
23	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.29104951
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.26223178
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.26018309
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.21315746
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.20742274
28	Basal transcription factors_Homo sapiens_hsa03022	1.20058675
29	RNA polymerase_Homo sapiens_hsa03020	1.18989244
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.13916138
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13794222
32	Fatty acid elongation_Homo sapiens_hsa00062	1.12104898
33	RNA degradation_Homo sapiens_hsa03018	1.04679666
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.00894181
35	Peroxisome_Homo sapiens_hsa04146	0.99313346
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97749366
37	Mismatch repair_Homo sapiens_hsa03430	0.97330603
38	Purine metabolism_Homo sapiens_hsa00230	0.94529456
39	Oxidative phosphorylation_Homo sapiens_hsa00190	0.94298519
40	Fatty acid metabolism_Homo sapiens_hsa01212	0.90732674
41	Butanoate metabolism_Homo sapiens_hsa00650	0.86398169
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86063018
43	Morphine addiction_Homo sapiens_hsa05032	0.85427809
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84418001
45	Protein export_Homo sapiens_hsa03060	0.83805773
46	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.81290708
47	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.80364643
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74664271
49	Viral myocarditis_Homo sapiens_hsa05416	0.73739767
50	mTOR signaling pathway_Homo sapiens_hsa04150	0.72838392
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.69671176
52	Circadian entrainment_Homo sapiens_hsa04713	0.68320877
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.66508440
54	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.66129850
55	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.65821836
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65742751
57	Herpes simplex infection_Homo sapiens_hsa05168	0.64496454
58	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.63344754
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62889145
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62117001
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62066816
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61816612
63	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58445547
64	Insulin secretion_Homo sapiens_hsa04911	0.57929302
65	Small cell lung cancer_Homo sapiens_hsa05222	0.56965754
66	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.53516670
67	Dopaminergic synapse_Homo sapiens_hsa04728	0.53120344
68	Leishmaniasis_Homo sapiens_hsa05140	0.52789485
69	Propanoate metabolism_Homo sapiens_hsa00640	0.51679035
70	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.50719507
71	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.49081858
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48860401
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48254829
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.47840331
75	Spliceosome_Homo sapiens_hsa03040	0.47367649
76	Toxoplasmosis_Homo sapiens_hsa05145	0.47355541
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.46973847
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.46751921
79	Fatty acid degradation_Homo sapiens_hsa00071	0.46733108
80	Other glycan degradation_Homo sapiens_hsa00511	0.46555943
81	p53 signaling pathway_Homo sapiens_hsa04115	0.46441910
82	Serotonergic synapse_Homo sapiens_hsa04726	0.45621754
83	Renin secretion_Homo sapiens_hsa04924	0.45135918
84	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.42707084
85	Salivary secretion_Homo sapiens_hsa04970	0.42000938
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.41191781
87	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.41150415
88	Lysine degradation_Homo sapiens_hsa00310	0.38739603
89	Linoleic acid metabolism_Homo sapiens_hsa00591	0.36556983
90	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36352795
91	Parkinsons disease_Homo sapiens_hsa05012	0.35693747
92	Nicotine addiction_Homo sapiens_hsa05033	0.35567276
93	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.35481571
94	One carbon pool by folate_Homo sapiens_hsa00670	0.35403012
95	Nitrogen metabolism_Homo sapiens_hsa00910	0.34896094
96	Tryptophan metabolism_Homo sapiens_hsa00380	0.32947693
97	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32717006
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31828030
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.31558875
100	Oocyte meiosis_Homo sapiens_hsa04114	0.31124753

GOLGA8VP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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