GOLGB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.38772065
2Golgi transport vesicle coating (GO:0048200)5.38772065
3protein targeting to Golgi (GO:0000042)4.29167179
4establishment of protein localization to Golgi (GO:0072600)4.05442147
5COPII vesicle coating (GO:0048208)3.93690076
6retrograde transport, vesicle recycling within Golgi (GO:0000301)3.92353492
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.85178447
8macroautophagy (GO:0016236)3.80740552
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.65092483
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.57951283
11insulin-like growth factor receptor signaling pathway (GO:0048009)3.45369715
12exocrine pancreas development (GO:0031017)3.38477732
13histone H3-K4 trimethylation (GO:0080182)3.37090371
14positive regulation of nuclease activity (GO:0032075)3.35737383
15vesicle coating (GO:0006901)3.28390879
16regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.27191286
17protein localization to Golgi apparatus (GO:0034067)3.13177696
18fibroblast migration (GO:0010761)3.11205729
19monoubiquitinated protein deubiquitination (GO:0035520)3.09217458
20desmosome organization (GO:0002934)3.08307675
21interkinetic nuclear migration (GO:0022027)3.06422552
22intra-Golgi vesicle-mediated transport (GO:0006891)3.06076195
23peptide hormone processing (GO:0016486)3.04816763
24endoplasmic reticulum unfolded protein response (GO:0030968)3.03733939
25pericardium development (GO:0060039)3.00240228
26auditory receptor cell differentiation (GO:0042491)2.98842835
27regulation of nuclease activity (GO:0032069)2.97889076
28ER-nucleus signaling pathway (GO:0006984)2.97371012
29ER overload response (GO:0006983)2.97185480
30protein retention in ER lumen (GO:0006621)2.96365420
31cellular response to unfolded protein (GO:0034620)2.93799730
32protein targeting to lysosome (GO:0006622)2.93790177
33establishment of protein localization to vacuole (GO:0072666)2.93790177
34protein targeting to vacuole (GO:0006623)2.93790177
35regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.92498795
36bundle of His cell to Purkinje myocyte communication (GO:0086069)2.89790156
37endocrine pancreas development (GO:0031018)2.88375856
38insulin secretion (GO:0030073)2.84393999
39cytoplasmic mRNA processing body assembly (GO:0033962)2.83198900
40early endosome to late endosome transport (GO:0045022)2.80282712
41inner ear receptor cell development (GO:0060119)2.70409198
42cellular response to topologically incorrect protein (GO:0035967)2.70213879
43sequestering of extracellular ligand from receptor (GO:0035581)2.68923420
44iron ion import (GO:0097286)2.68488668
45regulation of establishment or maintenance of cell polarity (GO:0032878)2.68386377
46type B pancreatic cell development (GO:0003323)2.65037584
47regulation of establishment of cell polarity (GO:2000114)2.64950584
48peptidyl-lysine trimethylation (GO:0018023)2.64101355
49Golgi to endosome transport (GO:0006895)2.63669347
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61385627
51regulation of pigment cell differentiation (GO:0050932)2.61381128
52positive regulation of glycolytic process (GO:0045821)2.57914979
53positive regulation of glycogen biosynthetic process (GO:0045725)2.57265843
54phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.57146208
55negative regulation of keratinocyte proliferation (GO:0010839)2.55681856
56response to endoplasmic reticulum stress (GO:0034976)2.54090890
57detection of calcium ion (GO:0005513)2.53547250
58ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.52691513
59stress granule assembly (GO:0034063)2.52457098
60regulation of RNA export from nucleus (GO:0046831)2.50178543
61positive regulation of histone deacetylation (GO:0031065)2.49449515
62endocrine hormone secretion (GO:0060986)2.48123152
63prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.46222767
64embryonic retina morphogenesis in camera-type eye (GO:0060059)2.44889967
65smooth muscle tissue development (GO:0048745)2.41294826
66nucleus localization (GO:0051647)2.40946948
67relaxation of cardiac muscle (GO:0055119)2.40364440
68phospholipid translocation (GO:0045332)2.40015308
69regulation of ARF protein signal transduction (GO:0032012)2.39658871
70glandular epithelial cell development (GO:0002068)2.39207630
71histone H3-K9 demethylation (GO:0033169)2.38938493
72positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.37476807
73hemidesmosome assembly (GO:0031581)2.37457393
74regulation of type B pancreatic cell apoptotic process (GO:2000674)2.37380217
75cytoskeletal anchoring at plasma membrane (GO:0007016)2.37178259
76peptidyl-lysine methylation (GO:0018022)2.35322733
77cellular response to ethanol (GO:0071361)2.34364858
78embryonic foregut morphogenesis (GO:0048617)2.34226461
79sequestering of metal ion (GO:0051238)2.34071649
80endoplasmic reticulum organization (GO:0007029)2.33579821
81growth hormone receptor signaling pathway (GO:0060396)2.33246882
82regulation of protein polyubiquitination (GO:1902914)2.32172833
83Golgi to plasma membrane transport (GO:0006893)2.30896355
84regulation of transforming growth factor beta2 production (GO:0032909)2.30886267
85branching involved in prostate gland morphogenesis (GO:0060442)2.30250667
86regulation of axon extension involved in axon guidance (GO:0048841)2.30003481
87genitalia morphogenesis (GO:0035112)2.29063154
88columnar/cuboidal epithelial cell development (GO:0002066)2.28706562
89positive regulation of p38MAPK cascade (GO:1900745)2.28478807
90response to unfolded protein (GO:0006986)2.28195167
91artery development (GO:0060840)2.27885142
92positive regulation of glycogen metabolic process (GO:0070875)2.27092457
93negative regulation of hormone biosynthetic process (GO:0032353)2.26769692
94activation of protein kinase A activity (GO:0034199)2.26767030
95* Golgi organization (GO:0007030)2.26675982
96glandular epithelial cell differentiation (GO:0002067)2.26358425
97regulation of insulin secretion (GO:0050796)2.26126295
98positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.25024565
99coronary vasculature morphogenesis (GO:0060977)2.25000072
100mitotic sister chromatid cohesion (GO:0007064)2.24965653
101cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.24601729
1024-hydroxyproline metabolic process (GO:0019471)2.24379688
103regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.24088472
104protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.23641066
105negative regulation of systemic arterial blood pressure (GO:0003085)2.23469855
106apical protein localization (GO:0045176)2.23194192
107ear development (GO:0043583)2.23169389
108cellular response to vitamin D (GO:0071305)2.22551531
109positive regulation of fatty acid beta-oxidation (GO:0032000)2.22481342
110negative regulation of complement activation (GO:0045916)2.22452240
111Sertoli cell development (GO:0060009)2.22006762
112interleukin-6-mediated signaling pathway (GO:0070102)2.21350812
113neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.20714378
114toxin transport (GO:1901998)2.20665409
115intestinal cholesterol absorption (GO:0030299)2.20002884
116peptide secretion (GO:0002790)2.19937335
117apoptotic cell clearance (GO:0043277)2.19777325
118regulation of clathrin-mediated endocytosis (GO:2000369)2.19703784
119embryonic camera-type eye morphogenesis (GO:0048596)2.19428484
120cellular response to vitamin (GO:0071295)2.18312087
121positive regulation of insulin secretion (GO:0032024)2.18160054
122protein K48-linked deubiquitination (GO:0071108)2.17866782
123carnitine transmembrane transport (GO:1902603)2.17841008
124regulation of protein glycosylation (GO:0060049)2.17268295
125amino-acid betaine transport (GO:0015838)2.16431524
126carnitine transport (GO:0015879)2.16431524
127face morphogenesis (GO:0060325)2.16407230
128Golgi to plasma membrane protein transport (GO:0043001)2.15957494
129negative regulation of protein activation cascade (GO:2000258)2.15748444
130regulation of glucose import in response to insulin stimulus (GO:2001273)2.15166202
131mannose metabolic process (GO:0006013)2.14913798
132cilium movement (GO:0003341)2.14780979
133response to topologically incorrect protein (GO:0035966)2.13843271
134establishment of nucleus localization (GO:0040023)2.13725188
135protein maturation by protein folding (GO:0022417)2.13304822
136chemosensory behavior (GO:0007635)2.13213972
137carnitine shuttle (GO:0006853)2.12563549
138positive regulation of vesicle fusion (GO:0031340)2.12260434
139toxin metabolic process (GO:0009404)2.11962587
140regulation of nucleobase-containing compound transport (GO:0032239)2.11749668
141peptide hormone secretion (GO:0030072)2.10879346
142plasma membrane repair (GO:0001778)2.10549850
143inositol phosphate-mediated signaling (GO:0048016)2.10382464
144L-alpha-amino acid transmembrane transport (GO:1902475)2.10182112
145negative regulation of fatty acid transport (GO:2000192)2.10095189
146negative regulation of glycogen biosynthetic process (GO:0045719)2.09954591
147cilium or flagellum-dependent cell motility (GO:0001539)2.08219724
148semaphorin-plexin signaling pathway (GO:0071526)2.07443546
149negative regulation of axon extension involved in axon guidance (GO:0048843)2.06895148
150regulation of polysaccharide biosynthetic process (GO:0032885)2.06835663
151transcytosis (GO:0045056)2.06533270
152membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.06499260
153positive regulation of hormone biosynthetic process (GO:0046886)2.05969779
154cellular response to growth hormone stimulus (GO:0071378)2.05793532
155regulation of glycogen biosynthetic process (GO:0005979)2.05781199
156regulation of glucan biosynthetic process (GO:0010962)2.05781199
157collagen fibril organization (GO:0030199)2.05643618
158intestinal epithelial cell development (GO:0060576)2.04582223
159regulation of keratinocyte proliferation (GO:0010837)2.04577086
160regulation of peptide hormone secretion (GO:0090276)2.04018932
161regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.03870233
162phospholipid homeostasis (GO:0055091)2.03029953
163hormone catabolic process (GO:0042447)2.02441712
164cerebellar Purkinje cell layer development (GO:0021680)2.02426938
165UDP-N-acetylglucosamine metabolic process (GO:0006047)2.02366705
166negative regulation of glycogen metabolic process (GO:0070874)2.01553188
167endocardial cushion development (GO:0003197)2.01410442
168regulation of peptide secretion (GO:0002791)2.01330706
169import into cell (GO:0098657)2.01268797
170negative regulation of neurotransmitter secretion (GO:0046929)2.01011406
171nerve growth factor signaling pathway (GO:0038180)2.00145464
172acrosome assembly (GO:0001675)1.99878699
173regulation of cholesterol homeostasis (GO:2000188)1.99071957
174regulation of short-term neuronal synaptic plasticity (GO:0048172)1.99008389
175Leydig cell differentiation (GO:0033327)1.98876902
176regulation of fatty acid beta-oxidation (GO:0031998)1.98391535
177negative regulation of hormone metabolic process (GO:0032351)1.98359834
178negative regulation of translation, ncRNA-mediated (GO:0040033)1.98267525
179regulation of translation, ncRNA-mediated (GO:0045974)1.98267525
180negative regulation of translation involved in gene silencing by miRNA (GO:0035278)1.98267525
181chondrocyte development (GO:0002063)1.97500453
182vesicle transport along microtubule (GO:0047496)1.97104224
183lipid translocation (GO:0034204)1.95498921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09711653
2ZNF217_24962896_ChIP-Seq_MCF-7_Human2.15106008
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.12410202
4CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96618574
5GATA1_22025678_ChIP-Seq_K562_Human1.95158606
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.89351694
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88842463
8LXR_22158963_ChIP-Seq_LIVER_Mouse1.82740949
9DROSHA_22980978_ChIP-Seq_HELA_Human1.73966451
10GBX2_23144817_ChIP-Seq_PC3_Human1.71742375
11RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69026553
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68053527
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66615369
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66142703
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.62977990
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61213276
17AHR_22903824_ChIP-Seq_MCF-7_Human1.58413652
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.54648844
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54350248
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.51097963
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50872206
22EZH2_22144423_ChIP-Seq_EOC_Human1.49411614
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.49322609
24AR_21572438_ChIP-Seq_LNCaP_Human1.47724011
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.46423111
26BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44142367
27* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42633168
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41909695
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41531840
30SMAD4_21799915_ChIP-Seq_A2780_Human1.40959868
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40722619
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37304937
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37304937
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.35243612
35TAF15_26573619_Chip-Seq_HEK293_Human1.33905953
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.33593920
37STAT3_23295773_ChIP-Seq_U87_Human1.33215293
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.32183175
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30463176
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30454764
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29912959
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29328806
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27555704
44CLOCK_20551151_ChIP-Seq_293T_Human1.27292774
45BCAT_22108803_ChIP-Seq_LS180_Human1.27141606
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27125846
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26114750
48ER_23166858_ChIP-Seq_MCF-7_Human1.25964776
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25375276
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23865271
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.23361440
52TP53_16413492_ChIP-PET_HCT116_Human1.23354158
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.22647142
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22437304
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22037610
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21779534
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18693956
58P300_19829295_ChIP-Seq_ESCs_Human1.18642273
59SMAD3_21741376_ChIP-Seq_HESCs_Human1.18023132
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.17660373
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17013738
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16234361
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16218733
64STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16072732
65PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15936643
66BRD4_25478319_ChIP-Seq_HGPS_Human1.14925985
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14027157
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13717563
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13347294
70AR_19668381_ChIP-Seq_PC3_Human1.13284111
71ZNF274_21170338_ChIP-Seq_K562_Hela1.13177491
72CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12985282
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12588907
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12180218
75CDX2_22108803_ChIP-Seq_LS180_Human1.12106177
76FUS_26573619_Chip-Seq_HEK293_Human1.12019280
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.10877970
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10203934
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09478219
80* TP53_18474530_ChIP-ChIP_U2OS_Human1.07995746
81* TCF4_23295773_ChIP-Seq_U87_Human1.07986995
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07397013
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06553696
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06371088
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.05772788
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.05683691
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05318848
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04295651
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04004952
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03933951
91PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02883130
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02621387
93RXR_22108803_ChIP-Seq_LS180_Human1.02000100
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.01995216
95TCF4_22108803_ChIP-Seq_LS180_Human1.01827498
96* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01548572
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01366070
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.01256973
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.01256973
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00328026
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00161947
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00028517
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99960970
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99722458
105TP63_17297297_ChIP-ChIP_HaCaT_Human0.99720124
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99256001
107SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98732897
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98600344
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98600344
110FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98483310
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98203529
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98203529
113RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98128958
114EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98128958
115CJUN_26792858_Chip-Seq_BT549_Human0.97584727
116VDR_22108803_ChIP-Seq_LS180_Human0.96816346
117CBP_20019798_ChIP-Seq_JUKART_Human0.96092351
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96092351
119FOXA1_25552417_ChIP-Seq_VCAP_Human0.95964397
120RUNX2_22187159_ChIP-Seq_PCA_Human0.95897221
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.95875298
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.95500060
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94017266
124KDM2B_26808549_Chip-Seq_K562_Human0.93827442
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93100130
126* TP63_23658742_ChIP-Seq_EP156T_Human0.92900579
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92269991
128AR_25329375_ChIP-Seq_VCAP_Human0.91408486
129TCF4_18268006_ChIP-ChIP_LS174T_Human0.91175862
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.90227296
131FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90065768
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88285925
133SOX2_20726797_ChIP-Seq_SW620_Human0.86586523
134RNF2_27304074_Chip-Seq_ESCs_Mouse0.86223931
135* REST_21632747_ChIP-Seq_MESCs_Mouse0.85587229
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.85446321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.56461311
2MP0000569_abnormal_digit_pigmentation3.43755669
3MP0003283_abnormal_digestive_organ3.20684178
4MP0002909_abnormal_adrenal_gland3.16729385
5MP0002877_abnormal_melanocyte_morpholog2.99083673
6MP0002837_dystrophic_cardiac_calcinosis2.95428027
7MP0000013_abnormal_adipose_tissue2.80673545
8MP0010234_abnormal_vibrissa_follicle2.78631633
9MP0004043_abnormal_pH_regulation2.61900885
10MP0003252_abnormal_bile_duct2.46698437
11MP0003183_abnormal_peptide_metabolism2.33651755
12MP0003045_fibrosis2.32699553
13MP0002693_abnormal_pancreas_physiology2.31461300
14MP0001944_abnormal_pancreas_morphology2.30486081
15MP0005409_darkened_coat_color2.23307331
16MP0003195_calcinosis2.20171980
17MP0005365_abnormal_bile_salt2.17380236
18MP0003300_gastrointestinal_ulcer2.16976847
19MP0003890_abnormal_embryonic-extraembry2.10872864
20MP0000383_abnormal_hair_follicle2.10786087
21MP0010386_abnormal_urinary_bladder2.09534899
22MP0004264_abnormal_extraembryonic_tissu2.09149113
23MP0000003_abnormal_adipose_tissue2.06921231
24MP0010678_abnormal_skin_adnexa1.90663842
25MP0008057_abnormal_DNA_replication1.88251961
26MP0002139_abnormal_hepatobiliary_system1.78114659
27MP0008438_abnormal_cutaneous_collagen1.75235960
28MP0002896_abnormal_bone_mineralization1.73260948
29MP0005220_abnormal_exocrine_pancreas1.72094724
30MP0002078_abnormal_glucose_homeostasis1.71041941
31MP0005379_endocrine/exocrine_gland_phen1.67958455
32MP0005670_abnormal_white_adipose1.65127348
33MP0003705_abnormal_hypodermis_morpholog1.62499167
34MP0008961_abnormal_basal_metabolism1.59071489
35MP0005375_adipose_tissue_phenotype1.51679839
36MP0001299_abnormal_eye_distance/1.49004596
37MP0003950_abnormal_plasma_membrane1.45385634
38MP0010368_abnormal_lymphatic_system1.43675216
39MP0003868_abnormal_feces_composition1.40079289
40MP0001502_abnormal_circadian_rhythm1.39551082
41MP0001666_abnormal_nutrient_absorption1.38538290
42MP0002168_other_aberrant_phenotype1.35847855
43MP0001879_abnormal_lymphatic_vessel1.34557107
44MP0005076_abnormal_cell_differentiation1.33539028
45MP0001765_abnormal_ion_homeostasis1.33473263
46MP0004130_abnormal_muscle_cell1.32997325
47MP0005085_abnormal_gallbladder_physiolo1.29517898
48MP0005275_abnormal_skin_tensile1.29471286
49MP0002928_abnormal_bile_duct1.28899165
50MP0000427_abnormal_hair_cycle1.24598360
51MP0003122_maternal_imprinting1.23363071
52MP0005187_abnormal_penis_morphology1.23292180
53MP0005666_abnormal_adipose_tissue1.23288507
54MP0004270_analgesia1.21563563
55MP0010329_abnormal_lipoprotein_level1.19485581
56MP0004185_abnormal_adipocyte_glucose1.18793719
57MP0003172_abnormal_lysosome_physiology1.18501526
58MP0004272_abnormal_basement_membrane1.16562541
59MP0000678_abnormal_parathyroid_gland1.15779528
60MP0001958_emphysema1.15573979
61MP0002876_abnormal_thyroid_physiology1.14777218
62MP0002234_abnormal_pharynx_morphology1.13075597
63MP0005248_abnormal_Harderian_gland1.12035841
64MP0003787_abnormal_imprinting1.10746004
65MP0000767_abnormal_smooth_muscle1.10021916
66MP0005535_abnormal_body_temperature1.08023600
67MP0003937_abnormal_limbs/digits/tail_de1.07990210
68MP0000462_abnormal_digestive_system1.07580686
69MP0003121_genomic_imprinting1.04493166
70MP0005058_abnormal_lysosome_morphology1.04136211
71MP0000534_abnormal_ureter_morphology1.03979340
72MP0005257_abnormal_intraocular_pressure1.03333024
73MP0003953_abnormal_hormone_level1.01654417
74MP0002109_abnormal_limb_morphology1.00917139
75MP0002118_abnormal_lipid_homeostasis1.00834871
76MP0003942_abnormal_urinary_system1.00488305
77MP0005448_abnormal_energy_balance1.00082874
78MP0005310_abnormal_salivary_gland0.99493206
79MP0000432_abnormal_head_morphology0.99182527
80MP0005408_hypopigmentation0.99141751
81MP0001661_extended_life_span0.96575206
82MP0005334_abnormal_fat_pad0.96404854
83MP0003935_abnormal_craniofacial_develop0.95628851
84MP0000428_abnormal_craniofacial_morphol0.94633532
85MP0004134_abnormal_chest_morphology0.94596774
86MP0005023_abnormal_wound_healing0.94241462
87MP0002115_abnormal_skeleton_extremities0.93464861
88MP0004084_abnormal_cardiac_muscle0.91766973
89MP0008877_abnormal_DNA_methylation0.91429558
90MP0003755_abnormal_palate_morphology0.91313684
91MP0004859_abnormal_synaptic_plasticity0.91211193
92MP0003936_abnormal_reproductive_system0.91029886
93MP0006072_abnormal_retinal_apoptosis0.90677413
94MP0000778_abnormal_nervous_system0.89997638
95MP0001756_abnormal_urination0.89995728
96MP0005645_abnormal_hypothalamus_physiol0.89360802
97MP0003115_abnormal_respiratory_system0.88604298
98MP0005360_urolithiasis0.88162354
99MP0002009_preneoplasia0.88101288
100MP0000371_diluted_coat_color0.87580067
101MP0005646_abnormal_pituitary_gland0.87356176
102MP0002108_abnormal_muscle_morphology0.85346941
103MP0002295_abnormal_pulmonary_circulatio0.85175019
104MP0000627_abnormal_mammary_gland0.84994191
105MP0006138_congestive_heart_failure0.84741057
106MP0000538_abnormal_urinary_bladder0.83381756
107MP0008875_abnormal_xenobiotic_pharmacok0.82745402
108MP0002925_abnormal_cardiovascular_devel0.82563125
109MP0003941_abnormal_skin_development0.82265385
110MP0002971_abnormal_brown_adipose0.81617891
111MP0003385_abnormal_body_wall0.81523427
112MP0003566_abnormal_cell_adhesion0.80949171
113MP0009643_abnormal_urine_homeostasis0.79495408
114MP0009384_cardiac_valve_regurgitation0.79431826
115MP0001177_atelectasis0.77639816
116MP0003279_aneurysm0.75349406
117MP0004085_abnormal_heartbeat0.74775166
118MP0005503_abnormal_tendon_morphology0.74697821
119MP0009115_abnormal_fat_cell0.74163872
120MP0000377_abnormal_hair_follicle0.73316295
121MP0002116_abnormal_craniofacial_bone0.72846004
122MP0004145_abnormal_muscle_electrophysio0.72814652
123MP0002233_abnormal_nose_morphology0.72725652
124MP0000613_abnormal_salivary_gland0.72202893
125MP0003959_abnormal_lean_body0.71711332
126MP0005367_renal/urinary_system_phenotyp0.70950346
127MP0000516_abnormal_urinary_system0.70950346
128MP0009703_decreased_birth_body0.70768639
129MP0002166_altered_tumor_susceptibility0.70481401
130MP0002138_abnormal_hepatobiliary_system0.70017876
131MP0002060_abnormal_skin_morphology0.69162529
132MP0004036_abnormal_muscle_relaxation0.69085837
133MP0000266_abnormal_heart_morphology0.69061035
134MP0001270_distended_abdomen0.68951179
135MP0000639_abnormal_adrenal_gland0.68350089
136MP0003091_abnormal_cell_migration0.68011186
137MP0002084_abnormal_developmental_patter0.67753373
138MP0002098_abnormal_vibrissa_morphology0.67426290
139MP0005508_abnormal_skeleton_morphology0.66679909
140MP0000609_abnormal_liver_physiology0.66487608
141MP0002090_abnormal_vision0.65647836
142MP0005164_abnormal_response_to0.65198627
143MP0002128_abnormal_blood_circulation0.65127738
144MP0010352_gastrointestinal_tract_polyps0.65061763
145MP0006054_spinal_hemorrhage0.64097755
146MP0000230_abnormal_systemic_arterial0.63500731
147MP0003633_abnormal_nervous_system0.63323449
148MP0005623_abnormal_meninges_morphology0.62713483
149MP0004233_abnormal_muscle_weight0.62427232
150MP0000751_myopathy0.62315617
151MP0002269_muscular_atrophy0.59938703

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.88461510
2Hypoglycemic seizures (HP:0002173)4.47832666
3Hypoglycemic coma (HP:0001325)4.02497561
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.96672993
5Symptomatic seizures (HP:0011145)3.87407306
6Hyperglycemia (HP:0003074)3.75351099
7Insulin-resistant diabetes mellitus (HP:0000831)3.53342267
8Macroorchidism (HP:0000053)3.28813244
9Ketoacidosis (HP:0001993)3.08650948
10Overgrowth (HP:0001548)3.05750505
11Absent frontal sinuses (HP:0002688)2.91002836
12Vertebral arch anomaly (HP:0008438)2.77770249
13Hypoplastic ischia (HP:0003175)2.73821255
14Abnormality of the ischium (HP:0003174)2.73055975
15Abnormality of the intrinsic pathway (HP:0010989)2.64302519
16Aneurysm (HP:0002617)2.60348936
17Abnormality of endocrine pancreas physiology (HP:0012093)2.57850742
18Abnormality of the pancreatic islet cells (HP:0006476)2.57850742
19Cerebral aneurysm (HP:0004944)2.55367086
20Tubulointerstitial nephritis (HP:0001970)2.50892274
21Decreased circulating renin level (HP:0003351)2.50757594
22Conjugated hyperbilirubinemia (HP:0002908)2.47453405
23Aortic dissection (HP:0002647)2.46871966
24Pancreatic islet-cell hyperplasia (HP:0004510)2.44130714
25Retinal atrophy (HP:0001105)2.39907080
26Abnormality of the nasal septum (HP:0000419)2.37174776
27Abnormality of calcium-phosphate metabolism (HP:0100530)2.30903649
28Agitation (HP:0000713)2.30704649
29Skin nodule (HP:0200036)2.30392535
30Curly hair (HP:0002212)2.28806246
31Urinary glycosaminoglycan excretion (HP:0003541)2.27407290
32Mucopolysacchariduria (HP:0008155)2.27407290
33Hyperventilation (HP:0002883)2.26929881
34Protuberant abdomen (HP:0001538)2.24187712
35Abnormality of the common coagulation pathway (HP:0010990)2.22296607
36Hyperkalemia (HP:0002153)2.21011332
37Abnormality of polysaccharide metabolism (HP:0011012)2.16858749
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16858749
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16858749
40Turricephaly (HP:0000262)2.15977687
41Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.13797725
42Ketosis (HP:0001946)2.13609014
43Flat acetabular roof (HP:0003180)2.12338996
44Abdominal distention (HP:0003270)2.12254389
45Right ventricular cardiomyopathy (HP:0011663)2.07443863
46EEG with generalized epileptiform discharges (HP:0011198)2.05093267
47Abnormality of incisor morphology (HP:0011063)2.03823284
48Hypsarrhythmia (HP:0002521)2.03563383
49Limited hip movement (HP:0008800)2.00378351
50Abnormality of the renal cortex (HP:0011035)1.98038754
51Long toe (HP:0010511)1.97877637
52Lip pit (HP:0100267)1.97565230
53Hypokalemia (HP:0002900)1.97229065
54Abnormality of the epiphyses of the hand (HP:0005924)1.97072617
55Epileptiform EEG discharges (HP:0011182)1.97068391
56Laryngomalacia (HP:0001601)1.96544085
57Hypoplastic labia majora (HP:0000059)1.95328231
58Late onset (HP:0003584)1.95204126
59Abnormal pancreas size (HP:0012094)1.94671054
60Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93787589
61Mildly elevated creatine phosphokinase (HP:0008180)1.93465445
62Atrophic scars (HP:0001075)1.93351701
63Thyroid carcinoma (HP:0002890)1.91573390
64Abnormality of potassium homeostasis (HP:0011042)1.90832570
65Bronchomalacia (HP:0002780)1.90638226
66Abnormality of the renal medulla (HP:0100957)1.89536926
67Large for gestational age (HP:0001520)1.88823121
68Papillary thyroid carcinoma (HP:0002895)1.88606261
69Acute myeloid leukemia (HP:0004808)1.88604227
70Blue irides (HP:0000635)1.88384582
71Heterotopia (HP:0002282)1.87892781
72Protruding tongue (HP:0010808)1.86952393
73Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.86361675
74Genetic anticipation (HP:0003743)1.86119744
75Dysostosis multiplex (HP:0000943)1.85761358
76Aortic aneurysm (HP:0004942)1.84995445
77Neonatal short-limb short stature (HP:0008921)1.83120198
78Congenital glaucoma (HP:0001087)1.82634206
79Intrahepatic cholestasis (HP:0001406)1.79973539
80Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79688746
81Resting tremor (HP:0002322)1.79360335
82Chronic hepatic failure (HP:0100626)1.79116275
83Pulmonic stenosis (HP:0001642)1.78392546
84Menstrual irregularities (HP:0000858)1.77608018
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76857134
86Generalized hypopigmentation of hair (HP:0011358)1.76743224
87Obstructive sleep apnea (HP:0002870)1.76001946
88Decreased lacrimation (HP:0000633)1.75538203
89Sparse lateral eyebrow (HP:0005338)1.75221014
90Oligomenorrhea (HP:0000876)1.74818549
91Shawl scrotum (HP:0000049)1.74052702
92Tubular atrophy (HP:0000092)1.73886925
93Bell-shaped thorax (HP:0001591)1.73794133
94Metaphyseal dysplasia (HP:0100255)1.73164642
95Cystic hygroma (HP:0000476)1.72383826
96Hand muscle atrophy (HP:0009130)1.72296777
97Hyporeflexia of lower limbs (HP:0002600)1.71709046
98Vitreoretinal degeneration (HP:0000655)1.71565220
99Broad palm (HP:0001169)1.71435887
100Arterial tortuosity (HP:0005116)1.70954399
101Deep philtrum (HP:0002002)1.70891367
102Upper limb amyotrophy (HP:0009129)1.70753895
103Distal upper limb amyotrophy (HP:0007149)1.70753895
104Insulin resistance (HP:0000855)1.70117347
105Severe Myopia (HP:0011003)1.70098741
106Abnormality of the labia majora (HP:0012881)1.70013438
107Hip dysplasia (HP:0001385)1.69996668
108Rhinitis (HP:0012384)1.69024289
109Long eyelashes (HP:0000527)1.68081807
110Thick eyebrow (HP:0000574)1.66560336
111Fair hair (HP:0002286)1.66152909
112Abnormality of the fingertips (HP:0001211)1.66084807
113Cerebral inclusion bodies (HP:0100314)1.65327711
114Enlarged penis (HP:0000040)1.63954247
115Short thorax (HP:0010306)1.63318220
116Urethral obstruction (HP:0000796)1.63059741
117Aortic regurgitation (HP:0001659)1.62861132
118Abnormal foot bone ossification (HP:0010675)1.62002298
119Exostoses (HP:0100777)1.60568412
120Hypopigmentation of the fundus (HP:0007894)1.60438363
121Germ cell neoplasia (HP:0100728)1.59537063
122Cystic liver disease (HP:0006706)1.59519715
123Hypoplasia of the iris (HP:0007676)1.59388337
124Global brain atrophy (HP:0002283)1.59091373
125Short middle phalanx of finger (HP:0005819)1.59049342
126Thoracolumbar scoliosis (HP:0002944)1.58713256
127Cervical subluxation (HP:0003308)1.58337425
128Narrow palate (HP:0000189)1.57454526
129Protrusio acetabuli (HP:0003179)1.57207350
130Neoplasm of the heart (HP:0100544)1.56961809
131Prominent forehead (HP:0011220)1.56728899
132Broad metatarsal (HP:0001783)1.56645416
133Tapered finger (HP:0001182)1.55601995
134Buphthalmos (HP:0000557)1.55362148
135Dysmetric saccades (HP:0000641)1.55174951
136Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.54307388
137Widely spaced teeth (HP:0000687)1.53881561
138Severe short stature (HP:0003510)1.53639372
139Wide nose (HP:0000445)1.53568040
140Vascular tortuosity (HP:0004948)1.53475131
141Open mouth (HP:0000194)1.52733368
142Neonatal hypoglycemia (HP:0001998)1.52576274
143Exotropia (HP:0000577)1.52521152
144Chronic bronchitis (HP:0004469)1.52363555
145Limb hypertonia (HP:0002509)1.52275387
146Alacrima (HP:0000522)1.52007782
147Abnormality of the frontal sinuses (HP:0002687)1.51825500
148Short chin (HP:0000331)1.51360852
149Back pain (HP:0003418)1.51181198
150Abnormality of chloride homeostasis (HP:0011422)1.51113102
151Hypoplastic scapulae (HP:0000882)1.50545598
152Aplasia/Hypoplasia of the scapulae (HP:0006713)1.50545598
153Action tremor (HP:0002345)1.50543400
154Tibial bowing (HP:0002982)1.50506054
155Advanced eruption of teeth (HP:0006288)1.50117521
156Enlarged kidneys (HP:0000105)1.50102452
157Mitral valve prolapse (HP:0001634)1.50092285
158Mitral stenosis (HP:0001718)1.50004488
159Truncal obesity (HP:0001956)1.49098792
160Visual hallucinations (HP:0002367)1.48901457
161Hepatoblastoma (HP:0002884)1.47710292
162Infantile muscular hypotonia (HP:0008947)1.47696471
163Abnormality of renin-angiotensin system (HP:0000847)1.47256265
164Pigmentary retinal degeneration (HP:0001146)1.47163100
165Cubitus valgus (HP:0002967)1.47011547
166Thin bony cortex (HP:0002753)1.46976404
167Bundle branch block (HP:0011710)1.46878673
168Shallow orbits (HP:0000586)1.46816692
169Volvulus (HP:0002580)1.46496618

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.43718169
2FRK3.46496358
3TAOK33.35706829
4MAP3K22.98433008
5CAMK1G2.50666818
6LATS12.44213613
7STK38L2.41572772
8SIK12.41416407
9CAMK1D2.28666809
10CASK2.14059001
11PRKD31.97179052
12ERN11.93044842
13AKT31.89334964
14PDGFRA1.89298630
15NTRK31.78025803
16STK391.76152576
17TRPM71.71628565
18RIPK11.61122195
19TRIB31.57183507
20EPHA21.54827531
21CDK121.49270164
22NLK1.43781018
23PTK61.42414606
24ACVR1B1.42178958
25BMPR1B1.36961037
26PTK21.35043189
27HIPK21.34211586
28NTRK11.29187777
29PAK31.28150747
30CDC42BPA1.27570673
31PASK1.27561510
32WNK11.25107841
33BRD41.25084322
34FER1.24602439
35PRKCH1.23524650
36DDR21.18921244
37SCYL21.15807857
38MAP3K41.13096126
39JAK11.12477794
40SGK31.11937408
41MYLK1.10031779
42WNK41.09637999
43PIK3CA1.08885988
44NUAK11.08022331
45FGFR21.07569184
46RET1.05731004
47DMPK1.05424594
48EIF2AK31.03890840
49EPHA31.03656215
50PDGFRB0.98984136
51MTOR0.97639473
52SGK20.96159368
53TTN0.95171011
54MAPK150.94882758
55FGFR30.94789555
56NEK60.92113834
57EEF2K0.91795080
58IRAK30.90894623
59MAP3K10.89624613
60MAP3K30.88424628
61MET0.86604395
62FGFR40.85462482
63MAP3K60.84084955
64CAMKK20.82620530
65PRKD20.82246875
66LMTK20.80483392
67DAPK20.76952998
68PIK3CG0.75458557
69CAMKK10.74500803
70MST40.72069437
71MAP3K90.71636734
72PRKAA10.71346310
73MELK0.70680696
74BCR0.70071467
75MARK20.68997650
76SGK10.67809049
77RIPK40.66998555
78SGK4940.66197995
79SGK2230.66197995
80MST1R0.65895570
81PKN20.65739694
82TNIK0.65620660
83STK240.65615032
84OXSR10.65539385
85TNK20.65021165
86MKNK20.64756067
87MAP2K40.63960417
88STK380.63170145
89JAK20.62683720
90PRKD10.62500654
91PRKAA20.62462292
92BRSK20.61856333
93PNCK0.61373773
94CSNK1E0.59563800
95DYRK1B0.58097762
96EPHB10.57036390
97KSR20.56764706
98WNK30.56705458
99FLT30.56667644
100MAP3K70.56237805
101SIK20.55367252
102PDPK10.52557862
103RPS6KA20.51570963
104PRKCE0.51435944
105ICK0.49886065
106TEC0.44188975
107RPS6KA30.44052187
108MAPK80.43934621
109KSR10.43566648
110IGF1R0.42861087
111CDK50.42346203
112STK30.42319124
113MAPK100.42199733
114GSK3B0.41398545
115MAPK10.41374634
116CAMK2D0.41246871
117MAPK140.40340932
118RPS6KB10.40102587
119STK110.40016230
120EPHA40.39937673
121PAK20.39062926
122MAP3K100.38613208
123FGFR10.37549405
124ERBB20.37113345
125CHUK0.37038643
126CDK30.36858994
127GSK3A0.36805712
128PAK60.36048380
129ROCK10.35675359
130NEK90.35355040
131PDK10.33924193
132CAMK10.33826857
133ATM0.33271835
134PTK2B0.31112034
135TYRO30.30602621

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.17339596
2Type II diabetes mellitus_Homo sapiens_hsa049302.32394716
3Insulin secretion_Homo sapiens_hsa049112.24981987
4Sulfur metabolism_Homo sapiens_hsa009201.90142721
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83946558
6Carbohydrate digestion and absorption_Homo sapiens_hsa049731.45673058
7Nitrogen metabolism_Homo sapiens_hsa009101.43545600
8Fatty acid biosynthesis_Homo sapiens_hsa000611.36179421
9Lysine degradation_Homo sapiens_hsa003101.34738403
10Protein export_Homo sapiens_hsa030601.32356072
11Histidine metabolism_Homo sapiens_hsa003401.31359402
12Insulin resistance_Homo sapiens_hsa049311.30610952
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26603753
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24205674
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22984399
16Thyroid hormone synthesis_Homo sapiens_hsa049181.21931911
17Choline metabolism in cancer_Homo sapiens_hsa052311.18620913
18ABC transporters_Homo sapiens_hsa020101.18098971
19Cocaine addiction_Homo sapiens_hsa050301.16999125
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16408633
21Glucagon signaling pathway_Homo sapiens_hsa049221.16186035
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14242164
23Renin secretion_Homo sapiens_hsa049241.13714030
24Tight junction_Homo sapiens_hsa045301.13117888
25Long-term potentiation_Homo sapiens_hsa047201.12536096
26Amphetamine addiction_Homo sapiens_hsa050311.12041632
27Pancreatic secretion_Homo sapiens_hsa049721.11047761
28Tryptophan metabolism_Homo sapiens_hsa003801.10148901
29TGF-beta signaling pathway_Homo sapiens_hsa043501.06174937
30Vibrio cholerae infection_Homo sapiens_hsa051101.05494354
31FoxO signaling pathway_Homo sapiens_hsa040681.02893744
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01853870
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.01752507
34Notch signaling pathway_Homo sapiens_hsa043301.00659966
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00612820
36Estrogen signaling pathway_Homo sapiens_hsa049150.99661531
37Axon guidance_Homo sapiens_hsa043600.99584596
38Dorso-ventral axis formation_Homo sapiens_hsa043200.99222849
39Sphingolipid metabolism_Homo sapiens_hsa006000.98321284
40Bile secretion_Homo sapiens_hsa049760.96910222
41Circadian entrainment_Homo sapiens_hsa047130.96692229
42Hippo signaling pathway_Homo sapiens_hsa043900.96237958
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94696811
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92315253
45mTOR signaling pathway_Homo sapiens_hsa041500.92089184
46Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90706815
47Salivary secretion_Homo sapiens_hsa049700.89377177
48Cholinergic synapse_Homo sapiens_hsa047250.88877527
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88702505
50Mineral absorption_Homo sapiens_hsa049780.88354705
51Protein digestion and absorption_Homo sapiens_hsa049740.87502403
52Dopaminergic synapse_Homo sapiens_hsa047280.87318609
53Butanoate metabolism_Homo sapiens_hsa006500.87257600
54Taste transduction_Homo sapiens_hsa047420.85443106
55GABAergic synapse_Homo sapiens_hsa047270.84735701
56Insulin signaling pathway_Homo sapiens_hsa049100.84192218
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83527837
58Linoleic acid metabolism_Homo sapiens_hsa005910.83481821
59Gastric acid secretion_Homo sapiens_hsa049710.83475954
60Starch and sucrose metabolism_Homo sapiens_hsa005000.83196207
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.82472166
62Adherens junction_Homo sapiens_hsa045200.82393926
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82300682
64Dilated cardiomyopathy_Homo sapiens_hsa054140.82123379
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81957178
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.81798545
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81388709
68Synaptic vesicle cycle_Homo sapiens_hsa047210.80257159
69Fat digestion and absorption_Homo sapiens_hsa049750.80136393
70MicroRNAs in cancer_Homo sapiens_hsa052060.79782934
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77792838
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77639323
73Thyroid cancer_Homo sapiens_hsa052160.76864574
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76125623
75ECM-receptor interaction_Homo sapiens_hsa045120.75958236
76Glioma_Homo sapiens_hsa052140.75825721
77Focal adhesion_Homo sapiens_hsa045100.75029320
78Long-term depression_Homo sapiens_hsa047300.74190810
79Fatty acid degradation_Homo sapiens_hsa000710.74046777
80Type I diabetes mellitus_Homo sapiens_hsa049400.73538753
81AMPK signaling pathway_Homo sapiens_hsa041520.73247816
82cAMP signaling pathway_Homo sapiens_hsa040240.73191880
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72619936
84Lysosome_Homo sapiens_hsa041420.72415185
85Hedgehog signaling pathway_Homo sapiens_hsa043400.72326620
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72198930
87Renal cell carcinoma_Homo sapiens_hsa052110.71709126
88GnRH signaling pathway_Homo sapiens_hsa049120.71423068
89Small cell lung cancer_Homo sapiens_hsa052220.71326347
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70981366
91Retinol metabolism_Homo sapiens_hsa008300.70967773
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70873269
93Prolactin signaling pathway_Homo sapiens_hsa049170.70864775
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.69477039
95PPAR signaling pathway_Homo sapiens_hsa033200.69077087
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68332882
97Wnt signaling pathway_Homo sapiens_hsa043100.67220363
98Morphine addiction_Homo sapiens_hsa050320.66375647
99Amoebiasis_Homo sapiens_hsa051460.66239818
100Basal cell carcinoma_Homo sapiens_hsa052170.65774195
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65608572
102Glutamatergic synapse_Homo sapiens_hsa047240.65371162
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65091002
104Circadian rhythm_Homo sapiens_hsa047100.64557481
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64543190
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64398785
107Chemical carcinogenesis_Homo sapiens_hsa052040.63334224
108beta-Alanine metabolism_Homo sapiens_hsa004100.62877939
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.62781206
110Prostate cancer_Homo sapiens_hsa052150.62683595
111Inositol phosphate metabolism_Homo sapiens_hsa005620.61858580
112Platelet activation_Homo sapiens_hsa046110.60878413
113Oxytocin signaling pathway_Homo sapiens_hsa049210.60795701
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.60399109
115Fatty acid metabolism_Homo sapiens_hsa012120.59833751
116Melanogenesis_Homo sapiens_hsa049160.59337736
117N-Glycan biosynthesis_Homo sapiens_hsa005100.58974878
118Pathways in cancer_Homo sapiens_hsa052000.58634001
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58206608
120Prion diseases_Homo sapiens_hsa050200.57807899
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57734432
122Arginine biosynthesis_Homo sapiens_hsa002200.57334082
123Olfactory transduction_Homo sapiens_hsa047400.57071844
124Melanoma_Homo sapiens_hsa052180.56828733
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56457218
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.56100204
127Proteoglycans in cancer_Homo sapiens_hsa052050.55980561
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54151075
129Ovarian steroidogenesis_Homo sapiens_hsa049130.53814046
130Endometrial cancer_Homo sapiens_hsa052130.53493847
131Glycerolipid metabolism_Homo sapiens_hsa005610.52900372
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52671558
133Serotonergic synapse_Homo sapiens_hsa047260.51891200
134ErbB signaling pathway_Homo sapiens_hsa040120.49758197
135Propanoate metabolism_Homo sapiens_hsa006400.46974331
136Calcium signaling pathway_Homo sapiens_hsa040200.46890850
137Complement and coagulation cascades_Homo sapiens_hsa046100.46265530

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