GOLIM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)5.16747765
2glomerular basement membrane development (GO:0032836)4.53285667
3glomerular epithelial cell development (GO:0072310)4.49550779
4desmosome organization (GO:0002934)3.99747916
5Golgi transport vesicle coating (GO:0048200)3.79720878
6COPI coating of Golgi vesicle (GO:0048205)3.79720878
7peptidyl-glutamic acid carboxylation (GO:0017187)3.71453749
8protein carboxylation (GO:0018214)3.71453749
9sequestering of extracellular ligand from receptor (GO:0035581)3.58374157
10positive regulation of actin filament depolymerization (GO:0030836)3.55461190
11collagen fibril organization (GO:0030199)3.47027427
12cellular response to vitamin D (GO:0071305)3.42209628
13L-phenylalanine catabolic process (GO:0006559)3.34894009
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.34894009
15negative regulation of fibrinolysis (GO:0051918)3.34617436
16COPII vesicle coating (GO:0048208)3.33887721
17regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.26621342
18hemidesmosome assembly (GO:0031581)3.25172916
19positive regulation of fatty acid beta-oxidation (GO:0032000)3.21677512
20cell adhesion mediated by integrin (GO:0033627)3.20524232
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19952791
22positive regulation of glycoprotein biosynthetic process (GO:0010560)3.18041491
23skin morphogenesis (GO:0043589)3.17599055
24regulation of fibrinolysis (GO:0051917)3.16350103
25atrioventricular valve morphogenesis (GO:0003181)3.14871714
26L-phenylalanine metabolic process (GO:0006558)3.05270594
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.05270594
28fibrinolysis (GO:0042730)3.01781965
29inositol phosphate-mediated signaling (GO:0048016)3.00772305
30exocrine pancreas development (GO:0031017)2.93541764
31vascular endothelial growth factor signaling pathway (GO:0038084)2.91660876
32cell migration involved in sprouting angiogenesis (GO:0002042)2.90749551
33vascular smooth muscle contraction (GO:0014829)2.90233624
34positive regulation of p38MAPK cascade (GO:1900745)2.89572571
35regulation of cardioblast differentiation (GO:0051890)2.88446474
36protein retention in ER lumen (GO:0006621)2.87570010
37chondrocyte proliferation (GO:0035988)2.84158346
38regulation of cardioblast proliferation (GO:0003264)2.84043299
39regulation of secondary heart field cardioblast proliferation (GO:0003266)2.84043299
40G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.83211843
41glomerulus development (GO:0032835)2.82479135
42cellular response to vitamin (GO:0071295)2.81115490
43gland morphogenesis (GO:0022612)2.80285585
44regulation of plasminogen activation (GO:0010755)2.79501153
45glial cell proliferation (GO:0014009)2.77402679
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.77243494
47zinc ion transport (GO:0006829)2.76394677
48chondrocyte development (GO:0002063)2.76275834
49midgut development (GO:0007494)2.73653444
50positive regulation of protein autophosphorylation (GO:0031954)2.73149586
51aromatic amino acid family catabolic process (GO:0009074)2.72926708
52positive regulation of glycolytic process (GO:0045821)2.70842390
53regulation of hexokinase activity (GO:1903299)2.70325326
54regulation of glucokinase activity (GO:0033131)2.70325326
55endocrine pancreas development (GO:0031018)2.69602937
56insulin-like growth factor receptor signaling pathway (GO:0048009)2.69068092
57lung vasculature development (GO:0060426)2.68768535
58positive regulation of glycoprotein metabolic process (GO:1903020)2.66246688
59endodermal cell differentiation (GO:0035987)2.64898436
60protein heterotetramerization (GO:0051290)2.64853468
61keratan sulfate catabolic process (GO:0042340)2.64427008
62cellular glucuronidation (GO:0052695)2.64316006
63embryonic foregut morphogenesis (GO:0048617)2.61055182
64extracellular regulation of signal transduction (GO:1900115)2.59363575
65extracellular negative regulation of signal transduction (GO:1900116)2.59363575
66positive regulation of muscle hypertrophy (GO:0014742)2.59099929
67positive regulation of cardiac muscle hypertrophy (GO:0010613)2.59099929
68organ formation (GO:0048645)2.58914604
69regulation of protein activation cascade (GO:2000257)2.57869992
70peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.57408299
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.57335090
72embryonic retina morphogenesis in camera-type eye (GO:0060059)2.56771358
73bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55537683
74protein heterotrimerization (GO:0070208)2.52579211
75regulation of cholesterol homeostasis (GO:2000188)2.52257442
76sequestering of metal ion (GO:0051238)2.51002522
77negative regulation of lipase activity (GO:0060192)2.50852321
78lymph vessel development (GO:0001945)2.50362859
79protein localization to cell surface (GO:0034394)2.49648352
80positive regulation of fatty acid oxidation (GO:0046321)2.49106444
81mesenchymal cell proliferation (GO:0010463)2.47511346
82negative regulation of fatty acid transport (GO:2000192)2.46274582
83alpha-linolenic acid metabolic process (GO:0036109)2.46200898
84regulation of complement activation (GO:0030449)2.45659969
85parental behavior (GO:0060746)2.45370557
86regulation of endothelial cell chemotaxis (GO:2001026)2.45083241
87sulfur amino acid catabolic process (GO:0000098)2.44515473
88type B pancreatic cell development (GO:0003323)2.44095552
89complement activation, alternative pathway (GO:0006957)2.43283172
90high-density lipoprotein particle remodeling (GO:0034375)2.43246749
91regulation of type B pancreatic cell apoptotic process (GO:2000674)2.43153247
924-hydroxyproline metabolic process (GO:0019471)2.42805583
93epoxygenase P450 pathway (GO:0019373)2.41852362
94basement membrane organization (GO:0071711)2.41519632
95endocardial cushion development (GO:0003197)2.41128789
96bile acid and bile salt transport (GO:0015721)2.39728475
97venous blood vessel morphogenesis (GO:0048845)2.39497503
98lipoprotein metabolic process (GO:0042157)2.39258208
99positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.37955897
100intestinal cholesterol absorption (GO:0030299)2.37806565
101nephron tubule formation (GO:0072079)2.37588547
102positive regulation of endothelial cell apoptotic process (GO:2000353)2.37326866
103auditory receptor cell differentiation (GO:0042491)2.37184224
104astrocyte development (GO:0014002)2.36833794
105positive regulation of cartilage development (GO:0061036)2.36769035
106lactate metabolic process (GO:0006089)2.36013290
107endocardial cushion morphogenesis (GO:0003203)2.35717190
108regulation of protein glycosylation (GO:0060049)2.35198013
109activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35020415
110mesodermal cell differentiation (GO:0048333)2.34541616
111regulation of fatty acid beta-oxidation (GO:0031998)2.33924923
112renal filtration (GO:0097205)2.33864341
113C4-dicarboxylate transport (GO:0015740)2.33526871
114blood vessel endothelial cell migration (GO:0043534)2.32779085
115triglyceride homeostasis (GO:0070328)2.32614529
116acylglycerol homeostasis (GO:0055090)2.32614529
117negative regulation of keratinocyte proliferation (GO:0010839)2.32396399
118apoptotic cell clearance (GO:0043277)2.31662793
119cellular ketone body metabolic process (GO:0046950)2.31546785
120smooth muscle tissue development (GO:0048745)2.31387582
121positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.30798806
122limb bud formation (GO:0060174)2.30648094
123positive regulation of extracellular matrix organization (GO:1903055)2.30314850
124bile acid biosynthetic process (GO:0006699)2.30037973
125endothelial cell morphogenesis (GO:0001886)2.29951137
126UDP-N-acetylglucosamine metabolic process (GO:0006047)2.29780909
127positive regulation of hormone biosynthetic process (GO:0046886)2.29311484
128positive regulation of collagen biosynthetic process (GO:0032967)2.29267221
129uronic acid metabolic process (GO:0006063)2.28927667
130glucuronate metabolic process (GO:0019585)2.28927667
131phospholipid efflux (GO:0033700)2.28410518
132collagen metabolic process (GO:0032963)2.27827552
133negative regulation of hormone biosynthetic process (GO:0032353)2.27745983
134retina vasculature morphogenesis in camera-type eye (GO:0061299)2.27604463
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.26863824
136regulation of phospholipase A2 activity (GO:0032429)2.26685919
137regulation of integrin-mediated signaling pathway (GO:2001044)2.26634213
138positive regulation of osteoblast proliferation (GO:0033690)2.26312573
139heart valve morphogenesis (GO:0003179)2.25726624
140retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.25480969
141wound healing, spreading of epidermal cells (GO:0035313)2.25480804
142positive regulation of steroid metabolic process (GO:0045940)2.24800036
143positive regulation of cell junction assembly (GO:1901890)2.24592393
144positive regulation of focal adhesion assembly (GO:0051894)2.24592393
145multicellular organismal macromolecule metabolic process (GO:0044259)2.24548859
146homocysteine metabolic process (GO:0050667)2.24250548
147negative regulation of hormone metabolic process (GO:0032351)2.23979239
148negative regulation of wound healing (GO:0061045)2.23952072
149ER overload response (GO:0006983)2.22212007
150platelet dense granule organization (GO:0060155)2.19588995
151negative regulation of axon extension involved in axon guidance (GO:0048843)2.19414637
152dermatan sulfate biosynthetic process (GO:0030208)2.17966523
153chondroitin sulfate catabolic process (GO:0030207)2.17316851
154metanephric tubule development (GO:0072170)2.17253466
155metanephric nephron tubule development (GO:0072234)2.17253466
156regulation of sulfur metabolic process (GO:0042762)2.15529600
157ketone body metabolic process (GO:1902224)2.14385495
158renal tubule morphogenesis (GO:0061333)2.14290514
159signal peptide processing (GO:0006465)2.12419575
160negative regulation of chondrocyte differentiation (GO:0032331)2.12295500
161angiotensin maturation (GO:0002003)2.11187313
162negative regulation of cytosolic calcium ion concentration (GO:0051481)2.11087206
163type B pancreatic cell proliferation (GO:0044342)2.10310843
164astrocyte differentiation (GO:0048708)2.10280063
165eosinophil chemotaxis (GO:0048245)2.08847171
166hair cell differentiation (GO:0035315)2.06062054
167mesenchymal-epithelial cell signaling (GO:0060638)2.05705074
168peptide hormone processing (GO:0016486)2.02374828
169regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.01930663
170glomerular filtration (GO:0003094)2.01582221
171detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.01396637
172fucose metabolic process (GO:0006004)1.99956331
173tonic smooth muscle contraction (GO:0014820)1.99802746
174relaxation of cardiac muscle (GO:0055119)1.99431834
175cell migration involved in heart development (GO:0060973)1.98965784
176regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.98837833
177coenzyme catabolic process (GO:0009109)1.96886973
178transcytosis (GO:0045056)1.95687103
179regulation of metalloenzyme activity (GO:0048552)1.95462931
180artery development (GO:0060840)1.95385118
181water-soluble vitamin biosynthetic process (GO:0042364)1.94691123
182reverse cholesterol transport (GO:0043691)1.94562781
183inner ear receptor stereocilium organization (GO:0060122)1.94225122
184prostate gland growth (GO:0060736)1.92778411
185regulation of chondrocyte differentiation (GO:0032330)1.92585857
186nucleotide-sugar biosynthetic process (GO:0009226)1.92111065
187mesenchyme morphogenesis (GO:0072132)1.91557357
188regulation of ER to Golgi vesicle-mediated transport (GO:0060628)1.91327166
189embryonic forelimb morphogenesis (GO:0035115)1.90381294
190auditory receptor cell stereocilium organization (GO:0060088)1.90347257

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.46275699
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.76010895
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.67897453
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.59427986
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.19003728
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18962565
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.10350371
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.81881729
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67879510
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67645324
11CLOCK_20551151_ChIP-Seq_293T_Human2.63485481
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.61971795
13GBX2_23144817_ChIP-Seq_PC3_Human2.44624098
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33957962
15* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.30970955
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28048932
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.27469440
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.09343649
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.05679638
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.05352132
21GATA1_22025678_ChIP-Seq_K562_Human2.02061154
22VDR_22108803_ChIP-Seq_LS180_Human2.01263148
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.01055721
24P300_19829295_ChIP-Seq_ESCs_Human1.94994494
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.93178433
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.92667732
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92559734
28FUS_26573619_Chip-Seq_HEK293_Human1.91346276
29* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90577262
30* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.90014116
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88901529
32CJUN_26792858_Chip-Seq_BT549_Human1.85752232
33TAF15_26573619_Chip-Seq_HEK293_Human1.81829190
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81749941
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81306827
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.75938800
37* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75577513
38* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75505735
39SOX2_20726797_ChIP-Seq_SW620_Human1.75250345
40SMAD4_21799915_ChIP-Seq_A2780_Human1.73465609
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.72836175
42* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.71914806
43* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.71914806
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69809336
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67376733
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65998092
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.64523308
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63448309
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61498061
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59801267
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.58838177
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57733830
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.57292363
54CDX2_22108803_ChIP-Seq_LS180_Human1.56672287
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52454602
56* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50319807
57* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50319807
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.50036604
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48447076
60* EWS_26573619_Chip-Seq_HEK293_Human1.47848044
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47768835
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46754582
63BRD4_25478319_ChIP-Seq_HGPS_Human1.46425186
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46030706
65* FOXO3_23340844_ChIP-Seq_DLD1_Human1.44853902
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44173152
67AR_21909140_ChIP-Seq_LNCAP_Human1.44050256
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43761535
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.43226885
70* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42358928
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41868992
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41805663
73* NANOG_18555785_Chip-Seq_ESCs_Mouse1.40811923
74IGF1R_20145208_ChIP-Seq_DFB_Human1.39403115
75* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38434789
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.38299238
77AR_25329375_ChIP-Seq_VCAP_Human1.38255912
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36744990
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36180481
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33471936
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32637050
82* TP53_18474530_ChIP-ChIP_U2OS_Human1.31965310
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30863452
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30454755
85* STAT3_23295773_ChIP-Seq_U87_Human1.29599371
86* P53_22387025_ChIP-Seq_ESCs_Mouse1.29413762
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28482562
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28147065
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.27914506
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27472381
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26320965
92TP53_16413492_ChIP-PET_HCT116_Human1.26172704
93* GATA4_25053715_ChIP-Seq_YYC3_Human1.25577973
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.25304786
95MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.25267355
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24659722
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24273284
98* TCF4_22108803_ChIP-Seq_LS180_Human1.24149384
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23493830
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23222054
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22793432
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.20434936
103TBX20_22080862_ChIP-Seq_HEART_Mouse1.20434936
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20357178
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.19794078
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.19264070
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.18780119
108NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16739319
109* SOX2_19829295_ChIP-Seq_ESCs_Human1.15785652
110* NANOG_19829295_ChIP-Seq_ESCs_Human1.15785652
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15214328
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14942834
113CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13478071
114OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13325279
115TCF4_18268006_ChIP-ChIP_LS174T_Human1.12687437
116TCF4_23295773_ChIP-Seq_U87_Human1.12297702
117EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11713730
118ZNF274_21170338_ChIP-Seq_K562_Hela1.11295557
119ELK1_19687146_ChIP-ChIP_HELA_Human1.11062587
120SOX2_18555785_Chip-Seq_ESCs_Mouse1.09599678
121* TP63_23658742_ChIP-Seq_EP156T_Human1.07579810
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06547874
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06501495
124HTT_18923047_ChIP-ChIP_STHdh_Human1.06393253
125CBP_20019798_ChIP-Seq_JUKART_Human1.06306670
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06306670
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06195375
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06120832
129STAT3_18555785_Chip-Seq_ESCs_Mouse1.06083082
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05905291
131JUN_21703547_ChIP-Seq_K562_Human1.05726010
132P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05683674
133P300_18555785_Chip-Seq_ESCs_Mouse1.05044624
134UBF1/2_26484160_Chip-Seq_HMECs_Human1.04608497
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03735322
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03585145
137RXR_22108803_ChIP-Seq_LS180_Human1.03372883
138CDX2_20551321_ChIP-Seq_CACO-2_Human1.03363654
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03019248
140TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02767304
141KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02503594
142ER_23166858_ChIP-Seq_MCF-7_Human1.01824494
143WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01820320
144FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01686006
145ISL1_27105846_Chip-Seq_CPCs_Mouse1.01365560
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01123801
147JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00426190
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00087183
149* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99990685
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99285084
151ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96994843
152HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96712463
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96518077
154BCAT_22108803_ChIP-Seq_LS180_Human0.96344957
155AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96135936
156KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96097215
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95408425
158SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95298189
159GATA3_24758297_ChIP-Seq_MCF-7_Human0.94911993
160FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93474485
161AHR_22903824_ChIP-Seq_MCF-7_Human0.93375274
162* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92929529
163* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91714041
164GATA6_25053715_ChIP-Seq_YYC3_Human0.89997480
165EED_16625203_ChIP-ChIP_MESCs_Mouse0.85473442
166P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83835680
167Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82914294
168FOXA1_25552417_ChIP-Seq_VCAP_Human0.82548977
169FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82352861
170TP53_20018659_ChIP-ChIP_R1E_Mouse0.80102975
171TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79916419
172HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78514442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.78228676
2MP0005275_abnormal_skin_tensile3.67723747
3MP0005503_abnormal_tendon_morphology3.43482920
4MP0002139_abnormal_hepatobiliary_system2.98097870
5MP0003705_abnormal_hypodermis_morpholog2.80874075
6MP0002877_abnormal_melanocyte_morpholog2.72163297
7MP0004272_abnormal_basement_membrane2.64465348
8MP0005360_urolithiasis2.52698876
9MP0005365_abnormal_bile_salt2.46413948
10MP0003252_abnormal_bile_duct2.44458806
11MP0009384_cardiac_valve_regurgitation2.43845291
12MP0003950_abnormal_plasma_membrane2.36332511
13MP0005085_abnormal_gallbladder_physiolo2.33925612
14MP0010234_abnormal_vibrissa_follicle2.31049199
15MP0003195_calcinosis2.13963216
16MP0002060_abnormal_skin_morphology2.03775563
17MP0000013_abnormal_adipose_tissue1.96305766
18MP0010368_abnormal_lymphatic_system1.95132051
19MP0003566_abnormal_cell_adhesion1.92728397
20MP0000516_abnormal_urinary_system1.90519143
21MP0005367_renal/urinary_system_phenotyp1.90519143
22MP0003279_aneurysm1.82545164
23MP0006054_spinal_hemorrhage1.76390046
24MP0002896_abnormal_bone_mineralization1.71303195
25MP0009780_abnormal_chondrocyte_physiolo1.67708914
26MP0005623_abnormal_meninges_morphology1.63613737
27MP0004215_abnormal_myocardial_fiber1.63413137
28MP0003300_gastrointestinal_ulcer1.63312485
29MP0005508_abnormal_skeleton_morphology1.62093441
30MP0008875_abnormal_xenobiotic_pharmacok1.61113611
31MP0003941_abnormal_skin_development1.59743340
32MP0010386_abnormal_urinary_bladder1.58285551
33MP0002837_dystrophic_cardiac_calcinosis1.57197460
34MP0003283_abnormal_digestive_organ1.57196919
35MP0005187_abnormal_penis_morphology1.56690661
36MP0004147_increased_porphyrin_level1.56573400
37MP0000579_abnormal_nail_morphology1.52602244
38MP0009053_abnormal_anal_canal1.52317304
39MP0004084_abnormal_cardiac_muscle1.51089332
40MP0001984_abnormal_olfaction1.47839103
41MP0006072_abnormal_retinal_apoptosis1.46049921
42MP0009697_abnormal_copulation1.43264463
43MP0001879_abnormal_lymphatic_vessel1.42411141
44MP0008775_abnormal_heart_ventricle1.42365950
45MP0001661_extended_life_span1.37670979
46MP0005220_abnormal_exocrine_pancreas1.37513795
47MP0005257_abnormal_intraocular_pressure1.37176894
48MP0002098_abnormal_vibrissa_morphology1.32932139
49MP0000538_abnormal_urinary_bladder1.31789141
50MP0005023_abnormal_wound_healing1.31491835
51MP0000003_abnormal_adipose_tissue1.30955261
52MP0001666_abnormal_nutrient_absorption1.29300931
53MP0002876_abnormal_thyroid_physiology1.29016555
54MP0000163_abnormal_cartilage_morphology1.28694699
55MP0009250_abnormal_appendicular_skeleto1.27408052
56MP0010030_abnormal_orbit_morphology1.26765307
57MP0000749_muscle_degeneration1.23920464
58MP0001243_abnormal_dermal_layer1.19560285
59MP0010329_abnormal_lipoprotein_level1.19183145
60MP0002108_abnormal_muscle_morphology1.18813020
61MP0002138_abnormal_hepatobiliary_system1.18661069
62MP0004145_abnormal_muscle_electrophysio1.17199219
63MP0002295_abnormal_pulmonary_circulatio1.16687069
64MP0010678_abnormal_skin_adnexa1.16337423
65MP0001944_abnormal_pancreas_morphology1.15228947
66MP0002102_abnormal_ear_morphology1.15162835
67MP0002282_abnormal_trachea_morphology1.14805745
68MP0001346_abnormal_lacrimal_gland1.12249817
69MP0005171_absent_coat_pigmentation1.11467316
70MP0000569_abnormal_digit_pigmentation1.09860086
71MP0002938_white_spotting1.09387077
72MP0003385_abnormal_body_wall1.09359438
73MP0000566_synostosis1.08732680
74MP0000383_abnormal_hair_follicle1.06849858
75MP0000537_abnormal_urethra_morphology1.06492773
76MP0004484_altered_response_of1.06267264
77MP0004036_abnormal_muscle_relaxation1.06133135
78MP0010352_gastrointestinal_tract_polyps1.04602283
79MP0000767_abnormal_smooth_muscle1.04162530
80MP0003942_abnormal_urinary_system1.03922507
81MP0002796_impaired_skin_barrier1.03766118
82MP0002168_other_aberrant_phenotype1.02645949
83MP0005248_abnormal_Harderian_gland1.02469047
84MP0003868_abnormal_feces_composition1.01692977
85MP0000762_abnormal_tongue_morphology1.01396123
86MP0005083_abnormal_biliary_tract1.01094659
87MP0005165_increased_susceptibility_to1.00991775
88MP0002115_abnormal_skeleton_extremities1.00837982
89MP0000678_abnormal_parathyroid_gland1.00735143
90MP0002254_reproductive_system_inflammat0.99397962
91MP0005390_skeleton_phenotype0.98949181
92MP0005620_abnormal_muscle_contractility0.98294710
93MP0002638_abnormal_pupillary_reflex0.97826075
94MP0003137_abnormal_impulse_conducting0.97139649
95MP0009643_abnormal_urine_homeostasis0.96124127
96MP0005253_abnormal_eye_physiology0.95808069
97MP0005330_cardiomyopathy0.95631188
98MP0004134_abnormal_chest_morphology0.94956505
99MP0001958_emphysema0.94784637
100MP0005595_abnormal_vascular_smooth0.94557204
101MP0000467_abnormal_esophagus_morphology0.92900971
102MP0001756_abnormal_urination0.92340662
103MP0004185_abnormal_adipocyte_glucose0.91039319
104MP0002751_abnormal_autonomic_nervous0.90925881
105MP0002090_abnormal_vision0.90356121
106MP0001299_abnormal_eye_distance/0.90134005
107MP0002928_abnormal_bile_duct0.89681839
108MP0000462_abnormal_digestive_system0.88736638
109MP0000377_abnormal_hair_follicle0.88150489
110MP0001270_distended_abdomen0.88105505
111MP0001216_abnormal_epidermal_layer0.87420728
112MP0005551_abnormal_eye_electrophysiolog0.87080105
113MP0003045_fibrosis0.86396521
114MP0003453_abnormal_keratinocyte_physiol0.86263567
115MP0002972_abnormal_cardiac_muscle0.85607091
116MP0005076_abnormal_cell_differentiation0.85481770
117MP0002234_abnormal_pharynx_morphology0.84232872
118MP0005375_adipose_tissue_phenotype0.83766713
119MP0002909_abnormal_adrenal_gland0.81835944
120MP0003091_abnormal_cell_migration0.80915336
121MP0005174_abnormal_tail_pigmentation0.80026616
122MP0004085_abnormal_heartbeat0.78999260
123MP0003935_abnormal_craniofacial_develop0.78820732
124MP0002118_abnormal_lipid_homeostasis0.78816789
125MP0004043_abnormal_pH_regulation0.78687413
126MP0002933_joint_inflammation0.78631593
127MP0000647_abnormal_sebaceous_gland0.78560777
128MP0000428_abnormal_craniofacial_morphol0.78539543
129MP0003795_abnormal_bone_structure0.78406040
130MP0003115_abnormal_respiratory_system0.77943580
131MP0005332_abnormal_amino_acid0.77731889
132MP0000613_abnormal_salivary_gland0.77550614
133MP0000751_myopathy0.77114620
134MP0009046_muscle_twitch0.76802419
135MP0003755_abnormal_palate_morphology0.76224483
136MP0000432_abnormal_head_morphology0.76096578
137MP0001542_abnormal_bone_strength0.75989548
138MP0002113_abnormal_skeleton_development0.74924629
139MP0000427_abnormal_hair_cycle0.74704425
140MP0000609_abnormal_liver_physiology0.74489669
141MP0002009_preneoplasia0.74221500
142MP0003937_abnormal_limbs/digits/tail_de0.73002993
143MP0002128_abnormal_blood_circulation0.71192981
144MP0000534_abnormal_ureter_morphology0.70848252

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.47627190
2Protrusio acetabuli (HP:0003179)4.31007868
3Deep venous thrombosis (HP:0002625)3.73558825
4Atrophic scars (HP:0001075)3.59873083
5Hypoglycemic coma (HP:0001325)3.57959167
6Right ventricular cardiomyopathy (HP:0011663)3.37212620
7Intrahepatic cholestasis (HP:0001406)3.33362968
8Xanthomatosis (HP:0000991)3.20747540
9Abnormality of the intrinsic pathway (HP:0010989)3.13400277
10Hyperinsulinemic hypoglycemia (HP:0000825)3.05674090
11Hypoglycemic seizures (HP:0002173)3.01519184
12Abnormality of the common coagulation pathway (HP:0010990)3.00590988
13Focal segmental glomerulosclerosis (HP:0000097)2.97905562
14Abnormality of monocarboxylic acid metabolism (HP:0010996)2.95380214
15Aortic dissection (HP:0002647)2.94411559
16Prolonged partial thromboplastin time (HP:0003645)2.92940401
17Vascular tortuosity (HP:0004948)2.87526855
18Hydroxyprolinuria (HP:0003080)2.87070768
19Abnormality of proline metabolism (HP:0010907)2.87070768
20Abnormality of aromatic amino acid family metabolism (HP:0004338)2.85077756
21Peritonitis (HP:0002586)2.82989652
22Neonatal short-limb short stature (HP:0008921)2.80227000
23Symptomatic seizures (HP:0011145)2.77719450
24Broad metatarsal (HP:0001783)2.75933233
25Aortic aneurysm (HP:0004942)2.71336555
26Hyperglycemia (HP:0003074)2.68750279
27Metaphyseal dysplasia (HP:0100255)2.67024239
28Shallow orbits (HP:0000586)2.65945785
29Abnormality of dentin (HP:0010299)2.64241096
30Arterial tortuosity (HP:0005116)2.57430667
31Fragile skin (HP:0001030)2.57109743
32Myocardial infarction (HP:0001658)2.45111124
33Cardiovascular calcification (HP:0011915)2.44914745
34Delayed gross motor development (HP:0002194)2.43179020
35Cervical subluxation (HP:0003308)2.39950650
36Hypothermia (HP:0002045)2.38403587
37Ankle contracture (HP:0006466)2.37291292
38Hamartoma of the eye (HP:0010568)2.36048377
39Glomerulosclerosis (HP:0000096)2.34751276
40Mitral valve prolapse (HP:0001634)2.34477677
41Mesangial abnormality (HP:0001966)2.33032192
42Pheochromocytoma (HP:0002666)2.31518198
43Postural tremor (HP:0002174)2.30525512
44Patchy hypopigmentation of hair (HP:0011365)2.23890297
45Nephritis (HP:0000123)2.23206284
46Mitral stenosis (HP:0001718)2.21596168
47Hyperlipoproteinemia (HP:0010980)2.19960012
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.19684743
49Osteolytic defects of the hand bones (HP:0009699)2.19684743
50Soft skin (HP:0000977)2.19487009
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15779432
52Abnormal foot bone ossification (HP:0010675)2.13049194
53Aneurysm (HP:0002617)2.12879987
54Blue sclerae (HP:0000592)2.12217165
55Thin bony cortex (HP:0002753)2.11735769
56Keratoconus (HP:0000563)2.10408787
57Increased corneal curvature (HP:0100692)2.10408787
58Dilatation of the ascending aorta (HP:0005111)2.10392898
59Hypoalphalipoproteinemia (HP:0003233)2.09931102
60Action tremor (HP:0002345)2.09858269
61Coronal craniosynostosis (HP:0004440)2.08811323
62Vascular calcification (HP:0004934)2.07047537
63Palpitations (HP:0001962)2.05815123
64Ectopia lentis (HP:0001083)2.05634460
65Abnormal tarsal ossification (HP:0008369)2.04933121
66Abdominal distention (HP:0003270)2.04874168
67Abnormality of vitamin B metabolism (HP:0004340)2.04524429
68Scanning speech (HP:0002168)2.03799851
69Hemiparesis (HP:0001269)2.03686716
70Bowel diverticulosis (HP:0005222)2.03135913
71Abnormal albumin level (HP:0012116)2.01803038
72Hypoalbuminemia (HP:0003073)2.01803038
73Joint hemorrhage (HP:0005261)2.00587342
74Tibial bowing (HP:0002982)1.99950007
75Congenital malformation of the right heart (HP:0011723)1.99716726
76Double outlet right ventricle (HP:0001719)1.99716726
77Protuberant abdomen (HP:0001538)1.98738939
78Hypoplastic ischia (HP:0003175)1.98726715
79Intestinal atresia (HP:0011100)1.97135587
80Cerebral aneurysm (HP:0004944)1.96949134
81Cupped ribs (HP:0000887)1.96780671
82Insulin-resistant diabetes mellitus (HP:0000831)1.96166637
83Turricephaly (HP:0000262)1.95746853
84Bronchomalacia (HP:0002780)1.95046722
85Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94680776
86Wormian bones (HP:0002645)1.94168761
87Skin nodule (HP:0200036)1.94110706
88Neuroendocrine neoplasm (HP:0100634)1.93791441
89Overgrowth (HP:0001548)1.93391736
90Conjugated hyperbilirubinemia (HP:0002908)1.92760238
91Buphthalmos (HP:0000557)1.92244970
92Glomerulonephritis (HP:0000099)1.91784062
93Ketoacidosis (HP:0001993)1.90951900
94Complement deficiency (HP:0004431)1.90547996
95Exostoses (HP:0100777)1.89885480
96Abnormality of the ischium (HP:0003174)1.88410817
97Spinal rigidity (HP:0003306)1.88373039
98Abnormal delivery (HP:0001787)1.86945747
99Late onset (HP:0003584)1.86758166
100Conjunctival hamartoma (HP:0100780)1.84181213
101Fat malabsorption (HP:0002630)1.84087514
102Epidermoid cyst (HP:0200040)1.83347808
103Hypolipoproteinemia (HP:0010981)1.82967583
104Onycholysis (HP:0001806)1.82485637
105Wide anterior fontanel (HP:0000260)1.82368782
106Disproportionate short-trunk short stature (HP:0003521)1.82066849
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.81673174
108Hypercholesterolemia (HP:0003124)1.81594993
109Back pain (HP:0003418)1.80937313
110Osteoarthritis (HP:0002758)1.80562110
111Breast carcinoma (HP:0003002)1.79993759
112Femoral bowing (HP:0002980)1.79821014
113Asymmetry of the thorax (HP:0001555)1.79750476
114Limited hip movement (HP:0008800)1.79203301
115Increased connective tissue (HP:0009025)1.79167136
116Infantile muscular hypotonia (HP:0008947)1.79128125
117Lymphangioma (HP:0100764)1.79047159
118Short tibia (HP:0005736)1.78683671
119Hypobetalipoproteinemia (HP:0003563)1.77751446
120Genu recurvatum (HP:0002816)1.77656612
121Fragile nails (HP:0001808)1.77456299
122Bifid tongue (HP:0010297)1.77312876
123Neoplasm of the adrenal gland (HP:0100631)1.77208272
124Bladder diverticulum (HP:0000015)1.76525537
125Gingival overgrowth (HP:0000212)1.76415440
126Mildly elevated creatine phosphokinase (HP:0008180)1.76341705
127Intention tremor (HP:0002080)1.76208371
128Follicular hyperkeratosis (HP:0007502)1.75853843
129Mesomelia (HP:0003027)1.74717975
130Biconcave vertebral bodies (HP:0004586)1.74321199
131Short nail (HP:0001799)1.74232066
132Flat acetabular roof (HP:0003180)1.73793692
133Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72273118
134Posterior subcapsular cataract (HP:0007787)1.72221674
135Advanced eruption of teeth (HP:0006288)1.72184352
136Pancreatic islet-cell hyperplasia (HP:0004510)1.70097732
137Thoracolumbar scoliosis (HP:0002944)1.68348719
138Abnormality of vitamin metabolism (HP:0100508)1.68209949
139Hyperextensible skin (HP:0000974)1.67971680
140Ketosis (HP:0001946)1.67563150
141Breech presentation (HP:0001623)1.67250449
142Abnormality of endocrine pancreas physiology (HP:0012093)1.66609713
143Abnormality of the pancreatic islet cells (HP:0006476)1.66609713
144Pulmonary artery stenosis (HP:0004415)1.63877655
145Congenital sensorineural hearing impairment (HP:0008527)1.63279498
146Pigmentary retinal degeneration (HP:0001146)1.63067503
147Progressive macrocephaly (HP:0004481)1.61795383
148Abnormality of the vitamin B12 metabolism (HP:0004341)1.61437450
149Abnormality of the calf musculature (HP:0001430)1.61310628
150Neoplasm of the peripheral nervous system (HP:0100007)1.59984187
151White forelock (HP:0002211)1.59462174
152Reduced subcutaneous adipose tissue (HP:0003758)1.58858051
153Hematochezia (HP:0002573)1.58347072
154Hypoplasia of the odontoid process (HP:0003311)1.57940811
155Chorioretinal atrophy (HP:0000533)1.56676521
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.56240984
157Pancreatic fibrosis (HP:0100732)1.56122006
158Metabolic alkalosis (HP:0200114)1.55344581
159Spondylolisthesis (HP:0003302)1.55098579
160Abnormality of aspartate family amino acid metabolism (HP:0010899)1.54401078
161Arthropathy (HP:0003040)1.53568173
162Abnormality of the acetabulum (HP:0003170)1.52750891
163Bone cyst (HP:0012062)1.51435235
164Type 1 muscle fiber predominance (HP:0003803)1.49281543
165Neoplasm of the adrenal cortex (HP:0100641)1.47992565
166Congenital glaucoma (HP:0001087)1.47274814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.58037944
2LATS13.30682817
3ERN13.06249775
4SIK12.75526380
5EPHB22.75201955
6PLK22.70917806
7TRIB32.68423458
8TNIK2.50635748
9EIF2AK12.49339481
10FRK2.48356915
11EIF2AK32.45927777
12PDGFRA2.34640390
13TAOK32.31909824
14EPHA32.25671689
15DDR22.22865685
16PIK3CA2.20417583
17MST1R2.15905772
18PTK62.12825807
19MST41.95423104
20VRK21.95335543
21TAF11.94907394
22STK391.94088467
23FER1.86006693
24PTK21.84237246
25MET1.83502101
26ACVR1B1.76114407
27FGFR41.73212502
28MAP3K31.66553982
29TTN1.66187664
30AKT31.59682748
31MAPK151.59526396
32TGFBR21.57131867
33NEK91.56355921
34TRPM71.53031348
35MKNK21.51076467
36STK31.50184536
37GRK11.43929749
38FLT31.41851643
39NUAK11.41129612
40PIK3CG1.40605051
41RIPK11.40568864
42MAP3K21.39172590
43CASK1.38356075
44LIMK11.37715192
45CSNK1G11.33046816
46PKN21.31754699
47CSNK1G31.31227235
48NEK11.29935808
49EPHB11.29316645
50PLK31.28140862
51WNK41.28076561
52PHKG11.27472642
53PHKG21.27472642
54PAK21.27397202
55MAP3K121.26396265
56FGFR21.23652682
57HIPK21.21314095
58BRSK21.19877725
59PAK31.19679015
60CSNK1G21.18535676
61MKNK11.18450549
62MYLK1.17478202
63TIE11.17172468
64MAP4K21.12482787
65CSNK1A1L1.11695403
66CAMK2D1.11613620
67PASK1.11390726
68IRAK31.09289519
69CDK61.06948768
70LMTK21.06593352
71MAPKAPK51.05420406
72DYRK1B1.04169035
73KDR1.03620943
74DMPK0.97473128
75PDGFRB0.96375159
76STK38L0.96369242
77GRK50.90981604
78OXSR10.90311144
79WEE10.89510584
80LRRK20.88336373
81ROCK20.87995035
82OBSCN0.87470695
83PNCK0.86263393
84FGFR30.86249331
85ERBB30.85514410
86EPHA20.84892250
87TRIM280.84658263
88FGFR10.83730336
89PTK2B0.81481574
90MTOR0.78875071
91TGFBR10.74961394
92EIF2AK20.74062928
93JAK10.73965705
94ROCK10.73528663
95CAMK1D0.72930518
96IGF1R0.72044532
97STK240.71138141
98GSK3A0.71060745
99PRKD10.70659299
100PAK40.69529931
101IRAK10.67061357
102ADRBK20.66840133
103ERBB20.66332817
104ERBB40.65066392
105BMX0.63380683
106CDC42BPA0.63311536
107NTRK30.61878286
108PBK0.61773980
109PDK20.60902946
110PLK40.60864159
111NTRK10.60673690
112CHUK0.60229108
113CAMK2A0.59528104
114TTK0.59272844
115BCKDK0.59078922
116CAMK2G0.58734387
117CAMK1G0.58502234
118RPS6KA40.57318023
119MAP3K10.56782783
120PRKD20.56181596
121ILK0.56151395
122MUSK0.55553061
123PRKCH0.55469543
124PRKG20.54976383
125CSK0.54860197
126NLK0.54752623
127PIM20.52921963
128MAPK110.52907429
129WNK30.52066210
130WNK10.51213433
131EPHA40.50988989
132RET0.50868965
133JAK20.50786199
134CDK120.50400229
135PINK10.49193815
136MAP2K10.49019660
137STK100.48630966
138ZAK0.48545267
139ABL20.47427554
140RAF10.47096590
141PRKAA20.46352290
142INSR0.46020221
143VRK10.43845192
144MAP2K20.42994343
145MAPKAPK30.42628830
146JAK30.41994970
147BMPR20.41602900
148MAP3K140.40650125
149PRKCE0.39811187
150PRKG10.39507837
151LATS20.38130346
152BMPR1B0.37172171
153PRKAA10.36235263
154ITK0.35930882
155MAPKAPK20.31127760
156BCR0.31080511

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.92435211
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.76202834
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63857429
4ECM-receptor interaction_Homo sapiens_hsa045122.49701943
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44771366
6Sulfur metabolism_Homo sapiens_hsa009202.39557306
7Complement and coagulation cascades_Homo sapiens_hsa046102.34233714
8Nitrogen metabolism_Homo sapiens_hsa009102.19569037
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17507715
10Tryptophan metabolism_Homo sapiens_hsa003802.16952956
11Fatty acid degradation_Homo sapiens_hsa000712.00127606
12Mineral absorption_Homo sapiens_hsa049781.97185661
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76447233
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74577517
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.73567927
16Protein digestion and absorption_Homo sapiens_hsa049741.63058873
17Chemical carcinogenesis_Homo sapiens_hsa052041.61482690
18Starch and sucrose metabolism_Homo sapiens_hsa005001.59253908
19Histidine metabolism_Homo sapiens_hsa003401.57549434
20Focal adhesion_Homo sapiens_hsa045101.55600019
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54388692
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.53880521
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52308819
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48821215
25Retinol metabolism_Homo sapiens_hsa008301.47349792
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46409785
27Vitamin B6 metabolism_Homo sapiens_hsa007501.44069879
28PPAR signaling pathway_Homo sapiens_hsa033201.40817212
29Lysine degradation_Homo sapiens_hsa003101.38640626
30Arginine biosynthesis_Homo sapiens_hsa002201.36795809
31Selenocompound metabolism_Homo sapiens_hsa004501.36285311
32Protein export_Homo sapiens_hsa030601.34567961
33Caffeine metabolism_Homo sapiens_hsa002321.32988738
34Amoebiasis_Homo sapiens_hsa051461.27117099
35Fatty acid metabolism_Homo sapiens_hsa012121.26098928
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24670426
37Adherens junction_Homo sapiens_hsa045201.23750960
38Phenylalanine metabolism_Homo sapiens_hsa003601.23171456
39ABC transporters_Homo sapiens_hsa020101.21157604
40Bladder cancer_Homo sapiens_hsa052191.20447510
41Bile secretion_Homo sapiens_hsa049761.17720043
42Proteoglycans in cancer_Homo sapiens_hsa052051.13190185
43Peroxisome_Homo sapiens_hsa041461.11257366
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09437460
45Small cell lung cancer_Homo sapiens_hsa052221.07517847
46Proteasome_Homo sapiens_hsa030501.07304353
47Tyrosine metabolism_Homo sapiens_hsa003501.07168858
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06762771
49Insulin resistance_Homo sapiens_hsa049311.03748320
50Staphylococcus aureus infection_Homo sapiens_hsa051501.01652782
51Fat digestion and absorption_Homo sapiens_hsa049751.00438970
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99132659
53Pyruvate metabolism_Homo sapiens_hsa006200.97997177
54Renin secretion_Homo sapiens_hsa049240.97189531
55Butanoate metabolism_Homo sapiens_hsa006500.95203653
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.94470483
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94366867
58Insulin secretion_Homo sapiens_hsa049110.94273951
59Circadian rhythm_Homo sapiens_hsa047100.94124117
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88502322
61Folate biosynthesis_Homo sapiens_hsa007900.87568961
62Fructose and mannose metabolism_Homo sapiens_hsa000510.86394796
63beta-Alanine metabolism_Homo sapiens_hsa004100.85231427
64Pancreatic secretion_Homo sapiens_hsa049720.85061367
65TGF-beta signaling pathway_Homo sapiens_hsa043500.84461785
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84080982
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83281853
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81811394
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79853297
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79806727
71Ether lipid metabolism_Homo sapiens_hsa005650.77609967
72Linoleic acid metabolism_Homo sapiens_hsa005910.76981274
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76508215
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75970236
75Basal cell carcinoma_Homo sapiens_hsa052170.75673665
76Propanoate metabolism_Homo sapiens_hsa006400.75312447
77Dilated cardiomyopathy_Homo sapiens_hsa054140.74952694
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.74502184
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73925073
80Renin-angiotensin system_Homo sapiens_hsa046140.69793605
81Prostate cancer_Homo sapiens_hsa052150.68666091
82Carbon metabolism_Homo sapiens_hsa012000.65127273
83N-Glycan biosynthesis_Homo sapiens_hsa005100.64802678
84Fatty acid elongation_Homo sapiens_hsa000620.63254991
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62947098
86Chronic myeloid leukemia_Homo sapiens_hsa052200.60563881
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60005186
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59988594
89Salivary secretion_Homo sapiens_hsa049700.59957926
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.59643036
91One carbon pool by folate_Homo sapiens_hsa006700.57911433
92Hippo signaling pathway_Homo sapiens_hsa043900.57692351
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57358238
94Oxidative phosphorylation_Homo sapiens_hsa001900.57010106
95Alzheimers disease_Homo sapiens_hsa050100.55931488
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55492566
97MicroRNAs in cancer_Homo sapiens_hsa052060.54627986
98Metabolic pathways_Homo sapiens_hsa011000.52395858
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52206068
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51349141
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50477328
102Vitamin digestion and absorption_Homo sapiens_hsa049770.49914966
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48932135
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48499164
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48453746
106Glucagon signaling pathway_Homo sapiens_hsa049220.47061572
107Malaria_Homo sapiens_hsa051440.46896526
108Ovarian steroidogenesis_Homo sapiens_hsa049130.46860248
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46757775
110Thyroid hormone synthesis_Homo sapiens_hsa049180.46521891
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.45392385
112Non-homologous end-joining_Homo sapiens_hsa034500.45159688
113Long-term depression_Homo sapiens_hsa047300.44831062
114Cardiac muscle contraction_Homo sapiens_hsa042600.43752566
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.43690260
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.43342445
117Type II diabetes mellitus_Homo sapiens_hsa049300.42696219
118Arachidonic acid metabolism_Homo sapiens_hsa005900.42473404
119Parkinsons disease_Homo sapiens_hsa050120.41835164
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41794558
121Tight junction_Homo sapiens_hsa045300.41573240
122Melanoma_Homo sapiens_hsa052180.41481631
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41444057
124Platelet activation_Homo sapiens_hsa046110.39302051
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37740145
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37131104
127AMPK signaling pathway_Homo sapiens_hsa041520.36753014
128Steroid biosynthesis_Homo sapiens_hsa001000.36124548
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36083261
130Pancreatic cancer_Homo sapiens_hsa052120.34033080
131Hedgehog signaling pathway_Homo sapiens_hsa043400.33929911
132Glutathione metabolism_Homo sapiens_hsa004800.33923885
133Arginine and proline metabolism_Homo sapiens_hsa003300.33502949
134Galactose metabolism_Homo sapiens_hsa000520.33092780
135Pathways in cancer_Homo sapiens_hsa052000.31926083
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.31579315
137Toxoplasmosis_Homo sapiens_hsa051450.30464115
138Sphingolipid metabolism_Homo sapiens_hsa006000.30443172

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