GOLM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.60404909
2lung epithelium development (GO:0060428)5.45851302
3chondrocyte proliferation (GO:0035988)4.57832070
4epithelial cell fate commitment (GO:0072148)4.56746996
5lens fiber cell development (GO:0070307)4.52450143
6paraxial mesoderm development (GO:0048339)4.33948971
7embryonic foregut morphogenesis (GO:0048617)4.30699388
8maintenance of gastrointestinal epithelium (GO:0030277)4.20169304
9axon extension involved in axon guidance (GO:0048846)4.13891740
10neuron projection extension involved in neuron projection guidance (GO:1902284)4.13891740
11renal system development (GO:0072001)4.12148912
12epithelial cell differentiation involved in prostate gland development (GO:0060742)4.09469412
13positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.02127189
14regulation of chemokine secretion (GO:0090196)3.89301622
15axonemal dynein complex assembly (GO:0070286)3.80898632
16negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.76535705
17epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.76530784
18apical protein localization (GO:0045176)3.66460065
19regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.63366732
20apoptotic process involved in morphogenesis (GO:0060561)3.56216483
21lens morphogenesis in camera-type eye (GO:0002089)3.52729738
22embryonic camera-type eye development (GO:0031076)3.51481865
23cytoskeletal anchoring at plasma membrane (GO:0007016)3.48974137
24midgut development (GO:0007494)3.43919511
25epithelial structure maintenance (GO:0010669)3.43062362
26protein retention in ER lumen (GO:0006621)3.38311767
27positive regulation of SMAD protein import into nucleus (GO:0060391)3.36405974
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.34930589
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32300499
30barbed-end actin filament capping (GO:0051016)3.28718113
31microglial cell activation (GO:0001774)3.28288832
32positive regulation of chemokine secretion (GO:0090197)3.26877650
33regulation of SMAD protein import into nucleus (GO:0060390)3.22329248
34negative regulation of glial cell proliferation (GO:0060253)3.19389964
35atrioventricular valve morphogenesis (GO:0003181)3.17333427
36heart valve formation (GO:0003188)3.16853688
37negative regulation of chondrocyte differentiation (GO:0032331)3.16618446
38somite development (GO:0061053)3.15551252
39asymmetric protein localization (GO:0008105)3.10366898
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.10163350
41regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.06414819
42neuronal stem cell maintenance (GO:0097150)3.05235903
43establishment or maintenance of apical/basal cell polarity (GO:0035088)3.03306846
44establishment or maintenance of bipolar cell polarity (GO:0061245)3.03306846
45endocardial cushion morphogenesis (GO:0003203)3.01396910
46nodal signaling pathway (GO:0038092)3.00648328
47regulation of T cell tolerance induction (GO:0002664)2.97790046
48COPI coating of Golgi vesicle (GO:0048205)2.97073497
49Golgi transport vesicle coating (GO:0048200)2.97073497
50regulation of posttranscriptional gene silencing (GO:0060147)2.96422873
51regulation of gene silencing by miRNA (GO:0060964)2.96422873
52regulation of gene silencing by RNA (GO:0060966)2.96422873
53cell surface receptor signaling pathway involved in heart development (GO:0061311)2.94553794
54sodium ion export (GO:0071436)2.93363140
55negative regulation of epidermis development (GO:0045683)2.93361325
56respiratory tube development (GO:0030323)2.93217269
57positive regulation of epithelial to mesenchymal transition (GO:0010718)2.90112001
58cellular potassium ion homeostasis (GO:0030007)2.88576195
59DNA unwinding involved in DNA replication (GO:0006268)2.87138472
60regulation of transforming growth factor beta2 production (GO:0032909)2.86993699
61intestinal epithelial cell development (GO:0060576)2.85622424
62Notch signaling involved in heart development (GO:0061314)2.84784649
63mesenchymal to epithelial transition (GO:0060231)2.84384502
64regulation of hippo signaling (GO:0035330)2.84022229
65coronary vasculature morphogenesis (GO:0060977)2.82751555
66cell migration involved in heart development (GO:0060973)2.80927128
67embryonic viscerocranium morphogenesis (GO:0048703)2.79893684
68establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.79642086
69positive regulation of astrocyte differentiation (GO:0048711)2.78971658
70camera-type eye morphogenesis (GO:0048593)2.78703409
71regulation of glial cell proliferation (GO:0060251)2.78699863
72regulation of stem cell maintenance (GO:2000036)2.76942070
73lung-associated mesenchyme development (GO:0060484)2.76235665
74mating behavior (GO:0007617)2.74037776
75collecting duct development (GO:0072044)2.73838031
76axonal fasciculation (GO:0007413)2.73622152
77lung lobe morphogenesis (GO:0060463)2.73131160
78negative regulation of oligodendrocyte differentiation (GO:0048715)2.72257859
79hindlimb morphogenesis (GO:0035137)2.71848408
80positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.71327864
81thalamus development (GO:0021794)2.70840161
82establishment of planar polarity (GO:0001736)2.68032930
83establishment of tissue polarity (GO:0007164)2.68032930
84Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.67521484
85apoptotic process involved in development (GO:1902742)2.65610639
86ventricular trabecula myocardium morphogenesis (GO:0003222)2.64963630
87response to muramyl dipeptide (GO:0032495)2.63462104
88neuron recognition (GO:0008038)2.63294811
89layer formation in cerebral cortex (GO:0021819)2.61281207
90G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.60572855
91dosage compensation (GO:0007549)2.58315841
92postsynaptic membrane organization (GO:0001941)2.57270907
93regulation of establishment of planar polarity (GO:0090175)2.56863176
94venous blood vessel morphogenesis (GO:0048845)2.56122843
95nuclear pore organization (GO:0006999)2.55253041
96regulation of telomere maintenance via telomerase (GO:0032210)2.54527325
97presynaptic membrane assembly (GO:0097105)2.54181240
98hepatocyte apoptotic process (GO:0097284)2.53401051
99notochord development (GO:0030903)2.53272820
100cilium or flagellum-dependent cell motility (GO:0001539)2.53067645
101positive regulation of keratinocyte differentiation (GO:0045618)2.52958904
102negative regulation of catenin import into nucleus (GO:0035414)2.52688251
103developmental programmed cell death (GO:0010623)2.51377248
104epithelial cell-cell adhesion (GO:0090136)2.50594917
105positive regulation of BMP signaling pathway (GO:0030513)2.50150704
106dopaminergic neuron differentiation (GO:0071542)2.49941132
107negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.49284226
108semaphorin-plexin signaling pathway (GO:0071526)2.47761082
109membrane assembly (GO:0071709)2.47708183
110nuclear pore complex assembly (GO:0051292)2.46788291
111endoderm development (GO:0007492)2.46745990
112positive regulation of tolerance induction (GO:0002645)2.45220496
113heterochromatin organization (GO:0070828)2.45196961
114regulation of somitogenesis (GO:0014807)2.45070290
115cochlea morphogenesis (GO:0090103)2.44925766
116pore complex assembly (GO:0046931)2.44536346
117regulation of extracellular matrix organization (GO:1903053)2.43890052
118hippo signaling (GO:0035329)2.42514544
119establishment of apical/basal cell polarity (GO:0035089)2.42434969
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41781027
121activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.41080571
122cilium movement (GO:0003341)2.40596268
123outer ear morphogenesis (GO:0042473)2.40433945
124UDP-N-acetylglucosamine metabolic process (GO:0006047)2.40364433
125hemidesmosome assembly (GO:0031581)2.39736552
126negative regulation of cartilage development (GO:0061037)2.39630729
127cellular sodium ion homeostasis (GO:0006883)2.37841379
128retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37565969
129negative regulation of granulocyte differentiation (GO:0030853)2.37499774
130mitotic nuclear envelope disassembly (GO:0007077)2.35758561
131epithelial tube branching involved in lung morphogenesis (GO:0060441)2.34889556
132vocalization behavior (GO:0071625)2.34502417
133somatic stem cell division (GO:0048103)2.34399384
134axon extension (GO:0048675)2.33623288
135bone morphogenesis (GO:0060349)2.33519105
136protein localization to kinetochore (GO:0034501)2.33313083
137mesenchyme morphogenesis (GO:0072132)2.33097307
138signal transduction involved in regulation of gene expression (GO:0023019)2.32813554
139ephrin receptor signaling pathway (GO:0048013)2.30418046
140mesenchymal cell proliferation (GO:0010463)2.30230924
141convergent extension (GO:0060026)2.30189343
142presynaptic membrane organization (GO:0097090)2.26902256
143establishment or maintenance of monopolar cell polarity (GO:0061339)2.24538878
144establishment of monopolar cell polarity (GO:0061162)2.24538878
145negative regulation of keratinocyte proliferation (GO:0010839)2.21731043
146endothelial cell chemotaxis (GO:0035767)2.21032689
147cerebellar Purkinje cell layer development (GO:0021680)2.20539579
148dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.20369684
149renal filtration (GO:0097205)2.20341641
150regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.20258472
151establishment of nucleus localization (GO:0040023)2.20233576
152regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.19532690
153embryonic retina morphogenesis in camera-type eye (GO:0060059)2.19521474
154peripheral nervous system axon ensheathment (GO:0032292)2.16355279
155myelination in peripheral nervous system (GO:0022011)2.16355279
156positive regulation of smoothened signaling pathway (GO:0045880)2.16329280
157Sertoli cell development (GO:0060009)2.16117176
158synaptic vesicle docking involved in exocytosis (GO:0016081)2.15358946
159sodium ion homeostasis (GO:0055078)2.15357400
160lateral sprouting from an epithelium (GO:0060601)2.15232199
161nephron tubule formation (GO:0072079)2.15054415
162axon ensheathment in central nervous system (GO:0032291)2.14248664
163central nervous system myelination (GO:0022010)2.14248664
164motile cilium assembly (GO:0044458)2.13833935
165neuron remodeling (GO:0016322)2.13470891
166skeletal muscle organ development (GO:0060538)2.12536946
167muscle cell migration (GO:0014812)2.11909225
168regulation of axon extension involved in axon guidance (GO:0048841)2.11404873
169neuron cell-cell adhesion (GO:0007158)2.10505158
170regulation of short-term neuronal synaptic plasticity (GO:0048172)2.10047288
171neuron projection regeneration (GO:0031102)2.08976456
172neuron projection extension (GO:1990138)2.08840096
173cell-cell junction maintenance (GO:0045217)2.08030117
174non-canonical Wnt signaling pathway (GO:0035567)2.06550291
175primary alcohol catabolic process (GO:0034310)2.05406458
176cell communication by electrical coupling (GO:0010644)2.03733996
177epithelial cilium movement (GO:0003351)2.01540612
178ectodermal placode formation (GO:0060788)2.01419391
179calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.01299402
180glomerular filtration (GO:0003094)2.01079697
181gap junction assembly (GO:0016264)2.01022684
182left/right pattern formation (GO:0060972)1.99853787
183O-glycan processing (GO:0016266)1.99542083
184regulation of axon guidance (GO:1902667)1.97755327
185developmental cell growth (GO:0048588)1.97470597
186cGMP-mediated signaling (GO:0019934)1.96964626
187neuromuscular junction development (GO:0007528)1.96959886
188myoblast fusion (GO:0007520)1.96693100
189glomerular epithelial cell development (GO:0072310)1.96477612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.70314889
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.06317609
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.67793084
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.15143395
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.18041466
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88435929
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71870577
8AR_21909140_ChIP-Seq_LNCAP_Human2.70225882
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46311571
10EZH2_22144423_ChIP-Seq_EOC_Human2.37813608
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.34924432
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34790347
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.34727149
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33192875
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.22915729
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20915420
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14092721
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.08730811
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.06712861
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.02124727
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.01870246
22MYC_22102868_ChIP-Seq_BL_Human2.00795602
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98301135
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.98223030
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.95623677
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.95623677
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.95623677
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94619463
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94619463
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94549949
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91859862
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87742099
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.86943357
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.81552353
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81282264
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.80682932
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78431418
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73849692
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71499927
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70203151
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.69613314
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.69313547
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.69064356
44VDR_21846776_ChIP-Seq_THP-1_Human1.67915973
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63130137
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62802110
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60176925
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60175842
49* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58728274
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57756667
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56092560
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56012168
53XRN2_22483619_ChIP-Seq_HELA_Human1.54530805
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53732527
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.53006505
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.52939130
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52719128
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51752570
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49607512
60* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48768725
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.47822611
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47431270
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47400188
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.47052762
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45927556
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.45298108
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44708947
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44385906
69* ELK3_25401928_ChIP-Seq_HUVEC_Human1.43799112
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42917580
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42559231
72CLOCK_20551151_ChIP-Seq_293T_Human1.42117172
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40876463
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39808971
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39773378
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39250016
77GATA6_25053715_ChIP-Seq_YYC3_Human1.38708455
78TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38353178
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37250498
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36083312
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.35661006
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34876267
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34388539
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.33972437
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33808629
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32967754
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31259077
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29884728
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29047007
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28719487
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.28567376
92KDM2B_26808549_Chip-Seq_K562_Human1.28381452
93* DROSHA_22980978_ChIP-Seq_HELA_Human1.27961470
94MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27025256
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26952295
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26800938
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26262905
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25154938
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21516655
100ZNF263_19887448_ChIP-Seq_K562_Human1.21052975
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20693585
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20189860
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.18608589
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.18260562
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17710069
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.17460329
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17314103
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17232392
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16987514
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15382153
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.15285898
112TCF7_22412390_ChIP-Seq_EML_Mouse1.13604320
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.13447420
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13365138
115* GATA4_25053715_ChIP-Seq_YYC3_Human1.10271279
116TP53_20018659_ChIP-ChIP_R1E_Mouse1.09788222
117EP300_21415370_ChIP-Seq_HL-1_Mouse1.09593774
118* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09515638
119ATF3_27146783_Chip-Seq_COLON_Human1.09406660
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08922359
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08846508
122NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08591176
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08171365
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08156825
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08123148
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08090811
127* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08060259
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07483890
129RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07477020
130SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07463885
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06316195
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05926312
133KLF5_25053715_ChIP-Seq_YYC3_Human1.05501316
134TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05073199
135RUNX1_27514584_Chip-Seq_MCF-7_Human1.03893365
136* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03657302
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02794896
138ESR2_21235772_ChIP-Seq_MCF-7_Human1.01494582
139SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01386036
140CIITA_25753668_ChIP-Seq_RAJI_Human1.01234308
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00666184
142* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99629575
143TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99464147
144RACK7_27058665_Chip-Seq_MCF-7_Human0.98610873
145RARB_27405468_Chip-Seq_BRAIN_Mouse0.98524323
146NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98007796
147POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97906535
148POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97895516
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96000760
150RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95616317
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95525433
152RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95349612
153KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95144009
154ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95134336
155NANOG_21062744_ChIP-ChIP_HESCs_Human0.95115541
156SOX2_20726797_ChIP-Seq_SW620_Human0.94525543
157SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93780741
158MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92301457
159THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91838664
160SALL1_21062744_ChIP-ChIP_HESCs_Human0.91754198
161SPI1_23127762_ChIP-Seq_K562_Human0.91699057
162TET1_21490601_ChIP-Seq_MESCs_Mouse0.91353476
163PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90820114
164NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90803080
165KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90338524
166KDM2B_26808549_Chip-Seq_DND41_Human0.89851278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.19171263
2MP0010030_abnormal_orbit_morphology4.05832143
3MP0008004_abnormal_stomach_pH3.09900761
4MP0000537_abnormal_urethra_morphology2.96572875
5MP0010234_abnormal_vibrissa_follicle2.94466659
6MP0009053_abnormal_anal_canal2.74620150
7MP0006054_spinal_hemorrhage2.62957699
8MP0009780_abnormal_chondrocyte_physiolo2.56327639
9MP0003283_abnormal_digestive_organ2.52871399
10MP0004264_abnormal_extraembryonic_tissu2.48032023
11MP0009379_abnormal_foot_pigmentation2.47231923
12MP0004858_abnormal_nervous_system2.41741610
13MP0003693_abnormal_embryo_hatching2.22624366
14MP0005623_abnormal_meninges_morphology2.16073886
15MP0010352_gastrointestinal_tract_polyps2.14503840
16MP0000778_abnormal_nervous_system2.11559631
17MP0005257_abnormal_intraocular_pressure2.03313781
18MP0001873_stomach_inflammation1.97873600
19MP0004859_abnormal_synaptic_plasticity1.96376213
20MP0003705_abnormal_hypodermis_morpholog1.89361049
21MP0000490_abnormal_crypts_of1.88186473
22MP0003136_yellow_coat_color1.79263214
23MP0008007_abnormal_cellular_replicative1.79226344
24MP0004270_analgesia1.74784046
25MP0005076_abnormal_cell_differentiation1.73382988
26MP0002653_abnormal_ependyma_morphology1.73032113
27MP0002089_abnormal_postnatal_growth/wei1.72348667
28MP0004957_abnormal_blastocyst_morpholog1.72059706
29MP0002102_abnormal_ear_morphology1.70504977
30MP0003077_abnormal_cell_cycle1.67701840
31MP0003111_abnormal_nucleus_morphology1.67696769
32MP0000462_abnormal_digestive_system1.64088251
33MP0000534_abnormal_ureter_morphology1.63350122
34MP0003566_abnormal_cell_adhesion1.62668077
35MP0005409_darkened_coat_color1.58407217
36MP0008932_abnormal_embryonic_tissue1.56413661
37MP0003115_abnormal_respiratory_system1.53331355
38MP0002249_abnormal_larynx_morphology1.52627047
39MP0001849_ear_inflammation1.50792207
40MP0000477_abnormal_intestine_morphology1.46232227
41MP0003329_amyloid_beta_deposits1.45920621
42MP0003119_abnormal_digestive_system1.44615104
43MP0004043_abnormal_pH_regulation1.43129695
44MP0000350_abnormal_cell_proliferation1.42747808
45MP0001346_abnormal_lacrimal_gland1.41417279
46MP0001730_embryonic_growth_arrest1.39840226
47MP0002697_abnormal_eye_size1.38465624
48MP0003941_abnormal_skin_development1.34418956
49MP0003984_embryonic_growth_retardation1.34109305
50MP0002086_abnormal_extraembryonic_tissu1.33393839
51MP0001293_anophthalmia1.32792259
52MP0000569_abnormal_digit_pigmentation1.32566570
53MP0002896_abnormal_bone_mineralization1.31596793
54MP0004272_abnormal_basement_membrane1.30867196
55MP0002088_abnormal_embryonic_growth/wei1.30840278
56MP0005380_embryogenesis_phenotype1.30049577
57MP0001672_abnormal_embryogenesis/_devel1.30049577
58MP0002084_abnormal_developmental_patter1.27677428
59MP0002085_abnormal_embryonic_tissue1.26496769
60MP0005023_abnormal_wound_healing1.25671090
61MP0003183_abnormal_peptide_metabolism1.25248434
62MP0003861_abnormal_nervous_system1.24556613
63MP0001958_emphysema1.24284354
64MP0001188_hyperpigmentation1.22556012
65MP0005381_digestive/alimentary_phenotyp1.20157209
66MP0001663_abnormal_digestive_system1.19933216
67MP0000049_abnormal_middle_ear1.19429548
68MP0002092_abnormal_eye_morphology1.18408213
69MP0002734_abnormal_mechanical_nocicepti1.17840146
70MP0003942_abnormal_urinary_system1.16866501
71MP0002234_abnormal_pharynx_morphology1.16544082
72MP0003123_paternal_imprinting1.16060849
73MP0001697_abnormal_embryo_size1.15411967
74MP0002116_abnormal_craniofacial_bone1.14395500
75MP0002282_abnormal_trachea_morphology1.14280259
76MP0010094_abnormal_chromosome_stability1.13982794
77MP0002909_abnormal_adrenal_gland1.13879641
78MP0002111_abnormal_tail_morphology1.12426221
79MP0003453_abnormal_keratinocyte_physiol1.11513718
80MP0000467_abnormal_esophagus_morphology1.11472914
81MP0000428_abnormal_craniofacial_morphol1.10321978
82MP0003191_abnormal_cellular_cholesterol1.10301643
83MP0002822_catalepsy1.09548419
84MP0001502_abnormal_circadian_rhythm1.09478191
85MP0000955_abnormal_spinal_cord1.08655242
86MP0003937_abnormal_limbs/digits/tail_de1.08449511
87MP0000579_abnormal_nail_morphology1.08168434
88MP0005248_abnormal_Harderian_gland1.07555145
89MP0002877_abnormal_melanocyte_morpholog1.07512181
90MP0004885_abnormal_endolymph1.06731357
91MP0010155_abnormal_intestine_physiology1.06612153
92MP0000678_abnormal_parathyroid_gland1.05739602
93MP0001915_intracranial_hemorrhage1.05448428
94MP0003091_abnormal_cell_migration1.04958983
95MP0004782_abnormal_surfactant_physiolog1.03639408
96MP0001664_abnormal_digestion1.03166569
97MP0003634_abnormal_glial_cell1.03052257
98MP0005503_abnormal_tendon_morphology0.98743589
99MP0002152_abnormal_brain_morphology0.97392347
100MP0003300_gastrointestinal_ulcer0.97235672
101MP0005423_abnormal_somatic_nervous0.97196545
102MP0003938_abnormal_ear_development0.95184161
103MP0004197_abnormal_fetal_growth/weight/0.94813062
104MP0002932_abnormal_joint_morphology0.94687524
105MP0005187_abnormal_penis_morphology0.94478918
106MP0001485_abnormal_pinna_reflex0.91849517
107MP0003635_abnormal_synaptic_transmissio0.91697779
108MP0000026_abnormal_inner_ear0.91233310
109MP0003935_abnormal_craniofacial_develop0.88859396
110MP0002925_abnormal_cardiovascular_devel0.88783036
111MP0003385_abnormal_body_wall0.88371432
112MP0003122_maternal_imprinting0.88261903
113MP0004883_abnormal_blood_vessel0.88260778
114MP0002080_prenatal_lethality0.87114135
115MP0008438_abnormal_cutaneous_collagen0.86402919
116MP0002735_abnormal_chemical_nociception0.86344587
117MP0010678_abnormal_skin_adnexa0.85664895
118MP0003315_abnormal_perineum_morphology0.85264855
119MP0003890_abnormal_embryonic-extraembry0.85169023
120MP0000470_abnormal_stomach_morphology0.84551351
121MP0003121_genomic_imprinting0.82922071
122MP0000762_abnormal_tongue_morphology0.82844009
123MP0005508_abnormal_skeleton_morphology0.82621813
124MP0002063_abnormal_learning/memory/cond0.82475216
125MP0002396_abnormal_hematopoietic_system0.82106096
126MP0009250_abnormal_appendicular_skeleto0.82089650
127MP0010307_abnormal_tumor_latency0.81442954
128MP0009384_cardiac_valve_regurgitation0.81399003
129MP0002882_abnormal_neuron_morphology0.80367595
130MP0004133_heterotaxia0.80188482
131MP0003866_abnormal_defecation0.79934159
132MP0002557_abnormal_social/conspecific_i0.79748068
133MP0001286_abnormal_eye_development0.78410361
134MP0002751_abnormal_autonomic_nervous0.78218053
135MP0004134_abnormal_chest_morphology0.78105013
136MP0000631_abnormal_neuroendocrine_gland0.77935155
137MP0001984_abnormal_olfaction0.76827479
138MP0000613_abnormal_salivary_gland0.76691153
139MP0000432_abnormal_head_morphology0.76632997
140MP0002081_perinatal_lethality0.75947960
141MP0002009_preneoplasia0.75831300
142MP0002184_abnormal_innervation0.74395462
143MP0002098_abnormal_vibrissa_morphology0.73725046
144MP0000733_abnormal_muscle_development0.72725037
145MP0003755_abnormal_palate_morphology0.70617324
146MP0003172_abnormal_lysosome_physiology0.70380325
147MP0001299_abnormal_eye_distance/0.70157356
148MP0006082_CNS_inflammation0.70114827
149MP0005167_abnormal_blood-brain_barrier0.68204385
150MP0002233_abnormal_nose_morphology0.67951029

Predicted human phenotypes

RankGene SetZ-score
1Partial duplication of thumb phalanx (HP:0009944)5.24286982
2Partial duplication of the phalanx of hand (HP:0009999)4.79955871
3Neonatal short-limb short stature (HP:0008921)4.36910802
4Arterial tortuosity (HP:0005116)4.28025615
5Aortic aneurysm (HP:0004942)3.83188720
6Vascular tortuosity (HP:0004948)3.72353792
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.70917334
8Hereditary nonpolyposis colorectal carcinoma (HP:0006716)3.45806113
9Hyperactive renin-angiotensin system (HP:0000841)3.42816448
10Cerebral aneurysm (HP:0004944)3.26675837
11Duplication of thumb phalanx (HP:0009942)3.26196357
12Gastrointestinal carcinoma (HP:0002672)3.21766136
13Malignant gastrointestinal tract tumors (HP:0006749)3.21766136
14Coronal craniosynostosis (HP:0004440)3.08590984
15Chronic bronchitis (HP:0004469)2.95096437
16Aplasia cutis congenita (HP:0001057)2.92544427
17Flat acetabular roof (HP:0003180)2.91830002
18Uterine leiomyosarcoma (HP:0002891)2.88314335
19Leiomyosarcoma (HP:0100243)2.88314335
20Abnormal respiratory motile cilium physiology (HP:0012261)2.86456544
21Urethral obstruction (HP:0000796)2.80135361
22Rhinitis (HP:0012384)2.76990959
23Aortic dissection (HP:0002647)2.75065598
24Glomerulonephritis (HP:0000099)2.74484903
25Uterine neoplasm (HP:0010784)2.74274741
26Abnormal respiratory motile cilium morphology (HP:0005938)2.72760149
27Abnormal respiratory epithelium morphology (HP:0012253)2.72760149
28Bronchomalacia (HP:0002780)2.68035516
29Broad metatarsal (HP:0001783)2.67806887
30Intestinal atresia (HP:0011100)2.64958592
31Deviation of the thumb (HP:0009603)2.64026023
32Esophageal atresia (HP:0002032)2.62863388
33Abnormal ciliary motility (HP:0012262)2.61487077
34Bicuspid aortic valve (HP:0001647)2.58827179
35Hyperacusis (HP:0010780)2.58167768
36Preaxial foot polydactyly (HP:0001841)2.57866555
37Abnormality of the middle phalanges of the toes (HP:0010183)2.56629497
38Vertebral clefting (HP:0008428)2.54884692
39Agnosia (HP:0010524)2.54489599
40Gastrointestinal atresia (HP:0002589)2.53705491
41Arnold-Chiari malformation (HP:0002308)2.52275251
42Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.51318971
43Germ cell neoplasia (HP:0100728)2.50936271
44Biliary tract neoplasm (HP:0100574)2.50031008
45Vertebral hypoplasia (HP:0008417)2.48235208
46Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.48235208
47Proximal placement of thumb (HP:0009623)2.47118302
48Xerostomia (HP:0000217)2.46724599
49Increased nuchal translucency (HP:0010880)2.46375131
50Absent/shortened dynein arms (HP:0200106)2.39262496
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.39262496
52Missing ribs (HP:0000921)2.38364825
53Transitional cell carcinoma of the bladder (HP:0006740)2.35760775
54Abnormality of the right ventricle (HP:0001707)2.35195132
55Alacrima (HP:0000522)2.33222775
56Absent radius (HP:0003974)2.33073274
57Turricephaly (HP:0000262)2.31911910
58Abnormality of the antihelix (HP:0009738)2.31090496
59Spinal cord compression (HP:0002176)2.29665633
60Aplasia involving bones of the upper limbs (HP:0009823)2.28911964
61Aplasia of the phalanges of the hand (HP:0009802)2.28911964
62Aplasia involving bones of the extremities (HP:0009825)2.28911964
63Absent forearm bone (HP:0003953)2.28395243
64Aplasia involving forearm bones (HP:0009822)2.28395243
65Flattened epiphyses (HP:0003071)2.27277115
66Abnormality of the salivary glands (HP:0010286)2.25783218
67High anterior hairline (HP:0009890)2.22998026
68Abnormality of the phalanges of the hallux (HP:0010057)2.22770040
69Short middle phalanx of finger (HP:0005819)2.16968712
70Systemic lupus erythematosus (HP:0002725)2.15525835
71Bladder carcinoma (HP:0002862)2.14337923
72Bladder neoplasm (HP:0009725)2.14337923
73Short nail (HP:0001799)2.13791598
74Neurofibrillary tangles (HP:0002185)2.13741462
75Hyperaldosteronism (HP:0000859)2.13510886
76Rectal fistula (HP:0100590)2.11517539
77Rectovaginal fistula (HP:0000143)2.11517539
78Right ventricular cardiomyopathy (HP:0011663)2.11244879
79Camptodactyly of toe (HP:0001836)2.09297448
80Heterotopia (HP:0002282)2.09206114
81Abnormality of renin-angiotensin system (HP:0000847)2.08575308
82Overriding aorta (HP:0002623)2.06654219
83Thickened helices (HP:0000391)2.06599961
84Spondylolisthesis (HP:0003302)2.06251686
85Abnormality of the diencephalon (HP:0010662)2.06088172
86Bifid scrotum (HP:0000048)2.05253554
87Orthostatic hypotension (HP:0001278)2.04018094
88Visceral angiomatosis (HP:0100761)2.02819604
89Striae distensae (HP:0001065)2.01584372
90Rectal prolapse (HP:0002035)2.01420992
91Broad toe (HP:0001837)2.01004806
92Abnormality of dentin (HP:0010299)1.98006330
93Broad face (HP:0000283)1.96128533
94Premature rupture of membranes (HP:0001788)1.95778173
95Limited elbow extension (HP:0001377)1.95442279
96Broad hallux (HP:0010055)1.95373083
97Deviation of the hallux (HP:0010051)1.94858066
98Skull defect (HP:0001362)1.94839415
99Anal stenosis (HP:0002025)1.94040272
100Cortical dysplasia (HP:0002539)1.93110662
101Intestinal fistula (HP:0100819)1.92367106
102Hallux valgus (HP:0001822)1.92032064
103Ulnar bowing (HP:0003031)1.91527205
104Hemangiomatosis (HP:0007461)1.91365361
105Insomnia (HP:0100785)1.90640953
106Vaginal fistula (HP:0004320)1.90582061
107Aneurysm (HP:0002617)1.89739089
108Decreased circulating renin level (HP:0003351)1.89516515
109Megalencephaly (HP:0001355)1.88711127
110Synostosis of carpal bones (HP:0005048)1.87554207
111Mitral valve prolapse (HP:0001634)1.87438935
112Atrophic scars (HP:0001075)1.86947030
113Vertebral arch anomaly (HP:0008438)1.85900387
114Cerebral inclusion bodies (HP:0100314)1.85491976
115Elfin facies (HP:0004428)1.85122434
116Abnormal vertebral ossification (HP:0100569)1.84044444
117Abnormality of the musculature of the hand (HP:0001421)1.84008831
11811 pairs of ribs (HP:0000878)1.83725801
119Adactyly (HP:0009776)1.83226443
120Neonatal death (HP:0003811)1.82510086
121Renal duplication (HP:0000075)1.81169303
122Renovascular hypertension (HP:0100817)1.80946947
123Synostosis involving bones of the lower limbs (HP:0009138)1.79527361
124Synostosis involving bones of the feet (HP:0009140)1.79527361
125Ependymoma (HP:0002888)1.79366075
126Shallow orbits (HP:0000586)1.78384703
127Abnormality of the costochondral junction (HP:0000919)1.78294965
128Abnormality of the duodenum (HP:0002246)1.78182985
129Abnormal ossification of hand bones (HP:0005921)1.77651726
130Abnormality of carpal bone ossification (HP:0006257)1.77343831
131Protrusio acetabuli (HP:0003179)1.76630379
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.76571706
133Hematochezia (HP:0002573)1.75966224
134Micronodular cirrhosis (HP:0001413)1.74851375
135Recurrent corneal erosions (HP:0000495)1.74777455
136Abnormally folded helix (HP:0008544)1.74064216
137Cutaneous finger syndactyly (HP:0010554)1.73870631
138Decreased lacrimation (HP:0000633)1.73809056
139Renal cell carcinoma (HP:0005584)1.73634583
140Overfolded helix (HP:0000396)1.72668100
141Small intestinal stenosis (HP:0012848)1.71664334
142Duodenal stenosis (HP:0100867)1.71664334
143Tibial bowing (HP:0002982)1.69458842
144Obstructive sleep apnea (HP:0002870)1.68377985
145Carpal synostosis (HP:0009702)1.68319807
146Hyperparathyroidism (HP:0000843)1.67994097
147Abnormality of the distal phalanges of the toes (HP:0010182)1.67834281
148Cutaneous syndactyly (HP:0012725)1.65843929
149Metabolic alkalosis (HP:0200114)1.64698257
150Midface retrusion (HP:0011800)1.62631796
151Abnormality of the dental root (HP:0006486)1.62545346
152Taurodontia (HP:0000679)1.62545346
153Abnormality of permanent molar morphology (HP:0011071)1.62545346
154Bladder diverticulum (HP:0000015)1.61692242
155Abnormal hand bone ossification (HP:0010660)1.60164311
156Infertility (HP:0000789)1.57980609
157Myokymia (HP:0002411)1.56742035
158Bronchiectasis (HP:0002110)1.54622679
159Omphalocele (HP:0001539)1.54178411
160Male infertility (HP:0003251)1.53413207
161Abnormality of molar morphology (HP:0011070)1.52676886
162Abnormality of molar (HP:0011077)1.52676886
163Abnormality of chloride homeostasis (HP:0011422)1.52197925
164Hyperextensible skin (HP:0000974)1.49315195
165Hypercalciuria (HP:0002150)1.47200742
166Abnormality of the 4th metacarpal (HP:0010012)1.47174736
167Tracheomalacia (HP:0002779)1.47041100
168Abnormal tarsal ossification (HP:0008369)1.45299254
169Congenital glaucoma (HP:0001087)1.44569555
170Tracheal stenosis (HP:0002777)1.44260507
171Choanal stenosis (HP:0000452)1.43666072
172Renal salt wasting (HP:0000127)1.42104643
173Hypercalcemia (HP:0003072)1.41967247
174Septo-optic dysplasia (HP:0100842)1.41843357
175Large earlobe (HP:0009748)1.40017947
176Intrahepatic cholestasis (HP:0001406)1.36373257
177Overgrowth (HP:0001548)1.35357357

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.66015346
2TGFBR24.29222902
3EPHA23.63425256
4PAK43.51449694
5CASK2.94863632
6NTRK12.88387038
7PNCK2.72672665
8EEF2K2.55071394
9EPHB22.51251313
10FGFR32.46886056
11CDK122.44132631
12MAP3K102.37051087
13STK102.22873620
14MARK12.12287511
15LATS22.12283033
16FGFR12.03846535
17CDK81.98678377
18MELK1.90601337
19PRKD31.83232608
20TTK1.83049088
21CAMK1G1.78281847
22PTK61.70558786
23TSSK61.63400444
24NEK21.61025632
25PKN21.59119546
26BCR1.58875160
27LMTK21.50179012
28RPS6KB21.44899493
29PDGFRA1.44151257
30CAMK1D1.43950702
31STK391.36894301
32MST41.36380183
33NEK11.35140513
34KSR11.34062581
35MAP3K81.30196253
36TGFBR11.26994977
37NTRK21.24754085
38MAP2K21.24694185
39MATK1.21711914
40CDC71.20883857
41PAK21.11469482
42EPHA41.11382499
43AURKB1.08857468
44NTRK31.08837306
45ERBB21.08420190
46TNIK1.07211086
47PRKG21.07065120
48TRIB31.05890985
49PASK1.05492344
50SMG11.03827488
51STK38L1.03230940
52MAPK150.98474051
53CSF1R0.97537186
54LIMK10.96350925
55CDK90.95314954
56LATS10.94133657
57CDK60.93985766
58DDR20.93330357
59CDK70.91800581
60BRD40.91766503
61TESK10.91668567
62PLK10.91643039
63ICK0.90590636
64DYRK30.89650048
65RPS6KA40.86647594
66FRK0.85263071
67NUAK10.84192453
68TLK10.84033134
69SCYL20.83840064
70CDK40.80994095
71PDGFRB0.80616835
72NEK90.77807600
73ERN10.77645624
74MINK10.77009431
75TYRO30.76824957
76MAPKAPK30.74526403
77TYK20.74111094
78UHMK10.73804638
79MST1R0.71143705
80LRRK20.70555225
81PIK3CA0.69380389
82SIK10.69191833
83STK380.68050822
84PTK20.67825490
85ATR0.66384540
86MAP3K90.65506982
87AKT20.65109640
88FER0.64570189
89MTOR0.64411149
90BRSK10.64233972
91FGFR20.63907771
92VRK10.63143625
93SGK4940.62958045
94SGK2230.62958045
95RIPK10.62324233
96CHUK0.62270825
97DMPK0.62261910
98AKT30.62174890
99STK30.61951547
100EPHB10.60940655
101CDK180.58661040
102CDK150.58172294
103SIK30.56873673
104NEK60.54756159
105MOS0.54631442
106CDK11A0.54466816
107ITK0.53887769
108STK240.52674643
109CHEK10.52309122
110PHKG20.52102428
111PHKG10.52102428
112PAK60.52016103
113MARK20.51866366
114ARAF0.50217359
115PAK10.50049102
116CDK140.49942073
117PLK30.49408881
118PBK0.49339327
119GRK70.49328180
120GRK60.48620455
121MET0.48618413
122MKNK20.48203331
123SIK20.47832085
124ERBB30.47723087
125CSNK1E0.47448291
126PDK20.47006607
127CDK50.46860675
128IGF1R0.46731541
129ILK0.46295027
130SGK30.46245341
131CAMK2G0.45846817
132DYRK20.45749746
133CAMK2B0.44374811
134ACVR1B0.43750056
135MAP2K10.42995479
136CAMK2D0.42314055
137STK40.42182807
138EPHA30.41932935
139PRKCI0.41782438
140MAPKAPK20.41010584
141TTN0.40077147
142MAPK100.39138843
143ROCK10.38508857
144CHEK20.38078823
145WNK40.36942111
146CSK0.36865842
147AURKA0.36780622
148ERBB40.36314887
149RPS6KA20.36183736
150YES10.36152334
151ROCK20.35638126
152WEE10.35368405
153ALK0.35158579
154MAP2K70.33227992
155BRAF0.32560033
156MKNK10.31475814

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.81172482
2Notch signaling pathway_Homo sapiens_hsa043302.56778275
3Basal cell carcinoma_Homo sapiens_hsa052172.52084831
4Adherens junction_Homo sapiens_hsa045202.15031900
5DNA replication_Homo sapiens_hsa030302.05645336
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.00991951
7Hippo signaling pathway_Homo sapiens_hsa043902.00368002
8Cell cycle_Homo sapiens_hsa041101.96373367
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95891801
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90008022
11Spliceosome_Homo sapiens_hsa030401.88533634
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.88183438
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.86588532
14Hedgehog signaling pathway_Homo sapiens_hsa043401.82067970
15Bladder cancer_Homo sapiens_hsa052191.80283836
16Colorectal cancer_Homo sapiens_hsa052101.79172524
17Histidine metabolism_Homo sapiens_hsa003401.76238552
18MicroRNAs in cancer_Homo sapiens_hsa052061.72316138
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.70865811
20Chronic myeloid leukemia_Homo sapiens_hsa052201.70647213
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.63295602
22Bile secretion_Homo sapiens_hsa049761.62842151
23Mismatch repair_Homo sapiens_hsa034301.53281032
24RNA transport_Homo sapiens_hsa030131.53075434
25Base excision repair_Homo sapiens_hsa034101.49599782
26Thyroid hormone synthesis_Homo sapiens_hsa049181.49442756
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45953977
28Other glycan degradation_Homo sapiens_hsa005111.45561404
29Small cell lung cancer_Homo sapiens_hsa052221.43485875
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43443237
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.42187397
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.41108022
33Proteoglycans in cancer_Homo sapiens_hsa052051.38685296
34Pancreatic cancer_Homo sapiens_hsa052121.35661367
35Arginine and proline metabolism_Homo sapiens_hsa003301.28236566
36Mineral absorption_Homo sapiens_hsa049781.27649671
37TGF-beta signaling pathway_Homo sapiens_hsa043501.27577309
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26450316
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26203114
40Tight junction_Homo sapiens_hsa045301.26163951
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26142892
42p53 signaling pathway_Homo sapiens_hsa041151.25821555
43Protein digestion and absorption_Homo sapiens_hsa049741.25633722
44Cocaine addiction_Homo sapiens_hsa050301.21223117
45Arginine biosynthesis_Homo sapiens_hsa002201.20657789
46mRNA surveillance pathway_Homo sapiens_hsa030151.19498158
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17638772
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16338359
49HTLV-I infection_Homo sapiens_hsa051661.16008074
50Thyroid cancer_Homo sapiens_hsa052161.15693989
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12905621
52Pancreatic secretion_Homo sapiens_hsa049721.11327161
53Antigen processing and presentation_Homo sapiens_hsa046121.09153817
54Pathways in cancer_Homo sapiens_hsa052001.08713126
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08584163
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.07092273
57Apoptosis_Homo sapiens_hsa042101.07086773
58Gap junction_Homo sapiens_hsa045401.06912158
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06110860
60Shigellosis_Homo sapiens_hsa051311.05530164
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05508849
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05376228
63N-Glycan biosynthesis_Homo sapiens_hsa005101.04374359
64Prion diseases_Homo sapiens_hsa050201.03739056
65Toxoplasmosis_Homo sapiens_hsa051451.02558744
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01461452
67Viral carcinogenesis_Homo sapiens_hsa052031.01448223
68Sulfur metabolism_Homo sapiens_hsa009201.01094326
69Phenylalanine metabolism_Homo sapiens_hsa003601.00652657
70Vibrio cholerae infection_Homo sapiens_hsa051100.99192009
71Focal adhesion_Homo sapiens_hsa045100.99000378
72Vitamin B6 metabolism_Homo sapiens_hsa007500.98727489
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98414124
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98334357
75Legionellosis_Homo sapiens_hsa051340.96993707
76Gastric acid secretion_Homo sapiens_hsa049710.95397328
77Viral myocarditis_Homo sapiens_hsa054160.94362799
78Insulin secretion_Homo sapiens_hsa049110.93913191
79beta-Alanine metabolism_Homo sapiens_hsa004100.93883736
80Wnt signaling pathway_Homo sapiens_hsa043100.93724265
81Nicotine addiction_Homo sapiens_hsa050330.93285757
82Estrogen signaling pathway_Homo sapiens_hsa049150.91885765
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91800993
84Endometrial cancer_Homo sapiens_hsa052130.91191899
85Systemic lupus erythematosus_Homo sapiens_hsa053220.89389497
86Dorso-ventral axis formation_Homo sapiens_hsa043200.88529872
87Leishmaniasis_Homo sapiens_hsa051400.88080577
88Pertussis_Homo sapiens_hsa051330.87884840
89ECM-receptor interaction_Homo sapiens_hsa045120.87841731
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87398467
91Amphetamine addiction_Homo sapiens_hsa050310.87316045
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87166845
93Non-homologous end-joining_Homo sapiens_hsa034500.87105442
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82992780
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82728482
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81885094
97Rap1 signaling pathway_Homo sapiens_hsa040150.81609048
98Dopaminergic synapse_Homo sapiens_hsa047280.80191873
99Osteoclast differentiation_Homo sapiens_hsa043800.79574307
100Nitrogen metabolism_Homo sapiens_hsa009100.79513642
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77748119
102Biosynthesis of amino acids_Homo sapiens_hsa012300.77200993
103ErbB signaling pathway_Homo sapiens_hsa040120.76782136
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76533232
105Hepatitis B_Homo sapiens_hsa051610.73917105
106Glutamatergic synapse_Homo sapiens_hsa047240.73807826
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71956923
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71611628
109Fanconi anemia pathway_Homo sapiens_hsa034600.71350999
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70466948
111Salmonella infection_Homo sapiens_hsa051320.68740083
112Fatty acid metabolism_Homo sapiens_hsa012120.68390966
113Prostate cancer_Homo sapiens_hsa052150.68087341
114Fatty acid biosynthesis_Homo sapiens_hsa000610.66623224
115Endocytosis_Homo sapiens_hsa041440.66317687
116Influenza A_Homo sapiens_hsa051640.66009093
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65894952
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65797080
119Pyruvate metabolism_Homo sapiens_hsa006200.65599747
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64739401
121Renal cell carcinoma_Homo sapiens_hsa052110.64406540
122Nucleotide excision repair_Homo sapiens_hsa034200.64061350
123HIF-1 signaling pathway_Homo sapiens_hsa040660.63798305
124VEGF signaling pathway_Homo sapiens_hsa043700.63194617
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62760037
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62593022
127Lysine degradation_Homo sapiens_hsa003100.61851073
128Circadian entrainment_Homo sapiens_hsa047130.61585606
129Platelet activation_Homo sapiens_hsa046110.61413903
130Tyrosine metabolism_Homo sapiens_hsa003500.61409812
131AMPK signaling pathway_Homo sapiens_hsa041520.61276756
132Sphingolipid metabolism_Homo sapiens_hsa006000.60838609
133Lysosome_Homo sapiens_hsa041420.60262670
134Non-small cell lung cancer_Homo sapiens_hsa052230.59517234
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.59449965
136Dilated cardiomyopathy_Homo sapiens_hsa054140.59155217
137Fat digestion and absorption_Homo sapiens_hsa049750.58927292
138mTOR signaling pathway_Homo sapiens_hsa041500.58431820
139Choline metabolism in cancer_Homo sapiens_hsa052310.58281803
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58275120
141Long-term potentiation_Homo sapiens_hsa047200.57487678
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57431799
143Synaptic vesicle cycle_Homo sapiens_hsa047210.57029952
144Fatty acid degradation_Homo sapiens_hsa000710.56847946
145Epstein-Barr virus infection_Homo sapiens_hsa051690.56679385
146Salivary secretion_Homo sapiens_hsa049700.56079732
147Renin-angiotensin system_Homo sapiens_hsa046140.56065864
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55947779
149Hematopoietic cell lineage_Homo sapiens_hsa046400.55888275
150Retinol metabolism_Homo sapiens_hsa008300.55739373
151Cholinergic synapse_Homo sapiens_hsa047250.55596664
152Melanogenesis_Homo sapiens_hsa049160.55357649
153Oocyte meiosis_Homo sapiens_hsa041140.55078575
154cAMP signaling pathway_Homo sapiens_hsa040240.54149198
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51965882
156Herpes simplex infection_Homo sapiens_hsa051680.50374442
157TNF signaling pathway_Homo sapiens_hsa046680.50117466
158PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49288877
159Glioma_Homo sapiens_hsa052140.48811144
160NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48294077
161Amoebiasis_Homo sapiens_hsa051460.46468524
162Axon guidance_Homo sapiens_hsa043600.46242442
163Staphylococcus aureus infection_Homo sapiens_hsa051500.45529531
164Fructose and mannose metabolism_Homo sapiens_hsa000510.44541802
165Homologous recombination_Homo sapiens_hsa034400.42073101

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