GOLPH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.19105432
2Golgi transport vesicle coating (GO:0048200)6.19105432
3COPII vesicle coating (GO:0048208)4.71630416
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.48697991
5growth hormone receptor signaling pathway (GO:0060396)4.12238278
6protein retention in ER lumen (GO:0006621)4.04135146
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.99387323
8positive regulation of nuclease activity (GO:0032075)3.85142345
9endoplasmic reticulum unfolded protein response (GO:0030968)3.56118823
10cellular response to growth hormone stimulus (GO:0071378)3.55676330
11regulation of nuclease activity (GO:0032069)3.51227074
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.47519865
13cellular response to unfolded protein (GO:0034620)3.44867989
14ER-nucleus signaling pathway (GO:0006984)3.34418689
15vesicle coating (GO:0006901)3.29714323
16cellular response to topologically incorrect protein (GO:0035967)3.26924794
17UDP-N-acetylglucosamine metabolic process (GO:0006047)3.26074364
18cytoplasmic mRNA processing body assembly (GO:0033962)3.24778855
19type B pancreatic cell development (GO:0003323)3.21802200
20positive regulation of p38MAPK cascade (GO:1900745)3.21434553
214-hydroxyproline metabolic process (GO:0019471)3.20775914
22negative regulation of fatty acid transport (GO:2000192)3.17531954
23regulation of glucose import in response to insulin stimulus (GO:2001273)3.13086305
24exocrine pancreas development (GO:0031017)3.10814303
25basement membrane organization (GO:0071711)3.10242847
26response to laminar fluid shear stress (GO:0034616)2.99552317
27urea cycle (GO:0000050)2.97640085
28pinocytosis (GO:0006907)2.95340784
29L-alpha-amino acid transmembrane transport (GO:1902475)2.95068105
30intestinal absorption (GO:0050892)2.91173946
31intestinal epithelial cell development (GO:0060576)2.88198528
32urea metabolic process (GO:0019627)2.86874702
33glandular epithelial cell development (GO:0002068)2.83718849
34response to endoplasmic reticulum stress (GO:0034976)2.83457743
35positive regulation of extracellular matrix organization (GO:1903055)2.82490146
36ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.81095350
37valine metabolic process (GO:0006573)2.78852230
38hormone catabolic process (GO:0042447)2.77497155
39intestinal cholesterol absorption (GO:0030299)2.77115763
40hepatocyte apoptotic process (GO:0097284)2.77056638
41positive regulation of histone deacetylation (GO:0031065)2.75871680
42desmosome organization (GO:0002934)2.75438434
43cellular response to vitamin D (GO:0071305)2.75309279
44positive regulation of hormone biosynthetic process (GO:0046886)2.74984481
45focal adhesion assembly (GO:0048041)2.74210468
46cell-substrate adherens junction assembly (GO:0007045)2.74210468
47definitive hemopoiesis (GO:0060216)2.74171075
48columnar/cuboidal epithelial cell development (GO:0002066)2.73686397
49surfactant homeostasis (GO:0043129)2.72744100
50regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.72264393
51adherens junction assembly (GO:0034333)2.69655073
52JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.69600684
53corticosteroid receptor signaling pathway (GO:0031958)2.69285874
54positive regulation of endothelial cell apoptotic process (GO:2000353)2.67174844
55apoptotic cell clearance (GO:0043277)2.65406481
56pentose-phosphate shunt (GO:0006098)2.63798951
57negative regulation of protein localization to plasma membrane (GO:1903077)2.63477670
58regulation of early endosome to late endosome transport (GO:2000641)2.62500785
59regulation of cholesterol homeostasis (GO:2000188)2.62144291
60positive regulation of glycoprotein metabolic process (GO:1903020)2.61942785
61protein localization to endosome (GO:0036010)2.61455373
62positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.60438529
63positive regulation of fatty acid beta-oxidation (GO:0032000)2.59773540
64regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.59604954
65epithelial cell-cell adhesion (GO:0090136)2.58620657
66response to unfolded protein (GO:0006986)2.57615857
67negative regulation of erythrocyte differentiation (GO:0045647)2.57499204
68cell adhesion mediated by integrin (GO:0033627)2.57005210
69regulation of protein activation cascade (GO:2000257)2.56730432
70glucocorticoid receptor signaling pathway (GO:0042921)2.55606577
71negative regulation of lipid transport (GO:0032369)2.55507085
72maternal placenta development (GO:0001893)2.54500104
73nitrogen cycle metabolic process (GO:0071941)2.54101014
74trophectodermal cell differentiation (GO:0001829)2.53919139
75sequestering of metal ion (GO:0051238)2.52924846
76regulation of complement activation (GO:0030449)2.52770933
77response to topologically incorrect protein (GO:0035966)2.48723204
78proline biosynthetic process (GO:0006561)2.48228410
79hemidesmosome assembly (GO:0031581)2.48159707
80endocrine pancreas development (GO:0031018)2.47677064
81hypotonic response (GO:0006971)2.46035313
82cellular protein complex localization (GO:0034629)2.45588546
83* Golgi organization (GO:0007030)2.44542855
84regulation of fatty acid beta-oxidation (GO:0031998)2.44454263
85sulfur amino acid catabolic process (GO:0000098)2.42890892
86regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.41971384
87histone H2A monoubiquitination (GO:0035518)2.41545077
88regulation of RNA export from nucleus (GO:0046831)2.41313525
89macroautophagy (GO:0016236)2.41090972
90lysine catabolic process (GO:0006554)2.40703360
91lysine metabolic process (GO:0006553)2.40703360
92regulation of membrane protein ectodomain proteolysis (GO:0051043)2.40152274
93regulation of transforming growth factor beta2 production (GO:0032909)2.39179856
94antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.38616981
95antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.38616981
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.38170644
97regulation of glucocorticoid metabolic process (GO:0031943)2.36980926
98positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.36763353
993-UTR-mediated mRNA stabilization (GO:0070935)2.36577643
100stress fiber assembly (GO:0043149)2.36238960
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35602372
102cysteine metabolic process (GO:0006534)2.35556647
103cellular response to vitamin (GO:0071295)2.34829173
104nuclear pore organization (GO:0006999)2.34461470
105regulation of nucleobase-containing compound transport (GO:0032239)2.33256625
106negative regulation of protein activation cascade (GO:2000258)2.32760349
107peptidyl-glutamic acid carboxylation (GO:0017187)2.32503140
108protein carboxylation (GO:0018214)2.32503140
109NADPH regeneration (GO:0006740)2.31816514
110cell-substrate junction assembly (GO:0007044)2.31212103
111transcytosis (GO:0045056)2.30851145
112mRNA stabilization (GO:0048255)2.30418344
113RNA stabilization (GO:0043489)2.30418344
114alpha-linolenic acid metabolic process (GO:0036109)2.29747645
115low-density lipoprotein particle clearance (GO:0034383)2.29626928
116tricarboxylic acid metabolic process (GO:0072350)2.28810402
117regulation of mammary gland epithelial cell proliferation (GO:0033599)2.28746059
118peptidyl-proline hydroxylation (GO:0019511)2.28626979
119embryonic process involved in female pregnancy (GO:0060136)2.28044976
120endothelium development (GO:0003158)2.26536325
121gland morphogenesis (GO:0022612)2.26148732
122DNA unwinding involved in DNA replication (GO:0006268)2.25151608
123planar cell polarity pathway involved in neural tube closure (GO:0090179)2.24957117
124purine ribonucleotide transport (GO:0015868)2.24902147
125keratan sulfate catabolic process (GO:0042340)2.24817391
126protein complex localization (GO:0031503)2.24600702
127negative regulation of fibrinolysis (GO:0051918)2.22624106
128regulation of hippo signaling (GO:0035330)2.21002810
129complement activation, alternative pathway (GO:0006957)2.18962490
130regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.18056344
131regulation of transforming growth factor beta1 production (GO:0032908)2.18032547
132mitotic chromosome condensation (GO:0007076)2.17618432
133membrane raft organization (GO:0031579)2.17468044
134protein hydroxylation (GO:0018126)2.17325044
135folic acid-containing compound biosynthetic process (GO:0009396)2.17251612
136hyaluronan catabolic process (GO:0030214)2.16750349
137embryonic foregut morphogenesis (GO:0048617)2.16731259
138regulation of transforming growth factor beta production (GO:0071634)2.15569216
139response to growth hormone (GO:0060416)2.15560175
140ER to Golgi vesicle-mediated transport (GO:0006888)2.15445270
141ER overload response (GO:0006983)2.14879292
142regulation of steroid hormone biosynthetic process (GO:0090030)2.14627070
143negative regulation of complement activation (GO:0045916)2.14585427
144negative regulation of fatty acid biosynthetic process (GO:0045717)2.14479571
145membrane protein ectodomain proteolysis (GO:0006509)2.14262792
146cellular hyperosmotic response (GO:0071474)2.13718476
147response to thyroid hormone (GO:0097066)2.13386473
148positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.13276816
149positive regulation of keratinocyte differentiation (GO:0045618)2.12321104
150regulation of metalloenzyme activity (GO:0048552)2.12081808
151epithelial cell differentiation involved in prostate gland development (GO:0060742)2.12061889
152branching involved in mammary gland duct morphogenesis (GO:0060444)2.10988797
153regulation of extracellular matrix organization (GO:1903053)2.10889736
154purine nucleotide transport (GO:0015865)2.10840830
155positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.10274309
156positive regulation of glycogen biosynthetic process (GO:0045725)2.09855730
157homocysteine metabolic process (GO:0050667)2.09659638
158iron ion import (GO:0097286)2.09536732
159nuclear pore complex assembly (GO:0051292)2.09167693
160skin morphogenesis (GO:0043589)2.08607555
161regulation of histone H3-K27 methylation (GO:0061085)2.08521188
162positive regulation of glycolytic process (GO:0045821)2.08455238
163intracellular lipid transport (GO:0032365)2.08307434
164bundle of His cell to Purkinje myocyte communication (GO:0086069)2.08071156
165protein autoprocessing (GO:0016540)2.07968674
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.07393019
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.06554902
168monoubiquitinated protein deubiquitination (GO:0035520)2.05889035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.31047301
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.58803059
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.50178306
4E2F7_22180533_ChIP-Seq_HELA_Human3.45460409
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.43727959
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.25981004
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.22781996
8CLOCK_20551151_ChIP-Seq_293T_Human3.02466368
9GATA1_22025678_ChIP-Seq_K562_Human2.75279609
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.68300998
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.47904858
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.46943013
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31408211
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.12407150
15FOXO3_23340844_ChIP-Seq_DLD1_Human2.12334271
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.01103013
17* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.91389739
18ZNF263_19887448_ChIP-Seq_K562_Human1.89847719
19* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.89573402
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85653702
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84109550
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82302452
23FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.78484010
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.76914936
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76706924
26ATF3_27146783_Chip-Seq_COLON_Human1.68664153
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.67704365
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67588238
29* VDR_21846776_ChIP-Seq_THP-1_Human1.67523124
30* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66405282
31AR_21909140_ChIP-Seq_LNCAP_Human1.65764248
32FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.64668227
33MYC_22102868_ChIP-Seq_BL_Human1.64196394
34ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.64114151
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62575686
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62113287
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60264407
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59762869
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59640056
40* GATA6_25053715_ChIP-Seq_YYC3_Human1.59620118
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.58700358
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58375313
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56768254
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56581127
45* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55440423
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51511221
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51282107
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50263809
49* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49724971
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47881337
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47350837
52GATA4_25053715_ChIP-Seq_YYC3_Human1.47136662
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45435959
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.44518655
55TCF7_22412390_ChIP-Seq_EML_Mouse1.43714776
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43578756
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39799471
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38483920
59BRD4_25478319_ChIP-Seq_HGPS_Human1.38014377
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36620288
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36551121
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33285123
63* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32533285
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31816695
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31321626
66SOX2_20726797_ChIP-Seq_SW620_Human1.31316492
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31045733
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27787166
69CHD1_26751641_Chip-Seq_LNCaP_Human1.26848621
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26480895
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26480895
72UBF1/2_26484160_Chip-Seq_HMECs_Human1.26243825
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24632819
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.24510470
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.23586505
76* VDR_24763502_ChIP-Seq_THP-1_Human1.23470630
77* LXR_22292898_ChIP-Seq_THP-1_Human1.23258191
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23168731
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22226529
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22107468
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.21462938
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21348075
83GATA3_24758297_ChIP-Seq_MCF-7_Human1.20934366
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20270336
85FOXA2_19822575_ChIP-Seq_HepG2_Human1.20087934
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19921465
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19464990
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19431077
89RUNX1_27514584_Chip-Seq_MCF-7_Human1.19172582
90CJUN_26792858_Chip-Seq_BT549_Human1.18022304
91MYB_26560356_Chip-Seq_TH2_Human1.17832850
92TFEB_21752829_ChIP-Seq_HELA_Human1.17637771
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17271609
94RACK7_27058665_Chip-Seq_MCF-7_Human1.16693592
95NCOR1_26117541_ChIP-Seq_K562_Human1.16645492
96* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16463914
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.16255419
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16190513
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15763003
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14772139
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14772139
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14772139
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14121504
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13691786
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12913997
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12385995
107* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12273176
108NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10767657
109* RUNX1_22412390_ChIP-Seq_EML_Mouse1.10315637
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09932956
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08230090
112NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08100835
113PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07497752
114* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07147212
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07027414
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06653676
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06309510
118* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06136407
119MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05444640
120ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05282104
121GATA1_19941826_ChIP-Seq_K562_Human1.05229208
122* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05171191
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04964687
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.04759788
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04403926
126* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03873496
127FOXA1_25552417_ChIP-Seq_VCAP_Human1.03835715
128* GATA3_27048872_Chip-Seq_THYMUS_Human1.03089016
129MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02671644
130SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02102614
131MYB_26560356_Chip-Seq_TH1_Human0.99084213
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98898304
133KDM2B_26808549_Chip-Seq_DND41_Human0.98348038
134SMAD_19615063_ChIP-ChIP_OVARY_Human0.98273819
135MAF_26560356_Chip-Seq_TH1_Human0.97323287
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97059722
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.96509022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.91933642
2MP0010234_abnormal_vibrissa_follicle3.55110764
3MP0003300_gastrointestinal_ulcer3.45931760
4MP0003705_abnormal_hypodermis_morpholog3.25195792
5MP0002139_abnormal_hepatobiliary_system2.76618506
6MP0010352_gastrointestinal_tract_polyps2.57104264
7MP0006054_spinal_hemorrhage2.50920089
8MP0005076_abnormal_cell_differentiation2.32453700
9MP0002138_abnormal_hepatobiliary_system2.32359124
10MP0004264_abnormal_extraembryonic_tissu2.25910627
11MP0005451_abnormal_body_composition2.25069493
12MP0003191_abnormal_cellular_cholesterol2.05234187
13MP0002796_impaired_skin_barrier2.00685329
14MP0003252_abnormal_bile_duct1.92262426
15MP0005365_abnormal_bile_salt1.88671295
16MP0005360_urolithiasis1.80967694
17MP0003566_abnormal_cell_adhesion1.74488125
18MP0001666_abnormal_nutrient_absorption1.72475106
19MP0008438_abnormal_cutaneous_collagen1.67849364
20MP0005220_abnormal_exocrine_pancreas1.61510297
21MP0009384_cardiac_valve_regurgitation1.57294480
22MP0004185_abnormal_adipocyte_glucose1.57123116
23MP0005085_abnormal_gallbladder_physiolo1.50055411
24MP0001849_ear_inflammation1.48928035
25MP0002896_abnormal_bone_mineralization1.48242090
26MP0005623_abnormal_meninges_morphology1.45101349
27MP0004782_abnormal_surfactant_physiolog1.40713012
28MP0005501_abnormal_skin_physiology1.39243867
29MP0001944_abnormal_pancreas_morphology1.38561613
30MP0001881_abnormal_mammary_gland1.38117267
31MP0003195_calcinosis1.36834430
32MP0005275_abnormal_skin_tensile1.36782035
33MP0002166_altered_tumor_susceptibility1.27496279
34MP0002396_abnormal_hematopoietic_system1.27114575
35MP0005023_abnormal_wound_healing1.26446414
36MP0003453_abnormal_keratinocyte_physiol1.26401902
37MP0004808_abnormal_hematopoietic_stem1.23521283
38MP0009278_abnormal_bone_marrow1.22681800
39MP0010307_abnormal_tumor_latency1.22532318
40MP0009780_abnormal_chondrocyte_physiolo1.18259038
41MP0002060_abnormal_skin_morphology1.18210981
42MP0002009_preneoplasia1.15781198
43MP0010368_abnormal_lymphatic_system1.15740635
44MP0002254_reproductive_system_inflammat1.15506788
45MP0003045_fibrosis1.15361537
46MP0002693_abnormal_pancreas_physiology1.14188473
47MP0000609_abnormal_liver_physiology1.12972633
48MP0001730_embryonic_growth_arrest1.12596761
49MP0000013_abnormal_adipose_tissue1.12354398
50MP0004947_skin_inflammation1.11178098
51MP0003303_peritoneal_inflammation1.10597609
52MP0005409_darkened_coat_color1.10218145
53MP0003279_aneurysm1.09540256
54MP0002928_abnormal_bile_duct1.07599729
55MP0005083_abnormal_biliary_tract1.07295464
56MP0002909_abnormal_adrenal_gland1.07234785
57MP0009643_abnormal_urine_homeostasis1.06002477
58MP0000465_gastrointestinal_hemorrhage1.05957696
59MP0003941_abnormal_skin_development1.05811532
60MP0002006_tumorigenesis1.05458523
61MP0003283_abnormal_digestive_organ1.05140084
62MP0002168_other_aberrant_phenotype1.04613453
63MP0010678_abnormal_skin_adnexa1.03824249
64MP0008004_abnormal_stomach_pH1.03675178
65MP0003436_decreased_susceptibility_to1.01349370
66MP0004272_abnormal_basement_membrane1.00895853
67MP0003868_abnormal_feces_composition0.99462566
68MP0005464_abnormal_platelet_physiology0.98965794
69MP0000003_abnormal_adipose_tissue0.98506160
70MP0005248_abnormal_Harderian_gland0.98320358
71MP0001533_abnormal_skeleton_physiology0.96956136
72MP0003091_abnormal_cell_migration0.96945607
73MP0003795_abnormal_bone_structure0.96904390
74MP0008260_abnormal_autophagy0.96281519
75MP0005621_abnormal_cell_physiology0.95778686
76MP0010329_abnormal_lipoprotein_level0.94992195
77MP0000767_abnormal_smooth_muscle0.94556392
78MP0000350_abnormal_cell_proliferation0.93486471
79MP0005666_abnormal_adipose_tissue0.91963980
80MP0004957_abnormal_blastocyst_morpholog0.91911695
81MP0000858_altered_metastatic_potential0.90801742
82MP0005058_abnormal_lysosome_morphology0.90444730
83MP0003828_pulmonary_edema0.90277364
84MP0008961_abnormal_basal_metabolism0.90025288
85MP0003950_abnormal_plasma_membrane0.89222212
86MP0001348_abnormal_lacrimal_gland0.88731541
87MP0003984_embryonic_growth_retardation0.87430669
88MP0005375_adipose_tissue_phenotype0.86414515
89MP0000462_abnormal_digestive_system0.86376738
90MP0000733_abnormal_muscle_development0.86349610
91MP0003183_abnormal_peptide_metabolism0.85248463
92MP0010630_abnormal_cardiac_muscle0.84556522
93MP0001915_intracranial_hemorrhage0.84220678
94MP0005165_increased_susceptibility_to0.83204991
95MP0009840_abnormal_foam_cell0.81974782
96MP0001851_eye_inflammation0.81973430
97MP0009053_abnormal_anal_canal0.81843816
98MP0000627_abnormal_mammary_gland0.81186409
99MP0002086_abnormal_extraembryonic_tissu0.79748187
100MP0005380_embryogenesis_phenotype0.79577943
101MP0001672_abnormal_embryogenesis/_devel0.79577943
102MP0005503_abnormal_tendon_morphology0.78868656
103MP0010155_abnormal_intestine_physiology0.78326660
104MP0000163_abnormal_cartilage_morphology0.77473711
105MP0000537_abnormal_urethra_morphology0.76395292
106MP0001958_emphysema0.75712809
107MP0002998_abnormal_bone_remodeling0.75507382
108MP0008875_abnormal_xenobiotic_pharmacok0.75307741
109MP0000598_abnormal_liver_morphology0.75049358
110MP0002098_abnormal_vibrissa_morphology0.75024291
111MP0003656_abnormal_erythrocyte_physiolo0.74834903
112MP0005408_hypopigmentation0.74681420
113MP0004233_abnormal_muscle_weight0.74654888
114MP0001879_abnormal_lymphatic_vessel0.74610322
115MP0001853_heart_inflammation0.74493532
116MP0002080_prenatal_lethality0.74481392
117MP0001545_abnormal_hematopoietic_system0.74040266
118MP0005397_hematopoietic_system_phenotyp0.74040266
119MP0004858_abnormal_nervous_system0.73571001
120MP0003448_altered_tumor_morphology0.73326091
121MP0003763_abnormal_thymus_physiology0.73108915
122MP0009333_abnormal_splenocyte_physiolog0.73063081
123MP0005508_abnormal_skeleton_morphology0.72976017
124MP0005390_skeleton_phenotype0.72867586
125MP0000377_abnormal_hair_follicle0.72825089
126MP0000613_abnormal_salivary_gland0.72764326
127MP0000490_abnormal_crypts_of0.71810880
128MP0002078_abnormal_glucose_homeostasis0.71654575
129MP0009931_abnormal_skin_appearance0.71480466
130MP0002115_abnormal_skeleton_extremities0.70975252
131MP0003221_abnormal_cardiomyocyte_apopto0.70910477
132MP0002113_abnormal_skeleton_development0.67994551
133MP0001216_abnormal_epidermal_layer0.67356516
134MP0005257_abnormal_intraocular_pressure0.66247703
135MP0002933_joint_inflammation0.65425302
136MP0000477_abnormal_intestine_morphology0.65208172
137MP0003806_abnormal_nucleotide_metabolis0.63876450
138MP0004197_abnormal_fetal_growth/weight/0.63783468
139MP0005319_abnormal_enzyme/_coenzyme0.63612450
140MP0002118_abnormal_lipid_homeostasis0.63313886
141MP0002088_abnormal_embryonic_growth/wei0.62032130

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)3.19829843
2Subacute progressive viral hepatitis (HP:0006572)3.07936413
3Cervical subluxation (HP:0003308)3.05477374
4Hyperglycemia (HP:0003074)3.01594111
5Vertebral compression fractures (HP:0002953)2.94222353
6Ankle contracture (HP:0006466)2.79526884
7Protrusio acetabuli (HP:0003179)2.71768769
8Hypoglycemic seizures (HP:0002173)2.69534027
9Abnormality of the intrinsic pathway (HP:0010989)2.66079348
10Asymmetry of the thorax (HP:0001555)2.65031611
11Hyperinsulinemic hypoglycemia (HP:0000825)2.62486838
12Hematochezia (HP:0002573)2.57588269
13Myocardial infarction (HP:0001658)2.57459005
14Mucopolysacchariduria (HP:0008155)2.57397534
15Urinary glycosaminoglycan excretion (HP:0003541)2.57397534
16Syringomyelia (HP:0003396)2.51210189
17Spinal cord lesions (HP:0100561)2.51210189
18Metaphyseal cupping (HP:0003021)2.42756930
19Epiphyseal dysplasia (HP:0002656)2.39999760
20Abnormality of the common coagulation pathway (HP:0010990)2.39606248
21Spondylolisthesis (HP:0003302)2.38228924
22Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37497547
23Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37497547
24Abnormality of polysaccharide metabolism (HP:0011012)2.37497547
25Exostoses (HP:0100777)2.36975422
26Thoracolumbar scoliosis (HP:0002944)2.36009436
27Abnormality of the distal phalanges of the toes (HP:0010182)2.34746983
28Papillary thyroid carcinoma (HP:0002895)2.30347587
29Abnormality of complement system (HP:0005339)2.29231814
30Flat acetabular roof (HP:0003180)2.28910428
31Rectal prolapse (HP:0002035)2.28023537
32Polycythemia (HP:0001901)2.25730847
33Deep venous thrombosis (HP:0002625)2.24738949
34Aneurysm (HP:0002617)2.24363846
35Wormian bones (HP:0002645)2.24287557
36Mitral valve prolapse (HP:0001634)2.21114978
37Esophageal varix (HP:0002040)2.20392495
38Sparse lateral eyebrow (HP:0005338)2.19728611
39Enlarged penis (HP:0000040)2.19053197
40Ketoacidosis (HP:0001993)2.18665323
41Hepatocellular carcinoma (HP:0001402)2.18069465
42Aortic aneurysm (HP:0004942)2.17231748
43Abnormality of purine metabolism (HP:0004352)2.17098083
44Complement deficiency (HP:0004431)2.16755253
45Abnormal foot bone ossification (HP:0010675)2.16443123
46Micronodular cirrhosis (HP:0001413)2.12650504
47Gout (HP:0001997)2.12582390
48Cupped ribs (HP:0000887)2.10764876
49Ankyloglossia (HP:0010296)2.10547131
50Cortical dysplasia (HP:0002539)2.09617998
51Abnormality of the Achilles tendon (HP:0005109)2.09122132
52Atrophic scars (HP:0001075)2.09068633
53Late onset (HP:0003584)2.08760978
54Hemorrhage of the eye (HP:0011885)2.07421344
55Achilles tendon contracture (HP:0001771)2.06897432
56Short nail (HP:0001799)2.06354868
57Osteolytic defects of the hand bones (HP:0009699)2.05819913
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.05819913
59Autoimmune thrombocytopenia (HP:0001973)2.05222422
60Hyperacusis (HP:0010780)2.04977181
61Dysostosis multiplex (HP:0000943)2.04597983
62Peritonitis (HP:0002586)2.04114253
63Thin bony cortex (HP:0002753)2.02616396
64Intrahepatic cholestasis (HP:0001406)2.01661214
65Insulin-resistant diabetes mellitus (HP:0000831)2.01567551
66Hypoplastic ischia (HP:0003175)2.00317279
67Back pain (HP:0003418)1.99323704
68Cerebral aneurysm (HP:0004944)1.99244342
69Abnormality of monocarboxylic acid metabolism (HP:0010996)1.99186696
70Abnormality of carpal bone ossification (HP:0006257)1.98986180
71Abnormality of proline metabolism (HP:0010907)1.98836352
72Hydroxyprolinuria (HP:0003080)1.98836352
73Symptomatic seizures (HP:0011145)1.97036853
74Blue sclerae (HP:0000592)1.96309209
75Mitral stenosis (HP:0001718)1.95763689
76Macroorchidism (HP:0000053)1.94934209
77Aortic dissection (HP:0002647)1.94578102
78Abnormal pancreas size (HP:0012094)1.94327553
79Abnormality of the ischium (HP:0003174)1.93961066
80Abnormality of endocrine pancreas physiology (HP:0012093)1.93749265
81Abnormality of the pancreatic islet cells (HP:0006476)1.93749265
82Abnormality of oral frenula (HP:0000190)1.92149247
83Abnormal delivery (HP:0001787)1.90273615
84Genu recurvatum (HP:0002816)1.89310238
85Abnormal ossification of hand bones (HP:0005921)1.89154366
86Abnormal cartilage morphology (HP:0002763)1.87913034
87Protuberant abdomen (HP:0001538)1.87211751
88Right ventricular cardiomyopathy (HP:0011663)1.87211109
89Fragile skin (HP:0001030)1.86376506
90Shallow orbits (HP:0000586)1.86156177
91Long toe (HP:0010511)1.85852863
92Increased CSF protein (HP:0002922)1.85105373
93Distal lower limb muscle weakness (HP:0009053)1.84314207
94Insulin resistance (HP:0000855)1.84307004
95Growth hormone excess (HP:0000845)1.83550361
96Severe short stature (HP:0003510)1.82801575
97Interstitial pulmonary disease (HP:0006530)1.82243887
98Abnormal tarsal ossification (HP:0008369)1.82061961
99Exocrine pancreatic insufficiency (HP:0001738)1.81551203
100Tetraparesis (HP:0002273)1.81152306
101Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80853054
102Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80730664
103Persistence of primary teeth (HP:0006335)1.80185555
104Abnormality of the distal phalanx of the thumb (HP:0009617)1.80038806
105Ulnar bowing (HP:0003031)1.79785248
106Xanthomatosis (HP:0000991)1.79101407
107Abdominal distention (HP:0003270)1.77270296
108Hyperparathyroidism (HP:0000843)1.77183982
109Abnormal biliary tract morphology (HP:0012440)1.76149726
110Premature rupture of membranes (HP:0001788)1.75625230
111Arterial tortuosity (HP:0005116)1.75363973
112Milia (HP:0001056)1.74745223
113Cellulitis (HP:0100658)1.74517784
114Dilatation of the ascending aorta (HP:0005111)1.74406316
115Advanced eruption of teeth (HP:0006288)1.71090957
116Broad face (HP:0000283)1.69695168
117Biliary tract neoplasm (HP:0100574)1.68866547
118Segmental peripheral demyelination/remyelination (HP:0003481)1.68607621
119Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68517426
120Ketosis (HP:0001946)1.68042776
121Abnormality of the fingertips (HP:0001211)1.67217087
122Spastic diplegia (HP:0001264)1.67123368
123Vertebral arch anomaly (HP:0008438)1.66380520
124Systemic lupus erythematosus (HP:0002725)1.65763362
125Hyperextensible skin (HP:0000974)1.65570377
126Elbow flexion contracture (HP:0002987)1.65558780
127Bladder diverticulum (HP:0000015)1.65505100
128Abnormality of the gastric mucosa (HP:0004295)1.65499469
129Gastrointestinal infarctions (HP:0005244)1.64070641
130Bone pain (HP:0002653)1.64024505
131Hypercholesterolemia (HP:0003124)1.63137318
132Striae distensae (HP:0001065)1.62947031
133Vascular tortuosity (HP:0004948)1.62789981
134Platyspondyly (HP:0000926)1.62684326
135Glomerulonephritis (HP:0000099)1.61853208
136Distal lower limb amyotrophy (HP:0008944)1.61785256
137Orthostatic hypotension (HP:0001278)1.61305860
138Delayed cranial suture closure (HP:0000270)1.60644302
139Transitional cell carcinoma of the bladder (HP:0006740)1.60506598
140Fatigue (HP:0012378)1.59595827
141Joint laxity (HP:0001388)1.59285043
142Camptodactyly of toe (HP:0001836)1.59043935
143Thyroid carcinoma (HP:0002890)1.58839488
144Abnormality of the acetabulum (HP:0003170)1.58674547
145Cardiovascular calcification (HP:0011915)1.58445590
146Broad metatarsal (HP:0001783)1.58332505
147Deep philtrum (HP:0002002)1.57219179
148Abnormality of Sharpey fibers (HP:0100685)1.56921803
149Chondrocalcinosis (HP:0000934)1.56854287
150Breech presentation (HP:0001623)1.55754087
151Biconcave vertebral bodies (HP:0004586)1.55391556
152Elevated alkaline phosphatase (HP:0003155)1.55353302
153Polygenic inheritance (HP:0010982)1.54933621
154Absent frontal sinuses (HP:0002688)1.54377286
155Nonimmune hydrops fetalis (HP:0001790)1.53534170
156Stroke (HP:0001297)1.53066303
157Abnormality of the thoracic spine (HP:0100711)1.52739853
158Centrally nucleated skeletal muscle fibers (HP:0003687)1.52593824
159Termporal pattern (HP:0011008)1.52581727
160Insidious onset (HP:0003587)1.52581727
161Eczematoid dermatitis (HP:0000976)1.52483089
162Abnormality of the lumbar spine (HP:0100712)1.52087353
163Coarse hair (HP:0002208)1.50222865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.24758050
2LATS14.10477595
3SMG12.78906358
4PKN22.77565824
5ERN12.74492976
6FRK2.73881439
7PRPF4B2.47684006
8TAOK32.44868866
9EEF2K2.05489146
10STK32.05054768
11IRAK32.04772559
12PTK61.97638074
13TESK11.96129275
14MAP3K21.92007058
15SIK11.67362441
16LRRK21.64056096
17MAP3K31.59501315
18EPHA31.59218677
19STK101.59006047
20SCYL21.51740922
21NEK91.51638267
22RIPK11.51445497
23FGFR31.48105346
24ICK1.47585537
25ERBB41.46399447
26JAK31.45372024
27STK38L1.45185281
28PRKD31.43894279
29CDK61.43109471
30FGFR41.42209619
31PDGFRA1.41405091
32FLT31.40725398
33RPS6KA41.39584383
34EPHB11.31780497
35HIPK21.24247112
36JAK11.24022293
37RET1.22958116
38PTK21.20452616
39TESK21.20257685
40MAP3K101.18859092
41NLK1.18647590
42LATS21.18271966
43MAP3K131.17564716
44KSR21.16561103
45CDK121.15547996
46MAP2K31.15390084
47ACVR1B1.13392277
48DDR21.12667179
49NME21.07859238
50EPHA21.05720278
51PDGFRB1.05402085
52TBK11.04515166
53STK241.04443599
54MET1.01468245
55DMPK0.99283692
56MAPKAPK30.97710465
57TAOK10.96193518
58TTN0.95216171
59JAK20.94638148
60MTOR0.92467489
61PBK0.92246266
62MAP3K10.91459949
63CHUK0.91194558
64PASK0.90669282
65MST1R0.89286909
66ARAF0.88886652
67FER0.88097344
68INSRR0.87009210
69MST40.86529138
70BMX0.85133910
71MELK0.85009540
72TYK20.84619953
73BRD40.84262929
74EIF2AK10.82312987
75TGFBR10.79079515
76TAOK20.76497655
77CDK80.76275147
78CDK90.76204290
79CDK70.75522458
80YES10.75196540
81MAP3K60.73638231
82DYRK1B0.71329344
83NUAK10.71019893
84CLK10.71012676
85TIE10.69349326
86TGFBR20.68063493
87ZAP700.67965033
88CAMK1D0.66867941
89GSK3A0.65859193
90PIM10.65068034
91TRPM70.64618495
92EIF2AK30.63638630
93MAP3K80.62861540
94MAP2K20.62328011
95PIK3CG0.62067348
96MAP3K90.61573360
97RPS6KB20.59866823
98MYLK0.58187049
99MAP3K50.55073937
100FGFR10.55044151
101ITK0.54450283
102SIK30.53567127
103MATK0.52327629
104RPS6KA20.51283170
105MAPK150.50886528
106PAK40.50608943
107BRSK20.49813966
108LMTK20.49745968
109AKT30.49534602
110MAP2K10.49062432
111RAF10.46616760
112MOS0.45704568
113WNK40.45538592
114IRAK40.45455503
115MARK20.45452462
116BMPR20.45077446
117KDR0.45035266
118FGFR20.44532045
119MAP3K140.44246073
120CDC42BPA0.44052714
121PRKAA10.43745828
122PRKG20.43393900
123CDK40.42710318
124NEK20.42519724
125MAPK70.42164570
126AKT20.42030933
127CSF1R0.42020752
128ILK0.41806494
129MAPK110.41515212
130ERBB20.38006633
131NTRK10.36181902
132IGF1R0.35433207
133IKBKE0.34865611
134PDPK10.34162414
135PAK20.34077535
136PRKCH0.33369610
137ABL10.32922061
138EGFR0.32303909
139BCKDK0.31984116

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.37002998
2Nitrogen metabolism_Homo sapiens_hsa009102.98875280
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.33167618
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.32566287
5Sulfur metabolism_Homo sapiens_hsa009202.16003293
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72227861
7Caffeine metabolism_Homo sapiens_hsa002321.69244512
8Selenocompound metabolism_Homo sapiens_hsa004501.56595573
9Other glycan degradation_Homo sapiens_hsa005111.56454625
10Insulin resistance_Homo sapiens_hsa049311.55865048
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55665785
12Pentose phosphate pathway_Homo sapiens_hsa000301.54863274
13Pancreatic cancer_Homo sapiens_hsa052121.48847265
14Adherens junction_Homo sapiens_hsa045201.45205643
15Small cell lung cancer_Homo sapiens_hsa052221.41967094
16Prion diseases_Homo sapiens_hsa050201.40973055
17Chronic myeloid leukemia_Homo sapiens_hsa052201.38736358
18Prolactin signaling pathway_Homo sapiens_hsa049171.37398980
19mTOR signaling pathway_Homo sapiens_hsa041501.35926741
20Bladder cancer_Homo sapiens_hsa052191.27599811
21Toxoplasmosis_Homo sapiens_hsa051451.23196303
22Shigellosis_Homo sapiens_hsa051311.19891993
23Phenylalanine metabolism_Homo sapiens_hsa003601.18886315
24ECM-receptor interaction_Homo sapiens_hsa045121.18255048
25Protein digestion and absorption_Homo sapiens_hsa049741.17840041
26B cell receptor signaling pathway_Homo sapiens_hsa046621.16343932
27Amoebiasis_Homo sapiens_hsa051461.15903354
28TNF signaling pathway_Homo sapiens_hsa046681.13264647
29Biosynthesis of amino acids_Homo sapiens_hsa012301.12075256
30Fat digestion and absorption_Homo sapiens_hsa049751.11355216
31Focal adhesion_Homo sapiens_hsa045101.11089894
32Proteoglycans in cancer_Homo sapiens_hsa052051.10276740
33Arginine biosynthesis_Homo sapiens_hsa002201.10131049
34TGF-beta signaling pathway_Homo sapiens_hsa043501.08429652
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08402438
36Fatty acid degradation_Homo sapiens_hsa000711.08074788
37Endometrial cancer_Homo sapiens_hsa052131.07322998
38Thyroid cancer_Homo sapiens_hsa052161.06621616
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06605814
40Leishmaniasis_Homo sapiens_hsa051401.04968310
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.03051434
42Legionellosis_Homo sapiens_hsa051341.03034303
43Prostate cancer_Homo sapiens_hsa052151.02830180
44Dorso-ventral axis formation_Homo sapiens_hsa043201.02404304
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97256699
46MicroRNAs in cancer_Homo sapiens_hsa052060.97228545
47Hepatitis B_Homo sapiens_hsa051610.93500103
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89075623
49FoxO signaling pathway_Homo sapiens_hsa040680.88790764
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88221524
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87622305
52Type II diabetes mellitus_Homo sapiens_hsa049300.87182435
53Acute myeloid leukemia_Homo sapiens_hsa052210.85543579
54Fructose and mannose metabolism_Homo sapiens_hsa000510.84737226
55Carbon metabolism_Homo sapiens_hsa012000.84520135
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.84376776
57Starch and sucrose metabolism_Homo sapiens_hsa005000.83713217
58Colorectal cancer_Homo sapiens_hsa052100.83484067
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.83346375
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.82496791
61Osteoclast differentiation_Homo sapiens_hsa043800.82005983
62Fatty acid biosynthesis_Homo sapiens_hsa000610.80161322
63ErbB signaling pathway_Homo sapiens_hsa040120.80040902
64Complement and coagulation cascades_Homo sapiens_hsa046100.79585737
65Lysine degradation_Homo sapiens_hsa003100.79229065
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77868951
67N-Glycan biosynthesis_Homo sapiens_hsa005100.77831648
68AMPK signaling pathway_Homo sapiens_hsa041520.76534776
69PPAR signaling pathway_Homo sapiens_hsa033200.75917471
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75724237
71Tryptophan metabolism_Homo sapiens_hsa003800.74938194
72Pertussis_Homo sapiens_hsa051330.74575281
73Non-small cell lung cancer_Homo sapiens_hsa052230.74270372
74Lysosome_Homo sapiens_hsa041420.74231247
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71870691
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.71149119
77VEGF signaling pathway_Homo sapiens_hsa043700.70914960
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70545308
79Insulin signaling pathway_Homo sapiens_hsa049100.70196976
80Bile secretion_Homo sapiens_hsa049760.69799287
81Renal cell carcinoma_Homo sapiens_hsa052110.69663423
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.69061717
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68819046
84Herpes simplex infection_Homo sapiens_hsa051680.68237999
85p53 signaling pathway_Homo sapiens_hsa041150.68084218
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67700801
87Viral carcinogenesis_Homo sapiens_hsa052030.67619753
88Hippo signaling pathway_Homo sapiens_hsa043900.67505849
89Fatty acid metabolism_Homo sapiens_hsa012120.67109247
90HIF-1 signaling pathway_Homo sapiens_hsa040660.67017582
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66902548
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.66507478
93Salmonella infection_Homo sapiens_hsa051320.64584136
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64560215
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64224009
96Inositol phosphate metabolism_Homo sapiens_hsa005620.63910615
97Influenza A_Homo sapiens_hsa051640.63738852
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63317263
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63112027
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.62984798
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62603000
102Endocytosis_Homo sapiens_hsa041440.61485295
103Glucagon signaling pathway_Homo sapiens_hsa049220.61161413
104Apoptosis_Homo sapiens_hsa042100.60930226
105Thyroid hormone synthesis_Homo sapiens_hsa049180.60703698
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60407152
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.60386644
108Circadian rhythm_Homo sapiens_hsa047100.59502219
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59436411
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.59299108
111Sphingolipid metabolism_Homo sapiens_hsa006000.58320957
112Protein export_Homo sapiens_hsa030600.57868724
113Vibrio cholerae infection_Homo sapiens_hsa051100.57773682
114Folate biosynthesis_Homo sapiens_hsa007900.57410451
115Antigen processing and presentation_Homo sapiens_hsa046120.57141116
116Measles_Homo sapiens_hsa051620.56992586
117Notch signaling pathway_Homo sapiens_hsa043300.56815124
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.56297668
119Hepatitis C_Homo sapiens_hsa051600.54073420
120Glioma_Homo sapiens_hsa052140.53855660
121T cell receptor signaling pathway_Homo sapiens_hsa046600.53110509
122Pathways in cancer_Homo sapiens_hsa052000.53010661
123HTLV-I infection_Homo sapiens_hsa051660.52993537
124Viral myocarditis_Homo sapiens_hsa054160.52465132
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52229419
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51612405
127Choline metabolism in cancer_Homo sapiens_hsa052310.50913472
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49937338
129Platelet activation_Homo sapiens_hsa046110.49329499
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48924023
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47761420
132Tuberculosis_Homo sapiens_hsa051520.47682508
133Renin-angiotensin system_Homo sapiens_hsa046140.47596236
134Pancreatic secretion_Homo sapiens_hsa049720.47191723
135Galactose metabolism_Homo sapiens_hsa000520.45882748
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45425827

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