GOPC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.55701165
2hemidesmosome assembly (GO:0031581)5.43825836
3nuclear pore organization (GO:0006999)5.11554898
4regulation of mitotic spindle organization (GO:0060236)4.37328539
5cell adhesion mediated by integrin (GO:0033627)4.18165367
6synaptic vesicle maturation (GO:0016188)4.05625973
7pore complex assembly (GO:0046931)3.96545333
8locomotory exploration behavior (GO:0035641)3.95566569
9L-phenylalanine catabolic process (GO:0006559)3.65897649
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.65897649
11mitotic sister chromatid cohesion (GO:0007064)3.54060038
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.46797043
13layer formation in cerebral cortex (GO:0021819)3.45424103
14desmosome organization (GO:0002934)3.36861867
15skin morphogenesis (GO:0043589)3.36653533
16collagen fibril organization (GO:0030199)3.35455650
17glutamate secretion (GO:0014047)3.34841136
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.33990919
19L-phenylalanine metabolic process (GO:0006558)3.33784750
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.33784750
21dicarboxylic acid biosynthetic process (GO:0043650)3.29271222
22cell-substrate junction assembly (GO:0007044)3.24337287
23regulation of synaptic vesicle exocytosis (GO:2000300)3.24034427
24Golgi transport vesicle coating (GO:0048200)3.21462768
25COPI coating of Golgi vesicle (GO:0048205)3.21462768
26cellular ketone body metabolic process (GO:0046950)3.19143573
27synaptic vesicle exocytosis (GO:0016079)3.18607245
28vocalization behavior (GO:0071625)3.11702972
29endodermal cell differentiation (GO:0035987)3.09427928
30activation of protein kinase A activity (GO:0034199)3.04484797
31positive regulation of dendritic spine morphogenesis (GO:0061003)3.03355959
32cytoplasmic mRNA processing body assembly (GO:0033962)3.01965973
33regulation of spindle organization (GO:0090224)3.01604759
34alpha-linolenic acid metabolic process (GO:0036109)3.00096376
35positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.99165489
36COPII vesicle coating (GO:0048208)2.98329377
37aromatic amino acid family catabolic process (GO:0009074)2.97886129
38glutamate metabolic process (GO:0006536)2.96869931
39mitotic chromosome condensation (GO:0007076)2.96711541
40hypotonic response (GO:0006971)2.94641073
41protein localization to endosome (GO:0036010)2.93956070
42exploration behavior (GO:0035640)2.92786313
43neurotransmitter secretion (GO:0007269)2.91601153
44negative regulation of fibrinolysis (GO:0051918)2.90590056
45pyrimidine nucleobase catabolic process (GO:0006208)2.90016712
46cytoskeleton-dependent cytokinesis (GO:0061640)2.87441987
47nucleobase catabolic process (GO:0046113)2.85140489
48ribosome assembly (GO:0042255)2.84872422
49mitotic cytokinesis (GO:0000281)2.84493854
50lens morphogenesis in camera-type eye (GO:0002089)2.83743128
51chondrocyte proliferation (GO:0035988)2.83169555
52regulation of transforming growth factor beta2 production (GO:0032909)2.83092502
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80589541
54ketone body metabolic process (GO:1902224)2.78974548
55gamma-aminobutyric acid transport (GO:0015812)2.78658684
56bile acid biosynthetic process (GO:0006699)2.73262874
57kynurenine metabolic process (GO:0070189)2.72660881
58protein hydroxylation (GO:0018126)2.71222824
59synaptic vesicle docking involved in exocytosis (GO:0016081)2.70320275
60vesicle transport along microtubule (GO:0047496)2.68322249
61protein targeting to Golgi (GO:0000042)2.67659385
62complement activation, alternative pathway (GO:0006957)2.66942039
63vesicle coating (GO:0006901)2.65809539
64negative regulation of fibroblast apoptotic process (GO:2000270)2.65235958
65regulation of glutamate receptor signaling pathway (GO:1900449)2.64979493
66triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.64965635
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64840019
68regulation of synaptic vesicle transport (GO:1902803)2.64776279
69regulation of fibrinolysis (GO:0051917)2.64745834
70regulation of dendritic spine morphogenesis (GO:0061001)2.62789489
71glyoxylate metabolic process (GO:0046487)2.62469513
72peptidyl-glutamic acid carboxylation (GO:0017187)2.60452469
73protein carboxylation (GO:0018214)2.60452469
74cellular potassium ion homeostasis (GO:0030007)2.58544955
75lysine catabolic process (GO:0006554)2.56662292
76lysine metabolic process (GO:0006553)2.56662292
77negative regulation of chondrocyte differentiation (GO:0032331)2.56238449
78regulation of long-term neuronal synaptic plasticity (GO:0048169)2.54845552
79urea cycle (GO:0000050)2.54467773
80urea metabolic process (GO:0019627)2.54467773
81cysteine metabolic process (GO:0006534)2.53622984
82coenzyme catabolic process (GO:0009109)2.53410669
83regulation of RNA export from nucleus (GO:0046831)2.52112532
84regulation of protein activation cascade (GO:2000257)2.51594925
85dendritic spine morphogenesis (GO:0060997)2.51435876
86negative regulation of stem cell proliferation (GO:2000647)2.51255718
87dendrite morphogenesis (GO:0048813)2.51086812
88glycoprotein catabolic process (GO:0006516)2.50678187
89morphogenesis of an epithelial sheet (GO:0002011)2.50550393
90regulation of cAMP-dependent protein kinase activity (GO:2000479)2.50463476
91clathrin coat assembly (GO:0048268)2.50449572
92sodium ion export (GO:0071436)2.49879311
93insulin-like growth factor receptor signaling pathway (GO:0048009)2.49719685
94neuron cell-cell adhesion (GO:0007158)2.49061825
95polyol transport (GO:0015791)2.48782588
96establishment of protein localization to Golgi (GO:0072600)2.48100978
97protein localization to synapse (GO:0035418)2.46444866
98proline transport (GO:0015824)2.45299994
99axon extension (GO:0048675)2.44857854
100regulation of NFAT protein import into nucleus (GO:0051532)2.44143428
101neuronal action potential propagation (GO:0019227)2.44054038
102organelle transport along microtubule (GO:0072384)2.42966247
103regulation of cholesterol homeostasis (GO:2000188)2.42347097
104extracellular matrix assembly (GO:0085029)2.41301089
105DNA topological change (GO:0006265)2.40637985
106regulation of synapse structural plasticity (GO:0051823)2.40186475
107regulation of clathrin-mediated endocytosis (GO:2000369)2.39885191
108regulation of nucleobase-containing compound transport (GO:0032239)2.39774763
109negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.39010040
110cellular protein complex localization (GO:0034629)2.38945754
111retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.38010237
112neuron recognition (GO:0008038)2.37901035
113retina vasculature morphogenesis in camera-type eye (GO:0061299)2.37555753
114regulation of complement activation (GO:0030449)2.37054779
115mating behavior (GO:0007617)2.36577205
116regulation of neuronal synaptic plasticity (GO:0048168)2.35973959
117neuromuscular process controlling balance (GO:0050885)2.35970101
118DNA synthesis involved in DNA repair (GO:0000731)2.35400385
119acylglycerol catabolic process (GO:0046464)2.34946631
120neutral lipid catabolic process (GO:0046461)2.34946631
121endoplasmic reticulum organization (GO:0007029)2.34824271
122indole-containing compound catabolic process (GO:0042436)2.34696075
123indolalkylamine catabolic process (GO:0046218)2.34696075
124tryptophan catabolic process (GO:0006569)2.34696075
125high-density lipoprotein particle remodeling (GO:0034375)2.34447029
126ionotropic glutamate receptor signaling pathway (GO:0035235)2.33294808
127peptidyl-proline hydroxylation (GO:0019511)2.32468228
128regulation of protein export from nucleus (GO:0046825)2.31812429
129regulation of ARF protein signal transduction (GO:0032012)2.31327536
130localization within membrane (GO:0051668)2.30177663
131neuron projection extension (GO:1990138)2.29469923
132bile acid metabolic process (GO:0008206)2.29296030
133negative regulation of dendrite morphogenesis (GO:0050774)2.29013686
134drug transmembrane transport (GO:0006855)2.29008220
135negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.28893933
136cellular modified amino acid catabolic process (GO:0042219)2.28851097
137negative regulation of anoikis (GO:2000811)2.28680136
138regulation of glucose import in response to insulin stimulus (GO:2001273)2.27878356
139proximal/distal pattern formation (GO:0009954)2.27835881
140dosage compensation (GO:0007549)2.27352030
141protein export from nucleus (GO:0006611)2.27083990
142glutamate receptor signaling pathway (GO:0007215)2.26935625
143retrograde transport, vesicle recycling within Golgi (GO:0000301)2.26663377
144kidney mesenchyme development (GO:0072074)2.26108423
145dicarboxylic acid catabolic process (GO:0043649)2.25970501
146peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.25957812
147cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.25787716
148cellular response to vitamin D (GO:0071305)2.25520587
149cytoskeletal anchoring at plasma membrane (GO:0007016)2.25174858
150G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.23835076
151cell migration involved in sprouting angiogenesis (GO:0002042)2.23451360
152regulation of dendritic spine development (GO:0060998)2.23073213
153suckling behavior (GO:0001967)2.22661689
154cerebellar granule cell differentiation (GO:0021707)2.21944833
155cerebral cortex cell migration (GO:0021795)2.21937848
156pre-miRNA processing (GO:0031054)2.21565844
157axonal fasciculation (GO:0007413)2.21177085
158embryonic process involved in female pregnancy (GO:0060136)2.20892351
159acetyl-CoA metabolic process (GO:0006084)2.20593446
160dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.20265575
161regulation of excitatory postsynaptic membrane potential (GO:0060079)2.19870361
162chondrocyte development (GO:0002063)2.19038597
163central nervous system projection neuron axonogenesis (GO:0021952)2.19001384
164sister chromatid segregation (GO:0000819)2.18866638
165negative regulation of fatty acid transport (GO:2000192)2.18350620
166midgut development (GO:0007494)2.17973013
167positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.17971391
168positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.17971391
169positive regulation of mitotic sister chromatid separation (GO:1901970)2.17971391
170neurotransmitter transport (GO:0006836)2.17832043
171aspartate family amino acid catabolic process (GO:0009068)2.17772973
172stress granule assembly (GO:0034063)2.17300064
173negative regulation of keratinocyte proliferation (GO:0010839)2.17249982
174negative regulation of potassium ion transmembrane transport (GO:1901380)2.16610035
175sulfur amino acid catabolic process (GO:0000098)2.16309095
176nitrogen cycle metabolic process (GO:0071941)2.15758168
177regulation of neurotransmitter levels (GO:0001505)2.15193326
178histone H3-K9 demethylation (GO:0033169)2.14519024
179positive regulation of fibroblast migration (GO:0010763)2.13209694
180paraxial mesoderm development (GO:0048339)2.12798540
181protein ADP-ribosylation (GO:0006471)2.12500805
182cellular response to vitamin (GO:0071295)2.12062166
183interkinetic nuclear migration (GO:0022027)2.11428352
184nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.11337998
185cell-substrate adherens junction assembly (GO:0007045)2.10211709
186focal adhesion assembly (GO:0048041)2.10211709
187peptidyl-lysine dimethylation (GO:0018027)2.09610915
188regulation of plasminogen activation (GO:0010755)2.08496504
189substrate-dependent cell migration (GO:0006929)2.08403449
190cerebral cortex radially oriented cell migration (GO:0021799)2.08338027
191wound healing, spreading of epidermal cells (GO:0035313)2.08199018
192histone H2B ubiquitination (GO:0033523)2.07313988
193sequestering of extracellular ligand from receptor (GO:0035581)2.06599849
194metanephric mesenchyme development (GO:0072075)2.06339891
195bone trabecula formation (GO:0060346)2.05915072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.76094873
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.60427149
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.40879700
4EZH2_22144423_ChIP-Seq_EOC_Human3.02094135
5E2F7_22180533_ChIP-Seq_HELA_Human2.88869162
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.86185466
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.85798448
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.47552804
9AR_21909140_ChIP-Seq_LNCAP_Human2.43446078
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.29841091
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29384167
12GBX2_23144817_ChIP-Seq_PC3_Human2.23251828
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.18762523
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18207881
15BRD4_25478319_ChIP-Seq_HGPS_Human2.17394501
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.15987461
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10081019
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07083308
19FUS_26573619_Chip-Seq_HEK293_Human2.04790122
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.02342687
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.96849013
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.95425347
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95045291
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92459683
25DROSHA_22980978_ChIP-Seq_HELA_Human1.88407212
26AR_21572438_ChIP-Seq_LNCaP_Human1.87653514
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87132829
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86406235
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86114301
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83109776
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80359876
32TAF15_26573619_Chip-Seq_HEK293_Human1.79498017
33* RARB_27405468_Chip-Seq_BRAIN_Mouse1.79441165
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79266349
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79266349
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.78498244
37* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.76524884
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74498188
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72307758
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.71154200
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70849107
42TCF4_18268006_ChIP-ChIP_LS174T_Human1.69757376
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.68641309
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62013562
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60927607
46REST_21632747_ChIP-Seq_MESCs_Mouse1.59749073
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55082815
48CJUN_26792858_Chip-Seq_BT549_Human1.52585394
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52463966
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52422374
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48356995
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46631113
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45875156
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44017757
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44017757
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42932931
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42460124
58SMAD4_21799915_ChIP-Seq_A2780_Human1.42036937
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39824926
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39125718
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.38500321
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.38383791
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38336890
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36184686
65TP53_16413492_ChIP-PET_HCT116_Human1.35778202
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.35108214
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34015481
68CLOCK_20551151_ChIP-Seq_293T_Human1.33525790
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33464092
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33143174
71ZNF274_21170338_ChIP-Seq_K562_Hela1.32658074
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32461212
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32461212
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.31680767
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.29380914
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.28330348
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27731352
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27419950
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.27355717
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.27147509
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26462670
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.25898376
83* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.25148908
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25004773
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24984007
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24505714
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24327991
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23950567
89* SOX9_26525672_Chip-Seq_HEART_Mouse1.23467261
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22452756
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22245975
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21627452
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21149444
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21089656
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20418587
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20401250
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.20193254
98JUN_21703547_ChIP-Seq_K562_Human1.19566122
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19329278
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19215420
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18288399
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17088397
103IGF1R_20145208_ChIP-Seq_DFB_Human1.16724641
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.16505329
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15362685
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14032262
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13952345
108ELK1_19687146_ChIP-ChIP_HELA_Human1.13465697
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.12118537
110P300_19829295_ChIP-Seq_ESCs_Human1.11961632
111WT1_19549856_ChIP-ChIP_CCG9911_Human1.11845913
112AR_25329375_ChIP-Seq_VCAP_Human1.10854785
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.10750360
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.09288206
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09145253
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09144991
117FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08976516
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.08928064
119BCAT_22108803_ChIP-Seq_LS180_Human1.08299379
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.07975027
121EWS_26573619_Chip-Seq_HEK293_Human1.07765978
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07731898
123AHR_22903824_ChIP-Seq_MCF-7_Human1.07650671
124* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06867387
125CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06826868
126KDM2B_26808549_Chip-Seq_K562_Human1.06572210
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06432683
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.05134565
129STAT3_23295773_ChIP-Seq_U87_Human1.04755402
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04469470
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03593746
132ZNF263_19887448_ChIP-Seq_K562_Human1.02833880
133TP53_18474530_ChIP-ChIP_U2OS_Human1.02183749
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02131344
135RXR_22108803_ChIP-Seq_LS180_Human1.02036994
136SMAD4_21741376_ChIP-Seq_HESCs_Human1.00202658
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99854797
138* AR_19668381_ChIP-Seq_PC3_Human0.99747837
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99644850
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.98497478
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95895682
142DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95645471
143* TP63_23658742_ChIP-Seq_EP156T_Human0.95622718
144* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95229933
145TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94304480
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.94234170
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94175166
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.94027370
149SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93819672
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93727577
151GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92525113
152* EZH2_27294783_Chip-Seq_NPCs_Mouse0.92511446
153P53_22387025_ChIP-Seq_ESCs_Mouse0.91726325
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91175276
155EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90896022
156* TCF4_23295773_ChIP-Seq_U87_Human0.90828684
157PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90425652
158ESR2_21235772_ChIP-Seq_MCF-7_Human0.90297381
159PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89051105
160ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88927073
161* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88647881
162MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88369104
163NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88332185
164ISL1_27105846_Chip-Seq_CPCs_Mouse0.88009344
165IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87990715
166TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87421302
167TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87265553
168RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86828528
169KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86129678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.36120551
2MP0004859_abnormal_synaptic_plasticity4.56670758
3MP0002139_abnormal_hepatobiliary_system4.25806366
4MP0005360_urolithiasis3.74978140
5MP0005275_abnormal_skin_tensile3.55530935
6MP0010352_gastrointestinal_tract_polyps3.21988218
7MP0004272_abnormal_basement_membrane3.04435136
8MP0005085_abnormal_gallbladder_physiolo3.03512497
9MP0009780_abnormal_chondrocyte_physiolo2.96412886
10MP0010234_abnormal_vibrissa_follicle2.88804191
11MP0004270_analgesia2.80419089
12MP0003635_abnormal_synaptic_transmissio2.75362772
13MP0005365_abnormal_bile_salt2.64639625
14MP0003880_abnormal_central_pattern2.63939246
15MP0005503_abnormal_tendon_morphology2.54683641
16MP0008875_abnormal_xenobiotic_pharmacok2.47852504
17MP0003329_amyloid_beta_deposits2.45218301
18MP0003252_abnormal_bile_duct2.19779693
19MP0002063_abnormal_learning/memory/cond2.08319600
20MP0003566_abnormal_cell_adhesion2.07280243
21MP0009745_abnormal_behavioral_response2.05072250
22MP0003941_abnormal_skin_development1.99572627
23MP0003385_abnormal_body_wall1.99034924
24MP0006054_spinal_hemorrhage1.93697509
25MP0002064_seizures1.92578681
26MP0010329_abnormal_lipoprotein_level1.92164013
27MP0003705_abnormal_hypodermis_morpholog1.91909745
28MP0002909_abnormal_adrenal_gland1.91480868
29MP0002837_dystrophic_cardiac_calcinosis1.90727974
30MP0002822_catalepsy1.88557248
31MP0001958_emphysema1.87240053
32MP0009046_muscle_twitch1.87001006
33MP0005409_darkened_coat_color1.86142267
34MP0003279_aneurysm1.80928034
35MP0001968_abnormal_touch/_nociception1.78849295
36MP0002060_abnormal_skin_morphology1.76240067
37MP0005257_abnormal_intraocular_pressure1.71991098
38MP0000604_amyloidosis1.70823520
39MP0003195_calcinosis1.66009688
40MP0002234_abnormal_pharynx_morphology1.60069829
41MP0002572_abnormal_emotion/affect_behav1.58751144
42MP0002735_abnormal_chemical_nociception1.58295853
43MP0000013_abnormal_adipose_tissue1.55601269
44MP0003868_abnormal_feces_composition1.55003438
45MP0002734_abnormal_mechanical_nocicepti1.52572795
46MP0008057_abnormal_DNA_replication1.51710843
47MP0002009_preneoplasia1.50152497
48MP0003122_maternal_imprinting1.48259730
49MP0004130_abnormal_muscle_cell1.46319468
50MP0000579_abnormal_nail_morphology1.45112833
51MP0002272_abnormal_nervous_system1.44039334
52MP0003091_abnormal_cell_migration1.42132622
53MP0001501_abnormal_sleep_pattern1.41912998
54MP0005167_abnormal_blood-brain_barrier1.41784921
55MP0000762_abnormal_tongue_morphology1.41066718
56MP0000566_synostosis1.40014011
57MP0002877_abnormal_melanocyte_morpholog1.37277978
58MP0002736_abnormal_nociception_after1.36869167
59MP0003633_abnormal_nervous_system1.36572583
60MP0001440_abnormal_grooming_behavior1.36155724
61MP0008058_abnormal_DNA_repair1.31532442
62MP0004858_abnormal_nervous_system1.31363242
63MP0004185_abnormal_adipocyte_glucose1.30151143
64MP0000428_abnormal_craniofacial_morphol1.29532371
65MP0001348_abnormal_lacrimal_gland1.28478349
66MP0001661_extended_life_span1.27455467
67MP0002118_abnormal_lipid_homeostasis1.27025834
68MP0002733_abnormal_thermal_nociception1.26164726
69MP0005332_abnormal_amino_acid1.25736143
70MP0003115_abnormal_respiratory_system1.24412671
71MP0003191_abnormal_cellular_cholesterol1.21881904
72MP0005083_abnormal_biliary_tract1.20774685
73MP0003221_abnormal_cardiomyocyte_apopto1.19730651
74MP0001915_intracranial_hemorrhage1.18420918
75MP0000767_abnormal_smooth_muscle1.16968763
76MP0001486_abnormal_startle_reflex1.15299346
77MP0004134_abnormal_chest_morphology1.14950966
78MP0005386_behavior/neurological_phenoty1.14646779
79MP0004924_abnormal_behavior1.14646779
80MP0005584_abnormal_enzyme/coenzyme_acti1.13877803
81MP0000920_abnormal_myelination1.13354562
82MP0004233_abnormal_muscle_weight1.12157636
83MP0000778_abnormal_nervous_system1.11577723
84MP0004811_abnormal_neuron_physiology1.11428363
85MP0008961_abnormal_basal_metabolism1.11177491
86MP0002108_abnormal_muscle_morphology1.10124556
87MP0001666_abnormal_nutrient_absorption1.08609842
88MP0002138_abnormal_hepatobiliary_system1.08565181
89MP0003935_abnormal_craniofacial_develop1.08369754
90MP0002067_abnormal_sensory_capabilities1.08100559
91MP0003303_peritoneal_inflammation1.07458104
92MP0008874_decreased_physiological_sensi1.06260043
93MP0003045_fibrosis1.06032654
94MP0003631_nervous_system_phenotype1.05287341
95MP0003755_abnormal_palate_morphology1.05106283
96MP0009697_abnormal_copulation1.04849490
97MP0000003_abnormal_adipose_tissue1.02837697
98MP0009053_abnormal_anal_canal1.02591441
99MP0009384_cardiac_valve_regurgitation1.02572776
100MP0008569_lethality_at_weaning1.02529136
101MP0005535_abnormal_body_temperature1.01999930
102MP0004885_abnormal_endolymph1.01814198
103MP0003690_abnormal_glial_cell1.01486204
104MP0003283_abnormal_digestive_organ0.99889169
105MP0002396_abnormal_hematopoietic_system0.99428480
106MP0000733_abnormal_muscle_development0.99077008
107MP0003075_altered_response_to0.98693030
108MP0003950_abnormal_plasma_membrane0.98384053
109MP0000955_abnormal_spinal_cord0.98095540
110MP0008007_abnormal_cellular_replicative0.97335178
111MP0003172_abnormal_lysosome_physiology0.97288399
112MP0000759_abnormal_skeletal_muscle0.96171174
113MP0003183_abnormal_peptide_metabolism0.95763824
114MP0005623_abnormal_meninges_morphology0.95540078
115MP0002114_abnormal_axial_skeleton0.95356401
116MP0010094_abnormal_chromosome_stability0.94890822
117MP0001970_abnormal_pain_threshold0.94556626
118MP0000534_abnormal_ureter_morphology0.94495263
119MP0003879_abnormal_hair_cell0.93994501
120MP0002876_abnormal_thyroid_physiology0.93496941
121MP0004197_abnormal_fetal_growth/weight/0.93012526
122MP0001730_embryonic_growth_arrest0.92775160
123MP0002084_abnormal_developmental_patter0.92522048
124MP0001188_hyperpigmentation0.92469320
125MP0000569_abnormal_digit_pigmentation0.92440608
126MP0003300_gastrointestinal_ulcer0.92389411
127MP0003942_abnormal_urinary_system0.92081012
128MP0000751_myopathy0.91531483
129MP0001177_atelectasis0.91048035
130MP0003937_abnormal_limbs/digits/tail_de0.90069759
131MP0002066_abnormal_motor_capabilities/c0.89459522
132MP0002184_abnormal_innervation0.89053985
133MP0000609_abnormal_liver_physiology0.89023670
134MP0004043_abnormal_pH_regulation0.88339613
135MP0003121_genomic_imprinting0.88295605
136MP0002269_muscular_atrophy0.88289045
137MP0000432_abnormal_head_morphology0.86878999
138MP0009250_abnormal_appendicular_skeleto0.86656042
139MP0005076_abnormal_cell_differentiation0.86272296
140MP0010678_abnormal_skin_adnexa0.85860125
141MP0005621_abnormal_cell_physiology0.85529609
142MP0008932_abnormal_embryonic_tissue0.85100927
143MP0000462_abnormal_digestive_system0.84385050
144MP0000747_muscle_weakness0.84345516
145MP0002697_abnormal_eye_size0.84152380
146MP0001879_abnormal_lymphatic_vessel0.83989139
147MP0000350_abnormal_cell_proliferation0.83769165
148MP0000467_abnormal_esophagus_morphology0.83428537
149MP0002233_abnormal_nose_morphology0.83061053
150MP0001270_distended_abdomen0.83039896
151MP0001340_abnormal_eyelid_morphology0.82100242
152MP0001299_abnormal_eye_distance/0.81561976
153MP0002090_abnormal_vision0.81435315
154MP0005023_abnormal_wound_healing0.81078517
155MP0005508_abnormal_skeleton_morphology0.80845322
156MP0001672_abnormal_embryogenesis/_devel0.80626008
157MP0005380_embryogenesis_phenotype0.80626008
158MP0003984_embryonic_growth_retardation0.80021926
159MP0002092_abnormal_eye_morphology0.79067937
160MP0002078_abnormal_glucose_homeostasis0.78767608
161MP0005187_abnormal_penis_morphology0.78726543
162MP0003890_abnormal_embryonic-extraembry0.77671940
163MP0010368_abnormal_lymphatic_system0.77665786
164MP0002086_abnormal_extraembryonic_tissu0.77118226
165MP0002088_abnormal_embryonic_growth/wei0.76312859
166MP0001243_abnormal_dermal_layer0.76077292
167MP0005645_abnormal_hypothalamus_physiol0.75604081
168MP0003111_abnormal_nucleus_morphology0.75282376
169MP0002081_perinatal_lethality0.73815010
170MP0001216_abnormal_epidermal_layer0.73767492
171MP0002557_abnormal_social/conspecific_i0.72488973
172MP0002896_abnormal_bone_mineralization0.72385965
173MP0003632_abnormal_nervous_system0.71785583
174MP0004484_altered_response_of0.69647577
175MP0005375_adipose_tissue_phenotype0.68964265
176MP0002109_abnormal_limb_morphology0.67948026
177MP0009840_abnormal_foam_cell0.67496115
178MP0001765_abnormal_ion_homeostasis0.67091557
179MP0002069_abnormal_eating/drinking_beha0.66492509
180MP0005166_decreased_susceptibility_to0.66062991
181MP0005319_abnormal_enzyme/_coenzyme0.66012232
182MP0004510_myositis0.65981516
183MP0002882_abnormal_neuron_morphology0.64367429
184MP0003634_abnormal_glial_cell0.61327330

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.33593242
2Deep venous thrombosis (HP:0002625)4.26255420
3Atrophic scars (HP:0001075)4.25835824
4Premature rupture of membranes (HP:0001788)4.14401572
5Cerebral inclusion bodies (HP:0100314)3.75351553
6Neurofibrillary tangles (HP:0002185)3.44287999
7Focal motor seizures (HP:0011153)3.38247061
8Vascular tortuosity (HP:0004948)3.35380961
9Intrahepatic cholestasis (HP:0001406)3.32153059
10Aortic dissection (HP:0002647)3.30434729
11Arterial tortuosity (HP:0005116)3.29420690
12Visual hallucinations (HP:0002367)3.22516529
13Papillary thyroid carcinoma (HP:0002895)3.19221623
14Supranuclear gaze palsy (HP:0000605)3.18709703
15Myokymia (HP:0002411)3.08033858
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.07819039
17Termporal pattern (HP:0011008)2.99727980
18Insidious onset (HP:0003587)2.99727980
19Xanthomatosis (HP:0000991)2.99127177
20Focal seizures (HP:0007359)2.96339426
21Fragile skin (HP:0001030)2.95448753
22Hyperventilation (HP:0002883)2.93311104
23Complement deficiency (HP:0004431)2.93148602
24Papilledema (HP:0001085)2.86071017
25Ankle contracture (HP:0006466)2.84083447
26Back pain (HP:0003418)2.82070824
27Atonic seizures (HP:0010819)2.78885443
28Absence seizures (HP:0002121)2.77616506
29Asymmetry of the thorax (HP:0001555)2.65214537
30Aortic aneurysm (HP:0004942)2.54223356
31Ketoacidosis (HP:0001993)2.53960816
32Bladder diverticulum (HP:0000015)2.53008009
33Epidermoid cyst (HP:0200040)2.52987597
34Soft skin (HP:0000977)2.51319269
35Ketosis (HP:0001946)2.49822622
36Bowel diverticulosis (HP:0005222)2.48181848
37Intention tremor (HP:0002080)2.47243198
38Wormian bones (HP:0002645)2.47218395
39Hyperlipoproteinemia (HP:0010980)2.47144475
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.46988663
41Action tremor (HP:0002345)2.45408955
42Hypobetalipoproteinemia (HP:0003563)2.44595163
43Mitral stenosis (HP:0001718)2.43570458
44Pheochromocytoma (HP:0002666)2.42313306
45Abnormality of the corticospinal tract (HP:0002492)2.37729255
46Neonatal short-limb short stature (HP:0008921)2.34012448
47Abnormality of the common coagulation pathway (HP:0010990)2.29963788
48Milia (HP:0001056)2.29641415
49Epileptic encephalopathy (HP:0200134)2.29171627
50Dialeptic seizures (HP:0011146)2.28051302
51Impaired vibration sensation in the lower limbs (HP:0002166)2.27540608
52Cerebral hemorrhage (HP:0001342)2.27104412
53Abnormality of the lower motor neuron (HP:0002366)2.24185970
54Relative macrocephaly (HP:0004482)2.23075735
55Impaired social interactions (HP:0000735)2.22854910
56Abnormal social behavior (HP:0012433)2.22854910
57Macroorchidism (HP:0000053)2.22528932
58Generalized tonic-clonic seizures (HP:0002069)2.22160505
59Vertebral arch anomaly (HP:0008438)2.21847636
60Abnormality of the Achilles tendon (HP:0005109)2.21522699
61Postural instability (HP:0002172)2.20533535
62Dysmetria (HP:0001310)2.18789498
63Entropion (HP:0000621)2.18769379
64Excessive salivation (HP:0003781)2.17109631
65Drooling (HP:0002307)2.17109631
66Abnormality of the hip-girdle musculature (HP:0001445)2.16068659
67Abnormality of the musculature of the pelvis (HP:0001469)2.16068659
68Prolonged partial thromboplastin time (HP:0003645)2.15686340
69Breech presentation (HP:0001623)2.14040525
70Abnormality of dentin (HP:0010299)2.13878287
71Lower limb muscle weakness (HP:0007340)2.13369343
72Delayed CNS myelination (HP:0002188)2.11440816
73Broad palm (HP:0001169)2.11154526
74Mitral valve prolapse (HP:0001634)2.11081251
75Heterotopia (HP:0002282)2.10017941
76Limb-girdle muscle weakness (HP:0003325)2.09797561
77Mild short stature (HP:0003502)2.09665850
78Long clavicles (HP:0000890)2.05958826
79Urinary urgency (HP:0000012)2.04085771
80Skin nodule (HP:0200036)2.04085257
81Poor eye contact (HP:0000817)2.03244266
82Spinal rigidity (HP:0003306)2.02280086
83Buphthalmos (HP:0000557)2.02047015
84Cortical dysplasia (HP:0002539)2.02026387
85Scanning speech (HP:0002168)2.01474087
86Abnormality of the calcaneus (HP:0008364)2.01379003
87Dysdiadochokinesis (HP:0002075)2.00870899
88Agitation (HP:0000713)1.99873571
89Torticollis (HP:0000473)1.97960568
90Thyroid carcinoma (HP:0002890)1.97335342
91Pelvic girdle muscle weakness (HP:0003749)1.97110482
92Epileptiform EEG discharges (HP:0011182)1.96673458
93EEG with generalized epileptiform discharges (HP:0011198)1.96286127
94Spontaneous abortion (HP:0005268)1.95336002
95Ankyloglossia (HP:0010296)1.94874573
96Rhizomelia (HP:0008905)1.93951607
97Depression (HP:0000716)1.93880699
98Status epilepticus (HP:0002133)1.93443764
99Overgrowth (HP:0001548)1.93109662
100Neonatal onset (HP:0003623)1.93012962
101Shoulder girdle muscle weakness (HP:0003547)1.93004226
102Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92593522
103Natal tooth (HP:0000695)1.92140305
104Anxiety (HP:0000739)1.91310685
105Neuroendocrine neoplasm (HP:0100634)1.90812645
106Truncal ataxia (HP:0002078)1.90632305
107Achilles tendon contracture (HP:0001771)1.90387029
108Abnormality of complement system (HP:0005339)1.90045215
109Hypsarrhythmia (HP:0002521)1.89050511
110Spastic diplegia (HP:0001264)1.88868143
111Abnormal gallbladder physiology (HP:0012438)1.88735534
112Cholecystitis (HP:0001082)1.88735534
113Joint laxity (HP:0001388)1.88339686
114Amblyopia (HP:0000646)1.87726753
115Abnormality of glutamine family amino acid metabolism (HP:0010902)1.87431827
116Knee flexion contracture (HP:0006380)1.87431513
117Subacute progressive viral hepatitis (HP:0006572)1.87372901
118Aplasia cutis congenita (HP:0001057)1.87189870
119Hypolipoproteinemia (HP:0010981)1.87089195
120Global brain atrophy (HP:0002283)1.86208415
121Cubitus valgus (HP:0002967)1.86058805
122Dilatation of the ascending aorta (HP:0005111)1.86052453
123Onycholysis (HP:0001806)1.86025895
124Resting tremor (HP:0002322)1.85446367
125Type 1 muscle fiber predominance (HP:0003803)1.84855079
126Abnormal foot bone ossification (HP:0010675)1.84512309
127Spastic gait (HP:0002064)1.83847620
128Progressive cerebellar ataxia (HP:0002073)1.82722248
129Ankle clonus (HP:0011448)1.82693748
130Hyperammonemia (HP:0001987)1.82267172
131Fragile nails (HP:0001808)1.81718414
132Syringomyelia (HP:0003396)1.79207592
133Spinal cord lesions (HP:0100561)1.79207592
134Gout (HP:0001997)1.78526725
135Hypoplastic nipples (HP:0002557)1.77691539
136Hemiplegia (HP:0002301)1.77524503
137Abnormality of the phalanges of the hallux (HP:0010057)1.76689262
138Broad-based gait (HP:0002136)1.75799259
139Sensorimotor neuropathy (HP:0007141)1.75539973
140Striae distensae (HP:0001065)1.75371637
141Degeneration of the lateral corticospinal tracts (HP:0002314)1.74700991
142Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74700991
143Mildly elevated creatine phosphokinase (HP:0008180)1.74667853
144Hypoplasia of the iris (HP:0007676)1.74584748
145Generalized myoclonic seizures (HP:0002123)1.74410190
146Abnormality of the intrinsic pathway (HP:0010989)1.74341352
147Cutaneous melanoma (HP:0012056)1.74317596
148Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.74253866
149Hypoalphalipoproteinemia (HP:0003233)1.74198724
150Rapidly progressive (HP:0003678)1.73486306
151Calcaneovalgus deformity (HP:0001848)1.73270461
152Limb-girdle muscle atrophy (HP:0003797)1.73075420
153Ulnar bowing (HP:0003031)1.72221417
154Mesomelia (HP:0003027)1.72186363
155Decreased skull ossification (HP:0004331)1.71984800
156Craniofacial dystonia (HP:0012179)1.71536203
157Facial hemangioma (HP:0000329)1.71524001
158Follicular hyperkeratosis (HP:0007502)1.71174339
159Hypercortisolism (HP:0001578)1.69790951
160Dysmetric saccades (HP:0000641)1.69655725
161Abnormal delivery (HP:0001787)1.69476558
162Urinary bladder sphincter dysfunction (HP:0002839)1.69134625
163Complete atrioventricular canal defect (HP:0001674)1.69109141
164Akinesia (HP:0002304)1.69078096
165Focal dystonia (HP:0004373)1.68543429
166Abnormality of skull ossification (HP:0002703)1.68319449
167Lymphangioma (HP:0100764)1.68310360
168Hammertoe (HP:0001765)1.67701900
169Lower limb amyotrophy (HP:0007210)1.67701279
170Poikiloderma (HP:0001029)1.67520614
171Neuronal loss in central nervous system (HP:0002529)1.66853401
172Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66783559
173Osteolytic defects of the phalanges of the hand (HP:0009771)1.65786081
174Osteolytic defects of the hand bones (HP:0009699)1.65786081
175Aneurysm (HP:0002617)1.65498193
176Abnormality of the acetabulum (HP:0003170)1.65141848
177Overlapping toe (HP:0001845)1.65008627
178Autoamputation (HP:0001218)1.64959968
179Spondylolisthesis (HP:0003302)1.63636828
180Volvulus (HP:0002580)1.61722854
181Capillary hemangiomas (HP:0005306)1.61307576
182Flat acetabular roof (HP:0003180)1.61146943
183Metatarsus adductus (HP:0001840)1.60181467
184Wide anterior fontanel (HP:0000260)1.59616975
185Large earlobe (HP:0009748)1.59272066
186Shallow orbits (HP:0000586)1.56479890
187Hyperextensible skin (HP:0000974)1.55910625
188Cystic hygroma (HP:0000476)1.54774458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.49316051
2NTRK32.89991378
3AKT32.85151305
4NEK92.69704400
5EPHA42.66978104
6MAP3K42.54101273
7MAP2K42.47939749
8MINK12.34128010
9MARK12.25530537
10KSR22.24440418
11ERBB32.18796291
12BRD41.99577188
13PKN21.98897070
14RIPK41.97247126
15EIF2AK31.97013526
16NTRK11.95796516
17RIPK11.81087029
18PRKD31.79421153
19DAPK21.75277762
20RET1.71104944
21MAP3K21.62359268
22PAK61.61447507
23EEF2K1.60603183
24MAP3K131.58702184
25MAP3K121.57890609
26FGFR21.56180801
27PNCK1.52931536
28SCYL21.48822664
29TTN1.48662999
30BRSK21.45608265
31CAMKK11.45097953
32RAF11.42949086
33ICK1.38597423
34CDK121.36245747
35FRK1.35644267
36SRPK11.33312443
37TRIB31.31339827
38KSR11.31239771
39PAK31.30166320
40CLK11.25923543
41PAK21.23415011
42CAMK1G1.22745068
43EPHB21.21363989
44SIK21.19078450
45PLK21.18732369
46LATS21.18049717
47PRKCH1.17907598
48MAP2K71.16035299
49CDK51.13145388
50CDK61.09690171
51FER1.08712930
52WNK41.06392587
53OXSR11.05701298
54FLT31.05093028
55SIK10.98780060
56DAPK10.96595094
57NEK20.96298390
58MAP3K70.95119045
59STK38L0.92804157
60WNK10.92154473
61STK390.90866764
62PTK60.90858244
63CASK0.90665291
64TRPM70.90323712
65PIK3CA0.90213451
66STK110.90212435
67MAP3K100.90172017
68PTK2B0.87568769
69PBK0.85726783
70ERN10.85084800
71PDGFRA0.84751000
72MAP3K10.84438534
73FGFR40.84413592
74MKNK10.83819543
75RPS6KB10.83620292
76ALK0.82568711
77CSNK1G20.79015976
78TTK0.78773942
79CDK30.78453644
80FES0.77801201
81TYRO30.77670592
82PDK10.77002501
83FGFR30.76896635
84PDPK10.76217686
85SGK20.76100722
86WEE10.73627955
87GRK60.72610522
88PDK40.72520873
89PDK30.72520873
90PTK20.72408556
91BCR0.72018090
92MYLK0.71476763
93CAMKK20.71101031
94TAOK10.69468216
95SGK30.68777863
96MAP3K60.68275892
97PRKCG0.68047205
98MAP2K10.67759738
99CAMK2A0.66912263
100FGR0.66184246
101ROCK20.65277025
102MST1R0.64405918
103LIMK10.63642876
104MAPKAPK50.63095356
105NEK10.61896437
106PIK3CG0.61731912
107GRK50.61729893
108CDK140.61068751
109DDR20.60812376
110STK380.60084336
111PRKCZ0.59627400
112CDK190.57795355
113FYN0.57350864
114CSNK1A1L0.56975291
115TSSK60.56715086
116RPS6KB20.56683254
117CDC70.55899583
118MET0.55458480
119SGK10.55379330
120MAPK120.54326126
121UHMK10.51065339
122ATM0.50754567
123MAP3K50.50526752
124ERBB40.50124227
125MAPK100.49924877
126DMPK0.49746268
127JAK10.49640981
128PDGFRB0.49596572
129CSF1R0.49026847
130CCNB10.48871543
131CHEK10.48821283
132CAMK2B0.48728827
133PRKCQ0.48138699
134PHKG20.47414789
135PHKG10.47414789
136SGK2230.47112891
137SGK4940.47112891
138PLK10.46839508
139CDK11A0.46705645
140INSRR0.46602446
141CDK150.46381326
142MELK0.45909507
143CDK180.45909385
144PRKCE0.45207933
145CSNK1E0.45180316
146EPHB10.44877053
147LATS10.44698510
148MTOR0.42407382
149MAP3K140.42007900
150STK30.40983878
151CDK90.40819496
152BRSK10.40440083
153PAK40.39660074

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.99967219
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81987491
3ECM-receptor interaction_Homo sapiens_hsa045122.28030209
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.27188157
5Non-homologous end-joining_Homo sapiens_hsa034502.15828297
6Arginine biosynthesis_Homo sapiens_hsa002202.05885813
7Focal adhesion_Homo sapiens_hsa045102.00859205
8Small cell lung cancer_Homo sapiens_hsa052221.98435072
9Long-term potentiation_Homo sapiens_hsa047201.89405365
10Butanoate metabolism_Homo sapiens_hsa006501.66673023
11Chronic myeloid leukemia_Homo sapiens_hsa052201.66645770
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63236321
13Adherens junction_Homo sapiens_hsa045201.61867207
14Synaptic vesicle cycle_Homo sapiens_hsa047211.60229528
15Pancreatic cancer_Homo sapiens_hsa052121.59922475
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57238642
17Nicotine addiction_Homo sapiens_hsa050331.55176692
18Amphetamine addiction_Homo sapiens_hsa050311.52039834
19GABAergic synapse_Homo sapiens_hsa047271.51694306
20Bile secretion_Homo sapiens_hsa049761.50928561
21Circadian entrainment_Homo sapiens_hsa047131.50694354
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49469244
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47200329
24Cell cycle_Homo sapiens_hsa041101.44786029
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44589710
26Endometrial cancer_Homo sapiens_hsa052131.43548289
27MicroRNAs in cancer_Homo sapiens_hsa052061.43235562
28Glutamatergic synapse_Homo sapiens_hsa047241.42054786
29Nucleotide excision repair_Homo sapiens_hsa034201.41680969
30Proteoglycans in cancer_Homo sapiens_hsa052051.41261592
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40509133
32Dopaminergic synapse_Homo sapiens_hsa047281.38855102
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38483715
34mRNA surveillance pathway_Homo sapiens_hsa030151.37985465
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35557330
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34784036
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33344469
38Renin secretion_Homo sapiens_hsa049241.33282991
39Salivary secretion_Homo sapiens_hsa049701.31892101
40Colorectal cancer_Homo sapiens_hsa052101.31854241
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.31795319
42Complement and coagulation cascades_Homo sapiens_hsa046101.30922512
43Sulfur metabolism_Homo sapiens_hsa009201.29802168
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27852485
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25234397
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24982473
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24712609
48Morphine addiction_Homo sapiens_hsa050321.23834936
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23778824
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23111029
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22167990
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21897984
53Amoebiasis_Homo sapiens_hsa051461.20540382
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18858942
55Tryptophan metabolism_Homo sapiens_hsa003801.18480067
56Inositol phosphate metabolism_Homo sapiens_hsa005621.17947885
57Insulin secretion_Homo sapiens_hsa049111.17515632
58Thyroid cancer_Homo sapiens_hsa052161.16434329
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15224246
60TGF-beta signaling pathway_Homo sapiens_hsa043501.15030536
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14595264
62Oocyte meiosis_Homo sapiens_hsa041141.13100871
63Gastric acid secretion_Homo sapiens_hsa049711.12980609
64Long-term depression_Homo sapiens_hsa047301.12036013
65Prolactin signaling pathway_Homo sapiens_hsa049171.11669631
66Olfactory transduction_Homo sapiens_hsa047401.11116139
67Prostate cancer_Homo sapiens_hsa052151.10521190
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09148121
69Hippo signaling pathway_Homo sapiens_hsa043901.09023802
70p53 signaling pathway_Homo sapiens_hsa041151.08866787
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06783742
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05811406
73Cholinergic synapse_Homo sapiens_hsa047251.05492969
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03476240
75Type II diabetes mellitus_Homo sapiens_hsa049301.02258999
76Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00394182
77Oxytocin signaling pathway_Homo sapiens_hsa049210.99769185
78Propanoate metabolism_Homo sapiens_hsa006400.96125345
79Fatty acid degradation_Homo sapiens_hsa000710.95696830
80Glioma_Homo sapiens_hsa052140.95612342
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95581095
82Pathways in cancer_Homo sapiens_hsa052000.94823981
83Cocaine addiction_Homo sapiens_hsa050300.94701372
84FoxO signaling pathway_Homo sapiens_hsa040680.94433095
85PPAR signaling pathway_Homo sapiens_hsa033200.93756750
86Estrogen signaling pathway_Homo sapiens_hsa049150.92914998
87GnRH signaling pathway_Homo sapiens_hsa049120.92835231
88Melanoma_Homo sapiens_hsa052180.92694180
89Pyruvate metabolism_Homo sapiens_hsa006200.87043674
90Bladder cancer_Homo sapiens_hsa052190.86275946
91Protein digestion and absorption_Homo sapiens_hsa049740.86185089
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85244876
93Hedgehog signaling pathway_Homo sapiens_hsa043400.84599580
94Wnt signaling pathway_Homo sapiens_hsa043100.81010276
95Gap junction_Homo sapiens_hsa045400.80786300
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80572011
97Fatty acid metabolism_Homo sapiens_hsa012120.80364253
98Thyroid hormone synthesis_Homo sapiens_hsa049180.78171461
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.77901953
100Serotonergic synapse_Homo sapiens_hsa047260.77519549
101Glucagon signaling pathway_Homo sapiens_hsa049220.75313938
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74956677
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74751161
104Circadian rhythm_Homo sapiens_hsa047100.74541847
105Dorso-ventral axis formation_Homo sapiens_hsa043200.73134791
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70291257
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70044838
108Prion diseases_Homo sapiens_hsa050200.68553409
109Axon guidance_Homo sapiens_hsa043600.67797630
110RNA transport_Homo sapiens_hsa030130.66824731
111ErbB signaling pathway_Homo sapiens_hsa040120.66088951
112cAMP signaling pathway_Homo sapiens_hsa040240.64624410
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.64212972
114Calcium signaling pathway_Homo sapiens_hsa040200.63587308
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62482418
116Histidine metabolism_Homo sapiens_hsa003400.61635760
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60840821
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59462493
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57815259
120Viral carcinogenesis_Homo sapiens_hsa052030.57786085
121Taste transduction_Homo sapiens_hsa047420.57392395
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57246712
123VEGF signaling pathway_Homo sapiens_hsa043700.56152654
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55440744
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55170238
126Steroid biosynthesis_Homo sapiens_hsa001000.54171135
127Peroxisome_Homo sapiens_hsa041460.53918371
128N-Glycan biosynthesis_Homo sapiens_hsa005100.53740296
129Staphylococcus aureus infection_Homo sapiens_hsa051500.53621557
130Phenylalanine metabolism_Homo sapiens_hsa003600.53505328
131Insulin resistance_Homo sapiens_hsa049310.53298559
132mTOR signaling pathway_Homo sapiens_hsa041500.53212662
133Melanogenesis_Homo sapiens_hsa049160.52855276
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52781934
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.52772307
136Vibrio cholerae infection_Homo sapiens_hsa051100.52192604
137Collecting duct acid secretion_Homo sapiens_hsa049660.49567816
138Renal cell carcinoma_Homo sapiens_hsa052110.49490077
139Acute myeloid leukemia_Homo sapiens_hsa052210.49041901
140Basal cell carcinoma_Homo sapiens_hsa052170.47438686
141Insulin signaling pathway_Homo sapiens_hsa049100.47436132
142Endocytosis_Homo sapiens_hsa041440.46483979
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45457730
144Pancreatic secretion_Homo sapiens_hsa049720.45306623
145Dilated cardiomyopathy_Homo sapiens_hsa054140.45151981
146Glycerolipid metabolism_Homo sapiens_hsa005610.44668455
147Starch and sucrose metabolism_Homo sapiens_hsa005000.43593338
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43428622
149ABC transporters_Homo sapiens_hsa020100.43035593
150Choline metabolism in cancer_Homo sapiens_hsa052310.41745492
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.41510162
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.39137312
153Non-small cell lung cancer_Homo sapiens_hsa052230.38621740
154beta-Alanine metabolism_Homo sapiens_hsa004100.37487562
155Platelet activation_Homo sapiens_hsa046110.36820226
156AMPK signaling pathway_Homo sapiens_hsa041520.36504207

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