GORASP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.05717901
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.05717901
3L-phenylalanine metabolic process (GO:0006558)5.96401881
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.96401881
5Golgi transport vesicle coating (GO:0048200)5.09112609
6COPI coating of Golgi vesicle (GO:0048205)5.09112609
7serine family amino acid catabolic process (GO:0009071)4.86764632
8aromatic amino acid family catabolic process (GO:0009074)4.75654184
9glycine metabolic process (GO:0006544)4.63439535
10glyoxylate metabolic process (GO:0046487)4.57033109
11sulfur amino acid catabolic process (GO:0000098)4.28173210
12tryptophan metabolic process (GO:0006568)4.26142797
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.24058726
14kynurenine metabolic process (GO:0070189)4.21300584
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.10504568
16serine family amino acid metabolic process (GO:0009069)4.03197350
17lysine catabolic process (GO:0006554)4.02769431
18lysine metabolic process (GO:0006553)4.02769431
19aromatic amino acid family metabolic process (GO:0009072)4.01159134
20indole-containing compound catabolic process (GO:0042436)3.97355786
21indolalkylamine catabolic process (GO:0046218)3.97355786
22tryptophan catabolic process (GO:0006569)3.97355786
23bile acid biosynthetic process (GO:0006699)3.95083420
24cysteine metabolic process (GO:0006534)3.94320004
25pantothenate metabolic process (GO:0015939)3.91169822
26cellular ketone body metabolic process (GO:0046950)3.82823793
27serine family amino acid biosynthetic process (GO:0009070)3.80241970
28biotin metabolic process (GO:0006768)3.79366320
292-oxoglutarate metabolic process (GO:0006103)3.78777141
30alpha-amino acid catabolic process (GO:1901606)3.75527464
31tyrosine metabolic process (GO:0006570)3.75208108
32branched-chain amino acid catabolic process (GO:0009083)3.71724590
33stress fiber assembly (GO:0043149)3.68562706
34cellular amino acid catabolic process (GO:0009063)3.66275852
35sperm capacitation (GO:0048240)3.64068045
36valine metabolic process (GO:0006573)3.59717419
37homocysteine metabolic process (GO:0050667)3.56112765
38aspartate family amino acid catabolic process (GO:0009068)3.52275007
39S-adenosylmethionine metabolic process (GO:0046500)3.48886905
40negative regulation of fibrinolysis (GO:0051918)3.48301702
41high-density lipoprotein particle remodeling (GO:0034375)3.47790862
42amino-acid betaine metabolic process (GO:0006577)3.46568622
43antigen processing and presentation via MHC class Ib (GO:0002475)3.45976017
44regulation of fibrinolysis (GO:0051917)3.45214072
45branched-chain amino acid metabolic process (GO:0009081)3.43163114
46bile acid metabolic process (GO:0008206)3.40263048
47L-serine metabolic process (GO:0006563)3.39614684
48coenzyme catabolic process (GO:0009109)3.39417190
49cellular modified amino acid catabolic process (GO:0042219)3.37783221
50cytoskeletal anchoring at plasma membrane (GO:0007016)3.36841469
51organic acid catabolic process (GO:0016054)3.34423297
52carboxylic acid catabolic process (GO:0046395)3.34423297
53fatty acid catabolic process (GO:0009062)3.32084316
54protein carboxylation (GO:0018214)3.30444416
55peptidyl-glutamic acid carboxylation (GO:0017187)3.30444416
56protein localization to endosome (GO:0036010)3.30379303
57ketone body metabolic process (GO:1902224)3.29346121
58alpha-linolenic acid metabolic process (GO:0036109)3.29227938
59regulation of protein activation cascade (GO:2000257)3.25788594
60amino acid salvage (GO:0043102)3.25759268
61L-methionine salvage (GO:0071267)3.25759268
62L-methionine biosynthetic process (GO:0071265)3.25759268
63vitamin transmembrane transport (GO:0035461)3.24392844
64NADH metabolic process (GO:0006734)3.23875985
65sexual reproduction (GO:0019953)3.20315959
66urea cycle (GO:0000050)3.20260817
67urea metabolic process (GO:0019627)3.20260817
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.19686709
69blood coagulation, intrinsic pathway (GO:0007597)3.18165757
70monocarboxylic acid catabolic process (GO:0072329)3.17502528
71sulfur amino acid biosynthetic process (GO:0000097)3.14620059
72negative regulation of erythrocyte differentiation (GO:0045647)3.13785723
73fatty acid beta-oxidation (GO:0006635)3.13569159
74mannose metabolic process (GO:0006013)3.11301854
75negative regulation of cholesterol transport (GO:0032375)3.11267646
76negative regulation of sterol transport (GO:0032372)3.11267646
77indolalkylamine metabolic process (GO:0006586)3.10272238
78sulfur amino acid metabolic process (GO:0000096)3.10219126
79cell volume homeostasis (GO:0006884)3.07627847
80short-chain fatty acid metabolic process (GO:0046459)3.07609615
81regulation of oxidative phosphorylation (GO:0002082)3.05717438
82complement activation, alternative pathway (GO:0006957)3.05581641
83glutamate metabolic process (GO:0006536)3.04624451
84regulation of complement activation (GO:0030449)3.04106096
85acetyl-CoA metabolic process (GO:0006084)3.03334716
86fatty acid oxidation (GO:0019395)3.02906080
87regulation of cholesterol metabolic process (GO:0090181)3.01354942
88drug transmembrane transport (GO:0006855)3.00552335
89regulation of cholesterol esterification (GO:0010872)3.00269789
90protein targeting to lysosome (GO:0006622)2.97965848
91establishment of protein localization to vacuole (GO:0072666)2.97965848
92protein targeting to vacuole (GO:0006623)2.97965848
93cell-cell junction maintenance (GO:0045217)2.97928988
94lipid oxidation (GO:0034440)2.95872778
95amine catabolic process (GO:0009310)2.95478429
96cellular biogenic amine catabolic process (GO:0042402)2.95478429
97folic acid metabolic process (GO:0046655)2.95014735
98regulation of triglyceride catabolic process (GO:0010896)2.94661057
99actin filament depolymerization (GO:0030042)2.93807613
100pyrimidine-containing compound transmembrane transport (GO:0072531)2.93145976
101acylglycerol homeostasis (GO:0055090)2.92209961
102triglyceride homeostasis (GO:0070328)2.92209961
103nitrogen cycle metabolic process (GO:0071941)2.91928099
104glucose 6-phosphate metabolic process (GO:0051156)2.91825640
105negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.91728312
106reverse cholesterol transport (GO:0043691)2.91632269
107urate metabolic process (GO:0046415)2.90967742
108heme transport (GO:0015886)2.90101883
109aspartate family amino acid metabolic process (GO:0009066)2.87135283
110bile acid and bile salt transport (GO:0015721)2.84777223
111plasma lipoprotein particle remodeling (GO:0034369)2.83461846
112protein-lipid complex remodeling (GO:0034368)2.83461846
113macromolecular complex remodeling (GO:0034367)2.83461846
114peptidyl-proline hydroxylation (GO:0019511)2.83182193
115regulation of cholesterol biosynthetic process (GO:0045540)2.83083782
116regulation of early endosome to late endosome transport (GO:2000641)2.81896515
117GMP metabolic process (GO:0046037)2.81426466
118small molecule catabolic process (GO:0044282)2.81355521
119cofactor catabolic process (GO:0051187)2.80828283
120tricarboxylic acid metabolic process (GO:0072350)2.78312919
121regulation of ARF protein signal transduction (GO:0032012)2.73807089
122regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.72562754
123negative regulation of insulin receptor signaling pathway (GO:0046627)2.66626584
124protein targeting to plasma membrane (GO:0072661)2.65508522
1254-hydroxyproline metabolic process (GO:0019471)2.64301207
126regulation of T-helper 2 cell differentiation (GO:0045628)2.63884203
127peptide catabolic process (GO:0043171)2.63520251
128positive regulation of lipoprotein lipase activity (GO:0051006)2.61388540
129positive regulation of triglyceride lipase activity (GO:0061365)2.61388540
130vesicle coating (GO:0006901)2.55125384
131barbed-end actin filament capping (GO:0051016)2.53870282
132regulation of ARF GTPase activity (GO:0032312)2.53553727
133COPII vesicle coating (GO:0048208)2.52329954
134intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.52089947
135microtubule severing (GO:0051013)2.50222188
136adhesion of symbiont to host cell (GO:0044650)2.48587823
137virion attachment to host cell (GO:0019062)2.48587823
138regulation of autophagic vacuole assembly (GO:2000785)2.47693099
139regulation of histone H3-K27 methylation (GO:0061085)2.47370009
140establishment of endothelial barrier (GO:0061028)2.47138870
141negative regulation of cellular response to insulin stimulus (GO:1900077)2.45423120
142adhesion of symbiont to host (GO:0044406)2.43541446
143positive regulation of type 2 immune response (GO:0002830)2.43069292
144negative regulation of Rho protein signal transduction (GO:0035024)2.41914985
145regulation of insulin receptor signaling pathway (GO:0046626)2.39780923
146amyloid precursor protein catabolic process (GO:0042987)2.39503378
147membrane protein ectodomain proteolysis (GO:0006509)2.38159191
148epithelial cell-cell adhesion (GO:0090136)2.36283852
149regulation of Rho protein signal transduction (GO:0035023)2.36131539
150cardiolipin metabolic process (GO:0032048)2.36131130
151embryonic process involved in female pregnancy (GO:0060136)2.35648498
152peptidyl-lysine dimethylation (GO:0018027)2.31283380
153protein retention in ER lumen (GO:0006621)2.30042440
154basement membrane organization (GO:0071711)2.29923927
155cell junction maintenance (GO:0034331)2.29307674
156regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.27274827
157membrane budding (GO:0006900)2.25019187
158Rap protein signal transduction (GO:0032486)2.24136273
159negative regulation of glycogen biosynthetic process (GO:0045719)2.24028047
160positive regulation of receptor recycling (GO:0001921)2.22637230
161regulation of mononuclear cell migration (GO:0071675)2.22555024
162pinocytosis (GO:0006907)2.21897678
163positive regulation of Rap GTPase activity (GO:0032854)2.20172989
164eosinophil chemotaxis (GO:0048245)2.20103928
165localization within membrane (GO:0051668)2.19692074
166response to thyroid hormone (GO:0097066)2.19415904
167fusion of sperm to egg plasma membrane (GO:0007342)2.19128155
168activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.18944194
169negative regulation of inclusion body assembly (GO:0090084)2.16581695
170regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.16548101
171negative regulation of T cell receptor signaling pathway (GO:0050860)2.15788383
172regulation of vacuole organization (GO:0044088)2.14860991
173apoptotic cell clearance (GO:0043277)2.14717730
174positive regulation of cellular amide metabolic process (GO:0034250)2.14143762
175maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.13363751
176positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.12890619
177sodium ion export (GO:0071436)2.12490703
178purine deoxyribonucleotide catabolic process (GO:0009155)2.12462611
179regulation of cellular amide metabolic process (GO:0034248)2.12114085
180regulation of cellular response to insulin stimulus (GO:1900076)2.12033133
181protein hydroxylation (GO:0018126)2.11833536
182receptor recycling (GO:0001881)2.10833230
183negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.10771671
184sphingomyelin metabolic process (GO:0006684)2.10110848
185cellular response to thyroid hormone stimulus (GO:0097067)2.08208631
186retrograde transport, endosome to Golgi (GO:0042147)2.07361003
187regulation of amyloid precursor protein catabolic process (GO:1902991)2.07172592
188skin morphogenesis (GO:0043589)2.06080539
189regulation of clathrin-mediated endocytosis (GO:2000369)2.05457091
190protein depolymerization (GO:0051261)2.05402894
191response to acidic pH (GO:0010447)2.05330388
192ruffle organization (GO:0031529)2.05080625
193regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.04950245
194membrane protein intracellular domain proteolysis (GO:0031293)2.04427258
195regulation of inclusion body assembly (GO:0090083)2.04258465
196glomerular basement membrane development (GO:0032836)2.03965431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.32240214
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.79934412
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.21364511
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.14827598
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.65593309
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.47057198
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.41430697
8* LXR_22158963_ChIP-Seq_LIVER_Mouse3.25562112
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.20622235
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.93775185
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.79017794
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70964169
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62933590
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.38482388
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32167369
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.31779205
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27640519
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25907701
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.19271048
20ZNF263_19887448_ChIP-Seq_K562_Human2.17387344
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.10423107
22RACK7_27058665_Chip-Seq_MCF-7_Human2.08041700
23* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06872547
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02212542
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.01637104
26* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98547488
27* MYC_18555785_ChIP-Seq_MESCs_Mouse1.98200679
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95482139
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93661928
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91974967
31* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91471631
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.90290211
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88031635
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83502668
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83299279
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.83206550
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81919504
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81761547
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76378411
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70998764
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70484520
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69417152
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67724728
44KDM2B_26808549_Chip-Seq_K562_Human1.63261084
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62656240
46* SMC4_20622854_ChIP-Seq_HELA_Human1.62053869
47* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61910869
48KDM2B_26808549_Chip-Seq_DND41_Human1.61351446
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.59936595
50* TCF7_22412390_ChIP-Seq_EML_Mouse1.56814965
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.56615821
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.47205456
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46025960
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45649000
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44743401
56GATA1_19941826_ChIP-Seq_K562_Human1.44502574
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.44278546
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44124797
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43157461
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.40883314
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40643368
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39990236
63VDR_21846776_ChIP-Seq_THP-1_Human1.39738644
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.39320926
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39160716
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37973736
67GABP_19822575_ChIP-Seq_HepG2_Human1.37193900
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36626502
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35175193
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33226950
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33004094
72VDR_24763502_ChIP-Seq_THP-1_Human1.31401371
73SPI1_23127762_ChIP-Seq_K562_Human1.30445342
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.30085142
75DCP1A_22483619_ChIP-Seq_HELA_Human1.30052441
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29726873
77* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28902447
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28748596
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28741111
80* TET1_21490601_ChIP-Seq_MESCs_Mouse1.27461618
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25203000
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.23516783
83* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21520723
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21282309
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20861622
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20282969
87TP63_22573176_ChIP-Seq_HFKS_Human1.19764306
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19545112
89MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19361861
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19288076
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.18404242
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18276232
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.18232459
94DROSHA_22980978_ChIP-Seq_HELA_Human1.17659637
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17215547
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16941859
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.16108867
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.16108867
99IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15097205
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14907417
101BCL6_27268052_Chip-Seq_Bcells_Human1.14493890
102RUNX1_22412390_ChIP-Seq_EML_Mouse1.13814688
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13552455
104PHF8_20622854_ChIP-Seq_HELA_Human1.13439202
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.13358145
106XRN2_22483619_ChIP-Seq_HELA_Human1.13071492
107CLOCK_20551151_ChIP-Seq_293T_Human1.12928216
108SRF_21415370_ChIP-Seq_HL-1_Mouse1.11993374
109JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11648335
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10916484
111KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10793241
112ATF3_27146783_Chip-Seq_COLON_Human1.10457831
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09166555
114CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08963663
115NCOR1_26117541_ChIP-Seq_K562_Human1.08708064
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06676127
117FOXP1_21924763_ChIP-Seq_HESCs_Human1.06615151
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06536354
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.06480466
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.06417805
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05775056
122* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05507233
123TP53_22127205_ChIP-Seq_IMR90_Human1.05478652
124CREB1_26743006_Chip-Seq_LNCaP_Human1.05444791
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04863163
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03596991
127TRIM28_21343339_ChIP-Seq_HEK293_Human1.03582486
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03061691
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02195546
130MYC_22102868_ChIP-Seq_BL_Human1.02072596
131SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02040790
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01370379
133HTT_18923047_ChIP-ChIP_STHdh_Human1.01218268
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98567218
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97544326
136GATA1_22025678_ChIP-Seq_K562_Human0.97514602
137CTCF_27219007_Chip-Seq_Bcells_Human0.96224071
138SA1_27219007_Chip-Seq_Bcells_Human0.95820768
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94051347
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93137691
141SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92710074
142P68_20966046_ChIP-Seq_HELA_Human0.92496738
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90766994
144IRF1_19129219_ChIP-ChIP_H3396_Human0.90689224
145TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90009885
146STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86576737
147RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86260177
148* LXR_22292898_ChIP-Seq_THP-1_Human0.85065295
149ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84988904
150ERA_21632823_ChIP-Seq_H3396_Human0.84604397
151BCOR_27268052_Chip-Seq_Bcells_Human0.84598390
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83658353
153RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83556286
154TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83496809
155PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82880540
156KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82378444
157NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82360852
158SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81670677
159FOXP3_21729870_ChIP-Seq_TREG_Human0.80122125
160TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78823320
161CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78598088
162MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78318905
163SA1_27219007_Chip-Seq_ERYTHROID_Human0.78030023
164ZNF274_21170338_ChIP-Seq_K562_Hela0.77996849
165RARB_24833708_ChIP-Seq_LIVER_Mouse0.77744789
166EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75431914
167MYCN_18555785_ChIP-Seq_MESCs_Mouse0.75226624
168OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75167090
169E2F1_20622854_ChIP-Seq_HELA_Human0.75068028
170SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74686861
171PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74644571
172HNF4A_19822575_ChIP-Seq_HepG2_Human0.73827271
173CTCF_20526341_ChIP-Seq_ESCs_Human0.73584838
174P53_21459846_ChIP-Seq_SAOS-2_Human0.70436928
175VDR_23849224_ChIP-Seq_CD4+_Human0.70281844
176CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.70148184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.98710366
2MP0005360_urolithiasis5.08313490
3MP0005365_abnormal_bile_salt4.96693338
4MP0005085_abnormal_gallbladder_physiolo4.81168671
5MP0000569_abnormal_digit_pigmentation4.39784981
6MP0009840_abnormal_foam_cell4.10180440
7MP0003172_abnormal_lysosome_physiology3.97797930
8MP0008875_abnormal_xenobiotic_pharmacok3.71998532
9MP0003303_peritoneal_inflammation3.40939761
10MP0005083_abnormal_biliary_tract3.16483893
11MP0003806_abnormal_nucleotide_metabolis2.99583947
12MP0001666_abnormal_nutrient_absorption2.94833453
13MP0003566_abnormal_cell_adhesion2.70148984
14MP0002837_dystrophic_cardiac_calcinosis2.69428160
15MP0005332_abnormal_amino_acid2.68747029
16MP0010329_abnormal_lipoprotein_level2.55413294
17MP0000015_abnormal_ear_pigmentation2.54712116
18MP0003705_abnormal_hypodermis_morpholog2.36559552
19MP0001958_emphysema2.25876974
20MP0003252_abnormal_bile_duct2.19685370
21MP0006082_CNS_inflammation2.06129791
22MP0003195_calcinosis2.04770308
23MP0006036_abnormal_mitochondrial_physio2.03424296
24MP0004858_abnormal_nervous_system1.98242592
25MP0002118_abnormal_lipid_homeostasis1.90591379
26MP0009697_abnormal_copulation1.88328492
27MP0004019_abnormal_vitamin_homeostasis1.84595235
28MP0003091_abnormal_cell_migration1.80075252
29MP0008438_abnormal_cutaneous_collagen1.73472550
30MP0003868_abnormal_feces_composition1.70533089
31MP0005220_abnormal_exocrine_pancreas1.70036506
32MP0003656_abnormal_erythrocyte_physiolo1.67301613
33MP0000609_abnormal_liver_physiology1.65140854
34MP0003279_aneurysm1.60166021
35MP0005410_abnormal_fertilization1.57792269
36MP0003453_abnormal_keratinocyte_physiol1.57447755
37MP0005319_abnormal_enzyme/_coenzyme1.52963443
38MP0004233_abnormal_muscle_weight1.50106257
39MP0000467_abnormal_esophagus_morphology1.48489945
40MP0010234_abnormal_vibrissa_follicle1.48285785
41MP0005451_abnormal_body_composition1.47371551
42MP0004043_abnormal_pH_regulation1.46987041
43MP0002877_abnormal_melanocyte_morpholog1.46215235
44MP0005636_abnormal_mineral_homeostasis1.44796908
45MP0001764_abnormal_homeostasis1.44143834
46MP0005408_hypopigmentation1.41375586
47MP0005464_abnormal_platelet_physiology1.39843304
48MP0003724_increased_susceptibility_to1.38974713
49MP0006035_abnormal_mitochondrial_morpho1.37433112
50MP0008961_abnormal_basal_metabolism1.36198083
51MP0003436_decreased_susceptibility_to1.35605296
52MP0009643_abnormal_urine_homeostasis1.34066426
53MP0000678_abnormal_parathyroid_gland1.33677260
54MP0005670_abnormal_white_adipose1.32306668
55MP0003690_abnormal_glial_cell1.31969643
56MP0003879_abnormal_hair_cell1.30896157
57MP0000747_muscle_weakness1.30248827
58MP0002998_abnormal_bone_remodeling1.28554652
59MP0005409_darkened_coat_color1.28240687
60MP0009379_abnormal_foot_pigmentation1.27452917
61MP0002295_abnormal_pulmonary_circulatio1.26382668
62MP0003123_paternal_imprinting1.24480358
63MP0003329_amyloid_beta_deposits1.23377841
64MP0004264_abnormal_extraembryonic_tissu1.23274167
65MP0002254_reproductive_system_inflammat1.23267755
66MP0001849_ear_inflammation1.23042369
67MP0003191_abnormal_cellular_cholesterol1.22476481
68MP0003300_gastrointestinal_ulcer1.22137963
69MP0001545_abnormal_hematopoietic_system1.20667040
70MP0005397_hematopoietic_system_phenotyp1.20667040
71MP0002078_abnormal_glucose_homeostasis1.19926079
72MP0001661_extended_life_span1.19423962
73MP0002909_abnormal_adrenal_gland1.18797568
74MP0001944_abnormal_pancreas_morphology1.17081731
75MP0005584_abnormal_enzyme/coenzyme_acti1.16731044
76MP0002638_abnormal_pupillary_reflex1.15380857
77MP0000751_myopathy1.15060592
78MP0005166_decreased_susceptibility_to1.13367680
79MP0004036_abnormal_muscle_relaxation1.13050875
80MP0005330_cardiomyopathy1.12496339
81MP0005623_abnormal_meninges_morphology1.12014700
82MP0000858_altered_metastatic_potential1.11974535
83MP0001533_abnormal_skeleton_physiology1.10008844
84MP0004947_skin_inflammation1.09931930
85MP0005058_abnormal_lysosome_morphology1.09099894
86MP0001765_abnormal_ion_homeostasis1.08643899
87MP0005174_abnormal_tail_pigmentation1.07392120
88MP0003186_abnormal_redox_activity1.05814427
89MP0005257_abnormal_intraocular_pressure1.03514548
90MP0002269_muscular_atrophy1.02421047
91MP0001756_abnormal_urination1.02216442
92MP0009780_abnormal_chondrocyte_physiolo1.01603432
93MP0003718_maternal_effect1.01209387
94MP0001348_abnormal_lacrimal_gland0.99294708
95MP0003878_abnormal_ear_physiology0.98818789
96MP0005377_hearing/vestibular/ear_phenot0.98818789
97MP0005084_abnormal_gallbladder_morpholo0.98450027
98MP0003828_pulmonary_edema0.97643786
99MP0002971_abnormal_brown_adipose0.97574824
100MP0000249_abnormal_blood_vessel0.96462172
101MP0005666_abnormal_adipose_tissue0.95633713
102MP0000343_altered_response_to0.95438860
103MP0003075_altered_response_to0.95100743
104MP0003183_abnormal_peptide_metabolism0.95044173
105MP0003221_abnormal_cardiomyocyte_apopto0.94392233
106MP0003011_delayed_dark_adaptation0.93207118
107MP0000371_diluted_coat_color0.92371681
108MP0004510_myositis0.91805859
109MP0000013_abnormal_adipose_tissue0.91369009
110MP0005501_abnormal_skin_physiology0.91227306
111MP0005023_abnormal_wound_healing0.89792606
112MP0005535_abnormal_body_temperature0.89515289
113MP0004215_abnormal_myocardial_fiber0.89230113
114MP0005379_endocrine/exocrine_gland_phen0.88898986
115MP0002419_abnormal_innate_immunity0.88296082
116MP0004185_abnormal_adipocyte_glucose0.86623961
117MP0000920_abnormal_myelination0.85646447
118MP0009672_abnormal_birth_weight0.84659398
119MP0000230_abnormal_systemic_arterial0.83996480
120MP0003638_abnormal_response/metabolism_0.83863065
121MP0003137_abnormal_impulse_conducting0.83859661
122MP0005025_abnormal_response_to0.82905261
123MP0001529_abnormal_vocalization0.82676908
124MP0008260_abnormal_autophagy0.82162445
125MP0004859_abnormal_synaptic_plasticity0.81795359
126MP0009115_abnormal_fat_cell0.79958721
127MP0004145_abnormal_muscle_electrophysio0.79231566
128MP0003646_muscle_fatigue0.78935229
129MP0000598_abnormal_liver_morphology0.78306212
130MP0004084_abnormal_cardiac_muscle0.78117416
131MP0009278_abnormal_bone_marrow0.75599257
132MP0009642_abnormal_blood_homeostasis0.75568988
133MP0000750_abnormal_muscle_regeneration0.75557623
134MP0002168_other_aberrant_phenotype0.75167066
135MP0002089_abnormal_postnatal_growth/wei0.74858908
136MP0000462_abnormal_digestive_system0.74470707
137MP0004147_increased_porphyrin_level0.74345932
138MP0005266_abnormal_metabolism0.72442678
139MP0002693_abnormal_pancreas_physiology0.72181540
140MP0002822_catalepsy0.71782109
141MP0002896_abnormal_bone_mineralization0.71227173
142MP0003953_abnormal_hormone_level0.70158203
143MP0010155_abnormal_intestine_physiology0.69796796
144MP0005375_adipose_tissue_phenotype0.67972994
145MP0005647_abnormal_sex_gland0.67882899
146MP0000566_synostosis0.67104305
147MP0006138_congestive_heart_failure0.66156577
148MP0000749_muscle_degeneration0.65837555
149MP0000604_amyloidosis0.64140598
150MP0005167_abnormal_blood-brain_barrier0.64095855
151MP0005165_increased_susceptibility_to0.62835297
152MP0009785_altered_susceptibility_to0.62684233
153MP0005448_abnormal_energy_balance0.62648080
154MP0005076_abnormal_cell_differentiation0.61680066
155MP0004085_abnormal_heartbeat0.61645674
156MP0005376_homeostasis/metabolism_phenot0.59619072
157MP0002132_abnormal_respiratory_system0.59427572
158MP0000358_abnormal_cell_content/0.58225437
159MP0000639_abnormal_adrenal_gland0.58076129
160MP0004142_abnormal_muscle_tone0.57464061
161MP0002229_neurodegeneration0.57196672
162MP0003959_abnormal_lean_body0.55099688
163MP0001664_abnormal_digestion0.52747622
164MP0001905_abnormal_dopamine_level0.50402673
165MP0005452_abnormal_adipose_tissue0.49870004
166MP0002970_abnormal_white_adipose0.49747521
167MP0004270_analgesia0.49473097
168MP0000003_abnormal_adipose_tissue0.49368814
169MP0000681_abnormal_thyroid_gland0.47076375
170MP0010678_abnormal_skin_adnexa0.46898382
171MP0006276_abnormal_autonomic_nervous0.46639382

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.45208799
2Hyperglycinemia (HP:0002154)5.00514553
3Hyperglycinuria (HP:0003108)4.74738128
4Abnormality of serine family amino acid metabolism (HP:0010894)4.29966933
5Abnormality of glycine metabolism (HP:0010895)4.29966933
6Intrahepatic cholestasis (HP:0001406)4.09562194
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.06674026
8Hypobetalipoproteinemia (HP:0003563)3.98336570
9Xanthomatosis (HP:0000991)3.94953644
10Deep venous thrombosis (HP:0002625)3.93067469
11Prolonged partial thromboplastin time (HP:0003645)3.87132271
12Gout (HP:0001997)3.77575483
13Ketosis (HP:0001946)3.65224514
14Vascular calcification (HP:0004934)3.65128381
15Hyperlipoproteinemia (HP:0010980)3.64186095
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.63222175
17Abnormal gallbladder physiology (HP:0012438)3.59611667
18Cholecystitis (HP:0001082)3.59611667
19Hyperammonemia (HP:0001987)3.51486871
20Cardiovascular calcification (HP:0011915)3.43608231
21Ketoacidosis (HP:0001993)3.30458017
22Distal upper limb amyotrophy (HP:0007149)3.26380130
23Upper limb amyotrophy (HP:0009129)3.26380130
24Hand muscle atrophy (HP:0009130)3.22163435
25Abnormality of fatty-acid metabolism (HP:0004359)3.16902289
26Albinism (HP:0001022)3.13274882
27Hypoglycemic coma (HP:0001325)3.11814752
28Cerebral edema (HP:0002181)3.07358804
29Hepatic necrosis (HP:0002605)3.07300058
30Acute encephalopathy (HP:0006846)3.05839572
31Abnormality of serum amino acid levels (HP:0003112)3.05148726
32Lethargy (HP:0001254)3.04423936
33Brushfield spots (HP:0001088)3.03838070
34Hyperphosphatemia (HP:0002905)3.00097059
35Hyperbilirubinemia (HP:0002904)2.96493364
36Hepatocellular necrosis (HP:0001404)2.93778796
37Complement deficiency (HP:0004431)2.93432585
38Delayed CNS myelination (HP:0002188)2.89928805
39Abnormal mitochondria in muscle tissue (HP:0008316)2.86378835
40Premature rupture of membranes (HP:0001788)2.83594671
41Late onset (HP:0003584)2.82496214
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.77821691
43Dicarboxylic aciduria (HP:0003215)2.77821691
44Hyperinsulinemic hypoglycemia (HP:0000825)2.76243034
45Asymmetric septal hypertrophy (HP:0001670)2.74429026
46Severe visual impairment (HP:0001141)2.72193452
47Thin bony cortex (HP:0002753)2.70326898
48Protrusio acetabuli (HP:0003179)2.68460166
49Nuclear cataract (HP:0100018)2.67022507
50Hypolipoproteinemia (HP:0010981)2.64649591
51CNS demyelination (HP:0007305)2.64047277
52Acute necrotizing encephalopathy (HP:0006965)2.63559138
53Abnormality of the intrinsic pathway (HP:0010989)2.62936129
54Increased muscle lipid content (HP:0009058)2.62790510
55Ragged-red muscle fibers (HP:0003200)2.61183856
56Abnormal gallbladder morphology (HP:0012437)2.61023642
57Cholelithiasis (HP:0001081)2.60025793
58Mucopolysacchariduria (HP:0008155)2.55419940
59Urinary glycosaminoglycan excretion (HP:0003541)2.55419940
60Abnormality of polysaccharide metabolism (HP:0011012)2.49599006
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49599006
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49599006
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.46019742
64Fat malabsorption (HP:0002630)2.45813924
65Progressive macrocephaly (HP:0004481)2.44206598
66Cerebral hypomyelination (HP:0006808)2.43688564
67Systemic lupus erythematosus (HP:0002725)2.43238373
68Spastic paraparesis (HP:0002313)2.43155798
69Increased intramyocellular lipid droplets (HP:0012240)2.42300221
70Global brain atrophy (HP:0002283)2.41972800
71Mitochondrial inheritance (HP:0001427)2.41316326
72Hemorrhage of the eye (HP:0011885)2.41212387
73Polycythemia (HP:0001901)2.40091295
74Abnormality of sulfur amino acid metabolism (HP:0004339)2.37294941
75Dysostosis multiplex (HP:0000943)2.35345416
76Progressive muscle weakness (HP:0003323)2.35243261
77Abnormality of the common coagulation pathway (HP:0010990)2.33055324
78Atelectasis (HP:0100750)2.28433880
79Increased CSF lactate (HP:0002490)2.26429153
80Neuronal loss in central nervous system (HP:0002529)2.25590696
81Distal lower limb muscle weakness (HP:0009053)2.24827732
82Lactic acidosis (HP:0003128)2.23520124
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23073962
84Irritability (HP:0000737)2.21808370
85Cervical subluxation (HP:0003308)2.21099056
86Hyperglycemia (HP:0003074)2.20612211
87Abnormality of the nasal mucosa (HP:0000433)2.20199922
88Abnormality of purine metabolism (HP:0004352)2.20108692
89Abnormality of methionine metabolism (HP:0010901)2.17247208
90Glycosuria (HP:0003076)2.15452958
91Abnormality of urine glucose concentration (HP:0011016)2.15452958
92Lipid accumulation in hepatocytes (HP:0006561)2.14935296
93Metabolic acidosis (HP:0001942)2.14119006
94Conjugated hyperbilirubinemia (HP:0002908)2.13724001
95Abnormality of nucleobase metabolism (HP:0010932)2.12709383
96Delusions (HP:0000746)2.11632102
97Ocular albinism (HP:0001107)2.09977758
98Loss of speech (HP:0002371)2.09803595
99Vomiting (HP:0002013)2.09342694
100Joint hemorrhage (HP:0005261)2.09335511
101Stridor (HP:0010307)2.08826505
102Hypoglycemic seizures (HP:0002173)2.08717618
103Segmental peripheral demyelination/remyelination (HP:0003481)2.08492695
104Cerebral aneurysm (HP:0004944)2.07522025
105Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05580389
106Nasal polyposis (HP:0100582)2.05453221
107Neonatal onset (HP:0003623)2.03690154
108Increased connective tissue (HP:0009025)2.03591066
109Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03436977
110Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03436977
111Supranuclear gaze palsy (HP:0000605)2.03013581
112Abnormality of liposaccharide metabolism (HP:0010968)2.00602840
113Abnormality of glycosphingolipid metabolism (HP:0004343)2.00602840
114Abnormality of glycolipid metabolism (HP:0010969)2.00602840
115Vertebral compression fractures (HP:0002953)1.99968439
116Peripheral hypomyelination (HP:0007182)1.98702021
117Abnormality of pyrimidine metabolism (HP:0004353)1.97910767
118Restlessness (HP:0000711)1.97729992
119Abnormality of complement system (HP:0005339)1.97282537
120Skin nodule (HP:0200036)1.97034247
121Rhabdomyolysis (HP:0003201)1.95762721
122Neurofibrillary tangles (HP:0002185)1.95701173
123Mildly elevated creatine phosphokinase (HP:0008180)1.94934488
124Reticulocytosis (HP:0001923)1.93658887
125J-shaped sella turcica (HP:0002680)1.93432754
126Increased serum pyruvate (HP:0003542)1.93017134
127Abnormality of glycolysis (HP:0004366)1.93017134
128Hypoalphalipoproteinemia (HP:0003233)1.92446354
129Spontaneous abortion (HP:0005268)1.91710835
130Achilles tendon contracture (HP:0001771)1.91484375
131Progressive neurologic deterioration (HP:0002344)1.91383733
132Distal lower limb amyotrophy (HP:0008944)1.90374220
133Abnormality of the gallbladder (HP:0005264)1.89864542
134Aplasia/Hypoplasia involving the musculature (HP:0001460)1.88776320
135Hammertoe (HP:0001765)1.88158463
136Interstitial pulmonary disease (HP:0006530)1.87214471
137Opisthotonus (HP:0002179)1.87075724
138Prolonged neonatal jaundice (HP:0006579)1.86984480
139Generalized aminoaciduria (HP:0002909)1.86484557
140Bell-shaped thorax (HP:0001591)1.86430032
141Cerebral inclusion bodies (HP:0100314)1.86348056
142Malnutrition (HP:0004395)1.84364156
143Increased purine levels (HP:0004368)1.84260318
144Hyperuricemia (HP:0002149)1.84260318
145Respiratory failure (HP:0002878)1.84182011
146Aneurysm (HP:0002617)1.83764231
147Steatorrhea (HP:0002570)1.83506762
148Ankle clonus (HP:0011448)1.83415497
149Amyloidosis (HP:0011034)1.82401690
150Abnormality of the Achilles tendon (HP:0005109)1.79756855
151Increased CSF protein (HP:0002922)1.79202668
152CNS hypomyelination (HP:0003429)1.78539635
153Abnormality of the periventricular white matter (HP:0002518)1.77953291
154Emotional lability (HP:0000712)1.76693350
155Increased serum lactate (HP:0002151)1.75843898
156Hyperthyroidism (HP:0000836)1.75320520
157Centrally nucleated skeletal muscle fibers (HP:0003687)1.75313177
158Tetraparesis (HP:0002273)1.72975803
159Hyperphosphaturia (HP:0003109)1.72848227
160Conjunctival hamartoma (HP:0100780)1.72742703
161Decreased motor nerve conduction velocity (HP:0003431)1.71283602
162Abnormality of the acetabulum (HP:0003170)1.71214656
163Upper limb muscle weakness (HP:0003484)1.70338003
164Slow saccadic eye movements (HP:0000514)1.70090807
165Hypertensive crisis (HP:0100735)1.69573973
166Short nail (HP:0001799)1.68486829
167Easy fatigability (HP:0003388)1.66955387
168Hyperparathyroidism (HP:0000843)1.66781498
169Osteolytic defects of the hand bones (HP:0009699)1.65009551
170Osteolytic defects of the phalanges of the hand (HP:0009771)1.65009551
171Hypertriglyceridemia (HP:0002155)1.64684960
172Axonal loss (HP:0003447)1.63977648
173Onion bulb formation (HP:0003383)1.63415717
174Aortic aneurysm (HP:0004942)1.62304392
175Iris hypopigmentation (HP:0007730)1.61808471
176Back pain (HP:0003418)1.61585350
177Abnormality of molar morphology (HP:0011070)1.61575493
178Abnormality of molar (HP:0011077)1.61575493
179Purpura (HP:0000979)1.60937176
180Abnormality of the dental root (HP:0006486)1.58534893
181Taurodontia (HP:0000679)1.58534893
182Abnormality of permanent molar morphology (HP:0011071)1.58534893
183Abdominal distention (HP:0003270)1.57887952
184Spinal rigidity (HP:0003306)1.57481251
185Bradycardia (HP:0001662)1.55459312
186Increased variability in muscle fiber diameter (HP:0003557)1.54914953
187Hyperacusis (HP:0010780)1.54649710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.24773345
2FRK3.66277990
3TAOK23.32442705
4TESK13.29259824
5BUB13.07290963
6TLK13.07031311
7MAP2K33.02126280
8MAP3K32.71084933
9TAOK12.60960191
10RIPK12.49205061
11PRPF4B2.45525508
12STK162.39181756
13NME22.36651405
14FGFR22.34649226
15WEE12.20324706
16BRD42.11343515
17BRSK21.96209649
18DYRK31.93343515
19EPHA21.81831451
20DMPK1.75597365
21TRIB31.71325034
22AKT31.68619163
23DDR21.67050283
24MUSK1.61759572
25INSRR1.59043715
26RIPK41.54385275
27STK391.53278951
28JAK31.52091574
29CSNK1G31.50426182
30PHKG21.49978329
31PHKG11.49978329
32MET1.49733622
33EPHB11.46984952
34PINK11.46420666
35MAP2K21.44314296
36BMPR21.43255650
37EIF2AK11.36504736
38NME11.34782140
39PRKD31.31786731
40MST1R1.30049548
41ERN11.27368506
42SIK31.25592760
43LMTK21.18153001
44CSNK1G11.17108661
45PRKD21.15198145
46ABL21.11752525
47MAP3K21.11326669
48PDK31.10472620
49PDK41.10472620
50CDK191.10440732
51TYK21.09838640
52CSNK1G21.08309458
53OXSR11.07642672
54CDK121.05673594
55FES1.04953021
56PRKG21.01051487
57RPS6KA20.99193287
58MARK20.99108917
59MAP2K40.98967876
60CDC42BPA0.98754982
61RAF10.98098725
62WNK40.97814189
63CSNK1A1L0.97089039
64CDK80.96985565
65LATS20.95659957
66TESK20.93861842
67KSR20.91668522
68CLK10.90975242
69TBK10.90195871
70ACVR1B0.90031340
71BRAF0.89809379
72TIE10.89330666
73BRSK10.88328829
74MAP3K80.88136268
75BLK0.87948719
76EIF2AK30.87845364
77PDGFRA0.87030689
78PDK10.86656362
79MAPKAPK50.85048225
80CCNB10.84129523
81ZAP700.83268019
82MAP3K130.83058342
83IRAK30.82836549
84ARAF0.82107913
85LIMK10.81734389
86PTK60.81250976
87DYRK20.80154560
88EEF2K0.79803174
89NTRK10.78410481
90MAP3K110.77238132
91TNK20.75721857
92PIM20.74777857
93TNIK0.74141885
94SMG10.73949891
95PAK30.73872824
96BMX0.72724698
97PKN20.71505700
98STK110.71391094
99ICK0.71381397
100SIK10.71042627
101TAOK30.70720872
102PTK2B0.70131647
103MAP3K10.70069838
104DYRK1B0.67324945
105AURKA0.67193182
106MTOR0.66997831
107MAPKAPK30.66018480
108HIPK20.65995878
109ERBB20.64681009
110MAPK110.64233216
111JAK20.63039617
112PRKCI0.62105014
113MAPK150.60525589
114MAP3K50.59196806
115RET0.58630636
116MKNK10.58401492
117PAK60.57838040
118FLT30.56509086
119PRKAA10.56407155
120NEK20.55794310
121STK380.54932761
122PNCK0.54247016
123JAK10.53453441
124EPHA40.52252309
125PRKD10.51635782
126NEK10.51246213
127MAPK120.51085519
128PAK40.49978334
129UHMK10.49539523
130MOS0.49463052
131ROCK20.48657805
132MAP2K10.48418157
133TGFBR20.47474081
134RPS6KC10.47282826
135RPS6KL10.47282826
136MYLK0.46607672
137STK38L0.46378841
138NEK60.45912913
139MKNK20.45632858
140CAMK2G0.44977055
141OBSCN0.44888967
142PDPK10.44609024
143PAK20.44519862
144FER0.42381332
145AKT20.42342750
146TTN0.41895393
147CSNK1E0.40963297
148TSSK60.40795716
149EPHA30.40232896
150PASK0.40194197
151PRKCG0.39738329
152PIK3CG0.39712517
153TGFBR10.39480201
154DYRK1A0.39460003
155MST40.38852786
156FGFR40.38398658
157MAP3K70.38393825
158PTK20.37248414
159PRKACB0.37196277
160PAK10.37104925
161PRKAA20.37061136
162ROCK10.36694961
163LRRK20.36150670
164SRC0.35552912
165SGK30.35165149

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.98462074
2Other glycan degradation_Homo sapiens_hsa005112.91452030
3Vitamin B6 metabolism_Homo sapiens_hsa007502.84377959
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69405106
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.68855376
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54252671
7Butanoate metabolism_Homo sapiens_hsa006502.52275983
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.49336929
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.33468363
10Folate biosynthesis_Homo sapiens_hsa007902.21834352
11SNARE interactions in vesicular transport_Homo sapiens_hsa041302.16606893
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14932812
13Fatty acid degradation_Homo sapiens_hsa000712.11439243
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.07896920
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06212623
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.05688967
17Tryptophan metabolism_Homo sapiens_hsa003802.04003289
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03182597
19Propanoate metabolism_Homo sapiens_hsa006401.95928619
20Arginine biosynthesis_Homo sapiens_hsa002201.93088070
21Nitrogen metabolism_Homo sapiens_hsa009101.91199514
22Sulfur metabolism_Homo sapiens_hsa009201.89373515
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86982083
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81422129
25Peroxisome_Homo sapiens_hsa041461.74658421
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.71649028
27Fatty acid elongation_Homo sapiens_hsa000621.63004405
28Selenocompound metabolism_Homo sapiens_hsa004501.62141994
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.61897972
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60007794
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.57466539
32Lysosome_Homo sapiens_hsa041421.53090124
33beta-Alanine metabolism_Homo sapiens_hsa004101.50858194
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50066769
35Sulfur relay system_Homo sapiens_hsa041221.47647600
36Pyruvate metabolism_Homo sapiens_hsa006201.46701640
37Fatty acid metabolism_Homo sapiens_hsa012121.45086005
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43511378
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42966859
40Complement and coagulation cascades_Homo sapiens_hsa046101.42029572
41Carbon metabolism_Homo sapiens_hsa012001.40798371
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39852983
43Histidine metabolism_Homo sapiens_hsa003401.39024236
44Biosynthesis of amino acids_Homo sapiens_hsa012301.38794424
45Acute myeloid leukemia_Homo sapiens_hsa052211.35581232
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35351405
47Protein export_Homo sapiens_hsa030601.34460964
48Oxidative phosphorylation_Homo sapiens_hsa001901.33104492
49VEGF signaling pathway_Homo sapiens_hsa043701.30864615
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27186526
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26598727
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23059104
53Arginine and proline metabolism_Homo sapiens_hsa003301.20378621
54Non-small cell lung cancer_Homo sapiens_hsa052231.19208811
55Amoebiasis_Homo sapiens_hsa051461.18899111
56Estrogen signaling pathway_Homo sapiens_hsa049151.18850055
57Vitamin digestion and absorption_Homo sapiens_hsa049771.17745123
58Parkinsons disease_Homo sapiens_hsa050121.17347120
59Fat digestion and absorption_Homo sapiens_hsa049751.15785058
60Starch and sucrose metabolism_Homo sapiens_hsa005001.14933496
61Choline metabolism in cancer_Homo sapiens_hsa052311.12780194
62PPAR signaling pathway_Homo sapiens_hsa033201.12195959
63Phenylalanine metabolism_Homo sapiens_hsa003601.10423471
64Phospholipase D signaling pathway_Homo sapiens_hsa040721.08804251
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05799469
66Chemical carcinogenesis_Homo sapiens_hsa052041.05249264
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03319889
68B cell receptor signaling pathway_Homo sapiens_hsa046621.01981000
69Chronic myeloid leukemia_Homo sapiens_hsa052201.01752662
70Insulin resistance_Homo sapiens_hsa049311.01393983
71Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00136319
72GnRH signaling pathway_Homo sapiens_hsa049120.99715843
73Tyrosine metabolism_Homo sapiens_hsa003500.98681155
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97937465
75RNA polymerase_Homo sapiens_hsa030200.97718320
76Leishmaniasis_Homo sapiens_hsa051400.97086278
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.96734273
78Toxoplasmosis_Homo sapiens_hsa051450.96677957
79Osteoclast differentiation_Homo sapiens_hsa043800.96178552
80Galactose metabolism_Homo sapiens_hsa000520.95808334
81Influenza A_Homo sapiens_hsa051640.94680843
82Bile secretion_Homo sapiens_hsa049760.94234827
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93955625
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.93677116
85Insulin signaling pathway_Homo sapiens_hsa049100.92089703
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.91130121
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90087732
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89274288
89Regulation of autophagy_Homo sapiens_hsa041400.89268683
90Ribosome_Homo sapiens_hsa030100.89044872
91Phagosome_Homo sapiens_hsa041450.88416106
92Endometrial cancer_Homo sapiens_hsa052130.88120771
93Shigellosis_Homo sapiens_hsa051310.87918979
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87515041
95Synaptic vesicle cycle_Homo sapiens_hsa047210.86829098
96Endocytosis_Homo sapiens_hsa041440.85925903
97Hepatitis C_Homo sapiens_hsa051600.85340681
98Focal adhesion_Homo sapiens_hsa045100.83073673
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83013037
100Alzheimers disease_Homo sapiens_hsa050100.82936125
101Viral myocarditis_Homo sapiens_hsa054160.82874023
102Renal cell carcinoma_Homo sapiens_hsa052110.82782809
103Retinol metabolism_Homo sapiens_hsa008300.80150714
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80018997
105Caffeine metabolism_Homo sapiens_hsa002320.79299081
106Metabolic pathways_Homo sapiens_hsa011000.78497316
107Bladder cancer_Homo sapiens_hsa052190.77633300
108Steroid biosynthesis_Homo sapiens_hsa001000.77083965
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.76945293
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76380779
111TNF signaling pathway_Homo sapiens_hsa046680.76150782
112Tuberculosis_Homo sapiens_hsa051520.75383709
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75259563
114Fructose and mannose metabolism_Homo sapiens_hsa000510.74490228
115Glutathione metabolism_Homo sapiens_hsa004800.73662577
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73542693
117ABC transporters_Homo sapiens_hsa020100.72908969
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72864680
119Glioma_Homo sapiens_hsa052140.72165862
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.72153715
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70905605
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70623885
123Pentose phosphate pathway_Homo sapiens_hsa000300.70474127
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.69452589
125Adherens junction_Homo sapiens_hsa045200.68451254
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67941260
127ErbB signaling pathway_Homo sapiens_hsa040120.67766305
128AMPK signaling pathway_Homo sapiens_hsa041520.66913044
129Pyrimidine metabolism_Homo sapiens_hsa002400.65581578
130Sphingolipid metabolism_Homo sapiens_hsa006000.65158704
131Salmonella infection_Homo sapiens_hsa051320.64969559
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63551123
133Cardiac muscle contraction_Homo sapiens_hsa042600.61884463
134Pancreatic cancer_Homo sapiens_hsa052120.61603482
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.60825872
136Huntingtons disease_Homo sapiens_hsa050160.60339129
137Vibrio cholerae infection_Homo sapiens_hsa051100.57978583
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57584366
139HIF-1 signaling pathway_Homo sapiens_hsa040660.57391760
140Linoleic acid metabolism_Homo sapiens_hsa005910.57374138
141mTOR signaling pathway_Homo sapiens_hsa041500.55839245
142Glycerolipid metabolism_Homo sapiens_hsa005610.55731138
143Notch signaling pathway_Homo sapiens_hsa043300.55013982
144Prolactin signaling pathway_Homo sapiens_hsa049170.51745499
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50742283
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49420533
147Inositol phosphate metabolism_Homo sapiens_hsa005620.49185630
148Type II diabetes mellitus_Homo sapiens_hsa049300.48864773
149Hepatitis B_Homo sapiens_hsa051610.48159217
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48108701
151Platelet activation_Homo sapiens_hsa046110.48081155
152Long-term potentiation_Homo sapiens_hsa047200.47002828
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46830510
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45358405
155One carbon pool by folate_Homo sapiens_hsa006700.39505533
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39464712
157Lysine degradation_Homo sapiens_hsa003100.36783552
158Proteasome_Homo sapiens_hsa030500.35259353
159Prion diseases_Homo sapiens_hsa050200.34657133
160Purine metabolism_Homo sapiens_hsa002300.31728690
161Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28826626
162Staphylococcus aureus infection_Homo sapiens_hsa051500.28408280
163Arachidonic acid metabolism_Homo sapiens_hsa005900.26562002
164Insulin secretion_Homo sapiens_hsa049110.24592740
165Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19296427
166Pancreatic secretion_Homo sapiens_hsa049720.18246444
167Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.12729699
168N-Glycan biosynthesis_Homo sapiens_hsa005100.12493035
169Glucagon signaling pathway_Homo sapiens_hsa049220.11262370
170Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.10207281
171Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09934387
172Cocaine addiction_Homo sapiens_hsa050300.06461908

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