GORASP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)8.75889489
2protein retention in ER lumen (GO:0006621)8.12423506
3COPII vesicle coating (GO:0048208)7.50425840
4protein maturation by protein folding (GO:0022417)6.58105250
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.56973624
6signal peptide processing (GO:0006465)6.20378157
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)6.20168388
8positive regulation of nuclease activity (GO:0032075)5.97269014
9regulation of nuclease activity (GO:0032069)5.45055491
10endoplasmic reticulum unfolded protein response (GO:0030968)5.41200184
11cellular response to unfolded protein (GO:0034620)5.29314847
12vesicle coating (GO:0006901)5.20942455
13exocrine pancreas development (GO:0031017)5.19889383
14cellular response to topologically incorrect protein (GO:0035967)5.12212257
15ER-nucleus signaling pathway (GO:0006984)4.99342120
16endocrine pancreas development (GO:0031018)4.93388133
17ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.84589900
18sequestering of metal ion (GO:0051238)4.54678380
19protein N-linked glycosylation via asparagine (GO:0018279)4.53767641
20proline biosynthetic process (GO:0006561)4.51222845
21peptidyl-asparagine modification (GO:0018196)4.50928748
224-hydroxyproline metabolic process (GO:0019471)4.49658822
23response to endoplasmic reticulum stress (GO:0034976)4.49639425
24regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.48631774
25response to unfolded protein (GO:0006986)4.28265632
26protein N-linked glycosylation (GO:0006487)4.17801055
27regulation of type B pancreatic cell apoptotic process (GO:2000674)4.17662127
28response to topologically incorrect protein (GO:0035966)4.16668962
29peptide hormone processing (GO:0016486)4.09053262
30ER to Golgi vesicle-mediated transport (GO:0006888)3.99380022
31ribosome assembly (GO:0042255)3.93311083
32intestinal cholesterol absorption (GO:0030299)3.88441773
33ER overload response (GO:0006983)3.87527065
34peptidyl-proline hydroxylation (GO:0019511)3.87206090
35glandular epithelial cell differentiation (GO:0002067)3.69373457
36UDP-N-acetylglucosamine metabolic process (GO:0006047)3.66249658
37GDP-mannose metabolic process (GO:0019673)3.61643815
38nucleotide-sugar biosynthetic process (GO:0009226)3.57564876
39type B pancreatic cell development (GO:0003323)3.55631371
40regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.50749521
41regulation of Golgi to plasma membrane protein transport (GO:0042996)3.50502043
42spliceosomal tri-snRNP complex assembly (GO:0000244)3.48764777
43peptidyl-arginine omega-N-methylation (GO:0035247)3.38390714
44desmosome organization (GO:0002934)3.38232950
45Golgi organization (GO:0007030)3.37530007
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.36065976
47L-phenylalanine metabolic process (GO:0006558)3.36065976
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.30819611
49L-phenylalanine catabolic process (GO:0006559)3.30819611
50pteridine-containing compound biosynthetic process (GO:0042559)3.30479158
51protein autoprocessing (GO:0016540)3.30060570
52cell redox homeostasis (GO:0045454)3.28572971
53formation of translation preinitiation complex (GO:0001731)3.27427635
54regulation of translational fidelity (GO:0006450)3.25518682
55nuclear pore complex assembly (GO:0051292)3.23968820
56regulation of corticosteroid hormone secretion (GO:2000846)3.23571313
57folic acid-containing compound biosynthetic process (GO:0009396)3.22050640
58DNA unwinding involved in DNA replication (GO:0006268)3.21893999
59glandular epithelial cell development (GO:0002068)3.20661119
60protein hydroxylation (GO:0018126)3.18116709
61regulation of translational termination (GO:0006449)3.11605345
62intra-Golgi vesicle-mediated transport (GO:0006891)3.09541651
63keratan sulfate catabolic process (GO:0042340)3.06495970
64pinocytosis (GO:0006907)3.05848165
65establishment of integrated proviral latency (GO:0075713)3.05802924
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02242464
67establishment of viral latency (GO:0019043)3.02209422
68L-alpha-amino acid transmembrane transport (GO:1902475)3.01277411
69nucleotide-sugar metabolic process (GO:0009225)2.98445298
70maintenance of protein localization in organelle (GO:0072595)2.96431787
71NADH metabolic process (GO:0006734)2.93941645
72toxin metabolic process (GO:0009404)2.89745841
73proline metabolic process (GO:0006560)2.87323546
74nuclear pore organization (GO:0006999)2.86057903
75peptide catabolic process (GO:0043171)2.85742658
76mitotic chromosome condensation (GO:0007076)2.81321548
77tricarboxylic acid metabolic process (GO:0072350)2.81127446
78intestinal absorption (GO:0050892)2.81123174
79positive regulation of insulin secretion (GO:0032024)2.81015251
80protein localization to Golgi apparatus (GO:0034067)2.80612189
81tRNA aminoacylation for protein translation (GO:0006418)2.78605068
823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.77858155
83purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.77858155
84negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.73559673
85cellular response to vitamin D (GO:0071305)2.73243741
86cellular zinc ion homeostasis (GO:0006882)2.70393003
87mitotic nuclear envelope reassembly (GO:0007084)2.69039909
88nuclear envelope reassembly (GO:0031468)2.69039909
89Golgi vesicle transport (GO:0048193)2.68451297
90skin morphogenesis (GO:0043589)2.64941809
91tRNA aminoacylation (GO:0043039)2.64251146
92amino acid activation (GO:0043038)2.64251146
93peptidyl-arginine N-methylation (GO:0035246)2.64035453
94peptidyl-arginine methylation (GO:0018216)2.64035453
95mitochondrial calcium ion transport (GO:0006851)2.63652341
96basement membrane organization (GO:0071711)2.63326939
97chaperone-mediated protein folding (GO:0061077)2.63140331
98positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.62640040
99regulation of mammary gland epithelial cell proliferation (GO:0033599)2.60679866
100glucose 6-phosphate metabolic process (GO:0051156)2.59901317
101nucleobase-containing small molecule interconversion (GO:0015949)2.59212432
102regulation of RNA export from nucleus (GO:0046831)2.59142916
103regulation of metalloenzyme activity (GO:0048552)2.58464045
104mitotic nuclear envelope disassembly (GO:0007077)2.58301154
105histone arginine methylation (GO:0034969)2.57558794
106negative regulation of mRNA processing (GO:0050686)2.57501395
107digestion (GO:0007586)2.57489077
108dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.56668627
109DNA strand elongation (GO:0022616)2.56001320
110cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.54582651
111columnar/cuboidal epithelial cell development (GO:0002066)2.54209178
112membrane budding (GO:0006900)2.52279738
113valine metabolic process (GO:0006573)2.51607517
114DNA strand elongation involved in DNA replication (GO:0006271)2.51406477
115localization within membrane (GO:0051668)2.49183642
116response to hexose (GO:0009746)2.49037056
117fucose metabolic process (GO:0006004)2.48808112
118regulation of glucocorticoid secretion (GO:2000849)2.46932915
119nuclear envelope disassembly (GO:0051081)2.45856985
120membrane disassembly (GO:0030397)2.45856985
121response to monosaccharide (GO:0034284)2.43118985
122cellular response to nutrient (GO:0031670)2.43085714
123response to glucose (GO:0009749)2.43074102
124positive regulation of steroid hormone secretion (GO:2000833)2.42580494
125negative regulation of glycoprotein biosynthetic process (GO:0010561)2.40708282
126regulation of hexokinase activity (GO:1903299)2.40403439
127regulation of glucokinase activity (GO:0033131)2.40403439
128misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.40085184
129maternal placenta development (GO:0001893)2.39841534
130zinc ion transport (GO:0006829)2.39240932
131regulation of nucleobase-containing compound transport (GO:0032239)2.37933163
132lipopolysaccharide biosynthetic process (GO:0009103)2.37459842
133L-serine metabolic process (GO:0006563)2.36460293
134L-serine transport (GO:0015825)2.35616350
135peptidyl-proline modification (GO:0018208)2.33274388
136virion assembly (GO:0019068)2.33221894
137pore complex assembly (GO:0046931)2.33115494
138negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.32708583
139regulation of cholesterol homeostasis (GO:2000188)2.31647786
140regulation of translation in response to stress (GO:0043555)2.30378952
141mitotic metaphase plate congression (GO:0007080)2.30291866
142lymphocyte apoptotic process (GO:0070227)2.29690968
143negative regulation of ligase activity (GO:0051352)2.29407857
144negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.29407857
145protein carboxylation (GO:0018214)2.28618987
146peptidyl-glutamic acid carboxylation (GO:0017187)2.28618987
147regulation of cellular amino acid metabolic process (GO:0006521)2.26966742
148post-translational protein modification (GO:0043687)2.26795113
149positive regulation of endothelial cell apoptotic process (GO:2000353)2.26589636
150gluconeogenesis (GO:0006094)2.24580378
151NADPH regeneration (GO:0006740)2.24579255
152tricarboxylic acid cycle (GO:0006099)2.24210706
153anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.23555093
154positive regulation of extracellular matrix organization (GO:1903055)2.22385664
155regulation of mitotic spindle organization (GO:0060236)2.21708628
156protein export from nucleus (GO:0006611)2.20729032
157regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.19812673
158pentose-phosphate shunt (GO:0006098)2.19586627
159COPI coating of Golgi vesicle (GO:0048205)11.8833465
160Golgi transport vesicle coating (GO:0048200)11.8833465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.00669552
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.78127540
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.91289407
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83590712
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.78712704
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78679973
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.69277148
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55807598
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.49276216
10PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.46302469
11CLOCK_20551151_ChIP-Seq_293T_Human2.45412716
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.40988909
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.38827796
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.33920874
15AR_21909140_ChIP-Seq_LNCAP_Human2.25386741
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25355206
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18658582
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18044796
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11192145
20ZNF263_19887448_ChIP-Seq_K562_Human2.09754734
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.09651582
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06924507
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99990224
24* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99627803
25* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98452381
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.83235075
27* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82549525
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81751545
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80059882
30GATA1_22025678_ChIP-Seq_K562_Human1.75094244
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73377697
32TFEB_21752829_ChIP-Seq_HELA_Human1.72428383
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72240316
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71936757
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71412720
36GABP_19822575_ChIP-Seq_HepG2_Human1.70726076
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.69932836
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67443948
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59549624
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58929421
41DCP1A_22483619_ChIP-Seq_HELA_Human1.58154314
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.54201129
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52755993
44* ETS1_20019798_ChIP-Seq_JURKAT_Human1.52477122
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52421077
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.49875371
47* MYC_22102868_ChIP-Seq_BL_Human1.48210442
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47841391
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47564721
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46899299
51TBX5_21415370_ChIP-Seq_HL-1_Mouse1.45603151
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45571367
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44744801
54* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44456586
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44072699
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42067503
57LXR_22292898_ChIP-Seq_THP-1_Human1.40081697
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39254783
59* ATF3_27146783_Chip-Seq_COLON_Human1.38445881
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35684333
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.34483702
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34044976
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33415615
64* TTF2_22483619_ChIP-Seq_HELA_Human1.32872976
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31374180
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31244102
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.30959041
68CHD1_26751641_Chip-Seq_LNCaP_Human1.30925380
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30667555
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30220023
71* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29470171
72* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28248650
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27921775
74* E2F1_21310950_ChIP-Seq_MCF-7_Human1.27381181
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26066630
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25716795
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25577656
78* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24979738
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24527342
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24009204
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.23633649
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23142683
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22413541
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20962964
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20398934
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19952677
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19900037
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19362203
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18423112
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18221796
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17900550
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17707274
93* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16321500
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16054898
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15840659
96GATA4_25053715_ChIP-Seq_YYC3_Human1.15780155
97RACK7_27058665_Chip-Seq_MCF-7_Human1.14845076
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14447365
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14074880
100XRN2_22483619_ChIP-Seq_HELA_Human1.11466855
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11216644
102* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10991087
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10791566
104* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10198859
105ELK1_22589737_ChIP-Seq_MCF10A_Human1.09676388
106* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09653803
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07966965
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07763687
109CIITA_25753668_ChIP-Seq_RAJI_Human1.07714473
110* FOXP3_21729870_ChIP-Seq_TREG_Human1.06829921
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04275882
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03241762
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03186406
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03117931
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02806649
116* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01802173
117IRF8_22096565_ChIP-ChIP_GC-B_Human1.01797654
118GATA6_25053715_ChIP-Seq_YYC3_Human1.00354042
119* ELK3_25401928_ChIP-Seq_HUVEC_Human1.00246877
120GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.99814251
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98967411
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98826907
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.96736604
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96180665
125KDM5A_27292631_Chip-Seq_BREAST_Human0.95839511
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95418690
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95064600
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.94524957
129* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94474660
130SOX2_20726797_ChIP-Seq_SW620_Human0.92907180
131* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91435988
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91124304
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90901455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.07006520
2MP0005220_abnormal_exocrine_pancreas3.43326661
3MP0002139_abnormal_hepatobiliary_system3.33271442
4MP0000013_abnormal_adipose_tissue3.25809620
5MP0008438_abnormal_cutaneous_collagen3.00952001
6MP0005365_abnormal_bile_salt2.80014140
7MP0001944_abnormal_pancreas_morphology2.78056830
8MP0003283_abnormal_digestive_organ2.76360094
9MP0002693_abnormal_pancreas_physiology2.73347532
10MP0003195_calcinosis2.67131042
11MP0001666_abnormal_nutrient_absorption2.45689755
12MP0003111_abnormal_nucleus_morphology2.43549524
13MP0004957_abnormal_blastocyst_morpholog2.40165537
14MP0005451_abnormal_body_composition2.38714473
15MP0005084_abnormal_gallbladder_morpholo2.26727300
16MP0003705_abnormal_hypodermis_morpholog2.25061708
17MP0005083_abnormal_biliary_tract2.24595031
18MP0006054_spinal_hemorrhage2.23064160
19MP0009780_abnormal_chondrocyte_physiolo2.22242537
20MP0010386_abnormal_urinary_bladder2.14813171
21MP0002909_abnormal_adrenal_gland2.10467712
22MP0002138_abnormal_hepatobiliary_system2.09108592
23MP0001730_embryonic_growth_arrest2.01470102
24MP0004264_abnormal_extraembryonic_tissu1.96616443
25MP0000003_abnormal_adipose_tissue1.92045493
26MP0003868_abnormal_feces_composition1.88260576
27MP0008932_abnormal_embryonic_tissue1.87707936
28MP0004043_abnormal_pH_regulation1.85868087
29MP0003806_abnormal_nucleotide_metabolis1.83079351
30MP0010094_abnormal_chromosome_stability1.75534302
31MP0003300_gastrointestinal_ulcer1.70310354
32MP0005058_abnormal_lysosome_morphology1.68599417
33MP0002896_abnormal_bone_mineralization1.67582401
34MP0003252_abnormal_bile_duct1.67454103
35MP0005501_abnormal_skin_physiology1.67215522
36MP0000678_abnormal_parathyroid_gland1.62418688
37MP0005076_abnormal_cell_differentiation1.60879293
38MP0002796_impaired_skin_barrier1.60131250
39MP0009384_cardiac_valve_regurgitation1.59829796
40MP0003077_abnormal_cell_cycle1.59407953
41MP0003941_abnormal_skin_development1.56645576
42MP0002078_abnormal_glucose_homeostasis1.56011560
43MP0005275_abnormal_skin_tensile1.54267675
44MP0005085_abnormal_gallbladder_physiolo1.54235118
45MP0005623_abnormal_meninges_morphology1.54050536
46MP0005503_abnormal_tendon_morphology1.49634111
47MP0002933_joint_inflammation1.49619429
48MP0003950_abnormal_plasma_membrane1.49170313
49MP0002837_dystrophic_cardiac_calcinosis1.46722402
50MP0003566_abnormal_cell_adhesion1.45526718
51MP0009643_abnormal_urine_homeostasis1.44220437
52MP0008058_abnormal_DNA_repair1.43130510
53MP0008007_abnormal_cellular_replicative1.42909410
54MP0005257_abnormal_intraocular_pressure1.42759280
55MP0000350_abnormal_cell_proliferation1.41870303
56MP0004272_abnormal_basement_membrane1.41141159
57MP0008260_abnormal_autophagy1.39924795
58MP0003183_abnormal_peptide_metabolism1.39296259
59MP0010368_abnormal_lymphatic_system1.36184744
60MP0009840_abnormal_foam_cell1.35666709
61MP0005379_endocrine/exocrine_gland_phen1.35270190
62MP0005360_urolithiasis1.33651821
63MP0002080_prenatal_lethality1.33179336
64MP0001672_abnormal_embryogenesis/_devel1.29962593
65MP0005380_embryogenesis_phenotype1.29962593
66MP0001915_intracranial_hemorrhage1.28902761
67MP0001849_ear_inflammation1.25529623
68MP0002928_abnormal_bile_duct1.24301133
69MP0003984_embryonic_growth_retardation1.22151165
70MP0000858_altered_metastatic_potential1.22146756
71MP0009697_abnormal_copulation1.20560269
72MP0010352_gastrointestinal_tract_polyps1.20349972
73MP0000163_abnormal_cartilage_morphology1.17329653
74MP0003786_premature_aging1.17237905
75MP0001697_abnormal_embryo_size1.14939235
76MP0003959_abnormal_lean_body1.14898716
77MP0001216_abnormal_epidermal_layer1.13122414
78MP0002088_abnormal_embryonic_growth/wei1.13096404
79MP0002086_abnormal_extraembryonic_tissu1.12387232
80MP0003186_abnormal_redox_activity1.09871160
81MP0000613_abnormal_salivary_gland1.09801569
82MP0010030_abnormal_orbit_morphology1.08724342
83MP0003172_abnormal_lysosome_physiology1.05783642
84MP0005621_abnormal_cell_physiology1.05128283
85MP0003221_abnormal_cardiomyocyte_apopto1.04673463
86MP0003795_abnormal_bone_structure1.03639668
87MP0004134_abnormal_chest_morphology1.03605956
88MP0003119_abnormal_digestive_system1.03037534
89MP0001661_extended_life_span1.01926050
90MP0001533_abnormal_skeleton_physiology0.99556930
91MP0003693_abnormal_embryo_hatching0.98794778
92MP0003279_aneurysm0.97872663
93MP0005375_adipose_tissue_phenotype0.97520262
94MP0005332_abnormal_amino_acid0.96582070
95MP0002118_abnormal_lipid_homeostasis0.95791110
96MP0000751_myopathy0.95455368
97MP0000762_abnormal_tongue_morphology0.94619700
98MP0005636_abnormal_mineral_homeostasis0.94167517
99MP0000609_abnormal_liver_physiology0.93850332
100MP0005384_cellular_phenotype0.92878130
101MP0001727_abnormal_embryo_implantation0.92789189
102MP0000358_abnormal_cell_content/0.92676795
103MP0005408_hypopigmentation0.92383493
104MP0005023_abnormal_wound_healing0.92138217
105MP0000462_abnormal_digestive_system0.91517787
106MP0001765_abnormal_ion_homeostasis0.90101674
107MP0001348_abnormal_lacrimal_gland0.90052982
108MP0001756_abnormal_urination0.88830303
109MP0003123_paternal_imprinting0.88433612
110MP0001270_distended_abdomen0.88375943
111MP0005319_abnormal_enzyme/_coenzyme0.88122759
112MP0004197_abnormal_fetal_growth/weight/0.88119462
113MP0002085_abnormal_embryonic_tissue0.87851134
114MP0002295_abnormal_pulmonary_circulatio0.87355530
115MP0000313_abnormal_cell_death0.86395746
116MP0003718_maternal_effect0.86372953
117MP0005508_abnormal_skeleton_morphology0.85383031
118MP0001881_abnormal_mammary_gland0.84667266
119MP0003385_abnormal_body_wall0.84282462
120MP0009672_abnormal_birth_weight0.83536491
121MP0001542_abnormal_bone_strength0.83061451
122MP0000467_abnormal_esophagus_morphology0.82926569
123MP0008057_abnormal_DNA_replication0.82062286
124MP0010329_abnormal_lipoprotein_level0.82021410
125MP0009333_abnormal_splenocyte_physiolog0.82008067
126MP0010234_abnormal_vibrissa_follicle0.81784966
127MP0005330_cardiomyopathy0.81559028
128MP0002089_abnormal_postnatal_growth/wei0.80940301
129MP0003953_abnormal_hormone_level0.80903258
130MP0003453_abnormal_keratinocyte_physiol0.78938603
131MP0002084_abnormal_developmental_patter0.78600346
132MP0000598_abnormal_liver_morphology0.77952816
133MP0005390_skeleton_phenotype0.77674229
134MP0001299_abnormal_eye_distance/0.77603459
135MP0009931_abnormal_skin_appearance0.77543058
136MP0002269_muscular_atrophy0.77273655
137MP0004233_abnormal_muscle_weight0.76965192
138MP0002970_abnormal_white_adipose0.76282518
139MP0004782_abnormal_surfactant_physiolog0.76234075
140MP0001958_emphysema0.75803681
141MP0004858_abnormal_nervous_system0.75296317
142MP0000767_abnormal_smooth_muscle0.74761241
143MP0000627_abnormal_mammary_gland0.73946548
144MP0004185_abnormal_adipocyte_glucose0.73753819
145MP0001243_abnormal_dermal_layer0.72500166
146MP0002115_abnormal_skeleton_extremities0.72295119
147MP0003115_abnormal_respiratory_system0.71660818
148MP0003091_abnormal_cell_migration0.69876463
149MP0006036_abnormal_mitochondrial_physio0.68580281
150MP0010307_abnormal_tumor_latency0.67645128
151MP0010771_integument_phenotype0.67141590
152MP0002060_abnormal_skin_morphology0.66428481
153MP0002113_abnormal_skeleton_development0.65359714
154MP0002234_abnormal_pharynx_morphology0.62961279
155MP0003436_decreased_susceptibility_to0.61170226
156MP0008961_abnormal_basal_metabolism0.59738438
157MP0003942_abnormal_urinary_system0.59299497
158MP0009642_abnormal_blood_homeostasis0.59265611
159MP0000639_abnormal_adrenal_gland0.57782460
160MP0006072_abnormal_retinal_apoptosis0.56813587
161MP0005670_abnormal_white_adipose0.56119232

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)4.64033945
2Hypoglycemic coma (HP:0001325)4.51062179
3Hyperinsulinemic hypoglycemia (HP:0000825)4.33526746
4Epiphyseal dysplasia (HP:0002656)4.03622134
5Abnormal gallbladder physiology (HP:0012438)4.01581011
6Cholecystitis (HP:0001082)4.01581011
7Abnormality of the intrinsic pathway (HP:0010989)3.91001699
8Symptomatic seizures (HP:0011145)3.86292738
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.75996290
10Abnormality of glycolysis (HP:0004366)3.49584437
11Abnormal tarsal ossification (HP:0008369)3.47410761
12Hyperglycemia (HP:0003074)3.44610974
13Beaking of vertebral bodies (HP:0004568)3.43929515
14Deep venous thrombosis (HP:0002625)3.33635201
15Late onset (HP:0003584)3.29820672
16Protrusio acetabuli (HP:0003179)3.29760337
17Cervical subluxation (HP:0003308)3.25812011
18Abnormality of endocrine pancreas physiology (HP:0012093)3.20475126
19Abnormality of the pancreatic islet cells (HP:0006476)3.20475126
20Increased serum pyruvate (HP:0003542)3.16415193
21Ketoacidosis (HP:0001993)3.11356725
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.08268043
23Mucopolysacchariduria (HP:0008155)3.02872945
24Urinary glycosaminoglycan excretion (HP:0003541)3.02872945
25Abnormal pancreas size (HP:0012094)3.00686985
26Irregular epiphyses (HP:0010582)2.99513874
27Abnormal foot bone ossification (HP:0010675)2.96519030
28Generalized aminoaciduria (HP:0002909)2.95830406
29Dysostosis multiplex (HP:0000943)2.91172604
30Thoracolumbar scoliosis (HP:0002944)2.85050656
31Premature rupture of membranes (HP:0001788)2.81474527
32Protuberant abdomen (HP:0001538)2.77868855
33Upper limb amyotrophy (HP:0009129)2.72904495
34Distal upper limb amyotrophy (HP:0007149)2.72904495
35Insulin-resistant diabetes mellitus (HP:0000831)2.68506596
36Flat capital femoral epiphysis (HP:0003370)2.65901373
37Abnormality of the common coagulation pathway (HP:0010990)2.64477407
38Abnormality of polysaccharide metabolism (HP:0011012)2.64063262
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64063262
40Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64063262
41Retinal atrophy (HP:0001105)2.61391919
42Trismus (HP:0000211)2.59441081
43Cupped ribs (HP:0000887)2.58652143
44Ankle contracture (HP:0006466)2.55718962
45Flat acetabular roof (HP:0003180)2.55684016
46Pancreatic islet-cell hyperplasia (HP:0004510)2.53105065
47Unilateral renal agenesis (HP:0000122)2.51084490
48Irregular vertebral endplates (HP:0003301)2.50056271
49Insulin resistance (HP:0000855)2.49719750
50Vitreoretinal degeneration (HP:0000655)2.46920049
51Platyspondyly (HP:0000926)2.46917628
52Bladder diverticulum (HP:0000015)2.46491954
53Ketosis (HP:0001946)2.46326889
54Hypoplastic ischia (HP:0003175)2.40897537
55Breech presentation (HP:0001623)2.35954907
56Atrophic scars (HP:0001075)2.33450484
57Abnormality of the umbilical cord (HP:0010881)2.33190713
58Small epiphyses (HP:0010585)2.32452172
59Vertebral compression fractures (HP:0002953)2.31373229
60Wormian bones (HP:0002645)2.31233299
61Abdominal distention (HP:0003270)2.30699069
62Joint stiffness (HP:0001387)2.30076541
63Prolonged partial thromboplastin time (HP:0003645)2.28679658
64Natal tooth (HP:0000695)2.28196129
65Gout (HP:0001997)2.27735568
66Large for gestational age (HP:0001520)2.27351953
67Abnormality of carpal bone ossification (HP:0006257)2.25604641
68Rough bone trabeculation (HP:0100670)2.24655318
69Abnormal protein glycosylation (HP:0012346)2.24105906
70Abnormal glycosylation (HP:0012345)2.24105906
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24105906
72Abnormal protein N-linked glycosylation (HP:0012347)2.24105906
73Osteoarthritis (HP:0002758)2.24047662
74Delayed epiphyseal ossification (HP:0002663)2.23744559
75Abnormality of the vertebral endplates (HP:0005106)2.23366525
76Metaphyseal cupping (HP:0003021)2.22422366
77Overlapping toe (HP:0001845)2.21084854
78Abnormality of the anterior horn cell (HP:0006802)2.21053007
79Degeneration of anterior horn cells (HP:0002398)2.21053007
80Patent foramen ovale (HP:0001655)2.20904154
81Spinal rigidity (HP:0003306)2.20447606
82Congenital glaucoma (HP:0001087)2.20178672
83Abnormal delivery (HP:0001787)2.19361094
84Elbow flexion contracture (HP:0002987)2.18582029
85Ovoid vertebral bodies (HP:0003300)2.18074374
86Abnormal cartilage morphology (HP:0002763)2.17193103
87Abnormality of the ischium (HP:0003174)2.17163791
88Hyperacusis (HP:0010780)2.14804602
89Asymmetry of the thorax (HP:0001555)2.14391247
90Aortic dissection (HP:0002647)2.12357029
91Upper limb muscle weakness (HP:0003484)2.12179254
92Hypoplasia of the odontoid process (HP:0003311)2.10858593
93Right ventricular cardiomyopathy (HP:0011663)2.09692585
94Orthostatic hypotension (HP:0001278)2.09215819
95Hypokinesia (HP:0002375)2.09073938
96Follicular hyperkeratosis (HP:0007502)2.08986247
97Vascular tortuosity (HP:0004948)2.08954535
98Hypoplasia of the pons (HP:0012110)2.04682117
99Flattened epiphyses (HP:0003071)2.04539559
100Abnormality of calcium-phosphate metabolism (HP:0100530)2.03366582
101Insomnia (HP:0100785)2.01499992
102Abnormality of the fetal cardiovascular system (HP:0010948)2.00886045
103Abnormal umbilical cord blood vessels (HP:0011403)2.00886045
104Single umbilical artery (HP:0001195)2.00886045
105Advanced eruption of teeth (HP:0006288)2.00451693
106Fragile skin (HP:0001030)2.00433420
107Disproportionate tall stature (HP:0001519)2.00379695
108Generalized amyotrophy (HP:0003700)2.00025620
109Hand muscle atrophy (HP:0009130)1.99847002
110Multiple enchondromatosis (HP:0005701)1.98988926
111Entropion (HP:0000621)1.98675382
112Microglossia (HP:0000171)1.97388920
113Exocrine pancreatic insufficiency (HP:0001738)1.95320195
114Abnormality of the acetabulum (HP:0003170)1.95207239
115Exostoses (HP:0100777)1.94467774
116Intrahepatic cholestasis (HP:0001406)1.93660256
117Coxa vara (HP:0002812)1.93583247
118Abnormality of the Achilles tendon (HP:0005109)1.93275976
119Arterial tortuosity (HP:0005116)1.92845155
120Disproportionate short-trunk short stature (HP:0003521)1.92369054
121Myopathic facies (HP:0002058)1.91046630
122Blue sclerae (HP:0000592)1.90660917
123Achilles tendon contracture (HP:0001771)1.90089654
124Abnormality of monocarboxylic acid metabolism (HP:0010996)1.89814573
125Back pain (HP:0003418)1.89628788
126Progressive muscle weakness (HP:0003323)1.89206078
127Metaphyseal irregularity (HP:0003025)1.87988856
128Microvesicular hepatic steatosis (HP:0001414)1.87290189
129Renal duplication (HP:0000075)1.86191099
130Severe short stature (HP:0003510)1.86045460
131Soft skin (HP:0000977)1.85511851
132Abnormalities of placenta or umbilical cord (HP:0001194)1.85473296
133Neonatal short-limb short stature (HP:0008921)1.84634082
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.84247399
135Vertebral hypoplasia (HP:0008417)1.83699862
136Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.83699862
137Genu varum (HP:0002970)1.83067322
138Conjugated hyperbilirubinemia (HP:0002908)1.82817039
139Vacuolated lymphocytes (HP:0001922)1.82525261
140Pterygium (HP:0001059)1.82310379
141Long toe (HP:0010511)1.81257734
142Abnormality of the distal phalanges of the toes (HP:0010182)1.81190614
143Hyperparathyroidism (HP:0000843)1.80988459
144Secondary amenorrhea (HP:0000869)1.79909412
145Abnormality of dentin (HP:0010299)1.79689370
146Abnormality of pain sensation (HP:0010832)1.79414405
147Impaired pain sensation (HP:0007328)1.79414405
148Type I transferrin isoform profile (HP:0003642)1.77021326
149Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76850512
150Biconcave vertebral bodies (HP:0004586)1.74113242
151Cardiovascular calcification (HP:0011915)1.73785008
152Mildly elevated creatine phosphokinase (HP:0008180)1.73119126
153Neonatal death (HP:0003811)1.72234623
154Increased nuchal translucency (HP:0010880)1.71958401
155Dilatation of the ascending aorta (HP:0005111)1.71794068
156Abnormality of alkaline phosphatase activity (HP:0004379)1.71520499
157Cerebellar dysplasia (HP:0007033)1.71121309
158Abnormality of purine metabolism (HP:0004352)1.71116209
159Prominent metopic ridge (HP:0005487)1.69743110
160Carpal bone hypoplasia (HP:0001498)1.69666591
161Reduced antithrombin III activity (HP:0001976)1.69484481
162Nonimmune hydrops fetalis (HP:0001790)1.69016415
163Coxa valga (HP:0002673)1.68958223
164Abnormal enzyme/coenzyme activity (HP:0012379)1.68338298
165Osteolytic defects of the phalanges of the hand (HP:0009771)1.68142165
166Osteolytic defects of the hand bones (HP:0009699)1.68142165
167Hyperextensible skin (HP:0000974)1.68062912
168J-shaped sella turcica (HP:0002680)1.68015342
169Elevated alkaline phosphatase (HP:0003155)1.67962986
170Premature skin wrinkling (HP:0100678)1.67917528
171Septate vagina (HP:0001153)1.67732117
172Cholelithiasis (HP:0001081)1.66840261
173Abnormal ossification of hand bones (HP:0005921)1.64856489
174Thin skin (HP:0000963)1.62180961
175Abnormal trabecular bone morphology (HP:0100671)1.60818249
176Sparse eyelashes (HP:0000653)1.60416405
177Delayed closure of the anterior fontanelle (HP:0001476)1.60363940
178Deviation of the thumb (HP:0009603)1.59182113
179Abnormal gallbladder morphology (HP:0012437)1.56052522

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.38224126
2CDK123.59479640
3PASK3.44265166
4TRIB33.41561116
5INSRR3.37889493
6BCKDK3.14257971
7TESK13.12035929
8NEK12.80897143
9TAOK32.77554341
10EIF2AK32.72451202
11FLT32.53774550
12WNK42.28005673
13MAPK152.15057337
14PKN22.11934370
15FRK2.10906906
16SCYL22.08965659
17SMG11.83438162
18VRK21.81907556
19PRKD31.73099318
20MST1R1.70841941
21IRAK31.70772085
22MAP3K21.64225214
23MAP3K31.63408923
24TTK1.59844767
25HIPK21.53994080
26MAP2K21.53039619
27PTK61.50130724
28MAP3K121.45485021
29BRSK21.45268604
30PIK3CG1.43838226
31MAP3K11.42447724
32PTK21.42245858
33TRIM281.39742550
34EPHA31.38716508
35BRD41.37726802
36SRPK11.34119803
37RPS6KA41.33531762
38EPHA21.30523757
39CDK71.30210472
40NME11.28853918
41PBK1.27710626
42SIK11.26998208
43LIMK11.25548112
44TESK21.24509515
45ICK1.23065283
46MET1.22652118
47PIM21.22038354
48SIK31.17911896
49DDR21.16816055
50PDGFRA1.14207146
51NTRK11.14142023
52FER1.12458879
53KSR21.12198200
54TSSK61.10214142
55STK38L1.09015135
56MAP3K111.07363027
57LATS11.03653415
58MAPKAPK31.01785805
59MAP3K91.00482697
60CAMKK20.99058251
61NME20.96936705
62IRAK10.96900647
63CLK10.95505721
64ZAP700.94162203
65PAK30.93103219
66CDC70.89622270
67KDR0.89259138
68EPHB10.89128546
69MAP2K10.86605620
70BCR0.84091289
71LRRK20.81144267
72ERBB40.80947648
73DYRK1B0.79971152
74PRKG20.77655163
75RIPK10.75684206
76MOS0.75467960
77TAOK20.74619258
78MST40.74026735
79RAF10.72428471
80CHEK10.72177012
81PLK40.71868275
82PRKCI0.71679533
83LMTK20.70594765
84PAK20.69413097
85JAK30.69209150
86TAOK10.68339185
87CDK90.67950998
88TTN0.63237307
89DAPK10.62682340
90ACVR1B0.61029220
91PRPF4B0.60794145
92MAP3K80.58900092
93FGFR40.58524071
94NEK90.57429381
95MAPK110.56438936
96FGFR10.56199453
97MTOR0.54849101
98LATS20.54754579
99TBK10.54443914
100BUB10.53860106
101IRAK40.52385044
102ABL20.50757518
103MAP3K100.50301376
104MAPKAPK50.49702102
105ILK0.49695349
106STK380.48949947
107CDK140.48782078
108CDK80.48352208
109ARAF0.48215658
110STK160.48182137
111NLK0.47934733
112AURKB0.47721004
113RET0.47565493
114CDK180.46756604
115CDK11A0.46596368
116PAK40.46356676
117PRKD20.46134557
118CDK150.45686430
119CDC42BPA0.45186693
120BRAF0.43315781
121CAMKK10.39760166
122CHEK20.39244146
123EIF2AK20.38531536
124BRSK10.38444108
125AURKA0.37783541
126TGFBR10.37741239
127TGFBR20.36671747
128MAPKAPK20.36366926
129CDK40.35728709
130WNK30.35175579
131AKT20.34792650
132EIF2AK10.34727556
133RPS6KA20.31902203
134EEF2K0.31133851
135IRAK20.28432557
136GSK3A0.27680443
137STK30.25181828
138PTK2B0.24968588
139DYRK30.24515652
140STK100.24329582
141IGF1R0.22419255
142BTK0.21730139
143PRKD10.20402106
144MAP2K30.20042621
145MYLK0.19979500
146PAK10.18924181
147RPS6KB20.18345384
148ERBB30.17925783

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.96297918
2Protein export_Homo sapiens_hsa030606.42829850
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.44086687
4Sulfur metabolism_Homo sapiens_hsa009203.15990626
5N-Glycan biosynthesis_Homo sapiens_hsa005102.88612860
6Selenocompound metabolism_Homo sapiens_hsa004502.68954590
7Folate biosynthesis_Homo sapiens_hsa007902.31785521
8DNA replication_Homo sapiens_hsa030302.26858876
9Spliceosome_Homo sapiens_hsa030402.07806491
10Base excision repair_Homo sapiens_hsa034102.01873286
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00295847
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.99803079
13Vibrio cholerae infection_Homo sapiens_hsa051101.75922324
14Protein digestion and absorption_Homo sapiens_hsa049741.67773101
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64380216
16RNA transport_Homo sapiens_hsa030131.64305168
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61377451
18Fat digestion and absorption_Homo sapiens_hsa049751.50497637
19Tryptophan metabolism_Homo sapiens_hsa003801.46036786
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43463552
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43042151
22Fatty acid elongation_Homo sapiens_hsa000621.35944666
23Galactose metabolism_Homo sapiens_hsa000521.35622850
24Mismatch repair_Homo sapiens_hsa034301.31419062
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31324535
26Other glycan degradation_Homo sapiens_hsa005111.30800223
27mRNA surveillance pathway_Homo sapiens_hsa030151.29234472
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26590184
29Lysosome_Homo sapiens_hsa041421.26511479
30Cell cycle_Homo sapiens_hsa041101.21102861
31Starch and sucrose metabolism_Homo sapiens_hsa005001.19453042
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18238861
33Nucleotide excision repair_Homo sapiens_hsa034201.14010899
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.12046428
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11006607
36Adherens junction_Homo sapiens_hsa045201.09898956
37Non-homologous end-joining_Homo sapiens_hsa034501.09858334
38Pyrimidine metabolism_Homo sapiens_hsa002401.09845163
39Insulin secretion_Homo sapiens_hsa049111.07798584
40Pancreatic secretion_Homo sapiens_hsa049721.04136396
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98776552
42Fatty acid degradation_Homo sapiens_hsa000710.97731587
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97189073
44Thyroid cancer_Homo sapiens_hsa052160.95655510
45RNA polymerase_Homo sapiens_hsa030200.95114881
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93475031
47Bladder cancer_Homo sapiens_hsa052190.93144541
48Arginine and proline metabolism_Homo sapiens_hsa003300.93127146
49Shigellosis_Homo sapiens_hsa051310.91851273
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.90003812
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.89143483
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89102195
53Type I diabetes mellitus_Homo sapiens_hsa049400.86258348
54Proteasome_Homo sapiens_hsa030500.86249826
55ECM-receptor interaction_Homo sapiens_hsa045120.82610428
56Phenylalanine metabolism_Homo sapiens_hsa003600.81661287
57Insulin resistance_Homo sapiens_hsa049310.80941648
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80672605
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79789671
60Antigen processing and presentation_Homo sapiens_hsa046120.78618318
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78277008
62Regulation of autophagy_Homo sapiens_hsa041400.77784638
63Biosynthesis of amino acids_Homo sapiens_hsa012300.77188202
64One carbon pool by folate_Homo sapiens_hsa006700.77174465
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76366307
66Pyruvate metabolism_Homo sapiens_hsa006200.73486453
67Sulfur relay system_Homo sapiens_hsa041220.67104491
68Carbon metabolism_Homo sapiens_hsa012000.66461097
69Arginine biosynthesis_Homo sapiens_hsa002200.66247549
70Proteoglycans in cancer_Homo sapiens_hsa052050.65003426
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.63810864
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63220877
73Vitamin B6 metabolism_Homo sapiens_hsa007500.63050177
74Legionellosis_Homo sapiens_hsa051340.62321480
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62239067
76Epstein-Barr virus infection_Homo sapiens_hsa051690.61534498
77Lysine degradation_Homo sapiens_hsa003100.61164622
78Steroid biosynthesis_Homo sapiens_hsa001000.60673661
79RNA degradation_Homo sapiens_hsa030180.59970900
80Propanoate metabolism_Homo sapiens_hsa006400.58488236
81Glucagon signaling pathway_Homo sapiens_hsa049220.57710111
82Small cell lung cancer_Homo sapiens_hsa052220.56676851
83Histidine metabolism_Homo sapiens_hsa003400.56538716
84MicroRNAs in cancer_Homo sapiens_hsa052060.55056900
85Fructose and mannose metabolism_Homo sapiens_hsa000510.53792807
86p53 signaling pathway_Homo sapiens_hsa041150.52962733
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52465956
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.51944746
89Thyroid hormone synthesis_Homo sapiens_hsa049180.51836235
90Focal adhesion_Homo sapiens_hsa045100.50841503
91Prion diseases_Homo sapiens_hsa050200.50825667
92Tyrosine metabolism_Homo sapiens_hsa003500.50793898
93Peroxisome_Homo sapiens_hsa041460.49955065
94Pancreatic cancer_Homo sapiens_hsa052120.49113976
95Renin-angiotensin system_Homo sapiens_hsa046140.48552824
96Apoptosis_Homo sapiens_hsa042100.46721296
97Type II diabetes mellitus_Homo sapiens_hsa049300.45954249
98ABC transporters_Homo sapiens_hsa020100.45765773
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45624362
100Acute myeloid leukemia_Homo sapiens_hsa052210.45248064
101Herpes simplex infection_Homo sapiens_hsa051680.44390671
102Pentose phosphate pathway_Homo sapiens_hsa000300.44255643
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42531913
104Prolactin signaling pathway_Homo sapiens_hsa049170.42122244
105Viral carcinogenesis_Homo sapiens_hsa052030.40970388
106TGF-beta signaling pathway_Homo sapiens_hsa043500.40858929
107Linoleic acid metabolism_Homo sapiens_hsa005910.39751100
108Butanoate metabolism_Homo sapiens_hsa006500.39741474
109Glutathione metabolism_Homo sapiens_hsa004800.39653412
110Hepatitis B_Homo sapiens_hsa051610.38543399
111Metabolic pathways_Homo sapiens_hsa011000.36567070
112Fatty acid metabolism_Homo sapiens_hsa012120.35448738
113Purine metabolism_Homo sapiens_hsa002300.35012999
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34523364
115Basal transcription factors_Homo sapiens_hsa030220.32929323
116Insulin signaling pathway_Homo sapiens_hsa049100.32660444
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.32599007
118Non-small cell lung cancer_Homo sapiens_hsa052230.32301952
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32297551
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31908088
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31827018
122Complement and coagulation cascades_Homo sapiens_hsa046100.27802514
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27421982
124AMPK signaling pathway_Homo sapiens_hsa041520.26945637
125Caffeine metabolism_Homo sapiens_hsa002320.25642066
126Circadian rhythm_Homo sapiens_hsa047100.24449311
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23494255
128Sphingolipid metabolism_Homo sapiens_hsa006000.23413738
129Prostate cancer_Homo sapiens_hsa052150.22716233
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21538997
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21379658
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.20719568
133Amoebiasis_Homo sapiens_hsa051460.18661654
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17852981
135Cocaine addiction_Homo sapiens_hsa050300.17454534
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17396625
137Chronic myeloid leukemia_Homo sapiens_hsa052200.17046960

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