GOSR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.19343379
2proteasome assembly (GO:0043248)6.13525919
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.73207405
4COPII vesicle coating (GO:0048208)5.30208011
5* activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.25993919
6* positive regulation of nuclease activity (GO:0032075)5.07948762
7protein retention in ER lumen (GO:0006621)4.99489325
8vesicle coating (GO:0006901)4.84352005
9* regulation of nuclease activity (GO:0032069)4.67359041
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.66986786
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66986786
12* endoplasmic reticulum unfolded protein response (GO:0030968)4.56050349
13signal peptide processing (GO:0006465)4.48268710
14* cellular response to unfolded protein (GO:0034620)4.40200392
15* ER-nucleus signaling pathway (GO:0006984)4.21590534
16* cellular response to topologically incorrect protein (GO:0035967)4.19383654
17cullin deneddylation (GO:0010388)4.18143009
18regulation of cellular amino acid metabolic process (GO:0006521)4.12912986
19antigen processing and presentation of endogenous antigen (GO:0019883)4.12156618
20protein deneddylation (GO:0000338)4.11128420
21ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.05803161
22ribosome assembly (GO:0042255)4.05130987
23DNA double-strand break processing (GO:0000729)3.99618047
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.99333292
25protein maturation by protein folding (GO:0022417)3.93369781
26sequestering of metal ion (GO:0051238)3.92862623
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.92148176
28alpha-linolenic acid metabolic process (GO:0036109)3.87773159
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.86008459
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.83298280
31macroautophagy (GO:0016236)3.83141349
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.78112191
33signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.78112191
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75218647
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75218647
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75218647
374-hydroxyproline metabolic process (GO:0019471)3.74545417
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.70069592
39negative regulation of ligase activity (GO:0051352)3.70069592
40nucleotide-sugar biosynthetic process (GO:0009226)3.68315195
41signal transduction involved in DNA integrity checkpoint (GO:0072401)3.64685997
42signal transduction involved in DNA damage checkpoint (GO:0072422)3.64685997
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.62934838
44* response to endoplasmic reticulum stress (GO:0034976)3.59514613
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.59004133
46positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.56114337
47tricarboxylic acid cycle (GO:0006099)3.50920321
48tricarboxylic acid metabolic process (GO:0072350)3.47860342
49regulation of translation in response to stress (GO:0043555)3.45770757
50* response to unfolded protein (GO:0006986)3.36714419
51positive regulation of ligase activity (GO:0051351)3.34912063
52valine metabolic process (GO:0006573)3.26777936
53* response to topologically incorrect protein (GO:0035966)3.25421405
54IMP biosynthetic process (GO:0006188)3.24653831
55mitochondrial DNA replication (GO:0006264)3.22802075
56Golgi organization (GO:0007030)3.21741325
57GDP-mannose metabolic process (GO:0019673)3.19721407
58regulation of ubiquitin-protein transferase activity (GO:0051438)3.18941378
59L-alpha-amino acid transmembrane transport (GO:1902475)3.17525265
60regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.17309895
61mitochondrial RNA metabolic process (GO:0000959)3.15418280
62apoptotic cell clearance (GO:0043277)3.15032115
63low-density lipoprotein particle clearance (GO:0034383)3.14981209
64ER overload response (GO:0006983)3.14486688
65rRNA modification (GO:0000154)3.12882837
66tRNA aminoacylation for protein translation (GO:0006418)3.10837553
67dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.10599886
68endocrine pancreas development (GO:0031018)3.09567411
69proline biosynthetic process (GO:0006561)3.07740853
70peptidyl-asparagine modification (GO:0018196)3.07589313
71* ER to Golgi vesicle-mediated transport (GO:0006888)3.07081440
72amino acid activation (GO:0043038)3.04944686
73tRNA aminoacylation (GO:0043039)3.04944686
74protein N-linked glycosylation via asparagine (GO:0018279)3.04647090
75regulation of ligase activity (GO:0051340)3.02646592
76peptide hormone processing (GO:0016486)2.99965485
77rRNA methylation (GO:0031167)2.99628969
78nucleobase-containing small molecule interconversion (GO:0015949)2.97718934
79L-phenylalanine catabolic process (GO:0006559)2.97438573
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97438573
81mitotic metaphase plate congression (GO:0007080)2.96773926
82UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95790768
83DNA catabolic process, exonucleolytic (GO:0000738)2.92842181
84peptidyl-histidine modification (GO:0018202)2.91275746
85establishment of viral latency (GO:0019043)2.90929561
86regulation of cellular amine metabolic process (GO:0033238)2.88045008
87chaperone-mediated protein transport (GO:0072321)2.86713919
88intra-Golgi vesicle-mediated transport (GO:0006891)2.86406293
89ventricular cardiac muscle cell development (GO:0055015)2.85803823
90positive regulation of cell cycle arrest (GO:0071158)2.85569660
91exocrine pancreas development (GO:0031017)2.84378776
92activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.83813934
93DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82671621
94regulation of mitochondrial translation (GO:0070129)2.82595361
95L-phenylalanine metabolic process (GO:0006558)2.82515042
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82515042
97IMP metabolic process (GO:0046040)2.81718458
98tRNA methylation (GO:0030488)2.80968825
99growth hormone receptor signaling pathway (GO:0060396)2.80339927
100regulation of cholesterol homeostasis (GO:2000188)2.80291902
101protein targeting to mitochondrion (GO:0006626)2.80049062
102protein N-linked glycosylation (GO:0006487)2.79179495
103lysine metabolic process (GO:0006553)2.78790275
104lysine catabolic process (GO:0006554)2.78790275
105antigen processing and presentation via MHC class Ib (GO:0002475)2.78679550
106sexual reproduction (GO:0019953)2.77367215
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77248862
108peptide catabolic process (GO:0043171)2.76275647
109mitochondrial DNA metabolic process (GO:0032042)2.75967421
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73982246
111intestinal cholesterol absorption (GO:0030299)2.73947257
112metaphase plate congression (GO:0051310)2.70058258
113transcription from mitochondrial promoter (GO:0006390)2.69229574
114regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.68164791
115nucleotide-sugar metabolic process (GO:0009225)2.66996560
116pteridine-containing compound biosynthetic process (GO:0042559)2.66872877
117type B pancreatic cell development (GO:0003323)2.65992651
118inner mitochondrial membrane organization (GO:0007007)2.65416951
119positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64816333
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64788642
121lactate metabolic process (GO:0006089)2.63951488
122fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.63766126
123negative regulation of protein ubiquitination (GO:0031397)2.63654921
124respiratory chain complex IV assembly (GO:0008535)2.62427177
1252-oxoglutarate metabolic process (GO:0006103)2.61632243
126negative regulation of fibrinolysis (GO:0051918)2.59815151
127regulation of type B pancreatic cell apoptotic process (GO:2000674)2.58592193
128oxaloacetate metabolic process (GO:0006107)2.58576158
129sulfur amino acid catabolic process (GO:0000098)2.58541101
130peptidyl-proline hydroxylation (GO:0019511)2.58515508
131peptidyl-glutamic acid carboxylation (GO:0017187)2.57643516
132protein carboxylation (GO:0018214)2.57643516
133regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.56599430
134positive regulation of glycolytic process (GO:0045821)2.55028897
135DNA replication checkpoint (GO:0000076)2.54286640
136cellular zinc ion homeostasis (GO:0006882)2.54170963
137telomere maintenance via semi-conservative replication (GO:0032201)2.54144062
138positive regulation of histone deacetylation (GO:0031065)2.53487254
139establishment of integrated proviral latency (GO:0075713)2.53083676
140JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52986452
141negative regulation of cell cycle G1/S phase transition (GO:1902807)2.52278351
142negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.52278351
143regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.51616478
144signal transduction in response to DNA damage (GO:0042770)2.50771910
145antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.50596373
146G1/S transition of mitotic cell cycle (GO:0000082)2.50539496
147cell cycle G1/S phase transition (GO:0044843)2.50539496
148cellular response to vitamin D (GO:0071305)2.50148880
149peroxisome fission (GO:0016559)2.49677302
150regulation of cholesterol storage (GO:0010885)2.49660005
151cellular response to growth hormone stimulus (GO:0071378)2.49237652
152nucleoside salvage (GO:0043174)2.48288728
153purine nucleobase biosynthetic process (GO:0009113)2.48022921
154pseudouridine synthesis (GO:0001522)2.47932966
155branched-chain amino acid catabolic process (GO:0009083)2.47596961
156positive regulation of fatty acid biosynthetic process (GO:0045723)2.47455440
157folic acid-containing compound biosynthetic process (GO:0009396)2.47305618
158protein localization to mitochondrion (GO:0070585)2.47118213
159negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.46516995
160regulation of fatty acid beta-oxidation (GO:0031998)2.46418443
161formation of translation preinitiation complex (GO:0001731)2.44731501
162double-strand break repair via nonhomologous end joining (GO:0006303)2.44513066
163non-recombinational repair (GO:0000726)2.44513066
164regulation of metalloenzyme activity (GO:0048552)2.43051590
165* Golgi vesicle transport (GO:0048193)2.42734536
166establishment of protein localization to mitochondrion (GO:0072655)2.41670348
167regulation of cofactor metabolic process (GO:0051193)2.41523354
168intestinal absorption (GO:0050892)2.40279509
169triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40226742
170cellular response to nutrient (GO:0031670)2.39181973
171keratan sulfate catabolic process (GO:0042340)2.39093985
172plasma lipoprotein particle clearance (GO:0034381)2.33696235
173cellular response to vitamin (GO:0071295)2.33034169
174localization within membrane (GO:0051668)2.32352542
175stress fiber assembly (GO:0043149)2.29458862
176killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.29054980
177disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.29054980
178transcytosis (GO:0045056)2.27988166
179pentose-phosphate shunt (GO:0006098)2.25358194
180regulation of membrane protein ectodomain proteolysis (GO:0051043)2.25267260
181NADPH regeneration (GO:0006740)2.24898836
182glyoxylate metabolic process (GO:0046487)2.22924780
183regulation of gamma-delta T cell differentiation (GO:0045586)2.21940992
184negative regulation of lipid transport (GO:0032369)2.17993298
185complement activation, alternative pathway (GO:0006957)2.17524543
186cell redox homeostasis (GO:0045454)2.17241294
187negative regulation of glycoprotein biosynthetic process (GO:0010561)2.15128754
188negative regulation of bone resorption (GO:0045779)2.14812805
189Golgi transport vesicle coating (GO:0048200)10.4084764
190COPI coating of Golgi vesicle (GO:0048205)10.4084764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.25798046
2E2F7_22180533_ChIP-Seq_HELA_Human4.65876955
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.49104036
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.10164648
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.85214035
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.64077423
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.52679010
8* EST1_17652178_ChIP-ChIP_JURKAT_Human3.43271982
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.32340550
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.24547260
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.20977727
12RXR_22158963_ChIP-Seq_LIVER_Mouse3.17842853
13PPARA_22158963_ChIP-Seq_LIVER_Mouse3.16329626
14IRF8_22096565_ChIP-ChIP_GC-B_Human3.03610138
15EGR1_19374776_ChIP-ChIP_THP-1_Human3.03439680
16ETS1_20019798_ChIP-Seq_JURKAT_Human3.02494100
17CLOCK_20551151_ChIP-Seq_293T_Human3.01331745
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92574251
19GATA1_22025678_ChIP-Seq_K562_Human2.81182613
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.74919167
21ELK1_19687146_ChIP-ChIP_HELA_Human2.66901133
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54516889
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53795359
24* DCP1A_22483619_ChIP-Seq_HELA_Human2.52253360
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.51669518
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51402362
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40200492
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.34168756
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33460954
30* VDR_23849224_ChIP-Seq_CD4+_Human2.29720771
31* GABP_19822575_ChIP-Seq_HepG2_Human2.24855658
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23062431
33MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21085420
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18706211
35AR_21909140_ChIP-Seq_LNCAP_Human2.14461795
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13513583
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.13409336
38MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13373285
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08782808
40FOXP3_21729870_ChIP-Seq_TREG_Human2.05325580
41E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05157765
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03518078
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98932692
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97785719
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.96798745
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96642267
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95561634
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93989027
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.92036758
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91181489
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85271901
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83386179
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82185562
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79602821
55MYC_22102868_ChIP-Seq_BL_Human1.77508919
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77284844
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.76902478
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71383058
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70622798
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.68362812
61* IRF8_27001747_Chip-Seq_BMDM_Mouse1.68302384
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68058871
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66565085
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66505055
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59800893
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59647483
67TFEB_21752829_ChIP-Seq_HELA_Human1.58981190
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56732713
69* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56059871
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54029454
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52543849
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51723213
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51219964
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49424993
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48709871
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48691417
77VDR_21846776_ChIP-Seq_THP-1_Human1.46706036
78MYB_26560356_Chip-Seq_TH2_Human1.46086293
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.40727584
80SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40295031
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39509792
82KDM5A_27292631_Chip-Seq_BREAST_Human1.38271753
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38148167
84* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37783735
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37433562
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.37217666
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35564103
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35117530
89XRN2_22483619_ChIP-Seq_HELA_Human1.35106975
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34986152
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.34669075
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34095273
93* UTX_26944678_Chip-Seq_JUKART_Human1.34024339
94MAF_26560356_Chip-Seq_TH1_Human1.33474030
95TTF2_22483619_ChIP-Seq_HELA_Human1.32494252
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.32392825
97LXR_22292898_ChIP-Seq_THP-1_Human1.30437651
98GATA3_27048872_Chip-Seq_THYMUS_Human1.29678073
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29047605
100TCF7_22412390_ChIP-Seq_EML_Mouse1.28295411
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27614487
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27123823
103* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26512019
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25913363
105* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25912742
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.25848621
107VDR_24763502_ChIP-Seq_THP-1_Human1.25243831
108SOX17_20123909_ChIP-Seq_XEN_Mouse1.24651411
109* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23624513
110* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23540808
111KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22351491
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21514895
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20178219
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19080656
115E2F1_21310950_ChIP-Seq_MCF-7_Human1.18949290
116MYB_26560356_Chip-Seq_TH1_Human1.18612267
117EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17156303
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16519504
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15200023
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14154047
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11939707
122SPI1_23127762_ChIP-Seq_K562_Human1.11498215
123FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11088249
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09469294
125KDM2B_26808549_Chip-Seq_DND41_Human1.09407708
126TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09353916
127* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08927483
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08024193
129NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07484369
130* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07113616
131GATA4_21415370_ChIP-Seq_HL-1_Mouse1.06715760
132ESR1_21235772_ChIP-Seq_MCF-7_Human1.05779285
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05163245
134SPI1_23547873_ChIP-Seq_NB4_Human1.04832471
135* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03995815
136STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03482519
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02652111
138CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02133330
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02040279
140SMAD_19615063_ChIP-ChIP_OVARY_Human1.01934828
141NOTCH1_21737748_ChIP-Seq_TLL_Human1.01914768
142RACK7_27058665_Chip-Seq_MCF-7_Human1.01884601
143GATA1_19941826_ChIP-Seq_K562_Human1.01852650
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01671058
145TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00647237
146FOXM1_23109430_ChIP-Seq_U2OS_Human1.00333342
147FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00333264
148RUNX1_22412390_ChIP-Seq_EML_Mouse0.99979045
149ATF3_27146783_Chip-Seq_COLON_Human0.99943628
150ZNF263_19887448_ChIP-Seq_K562_Human0.99828969
151PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98511261
152NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98444166
153* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97818523
154EOMES_21245162_ChIP-Seq_HESCs_Human0.97210269
155BRD4_25478319_ChIP-Seq_HGPS_Human0.96981517
156TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96539403
157FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96020667
158GATA3_26560356_Chip-Seq_TH2_Human0.95775905
159TBX20_22328084_ChIP-Seq_HEART_Mouse0.95749735
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.95749735
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95730995
162* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95287320
163PU_27001747_Chip-Seq_BMDM_Mouse0.95203800
164FOXA2_19822575_ChIP-Seq_HepG2_Human0.94966641
165SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92866722
166SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91092686
167Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90700975
168GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89632536
169NCOR1_26117541_ChIP-Seq_K562_Human0.89512326
170* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89090522
171CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88530288
172KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88525681
173* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87887913
174MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83960909
175MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.82782551
176SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82066555
177STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80433789
178MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78803515
179FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78351271
180VDR_22108803_ChIP-Seq_LS180_Human0.78307163
181HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78078008
182ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76757970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.21633637
2MP0002877_abnormal_melanocyte_morpholog3.12310620
3MP0009697_abnormal_copulation2.99552253
4MP0009840_abnormal_foam_cell2.89843640
5MP0003300_gastrointestinal_ulcer2.85693310
6MP0008058_abnormal_DNA_repair2.82846835
7MP0005058_abnormal_lysosome_morphology2.76907514
8MP0004957_abnormal_blastocyst_morpholog2.74687645
9MP0003705_abnormal_hypodermis_morpholog2.73629462
10MP0008438_abnormal_cutaneous_collagen2.72070831
11MP0003786_premature_aging2.64149595
12MP0000013_abnormal_adipose_tissue2.61083556
13MP0006054_spinal_hemorrhage2.52759107
14MP0003186_abnormal_redox_activity2.52390429
15MP0003195_calcinosis2.49943679
16MP0005360_urolithiasis2.44437037
17MP0005365_abnormal_bile_salt2.43628946
18MP0009780_abnormal_chondrocyte_physiolo2.36676749
19MP0010094_abnormal_chromosome_stability2.33386179
20MP0004272_abnormal_basement_membrane2.30791225
21MP0003718_maternal_effect2.21094814
22MP0008260_abnormal_autophagy2.18623569
23MP0002909_abnormal_adrenal_gland2.12982176
24MP0008932_abnormal_embryonic_tissue2.12545205
25MP0005451_abnormal_body_composition2.10628921
26MP0003693_abnormal_embryo_hatching2.09118006
27MP0003183_abnormal_peptide_metabolism2.07619854
28MP0003111_abnormal_nucleus_morphology2.06909365
29MP0003172_abnormal_lysosome_physiology2.01290788
30MP0003077_abnormal_cell_cycle2.00449734
31MP0003950_abnormal_plasma_membrane2.00163477
32MP0002693_abnormal_pancreas_physiology1.91289566
33MP0004043_abnormal_pH_regulation1.89718826
34MP0001666_abnormal_nutrient_absorption1.87462473
35MP0003252_abnormal_bile_duct1.87070074
36MP0003191_abnormal_cellular_cholesterol1.86542025
37MP0008007_abnormal_cellular_replicative1.84556795
38MP0010386_abnormal_urinary_bladder1.81663251
39MP0008057_abnormal_DNA_replication1.80066242
40MP0003303_peritoneal_inflammation1.74557209
41MP0001944_abnormal_pancreas_morphology1.73767354
42MP0005220_abnormal_exocrine_pancreas1.72539157
43MP0003436_decreased_susceptibility_to1.70852373
44MP0005085_abnormal_gallbladder_physiolo1.68592802
45MP0010329_abnormal_lipoprotein_level1.60241718
46MP0000358_abnormal_cell_content/1.59502769
47MP0001730_embryonic_growth_arrest1.55807505
48MP0009643_abnormal_urine_homeostasis1.55284507
49MP0000609_abnormal_liver_physiology1.52913166
50MP0006036_abnormal_mitochondrial_physio1.51900741
51MP0001764_abnormal_homeostasis1.50820513
52MP0008961_abnormal_basal_metabolism1.49026679
53MP0002138_abnormal_hepatobiliary_system1.47344002
54MP0003283_abnormal_digestive_organ1.46301509
55MP0006035_abnormal_mitochondrial_morpho1.41357521
56MP0000685_abnormal_immune_system1.38273192
57MP0002078_abnormal_glucose_homeostasis1.36971850
58MP0001533_abnormal_skeleton_physiology1.35270218
59MP0001835_abnormal_antigen_presentation1.32103377
60MP0010352_gastrointestinal_tract_polyps1.31422899
61MP0005083_abnormal_biliary_tract1.28944933
62MP0004130_abnormal_muscle_cell1.28726721
63MP0008995_early_reproductive_senescence1.28220207
64MP0003941_abnormal_skin_development1.27167560
65MP0000604_amyloidosis1.24967757
66MP0000372_irregular_coat_pigmentation1.24314100
67MP0002118_abnormal_lipid_homeostasis1.21135684
68MP0004264_abnormal_extraembryonic_tissu1.20683600
69MP0003566_abnormal_cell_adhesion1.20509427
70MP0008875_abnormal_xenobiotic_pharmacok1.20064103
71MP0004947_skin_inflammation1.19813693
72MP0000003_abnormal_adipose_tissue1.18780588
73MP0000538_abnormal_urinary_bladder1.17757618
74MP0002896_abnormal_bone_mineralization1.17607354
75MP0001756_abnormal_urination1.17011553
76MP0005395_other_phenotype1.15724848
77MP0008789_abnormal_olfactory_epithelium1.15069511
78MP0005367_renal/urinary_system_phenotyp1.15042622
79MP0000516_abnormal_urinary_system1.15042622
80MP0003279_aneurysm1.14947299
81MP0003656_abnormal_erythrocyte_physiolo1.13432148
82MP0005076_abnormal_cell_differentiation1.11980547
83MP0005275_abnormal_skin_tensile1.11702761
84MP0003806_abnormal_nucleotide_metabolis1.10447354
85MP0002419_abnormal_innate_immunity1.10057354
86MP0005000_abnormal_immune_tolerance1.08979530
87MP0004233_abnormal_muscle_weight1.08780423
88MP0001727_abnormal_embryo_implantation1.08046361
89MP0002332_abnormal_exercise_endurance1.06500582
90MP0005464_abnormal_platelet_physiology1.06291331
91MP0002080_prenatal_lethality1.05549754
92MP0002102_abnormal_ear_morphology1.05259349
93MP0002166_altered_tumor_susceptibility1.05213189
94MP0005332_abnormal_amino_acid1.04766437
95MP0005408_hypopigmentation1.04729368
96MP0005623_abnormal_meninges_morphology1.04712372
97MP0004147_increased_porphyrin_level1.04211210
98MP0001672_abnormal_embryogenesis/_devel1.03598499
99MP0005380_embryogenesis_phenotype1.03598499
100MP0010368_abnormal_lymphatic_system1.03482880
101MP0001845_abnormal_inflammatory_respons1.02576237
102MP0000749_muscle_degeneration1.02554236
103MP0001697_abnormal_embryo_size1.02198137
104MP0000598_abnormal_liver_morphology1.02180400
105MP0005319_abnormal_enzyme/_coenzyme1.01550475
106MP0008469_abnormal_protein_level1.00311544
107MP0003984_embryonic_growth_retardation0.98674991
108MP0005023_abnormal_wound_healing0.98626895
109MP0001529_abnormal_vocalization0.97588755
110MP0005387_immune_system_phenotype0.97100105
111MP0001790_abnormal_immune_system0.97100105
112MP0002295_abnormal_pulmonary_circulatio0.95740086
113MP0005384_cellular_phenotype0.95597341
114MP0000350_abnormal_cell_proliferation0.95259542
115MP0001542_abnormal_bone_strength0.95241045
116MP0005621_abnormal_cell_physiology0.93498681
117MP0002088_abnormal_embryonic_growth/wei0.93237523
118MP0006082_CNS_inflammation0.92750182
119MP0005266_abnormal_metabolism0.91924352
120MP0005330_cardiomyopathy0.91767366
121MP0001958_emphysema0.91196262
122MP0003868_abnormal_feces_composition0.90002350
123MP0002933_joint_inflammation0.88620426
124MP0001243_abnormal_dermal_layer0.87590326
125MP0001765_abnormal_ion_homeostasis0.87199552
126MP0003795_abnormal_bone_structure0.87193246
127MP0001661_extended_life_span0.86781454
128MP0002269_muscular_atrophy0.86381325
129MP0002086_abnormal_extraembryonic_tissu0.86135612
130MP0003724_increased_susceptibility_to0.86123474
131MP0002998_abnormal_bone_remodeling0.85670506
132MP0002060_abnormal_skin_morphology0.84970738
133MP0004215_abnormal_myocardial_fiber0.84435791
134MP0005671_abnormal_response_to0.83720596
135MP0010234_abnormal_vibrissa_follicle0.82411646
136MP0003091_abnormal_cell_migration0.81577471
137MP0005375_adipose_tissue_phenotype0.81489874
138MP0002928_abnormal_bile_duct0.81484520
139MP0005025_abnormal_response_to0.80241301
140MP0004185_abnormal_adipocyte_glucose0.79742087
141MP0009785_altered_susceptibility_to0.79474287
142MP0009384_cardiac_valve_regurgitation0.79055442
143MP0005584_abnormal_enzyme/coenzyme_acti0.78708488
144MP0005636_abnormal_mineral_homeostasis0.78235107
145MP0005310_abnormal_salivary_gland0.77448495
146MP0005376_homeostasis/metabolism_phenot0.77444743
147MP0002723_abnormal_immune_serum0.77402328
148MP0002084_abnormal_developmental_patter0.77345829
149MP0005379_endocrine/exocrine_gland_phen0.76758841
150MP0002452_abnormal_antigen_presenting0.76070309
151MP0005670_abnormal_white_adipose0.75386486
152MP0001915_intracranial_hemorrhage0.75124123
153MP0000313_abnormal_cell_death0.74983055
154MP0009642_abnormal_blood_homeostasis0.74325402
155MP0003959_abnormal_lean_body0.73938806
156MP0003075_altered_response_to0.73522250
157MP0010307_abnormal_tumor_latency0.73258571
158MP0001929_abnormal_gametogenesis0.72790961
159MP0002132_abnormal_respiratory_system0.72086671
160MP0002420_abnormal_adaptive_immunity0.71957925
161MP0001819_abnormal_immune_cell0.71629199
162MP0005197_abnormal_uvea_morphology0.70409666
163MP0005084_abnormal_gallbladder_morpholo0.69896144
164MP0003221_abnormal_cardiomyocyte_apopto0.69826276
165MP0002837_dystrophic_cardiac_calcinosis0.69456424
166MP0010030_abnormal_orbit_morphology0.67601131
167MP0005410_abnormal_fertilization0.67248968

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.16877659
2Hyperinsulinemic hypoglycemia (HP:0000825)3.72183349
3Abnormality of glycolysis (HP:0004366)3.65078482
4Increased serum pyruvate (HP:0003542)3.54789939
5Urinary glycosaminoglycan excretion (HP:0003541)3.51773223
6Mucopolysacchariduria (HP:0008155)3.51773223
7Hypoglycemic seizures (HP:0002173)3.42679455
8Abnormal gallbladder physiology (HP:0012438)3.41273817
9Cholecystitis (HP:0001082)3.41273817
10Type I transferrin isoform profile (HP:0003642)3.23679783
11Abnormality of mucopolysaccharide metabolism (HP:0011020)3.18176479
12Abnormality of polysaccharide metabolism (HP:0011012)3.18176479
13Abnormality of glycosaminoglycan metabolism (HP:0004371)3.18176479
14Dysostosis multiplex (HP:0000943)3.17526646
15Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.08229321
16Abnormal protein N-linked glycosylation (HP:0012347)3.08229321
17Abnormal protein glycosylation (HP:0012346)3.08229321
18Abnormal glycosylation (HP:0012345)3.08229321
19Abnormality of the intrinsic pathway (HP:0010989)3.07132089
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.06668786
21Increased cerebral lipofuscin (HP:0011813)3.00157031
22Ketoacidosis (HP:0001993)2.97102824
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.95721579
24Deep venous thrombosis (HP:0002625)2.92883681
25Abnormality of the pancreatic islet cells (HP:0006476)2.92863993
26Abnormality of endocrine pancreas physiology (HP:0012093)2.92863993
27Entropion (HP:0000621)2.91354078
28Reduced antithrombin III activity (HP:0001976)2.88150959
29Abnormality of the common coagulation pathway (HP:0010990)2.84604982
30Cerebral aneurysm (HP:0004944)2.84482263
31Secondary amenorrhea (HP:0000869)2.81602567
32Microvesicular hepatic steatosis (HP:0001414)2.76676528
33Acute encephalopathy (HP:0006846)2.75050485
34Late onset (HP:0003584)2.69526173
35Hepatic necrosis (HP:0002605)2.69357801
36Xanthomatosis (HP:0000991)2.66231408
37Hyperglycemia (HP:0003074)2.65622864
38Premature ovarian failure (HP:0008209)2.62477052
39Hepatocellular necrosis (HP:0001404)2.61785830
40Abnormality of methionine metabolism (HP:0010901)2.57466201
41Abnormal mitochondria in muscle tissue (HP:0008316)2.56441218
42Pancreatic islet-cell hyperplasia (HP:0004510)2.55749784
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.54352144
44Acute necrotizing encephalopathy (HP:0006965)2.53577396
45Ketosis (HP:0001946)2.52647379
46Increased CSF lactate (HP:0002490)2.51579599
47Peritonitis (HP:0002586)2.46558384
48Symptomatic seizures (HP:0011145)2.46383665
49Abnormal umbilical cord blood vessels (HP:0011403)2.46146035
50Single umbilical artery (HP:0001195)2.46146035
51Abnormality of the fetal cardiovascular system (HP:0010948)2.46146035
52Protrusio acetabuli (HP:0003179)2.42646133
53Increased serum lactate (HP:0002151)2.41768914
54Cerebral hypomyelination (HP:0006808)2.36151164
55Nonimmune hydrops fetalis (HP:0001790)2.32883292
56Premature rupture of membranes (HP:0001788)2.31716279
57Abnormality of the umbilical cord (HP:0010881)2.30091135
58Proximal tubulopathy (HP:0000114)2.29725429
59Insulin-resistant diabetes mellitus (HP:0000831)2.28668117
60Progressive macrocephaly (HP:0004481)2.28434502
61Complement deficiency (HP:0004431)2.27350561
62Hand muscle atrophy (HP:0009130)2.27340930
63Lactic acidosis (HP:0003128)2.26429114
64Long toe (HP:0010511)2.25882662
65Papilledema (HP:0001085)2.25734630
66Mitral stenosis (HP:0001718)2.25489709
67Rough bone trabeculation (HP:0100670)2.23659233
68Abnormality of the anterior horn cell (HP:0006802)2.22891712
69Degeneration of anterior horn cells (HP:0002398)2.22891712
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.21458791
71Generalized aminoaciduria (HP:0002909)2.20799999
72Recurrent gram-negative bacterial infections (HP:0005420)2.20121021
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.17887983
74Cerebral edema (HP:0002181)2.17500440
75Metaphyseal cupping (HP:0003021)2.16266375
76Upper limb muscle weakness (HP:0003484)2.16130430
77Postnatal microcephaly (HP:0005484)2.15454624
78Abnormalities of placenta or umbilical cord (HP:0001194)2.14886465
79Mitochondrial inheritance (HP:0001427)2.14573053
80Cholelithiasis (HP:0001081)2.14286914
81Asymmetric septal hypertrophy (HP:0001670)2.14123365
82Hypobetalipoproteinemia (HP:0003563)2.13249326
83Polycythemia (HP:0001901)2.13005186
84Cervical subluxation (HP:0003308)2.12706393
85Orthostatic hypotension (HP:0001278)2.11499090
86Intrahepatic cholestasis (HP:0001406)2.11345852
87Abnormality of the nasal mucosa (HP:0000433)2.10719256
88Ependymoma (HP:0002888)2.09702245
89CNS demyelination (HP:0007305)2.09511280
90Nasal polyposis (HP:0100582)2.08090616
91Systemic lupus erythematosus (HP:0002725)2.07135871
92Eczematoid dermatitis (HP:0000976)2.07111985
93Gout (HP:0001997)2.06779431
94Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05386145
95Global brain atrophy (HP:0002283)2.03926722
96Hypokinesia (HP:0002375)2.03352065
97Hematochezia (HP:0002573)2.02525791
98Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02462535
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02345202
100Abnormality of purine metabolism (HP:0004352)2.02163148
101Large for gestational age (HP:0001520)2.00918977
102Retinal atrophy (HP:0001105)2.00455898
103Upper limb amyotrophy (HP:0009129)2.00143087
104Distal upper limb amyotrophy (HP:0007149)2.00143087
105Skin nodule (HP:0200036)2.00010391
106Aneurysm (HP:0002617)1.99023369
107Interstitial pulmonary disease (HP:0006530)1.97481436
108Thoracolumbar scoliosis (HP:0002944)1.97443852
109Renal Fanconi syndrome (HP:0001994)1.96203243
110Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96138735
111Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96138735
112Autoimmune thrombocytopenia (HP:0001973)1.95855640
113Dicarboxylic aciduria (HP:0003215)1.94065897
114Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94065897
115Vacuolated lymphocytes (HP:0001922)1.93152527
116Slender build (HP:0001533)1.92578443
117Insulin resistance (HP:0000855)1.91639621
118Exercise intolerance (HP:0003546)1.90595520
119Cutaneous melanoma (HP:0012056)1.89923971
120Abnormality of fatty-acid metabolism (HP:0004359)1.88999305
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88690080
122Dilatation of the ascending aorta (HP:0005111)1.87589714
123Abnormality of the metopic suture (HP:0005556)1.87410349
124Hypothermia (HP:0002045)1.87301792
125Protuberant abdomen (HP:0001538)1.87244586
126Striae distensae (HP:0001065)1.84924051
127Vertebral compression fractures (HP:0002953)1.83751293
128Reduced subcutaneous adipose tissue (HP:0003758)1.83306417
129Resting tremor (HP:0002322)1.83020551
130Thrombocytosis (HP:0001894)1.82762707
131CNS hypomyelination (HP:0003429)1.80457866
132Respiratory failure (HP:0002878)1.79600703
133Abnormal trabecular bone morphology (HP:0100671)1.79486920
134Hyperammonemia (HP:0001987)1.79199518
135Myocardial infarction (HP:0001658)1.79157663
136Autoamputation (HP:0001218)1.79098292
137Nausea (HP:0002018)1.78499501
138Exertional dyspnea (HP:0002875)1.77990331
139Thin bony cortex (HP:0002753)1.77890364
140Fatigue (HP:0012378)1.77849304
141Shoulder girdle muscle weakness (HP:0003547)1.77196854
142Glucose intolerance (HP:0000833)1.76580299
143Increased CSF protein (HP:0002922)1.76428006
144Lethargy (HP:0001254)1.75243499
145Hypoalphalipoproteinemia (HP:0003233)1.74754814
146Prominent metopic ridge (HP:0005487)1.73566451
147Aortic aneurysm (HP:0004942)1.72638861
148Opisthotonus (HP:0002179)1.72366375
149Chromsome breakage (HP:0040012)1.71718355
150Osteolytic defects of the hand bones (HP:0009699)1.71688944
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.71688944
152Severe short stature (HP:0003510)1.71428242
153Loss of speech (HP:0002371)1.71267760
154Tongue fasciculations (HP:0001308)1.71249873
155Sensorimotor neuropathy (HP:0007141)1.71122989
156Abnormality of pyrimidine metabolism (HP:0004353)1.70285531
157Abnormality of glycosphingolipid metabolism (HP:0004343)1.69474072
158Abnormality of glycolipid metabolism (HP:0010969)1.69474072
159Abnormality of liposaccharide metabolism (HP:0010968)1.69474072
160Fat malabsorption (HP:0002630)1.69199825
161Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.68699676
162Elevated erythrocyte sedimentation rate (HP:0003565)1.68409349
163Hypoplastic left heart (HP:0004383)1.67666830
164Hepatocellular carcinoma (HP:0001402)1.67259351
165Subacute progressive viral hepatitis (HP:0006572)1.65786238
166Myoglobinuria (HP:0002913)1.65358345
167Patchy hypopigmentation of hair (HP:0011365)1.65172295
168Abnormality of dentin (HP:0010299)1.65036704
169Cortical dysplasia (HP:0002539)1.64743898
170Glycosuria (HP:0003076)1.64686753
171Abnormality of urine glucose concentration (HP:0011016)1.64686753
172Abnormality of nucleobase metabolism (HP:0010932)1.64671317
173Hypolipoproteinemia (HP:0010981)1.64181861
174Mucosal telangiectasiae (HP:0100579)1.63349175
175Ovoid vertebral bodies (HP:0003300)1.63023604
176Aortic dissection (HP:0002647)1.62039923
177Cardiomegaly (HP:0001640)1.61393142
178Abnormal cartilage morphology (HP:0002763)1.60239114
179Spontaneous hematomas (HP:0007420)1.59226567
180Abnormality of complement system (HP:0005339)1.58181557
181Abnormal gallbladder morphology (HP:0012437)1.57936656
182Elevated alkaline phosphatase (HP:0003155)1.57157373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.64006497
2TRIB34.60900105
3ERN14.28388854
4EIF2AK14.27012646
5PBK3.39686266
6STK163.16798010
7PASK3.06510653
8MST42.96209750
9SRPK12.84221034
10PKN22.80895324
11PRKD32.72601500
12FLT32.67639910
13TRIM282.60420842
14SCYL22.49044531
15TAOK32.45551349
16BUB12.43093303
17MYLK2.35652022
18ERBB32.29352195
19TESK12.29166693
20MAP4K22.07965346
21MAP3K121.92439994
22LRRK21.90716277
23PTK61.89228701
24MAP3K21.88688351
25ZAP701.88396361
26EEF2K1.77812185
27PDGFRA1.77107234
28NME21.75154475
29TBK11.74222451
30TTK1.72155540
31NME11.71940356
32PIM21.71673318
33MAP4K11.68421333
34FGFR41.68014407
35TSSK61.67461007
36RIPK11.59896953
37MAP3K101.59857323
38NEK91.54905533
39BCKDK1.54044127
40TYK21.50278938
41JAK31.48893301
42JAK11.46337940
43PLK41.45843765
44INSRR1.44272018
45SIK31.38634953
46PLK31.37983561
47SIK11.37530375
48ERBB41.35797833
49EPHB11.35619025
50TTN1.33849238
51ZAK1.30481106
52KIT1.29589831
53MST1R1.24714681
54VRK21.22185353
55TESK21.21414918
56KSR21.20189457
57PDK41.19361569
58PDK31.19361569
59RET1.18993827
60BMPR1B1.16103917
61PTK21.15785499
62STK101.14855406
63WEE11.12121533
64AKT31.11277128
65MAP2K31.10854759
66BCR1.10647914
67PRKCH1.09687254
68PLK21.09500435
69EPHA31.09397370
70JAK21.06642179
71NTRK11.05578081
72KDR1.05434777
73MET1.04692999
74IRAK30.98421757
75TGFBR20.97948542
76MAP3K30.96838179
77CSNK1G10.93006035
78BRSK20.92821784
79PLK10.92348334
80CSF1R0.92263585
81PAK30.90893862
82HIPK20.90230310
83TGFBR10.90097451
84MAP3K10.87348399
85CLK10.86463470
86CSNK1G30.85460073
87PAK40.83004132
88IRAK40.81989059
89LMTK20.80137098
90EIF2AK20.79045038
91RAF10.78023578
92ITK0.74929664
93CAMKK10.74309621
94PDGFRB0.73847107
95CAMKK20.73537527
96ACVR1B0.73508643
97TNIK0.72155714
98CSNK1A1L0.72014132
99FER0.70818081
100DAPK30.69625543
101DYRK1B0.69377391
102BRD40.68661555
103NUAK10.65006951
104DAPK10.64630283
105RPS6KA40.64326687
106CSK0.63603636
107LIMK10.63470487
108ATR0.62428746
109WNK40.62032827
110CCNB10.61585070
111AURKA0.60115854
112NLK0.58576005
113MAPK150.58531752
114CDK80.58428240
115ALK0.58378773
116BMPR20.57703783
117FRK0.57432236
118PAK20.57144893
119CAMK1D0.56132860
120CDC70.55995453
121AURKB0.55383466
122STK30.55071267
123VRK10.53686840
124CDK90.53376275
125PAK10.52942781
126SYK0.52655285
127IRAK10.51127283
128MTOR0.50586047
129STK40.48858212
130EPHA20.48153009
131PIK3CG0.47289336
132PDPK10.46860518
133MAP3K140.46696715
134PDK10.46584454
135PRKG20.46384375
136CHEK10.45325481
137CSNK1G20.45065765
138MAP2K20.44604586
139ATM0.44510060
140MAP3K80.44166364
141FGFR30.43595408
142GRK60.43545003
143MAPKAPK30.43421607
144BMX0.42564229
145TRPM70.41789603
146ABL20.41784276
147CDK70.41756530
148ILK0.41576202
149MAPK110.41186910
150AKT20.40855747
151DDR20.40671863
152CSNK2A10.39415837
153IGF1R0.38962259
154PRKCE0.38659767
155BRSK10.38216023
156IKBKE0.37844668
157MARK30.37789316
158TAOK10.37492499
159PDK20.36767733
160EGFR0.36580634
161LATS10.36119972
162MAP2K10.35062804
163MAP3K50.35018233
164CSNK2A20.34406834
165MAP2K70.34100770
166NEK10.33744603
167MUSK0.32832452
168ROCK10.32272251
169LCK0.32267148
170CHEK20.31887643
171FGFR10.31249825
172ICK0.30643631

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.66812761
2Proteasome_Homo sapiens_hsa030504.44264350
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.12598255
4Protein export_Homo sapiens_hsa030603.09454011
5Sulfur metabolism_Homo sapiens_hsa009202.83744166
6Fatty acid elongation_Homo sapiens_hsa000622.54103626
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40958144
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34063131
9Selenocompound metabolism_Homo sapiens_hsa004502.23293851
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20328278
11Lysosome_Homo sapiens_hsa041422.15488765
12Mismatch repair_Homo sapiens_hsa034302.08207523
13RNA polymerase_Homo sapiens_hsa030202.07571826
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07297774
15Nitrogen metabolism_Homo sapiens_hsa009102.01831172
16Non-homologous end-joining_Homo sapiens_hsa034501.95756589
17DNA replication_Homo sapiens_hsa030301.95672537
18Fatty acid degradation_Homo sapiens_hsa000711.74389712
19Glutathione metabolism_Homo sapiens_hsa004801.70009451
20Tryptophan metabolism_Homo sapiens_hsa003801.69482935
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68362935
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64015172
23N-Glycan biosynthesis_Homo sapiens_hsa005101.63268384
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.63156555
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.62911551
26RNA transport_Homo sapiens_hsa030131.45225087
27Antigen processing and presentation_Homo sapiens_hsa046121.44512068
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.42763136
29Pyrimidine metabolism_Homo sapiens_hsa002401.41796557
30Homologous recombination_Homo sapiens_hsa034401.41159188
31Fat digestion and absorption_Homo sapiens_hsa049751.38111385
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36974817
33Base excision repair_Homo sapiens_hsa034101.34925066
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33055453
35One carbon pool by folate_Homo sapiens_hsa006701.29047841
36Fatty acid metabolism_Homo sapiens_hsa012121.28972037
37Oxidative phosphorylation_Homo sapiens_hsa001901.28913967
38Legionellosis_Homo sapiens_hsa051341.28699801
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.28224331
40Sulfur relay system_Homo sapiens_hsa041221.26493311
41Insulin resistance_Homo sapiens_hsa049311.26127035
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24900108
43Type I diabetes mellitus_Homo sapiens_hsa049401.22077713
44Fanconi anemia pathway_Homo sapiens_hsa034601.21997059
45Butanoate metabolism_Homo sapiens_hsa006501.19171427
46Complement and coagulation cascades_Homo sapiens_hsa046101.18133842
47Spliceosome_Homo sapiens_hsa030401.17947216
48Nucleotide excision repair_Homo sapiens_hsa034201.17121396
49Staphylococcus aureus infection_Homo sapiens_hsa051501.16444823
50Type II diabetes mellitus_Homo sapiens_hsa049301.15924531
51Arginine biosynthesis_Homo sapiens_hsa002201.15364993
52Parkinsons disease_Homo sapiens_hsa050121.13089806
53Pyruvate metabolism_Homo sapiens_hsa006201.12360891
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12301217
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11558826
56Steroid biosynthesis_Homo sapiens_hsa001001.10084674
57Propanoate metabolism_Homo sapiens_hsa006401.09804996
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07803133
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07182329
60Vibrio cholerae infection_Homo sapiens_hsa051101.05317312
61Folate biosynthesis_Homo sapiens_hsa007901.05007876
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03664570
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02667900
64Prion diseases_Homo sapiens_hsa050201.01782646
65PPAR signaling pathway_Homo sapiens_hsa033200.98028549
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.96131448
67Arginine and proline metabolism_Homo sapiens_hsa003300.95301582
68Leishmaniasis_Homo sapiens_hsa051400.94563141
69Vitamin B6 metabolism_Homo sapiens_hsa007500.94126776
70Cell cycle_Homo sapiens_hsa041100.93214490
71Purine metabolism_Homo sapiens_hsa002300.91175763
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89588030
73Carbon metabolism_Homo sapiens_hsa012000.87652213
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.86306276
75Basal transcription factors_Homo sapiens_hsa030220.86279867
76Huntingtons disease_Homo sapiens_hsa050160.85488677
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85009823
78Caffeine metabolism_Homo sapiens_hsa002320.83846834
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81666963
80Galactose metabolism_Homo sapiens_hsa000520.81518374
81Starch and sucrose metabolism_Homo sapiens_hsa005000.81108291
82Peroxisome_Homo sapiens_hsa041460.80894363
83* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80013478
84ABC transporters_Homo sapiens_hsa020100.79677152
85Collecting duct acid secretion_Homo sapiens_hsa049660.79252509
86Metabolic pathways_Homo sapiens_hsa011000.78786369
87Pertussis_Homo sapiens_hsa051330.78456571
88RNA degradation_Homo sapiens_hsa030180.77825682
89Osteoclast differentiation_Homo sapiens_hsa043800.77602702
90Chronic myeloid leukemia_Homo sapiens_hsa052200.76246871
91Phagosome_Homo sapiens_hsa041450.76246793
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76205088
93p53 signaling pathway_Homo sapiens_hsa041150.74729721
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73974060
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71909738
96Prolactin signaling pathway_Homo sapiens_hsa049170.71058925
97Toxoplasmosis_Homo sapiens_hsa051450.70771499
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70313942
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.70210458
100Bile secretion_Homo sapiens_hsa049760.69837968
101Shigellosis_Homo sapiens_hsa051310.69660363
102Biosynthesis of amino acids_Homo sapiens_hsa012300.68556937
103Other glycan degradation_Homo sapiens_hsa005110.66566923
104Tuberculosis_Homo sapiens_hsa051520.63922197
105Sphingolipid metabolism_Homo sapiens_hsa006000.63185965
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61520296
107Pancreatic cancer_Homo sapiens_hsa052120.61456528
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.59896530
109Phenylalanine metabolism_Homo sapiens_hsa003600.58074907
110Glucagon signaling pathway_Homo sapiens_hsa049220.57626491
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56444135
112Insulin secretion_Homo sapiens_hsa049110.56295309
113Endocytosis_Homo sapiens_hsa041440.56113541
114Amoebiasis_Homo sapiens_hsa051460.56006391
115Thyroid hormone synthesis_Homo sapiens_hsa049180.55428454
116Fructose and mannose metabolism_Homo sapiens_hsa000510.55001154
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54853707
118mTOR signaling pathway_Homo sapiens_hsa041500.54778700
119mRNA surveillance pathway_Homo sapiens_hsa030150.53920067
120Insulin signaling pathway_Homo sapiens_hsa049100.52786919
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.52564436
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52208697
123Histidine metabolism_Homo sapiens_hsa003400.51989697
124Focal adhesion_Homo sapiens_hsa045100.51357579
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51311652
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50653397
127Regulation of autophagy_Homo sapiens_hsa041400.50444945
128Alzheimers disease_Homo sapiens_hsa050100.47890446
129Oocyte meiosis_Homo sapiens_hsa041140.47574889
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.46943764
131Proteoglycans in cancer_Homo sapiens_hsa052050.46885799
132Pentose phosphate pathway_Homo sapiens_hsa000300.46499314
133Apoptosis_Homo sapiens_hsa042100.46250883
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45929764
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45606730
136Renal cell carcinoma_Homo sapiens_hsa052110.45078540
137Lysine degradation_Homo sapiens_hsa003100.44653988
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44269444
139Viral carcinogenesis_Homo sapiens_hsa052030.43814361
140Vitamin digestion and absorption_Homo sapiens_hsa049770.42758722
141B cell receptor signaling pathway_Homo sapiens_hsa046620.41360481
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40167044
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40076885
144TNF signaling pathway_Homo sapiens_hsa046680.40005545
145Viral myocarditis_Homo sapiens_hsa054160.39793844
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39645160
147beta-Alanine metabolism_Homo sapiens_hsa004100.39496145
148VEGF signaling pathway_Homo sapiens_hsa043700.39431716
149Renin-angiotensin system_Homo sapiens_hsa046140.39419933
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38733457
151TGF-beta signaling pathway_Homo sapiens_hsa043500.38019025
152Retinol metabolism_Homo sapiens_hsa008300.35289296
153Mineral absorption_Homo sapiens_hsa049780.32288044
154Chemical carcinogenesis_Homo sapiens_hsa052040.29844715

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