GOT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)5.74921009
2muscle filament sliding (GO:0030049)5.74921009
3tricarboxylic acid cycle (GO:0006099)5.11015235
4NADH metabolic process (GO:0006734)4.85081363
5creatine metabolic process (GO:0006600)4.62846358
6actin-mediated cell contraction (GO:0070252)4.61770051
7regulation of actin filament-based movement (GO:1903115)4.49872311
8regulation of relaxation of muscle (GO:1901077)4.49605306
9striated muscle contraction (GO:0006941)4.45116143
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.16549733
11succinate metabolic process (GO:0006105)4.12036888
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.05449870
13glutamate secretion (GO:0014047)4.03723664
14synaptic vesicle exocytosis (GO:0016079)4.02486340
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.92205437
16sodium ion export (GO:0071436)3.89456857
17regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.85730459
18regulation of acyl-CoA biosynthetic process (GO:0050812)3.82358276
19response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.81355138
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.77621343
21positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.71551117
22regulation of coenzyme metabolic process (GO:0051196)3.68696409
23regulation of cofactor metabolic process (GO:0051193)3.68696409
24vocalization behavior (GO:0071625)3.63925687
25skeletal muscle contraction (GO:0003009)3.63045645
26neurotransmitter-gated ion channel clustering (GO:0072578)3.59695384
27regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.57827604
28lysine metabolic process (GO:0006553)3.55185431
29lysine catabolic process (GO:0006554)3.55185431
30neurotransmitter secretion (GO:0007269)3.51219200
31synaptic vesicle maturation (GO:0016188)3.48974757
32regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.48012130
33regulation of synaptic vesicle exocytosis (GO:2000300)3.46475143
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.45597538
35neuronal action potential propagation (GO:0019227)3.45055897
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.44062453
37* oxaloacetate metabolic process (GO:0006107)3.43978661
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40570294
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38385009
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.36658755
41regulation of the force of heart contraction (GO:0002026)3.33849591
42gamma-aminobutyric acid transport (GO:0015812)3.32275571
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.30504329
44regulation of glutamate receptor signaling pathway (GO:1900449)3.29848088
45actin filament-based movement (GO:0030048)3.28944855
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.26943940
47glyoxylate metabolic process (GO:0046487)3.26904514
48cellular ketone body metabolic process (GO:0046950)3.26098989
49cell communication by electrical coupling (GO:0010644)3.25354778
50regulation of synaptic vesicle transport (GO:1902803)3.21070511
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.19489656
52neuromuscular process controlling posture (GO:0050884)3.18666144
53actomyosin structure organization (GO:0031032)3.18350145
54cardiac muscle contraction (GO:0060048)3.18267453
55cardiac myofibril assembly (GO:0055003)3.14467575
56response to muscle activity (GO:0014850)3.14455828
57regulation of cardiac muscle cell contraction (GO:0086004)3.14063590
58cell communication involved in cardiac conduction (GO:0086065)3.10411110
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10315519
60positive regulation of synapse maturation (GO:0090129)3.10205558
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.08697595
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07796631
63ventricular cardiac muscle cell action potential (GO:0086005)3.07486729
64muscle hypertrophy (GO:0014896)3.07020717
65regulation of skeletal muscle contraction (GO:0014819)3.03082333
66negative regulation of potassium ion transmembrane transport (GO:1901380)3.01934937
67L-phenylalanine catabolic process (GO:0006559)3.01052677
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.01052677
69locomotory exploration behavior (GO:0035641)3.00913074
70cellular sodium ion homeostasis (GO:0006883)2.98408337
71sarcomere organization (GO:0045214)2.97509635
72regulation of cell communication by electrical coupling (GO:0010649)2.97434001
73regulation of synapse structural plasticity (GO:0051823)2.97252538
74positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.97224678
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.96673230
76L-phenylalanine metabolic process (GO:0006558)2.96673230
77ATP hydrolysis coupled proton transport (GO:0015991)2.96287097
78energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.96287097
79muscle contraction (GO:0006936)2.96246567
80regulation of membrane repolarization (GO:0060306)2.96092194
81* aspartate family amino acid catabolic process (GO:0009068)2.95087635
82regulation of striated muscle contraction (GO:0006942)2.93643240
83cardiac muscle hypertrophy in response to stress (GO:0014898)2.93474829
84muscle hypertrophy in response to stress (GO:0003299)2.93474829
85cardiac muscle adaptation (GO:0014887)2.93474829
86* gluconeogenesis (GO:0006094)2.93454454
87respiratory electron transport chain (GO:0022904)2.92747835
88oxidative phosphorylation (GO:0006119)2.91952053
89regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.90260920
90* monosaccharide biosynthetic process (GO:0046364)2.89207766
91regulation of sodium ion transmembrane transporter activity (GO:2000649)2.88756305
92ketone body metabolic process (GO:1902224)2.88527512
93regulation of sulfur metabolic process (GO:0042762)2.87639922
94adult heart development (GO:0007512)2.87399757
95protein localization to synapse (GO:0035418)2.85737005
96behavioral response to cocaine (GO:0048148)2.85184624
97activation of protein kinase A activity (GO:0034199)2.84170286
98electron transport chain (GO:0022900)2.84005819
99cardiac conduction (GO:0061337)2.83473946
100neuron-neuron synaptic transmission (GO:0007270)2.81972850
101negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.81479993
102negative regulation of calcium ion transmembrane transport (GO:1903170)2.81479993
103cardiac muscle hypertrophy (GO:0003300)2.81362094
104kynurenine metabolic process (GO:0070189)2.79845389
105* 2-oxoglutarate metabolic process (GO:0006103)2.79522164
106ATP synthesis coupled proton transport (GO:0015986)2.78657474
107energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78657474
108cardiac muscle cell development (GO:0055013)2.78551081
109carnitine shuttle (GO:0006853)2.77646354
110potassium ion homeostasis (GO:0055075)2.77301436
111detection of calcium ion (GO:0005513)2.76588389
112cardiac muscle tissue morphogenesis (GO:0055008)2.76377871
113striatum development (GO:0021756)2.75249821
114neurotransmitter transport (GO:0006836)2.75167277
115heart process (GO:0003015)2.74998067
116heart contraction (GO:0060047)2.74998067
117response to mercury ion (GO:0046689)2.74857380
118cardiac muscle cell action potential involved in contraction (GO:0086002)2.74302625
119cardiac muscle cell action potential (GO:0086001)2.74002384
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.73464802
121* hexose biosynthetic process (GO:0019319)2.73444008
122glycogen catabolic process (GO:0005980)2.71858478
123sarcoplasmic reticulum calcium ion transport (GO:0070296)2.69504397
124regulation of heart rate (GO:0002027)2.68551235
125striated muscle hypertrophy (GO:0014897)2.68516674
126regulation of heart rate by cardiac conduction (GO:0086091)2.68158279
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67761958
128NAD metabolic process (GO:0019674)2.67239429
129fatty acid transmembrane transport (GO:1902001)2.66163856
130* dicarboxylic acid catabolic process (GO:0043649)2.65837664
131fructose metabolic process (GO:0006000)2.65676599
132relaxation of cardiac muscle (GO:0055119)2.64597179
133muscle system process (GO:0003012)2.64487394
134myofibril assembly (GO:0030239)2.64452768
135* glutamate metabolic process (GO:0006536)2.64236029
136membrane depolarization during action potential (GO:0086010)2.64171870
137positive regulation of sodium ion transport (GO:0010765)2.63689417
138regulation of neurotransmitter levels (GO:0001505)2.63574997
139regulation of voltage-gated calcium channel activity (GO:1901385)2.63489156
140regulation of sodium ion transmembrane transport (GO:1902305)2.63212228
141glycolytic process (GO:0006096)2.62699459
142regulation of calcium ion transmembrane transporter activity (GO:1901019)2.61807655
143regulation of calcium ion transmembrane transport (GO:1903169)2.61807655
144cellular potassium ion homeostasis (GO:0030007)2.61651461
145epoxygenase P450 pathway (GO:0019373)2.59405167
146muscle tissue morphogenesis (GO:0060415)2.58624593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.45987741
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.92700722
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.72729207
4GBX2_23144817_ChIP-Seq_PC3_Human3.34866377
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.17671998
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.57012652
7* RXR_22158963_ChIP-Seq_LIVER_Mouse2.52667476
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.52485064
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.47905022
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43217851
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.41525223
12REST_21632747_ChIP-Seq_MESCs_Mouse2.41417656
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.35207631
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24996389
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20106262
16DROSHA_22980978_ChIP-Seq_HELA_Human2.10329000
17TAF15_26573619_Chip-Seq_HEK293_Human2.09937565
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.08678170
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.02984205
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02690069
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94189406
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92682293
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91282279
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87571327
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87571327
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80281106
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79730995
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76809615
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76270756
30* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70876032
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64120745
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63484923
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63378904
34* TBX20_22080862_ChIP-Seq_HEART_Mouse1.61553860
35* TBX20_22328084_ChIP-Seq_HEART_Mouse1.61553860
36SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.57801920
37CLOCK_20551151_ChIP-Seq_293T_Human1.57380587
38MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.55430901
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.54714121
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.54666710
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53423394
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53152847
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51346278
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.51316939
45SMAD4_21799915_ChIP-Seq_A2780_Human1.51175124
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.50230945
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.49857186
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47686407
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46165432
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43723936
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40283569
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40217806
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.37212572
54* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34039440
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.33753507
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31858880
57AR_21572438_ChIP-Seq_LNCaP_Human1.30990424
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28886954
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27642896
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27257203
61GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.24864555
62* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23890701
63* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.23356433
64* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23337602
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23012141
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22321268
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22140568
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21885057
69AR_21909140_ChIP-Seq_LNCAP_Human1.21077426
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.20781017
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20271834
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18688439
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.18387202
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15887676
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14155867
76HTT_18923047_ChIP-ChIP_STHdh_Human1.12165373
77VDR_22108803_ChIP-Seq_LS180_Human1.10634758
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10091462
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09969550
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08808424
81P300_19829295_ChIP-Seq_ESCs_Human1.07563866
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07102298
83AR_25329375_ChIP-Seq_VCAP_Human1.06788184
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05827995
85* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05772926
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.04826042
87AR_19668381_ChIP-Seq_PC3_Human1.04503053
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03969648
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03803879
90NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02514972
91STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02492521
92TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01386645
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.01277369
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00408547
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00207093
96PIAS1_25552417_ChIP-Seq_VCAP_Human0.99027995
97ZNF274_21170338_ChIP-Seq_K562_Hela0.98480772
98TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98312497
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97155441
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96788914
101CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96112582
102ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95665330
103* SMAD3_21741376_ChIP-Seq_EPCs_Human0.95476974
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94513443
105ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94124992
106STAT3_23295773_ChIP-Seq_U87_Human0.93821513
107* TET1_21451524_ChIP-Seq_MESCs_Mouse0.93733733
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93692707
109LXR_22292898_ChIP-Seq_THP-1_Human0.92797589
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92438888
111TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92256161
112* CTCF_27219007_Chip-Seq_Bcells_Human0.92184924
113* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91999442
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91868753
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91516522
116ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91217886
117* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90989891
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90942672
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90425424
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89600860
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88943652
122* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88321430
123BCAT_22108803_ChIP-Seq_LS180_Human0.88154729
124IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88148293
125* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87602852
126TCF4_23295773_ChIP-Seq_U87_Human0.87502231
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87494054
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.85949133
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83710336
130ZNF263_19887448_ChIP-Seq_K562_Human0.83557887
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83169378
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82874919
133* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82305831
134* SMAD3_21741376_ChIP-Seq_HESCs_Human0.82224735
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82138721
136* FOXA2_19822575_ChIP-Seq_HepG2_Human0.82093944
137SMC4_20622854_ChIP-Seq_HELA_Human0.81770803
138P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81702730
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79278811
140MYC_18555785_ChIP-Seq_MESCs_Mouse0.79119016
141AHR_22903824_ChIP-Seq_MCF-7_Human0.77983080
142YY1_21170310_ChIP-Seq_MESCs_Mouse0.77966884
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.77791144
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77488380
145* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76394896
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74317492
147KLF4_19829295_ChIP-Seq_ESCs_Human0.74276558
148* SMAD4_21741376_ChIP-Seq_EPCs_Human0.74274795
149RING1B_27294783_Chip-Seq_ESCs_Mouse0.73088704
150OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72999084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.28163888
2MP0004859_abnormal_synaptic_plasticity3.96595105
3MP0003646_muscle_fatigue3.65325888
4MP0003880_abnormal_central_pattern3.43908405
5MP0000751_myopathy3.21423525
6MP0003635_abnormal_synaptic_transmissio2.75517568
7MP0002822_catalepsy2.74903654
8MP0004215_abnormal_myocardial_fiber2.67454995
9MP0004084_abnormal_cardiac_muscle2.66864061
10MP0009046_muscle_twitch2.65833806
11MP0002139_abnormal_hepatobiliary_system2.50549397
12MP0005085_abnormal_gallbladder_physiolo2.49363489
13MP0009745_abnormal_behavioral_response2.48341816
14MP0005360_urolithiasis2.45923707
15MP0002064_seizures2.44028897
16MP0004036_abnormal_muscle_relaxation2.42608012
17MP0002063_abnormal_learning/memory/cond2.18981145
18MP0004270_analgesia2.18310593
19MP0008875_abnormal_xenobiotic_pharmacok2.08289252
20MP0000749_muscle_degeneration2.01714074
21MP0001968_abnormal_touch/_nociception2.01494500
22MP0002272_abnormal_nervous_system1.94446784
23MP0005365_abnormal_bile_salt1.94066014
24MP0002572_abnormal_emotion/affect_behav1.87955473
25MP0005330_cardiomyopathy1.84811400
26MP0004130_abnormal_muscle_cell1.83593888
27MP0002736_abnormal_nociception_after1.77728018
28MP0006036_abnormal_mitochondrial_physio1.69952920
29MP0003806_abnormal_nucleotide_metabolis1.69898565
30MP0005451_abnormal_body_composition1.68208825
31MP0003137_abnormal_impulse_conducting1.61711663
32MP0001440_abnormal_grooming_behavior1.56924201
33MP0004145_abnormal_muscle_electrophysio1.56471026
34MP0001501_abnormal_sleep_pattern1.55935449
35MP0004484_altered_response_of1.55385624
36MP0001486_abnormal_startle_reflex1.53591792
37MP0004085_abnormal_heartbeat1.53260384
38MP0002972_abnormal_cardiac_muscle1.53154326
39MP0006035_abnormal_mitochondrial_morpho1.52829487
40MP0005620_abnormal_muscle_contractility1.52387733
41MP0005670_abnormal_white_adipose1.49077448
42MP0002269_muscular_atrophy1.48867034
43MP0002734_abnormal_mechanical_nocicepti1.47650858
44MP0003195_calcinosis1.46079505
45MP0003329_amyloid_beta_deposits1.45980041
46MP0009780_abnormal_chondrocyte_physiolo1.42351234
47MP0004233_abnormal_muscle_weight1.42094990
48MP0010329_abnormal_lipoprotein_level1.41532862
49MP0002067_abnormal_sensory_capabilities1.40319906
50MP0004087_abnormal_muscle_fiber1.39787420
51MP0002909_abnormal_adrenal_gland1.39374596
52MP0004924_abnormal_behavior1.38869515
53MP0005386_behavior/neurological_phenoty1.38869515
54MP0002735_abnormal_chemical_nociception1.38644167
55MP0008775_abnormal_heart_ventricle1.36506653
56MP0002332_abnormal_exercise_endurance1.36157453
57MP0005332_abnormal_amino_acid1.34605503
58MP0003123_paternal_imprinting1.32013377
59MP0003879_abnormal_hair_cell1.29501648
60MP0004147_increased_porphyrin_level1.29374884
61MP0000747_muscle_weakness1.29116150
62MP0005646_abnormal_pituitary_gland1.26228656
63MP0004142_abnormal_muscle_tone1.24647078
64MP0006138_congestive_heart_failure1.23173344
65MP0001984_abnormal_olfaction1.20636734
66MP0008569_lethality_at_weaning1.17159426
67MP0002106_abnormal_muscle_physiology1.16821017
68MP0005385_cardiovascular_system_phenoty1.15616639
69MP0001544_abnormal_cardiovascular_syste1.15616639
70MP0001529_abnormal_vocalization1.14035162
71MP0005423_abnormal_somatic_nervous1.10474050
72MP0001970_abnormal_pain_threshold1.09778067
73MP0004043_abnormal_pH_regulation1.09649820
74MP0005535_abnormal_body_temperature1.08462616
75MP0003252_abnormal_bile_duct1.07259446
76MP0009840_abnormal_foam_cell1.06834257
77MP0006276_abnormal_autonomic_nervous1.05988670
78MP0002733_abnormal_thermal_nociception1.04237812
79MP0005083_abnormal_biliary_tract1.04139665
80MP0008874_decreased_physiological_sensi1.01088062
81MP0002066_abnormal_motor_capabilities/c0.99333608
82MP0003633_abnormal_nervous_system0.98944915
83MP0005584_abnormal_enzyme/coenzyme_acti0.97280432
84MP0005369_muscle_phenotype0.96700187
85MP0004510_myositis0.96600169
86MP0005266_abnormal_metabolism0.96056493
87MP0008872_abnormal_physiological_respon0.96006106
88MP0005551_abnormal_eye_electrophysiolog0.95731579
89MP0000759_abnormal_skeletal_muscle0.95386909
90MP0004811_abnormal_neuron_physiology0.93781578
91MP0002876_abnormal_thyroid_physiology0.93091451
92MP0009697_abnormal_copulation0.91647221
93MP0002118_abnormal_lipid_homeostasis0.91476294
94MP0000013_abnormal_adipose_tissue0.89779903
95MP0001661_extended_life_span0.89336690
96MP0000604_amyloidosis0.88151815
97MP0005165_increased_susceptibility_to0.87828591
98MP0002557_abnormal_social/conspecific_i0.86844512
99MP0000750_abnormal_muscle_regeneration0.85063081
100MP0002229_neurodegeneration0.81228271
101MP0005187_abnormal_penis_morphology0.80493203
102MP0003868_abnormal_feces_composition0.80466368
103MP0003221_abnormal_cardiomyocyte_apopto0.80305384
104MP0003631_nervous_system_phenotype0.79389278
105MP0005319_abnormal_enzyme/_coenzyme0.78703892
106MP0002090_abnormal_vision0.77479734
107MP0010630_abnormal_cardiac_muscle0.77165566
108MP0002184_abnormal_innervation0.77145750
109MP0000230_abnormal_systemic_arterial0.76448063
110MP0002127_abnormal_cardiovascular_syste0.75443163
111MP0001346_abnormal_lacrimal_gland0.73680531
112MP0001666_abnormal_nutrient_absorption0.69136728
113MP0000003_abnormal_adipose_tissue0.68929047
114MP0002234_abnormal_pharynx_morphology0.66174268
115MP0002971_abnormal_brown_adipose0.66096667
116MP0000920_abnormal_myelination0.64428800
117MP0001502_abnormal_circadian_rhythm0.63037477
118MP0001299_abnormal_eye_distance/0.58807574
119MP0009672_abnormal_birth_weight0.56317030

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.10017453
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.94398242
3Nemaline bodies (HP:0003798)5.92290305
4Focal motor seizures (HP:0011153)5.38350052
5Type 1 muscle fiber predominance (HP:0003803)4.48494454
6Sudden death (HP:0001699)4.16501728
7Exercise-induced myalgia (HP:0003738)4.06594270
8Myokymia (HP:0002411)3.95264680
9Exercise-induced muscle cramps (HP:0003710)3.68760349
10Atonic seizures (HP:0010819)3.60948512
11Focal seizures (HP:0007359)3.46716655
12Abnormality of the left ventricular outflow tract (HP:0011103)3.39995307
13Subaortic stenosis (HP:0001682)3.39995307
14Abnormal mitochondria in muscle tissue (HP:0008316)3.39092974
15Centrally nucleated skeletal muscle fibers (HP:0003687)3.36061358
16Pheochromocytoma (HP:0002666)3.34291787
17Distal lower limb muscle weakness (HP:0009053)3.33085731
18Calf muscle hypertrophy (HP:0008981)3.28091278
19Myoglobinuria (HP:0002913)3.26437403
20Myopathic facies (HP:0002058)3.24508723
21Acute necrotizing encephalopathy (HP:0006965)3.21187565
22Absence seizures (HP:0002121)3.18767034
23Epileptic encephalopathy (HP:0200134)3.18317352
24Febrile seizures (HP:0002373)3.16449864
25Muscle hypertrophy of the lower extremities (HP:0008968)3.11236679
26Hyperventilation (HP:0002883)3.11178356
27Rimmed vacuoles (HP:0003805)3.08676859
28Neck muscle weakness (HP:0000467)3.07518494
29Acute encephalopathy (HP:0006846)3.07380850
30Dysmetric saccades (HP:0000641)3.06995885
31Cerebral edema (HP:0002181)3.06670257
32Neuroendocrine neoplasm (HP:0100634)3.06408982
33Visual hallucinations (HP:0002367)3.04786211
34Syncope (HP:0001279)2.99147287
35EMG: neuropathic changes (HP:0003445)2.95972938
36Atrial fibrillation (HP:0005110)2.92109044
37Dilated cardiomyopathy (HP:0001644)2.90531080
38Generalized tonic-clonic seizures (HP:0002069)2.90175380
39Bundle branch block (HP:0011710)2.90143432
40Palpitations (HP:0001962)2.86492893
41Dialeptic seizures (HP:0011146)2.85040370
42Abnormality of glycolysis (HP:0004366)2.82849100
43Increased serum pyruvate (HP:0003542)2.82849100
44Abnormality of the calf musculature (HP:0001430)2.79222305
45Hepatocellular necrosis (HP:0001404)2.76493530
46Primary atrial arrhythmia (HP:0001692)2.76084413
47Progressive macrocephaly (HP:0004481)2.76062199
48Asymmetric septal hypertrophy (HP:0001670)2.71970499
49Ventricular fibrillation (HP:0001663)2.71856044
50Hepatic necrosis (HP:0002605)2.70633259
51Cholecystitis (HP:0001082)2.70504202
52Abnormal gallbladder physiology (HP:0012438)2.70504202
53Ketoacidosis (HP:0001993)2.66899921
54Ketosis (HP:0001946)2.66768012
55Ventricular tachycardia (HP:0004756)2.64442340
56Supraventricular tachycardia (HP:0004755)2.64361968
57Distal arthrogryposis (HP:0005684)2.63688489
58Increased connective tissue (HP:0009025)2.62950429
59Hyperammonemia (HP:0001987)2.60618232
60Mitochondrial inheritance (HP:0001427)2.60227008
61Muscle stiffness (HP:0003552)2.59444095
62Cholelithiasis (HP:0001081)2.59375092
63Increased CSF lactate (HP:0002490)2.56687186
64Supraventricular arrhythmia (HP:0005115)2.55361208
65Status epilepticus (HP:0002133)2.53387746
66Ragged-red muscle fibers (HP:0003200)2.48214576
67Abnormality of the foot musculature (HP:0001436)2.45316353
68Impaired social interactions (HP:0000735)2.45118514
69Abnormal social behavior (HP:0012433)2.45118514
70Prolonged partial thromboplastin time (HP:0003645)2.44814045
71Heart block (HP:0012722)2.42188068
72Gout (HP:0001997)2.41489863
73Dysdiadochokinesis (HP:0002075)2.41214564
74Myotonia (HP:0002486)2.40022818
75Abnormality of skeletal muscle fiber size (HP:0012084)2.39546556
76Abnormal gallbladder morphology (HP:0012437)2.38960357
77Poor eye contact (HP:0000817)2.37921475
78Ventricular arrhythmia (HP:0004308)2.36756058
79Abnormality of the lower motor neuron (HP:0002366)2.36244810
80Areflexia of lower limbs (HP:0002522)2.35556495
81Lactic acidosis (HP:0003128)2.35447228
82Difficulty running (HP:0009046)2.33963418
83Prolonged QT interval (HP:0001657)2.33922833
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.33273592
85EMG: myopathic abnormalities (HP:0003458)2.31893502
86Impaired vibration sensation in the lower limbs (HP:0002166)2.31628952
87Deep venous thrombosis (HP:0002625)2.31401016
88Increased intramyocellular lipid droplets (HP:0012240)2.30215564
89Atrioventricular block (HP:0001678)2.29424728
90Foot dorsiflexor weakness (HP:0009027)2.29416747
91Hyporeflexia of lower limbs (HP:0002600)2.25879068
92Rhabdomyolysis (HP:0003201)2.24569297
93Hypobetalipoproteinemia (HP:0003563)2.24262939
94Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23823578
95Progressive cerebellar ataxia (HP:0002073)2.23273816
96Round ear (HP:0100830)2.22222964
97Progressive muscle weakness (HP:0003323)2.21154935
98Distal lower limb amyotrophy (HP:0008944)2.21094735
99Exercise intolerance (HP:0003546)2.20817043
100Abnormal atrioventricular conduction (HP:0005150)2.20299040
101Right ventricular cardiomyopathy (HP:0011663)2.20134850
102Anxiety (HP:0000739)2.19898266
103Muscle fiber splitting (HP:0003555)2.18093336
104Resting tremor (HP:0002322)2.17041999
105Lethargy (HP:0001254)2.16179320
106Lower limb amyotrophy (HP:0007210)2.16136875
107Hyperglycinemia (HP:0002154)2.15544993
108Xanthomatosis (HP:0000991)2.14229406
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14155400
110Abnormality of alanine metabolism (HP:0010916)2.14155400
111Hyperalaninemia (HP:0003348)2.14155400
112Hyperlipoproteinemia (HP:0010980)2.12990967
113Frequent falls (HP:0002359)2.11692677
114Central scotoma (HP:0000603)2.11522559
115Oligomenorrhea (HP:0000876)2.10550648
116Increased variability in muscle fiber diameter (HP:0003557)2.09911965
117Abnormality of fatty-acid metabolism (HP:0004359)2.09252024
118Intrahepatic cholestasis (HP:0001406)2.08566109
119Athetosis (HP:0002305)2.07657731
120Hyperglycinuria (HP:0003108)2.07500513
121Left ventricular hypertrophy (HP:0001712)2.07484596
122Hypoalphalipoproteinemia (HP:0003233)2.06054618
123Depression (HP:0000716)2.06004658
124Mildly elevated creatine phosphokinase (HP:0008180)2.05044645
125Increased muscle lipid content (HP:0009058)2.02565626
126Metabolic acidosis (HP:0001942)2.02174717
127Abnormal EKG (HP:0003115)2.01312289
128Hypolipoproteinemia (HP:0010981)2.00994423
129Abnormality of glycine metabolism (HP:0010895)1.99103139
130Abnormality of serine family amino acid metabolism (HP:0010894)1.99103139
131Broad-based gait (HP:0002136)1.95583408
132Cerebral hypomyelination (HP:0006808)1.95036096
133Lipoatrophy (HP:0100578)1.94361246
134Postural instability (HP:0002172)1.93811636
135Respiratory failure (HP:0002878)1.92890203
136Complement deficiency (HP:0004431)1.92725372
137Generalized muscle weakness (HP:0003324)1.89715857
138Calcaneovalgus deformity (HP:0001848)1.85509974
139Ankle clonus (HP:0011448)1.83394610
140Ulnar deviation of the wrist (HP:0003049)1.76623028
141Tetraplegia (HP:0002445)1.74434816
142Difficulty climbing stairs (HP:0003551)1.74124496
143Limb-girdle muscle atrophy (HP:0003797)1.72214231
144Action tremor (HP:0002345)1.70885280
145Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70606789
146Fetal akinesia sequence (HP:0001989)1.68008086

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.40332634
2NTRK33.12540171
3MAP3K43.10293985
4PDK32.99210735
5PDK42.99210735
6NEK12.91877609
7MAP2K42.63090182
8MAP3K122.56930641
9MAP3K92.47881903
10MAP2K72.39150323
11DAPK22.36226821
12CASK2.33919058
13PHKG12.27263557
14PHKG22.27263557
15PINK11.96834460
16TTN1.90902877
17MINK11.89911650
18OBSCN1.87056039
19BCKDK1.85778622
20LMTK21.85327782
21PDK21.84638240
22DAPK11.75940378
23MYLK1.65246326
24LIMK11.62088529
25CDK191.51254168
26STK381.47960539
27PAK61.47160181
28PLK21.46926365
29KSR21.40502131
30AKT31.32995935
31CAMKK11.29755141
32ARAF1.27347699
33GRK51.23054946
34TSSK61.22886413
35NME11.21678465
36CCNB11.18888279
37PRKCG1.15118700
38CAMK2A1.12650695
39PRPF4B1.09142821
40EIF2AK11.08940283
41PKN21.06508334
42MARK11.05118952
43PBK1.04505382
44SGK21.04501981
45SGK2231.01102514
46SGK4941.01102514
47NTRK21.00544259
48BRSK10.99872757
49AKT20.95507143
50RIPK10.95447395
51SGK30.95273006
52CDK50.95062147
53BUB10.94632201
54CAMK2D0.94270063
55OXSR10.92656208
56PAK30.92336491
57KSR10.92214239
58DAPK30.91061588
59EEF2K0.87541207
60SCYL20.86442521
61CAMK2G0.86342717
62PRKD30.86281295
63GRK70.83091750
64MAPKAPK30.82521304
65MAP3K70.82286160
66MAPK120.81756303
67RIPK40.80721059
68CAMKK20.78577562
69TESK10.78006615
70PTK2B0.76660858
71CDK11A0.75478271
72LATS20.74614984
73CAMK2B0.74545257
74PDPK10.74203934
75PDK10.73538911
76CAMK10.71435060
77ICK0.71248947
78CAMK40.70700562
79MST1R0.70109534
80NTRK10.69103705
81ERBB40.64561240
82MUSK0.63609909
83TTK0.63414667
84PRKCH0.61408075
85PNCK0.61126822
86RAF10.59140354
87SGK10.56764207
88ROCK20.56369788
89PRKCE0.55793959
90TRIB30.55343537
91TAOK10.55110336
92DMPK0.54573227
93ALK0.54396581
94STK110.53891345
95MAP3K50.53733229
96FER0.53519536
97MAP3K130.52752181
98CDK180.52641533
99RET0.52526726
100CDC42BPA0.51662423
101MAPK100.50555183
102PKN10.50417938
103PIK3CA0.49980342
104BRAF0.49684080
105PIK3CG0.49401044
106CDK150.49182557
107PRKAA20.48381808
108STK38L0.48217542
109RPS6KA30.47784944
110MAP3K10.47715835
111PRKAA10.47333351
112PRKACA0.46399726
113CDK140.45631674
114PRKACG0.45541602
115FES0.43958202
116INSRR0.43250187
117MAP2K10.42177942
118MAPK70.41407488
119MAP2K60.40716507
120CSNK1E0.40469961
121TRPM70.40059955
122MAPK130.37659790
123PRKACB0.37566286
124UHMK10.37518999
125ROCK10.36848613
126PRKG10.36787940
127PRKD10.36650848
128ERBB30.36572830
129STK160.35380049
130MAPKAPK50.35303721
131DYRK1A0.35262557

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.96901756
2* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.97850071
3* Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97798910
4Synaptic vesicle cycle_Homo sapiens_hsa047212.59568642
5Nicotine addiction_Homo sapiens_hsa050332.31667063
6Nitrogen metabolism_Homo sapiens_hsa009102.31161654
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30276591
8Oxidative phosphorylation_Homo sapiens_hsa001902.13676160
9Pyruvate metabolism_Homo sapiens_hsa006202.07964224
10Propanoate metabolism_Homo sapiens_hsa006402.07154389
11* Arginine biosynthesis_Homo sapiens_hsa002202.00707974
12Cardiac muscle contraction_Homo sapiens_hsa042601.96646779
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.89934241
14* Carbon metabolism_Homo sapiens_hsa012001.88290397
15Collecting duct acid secretion_Homo sapiens_hsa049661.87062001
16Butanoate metabolism_Homo sapiens_hsa006501.85436641
17Parkinsons disease_Homo sapiens_hsa050121.76855878
18GABAergic synapse_Homo sapiens_hsa047271.76546339
19Fatty acid degradation_Homo sapiens_hsa000711.74338089
20* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69995175
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61387225
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59980756
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59957327
24Olfactory transduction_Homo sapiens_hsa047401.57884420
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55679966
26* Biosynthesis of amino acids_Homo sapiens_hsa012301.48289135
27Fatty acid metabolism_Homo sapiens_hsa012121.44298225
28Circadian entrainment_Homo sapiens_hsa047131.44038089
29Morphine addiction_Homo sapiens_hsa050321.37651439
30Alzheimers disease_Homo sapiens_hsa050101.37212942
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34105300
32Long-term potentiation_Homo sapiens_hsa047201.27870863
33Amphetamine addiction_Homo sapiens_hsa050311.23898511
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22456210
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21931540
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19088674
37Tryptophan metabolism_Homo sapiens_hsa003801.18507438
38Dilated cardiomyopathy_Homo sapiens_hsa054141.18072098
39Glutamatergic synapse_Homo sapiens_hsa047241.16329643
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15302630
41Insulin secretion_Homo sapiens_hsa049111.12482991
42Pentose phosphate pathway_Homo sapiens_hsa000301.12145301
43Bile secretion_Homo sapiens_hsa049761.07792911
44* Cysteine and methionine metabolism_Homo sapiens_hsa002701.05595016
45Dopaminergic synapse_Homo sapiens_hsa047281.03624480
46Salivary secretion_Homo sapiens_hsa049701.03477730
47Huntingtons disease_Homo sapiens_hsa050160.99689044
48Calcium signaling pathway_Homo sapiens_hsa040200.98185932
49Taste transduction_Homo sapiens_hsa047420.96365428
50beta-Alanine metabolism_Homo sapiens_hsa004100.95204870
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93946919
52PPAR signaling pathway_Homo sapiens_hsa033200.93389870
53Histidine metabolism_Homo sapiens_hsa003400.92904968
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91206205
55Gastric acid secretion_Homo sapiens_hsa049710.90665092
56Peroxisome_Homo sapiens_hsa041460.90147063
57Caffeine metabolism_Homo sapiens_hsa002320.87634100
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87584023
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87091483
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86716352
61Fatty acid elongation_Homo sapiens_hsa000620.86324357
62Vibrio cholerae infection_Homo sapiens_hsa051100.85926620
63Renin secretion_Homo sapiens_hsa049240.85743352
64Oxytocin signaling pathway_Homo sapiens_hsa049210.85254354
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84421708
66Glucagon signaling pathway_Homo sapiens_hsa049220.84399708
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82697237
68Prion diseases_Homo sapiens_hsa050200.81572669
69Fructose and mannose metabolism_Homo sapiens_hsa000510.79447854
70Retinol metabolism_Homo sapiens_hsa008300.78366344
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75919598
72Cholinergic synapse_Homo sapiens_hsa047250.74421850
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73746242
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72736681
75Starch and sucrose metabolism_Homo sapiens_hsa005000.71466667
76Sulfur relay system_Homo sapiens_hsa041220.66143922
77Oocyte meiosis_Homo sapiens_hsa041140.65588865
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.63157396
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60654761
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.60591716
81Complement and coagulation cascades_Homo sapiens_hsa046100.60030800
82Phototransduction_Homo sapiens_hsa047440.59645124
83Type II diabetes mellitus_Homo sapiens_hsa049300.59386931
84AMPK signaling pathway_Homo sapiens_hsa041520.59180230
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58150427
86Serotonergic synapse_Homo sapiens_hsa047260.55254416
87Vitamin B6 metabolism_Homo sapiens_hsa007500.54892435
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54073477
89Cocaine addiction_Homo sapiens_hsa050300.52462535
90cAMP signaling pathway_Homo sapiens_hsa040240.52338622
91Long-term depression_Homo sapiens_hsa047300.51525604
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48939830
93GnRH signaling pathway_Homo sapiens_hsa049120.48253853
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47427186
95Gap junction_Homo sapiens_hsa045400.46881393
96* Phenylalanine metabolism_Homo sapiens_hsa003600.45286791
97Sulfur metabolism_Homo sapiens_hsa009200.45238363
98One carbon pool by folate_Homo sapiens_hsa006700.45183626
99Insulin signaling pathway_Homo sapiens_hsa049100.44693328
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42112284
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42092583
102Fatty acid biosynthesis_Homo sapiens_hsa000610.41626292
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.41095460
104Galactose metabolism_Homo sapiens_hsa000520.40434915
105Proteasome_Homo sapiens_hsa030500.38708756
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.38666409
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35476513
108* Tyrosine metabolism_Homo sapiens_hsa003500.35063095
109Tight junction_Homo sapiens_hsa045300.34899692
110Pancreatic secretion_Homo sapiens_hsa049720.34650729
111Circadian rhythm_Homo sapiens_hsa047100.33362455
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.33324604
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33173037
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32848271
115* Arginine and proline metabolism_Homo sapiens_hsa003300.31084172
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30454942
117* Metabolic pathways_Homo sapiens_hsa011000.30135102
118Chemical carcinogenesis_Homo sapiens_hsa052040.29549560
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29156232
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28168100

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