ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium movement (GO:0003341)	6.76063730
2	axonemal dynein complex assembly (GO:0070286)	6.27330728
3	epithelial cilium movement (GO:0003351)	6.11152010
4	cilium or flagellum-dependent cell motility (GO:0001539)	5.98578130
5	GTP biosynthetic process (GO:0006183)	5.81914150
6	UTP biosynthetic process (GO:0006228)	5.73485500
7	UTP metabolic process (GO:0046051)	5.08636776
8	nucleoside diphosphate phosphorylation (GO:0006165)	5.07683508
9	axoneme assembly (GO:0035082)	4.73586035
10	guanosine-containing compound biosynthetic process (GO:1901070)	4.73274781
11	ventricular system development (GO:0021591)	4.70670975
12	piRNA metabolic process (GO:0034587)	4.69865303
13	motile cilium assembly (GO:0044458)	4.57925064
14	fusion of sperm to egg plasma membrane (GO:0007342)	4.55206444
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.47588595
16	sperm-egg recognition (GO:0035036)	4.45168251
17	binding of sperm to zona pellucida (GO:0007339)	4.40619689
18	synaptonemal complex organization (GO:0070193)	4.34177873
19	regulation of cilium movement (GO:0003352)	4.33274753
20	synaptonemal complex assembly (GO:0007130)	4.23044314
21	sperm motility (GO:0030317)	4.17865328
22	spermatid development (GO:0007286)	4.16421118
23	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	4.11629149
24	cell wall macromolecule catabolic process (GO:0016998)	4.06089366
25	cell wall macromolecule metabolic process (GO:0044036)	4.06089366
26	CTP metabolic process (GO:0046036)	4.06088445
27	CTP biosynthetic process (GO:0006241)	4.06088445
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.90863698
29	chaperone-mediated protein complex assembly (GO:0051131)	3.89521765
30	mitotic metaphase plate congression (GO:0007080)	3.88797769
31	DNA replication-dependent nucleosome organization (GO:0034723)	3.88624224
32	DNA replication-dependent nucleosome assembly (GO:0006335)	3.88624224
33	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.87876885
34	cell-cell recognition (GO:0009988)	3.87796652
35	male meiosis (GO:0007140)	3.87180353
36	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.73108628
37	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.55406471
38	multicellular organism reproduction (GO:0032504)	3.55176448
39	nuclear pore organization (GO:0006999)	3.53990186
40	microtubule depolymerization (GO:0007019)	3.53638975
41	ribosome assembly (GO:0042255)	3.52920233
42	DNA methylation involved in gamete generation (GO:0043046)	3.51280730
43	protein localization to chromosome, centromeric region (GO:0071459)	3.50047493
44	male meiosis I (GO:0007141)	3.45950285
45	protein localization to kinetochore (GO:0034501)	3.44717600
46	mitotic sister chromatid segregation (GO:0000070)	3.42277537
47	meiotic nuclear division (GO:0007126)	3.41937740
48	ribosome biogenesis (GO:0042254)	3.41467229
49	DNA replication initiation (GO:0006270)	3.39882770
50	regulation of gene silencing by RNA (GO:0060966)	3.39123165
51	regulation of posttranscriptional gene silencing (GO:0060147)	3.39123165
52	regulation of gene silencing by miRNA (GO:0060964)	3.39123165
53	nuclear pore complex assembly (GO:0051292)	3.37978481
54	regulation of centrosome cycle (GO:0046605)	3.37222132
55	purine nucleobase biosynthetic process (GO:0009113)	3.34972474
56	protein K6-linked ubiquitination (GO:0085020)	3.32257689
57	nucleobase biosynthetic process (GO:0046112)	3.30921219
58	meiosis I (GO:0007127)	3.30700375
59	plasma membrane fusion (GO:0045026)	3.28432047
60	metaphase plate congression (GO:0051310)	3.27398064
61	formation of translation preinitiation complex (GO:0001731)	3.21687644
62	chromosome organization involved in meiosis (GO:0070192)	3.19680100
63	acrosome assembly (GO:0001675)	3.16974090
64	mitotic nuclear envelope disassembly (GO:0007077)	3.16636186
65	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.15195340
66	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.12511905
67	DNA replication checkpoint (GO:0000076)	3.07349213
68	regulation of meiosis I (GO:0060631)	3.04031669
69	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.02579376
70	regulation of centriole replication (GO:0046599)	2.98962449
71	regulation of spindle organization (GO:0090224)	2.98295904
72	nucleotide phosphorylation (GO:0046939)	2.97919752
73	positive regulation of chromosome segregation (GO:0051984)	2.97554268
74	regulation of telomere maintenance via telomerase (GO:0032210)	2.96497893
75	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.96223467
76	establishment of chromosome localization (GO:0051303)	2.95351538
77	chromosome condensation (GO:0030261)	2.94978862
78	rRNA modification (GO:0000154)	2.93586881
79	nuclear envelope disassembly (GO:0051081)	2.92505284
80	membrane disassembly (GO:0030397)	2.92505284
81	meiotic cell cycle (GO:0051321)	2.92491354
82	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.91946744
83	acrosome reaction (GO:0007340)	2.90657284
84	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.90522090
85	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.90522090
86	intra-S DNA damage checkpoint (GO:0031573)	2.88915034
87	regulation of chromosome segregation (GO:0051983)	2.88846434
88	meiotic cell cycle process (GO:1903046)	2.86978004
89	blastocyst development (GO:0001824)	2.86604032
90	ribonucleoprotein complex biogenesis (GO:0022613)	2.86015498
91	reproduction (GO:0000003)	2.85695215
92	male gamete generation (GO:0048232)	2.85665624
93	spermatogenesis (GO:0007283)	2.85538907
94	regulation of microtubule-based movement (GO:0060632)	2.84033997
95	histone exchange (GO:0043486)	2.83171194
96	sister chromatid segregation (GO:0000819)	2.81189939
97	microtubule bundle formation (GO:0001578)	2.79653750
98	pore complex assembly (GO:0046931)	2.78733641
99	single fertilization (GO:0007338)	2.77835665
100	maturation of SSU-rRNA (GO:0030490)	2.76419363

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.63671281
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	5.26984663
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.56375746
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.53616414
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.21427222
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.21427222
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.21427222
8	MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.06937195
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.01427433
10	* SMAD1_18555785_ChIP-Seq_MESCs_Mouse	2.99121347
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.59587140
12	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.55321861
13	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.54177313
14	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	2.52590397
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44340710
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38299635
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.35851845
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.35597279
19	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	2.27918384
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.27278770
21	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.26678930
22	NANOG_18555785_ChIP-Seq_MESCs_Mouse	2.25709755
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.25632689
24	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.16877978
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.15860814
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.13508283
27	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.11685388
28	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.06805719
29	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.06406300
30	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	2.05623434
31	STAT3_1855785_ChIP-Seq_MESCs_Mouse	2.01811989
32	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.99101290
33	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.91959184
34	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.86169501
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.83900743
36	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.78285643
37	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.76702517
38	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.73119168
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.70516397
40	AR_21909140_ChIP-Seq_LNCAP_Human	1.68821660
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.68292366
42	XRN2_22483619_ChIP-Seq_HELA_Human	1.67784091
43	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.66575841
44	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.64648436
45	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.62355279
46	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.60565880
47	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.60532968
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58837073
49	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.58250601
50	* KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.56190195
51	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.54377710
52	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.53168259
53	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.42612430
54	GABP_19822575_ChIP-Seq_HepG2_Human	1.42086545
55	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.41171743
56	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.41150350
57	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.40805505
58	TTF2_22483619_ChIP-Seq_HELA_Human	1.40755199
59	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.37643867
60	NANOG_18692474_ChIP-Seq_MEFs_Mouse	1.35857044
61	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.34777056
62	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.33368728
63	FOXP3_21729870_ChIP-Seq_TREG_Human	1.27882788
64	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.27048057
65	SOX2_18692474_ChIP-Seq_MEFs_Mouse	1.26471145
66	POU5F1_18692474_ChIP-Seq_MESCs_Mouse	1.23200697
67	POU5F1_16518401_ChIP-PET_MESCs_Mouse	1.23107719
68	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	1.22148490
69	NANOG_18692474_ChIP-Seq_MESCs_Mouse	1.21559274
70	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.21453416
71	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21051669
72	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.20893028
73	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.17931168
74	* SOX2_18692474_ChIP-Seq_MESCs_Mouse	1.17638496
75	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.15785345
76	* KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.14722709
77	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.13221758
78	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09064088
79	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.07330126
80	* SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.07304479
81	KAP1_27257070_Chip-Seq_ESCs_Mouse	1.06962404
82	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.06957477
83	KDM5A_27292631_Chip-Seq_BREAST_Human	1.01646987
84	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.00416004
85	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.99725411
86	TCF3_18347094_ChIP-ChIP_MESCs_Mouse	0.98614600
87	NANOG_16518401_ChIP-PET_MESCs_Mouse	0.95960766
88	ZNF263_19887448_ChIP-Seq_K562_Human	0.91923116
89	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.91686512
90	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.91216380
91	ELK1_19687146_ChIP-ChIP_HELA_Human	0.91179917
92	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.90977700
93	* SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.89870671
94	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.88292131
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.87370745
96	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.87306275
97	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.80612672
98	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.78108567
99	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.75228277
100	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.75070361

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.98502546
2	MP0002653_abnormal_ependyma_morphology	4.06068759
3	MP0003693_abnormal_embryo_hatching	4.02097764
4	MP0004957_abnormal_blastocyst_morpholog	3.99041032
5	MP0003111_abnormal_nucleus_morphology	3.82962863
6	MP0010094_abnormal_chromosome_stability	3.51467972
7	MP0008057_abnormal_DNA_replication	3.51438857
8	MP0008877_abnormal_DNA_methylation	3.40483020
9	MP0003077_abnormal_cell_cycle	3.03297096
10	MP0001929_abnormal_gametogenesis	2.96728340
11	MP0008058_abnormal_DNA_repair	2.82637678
12	MP0003698_abnormal_male_reproductive	2.82200339
13	MP0002210_abnormal_sex_determination	2.60811143
14	MP0003718_maternal_effect	2.57320220
15	MP0008932_abnormal_embryonic_tissue	2.49370930
16	MP0004133_heterotaxia	2.43582252
17	MP0003136_yellow_coat_color	2.36800853
18	MP0001145_abnormal_male_reproductive	2.28149071
19	MP0003786_premature_aging	2.15742802
20	MP0003123_paternal_imprinting	2.10496876
21	MP0005623_abnormal_meninges_morphology	2.10158384
22	MP0001730_embryonic_growth_arrest	1.98022622
23	MP0003806_abnormal_nucleotide_metabolis	1.91942234
24	MP0000653_abnormal_sex_gland	1.89003267
25	MP0003890_abnormal_embryonic-extraembry	1.83460163
26	MP0006292_abnormal_olfactory_placode	1.83432046
27	MP0000350_abnormal_cell_proliferation	1.79459553
28	MP0002161_abnormal_fertility/fecundity	1.75604834
29	MP0002160_abnormal_reproductive_system	1.72140047
30	MP0005380_embryogenesis_phenotype	1.66829480
31	MP0001672_abnormal_embryogenesis/_devel	1.66829480
32	MP0002084_abnormal_developmental_patter	1.65843806
33	MP0002085_abnormal_embryonic_tissue	1.63143015
34	MP0001293_anophthalmia	1.57592194
35	MP0008007_abnormal_cellular_replicative	1.50442823
36	MP0003941_abnormal_skin_development	1.46282136
37	MP0001697_abnormal_embryo_size	1.45943913
38	MP0005670_abnormal_white_adipose	1.38152736
39	MP0003984_embryonic_growth_retardation	1.34110251
40	MP0002088_abnormal_embryonic_growth/wei	1.32700398
41	MP0002080_prenatal_lethality	1.30378250
42	MP0010352_gastrointestinal_tract_polyps	1.29451255
43	MP0003121_genomic_imprinting	1.27422425
44	MP0005389_reproductive_system_phenotype	1.27159592
45	MP0003315_abnormal_perineum_morphology	1.26370678
46	MP0006035_abnormal_mitochondrial_morpho	1.22653960
47	MP0004197_abnormal_fetal_growth/weight/	1.20613366
48	MP0003119_abnormal_digestive_system	1.19501943
49	MP0002086_abnormal_extraembryonic_tissu	1.19414694
50	MP0003937_abnormal_limbs/digits/tail_de	1.15002485
51	MP0010307_abnormal_tumor_latency	1.10943313
52	MP0005395_other_phenotype	1.06228346
53	MP0004264_abnormal_extraembryonic_tissu	1.01871542
54	MP0000358_abnormal_cell_content/	1.01328952
55	MP0005266_abnormal_metabolism	0.98596868
56	MP0003938_abnormal_ear_development	0.97731178
57	MP0000428_abnormal_craniofacial_morphol	0.95546640
58	MP0000313_abnormal_cell_death	0.93534668
59	MP0008004_abnormal_stomach_pH	0.93407978
60	MP0005377_hearing/vestibular/ear_phenot	0.93079490
61	MP0003878_abnormal_ear_physiology	0.93079490
62	MP0002092_abnormal_eye_morphology	0.91453785
63	MP0003861_abnormal_nervous_system	0.89661910
64	MP0001440_abnormal_grooming_behavior	0.89241544
65	MP0001849_ear_inflammation	0.86890405
66	MP0000750_abnormal_muscle_regeneration	0.85889562
67	MP0003936_abnormal_reproductive_system	0.82479597
68	MP0001286_abnormal_eye_development	0.80224716
69	MP0003646_muscle_fatigue	0.79889995
70	MP0004233_abnormal_muscle_weight	0.79183335
71	MP0002269_muscular_atrophy	0.76768267
72	MP0001727_abnormal_embryo_implantation	0.76146286
73	MP0002111_abnormal_tail_morphology	0.75346273
74	MP0005499_abnormal_olfactory_system	0.75158147
75	MP0005394_taste/olfaction_phenotype	0.75158147
76	MP0002332_abnormal_exercise_endurance	0.74564305
77	MP0003567_abnormal_fetal_cardiomyocyte	0.73233352
78	MP0002282_abnormal_trachea_morphology	0.71344192
79	MP0005391_vision/eye_phenotype	0.71120375
80	MP0009703_decreased_birth_body	0.70987267
81	MP0000432_abnormal_head_morphology	0.70708570
82	MP0008260_abnormal_autophagy	0.69456298
83	MP0008995_early_reproductive_senescence	0.68487084
84	MP0002796_impaired_skin_barrier	0.68140579
85	MP0001119_abnormal_female_reproductive	0.65452378
86	MP0003699_abnormal_female_reproductive	0.65051245
87	MP0006036_abnormal_mitochondrial_physio	0.63099011
88	MP0002019_abnormal_tumor_incidence	0.62448072
89	MP0006072_abnormal_retinal_apoptosis	0.62019126
90	MP0000762_abnormal_tongue_morphology	0.62004250
91	MP0003283_abnormal_digestive_organ	0.61642882
92	MP0002127_abnormal_cardiovascular_syste	0.61174923
93	MP0003755_abnormal_palate_morphology	0.60768944
94	MP0003186_abnormal_redox_activity	0.60677641
95	MP0005384_cellular_phenotype	0.60625885
96	MP0001919_abnormal_reproductive_system	0.60283853
97	MP0010030_abnormal_orbit_morphology	0.58426876
98	MP0002114_abnormal_axial_skeleton	0.57270264
99	MP0002249_abnormal_larynx_morphology	0.56391307
100	MP0000049_abnormal_middle_ear	0.53736373

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	8.36622969
2	Abnormal ciliary motility (HP:0012262)	7.34535578
3	Rhinitis (HP:0012384)	7.32496901
4	Abnormal respiratory motile cilium morphology (HP:0005938)	7.22415132
5	Abnormal respiratory epithelium morphology (HP:0012253)	7.22415132
6	Absent/shortened dynein arms (HP:0200106)	7.11527583
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.11527583
8	Chronic bronchitis (HP:0004469)	5.74526657
9	Supernumerary spleens (HP:0009799)	3.64012665
10	Bronchiectasis (HP:0002110)	3.48520899
11	Nasal polyposis (HP:0100582)	3.21945347
12	Impulsivity (HP:0100710)	3.21550435
13	Pancreatic fibrosis (HP:0100732)	3.01633033
14	Infertility (HP:0000789)	2.86163507
15	Abdominal situs inversus (HP:0003363)	2.81888050
16	Abnormality of abdominal situs (HP:0011620)	2.81888050
17	Breast hypoplasia (HP:0003187)	2.78002741
18	Abnormality of the labia minora (HP:0012880)	2.66065320
19	Pancreatic cysts (HP:0001737)	2.64836392
20	Nephronophthisis (HP:0000090)	2.64317908
21	Ependymoma (HP:0002888)	2.62805752
22	Bronchitis (HP:0012387)	2.60816505
23	Molar tooth sign on MRI (HP:0002419)	2.55560031
24	Abnormality of midbrain morphology (HP:0002418)	2.55560031
25	True hermaphroditism (HP:0010459)	2.55206309
26	Birth length less than 3rd percentile (HP:0003561)	2.53665804
27	Male infertility (HP:0003251)	2.52722851
28	Recurrent sinusitis (HP:0011108)	2.49431278
29	Carpal bone hypoplasia (HP:0001498)	2.47475890
30	Absent radius (HP:0003974)	2.46290718
31	Facial cleft (HP:0002006)	2.43037148
32	Abnormality of the nasal mucosa (HP:0000433)	2.42466303
33	Aplasia/hypoplasia of the humerus (HP:0006507)	2.41922412
34	Absent forearm bone (HP:0003953)	2.30513388
35	Aplasia involving forearm bones (HP:0009822)	2.30513388
36	Occipital encephalocele (HP:0002085)	2.27344492
37	Tubular atrophy (HP:0000092)	2.21140340
38	Rough bone trabeculation (HP:0100670)	2.20649926
39	Oral leukoplakia (HP:0002745)	2.17578549
40	Abnormal spermatogenesis (HP:0008669)	2.17367402
41	Tubulointerstitial nephritis (HP:0001970)	2.17351838
42	Bile duct proliferation (HP:0001408)	2.17123018
43	Abnormal biliary tract physiology (HP:0012439)	2.17123018
44	Selective tooth agenesis (HP:0001592)	2.13755383
45	Rib fusion (HP:0000902)	2.13174795
46	Concave nail (HP:0001598)	2.10251430
47	Short humerus (HP:0005792)	2.09601434
48	Abnormal umbilical cord blood vessels (HP:0011403)	2.07404615
49	Single umbilical artery (HP:0001195)	2.07404615
50	Abnormality of the fetal cardiovascular system (HP:0010948)	2.07404615
51	Abnormal ventriculo-arterial connection (HP:0011563)	2.06139587
52	Transposition of the great arteries (HP:0001669)	2.06139587
53	Abnormal connection of the cardiac segments (HP:0011545)	2.06139587
54	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.01427977
55	Meckel diverticulum (HP:0002245)	2.01065444
56	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	10.3173468
57	Missing ribs (HP:0000921)	1.97481768
58	Median cleft lip (HP:0000161)	1.96906810
59	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.96806469
60	Cerebral hypomyelination (HP:0006808)	1.95540109
61	Chromsome breakage (HP:0040012)	1.94323953
62	Postaxial foot polydactyly (HP:0001830)	1.92360654
63	Anencephaly (HP:0002323)	1.92001460
64	Abnormality of the ileum (HP:0001549)	1.91579925
65	Abnormality of the lower motor neuron (HP:0002366)	1.90662410
66	Cystic liver disease (HP:0006706)	1.89678529
67	Sloping forehead (HP:0000340)	1.86705433
68	Premature ovarian failure (HP:0008209)	1.85992022
69	Recurrent otitis media (HP:0000403)	1.85834430
70	Broad distal phalanx of finger (HP:0009836)	1.84743015
71	Rhabdomyosarcoma (HP:0002859)	1.83014365
72	Abnormality of the anterior horn cell (HP:0006802)	1.82511362
73	Degeneration of anterior horn cells (HP:0002398)	1.82511362
74	Medulloblastoma (HP:0002885)	1.79383504
75	Abnormality of the umbilical cord (HP:0010881)	1.77601773
76	Patellar aplasia (HP:0006443)	1.76642234
77	Shawl scrotum (HP:0000049)	1.76415285
78	Abnormality of the renal medulla (HP:0100957)	1.74178090
79	Sclerocornea (HP:0000647)	1.71592588
80	Congenital hepatic fibrosis (HP:0002612)	1.68757544
81	Abnormality of dentin (HP:0010299)	1.68047815
82	Neoplasm of the oral cavity (HP:0100649)	1.67471094
83	Abnormality of the astrocytes (HP:0100707)	1.67215782
84	Astrocytoma (HP:0009592)	1.67215782
85	Aplasia/Hypoplasia of the patella (HP:0006498)	1.66443220
86	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.66091518
87	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.65937043
88	Abnormality of the preputium (HP:0100587)	1.65707047
89	Multiple enchondromatosis (HP:0005701)	1.65560120
90	11 pairs of ribs (HP:0000878)	1.65539809
91	Medial flaring of the eyebrow (HP:0010747)	1.65508118
92	Cleft eyelid (HP:0000625)	1.64631245
93	Nephroblastoma (Wilms tumor) (HP:0002667)	1.64328173
94	Rectal fistula (HP:0100590)	1.63471715
95	Rectovaginal fistula (HP:0000143)	1.63471715
96	Secondary amenorrhea (HP:0000869)	1.62310998
97	Azoospermia (HP:0000027)	1.62239844
98	Oculomotor apraxia (HP:0000657)	1.59586200
99	Amyotrophic lateral sclerosis (HP:0007354)	1.58152541
100	Bone marrow hypocellularity (HP:0005528)	1.57043575

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.27743991
2	WEE1	5.18107450
3	BUB1	4.23871043
4	PDK3	3.69364117
5	PDK4	3.69364117
6	TTK	2.94996759
7	EPHA2	2.66559010
8	PDK2	2.57374959
9	CDK12	2.39604233
10	CDC7	2.37509099
11	NEK2	2.37143806
12	TSSK6	2.17890845
13	NEK1	2.12425799
14	MAPK15	1.97268977
15	PLK1	1.96783364
16	PLK4	1.89889958
17	TESK1	1.71662284
18	SRPK1	1.68548525
19	CHEK2	1.57626286
20	VRK1	1.52664166
21	AKT3	1.51245850
22	PLK3	1.50065556
23	DYRK3	1.42840721
24	BRSK2	1.39565556
25	EIF2AK1	1.37637678
26	ICK	1.37166572
27	ACVR1B	1.36697979
28	AURKA	1.36370012
29	MKNK2	1.33889490
30	CDK7	1.26847793
31	STK16	1.23443353
32	CHEK1	1.13398174
33	AURKB	1.04727455
34	LATS2	1.04663133
35	RPS6KB2	1.00947682
36	GRK1	0.98653942
37	ATR	0.96741836
38	PRKD3	0.91947346
39	MKNK1	0.91726766
40	BRAF	0.86978761
41	TESK2	0.85573808
42	ALK	0.84262396
43	MAP3K8	0.84179806
44	STK38L	0.83038215
45	EIF2AK3	0.81729734
46	ARAF	0.81457466
47	PASK	0.79038200
48	STK10	0.77446723
49	PAK4	0.77339739
50	BRSK1	0.77198149
51	CDK4	0.76437114
52	PRKCI	0.75666086
53	ATM	0.75000709
54	TYRO3	0.73917098
55	GRK5	0.73003479
56	CSNK1E	0.72674276
57	CDK2	0.72395235
58	ZAK	0.71640423
59	NME2	0.71417830
60	TLK1	0.70093773
61	CSNK2A2	0.65317586
62	PAK1	0.64750314
63	DYRK2	0.64649923
64	STK38	0.63226829
65	STK3	0.59507394
66	CSNK2A1	0.59247022
67	SCYL2	0.58678975
68	MAP3K9	0.55216224
69	CDK1	0.55131136
70	MTOR	0.54947158
71	GRK6	0.51694475
72	PBK	0.48845709
73	MAPKAPK3	0.46377866
74	WNK3	0.44385781
75	PINK1	0.43150240
76	PIM1	0.40712281
77	NME1	0.40162939
78	TGFBR1	0.38972874
79	PAK2	0.37460785
80	ADRBK2	0.35917032
81	PRKDC	0.35306806
82	PIM2	0.35155604
83	RPS6KA5	0.34417282
84	PRKCG	0.33947941
85	CCNB1	0.33617393
86	AKT2	0.32494323
87	CDK8	0.32113504
88	CSNK1D	0.30783843
89	BCR	0.29670739
90	MST4	0.28513874
91	MAPK10	0.27075016
92	CDK6	0.26963791
93	STK4	0.26572949
94	MELK	0.26556190
95	EEF2K	0.25858873
96	GSK3B	0.24913708
97	BCKDK	0.24435973
98	EIF2AK2	0.17561108
99	PTK2B	0.17453127
100	MOS	0.17452148

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.10530222
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	4.04824871
3	Proteasome_Homo sapiens_hsa03050	3.75976676
4	Mismatch repair_Homo sapiens_hsa03430	3.69476333
5	DNA replication_Homo sapiens_hsa03030	3.65596769
6	RNA transport_Homo sapiens_hsa03013	3.48410061
7	RNA polymerase_Homo sapiens_hsa03020	3.23298472
8	Spliceosome_Homo sapiens_hsa03040	2.84291788
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.76543256
10	Homologous recombination_Homo sapiens_hsa03440	2.74448483
11	Ribosome_Homo sapiens_hsa03010	2.64101737
12	Basal transcription factors_Homo sapiens_hsa03022	2.56692875
13	Pyrimidine metabolism_Homo sapiens_hsa00240	2.54838352
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.49970318
15	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.35035917
16	Cell cycle_Homo sapiens_hsa04110	2.28029690
17	Base excision repair_Homo sapiens_hsa03410	2.14599582
18	One carbon pool by folate_Homo sapiens_hsa00670	1.76845822
19	mRNA surveillance pathway_Homo sapiens_hsa03015	1.71458735
20	Purine metabolism_Homo sapiens_hsa00230	1.69534693
21	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.69180339
22	Huntingtons disease_Homo sapiens_hsa05016	1.66362641
23	Oocyte meiosis_Homo sapiens_hsa04114	1.57321557
24	RNA degradation_Homo sapiens_hsa03018	1.55981921
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.42789557
26	Pentose phosphate pathway_Homo sapiens_hsa00030	1.41528904
27	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.39997669
28	p53 signaling pathway_Homo sapiens_hsa04115	1.34936611
29	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.30146279
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.21274153
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.19918046
32	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.08246916
33	Regulation of autophagy_Homo sapiens_hsa04140	1.07027853
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05315048
35	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.04453084
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99890286
37	Glutathione metabolism_Homo sapiens_hsa00480	0.98269075
38	Selenocompound metabolism_Homo sapiens_hsa00450	0.98227058
39	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.96361567
40	Carbon metabolism_Homo sapiens_hsa01200	0.96153217
41	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.95803523
42	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.95112735
43	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.89500998
44	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.88076232
45	Folate biosynthesis_Homo sapiens_hsa00790	0.85555932
46	Pyruvate metabolism_Homo sapiens_hsa00620	0.83906940
47	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.80138131
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77204581
49	Hippo signaling pathway_Homo sapiens_hsa04390	0.73843427
50	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.72796723
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.65910175
52	Basal cell carcinoma_Homo sapiens_hsa05217	0.64828033
53	Oxidative phosphorylation_Homo sapiens_hsa00190	0.64420162
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.63785870
55	Antigen processing and presentation_Homo sapiens_hsa04612	0.63434806
56	Parkinsons disease_Homo sapiens_hsa05012	0.62406632
57	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.61298543
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59457131
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58865605
60	Metabolic pathways_Homo sapiens_hsa01100	0.50277661
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48901878
62	Viral carcinogenesis_Homo sapiens_hsa05203	0.48603503
63	Galactose metabolism_Homo sapiens_hsa00052	0.48006439
64	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.46097239
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46054579
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.45700806
67	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.44042724
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42114131
69	Tight junction_Homo sapiens_hsa04530	0.40487428
70	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39366547
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.39040129
72	HTLV-I infection_Homo sapiens_hsa05166	0.35320997
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.32127427
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31034920
75	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.29006988
76	Glucagon signaling pathway_Homo sapiens_hsa04922	0.22836717
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.21999910
78	Propanoate metabolism_Homo sapiens_hsa00640	0.21888793
79	mTOR signaling pathway_Homo sapiens_hsa04150	0.21565771
80	Alcoholism_Homo sapiens_hsa05034	0.20451270
81	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.18305400
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.18109209
83	Renin-angiotensin system_Homo sapiens_hsa04614	0.17356225
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.15360307
85	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.13373053
86	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.13141549
87	AMPK signaling pathway_Homo sapiens_hsa04152	0.11158750
88	MicroRNAs in cancer_Homo sapiens_hsa05206	0.08762450
89	Mineral absorption_Homo sapiens_hsa04978	0.07925058
90	Pathways in cancer_Homo sapiens_hsa05200	0.07244589
91	Alzheimers disease_Homo sapiens_hsa05010	0.05864454
92	Circadian rhythm_Homo sapiens_hsa04710	0.05805566
93	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.02407512
94	Retinol metabolism_Homo sapiens_hsa00830	0.02028424
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.02000140
96	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.01747621
97	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.00904306
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.00618578
99	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.00567479
100	Estrogen signaling pathway_Homo sapiens_hsa04915	-0.0039309

GOT1L1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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