GOT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine catabolic process (GO:0006554)5.91781694
2lysine metabolic process (GO:0006553)5.91781694
3L-phenylalanine catabolic process (GO:0006559)5.77796233
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.77796233
5L-phenylalanine metabolic process (GO:0006558)5.76655513
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.76655513
7glyoxylate metabolic process (GO:0046487)5.48259504
8aromatic amino acid family catabolic process (GO:0009074)5.03793656
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.01922221
10alpha-linolenic acid metabolic process (GO:0036109)4.95843061
11actin-myosin filament sliding (GO:0033275)4.91556108
12muscle filament sliding (GO:0030049)4.91556108
13cellular ketone body metabolic process (GO:0046950)4.67757871
14* 2-oxoglutarate metabolic process (GO:0006103)4.57846407
15negative regulation of fibrinolysis (GO:0051918)4.55203230
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.50414840
17* kynurenine metabolic process (GO:0070189)4.46894739
18cysteine metabolic process (GO:0006534)4.46727291
19bile acid biosynthetic process (GO:0006699)4.44979278
20tryptophan catabolic process (GO:0006569)4.43752252
21indole-containing compound catabolic process (GO:0042436)4.43752252
22indolalkylamine catabolic process (GO:0046218)4.43752252
23* aspartate family amino acid catabolic process (GO:0009068)4.38769863
24amino-acid betaine metabolic process (GO:0006577)4.35088572
25serine family amino acid catabolic process (GO:0009071)4.32676391
26tricarboxylic acid cycle (GO:0006099)4.30337236
27sarcoplasmic reticulum calcium ion transport (GO:0070296)4.25624827
28sulfur amino acid catabolic process (GO:0000098)4.25179372
29urea metabolic process (GO:0019627)4.23143523
30urea cycle (GO:0000050)4.23143523
31high-density lipoprotein particle remodeling (GO:0034375)4.21515722
32carnitine shuttle (GO:0006853)4.19367800
33fatty acid transmembrane transport (GO:1902001)4.17670108
34acetyl-CoA metabolic process (GO:0006084)4.15930457
35tryptophan metabolic process (GO:0006568)4.15361101
36regulation of triglyceride catabolic process (GO:0010896)4.13594605
37ketone body metabolic process (GO:1902224)4.11029171
38regulation of fibrinolysis (GO:0051917)4.10250263
39glycine metabolic process (GO:0006544)4.04902134
40fatty acid beta-oxidation (GO:0006635)4.02962093
41regulation of protein activation cascade (GO:2000257)4.02085399
42* alpha-amino acid catabolic process (GO:1901606)3.99164894
43protein carboxylation (GO:0018214)3.96001188
44peptidyl-glutamic acid carboxylation (GO:0017187)3.96001188
45actin-mediated cell contraction (GO:0070252)3.94018516
46homocysteine metabolic process (GO:0050667)3.93736045
47short-chain fatty acid metabolic process (GO:0046459)3.90851390
48nitrogen cycle metabolic process (GO:0071941)3.87070614
49ethanol oxidation (GO:0006069)3.85622042
50complement activation, alternative pathway (GO:0006957)3.85181690
51DNA unwinding involved in DNA replication (GO:0006268)3.80661388
52IMP metabolic process (GO:0046040)3.80385603
53* gluconeogenesis (GO:0006094)3.79216659
54* dicarboxylic acid biosynthetic process (GO:0043650)3.79197952
55* glutamate metabolic process (GO:0006536)3.75975406
56* cellular amino acid catabolic process (GO:0009063)3.75840259
57sarcomere organization (GO:0045214)3.74495860
58regulation of complement activation (GO:0030449)3.74017471
59fatty acid oxidation (GO:0019395)3.72546386
60positive regulation of fatty acid beta-oxidation (GO:0032000)3.70840804
61tricarboxylic acid metabolic process (GO:0072350)3.70725622
62aromatic amino acid family metabolic process (GO:0009072)3.68769322
63serine family amino acid metabolic process (GO:0009069)3.68393313
64bile acid metabolic process (GO:0008206)3.66664562
65negative regulation of sterol transport (GO:0032372)3.66264840
66negative regulation of cholesterol transport (GO:0032375)3.66264840
67carnitine metabolic process (GO:0009437)3.66060679
68reverse cholesterol transport (GO:0043691)3.65981956
69phospholipid homeostasis (GO:0055091)3.65845210
70regulation of translational fidelity (GO:0006450)3.64618371
71lipid oxidation (GO:0034440)3.63897570
72fatty acid catabolic process (GO:0009062)3.63395222
73plasma lipoprotein particle remodeling (GO:0034369)3.61029160
74protein-lipid complex remodeling (GO:0034368)3.61029160
75macromolecular complex remodeling (GO:0034367)3.61029160
76plasma lipoprotein particle clearance (GO:0034381)3.60876371
77acylglycerol homeostasis (GO:0055090)3.60692923
78triglyceride homeostasis (GO:0070328)3.60692923
79tyrosine metabolic process (GO:0006570)3.57590453
80regulation of fatty acid beta-oxidation (GO:0031998)3.55606529
81creatine metabolic process (GO:0006600)3.55392656
82negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.54377944
83IMP biosynthetic process (GO:0006188)3.52689967
84regulation of cholesterol homeostasis (GO:2000188)3.51227741
85L-serine metabolic process (GO:0006563)3.50697773
86cardiac myofibril assembly (GO:0055003)3.49726031
87* monocarboxylic acid catabolic process (GO:0072329)3.49311939
88* hexose biosynthetic process (GO:0019319)3.49225510
89establishment of integrated proviral latency (GO:0075713)3.48094458
90coenzyme catabolic process (GO:0009109)3.47852275
91regulation of fatty acid oxidation (GO:0046320)3.46440604
92serine family amino acid biosynthetic process (GO:0009070)3.45236997
93* carboxylic acid catabolic process (GO:0046395)3.43280857
94* organic acid catabolic process (GO:0016054)3.43280857
95regulation of cholesterol esterification (GO:0010872)3.41646671
96NADH metabolic process (GO:0006734)3.39075409
97positive regulation of lipid catabolic process (GO:0050996)3.38691000
98oxidative phosphorylation (GO:0006119)3.37473711
99skeletal muscle contraction (GO:0003009)3.34737538
100glycolytic process (GO:0006096)3.33674525
101negative regulation of fatty acid biosynthetic process (GO:0045717)3.33657829
102* cellular modified amino acid catabolic process (GO:0042219)3.32845001
103proline biosynthetic process (GO:0006561)3.32074916
104striated muscle contraction (GO:0006941)3.31455325
105DNA strand elongation involved in DNA replication (GO:0006271)3.30127236
106positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.28583871
107succinate metabolic process (GO:0006105)3.28293690
108positive regulation of fatty acid oxidation (GO:0046321)3.26523861
109valine metabolic process (GO:0006573)3.26385353
110* monosaccharide biosynthetic process (GO:0046364)3.26224126
111peptidyl-arginine omega-N-methylation (GO:0035247)3.25425039
112mitotic chromosome condensation (GO:0007076)3.24774779
113phospholipid efflux (GO:0033700)3.21272502
114negative regulation of potassium ion transmembrane transport (GO:1901380)3.20852890
115drug catabolic process (GO:0042737)3.20600429
116branched-chain amino acid catabolic process (GO:0009083)3.19754395
117fatty acid homeostasis (GO:0055089)3.19734300
118response to mercury ion (GO:0046689)3.19467023
119carnitine transmembrane transport (GO:1902603)3.16804861
120cardiac muscle contraction (GO:0060048)3.16026114
121carnitine transport (GO:0015879)3.16024963
122amino-acid betaine transport (GO:0015838)3.16024963
123DNA strand elongation (GO:0022616)3.14779264
124arginine metabolic process (GO:0006525)3.14584977
125plasma membrane repair (GO:0001778)3.11089674
126regulation of relaxation of muscle (GO:1901077)3.08890117
127mitochondrial fusion (GO:0008053)3.06427725
128myofibril assembly (GO:0030239)2.99456943
129regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.93841568
130protein complex localization (GO:0031503)2.93185732
131regulation of actin filament-based movement (GO:1903115)2.87099817
132ribosome assembly (GO:0042255)2.87075536
133histone arginine methylation (GO:0034969)2.86501410
134nuclear pore complex assembly (GO:0051292)2.86020995
135Golgi transport vesicle coating (GO:0048200)2.84293298
136COPI coating of Golgi vesicle (GO:0048205)2.84293298
137mitotic sister chromatid segregation (GO:0000070)2.83373034
138protein localization to chromosome, centromeric region (GO:0071459)2.83217857
139regulation of coenzyme metabolic process (GO:0051196)2.81131233
140regulation of cofactor metabolic process (GO:0051193)2.81131233
141actin filament-based movement (GO:0030048)2.80214827
142protein localization to kinetochore (GO:0034501)2.78360303
143tRNA aminoacylation for protein translation (GO:0006418)2.77539373
144telomere maintenance via semi-conservative replication (GO:0032201)2.77316842
145pyruvate metabolic process (GO:0006090)2.77280178
146regulation of mitochondrial translation (GO:0070129)2.75600387
147response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.74309959
148establishment of viral latency (GO:0019043)2.71103945
149regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.70841842
150regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.70104101
151formation of translation preinitiation complex (GO:0001731)2.69762204
152* oxaloacetate metabolic process (GO:0006107)2.68312057
153peptidyl-arginine methylation (GO:0018216)2.68106738
154peptidyl-arginine N-methylation (GO:0035246)2.68106738
155nuclear pore organization (GO:0006999)2.67819886
156amino acid activation (GO:0043038)2.67095142
157tRNA aminoacylation (GO:0043039)2.67095142
158nucleobase-containing small molecule interconversion (GO:0015949)2.64387746
159mitotic metaphase plate congression (GO:0007080)2.63366313
160regulation of cell communication by electrical coupling (GO:0010649)2.63241089
161actomyosin structure organization (GO:0031032)2.60201406
162purine nucleobase biosynthetic process (GO:0009113)2.59858738
163proline metabolic process (GO:0006560)2.58863443
164glycogen catabolic process (GO:0005980)2.57890353
165DNA replication initiation (GO:0006270)2.57538211
166sister chromatid segregation (GO:0000819)2.53808450
167folic acid-containing compound biosynthetic process (GO:0009396)2.53636723
168cellular protein complex localization (GO:0034629)2.48474877
169regulation of skeletal muscle contraction (GO:0014819)2.47867938
170regulation of translational elongation (GO:0006448)2.45989551
171nucleobase biosynthetic process (GO:0046112)2.45633792
172cardiac muscle cell development (GO:0055013)2.44228593
173glutamine metabolic process (GO:0006541)2.42449827
174response to muscle activity (GO:0014850)2.42190021
175glycogen biosynthetic process (GO:0005978)2.39868426
176glucan biosynthetic process (GO:0009250)2.39868426
177mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.39060107
178fructose metabolic process (GO:0006000)2.38078328
179ubiquinone biosynthetic process (GO:0006744)2.37766966
180spliceosomal tri-snRNP complex assembly (GO:0000244)2.37536918
181regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.36771944
182DNA replication checkpoint (GO:0000076)2.36100511
183regulation of acyl-CoA biosynthetic process (GO:0050812)2.34878408
184pteridine-containing compound biosynthetic process (GO:0042559)2.34572953
185ubiquinone metabolic process (GO:0006743)2.33669107
186cardiac muscle hypertrophy (GO:0003300)2.32311349
187AMP metabolic process (GO:0046033)2.31133293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.78285360
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.59372495
3E2F7_22180533_ChIP-Seq_HELA_Human6.52142868
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.30718617
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.94651401
6* LXR_22158963_ChIP-Seq_LIVER_Mouse5.06037633
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.11333811
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.88321087
9* MYC_18555785_ChIP-Seq_MESCs_Mouse3.88157093
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.67947496
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.50423591
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.16759999
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.09718914
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.06385764
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.92181138
16* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.77458541
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75114128
18ZNF263_19887448_ChIP-Seq_K562_Human2.73761801
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65242230
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64220726
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62488267
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61935658
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60346375
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49646079
25AR_21909140_ChIP-Seq_LNCAP_Human2.40577979
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39413527
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38987478
28XRN2_22483619_ChIP-Seq_HELA_Human2.36639955
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33273009
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33269183
31CLOCK_20551151_ChIP-Seq_293T_Human2.30362624
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29075274
33ZFX_18555785_ChIP-Seq_MESCs_Mouse2.24509860
34ETS1_20019798_ChIP-Seq_JURKAT_Human2.19216323
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17809881
36RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03275054
37* DCP1A_22483619_ChIP-Seq_HELA_Human2.03087525
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02265205
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02104950
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97923466
41* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.94822667
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90143884
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86399243
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82024646
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.80807718
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80270958
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79920571
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.79202345
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75143993
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74078650
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.73802181
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71185682
53GABP_19822575_ChIP-Seq_HepG2_Human1.70820635
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70356738
55LXR_22292898_ChIP-Seq_THP-1_Human1.68648220
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.67468284
57TTF2_22483619_ChIP-Seq_HELA_Human1.60723060
58* TBX20_22328084_ChIP-Seq_HEART_Mouse1.59803524
59* TBX20_22080862_ChIP-Seq_HEART_Mouse1.59803524
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59190704
61* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59126780
62* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.57355459
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.57106495
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57057183
65* FOXA2_19822575_ChIP-Seq_HepG2_Human1.56309275
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.55077242
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51983953
68* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46694675
69* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43461950
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.40556901
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.39242944
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37492233
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.35816324
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35325483
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34778126
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32846476
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31919326
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30713544
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30535053
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27509951
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25522613
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.24755808
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24378244
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24274948
85RACK7_27058665_Chip-Seq_MCF-7_Human1.23112948
86KDM5A_27292631_Chip-Seq_BREAST_Human1.21672850
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21615733
88* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21338293
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.20814450
90* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.19493858
91* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.19439589
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17796627
93* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16230960
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.16124489
95* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15210438
96ATF3_27146783_Chip-Seq_COLON_Human1.14137315
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13952953
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12208541
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11709278
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11241698
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08370087
102P68_20966046_ChIP-Seq_HELA_Human1.07700760
103* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06110441
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05597328
105FOXP3_21729870_ChIP-Seq_TREG_Human1.04585929
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03874783
107SOX17_20123909_ChIP-Seq_XEN_Mouse1.02760270
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.01710335
109CREB1_26743006_Chip-Seq_LNCaP_Human1.01060692
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00499157
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00271537
112KDM2B_26808549_Chip-Seq_DND41_Human0.99149746
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98552692
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98037507
115GATA1_22025678_ChIP-Seq_K562_Human0.97435524
116NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97353893
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97004917
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96338412
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95856746
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95131998
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93473065
122* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93285463
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93105948
124TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91954585
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91825450
126* CHD1_26751641_Chip-Seq_LNCaP_Human0.91444621
127HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91259456
128CIITA_25753668_ChIP-Seq_RAJI_Human0.91058543
129CTCF_27219007_Chip-Seq_Bcells_Human0.88922661
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88861693
131FOXP1_21924763_ChIP-Seq_HESCs_Human0.86834525
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86810310
133SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86536321
134ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86379411
135SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86195128
136RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85923692
137PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85901344
138EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85708572
139P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85599916
140RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85541070
141SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84764834
142BCOR_27268052_Chip-Seq_Bcells_Human0.84562008
143* MYC_22102868_ChIP-Seq_BL_Human0.83037579
144GATA1_19941826_ChIP-Seq_K562_Human0.82572875
145* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82092987
146FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81620438
147TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80490182
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.80313101
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.78262627
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78081973
151BCL6_27268052_Chip-Seq_Bcells_Human0.77459744
152* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77307051
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76816311
154PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74916707
155GATA4_21415370_ChIP-Seq_HL-1_Mouse0.74733016
156TP63_22573176_ChIP-Seq_HFKS_Human0.74466297
157UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.74425782
158CTCF_21964334_Chip-Seq_Bcells_Human0.74036030
159TET1_21451524_ChIP-Seq_MESCs_Mouse0.73274070
160ELF1_20517297_ChIP-Seq_JURKAT_Human0.72682929
161TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.72665892
162CTCF_21964334_ChIP-Seq_BJAB-B_Human0.72474136
163KDM2B_26808549_Chip-Seq_K562_Human0.71937147
164ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71934436
165SMC4_20622854_ChIP-Seq_HELA_Human0.70619981
166SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69989418
167SPI1_20517297_ChIP-Seq_HL60_Human0.69260089
168* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.69152004
169TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.67845155
170* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.67724856
171HIF1A_21447827_ChIP-Seq_MCF-7_Human0.67104454
172GATA6_25053715_ChIP-Seq_YYC3_Human0.66453076
173SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.65893214
174TCF7_22412390_ChIP-Seq_EML_Mouse0.65422596
175HTT_18923047_ChIP-ChIP_STHdh_Human0.65352122
176RARA_24833708_ChIP-Seq_LIVER_Mouse0.65310125
177SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65291898
178KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.65113653
179ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.64817024
180KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.64646530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.91628835
2MP0005360_urolithiasis5.59838668
3MP0005085_abnormal_gallbladder_physiolo4.82286682
4MP0002837_dystrophic_cardiac_calcinosis4.46514400
5MP0005365_abnormal_bile_salt4.36080419
6MP0003806_abnormal_nucleotide_metabolis3.81680848
7MP0008875_abnormal_xenobiotic_pharmacok3.46130572
8MP0003646_muscle_fatigue3.09747451
9MP0004084_abnormal_cardiac_muscle3.02085351
10MP0003252_abnormal_bile_duct2.86332749
11MP0000751_myopathy2.82520922
12MP0009840_abnormal_foam_cell2.79902625
13MP0010329_abnormal_lipoprotein_level2.68725816
14MP0003693_abnormal_embryo_hatching2.67683508
15MP0005083_abnormal_biliary_tract2.61646290
16MP0004215_abnormal_myocardial_fiber2.43425480
17MP0005330_cardiomyopathy2.37663954
18MP0004036_abnormal_muscle_relaxation2.33573391
19MP0005332_abnormal_amino_acid2.31626144
20MP0003111_abnormal_nucleus_morphology2.31362306
21MP0010094_abnormal_chromosome_stability2.25900784
22MP0003705_abnormal_hypodermis_morpholog2.22052560
23MP0004957_abnormal_blastocyst_morpholog2.07687831
24MP0004130_abnormal_muscle_cell2.04298776
25MP0003195_calcinosis2.01154043
26MP0000749_muscle_degeneration1.92215802
27MP0002269_muscular_atrophy1.87244990
28MP0004087_abnormal_muscle_fiber1.87178247
29MP0008932_abnormal_embryonic_tissue1.85214789
30MP0001661_extended_life_span1.75199869
31MP0001666_abnormal_nutrient_absorption1.73114495
32MP0006036_abnormal_mitochondrial_physio1.71620717
33MP0005319_abnormal_enzyme/_coenzyme1.71063520
34MP0003077_abnormal_cell_cycle1.70931889
35MP0002118_abnormal_lipid_homeostasis1.66451855
36MP0003191_abnormal_cellular_cholesterol1.63513665
37MP0000609_abnormal_liver_physiology1.62774866
38MP0001730_embryonic_growth_arrest1.59739859
39MP0002972_abnormal_cardiac_muscle1.58482672
40MP0003941_abnormal_skin_development1.58037778
41MP0004270_analgesia1.55711674
42MP0000747_muscle_weakness1.55383289
43MP0008775_abnormal_heart_ventricle1.55002111
44MP0010630_abnormal_cardiac_muscle1.52340986
45MP0008058_abnormal_DNA_repair1.48807767
46MP0003137_abnormal_impulse_conducting1.47900148
47MP0005385_cardiovascular_system_phenoty1.47240212
48MP0001544_abnormal_cardiovascular_syste1.47240212
49MP0005620_abnormal_muscle_contractility1.42993318
50MP0005584_abnormal_enzyme/coenzyme_acti1.40635281
51MP0001529_abnormal_vocalization1.39970159
52MP0004233_abnormal_muscle_weight1.37444909
53MP0006138_congestive_heart_failure1.35472204
54MP0000750_abnormal_muscle_regeneration1.34440032
55MP0003221_abnormal_cardiomyocyte_apopto1.32357522
56MP0001346_abnormal_lacrimal_gland1.25704010
57MP0004019_abnormal_vitamin_homeostasis1.25231087
58MP0010368_abnormal_lymphatic_system1.23599429
59MP0002106_abnormal_muscle_physiology1.21210385
60MP0005666_abnormal_adipose_tissue1.17576936
61MP0000579_abnormal_nail_morphology1.17307690
62MP0010030_abnormal_orbit_morphology1.16895754
63MP0006035_abnormal_mitochondrial_morpho1.15148753
64MP0003656_abnormal_erythrocyte_physiolo1.12321511
65MP0000013_abnormal_adipose_tissue1.11770596
66MP0004085_abnormal_heartbeat1.11017248
67MP0000733_abnormal_muscle_development1.10609355
68MP0009643_abnormal_urine_homeostasis1.09844143
69MP0000759_abnormal_skeletal_muscle1.09451842
70MP0002138_abnormal_hepatobiliary_system1.08933119
71MP0005266_abnormal_metabolism1.07704137
72MP0000003_abnormal_adipose_tissue1.07573853
73MP0005380_embryogenesis_phenotype1.07505373
74MP0001672_abnormal_embryogenesis/_devel1.07505373
75MP0000537_abnormal_urethra_morphology1.03028708
76MP0002080_prenatal_lethality1.02528766
77MP0005670_abnormal_white_adipose1.00133116
78MP0000350_abnormal_cell_proliferation0.99830017
79MP0008007_abnormal_cellular_replicative0.99374570
80MP0003984_embryonic_growth_retardation0.99276250
81MP0005451_abnormal_body_composition0.97712519
82MP0001697_abnormal_embryo_size0.96138367
83MP0001299_abnormal_eye_distance/0.95509276
84MP0003329_amyloid_beta_deposits0.95330211
85MP0003868_abnormal_feces_composition0.95237851
86MP0005369_muscle_phenotype0.95165136
87MP0003315_abnormal_perineum_morphology0.94759997
88MP0002822_catalepsy0.94557701
89MP0005623_abnormal_meninges_morphology0.94130152
90MP0004484_altered_response_of0.94120862
91MP0008057_abnormal_DNA_replication0.93872306
92MP0002088_abnormal_embryonic_growth/wei0.92179464
93MP0000598_abnormal_liver_morphology0.91787793
94MP0004145_abnormal_muscle_electrophysio0.91138303
95MP0002078_abnormal_glucose_homeostasis0.89924700
96MP0003718_maternal_effect0.88496552
97MP0002877_abnormal_melanocyte_morpholog0.87863970
98MP0004859_abnormal_synaptic_plasticity0.86455960
99MP0001764_abnormal_homeostasis0.85099501
100MP0000604_amyloidosis0.83773932
101MP0003123_paternal_imprinting0.83607026
102MP0000762_abnormal_tongue_morphology0.83329647
103MP0002332_abnormal_exercise_endurance0.81899118
104MP0008961_abnormal_basal_metabolism0.81011570
105MP0004197_abnormal_fetal_growth/weight/0.80992529
106MP0002127_abnormal_cardiovascular_syste0.80597929
107MP0002084_abnormal_developmental_patter0.80041600
108MP0000566_synostosis0.79632716
109MP0002085_abnormal_embryonic_tissue0.79406002
110MP0004185_abnormal_adipocyte_glucose0.76921861
111MP0005187_abnormal_penis_morphology0.75007150
112MP0002971_abnormal_brown_adipose0.73716274
113MP0000358_abnormal_cell_content/0.73592937
114MP0004043_abnormal_pH_regulation0.73045085
115MP0000467_abnormal_esophagus_morphology0.72727813
116MP0005375_adipose_tissue_phenotype0.71349066
117MP0003186_abnormal_redox_activity0.69424360
118MP0002108_abnormal_muscle_morphology0.69197256
119MP0003786_premature_aging0.67569359
120MP0002909_abnormal_adrenal_gland0.66976945
121MP0005376_homeostasis/metabolism_phenot0.66553931
122MP0003011_delayed_dark_adaptation0.65149857
123MP0005535_abnormal_body_temperature0.64604236
124MP0003567_abnormal_fetal_cardiomyocyte0.64566449
125MP0005636_abnormal_mineral_homeostasis0.63604852
126MP0004147_increased_porphyrin_level0.63542539
127MP0009642_abnormal_blood_homeostasis0.63423121
128MP0000266_abnormal_heart_morphology0.62716777
129MP0002697_abnormal_eye_size0.62593684
130MP0010352_gastrointestinal_tract_polyps0.62518785
131MP0005165_increased_susceptibility_to0.61122165
132MP0001756_abnormal_urination0.59284460
133MP0000230_abnormal_systemic_arterial0.59244030
134MP0005501_abnormal_skin_physiology0.58821320
135MP0009763_increased_sensitivity_to0.58216602
136MP0003566_abnormal_cell_adhesion0.57834558
137MP0008874_decreased_physiological_sensi0.57778888
138MP0009703_decreased_birth_body0.56731714
139MP0009672_abnormal_birth_weight0.56106358
140MP0005334_abnormal_fat_pad0.55630648
141MP0002128_abnormal_blood_circulation0.53949467
142MP0002234_abnormal_pharynx_morphology0.53232110
143MP0001727_abnormal_embryo_implantation0.52913675
144MP0009697_abnormal_copulation0.50198110
145MP0010234_abnormal_vibrissa_follicle0.44970390
146MP0009053_abnormal_anal_canal0.44125222
147MP0003828_pulmonary_edema0.43942908
148MP0004510_myositis0.43626102
149MP0002970_abnormal_white_adipose0.41028996
150MP0005448_abnormal_energy_balance0.39182224

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.54287089
2Nemaline bodies (HP:0003798)6.51756575
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.31453700
4Deep venous thrombosis (HP:0002625)5.23328727
5Intrahepatic cholestasis (HP:0001406)4.65082893
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.63352618
7Xanthomatosis (HP:0000991)4.47849486
8Type 1 muscle fiber predominance (HP:0003803)4.43968456
9Sudden death (HP:0001699)4.42789039
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.25706312
11Ketosis (HP:0001946)4.25279916
12Hyperammonemia (HP:0001987)4.20062415
13Hypobetalipoproteinemia (HP:0003563)4.15340413
14Myoglobinuria (HP:0002913)4.03888179
15Abnormality of glycolysis (HP:0004366)4.02467079
16Hypoglycemic coma (HP:0001325)3.95175876
17Exercise-induced muscle cramps (HP:0003710)3.94751574
18Myopathic facies (HP:0002058)3.92417183
19Ketoacidosis (HP:0001993)3.86882351
20Increased serum pyruvate (HP:0003542)3.66391727
21Exercise-induced myalgia (HP:0003738)3.65827161
22Centrally nucleated skeletal muscle fibers (HP:0003687)3.64072352
23Hyperlipoproteinemia (HP:0010980)3.62739250
24Ventricular tachycardia (HP:0004756)3.56014511
25Hypolipoproteinemia (HP:0010981)3.53068095
26Progressive muscle weakness (HP:0003323)3.52083902
27Rimmed vacuoles (HP:0003805)3.48444989
28Hyperglycinuria (HP:0003108)3.47874690
29Abnormality of fatty-acid metabolism (HP:0004359)3.42785914
30Hypoalphalipoproteinemia (HP:0003233)3.42352735
31Abnormality of serine family amino acid metabolism (HP:0010894)3.39508651
32Abnormality of glycine metabolism (HP:0010895)3.39508651
33Prolonged partial thromboplastin time (HP:0003645)3.37623890
34Hyperglycinemia (HP:0002154)3.35018127
35Right ventricular cardiomyopathy (HP:0011663)3.21869812
36Complement deficiency (HP:0004431)3.19966932
37Rhabdomyolysis (HP:0003201)3.10104967
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.09770044
39Calf muscle hypertrophy (HP:0008981)3.05420909
40Hyporeflexia of lower limbs (HP:0002600)3.03416829
41Distal lower limb muscle weakness (HP:0009053)3.03245427
42Neck muscle weakness (HP:0000467)2.99615079
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.97830267
44Cholelithiasis (HP:0001081)2.96096717
45Epidermoid cyst (HP:0200040)2.89990595
46Abnormality of sulfur amino acid metabolism (HP:0004339)2.86656037
47Gout (HP:0001997)2.83842895
48Palpitations (HP:0001962)2.82799267
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.82679277
50Calcaneovalgus deformity (HP:0001848)2.82075764
51Muscle fiber splitting (HP:0003555)2.81929504
52Dicarboxylic aciduria (HP:0003215)2.81000875
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.81000875
54Distal arthrogryposis (HP:0005684)2.78855559
55Abnormality of the common coagulation pathway (HP:0010990)2.76261987
56Abnormal gallbladder morphology (HP:0012437)2.76061975
57Abnormal gallbladder physiology (HP:0012438)2.75926669
58Cholecystitis (HP:0001082)2.75926669
59Muscle hypertrophy of the lower extremities (HP:0008968)2.75360434
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.73653679
61Asymmetric septal hypertrophy (HP:0001670)2.70084450
62Atrioventricular block (HP:0001678)2.69999102
63Skin nodule (HP:0200036)2.66490611
64Atrial fibrillation (HP:0005110)2.66164882
65Lipoatrophy (HP:0100578)2.64973317
66Cerebral edema (HP:0002181)2.64558156
67Abnormality of methionine metabolism (HP:0010901)2.59160412
68Metabolic acidosis (HP:0001942)2.57163611
69Bundle branch block (HP:0011710)2.54266190
70Increased connective tissue (HP:0009025)2.51755430
71Primary atrial arrhythmia (HP:0001692)2.51105836
72Abnormality of the calf musculature (HP:0001430)2.50711882
73Syncope (HP:0001279)2.49286076
74Limb-girdle muscle atrophy (HP:0003797)2.47475992
75Hyperbilirubinemia (HP:0002904)2.45986652
76Round ear (HP:0100830)2.45686161
77Abnormality of skeletal muscle fiber size (HP:0012084)2.45281379
78Ragged-red muscle fibers (HP:0003200)2.44437467
79Supraventricular tachycardia (HP:0004755)2.43725941
80Deformed tarsal bones (HP:0008119)2.40876092
81Heart block (HP:0012722)2.40816033
82EMG: myopathic abnormalities (HP:0003458)2.40031294
83Neonatal onset (HP:0003623)2.39585893
84Subaortic stenosis (HP:0001682)2.39585171
85Abnormality of the left ventricular outflow tract (HP:0011103)2.39585171
86Supraventricular arrhythmia (HP:0005115)2.39582396
87Joint hemorrhage (HP:0005261)2.39332282
88Delayed CNS myelination (HP:0002188)2.37824580
89Distal lower limb amyotrophy (HP:0008944)2.37703077
90Late onset (HP:0003584)2.37474379
91Abnormality of serum amino acid levels (HP:0003112)2.36785982
92Dilated cardiomyopathy (HP:0001644)2.34867578
93Lethargy (HP:0001254)2.33700384
94Ventricular arrhythmia (HP:0004308)2.32588454
95Exercise intolerance (HP:0003546)2.31206749
96Abnormality of the Achilles tendon (HP:0005109)2.30520630
97Hypercholesterolemia (HP:0003124)2.30289728
98Abnormality of the intrinsic pathway (HP:0010989)2.29271892
99Abnormality of complement system (HP:0005339)2.27502105
100Areflexia of lower limbs (HP:0002522)2.27365953
101Hyperinsulinemic hypoglycemia (HP:0000825)2.27008255
102Myotonia (HP:0002486)2.24655965
103Abnormal atrioventricular conduction (HP:0005150)2.23986419
104Abnormality of purine metabolism (HP:0004352)2.23526764
105Abnormality of nucleobase metabolism (HP:0010932)2.23291341
106Abnormality of pyrimidine metabolism (HP:0004353)2.22820496
107Fat malabsorption (HP:0002630)2.21397511
108Hepatocellular carcinoma (HP:0001402)2.20946171
109Spastic diplegia (HP:0001264)2.18486161
110EMG: neuropathic changes (HP:0003445)2.18106701
111Multiple enchondromatosis (HP:0005701)2.16321992
112Shoulder girdle muscle weakness (HP:0003547)2.14787643
113Lymphangioma (HP:0100764)2.14084466
114Conjunctival hamartoma (HP:0100780)2.10152876
115Mildly elevated creatine phosphokinase (HP:0008180)2.07560737
116Abnormality of the gallbladder (HP:0005264)2.05509105
117Ventricular fibrillation (HP:0001663)2.04693068
118Reticulocytosis (HP:0001923)2.03892049
119Microvesicular hepatic steatosis (HP:0001414)2.02609381
120Difficulty running (HP:0009046)2.01579276
121Dysmetric saccades (HP:0000641)2.00341496
122Lower limb amyotrophy (HP:0007210)2.00121682
123Progressive external ophthalmoplegia (HP:0000590)1.99882290
124Abnormality of the foot musculature (HP:0001436)1.98496208
125Vomiting (HP:0002013)1.97720000
126Muscle stiffness (HP:0003552)1.97365350
127Abnormal mitochondria in muscle tissue (HP:0008316)1.97331470
128Abnormality of the calcaneus (HP:0008364)1.96897681
129Increased intramyocellular lipid droplets (HP:0012240)1.95309210
130Generalized aminoaciduria (HP:0002909)1.92198816
131Hepatic necrosis (HP:0002605)1.92036950
132Increased variability in muscle fiber diameter (HP:0003557)1.91506322
133Hyperuricemia (HP:0002149)1.91050731
134Increased purine levels (HP:0004368)1.91050731
135Ulnar deviation of the wrist (HP:0003049)1.88029172
136Difficulty climbing stairs (HP:0003551)1.85245522
137Scapular winging (HP:0003691)1.82257021
138Pelvic girdle muscle weakness (HP:0003749)1.80908506
139Foot dorsiflexor weakness (HP:0009027)1.80754090
140Generalized muscle weakness (HP:0003324)1.79500704
141Abnormality of the musculature of the pelvis (HP:0001469)1.76153939
142Abnormality of the hip-girdle musculature (HP:0001445)1.76153939
143Cortical dysplasia (HP:0002539)1.75583914
144Acute encephalopathy (HP:0006846)1.72406809
145Lactic acidosis (HP:0003128)1.70906364
146Increased muscle lipid content (HP:0009058)1.69145228
147Frequent falls (HP:0002359)1.68722337
148Achilles tendon contracture (HP:0001771)1.67871899
149Absent phalangeal crease (HP:0006109)1.66704536
150Acute necrotizing encephalopathy (HP:0006965)1.65497858
151Spinal rigidity (HP:0003306)1.65308810
152Decreased activity of mitochondrial respiratory chain (HP:0008972)1.59649095
153Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.59649095
154Reduced antithrombin III activity (HP:0001976)1.59133100
155Increased serum lactate (HP:0002151)1.58260704
156Back pain (HP:0003418)1.57911725
157Abnormality of pain sensation (HP:0010832)1.57537133
158Impaired pain sensation (HP:0007328)1.57537133
159Abnormality of the shoulder girdle musculature (HP:0001435)1.55608569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.78206099
2BCKDK4.61509027
3TRIB34.34724004
4TTN4.17469571
5BUB13.50414813
6NEK13.50151175
7LMTK22.41406220
8PHKG22.40771837
9PHKG12.40771837
10PDK32.29061993
11PDK42.29061993
12OBSCN2.26693095
13CDC72.24421682
14TSSK62.21750152
15TTK2.20825278
16SRPK12.17020725
17SIK12.16409183
18ERN12.12783147
19VRK22.04065091
20FGFR41.88479202
21LIMK11.86657107
22SMG11.75217178
23FLT31.66605724
24PBK1.64838275
25EEF2K1.62749629
26MYLK1.58103349
27MAP2K41.53554729
28RIPK11.50444874
29EIF2AK11.50228102
30PINK11.49046665
31MAP3K71.47407314
32PTK61.40713299
33KSR21.35569469
34DMPK1.35237156
35MAP3K101.32957147
36ARAF1.25466063
37LATS21.24826010
38MAP2K31.22337535
39PAK31.21495869
40PDGFRA1.19539553
41NME21.15431291
42TESK11.14821041
43NME11.09688659
44BRSK11.08827021
45CCNB11.08503204
46MARK11.04394539
47MAPK111.00103866
48PDK20.99262147
49PLK10.98626696
50ICK0.97265491
51CDK120.96671142
52EPHA20.95535507
53AURKA0.92781720
54RET0.92656235
55MAP3K110.92592826
56MAPKAPK30.90966707
57WEE10.90725866
58AURKB0.90223904
59PLK30.89523299
60DAPK20.88370040
61MAP3K50.85355596
62CDK190.85304117
63STK380.85012814
64CHEK20.84692074
65CDK70.82622961
66INSRR0.82589355
67MET0.82584720
68MAPK120.81398916
69LRRK20.79672951
70LATS10.79588612
71PRKD10.79228035
72PAK60.79138534
73PLK40.78878394
74BRAF0.77881043
75KDR0.77750574
76PAK40.77159366
77DAPK10.77151558
78TIE10.76563138
79WNK40.76562656
80PRKAA10.75893107
81CDK11A0.71953371
82ILK0.71478914
83CDK150.69981464
84CDK180.69836413
85CHEK10.69633449
86ATR0.69286753
87PIK3CA0.69057235
88ERBB40.68759306
89CAMKK10.68052349
90CDK140.67678899
91MTOR0.66947091
92CDK80.66823075
93TAOK10.66594985
94DAPK30.66377604
95SCYL20.64009843
96PRKAA20.62921176
97CSNK1G30.62178579
98MAP3K30.60738356
99MAP3K90.58634732
100ALK0.58349612
101TESK20.58057254
102BMX0.57285650
103STK160.56701890
104JAK20.56482180
105CAMK2B0.56432718
106PIK3CG0.56372382
107PDPK10.55131373
108PRKACG0.54869207
109CSNK1A1L0.54184270
110CAMK40.53417553
111MAP3K40.53053217
112AKT20.52900974
113MUSK0.52612753
114TAF10.52204363
115STK40.52071319
116PTK20.52025977
117EIF2AK30.51471891
118ROCK10.51122143
119STK38L0.50959127
120CDK10.50269037
121PRKD30.48395519
122TRIM280.48197795
123NEK90.48070599
124PDK10.47958868
125CAMK2D0.47491208
126CDC42BPA0.46848672
127CDK20.46758398
128CSNK1G10.46600371
129EPHB10.46177690
130CSNK1E0.45604942
131RAF10.44719055
132MAP2K10.44604436
133EPHA40.44130016
134UHMK10.44050632
135BCR0.42546974
136GRK60.42502080
137ABL20.41248494
138MAP3K10.41219716
139FGFR10.41081516
140PAK10.40896447
141PRKCH0.40782326
142STK240.40165646
143NTRK10.40106646
144FER0.39792653
145VRK10.39641247
146NEK20.39098807
147MST1R0.38242904
148ERBB30.37971154
149PTK2B0.37679917
150CAMK2G0.37364566
151KSR10.37297492
152SGK30.37281823
153EIF2AK20.37079983
154PRKACB0.35920059
155ATM0.35595828
156ERBB20.34763173
157CSNK1G20.34522910
158CDK40.34099380
159MAP3K80.32828287
160PRKCZ0.30282229
161MAP2K60.30272441
162MINK10.29332473
163RPS6KB20.29232993

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.53262897
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.48330706
3* Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.47080181
4Fatty acid degradation_Homo sapiens_hsa000713.10286991
5* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.09062337
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.06812739
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.06431683
8* Arginine biosynthesis_Homo sapiens_hsa002202.80654656
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.78742715
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74190991
11Propanoate metabolism_Homo sapiens_hsa006402.72472802
12Tryptophan metabolism_Homo sapiens_hsa003802.52507074
13DNA replication_Homo sapiens_hsa030302.44607742
14Butanoate metabolism_Homo sapiens_hsa006502.44325939
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39997525
16Fatty acid metabolism_Homo sapiens_hsa012122.29757729
17* Carbon metabolism_Homo sapiens_hsa012002.17589749
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.11605643
19Pyruvate metabolism_Homo sapiens_hsa006202.03123871
20Complement and coagulation cascades_Homo sapiens_hsa046101.86974083
21* Biosynthesis of amino acids_Homo sapiens_hsa012301.86778973
22Mismatch repair_Homo sapiens_hsa034301.83423476
23PPAR signaling pathway_Homo sapiens_hsa033201.82846136
24* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71211148
25Peroxisome_Homo sapiens_hsa041461.70864653
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70190336
27Proteasome_Homo sapiens_hsa030501.68254978
28beta-Alanine metabolism_Homo sapiens_hsa004101.64244708
29Base excision repair_Homo sapiens_hsa034101.58787504
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57172246
31Bile secretion_Homo sapiens_hsa049761.48795763
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46931518
33Starch and sucrose metabolism_Homo sapiens_hsa005001.43681839
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35639952
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30778239
36Selenocompound metabolism_Homo sapiens_hsa004501.29876765
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28701758
38* Cysteine and methionine metabolism_Homo sapiens_hsa002701.24898866
39RNA transport_Homo sapiens_hsa030131.24621178
40Spliceosome_Homo sapiens_hsa030401.24042088
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24005983
42Chemical carcinogenesis_Homo sapiens_hsa052041.21768305
43Non-homologous end-joining_Homo sapiens_hsa034501.18975216
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.18910107
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.17796159
46Caffeine metabolism_Homo sapiens_hsa002321.17354188
47Fatty acid elongation_Homo sapiens_hsa000621.16573112
48Cell cycle_Homo sapiens_hsa041101.13593190
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12820630
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11860784
51Histidine metabolism_Homo sapiens_hsa003401.11103653
52Lysine degradation_Homo sapiens_hsa003101.10521501
53Nucleotide excision repair_Homo sapiens_hsa034201.10053752
54Cardiac muscle contraction_Homo sapiens_hsa042601.00426526
55Pyrimidine metabolism_Homo sapiens_hsa002401.00153749
56* Phenylalanine metabolism_Homo sapiens_hsa003600.98812735
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97188524
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.96684540
59* Tyrosine metabolism_Homo sapiens_hsa003500.92357710
60Retinol metabolism_Homo sapiens_hsa008300.92254415
61* Arginine and proline metabolism_Homo sapiens_hsa003300.90630465
62RNA polymerase_Homo sapiens_hsa030200.89699268
63Oocyte meiosis_Homo sapiens_hsa041140.83602517
64mRNA surveillance pathway_Homo sapiens_hsa030150.82680299
65Dilated cardiomyopathy_Homo sapiens_hsa054140.81964385
66Staphylococcus aureus infection_Homo sapiens_hsa051500.81813102
67ABC transporters_Homo sapiens_hsa020100.79980455
68* Fat digestion and absorption_Homo sapiens_hsa049750.75183892
69Sulfur relay system_Homo sapiens_hsa041220.74714729
70Pentose phosphate pathway_Homo sapiens_hsa000300.73867005
71Sulfur metabolism_Homo sapiens_hsa009200.73483888
72Purine metabolism_Homo sapiens_hsa002300.72882077
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72637812
74One carbon pool by folate_Homo sapiens_hsa006700.70652215
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69588180
76Insulin resistance_Homo sapiens_hsa049310.66383713
77Glucagon signaling pathway_Homo sapiens_hsa049220.65875116
78Folate biosynthesis_Homo sapiens_hsa007900.63355718
79Circadian rhythm_Homo sapiens_hsa047100.61044009
80Fructose and mannose metabolism_Homo sapiens_hsa000510.58527126
81Homologous recombination_Homo sapiens_hsa034400.58043847
82Glycerolipid metabolism_Homo sapiens_hsa005610.57481823
83Galactose metabolism_Homo sapiens_hsa000520.56339963
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55479407
85Fatty acid biosynthesis_Homo sapiens_hsa000610.55181539
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.55091963
87Parkinsons disease_Homo sapiens_hsa050120.51903315
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51829511
89Tight junction_Homo sapiens_hsa045300.50002471
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49313554
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.47730505
92RNA degradation_Homo sapiens_hsa030180.44930059
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44033902
94Fanconi anemia pathway_Homo sapiens_hsa034600.43905544
95Insulin signaling pathway_Homo sapiens_hsa049100.43679117
96Glutathione metabolism_Homo sapiens_hsa004800.43410210
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43290687
98Thyroid cancer_Homo sapiens_hsa052160.42355254
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42048076
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41557403
101AMPK signaling pathway_Homo sapiens_hsa041520.41388887
102Ribosome_Homo sapiens_hsa030100.40862998
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38057267
104* Metabolic pathways_Homo sapiens_hsa011000.36407645
105Oxidative phosphorylation_Homo sapiens_hsa001900.34452941
106N-Glycan biosynthesis_Homo sapiens_hsa005100.32447473
107Vibrio cholerae infection_Homo sapiens_hsa051100.31903579
108Synaptic vesicle cycle_Homo sapiens_hsa047210.31451155
109Vitamin B6 metabolism_Homo sapiens_hsa007500.30942635
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29502641
111Basal transcription factors_Homo sapiens_hsa030220.28642905
112Vitamin digestion and absorption_Homo sapiens_hsa049770.28330341
113Prion diseases_Homo sapiens_hsa050200.27628361
114Adherens junction_Homo sapiens_hsa045200.26862208
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.26687536
116Alzheimers disease_Homo sapiens_hsa050100.26323800
117Steroid biosynthesis_Homo sapiens_hsa001000.17615958
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16986994
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15264371
120Type II diabetes mellitus_Homo sapiens_hsa049300.13407287
121mTOR signaling pathway_Homo sapiens_hsa041500.06231187
122Viral myocarditis_Homo sapiens_hsa054160.05768529
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04999668
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.04756108
125HIF-1 signaling pathway_Homo sapiens_hsa040660.02598465
126Huntingtons disease_Homo sapiens_hsa050160.01996476
127Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0588599
128Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0441969
129Bladder cancer_Homo sapiens_hsa05219-0.0422924
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0198924
131cGMP-PKG signaling pathway_Homo sapiens_hsa04022-0.0044756

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »