GOT2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mitotic spindle checkpoint (GO:1903504)4.44986101
2regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.44986101
3cullin deneddylation (GO:0010388)4.23851915
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.23115598
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.23115598
6protein deneddylation (GO:0000338)4.21526315
7positive regulation of mitochondrial fission (GO:0090141)4.03151761
8DNA deamination (GO:0045006)4.01413137
9proteasome assembly (GO:0043248)3.99988141
10protein neddylation (GO:0045116)3.95800549
11kynurenine metabolic process (GO:0070189)3.95081614
12L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.89852972
13DNA double-strand break processing (GO:0000729)3.89206791
14protein-cofactor linkage (GO:0018065)3.85018759
15regulation of cellular amino acid metabolic process (GO:0006521)3.82099514
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81403156
17somatic hypermutation of immunoglobulin genes (GO:0016446)3.71687525
18somatic diversification of immune receptors via somatic mutation (GO:0002566)3.71687525
19aspartate family amino acid catabolic process (GO:0009068)3.71522186
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.58288521
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50352420
22rRNA modification (GO:0000154)3.39757005
23negative regulation of ligase activity (GO:0051352)3.38736839
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38736839
25DNA damage response, detection of DNA damage (GO:0042769)3.36207245
26amino acid salvage (GO:0043102)3.35708159
27L-methionine salvage (GO:0071267)3.35708159
28L-methionine biosynthetic process (GO:0071265)3.35708159
29iron-sulfur cluster assembly (GO:0016226)3.35357665
30metallo-sulfur cluster assembly (GO:0031163)3.35357665
31chromatin remodeling at centromere (GO:0031055)3.35224937
32branched-chain amino acid catabolic process (GO:0009083)3.32822339
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31215523
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29551399
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29551399
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29551399
37aspartate family amino acid biosynthetic process (GO:0009067)3.28439288
38regulation of helicase activity (GO:0051095)3.26364889
39histone H2A acetylation (GO:0043968)3.25758820
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24849011
41signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23192846
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23192846
43CENP-A containing nucleosome assembly (GO:0034080)3.22891059
44ubiquinone metabolic process (GO:0006743)3.22846534
45DNA replication-dependent nucleosome assembly (GO:0006335)3.18826911
46DNA replication-dependent nucleosome organization (GO:0034723)3.18826911
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.16477544
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.14389368
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.14389368
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.14248391
51platelet dense granule organization (GO:0060155)3.14127318
52sequestering of actin monomers (GO:0042989)3.13730842
53spliceosomal snRNP assembly (GO:0000387)3.13401178
54tRNA methylation (GO:0030488)3.12486404
55maturation of 5.8S rRNA (GO:0000460)3.09112959
56establishment of integrated proviral latency (GO:0075713)3.06290277
57ubiquinone biosynthetic process (GO:0006744)3.03090941
58establishment of viral latency (GO:0019043)3.02511416
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02363447
60tRNA modification (GO:0006400)3.01089031
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00305200
62preassembly of GPI anchor in ER membrane (GO:0016254)2.94779649
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94491417
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89371770
65base-excision repair, AP site formation (GO:0006285)2.89103613
66oxidative phosphorylation (GO:0006119)2.88110259
67rRNA methylation (GO:0031167)2.87989506
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.86329162
69organelle disassembly (GO:1903008)2.84611492
70positive regulation of ligase activity (GO:0051351)2.84488271
71de novo protein folding (GO:0006458)2.82775952
72inositol phosphate catabolic process (GO:0071545)2.81342120
73DNA strand elongation involved in DNA replication (GO:0006271)2.81275503
74water-soluble vitamin biosynthetic process (GO:0042364)2.80988336
75L-fucose catabolic process (GO:0042355)2.79364262
76fucose catabolic process (GO:0019317)2.79364262
77L-fucose metabolic process (GO:0042354)2.79364262
78somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.79060365
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.79060365
80isotype switching (GO:0045190)2.79060365
81regulation of sarcomere organization (GO:0060297)2.78708827
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78528262
83tRNA metabolic process (GO:0006399)2.78250385
84de novo posttranslational protein folding (GO:0051084)2.77583048
85tRNA processing (GO:0008033)2.76498141
86dicarboxylic acid catabolic process (GO:0043649)2.75537766
87ATP synthesis coupled proton transport (GO:0015986)2.74666722
88energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74666722
89oxaloacetate metabolic process (GO:0006107)2.74076900
90inositol phosphate dephosphorylation (GO:0046855)2.73191044
91phosphorylated carbohydrate dephosphorylation (GO:0046838)2.73191044
92purine nucleobase biosynthetic process (GO:0009113)2.72377211
93GPI anchor metabolic process (GO:0006505)2.71796451
94regulation of cellular amine metabolic process (GO:0033238)2.71486609
95microtubule depolymerization (GO:0007019)2.71026969
96DNA ligation (GO:0006266)2.70773327
97deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69686162
98tRNA aminoacylation for protein translation (GO:0006418)2.69147293
99cholesterol biosynthetic process (GO:0006695)2.69066277
100histone exchange (GO:0043486)2.68267335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.24080707
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.26180048
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.04310114
4E2F7_22180533_ChIP-Seq_HELA_Human3.84496492
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.57985260
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.44947902
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24819315
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06262137
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92665424
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.87981198
11IGF1R_20145208_ChIP-Seq_DFB_Human2.86819748
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80492737
13VDR_23849224_ChIP-Seq_CD4+_Human2.72484680
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71040120
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69869671
16FOXP3_21729870_ChIP-Seq_TREG_Human2.54340008
17ELK1_19687146_ChIP-ChIP_HELA_Human2.50562422
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45337013
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.44079857
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34443355
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26724617
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.26232156
23ZNF274_21170338_ChIP-Seq_K562_Hela2.20046635
24GABP_19822575_ChIP-Seq_HepG2_Human2.10239106
25VDR_22108803_ChIP-Seq_LS180_Human2.07952147
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04147435
27DCP1A_22483619_ChIP-Seq_HELA_Human2.01295849
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97876300
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96575429
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94307693
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93036221
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88398794
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.88260169
34MYC_18940864_ChIP-ChIP_HL60_Human1.82732509
35IRF1_19129219_ChIP-ChIP_H3396_Human1.82597678
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80508608
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80151688
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78884098
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75279793
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.73757740
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68088829
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66012060
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61220900
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59492944
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59069577
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58247433
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57674825
48EWS_26573619_Chip-Seq_HEK293_Human1.50352945
49TTF2_22483619_ChIP-Seq_HELA_Human1.45880289
50XRN2_22483619_ChIP-Seq_HELA_Human1.44317201
51FUS_26573619_Chip-Seq_HEK293_Human1.43724569
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40169127
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37010658
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36540960
55CIITA_25753668_ChIP-Seq_RAJI_Human1.34351517
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34219633
57TAF15_26573619_Chip-Seq_HEK293_Human1.29773996
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25131422
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23723872
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18388722
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.18346167
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13277455
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11095032
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09455533
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07558753
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07486329
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06851735
68TP53_22573176_ChIP-Seq_HFKS_Human1.06746282
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05930731
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03574439
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03273740
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.01813904
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00984771
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96909803
75E2F1_21310950_ChIP-Seq_MCF-7_Human0.95908898
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92119233
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91636436
78ELK1_22589737_ChIP-Seq_MCF10A_Human0.91319257
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91217911
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90391059
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89601271
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89075229
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88280668
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88039848
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87984130
86PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87451465
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86253827
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.86233435
89ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85913167
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85673997
91KDM5A_27292631_Chip-Seq_BREAST_Human0.84305262
92P300_19829295_ChIP-Seq_ESCs_Human0.84302057
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84125756
94NANOG_18555785_ChIP-Seq_MESCs_Mouse0.83971973
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83406094
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83234450
97CBP_20019798_ChIP-Seq_JUKART_Human0.83234450
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.83189893
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83189893
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82605816

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.52305875
2MP0006072_abnormal_retinal_apoptosis3.32680729
3MP0003693_abnormal_embryo_hatching3.27628684
4MP0001529_abnormal_vocalization3.08655800
5MP0010094_abnormal_chromosome_stability2.99735371
6MP0008058_abnormal_DNA_repair2.98796456
7MP0001984_abnormal_olfaction2.91885245
8MP0008877_abnormal_DNA_methylation2.90947250
9MP0008789_abnormal_olfactory_epithelium2.68670232
10MP0005645_abnormal_hypothalamus_physiol2.65922239
11MP0004147_increased_porphyrin_level2.51131566
12MP0005084_abnormal_gallbladder_morpholo2.49265289
13MP0003786_premature_aging2.44530493
14MP0005394_taste/olfaction_phenotype2.41315263
15MP0005499_abnormal_olfactory_system2.41315263
16MP0008932_abnormal_embryonic_tissue2.17198184
17MP0003121_genomic_imprinting2.15753680
18MP0006035_abnormal_mitochondrial_morpho2.09353694
19MP0003122_maternal_imprinting2.07704362
20MP0003221_abnormal_cardiomyocyte_apopto1.99478961
21MP0003806_abnormal_nucleotide_metabolis1.94467575
22MP0006276_abnormal_autonomic_nervous1.85724693
23MP0003787_abnormal_imprinting1.82050897
24MP0008995_early_reproductive_senescence1.76141536
25MP0005671_abnormal_response_to1.73315586
26MP0005253_abnormal_eye_physiology1.73137818
27MP0008007_abnormal_cellular_replicative1.70248973
28MP0004133_heterotaxia1.65361306
29MP0005551_abnormal_eye_electrophysiolog1.64018687
30MP0001188_hyperpigmentation1.62441758
31MP0003880_abnormal_central_pattern1.59842831
32MP0003111_abnormal_nucleus_morphology1.56292965
33MP0002254_reproductive_system_inflammat1.51756637
34MP0005646_abnormal_pituitary_gland1.47312180
35MP0002822_catalepsy1.45631888
36MP0002751_abnormal_autonomic_nervous1.44283703
37MP0004957_abnormal_blastocyst_morpholog1.42427048
38MP0008875_abnormal_xenobiotic_pharmacok1.42283629
39MP0004782_abnormal_surfactant_physiolog1.41084972
40MP0002736_abnormal_nociception_after1.37075878
41MP0006036_abnormal_mitochondrial_physio1.35039481
42MP0008872_abnormal_physiological_respon1.32284895
43MP0003718_maternal_effect1.31366364
44MP0000372_irregular_coat_pigmentation1.26478862
45MP0005075_abnormal_melanosome_morpholog1.24673195
46MP0001968_abnormal_touch/_nociception1.24276579
47MP0006292_abnormal_olfactory_placode1.22096111
48MP0009046_muscle_twitch1.18171485
49MP0002837_dystrophic_cardiac_calcinosis1.13255663
50MP0009697_abnormal_copulation1.11964111
51MP0001501_abnormal_sleep_pattern1.11928974
52MP0002272_abnormal_nervous_system1.05937035
53MP0002234_abnormal_pharynx_morphology1.05680608
54MP0000358_abnormal_cell_content/1.04050634
55MP0003567_abnormal_fetal_cardiomyocyte1.04012551
56MP0001727_abnormal_embryo_implantation1.02778077
57MP0003724_increased_susceptibility_to1.01280806
58MP0001270_distended_abdomen1.01082528
59MP0001661_extended_life_span1.01036666
60MP0001764_abnormal_homeostasis0.98938334
61MP0003077_abnormal_cell_cycle0.98792106
62MP0004215_abnormal_myocardial_fiber0.94098666
63MP0003011_delayed_dark_adaptation0.91762022
64MP0003646_muscle_fatigue0.90735295
65MP0003890_abnormal_embryonic-extraembry0.89680251
66MP0002090_abnormal_vision0.89470067
67MP0001502_abnormal_circadian_rhythm0.87092579
68MP0001293_anophthalmia0.83510466
69MP0001929_abnormal_gametogenesis0.80633636
70MP0005386_behavior/neurological_phenoty0.78312688
71MP0004924_abnormal_behavior0.78312688
72MP0001986_abnormal_taste_sensitivity0.76984098
73MP0001905_abnormal_dopamine_level0.76292804
74MP0005220_abnormal_exocrine_pancreas0.76128290
75MP0000647_abnormal_sebaceous_gland0.75819419
76MP0005332_abnormal_amino_acid0.74285281
77MP0002938_white_spotting0.73769918
78MP0005410_abnormal_fertilization0.73537146
79MP0001177_atelectasis0.71359552
80MP0005377_hearing/vestibular/ear_phenot0.68770775
81MP0003878_abnormal_ear_physiology0.68770775
82MP0005391_vision/eye_phenotype0.68286358
83MP0003698_abnormal_male_reproductive0.67008567
84MP0002638_abnormal_pupillary_reflex0.66716881
85MP0003137_abnormal_impulse_conducting0.63743729
86MP0000653_abnormal_sex_gland0.62365737
87MP0002184_abnormal_innervation0.61723813
88MP0002210_abnormal_sex_determination0.60880679
89MP0002752_abnormal_somatic_nervous0.60546671
90MP0008775_abnormal_heart_ventricle0.60388478
91MP0000631_abnormal_neuroendocrine_gland0.60340815
92MP0001119_abnormal_female_reproductive0.58491836
93MP0005389_reproductive_system_phenotype0.57764505
94MP0002069_abnormal_eating/drinking_beha0.57323411
95MP0001730_embryonic_growth_arrest0.56987016
96MP0001919_abnormal_reproductive_system0.56885733
97MP0005195_abnormal_posterior_eye0.56770286
98MP0000049_abnormal_middle_ear0.56592747
99MP0003195_calcinosis0.56493534
100MP0000313_abnormal_cell_death0.56188271

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.72406042
2Abnormality of glycolysis (HP:0004366)3.65295691
3Increased serum pyruvate (HP:0003542)3.61851873
4Abnormal mitochondria in muscle tissue (HP:0008316)3.55169305
5Mitochondrial inheritance (HP:0001427)3.45777832
6Increased CSF lactate (HP:0002490)3.43525040
7Acute encephalopathy (HP:0006846)3.40674553
8Hepatocellular necrosis (HP:0001404)3.17315393
93-Methylglutaconic aciduria (HP:0003535)3.10906806
10Increased serum lactate (HP:0002151)3.07791300
11Progressive macrocephaly (HP:0004481)3.06824295
12Nephrogenic diabetes insipidus (HP:0009806)2.91811646
13Medial flaring of the eyebrow (HP:0010747)2.89905360
14Increased hepatocellular lipid droplets (HP:0006565)2.86512625
15Hepatic necrosis (HP:0002605)2.85068041
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82263515
17Abnormality of alanine metabolism (HP:0010916)2.82263515
18Hyperalaninemia (HP:0003348)2.82263515
19Methylmalonic acidemia (HP:0002912)2.80823394
20Lipid accumulation in hepatocytes (HP:0006561)2.77590091
21Cerebral edema (HP:0002181)2.77329438
22Lactic acidosis (HP:0003128)2.74408812
23Retinal dysplasia (HP:0007973)2.71447098
24Polyphagia (HP:0002591)2.70950062
25Failure to thrive in infancy (HP:0001531)2.68743448
26Congenital primary aphakia (HP:0007707)2.66444639
27Gait imbalance (HP:0002141)2.62852619
28Renal cortical cysts (HP:0000803)2.62215240
29Methylmalonic aciduria (HP:0012120)2.58019781
30Abolished electroretinogram (ERG) (HP:0000550)2.55464526
31Cortical dysplasia (HP:0002539)2.54978983
32IgG deficiency (HP:0004315)2.53495045
33Increased intramyocellular lipid droplets (HP:0012240)2.49585419
34Abnormality of the labia minora (HP:0012880)2.43716827
35Opisthotonus (HP:0002179)2.42892614
36Congenital stationary night blindness (HP:0007642)2.42396450
37Lissencephaly (HP:0001339)2.30386430
38Aplastic anemia (HP:0001915)2.28052188
39Molar tooth sign on MRI (HP:0002419)2.26455376
40Abnormality of midbrain morphology (HP:0002418)2.26455376
41Hypothermia (HP:0002045)2.26056697
42Abnormal protein glycosylation (HP:0012346)2.20929838
43Abnormal glycosylation (HP:0012345)2.20929838
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20929838
45Abnormal protein N-linked glycosylation (HP:0012347)2.20929838
46Posterior subcapsular cataract (HP:0007787)2.18978251
47Colon cancer (HP:0003003)2.16419118
48Lethargy (HP:0001254)2.16316121
49Nephronophthisis (HP:0000090)2.13625681
50True hermaphroditism (HP:0010459)2.13003691
51Abnormality of methionine metabolism (HP:0010901)2.12552875
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12142684
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12142684
54Renal Fanconi syndrome (HP:0001994)2.11947528
55Cerebral hypomyelination (HP:0006808)2.11232771
56Central scotoma (HP:0000603)2.10979662
57Increased muscle lipid content (HP:0009058)2.08817005
58Respiratory failure (HP:0002878)2.08477544
59Abnormality of serum amino acid levels (HP:0003112)2.07526218
60Pancreatic cysts (HP:0001737)2.07487936
61Optic disc pallor (HP:0000543)2.06952205
62Atrophy/Degeneration involving motor neurons (HP:0007373)2.06622717
63Pancreatic fibrosis (HP:0100732)2.05204574
64Broad foot (HP:0001769)2.02931746
65Emotional lability (HP:0000712)2.02623308
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00479265
67Exercise intolerance (HP:0003546)1.99342866
68Vaginal atresia (HP:0000148)1.99039835
69IgM deficiency (HP:0002850)1.98543117
70Progressive microcephaly (HP:0000253)1.97053073
71Type I transferrin isoform profile (HP:0003642)1.96004302
72Abnormality of the renal cortex (HP:0011035)1.93420499
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92657042
74Abnormality of the anterior horn cell (HP:0006802)1.92127165
75Degeneration of anterior horn cells (HP:0002398)1.92127165
76Poor suck (HP:0002033)1.91679530
77Inability to walk (HP:0002540)1.91246795
78Genital tract atresia (HP:0001827)1.90829150
79Attenuation of retinal blood vessels (HP:0007843)1.89134615
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85760874
81Hyperglycinemia (HP:0002154)1.84024838
82Amyotrophic lateral sclerosis (HP:0007354)1.82920090
83Abnormality of glycine metabolism (HP:0010895)1.82687311
84Abnormality of serine family amino acid metabolism (HP:0010894)1.82687311
85Severe combined immunodeficiency (HP:0004430)1.80274326
86Pancytopenia (HP:0001876)1.78567611
87Abnormal gallbladder physiology (HP:0012438)1.78344746
88Cholecystitis (HP:0001082)1.78344746
89CNS demyelination (HP:0007305)1.77280138
90Muscular hypotonia of the trunk (HP:0008936)1.77178286
91Small hand (HP:0200055)1.76404791
92Hyperammonemia (HP:0001987)1.76349518
93Ependymoma (HP:0002888)1.76218620
94Neoplasm of the peripheral nervous system (HP:0100007)1.76035463
95Decreased testicular size (HP:0008734)1.75449738
96Abnormality of the prostate (HP:0008775)1.74227460
97Volvulus (HP:0002580)1.72095082
98Abnormality of the renal medulla (HP:0100957)1.71546322
99Abnormality of the pons (HP:0007361)1.70447715
100Neoplasm of the adrenal gland (HP:0100631)1.70158502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.47156915
2BCR3.29435175
3TRIM283.23471995
4BCKDK2.79402330
5BUB12.68457339
6TESK22.61101896
7SRPK12.54514244
8ZAK2.47274388
9TSSK62.38636444
10VRK22.37122702
11WNK32.18527241
12EIF2AK32.12502485
13CSNK1G31.99808296
14TAOK31.91559062
15NEK11.83686732
16CSNK1A1L1.82091359
17ERBB31.76686420
18VRK11.74789684
19CSNK1G21.71583845
20CSNK1G11.64967577
21PLK31.61615359
22KDR1.59071048
23WNK41.56846029
24PLK41.56426635
25SIK31.52914636
26RPS6KA41.42116948
27TLK11.38232795
28LIMK11.31718557
29NUAK11.30876049
30CDC71.28892760
31TTK1.28438087
32MKNK11.23836376
33TXK1.23142771
34MST41.22404323
35MATK1.21903655
36MAP2K71.18781595
37GRK11.12814148
38TESK11.09606620
39PAK61.06438864
40OXSR11.05583665
41STK161.04845776
42MAPK131.04051250
43CDK191.02712499
44DAPK10.97308994
45ADRBK20.96977659
46INSRR0.95706581
47EIF2AK20.93879491
48PLK20.93672908
49MKNK20.92955689
50PLK10.92924233
51GRK60.88197752
52ATR0.82343926
53CASK0.80490782
54DYRK20.80317294
55BRSK20.78512805
56STK390.76721943
57EPHA30.75131269
58MARK10.73092886
59FRK0.71367347
60TIE10.70144362
61MAP3K40.69117265
62UHMK10.67742424
63MAP3K50.63713873
64RPS6KA50.62967263
65STK38L0.62550522
66AURKB0.60690609
67TAF10.58852931
68BRSK10.57824067
69BMPR1B0.56849938
70CAMKK20.56821285
71AURKA0.56340097
72CDK140.52949240
73MAP2K20.52795020
74KIT0.50088546
75PRKCE0.47957813
76TEC0.47192359
77CSNK2A10.44272993
78ATM0.43700512
79CHEK20.43138227
80EPHA40.42929857
81MINK10.42659012
82NME10.42052076
83FLT30.41396454
84MAP3K140.40505716
85CDK180.40301561
86CCNB10.39045069
87DYRK30.38939523
88CAMK2B0.35489168
89PAK30.34894057
90CDK70.34295486
91ITK0.33971230
92ADRBK10.33590777
93CSNK1A10.32565554
94MAP2K60.32050551
95PRKCQ0.31901700
96CSNK1D0.31886762
97CDK150.29135185
98MUSK0.28824475
99ACVR1B0.28331277
100CLK10.27634455

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.37989502
2Proteasome_Homo sapiens_hsa030504.17425454
3Protein export_Homo sapiens_hsa030602.62686013
4DNA replication_Homo sapiens_hsa030302.45837625
5Non-homologous end-joining_Homo sapiens_hsa034502.40256662
6Base excision repair_Homo sapiens_hsa034102.33187824
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21120227
8Mismatch repair_Homo sapiens_hsa034302.19314005
9Oxidative phosphorylation_Homo sapiens_hsa001902.15591369
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03230194
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02840329
12Parkinsons disease_Homo sapiens_hsa050122.02391324
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98549572
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95752146
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93821303
16RNA polymerase_Homo sapiens_hsa030201.84643164
17Spliceosome_Homo sapiens_hsa030401.83596073
18Fatty acid elongation_Homo sapiens_hsa000621.78731233
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72375497
20Steroid biosynthesis_Homo sapiens_hsa001001.68375925
21Homologous recombination_Homo sapiens_hsa034401.53221151
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51915713
23One carbon pool by folate_Homo sapiens_hsa006701.50846832
24Basal transcription factors_Homo sapiens_hsa030221.49402914
25Propanoate metabolism_Homo sapiens_hsa006401.48621861
26Nucleotide excision repair_Homo sapiens_hsa034201.47312933
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.45722501
28Phenylalanine metabolism_Homo sapiens_hsa003601.44518501
29RNA transport_Homo sapiens_hsa030131.38396752
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36557362
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36536196
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35666299
33Pyrimidine metabolism_Homo sapiens_hsa002401.32030493
34Biosynthesis of amino acids_Homo sapiens_hsa012301.28506507
35Pyruvate metabolism_Homo sapiens_hsa006201.28019023
36Huntingtons disease_Homo sapiens_hsa050161.26872403
37RNA degradation_Homo sapiens_hsa030181.26334536
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24658411
39Fanconi anemia pathway_Homo sapiens_hsa034601.23497640
40Butanoate metabolism_Homo sapiens_hsa006501.20696586
41Carbon metabolism_Homo sapiens_hsa012001.16477732
42Primary immunodeficiency_Homo sapiens_hsa053401.13668454
43Alzheimers disease_Homo sapiens_hsa050101.05077368
44Purine metabolism_Homo sapiens_hsa002301.04819684
45Phototransduction_Homo sapiens_hsa047441.00760765
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93498207
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92259886
48Caffeine metabolism_Homo sapiens_hsa002320.92000123
49Tryptophan metabolism_Homo sapiens_hsa003800.91256078
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90574385
51Peroxisome_Homo sapiens_hsa041460.79732592
52Tyrosine metabolism_Homo sapiens_hsa003500.79556489
53Cell cycle_Homo sapiens_hsa041100.77346585
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75782888
55Arginine biosynthesis_Homo sapiens_hsa002200.75367892
56Arginine and proline metabolism_Homo sapiens_hsa003300.70658916
57Fatty acid metabolism_Homo sapiens_hsa012120.70471355
58Collecting duct acid secretion_Homo sapiens_hsa049660.67311277
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.66619530
60Metabolic pathways_Homo sapiens_hsa011000.66110105
61Antigen processing and presentation_Homo sapiens_hsa046120.62594092
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60971953
63Circadian rhythm_Homo sapiens_hsa047100.60631865
64Vitamin B6 metabolism_Homo sapiens_hsa007500.60228056
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59579307
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58844647
67Regulation of autophagy_Homo sapiens_hsa041400.57747614
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57304461
69Fatty acid degradation_Homo sapiens_hsa000710.57295349
70Sulfur metabolism_Homo sapiens_hsa009200.56519499
71Systemic lupus erythematosus_Homo sapiens_hsa053220.54371530
72Type I diabetes mellitus_Homo sapiens_hsa049400.54135020
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53097969
74Fat digestion and absorption_Homo sapiens_hsa049750.51664068
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51081811
76Oocyte meiosis_Homo sapiens_hsa041140.50235717
77Nitrogen metabolism_Homo sapiens_hsa009100.48442774
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48100003
79beta-Alanine metabolism_Homo sapiens_hsa004100.46743007
80Graft-versus-host disease_Homo sapiens_hsa053320.46366455
81Rheumatoid arthritis_Homo sapiens_hsa053230.44106522
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43500434
83mRNA surveillance pathway_Homo sapiens_hsa030150.39985200
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39412141
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39396814
86Nicotine addiction_Homo sapiens_hsa050330.37756915
87Folate biosynthesis_Homo sapiens_hsa007900.37746824
88Glutathione metabolism_Homo sapiens_hsa004800.37180851
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.35581497
90Alcoholism_Homo sapiens_hsa050340.35333987
91Selenocompound metabolism_Homo sapiens_hsa004500.34019570
92N-Glycan biosynthesis_Homo sapiens_hsa005100.32890169
93Asthma_Homo sapiens_hsa053100.32377404
94p53 signaling pathway_Homo sapiens_hsa041150.31887535
95Allograft rejection_Homo sapiens_hsa053300.31032045
96Epstein-Barr virus infection_Homo sapiens_hsa051690.30653038
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.30470128
98Shigellosis_Homo sapiens_hsa051310.29816360
99Herpes simplex infection_Homo sapiens_hsa051680.29780242
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29561946

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »