

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of mitotic spindle checkpoint (GO:1903504) | 4.44986101 |
| 2 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 4.44986101 |
| 3 | cullin deneddylation (GO:0010388) | 4.23851915 |
| 4 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.23115598 |
| 5 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.23115598 |
| 6 | protein deneddylation (GO:0000338) | 4.21526315 |
| 7 | positive regulation of mitochondrial fission (GO:0090141) | 4.03151761 |
| 8 | DNA deamination (GO:0045006) | 4.01413137 |
| 9 | proteasome assembly (GO:0043248) | 3.99988141 |
| 10 | protein neddylation (GO:0045116) | 3.95800549 |
| 11 | kynurenine metabolic process (GO:0070189) | 3.95081614 |
| 12 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.89852972 |
| 13 | DNA double-strand break processing (GO:0000729) | 3.89206791 |
| 14 | protein-cofactor linkage (GO:0018065) | 3.85018759 |
| 15 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.82099514 |
| 16 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.81403156 |
| 17 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.71687525 |
| 18 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.71687525 |
| 19 | aspartate family amino acid catabolic process (GO:0009068) | 3.71522186 |
| 20 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.58288521 |
| 21 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.50352420 |
| 22 | rRNA modification (GO:0000154) | 3.39757005 |
| 23 | negative regulation of ligase activity (GO:0051352) | 3.38736839 |
| 24 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.38736839 |
| 25 | DNA damage response, detection of DNA damage (GO:0042769) | 3.36207245 |
| 26 | amino acid salvage (GO:0043102) | 3.35708159 |
| 27 | L-methionine salvage (GO:0071267) | 3.35708159 |
| 28 | L-methionine biosynthetic process (GO:0071265) | 3.35708159 |
| 29 | iron-sulfur cluster assembly (GO:0016226) | 3.35357665 |
| 30 | metallo-sulfur cluster assembly (GO:0031163) | 3.35357665 |
| 31 | chromatin remodeling at centromere (GO:0031055) | 3.35224937 |
| 32 | branched-chain amino acid catabolic process (GO:0009083) | 3.32822339 |
| 33 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.31215523 |
| 34 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.29551399 |
| 35 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.29551399 |
| 36 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.29551399 |
| 37 | aspartate family amino acid biosynthetic process (GO:0009067) | 3.28439288 |
| 38 | regulation of helicase activity (GO:0051095) | 3.26364889 |
| 39 | histone H2A acetylation (GO:0043968) | 3.25758820 |
| 40 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.24849011 |
| 41 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.23192846 |
| 42 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.23192846 |
| 43 | CENP-A containing nucleosome assembly (GO:0034080) | 3.22891059 |
| 44 | ubiquinone metabolic process (GO:0006743) | 3.22846534 |
| 45 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.18826911 |
| 46 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.18826911 |
| 47 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.16477544 |
| 48 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.14389368 |
| 49 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.14389368 |
| 50 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.14248391 |
| 51 | platelet dense granule organization (GO:0060155) | 3.14127318 |
| 52 | sequestering of actin monomers (GO:0042989) | 3.13730842 |
| 53 | spliceosomal snRNP assembly (GO:0000387) | 3.13401178 |
| 54 | tRNA methylation (GO:0030488) | 3.12486404 |
| 55 | maturation of 5.8S rRNA (GO:0000460) | 3.09112959 |
| 56 | establishment of integrated proviral latency (GO:0075713) | 3.06290277 |
| 57 | ubiquinone biosynthetic process (GO:0006744) | 3.03090941 |
| 58 | establishment of viral latency (GO:0019043) | 3.02511416 |
| 59 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.02363447 |
| 60 | tRNA modification (GO:0006400) | 3.01089031 |
| 61 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.00305200 |
| 62 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.94779649 |
| 63 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.94491417 |
| 64 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.89371770 |
| 65 | base-excision repair, AP site formation (GO:0006285) | 2.89103613 |
| 66 | oxidative phosphorylation (GO:0006119) | 2.88110259 |
| 67 | rRNA methylation (GO:0031167) | 2.87989506 |
| 68 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.86329162 |
| 69 | organelle disassembly (GO:1903008) | 2.84611492 |
| 70 | positive regulation of ligase activity (GO:0051351) | 2.84488271 |
| 71 | de novo protein folding (GO:0006458) | 2.82775952 |
| 72 | inositol phosphate catabolic process (GO:0071545) | 2.81342120 |
| 73 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.81275503 |
| 74 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.80988336 |
| 75 | L-fucose catabolic process (GO:0042355) | 2.79364262 |
| 76 | fucose catabolic process (GO:0019317) | 2.79364262 |
| 77 | L-fucose metabolic process (GO:0042354) | 2.79364262 |
| 78 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.79060365 |
| 79 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.79060365 |
| 80 | isotype switching (GO:0045190) | 2.79060365 |
| 81 | regulation of sarcomere organization (GO:0060297) | 2.78708827 |
| 82 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.78528262 |
| 83 | tRNA metabolic process (GO:0006399) | 2.78250385 |
| 84 | de novo posttranslational protein folding (GO:0051084) | 2.77583048 |
| 85 | tRNA processing (GO:0008033) | 2.76498141 |
| 86 | dicarboxylic acid catabolic process (GO:0043649) | 2.75537766 |
| 87 | ATP synthesis coupled proton transport (GO:0015986) | 2.74666722 |
| 88 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.74666722 |
| 89 | oxaloacetate metabolic process (GO:0006107) | 2.74076900 |
| 90 | inositol phosphate dephosphorylation (GO:0046855) | 2.73191044 |
| 91 | phosphorylated carbohydrate dephosphorylation (GO:0046838) | 2.73191044 |
| 92 | purine nucleobase biosynthetic process (GO:0009113) | 2.72377211 |
| 93 | GPI anchor metabolic process (GO:0006505) | 2.71796451 |
| 94 | regulation of cellular amine metabolic process (GO:0033238) | 2.71486609 |
| 95 | microtubule depolymerization (GO:0007019) | 2.71026969 |
| 96 | DNA ligation (GO:0006266) | 2.70773327 |
| 97 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.69686162 |
| 98 | tRNA aminoacylation for protein translation (GO:0006418) | 2.69147293 |
| 99 | cholesterol biosynthetic process (GO:0006695) | 2.69066277 |
| 100 | histone exchange (GO:0043486) | 2.68267335 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.24080707 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.26180048 |
| 3 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.04310114 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.84496492 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.57985260 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.44947902 |
| 7 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.24819315 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.06262137 |
| 9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.92665424 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.87981198 |
| 11 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.86819748 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.80492737 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.72484680 |
| 14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.71040120 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.69869671 |
| 16 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.54340008 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.50562422 |
| 18 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.45337013 |
| 19 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.44079857 |
| 20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.34443355 |
| 21 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.26724617 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.26232156 |
| 23 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.20046635 |
| 24 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.10239106 |
| 25 | VDR_22108803_ChIP-Seq_LS180_Human | 2.07952147 |
| 26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.04147435 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.01295849 |
| 28 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.97876300 |
| 29 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.96575429 |
| 30 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.94307693 |
| 31 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.93036221 |
| 32 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.88398794 |
| 33 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.88260169 |
| 34 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.82732509 |
| 35 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.82597678 |
| 36 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.80508608 |
| 37 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.80151688 |
| 38 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78884098 |
| 39 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.75279793 |
| 40 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.73757740 |
| 41 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.68088829 |
| 42 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.66012060 |
| 43 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.61220900 |
| 44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.59492944 |
| 45 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.59069577 |
| 46 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.58247433 |
| 47 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.57674825 |
| 48 | EWS_26573619_Chip-Seq_HEK293_Human | 1.50352945 |
| 49 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.45880289 |
| 50 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.44317201 |
| 51 | FUS_26573619_Chip-Seq_HEK293_Human | 1.43724569 |
| 52 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.40169127 |
| 53 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.37010658 |
| 54 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.36540960 |
| 55 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.34351517 |
| 56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.34219633 |
| 57 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.29773996 |
| 58 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.25131422 |
| 59 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.23723872 |
| 60 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.18388722 |
| 61 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.18346167 |
| 62 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.13277455 |
| 63 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.11095032 |
| 64 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.09455533 |
| 65 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.07558753 |
| 66 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.07486329 |
| 67 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.06851735 |
| 68 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.06746282 |
| 69 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.05930731 |
| 70 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.03574439 |
| 71 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.03273740 |
| 72 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.01813904 |
| 73 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.00984771 |
| 74 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.96909803 |
| 75 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.95908898 |
| 76 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.92119233 |
| 77 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.91636436 |
| 78 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.91319257 |
| 79 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.91217911 |
| 80 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.90391059 |
| 81 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.89601271 |
| 82 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.89075229 |
| 83 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.88280668 |
| 84 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.88039848 |
| 85 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.87984130 |
| 86 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.87451465 |
| 87 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.86253827 |
| 88 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.86233435 |
| 89 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.85913167 |
| 90 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.85673997 |
| 91 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.84305262 |
| 92 | P300_19829295_ChIP-Seq_ESCs_Human | 0.84302057 |
| 93 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84125756 |
| 94 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.83971973 |
| 95 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.83406094 |
| 96 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.83234450 |
| 97 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.83234450 |
| 98 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.83189893 |
| 99 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.83189893 |
| 100 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.82605816 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002102_abnormal_ear_morphology | 3.52305875 |
| 2 | MP0006072_abnormal_retinal_apoptosis | 3.32680729 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.27628684 |
| 4 | MP0001529_abnormal_vocalization | 3.08655800 |
| 5 | MP0010094_abnormal_chromosome_stability | 2.99735371 |
| 6 | MP0008058_abnormal_DNA_repair | 2.98796456 |
| 7 | MP0001984_abnormal_olfaction | 2.91885245 |
| 8 | MP0008877_abnormal_DNA_methylation | 2.90947250 |
| 9 | MP0008789_abnormal_olfactory_epithelium | 2.68670232 |
| 10 | MP0005645_abnormal_hypothalamus_physiol | 2.65922239 |
| 11 | MP0004147_increased_porphyrin_level | 2.51131566 |
| 12 | MP0005084_abnormal_gallbladder_morpholo | 2.49265289 |
| 13 | MP0003786_premature_aging | 2.44530493 |
| 14 | MP0005394_taste/olfaction_phenotype | 2.41315263 |
| 15 | MP0005499_abnormal_olfactory_system | 2.41315263 |
| 16 | MP0008932_abnormal_embryonic_tissue | 2.17198184 |
| 17 | MP0003121_genomic_imprinting | 2.15753680 |
| 18 | MP0006035_abnormal_mitochondrial_morpho | 2.09353694 |
| 19 | MP0003122_maternal_imprinting | 2.07704362 |
| 20 | MP0003221_abnormal_cardiomyocyte_apopto | 1.99478961 |
| 21 | MP0003806_abnormal_nucleotide_metabolis | 1.94467575 |
| 22 | MP0006276_abnormal_autonomic_nervous | 1.85724693 |
| 23 | MP0003787_abnormal_imprinting | 1.82050897 |
| 24 | MP0008995_early_reproductive_senescence | 1.76141536 |
| 25 | MP0005671_abnormal_response_to | 1.73315586 |
| 26 | MP0005253_abnormal_eye_physiology | 1.73137818 |
| 27 | MP0008007_abnormal_cellular_replicative | 1.70248973 |
| 28 | MP0004133_heterotaxia | 1.65361306 |
| 29 | MP0005551_abnormal_eye_electrophysiolog | 1.64018687 |
| 30 | MP0001188_hyperpigmentation | 1.62441758 |
| 31 | MP0003880_abnormal_central_pattern | 1.59842831 |
| 32 | MP0003111_abnormal_nucleus_morphology | 1.56292965 |
| 33 | MP0002254_reproductive_system_inflammat | 1.51756637 |
| 34 | MP0005646_abnormal_pituitary_gland | 1.47312180 |
| 35 | MP0002822_catalepsy | 1.45631888 |
| 36 | MP0002751_abnormal_autonomic_nervous | 1.44283703 |
| 37 | MP0004957_abnormal_blastocyst_morpholog | 1.42427048 |
| 38 | MP0008875_abnormal_xenobiotic_pharmacok | 1.42283629 |
| 39 | MP0004782_abnormal_surfactant_physiolog | 1.41084972 |
| 40 | MP0002736_abnormal_nociception_after | 1.37075878 |
| 41 | MP0006036_abnormal_mitochondrial_physio | 1.35039481 |
| 42 | MP0008872_abnormal_physiological_respon | 1.32284895 |
| 43 | MP0003718_maternal_effect | 1.31366364 |
| 44 | MP0000372_irregular_coat_pigmentation | 1.26478862 |
| 45 | MP0005075_abnormal_melanosome_morpholog | 1.24673195 |
| 46 | MP0001968_abnormal_touch/_nociception | 1.24276579 |
| 47 | MP0006292_abnormal_olfactory_placode | 1.22096111 |
| 48 | MP0009046_muscle_twitch | 1.18171485 |
| 49 | MP0002837_dystrophic_cardiac_calcinosis | 1.13255663 |
| 50 | MP0009697_abnormal_copulation | 1.11964111 |
| 51 | MP0001501_abnormal_sleep_pattern | 1.11928974 |
| 52 | MP0002272_abnormal_nervous_system | 1.05937035 |
| 53 | MP0002234_abnormal_pharynx_morphology | 1.05680608 |
| 54 | MP0000358_abnormal_cell_content/ | 1.04050634 |
| 55 | MP0003567_abnormal_fetal_cardiomyocyte | 1.04012551 |
| 56 | MP0001727_abnormal_embryo_implantation | 1.02778077 |
| 57 | MP0003724_increased_susceptibility_to | 1.01280806 |
| 58 | MP0001270_distended_abdomen | 1.01082528 |
| 59 | MP0001661_extended_life_span | 1.01036666 |
| 60 | MP0001764_abnormal_homeostasis | 0.98938334 |
| 61 | MP0003077_abnormal_cell_cycle | 0.98792106 |
| 62 | MP0004215_abnormal_myocardial_fiber | 0.94098666 |
| 63 | MP0003011_delayed_dark_adaptation | 0.91762022 |
| 64 | MP0003646_muscle_fatigue | 0.90735295 |
| 65 | MP0003890_abnormal_embryonic-extraembry | 0.89680251 |
| 66 | MP0002090_abnormal_vision | 0.89470067 |
| 67 | MP0001502_abnormal_circadian_rhythm | 0.87092579 |
| 68 | MP0001293_anophthalmia | 0.83510466 |
| 69 | MP0001929_abnormal_gametogenesis | 0.80633636 |
| 70 | MP0005386_behavior/neurological_phenoty | 0.78312688 |
| 71 | MP0004924_abnormal_behavior | 0.78312688 |
| 72 | MP0001986_abnormal_taste_sensitivity | 0.76984098 |
| 73 | MP0001905_abnormal_dopamine_level | 0.76292804 |
| 74 | MP0005220_abnormal_exocrine_pancreas | 0.76128290 |
| 75 | MP0000647_abnormal_sebaceous_gland | 0.75819419 |
| 76 | MP0005332_abnormal_amino_acid | 0.74285281 |
| 77 | MP0002938_white_spotting | 0.73769918 |
| 78 | MP0005410_abnormal_fertilization | 0.73537146 |
| 79 | MP0001177_atelectasis | 0.71359552 |
| 80 | MP0005377_hearing/vestibular/ear_phenot | 0.68770775 |
| 81 | MP0003878_abnormal_ear_physiology | 0.68770775 |
| 82 | MP0005391_vision/eye_phenotype | 0.68286358 |
| 83 | MP0003698_abnormal_male_reproductive | 0.67008567 |
| 84 | MP0002638_abnormal_pupillary_reflex | 0.66716881 |
| 85 | MP0003137_abnormal_impulse_conducting | 0.63743729 |
| 86 | MP0000653_abnormal_sex_gland | 0.62365737 |
| 87 | MP0002184_abnormal_innervation | 0.61723813 |
| 88 | MP0002210_abnormal_sex_determination | 0.60880679 |
| 89 | MP0002752_abnormal_somatic_nervous | 0.60546671 |
| 90 | MP0008775_abnormal_heart_ventricle | 0.60388478 |
| 91 | MP0000631_abnormal_neuroendocrine_gland | 0.60340815 |
| 92 | MP0001119_abnormal_female_reproductive | 0.58491836 |
| 93 | MP0005389_reproductive_system_phenotype | 0.57764505 |
| 94 | MP0002069_abnormal_eating/drinking_beha | 0.57323411 |
| 95 | MP0001730_embryonic_growth_arrest | 0.56987016 |
| 96 | MP0001919_abnormal_reproductive_system | 0.56885733 |
| 97 | MP0005195_abnormal_posterior_eye | 0.56770286 |
| 98 | MP0000049_abnormal_middle_ear | 0.56592747 |
| 99 | MP0003195_calcinosis | 0.56493534 |
| 100 | MP0000313_abnormal_cell_death | 0.56188271 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.72406042 |
| 2 | Abnormality of glycolysis (HP:0004366) | 3.65295691 |
| 3 | Increased serum pyruvate (HP:0003542) | 3.61851873 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.55169305 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.45777832 |
| 6 | Increased CSF lactate (HP:0002490) | 3.43525040 |
| 7 | Acute encephalopathy (HP:0006846) | 3.40674553 |
| 8 | Hepatocellular necrosis (HP:0001404) | 3.17315393 |
| 9 | 3-Methylglutaconic aciduria (HP:0003535) | 3.10906806 |
| 10 | Increased serum lactate (HP:0002151) | 3.07791300 |
| 11 | Progressive macrocephaly (HP:0004481) | 3.06824295 |
| 12 | Nephrogenic diabetes insipidus (HP:0009806) | 2.91811646 |
| 13 | Medial flaring of the eyebrow (HP:0010747) | 2.89905360 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 2.86512625 |
| 15 | Hepatic necrosis (HP:0002605) | 2.85068041 |
| 16 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.82263515 |
| 17 | Abnormality of alanine metabolism (HP:0010916) | 2.82263515 |
| 18 | Hyperalaninemia (HP:0003348) | 2.82263515 |
| 19 | Methylmalonic acidemia (HP:0002912) | 2.80823394 |
| 20 | Lipid accumulation in hepatocytes (HP:0006561) | 2.77590091 |
| 21 | Cerebral edema (HP:0002181) | 2.77329438 |
| 22 | Lactic acidosis (HP:0003128) | 2.74408812 |
| 23 | Retinal dysplasia (HP:0007973) | 2.71447098 |
| 24 | Polyphagia (HP:0002591) | 2.70950062 |
| 25 | Failure to thrive in infancy (HP:0001531) | 2.68743448 |
| 26 | Congenital primary aphakia (HP:0007707) | 2.66444639 |
| 27 | Gait imbalance (HP:0002141) | 2.62852619 |
| 28 | Renal cortical cysts (HP:0000803) | 2.62215240 |
| 29 | Methylmalonic aciduria (HP:0012120) | 2.58019781 |
| 30 | Abolished electroretinogram (ERG) (HP:0000550) | 2.55464526 |
| 31 | Cortical dysplasia (HP:0002539) | 2.54978983 |
| 32 | IgG deficiency (HP:0004315) | 2.53495045 |
| 33 | Increased intramyocellular lipid droplets (HP:0012240) | 2.49585419 |
| 34 | Abnormality of the labia minora (HP:0012880) | 2.43716827 |
| 35 | Opisthotonus (HP:0002179) | 2.42892614 |
| 36 | Congenital stationary night blindness (HP:0007642) | 2.42396450 |
| 37 | Lissencephaly (HP:0001339) | 2.30386430 |
| 38 | Aplastic anemia (HP:0001915) | 2.28052188 |
| 39 | Molar tooth sign on MRI (HP:0002419) | 2.26455376 |
| 40 | Abnormality of midbrain morphology (HP:0002418) | 2.26455376 |
| 41 | Hypothermia (HP:0002045) | 2.26056697 |
| 42 | Abnormal protein glycosylation (HP:0012346) | 2.20929838 |
| 43 | Abnormal glycosylation (HP:0012345) | 2.20929838 |
| 44 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.20929838 |
| 45 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.20929838 |
| 46 | Posterior subcapsular cataract (HP:0007787) | 2.18978251 |
| 47 | Colon cancer (HP:0003003) | 2.16419118 |
| 48 | Lethargy (HP:0001254) | 2.16316121 |
| 49 | Nephronophthisis (HP:0000090) | 2.13625681 |
| 50 | True hermaphroditism (HP:0010459) | 2.13003691 |
| 51 | Abnormality of methionine metabolism (HP:0010901) | 2.12552875 |
| 52 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.12142684 |
| 53 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.12142684 |
| 54 | Renal Fanconi syndrome (HP:0001994) | 2.11947528 |
| 55 | Cerebral hypomyelination (HP:0006808) | 2.11232771 |
| 56 | Central scotoma (HP:0000603) | 2.10979662 |
| 57 | Increased muscle lipid content (HP:0009058) | 2.08817005 |
| 58 | Respiratory failure (HP:0002878) | 2.08477544 |
| 59 | Abnormality of serum amino acid levels (HP:0003112) | 2.07526218 |
| 60 | Pancreatic cysts (HP:0001737) | 2.07487936 |
| 61 | Optic disc pallor (HP:0000543) | 2.06952205 |
| 62 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.06622717 |
| 63 | Pancreatic fibrosis (HP:0100732) | 2.05204574 |
| 64 | Broad foot (HP:0001769) | 2.02931746 |
| 65 | Emotional lability (HP:0000712) | 2.02623308 |
| 66 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.00479265 |
| 67 | Exercise intolerance (HP:0003546) | 1.99342866 |
| 68 | Vaginal atresia (HP:0000148) | 1.99039835 |
| 69 | IgM deficiency (HP:0002850) | 1.98543117 |
| 70 | Progressive microcephaly (HP:0000253) | 1.97053073 |
| 71 | Type I transferrin isoform profile (HP:0003642) | 1.96004302 |
| 72 | Abnormality of the renal cortex (HP:0011035) | 1.93420499 |
| 73 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.92657042 |
| 74 | Abnormality of the anterior horn cell (HP:0006802) | 1.92127165 |
| 75 | Degeneration of anterior horn cells (HP:0002398) | 1.92127165 |
| 76 | Poor suck (HP:0002033) | 1.91679530 |
| 77 | Inability to walk (HP:0002540) | 1.91246795 |
| 78 | Genital tract atresia (HP:0001827) | 1.90829150 |
| 79 | Attenuation of retinal blood vessels (HP:0007843) | 1.89134615 |
| 80 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.85760874 |
| 81 | Hyperglycinemia (HP:0002154) | 1.84024838 |
| 82 | Amyotrophic lateral sclerosis (HP:0007354) | 1.82920090 |
| 83 | Abnormality of glycine metabolism (HP:0010895) | 1.82687311 |
| 84 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.82687311 |
| 85 | Severe combined immunodeficiency (HP:0004430) | 1.80274326 |
| 86 | Pancytopenia (HP:0001876) | 1.78567611 |
| 87 | Abnormal gallbladder physiology (HP:0012438) | 1.78344746 |
| 88 | Cholecystitis (HP:0001082) | 1.78344746 |
| 89 | CNS demyelination (HP:0007305) | 1.77280138 |
| 90 | Muscular hypotonia of the trunk (HP:0008936) | 1.77178286 |
| 91 | Small hand (HP:0200055) | 1.76404791 |
| 92 | Hyperammonemia (HP:0001987) | 1.76349518 |
| 93 | Ependymoma (HP:0002888) | 1.76218620 |
| 94 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.76035463 |
| 95 | Decreased testicular size (HP:0008734) | 1.75449738 |
| 96 | Abnormality of the prostate (HP:0008775) | 1.74227460 |
| 97 | Volvulus (HP:0002580) | 1.72095082 |
| 98 | Abnormality of the renal medulla (HP:0100957) | 1.71546322 |
| 99 | Abnormality of the pons (HP:0007361) | 1.70447715 |
| 100 | Neoplasm of the adrenal gland (HP:0100631) | 1.70158502 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K2 | 4.47156915 |
| 2 | BCR | 3.29435175 |
| 3 | TRIM28 | 3.23471995 |
| 4 | BCKDK | 2.79402330 |
| 5 | BUB1 | 2.68457339 |
| 6 | TESK2 | 2.61101896 |
| 7 | SRPK1 | 2.54514244 |
| 8 | ZAK | 2.47274388 |
| 9 | TSSK6 | 2.38636444 |
| 10 | VRK2 | 2.37122702 |
| 11 | WNK3 | 2.18527241 |
| 12 | EIF2AK3 | 2.12502485 |
| 13 | CSNK1G3 | 1.99808296 |
| 14 | TAOK3 | 1.91559062 |
| 15 | NEK1 | 1.83686732 |
| 16 | CSNK1A1L | 1.82091359 |
| 17 | ERBB3 | 1.76686420 |
| 18 | VRK1 | 1.74789684 |
| 19 | CSNK1G2 | 1.71583845 |
| 20 | CSNK1G1 | 1.64967577 |
| 21 | PLK3 | 1.61615359 |
| 22 | KDR | 1.59071048 |
| 23 | WNK4 | 1.56846029 |
| 24 | PLK4 | 1.56426635 |
| 25 | SIK3 | 1.52914636 |
| 26 | RPS6KA4 | 1.42116948 |
| 27 | TLK1 | 1.38232795 |
| 28 | LIMK1 | 1.31718557 |
| 29 | NUAK1 | 1.30876049 |
| 30 | CDC7 | 1.28892760 |
| 31 | TTK | 1.28438087 |
| 32 | MKNK1 | 1.23836376 |
| 33 | TXK | 1.23142771 |
| 34 | MST4 | 1.22404323 |
| 35 | MATK | 1.21903655 |
| 36 | MAP2K7 | 1.18781595 |
| 37 | GRK1 | 1.12814148 |
| 38 | TESK1 | 1.09606620 |
| 39 | PAK6 | 1.06438864 |
| 40 | OXSR1 | 1.05583665 |
| 41 | STK16 | 1.04845776 |
| 42 | MAPK13 | 1.04051250 |
| 43 | CDK19 | 1.02712499 |
| 44 | DAPK1 | 0.97308994 |
| 45 | ADRBK2 | 0.96977659 |
| 46 | INSRR | 0.95706581 |
| 47 | EIF2AK2 | 0.93879491 |
| 48 | PLK2 | 0.93672908 |
| 49 | MKNK2 | 0.92955689 |
| 50 | PLK1 | 0.92924233 |
| 51 | GRK6 | 0.88197752 |
| 52 | ATR | 0.82343926 |
| 53 | CASK | 0.80490782 |
| 54 | DYRK2 | 0.80317294 |
| 55 | BRSK2 | 0.78512805 |
| 56 | STK39 | 0.76721943 |
| 57 | EPHA3 | 0.75131269 |
| 58 | MARK1 | 0.73092886 |
| 59 | FRK | 0.71367347 |
| 60 | TIE1 | 0.70144362 |
| 61 | MAP3K4 | 0.69117265 |
| 62 | UHMK1 | 0.67742424 |
| 63 | MAP3K5 | 0.63713873 |
| 64 | RPS6KA5 | 0.62967263 |
| 65 | STK38L | 0.62550522 |
| 66 | AURKB | 0.60690609 |
| 67 | TAF1 | 0.58852931 |
| 68 | BRSK1 | 0.57824067 |
| 69 | BMPR1B | 0.56849938 |
| 70 | CAMKK2 | 0.56821285 |
| 71 | AURKA | 0.56340097 |
| 72 | CDK14 | 0.52949240 |
| 73 | MAP2K2 | 0.52795020 |
| 74 | KIT | 0.50088546 |
| 75 | PRKCE | 0.47957813 |
| 76 | TEC | 0.47192359 |
| 77 | CSNK2A1 | 0.44272993 |
| 78 | ATM | 0.43700512 |
| 79 | CHEK2 | 0.43138227 |
| 80 | EPHA4 | 0.42929857 |
| 81 | MINK1 | 0.42659012 |
| 82 | NME1 | 0.42052076 |
| 83 | FLT3 | 0.41396454 |
| 84 | MAP3K14 | 0.40505716 |
| 85 | CDK18 | 0.40301561 |
| 86 | CCNB1 | 0.39045069 |
| 87 | DYRK3 | 0.38939523 |
| 88 | CAMK2B | 0.35489168 |
| 89 | PAK3 | 0.34894057 |
| 90 | CDK7 | 0.34295486 |
| 91 | ITK | 0.33971230 |
| 92 | ADRBK1 | 0.33590777 |
| 93 | CSNK1A1 | 0.32565554 |
| 94 | MAP2K6 | 0.32050551 |
| 95 | PRKCQ | 0.31901700 |
| 96 | CSNK1D | 0.31886762 |
| 97 | CDK15 | 0.29135185 |
| 98 | MUSK | 0.28824475 |
| 99 | ACVR1B | 0.28331277 |
| 100 | CLK1 | 0.27634455 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 5.37989502 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.17425454 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.62686013 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 2.45837625 |
| 5 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.40256662 |
| 6 | Base excision repair_Homo sapiens_hsa03410 | 2.33187824 |
| 7 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.21120227 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.19314005 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.15591369 |
| 10 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.03230194 |
| 11 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.02840329 |
| 12 | Parkinsons disease_Homo sapiens_hsa05012 | 2.02391324 |
| 13 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.98549572 |
| 14 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.95752146 |
| 15 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.93821303 |
| 16 | RNA polymerase_Homo sapiens_hsa03020 | 1.84643164 |
| 17 | Spliceosome_Homo sapiens_hsa03040 | 1.83596073 |
| 18 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.78731233 |
| 19 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.72375497 |
| 20 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.68375925 |
| 21 | Homologous recombination_Homo sapiens_hsa03440 | 1.53221151 |
| 22 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.51915713 |
| 23 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.50846832 |
| 24 | Basal transcription factors_Homo sapiens_hsa03022 | 1.49402914 |
| 25 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.48621861 |
| 26 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.47312933 |
| 27 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.45722501 |
| 28 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.44518501 |
| 29 | RNA transport_Homo sapiens_hsa03013 | 1.38396752 |
| 30 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.36557362 |
| 31 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.36536196 |
| 32 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.35666299 |
| 33 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.32030493 |
| 34 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.28506507 |
| 35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.28019023 |
| 36 | Huntingtons disease_Homo sapiens_hsa05016 | 1.26872403 |
| 37 | RNA degradation_Homo sapiens_hsa03018 | 1.26334536 |
| 38 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.24658411 |
| 39 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.23497640 |
| 40 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.20696586 |
| 41 | Carbon metabolism_Homo sapiens_hsa01200 | 1.16477732 |
| 42 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.13668454 |
| 43 | Alzheimers disease_Homo sapiens_hsa05010 | 1.05077368 |
| 44 | Purine metabolism_Homo sapiens_hsa00230 | 1.04819684 |
| 45 | Phototransduction_Homo sapiens_hsa04744 | 1.00760765 |
| 46 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.93498207 |
| 47 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.92259886 |
| 48 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.92000123 |
| 49 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.91256078 |
| 50 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.90574385 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.79732592 |
| 52 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.79556489 |
| 53 | Cell cycle_Homo sapiens_hsa04110 | 0.77346585 |
| 54 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.75782888 |
| 55 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.75367892 |
| 56 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.70658916 |
| 57 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.70471355 |
| 58 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.67311277 |
| 59 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.66619530 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.66110105 |
| 61 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.62594092 |
| 62 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.60971953 |
| 63 | Circadian rhythm_Homo sapiens_hsa04710 | 0.60631865 |
| 64 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.60228056 |
| 65 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.59579307 |
| 66 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.58844647 |
| 67 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.57747614 |
| 68 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.57304461 |
| 69 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.57295349 |
| 70 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.56519499 |
| 71 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.54371530 |
| 72 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.54135020 |
| 73 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.53097969 |
| 74 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.51664068 |
| 75 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.51081811 |
| 76 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.50235717 |
| 77 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.48442774 |
| 78 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.48100003 |
| 79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.46743007 |
| 80 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.46366455 |
| 81 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.44106522 |
| 82 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.43500434 |
| 83 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.39985200 |
| 84 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.39412141 |
| 85 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.39396814 |
| 86 | Nicotine addiction_Homo sapiens_hsa05033 | 0.37756915 |
| 87 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.37746824 |
| 88 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.37180851 |
| 89 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.35581497 |
| 90 | Alcoholism_Homo sapiens_hsa05034 | 0.35333987 |
| 91 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.34019570 |
| 92 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.32890169 |
| 93 | Asthma_Homo sapiens_hsa05310 | 0.32377404 |
| 94 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.31887535 |
| 95 | Allograft rejection_Homo sapiens_hsa05330 | 0.31032045 |
| 96 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.30653038 |
| 97 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.30470128 |
| 98 | Shigellosis_Homo sapiens_hsa05131 | 0.29816360 |
| 99 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.29780242 |
| 100 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.29561946 |

