GOT2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)5.16989405
2regulation of activation of Janus kinase activity (GO:0010533)4.85324963
3negative regulation of cell killing (GO:0031342)4.74889209
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.74889209
5DNA deamination (GO:0045006)4.68906394
6positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.54598675
7protein polyglutamylation (GO:0018095)4.29927478
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.21509397
9regulation of mitotic spindle checkpoint (GO:1903504)4.21509397
10negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.20590910
11protein-cofactor linkage (GO:0018065)4.12734468
12base-excision repair, AP site formation (GO:0006285)4.11637409
13regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.08842251
14kynurenine metabolic process (GO:0070189)4.03489180
15positive regulation of defense response to virus by host (GO:0002230)3.96612595
16S-adenosylmethionine metabolic process (GO:0046500)3.83965170
17negative regulation of DNA-templated transcription, elongation (GO:0032785)3.77737320
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.70251635
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.70251635
20isotype switching (GO:0045190)3.59612008
21somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.59612008
22somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.59612008
23protein deneddylation (GO:0000338)3.55415108
24iron-sulfur cluster assembly (GO:0016226)3.48772073
25metallo-sulfur cluster assembly (GO:0031163)3.48772073
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.46273572
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.44745294
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.44745294
29rRNA catabolic process (GO:0016075)3.42027452
30positive regulation of T-helper 1 type immune response (GO:0002827)3.37528941
31ubiquinone metabolic process (GO:0006743)3.35817054
32positive regulation of interleukin-17 production (GO:0032740)3.35599728
33cellular response to nicotine (GO:0071316)3.33417045
34ubiquinone biosynthetic process (GO:0006744)3.30771883
35aspartate family amino acid biosynthetic process (GO:0009067)3.29569479
36negative regulation of interleukin-10 production (GO:0032693)3.29371195
37RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21882587
38retinal cone cell development (GO:0046549)3.21627577
39positive regulation of prostaglandin secretion (GO:0032308)3.20645435
40DNA damage response, detection of DNA damage (GO:0042769)3.18482192
41positive regulation of osteoclast differentiation (GO:0045672)3.13337793
42deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.12639393
43amino acid salvage (GO:0043102)3.12217869
44L-methionine salvage (GO:0071267)3.12217869
45L-methionine biosynthetic process (GO:0071265)3.12217869
46fucose catabolic process (GO:0019317)3.11974701
47L-fucose metabolic process (GO:0042354)3.11974701
48L-fucose catabolic process (GO:0042355)3.11974701
49preassembly of GPI anchor in ER membrane (GO:0016254)3.09338064
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07342275
51purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.06877072
52branched-chain amino acid catabolic process (GO:0009083)3.06793187
53positive regulation of cell fate commitment (GO:0010455)3.04589250
54somatic diversification of immunoglobulins (GO:0016445)3.04300554
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02806406
56negative regulation of neurological system process (GO:0031645)3.00731773
57sleep (GO:0030431)2.96490084
58mitochondrial respiratory chain complex assembly (GO:0033108)2.96019721
59protein complex biogenesis (GO:0070271)2.94643603
60regulation of germinal center formation (GO:0002634)2.93967029
61dicarboxylic acid catabolic process (GO:0043649)2.93586783
62positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.91292152
63purine deoxyribonucleotide metabolic process (GO:0009151)2.90881781
64somatic recombination of immunoglobulin gene segments (GO:0016447)2.89601243
65regulation of defense response to virus by host (GO:0050691)2.88785762
66aspartate family amino acid catabolic process (GO:0009068)2.87395989
67deoxyribose phosphate metabolic process (GO:0019692)2.84066259
68protein localization to cilium (GO:0061512)2.82970348
69ADP metabolic process (GO:0046031)2.82368426
70regulation of cellular amino acid metabolic process (GO:0006521)2.81399653
71positive regulation of T cell mediated cytotoxicity (GO:0001916)2.80780762
722-deoxyribonucleotide metabolic process (GO:0009394)2.80345434
73positive regulation of mitochondrial fission (GO:0090141)2.79847729
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.79053102
75regulation of T-helper 1 type immune response (GO:0002825)2.78720279
76cullin deneddylation (GO:0010388)2.77482810
77regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.77409377
78histone H2A ubiquitination (GO:0033522)2.77247623
79negative regulation of T cell apoptotic process (GO:0070233)2.77108547
80deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.76885031
81regulation of cilium movement (GO:0003352)2.72856356
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.72814837
83cellular response to interleukin-15 (GO:0071350)2.71817115
84positive regulation of oligodendrocyte differentiation (GO:0048714)2.71439145
85mitochondrial RNA metabolic process (GO:0000959)2.68513765
86pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67377622
87positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.65356215
88postreplication repair (GO:0006301)2.64550273
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.63192055
90termination of RNA polymerase III transcription (GO:0006386)2.63192055
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62839965
92adenosine metabolic process (GO:0046085)2.62410803
93regulation of translational termination (GO:0006449)2.61040051
94protein K6-linked ubiquitination (GO:0085020)2.60555365
95histone H2A monoubiquitination (GO:0035518)2.60520707
96methionine biosynthetic process (GO:0009086)2.59752914
97regulation of T cell mediated cytotoxicity (GO:0001914)2.58404446
98retinal rod cell development (GO:0046548)2.57573384
99molting cycle (GO:0042303)2.56675985
100hair cycle (GO:0042633)2.56675985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.52841978
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.96108473
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.93248827
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.74171487
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.48876594
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.42316913
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00508640
8ZNF274_21170338_ChIP-Seq_K562_Hela2.95727173
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.78504821
10VDR_23849224_ChIP-Seq_CD4+_Human2.76598055
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66479632
12IGF1R_20145208_ChIP-Seq_DFB_Human2.56939102
13FOXP3_21729870_ChIP-Seq_TREG_Human2.54980399
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50615271
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.48800879
16IRF1_19129219_ChIP-ChIP_H3396_Human2.42017505
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21970277
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19199064
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19192330
20ELK1_19687146_ChIP-ChIP_HELA_Human2.18758155
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16338425
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10964909
23MYC_18940864_ChIP-ChIP_HL60_Human2.02317294
24E2F7_22180533_ChIP-Seq_HELA_Human2.00882394
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96754088
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.95149157
27CIITA_25753668_ChIP-Seq_RAJI_Human1.87811949
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87393368
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85402874
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.84935004
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77699549
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77157232
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76763009
34GABP_19822575_ChIP-Seq_HepG2_Human1.75688198
35VDR_22108803_ChIP-Seq_LS180_Human1.68658311
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68053024
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66519300
38DCP1A_22483619_ChIP-Seq_HELA_Human1.63789692
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53491841
40TP53_22573176_ChIP-Seq_HFKS_Human1.51000371
41GATA3_26560356_Chip-Seq_TH2_Human1.48879254
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.48585751
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46700149
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46633302
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.44667008
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42560753
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.40167780
48RUNX_20019798_ChIP-Seq_JUKART_Human1.39976624
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35219132
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34781305
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33177545
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32712126
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31495010
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29664013
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29521128
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29217681
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28883966
58TTF2_22483619_ChIP-Seq_HELA_Human1.27701234
59MYB_26560356_Chip-Seq_TH2_Human1.25479292
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25335033
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23119422
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22377682
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20476612
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18840918
65TAF15_26573619_Chip-Seq_HEK293_Human1.16510835
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.12940310
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09688999
68EWS_26573619_Chip-Seq_HEK293_Human1.08575553
69FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08208501
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07845946
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06941146
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05906531
73XRN2_22483619_ChIP-Seq_HELA_Human1.05738864
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03854413
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03819803
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96383511
77CBP_20019798_ChIP-Seq_JUKART_Human0.96383511
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95638312
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94892995
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94544438
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93720612
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93133059
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92598102
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.92598102
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92542658
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90351824
87GATA3_26560356_Chip-Seq_TH1_Human0.87264675
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87165013
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86746026
90GATA3_27048872_Chip-Seq_THYMUS_Human0.86399878
91MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85469824
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85356211
93HOXB7_26014856_ChIP-Seq_BT474_Human0.85241829
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84754466
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84515695
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84216925
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83924046
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81080351
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.78410396
100NANOG_19829295_ChIP-Seq_ESCs_Human0.78192344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.04534967
2MP0008877_abnormal_DNA_methylation3.99449507
3MP0005075_abnormal_melanosome_morpholog3.90429135
4MP0005671_abnormal_response_to3.40556842
5MP0006072_abnormal_retinal_apoptosis3.29532529
6MP0003787_abnormal_imprinting3.11832874
7MP0001529_abnormal_vocalization2.79698906
8MP0003786_premature_aging2.30608405
9MP0003724_increased_susceptibility_to2.30362017
10MP0005645_abnormal_hypothalamus_physiol2.20745172
11MP0010094_abnormal_chromosome_stability2.13387798
12MP0003763_abnormal_thymus_physiology2.12905428
13MP0008058_abnormal_DNA_repair2.07103413
14MP0005646_abnormal_pituitary_gland1.90150188
15MP0003646_muscle_fatigue1.84564336
16MP0003693_abnormal_embryo_hatching1.80732163
17MP0005084_abnormal_gallbladder_morpholo1.80556128
18MP0003195_calcinosis1.80395949
19MP0005000_abnormal_immune_tolerance1.76880528
20MP0005377_hearing/vestibular/ear_phenot1.72964874
21MP0003878_abnormal_ear_physiology1.72964874
22MP0005253_abnormal_eye_physiology1.64235791
23MP0008872_abnormal_physiological_respon1.62601428
24MP0001984_abnormal_olfaction1.62503579
25MP0008789_abnormal_olfactory_epithelium1.57949058
26MP0006276_abnormal_autonomic_nervous1.54509373
27MP0001835_abnormal_antigen_presentation1.49008689
28MP0001919_abnormal_reproductive_system1.42110877
29MP0002166_altered_tumor_susceptibility1.39939067
30MP0002638_abnormal_pupillary_reflex1.38234944
31MP0005551_abnormal_eye_electrophysiolog1.36145896
32MP0003121_genomic_imprinting1.34946727
33MP0001188_hyperpigmentation1.34207386
34MP0002234_abnormal_pharynx_morphology1.32515307
35MP0002254_reproductive_system_inflammat1.30196594
36MP0001968_abnormal_touch/_nociception1.28858697
37MP0002736_abnormal_nociception_after1.28848394
38MP0002723_abnormal_immune_serum1.27502175
39MP0002822_catalepsy1.27453665
40MP0002163_abnormal_gland_morphology1.26232827
41MP0001501_abnormal_sleep_pattern1.25003040
42MP0005499_abnormal_olfactory_system1.24433715
43MP0005394_taste/olfaction_phenotype1.24433715
44MP0008875_abnormal_xenobiotic_pharmacok1.16503247
45MP0002148_abnormal_hypersensitivity_rea1.16476359
46MP0001764_abnormal_homeostasis1.15437417
47MP0001800_abnormal_humoral_immune1.15202929
48MP0003111_abnormal_nucleus_morphology1.15165506
49MP0006035_abnormal_mitochondrial_morpho1.14135996
50MP0002272_abnormal_nervous_system1.13397396
51MP0003436_decreased_susceptibility_to1.10594408
52MP0001819_abnormal_immune_cell1.09681715
53MP0000372_irregular_coat_pigmentation1.07657514
54MP0002006_tumorigenesis1.06423607
55MP0002420_abnormal_adaptive_immunity1.05533679
56MP0000689_abnormal_spleen_morphology1.03136635
57MP0005310_abnormal_salivary_gland1.01745086
58MP0004147_increased_porphyrin_level1.01582333
59MP0008775_abnormal_heart_ventricle1.01492246
60MP0002722_abnormal_immune_system1.00980767
61MP0009333_abnormal_splenocyte_physiolog1.00687703
62MP0008995_early_reproductive_senescence0.97563698
63MP0008932_abnormal_embryonic_tissue0.97162670
64MP0004924_abnormal_behavior0.95878185
65MP0005386_behavior/neurological_phenoty0.95878185
66MP0004885_abnormal_endolymph0.95502643
67MP0002398_abnormal_bone_marrow0.94198962
68MP0002452_abnormal_antigen_presenting0.94087572
69MP0003866_abnormal_defecation0.93529756
70MP0002751_abnormal_autonomic_nervous0.93130709
71MP0000703_abnormal_thymus_morphology0.90652211
72MP0002876_abnormal_thyroid_physiology0.90455289
73MP0003638_abnormal_response/metabolism_0.89691407
74MP0009785_altered_susceptibility_to0.89615753
75MP0000716_abnormal_immune_system0.88737150
76MP0009046_muscle_twitch0.88204413
77MP0004215_abnormal_myocardial_fiber0.88157965
78MP0005389_reproductive_system_phenotype0.87917924
79MP0002933_joint_inflammation0.87838311
80MP0004142_abnormal_muscle_tone0.84253086
81MP0006036_abnormal_mitochondrial_physio0.83971241
82MP0002009_preneoplasia0.83800390
83MP0005647_abnormal_sex_gland0.83198854
84MP0009764_decreased_sensitivity_to0.81961885
85MP0005387_immune_system_phenotype0.80947083
86MP0001790_abnormal_immune_system0.80947083
87MP0010368_abnormal_lymphatic_system0.80362085
88MP0003045_fibrosis0.79365455
89MP0001661_extended_life_span0.79058852
90MP0000685_abnormal_immune_system0.78943883
91MP0000647_abnormal_sebaceous_gland0.78927866
92MP0003806_abnormal_nucleotide_metabolis0.78075988
93MP0003122_maternal_imprinting0.77927940
94MP0005025_abnormal_response_to0.75613400
95MP0000465_gastrointestinal_hemorrhage0.74410128
96MP0008007_abnormal_cellular_replicative0.73942166
97MP0003011_delayed_dark_adaptation0.70281437
98MP0003567_abnormal_fetal_cardiomyocyte0.69957916
99MP0002405_respiratory_system_inflammati0.69366962
100MP0001845_abnormal_inflammatory_respons0.67496064

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.15396809
2Retrobulbar optic neuritis (HP:0100654)3.73575086
3Optic neuritis (HP:0100653)3.73575086
4Visual hallucinations (HP:0002367)3.71004010
5Adactyly (HP:0009776)3.62767914
6Renal cortical cysts (HP:0000803)3.62485573
7Amyotrophic lateral sclerosis (HP:0007354)3.56035750
8Abnormal mitochondria in muscle tissue (HP:0008316)3.40926891
9Mitochondrial inheritance (HP:0001427)3.33885144
10Hepatocellular necrosis (HP:0001404)3.29555850
11Increased CSF lactate (HP:0002490)3.24478617
12Acute necrotizing encephalopathy (HP:0006965)3.14438918
13Myositis (HP:0100614)3.08981195
14Increased intramyocellular lipid droplets (HP:0012240)3.04707082
15Attenuation of retinal blood vessels (HP:0007843)2.98146223
16Orchitis (HP:0100796)2.91378377
17Keratoconjunctivitis (HP:0001096)2.91131492
18Increased muscle lipid content (HP:0009058)2.90242218
19Abnormality of eosinophils (HP:0001879)2.89307082
20Hepatic necrosis (HP:0002605)2.87987901
21Congenital stationary night blindness (HP:0007642)2.71725654
22Increased serum lactate (HP:0002151)2.71488206
23Lipid accumulation in hepatocytes (HP:0006561)2.70964824
24Severe combined immunodeficiency (HP:0004430)2.69198232
25Abolished electroretinogram (ERG) (HP:0000550)2.68058503
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63299155
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63299155
28Acute encephalopathy (HP:0006846)2.57264947
29Aplasia/Hypoplasia of the sternum (HP:0006714)2.56143778
30Atrophy/Degeneration involving motor neurons (HP:0007373)2.56034169
31Distal arthrogryposis (HP:0005684)2.54713825
32Prostate neoplasm (HP:0100787)2.52497715
33Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.50300844
34Brittle hair (HP:0002299)2.48483087
35Keratoconjunctivitis sicca (HP:0001097)2.47901474
36Progressive macrocephaly (HP:0004481)2.41952877
37Lactic acidosis (HP:0003128)2.41242012
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37305228
39Increased hepatocellular lipid droplets (HP:0006565)2.36476755
40Peripheral hypomyelination (HP:0007182)2.35004575
41Premature loss of primary teeth (HP:0006323)2.31882215
42Progressive microcephaly (HP:0000253)2.27908928
43Abnormality of the prostate (HP:0008775)2.27830273
44Broad alveolar ridges (HP:0000187)2.27511616
45Progressive inability to walk (HP:0002505)2.25989754
46Abnormality of the renal cortex (HP:0011035)2.25988869
47Nephronophthisis (HP:0000090)2.25976637
48Eosinophilia (HP:0001880)2.25397456
49Abnormality of T cell number (HP:0011839)2.23831167
50Hypoplasia of the pons (HP:0012110)2.22185154
51Abnormality of macular pigmentation (HP:0008002)2.17357281
52Pachygyria (HP:0001302)2.16677325
53Keratitis (HP:0000491)2.16589528
54Cerebral edema (HP:0002181)2.15992866
55T lymphocytopenia (HP:0005403)2.14680351
56Combined immunodeficiency (HP:0005387)2.14625309
57Abnormality of the pons (HP:0007361)2.13202351
58Abnormality of the alveolar ridges (HP:0006477)2.11175126
59Optic disc pallor (HP:0000543)2.10923863
60Medial flaring of the eyebrow (HP:0010747)2.10095324
61Renal Fanconi syndrome (HP:0001994)2.00485056
62Abnormality of dental color (HP:0011073)1.99622737
63Inability to walk (HP:0002540)1.98895368
64Erythroderma (HP:0001019)1.98709243
65Absent thumb (HP:0009777)1.97837604
66Abnormality of the labia minora (HP:0012880)1.94339739
67Failure to thrive in infancy (HP:0001531)1.92330305
68Type II lissencephaly (HP:0007260)1.91736073
69Hypoproteinemia (HP:0003075)1.89465074
70Methylmalonic aciduria (HP:0012120)1.88328832
71Granulocytopenia (HP:0001913)1.87823496
723-Methylglutaconic aciduria (HP:0003535)1.86617312
73Aplasia/Hypoplasia of the hallux (HP:0008362)1.86385542
74Sclerocornea (HP:0000647)1.85519628
75Lissencephaly (HP:0001339)1.84169143
76Abnormality of the distal phalanges of the toes (HP:0010182)1.83395965
77Polyphagia (HP:0002591)1.82987024
78Stomach cancer (HP:0012126)1.81806384
79Respiratory failure (HP:0002878)1.80391652
80Methylmalonic acidemia (HP:0002912)1.79225616
81Dialeptic seizures (HP:0011146)1.78942834
82Ependymoma (HP:0002888)1.78096777
83Pancreatic cysts (HP:0001737)1.76300931
84Sparse eyelashes (HP:0000653)1.76230364
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.76058390
86Aplasia/hypoplasia of the uterus (HP:0008684)1.75931210
87Opisthotonus (HP:0002179)1.75814174
88Pendular nystagmus (HP:0012043)1.75483959
89Abnormality of alanine metabolism (HP:0010916)1.74017241
90Hyperalaninemia (HP:0003348)1.74017241
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74017241
92Nephrogenic diabetes insipidus (HP:0009806)1.73121236
93Abnormality of the renal medulla (HP:0100957)1.70452239
94Pancytopenia (HP:0001876)1.68967879
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68863414
96Exercise intolerance (HP:0003546)1.68207285
97Chromsome breakage (HP:0040012)1.68138509
98Encephalitis (HP:0002383)1.67802506
99Duplicated collecting system (HP:0000081)1.67749887
100CNS demyelination (HP:0007305)1.67513216

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.17518316
2TESK23.45017474
3TAOK33.27228425
4TXK3.05459383
5MAP2K22.82306629
6NUAK12.60452102
7BCKDK2.48543481
8TLK12.36217571
9TRIM282.33079183
10KDR2.23547520
11BUB12.18660289
12BCR2.08833707
13SIK32.03504392
14MAP3K141.96722308
15VRK21.95139796
16ACVR1B1.88995660
17ZAK1.88267617
18MUSK1.80119168
19ERBB31.75816736
20CSNK1G21.73582075
21MATK1.64175706
22EPHA31.61698694
23MAP3K41.56109412
24GRK61.46697528
25SRPK11.45489210
26GRK11.42829650
27CSNK1G31.39176560
28VRK11.34276501
29WNK31.33548386
30CSNK1A1L1.32457423
31MAP4K11.30208923
32ADRBK21.28074854
33RPS6KA41.21972664
34ARAF1.18174273
35OXSR11.17086434
36TSSK61.14515969
37LIMK11.10880231
38IKBKB1.04542183
39FES1.04494302
40CSNK1G11.00713065
41PLK41.00430742
42MAPK130.93878631
43PLK30.87816757
44CDC70.85176648
45IRAK40.85007451
46BMPR20.84885852
47PRKCQ0.84480227
48MAPKAPK30.84090568
49INSRR0.82997859
50WNK40.78967326
51RPS6KA50.76092802
52STK160.75348647
53DAPK10.75343404
54RAF10.72967790
55MST40.72221531
56MARK30.70527159
57STK390.68959772
58CDK190.67612624
59ATR0.65207838
60PAK60.64109177
61EPHA40.62310237
62CLK10.59493101
63KIT0.57168479
64ITK0.56637844
65CDK40.53513608
66TBK10.52187284
67MAP2K70.52182680
68PLK10.52030983
69PIM20.51745487
70LCK0.50863584
71PIM10.49750270
72IKBKE0.48484759
73MKNK10.45804923
74TIE10.44833124
75FRK0.43948109
76PRKCE0.43279790
77AURKB0.42084077
78BRD40.41965280
79CCNB10.41724739
80PLK20.41704930
81TTK0.40792856
82SYK0.40681392
83EIF2AK20.40491996
84AURKA0.39523585
85TEC0.38355242
86MKNK20.38240560
87MAP2K10.38175718
88EIF2AK30.37314487
89IGF1R0.36480754
90NEK10.35667068
91JAK10.34538573
92PHKG20.34058952
93PHKG10.34058952
94TESK10.33800809
95CDK30.33564757
96LYN0.33371138
97CSNK1A10.32752983
98PRKCI0.31713681
99STK38L0.29197343
100PINK10.29105121

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.95729566
2Proteasome_Homo sapiens_hsa030503.62301105
3Mismatch repair_Homo sapiens_hsa034302.70643599
4RNA polymerase_Homo sapiens_hsa030202.38209078
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25778423
6DNA replication_Homo sapiens_hsa030302.25605440
7Base excision repair_Homo sapiens_hsa034102.20202718
8Non-homologous end-joining_Homo sapiens_hsa034502.04175868
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.96526944
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95106374
11Nucleotide excision repair_Homo sapiens_hsa034201.92228328
12Oxidative phosphorylation_Homo sapiens_hsa001901.92082395
13Graft-versus-host disease_Homo sapiens_hsa053321.91006069
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87774521
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85396096
16Primary immunodeficiency_Homo sapiens_hsa053401.83017491
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79058092
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73765830
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71716241
20Parkinsons disease_Homo sapiens_hsa050121.69889488
21Spliceosome_Homo sapiens_hsa030401.68031240
22Protein export_Homo sapiens_hsa030601.65623365
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62509574
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60848910
25Homologous recombination_Homo sapiens_hsa034401.58635628
26Fatty acid elongation_Homo sapiens_hsa000621.55953110
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52798041
28Fanconi anemia pathway_Homo sapiens_hsa034601.51626387
29RNA degradation_Homo sapiens_hsa030181.47828866
30One carbon pool by folate_Homo sapiens_hsa006701.46251233
31Basal transcription factors_Homo sapiens_hsa030221.44162748
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42437141
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.40830798
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.38159651
35Phototransduction_Homo sapiens_hsa047441.36465237
36Pyrimidine metabolism_Homo sapiens_hsa002401.33413994
37Antigen processing and presentation_Homo sapiens_hsa046121.22810533
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22776036
39Type I diabetes mellitus_Homo sapiens_hsa049401.08925494
40Steroid biosynthesis_Homo sapiens_hsa001001.08889778
41Purine metabolism_Homo sapiens_hsa002301.07172333
42Autoimmune thyroid disease_Homo sapiens_hsa053201.06842318
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06699603
44Allograft rejection_Homo sapiens_hsa053301.05142961
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02414428
46Alzheimers disease_Homo sapiens_hsa050101.00396002
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95462804
48Huntingtons disease_Homo sapiens_hsa050160.93228970
49Peroxisome_Homo sapiens_hsa041460.90969743
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85455708
51Caffeine metabolism_Homo sapiens_hsa002320.84557644
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84394273
53Shigellosis_Homo sapiens_hsa051310.81757015
54Phenylalanine metabolism_Homo sapiens_hsa003600.80428776
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79226583
56Herpes simplex infection_Homo sapiens_hsa051680.76263915
57Nitrogen metabolism_Homo sapiens_hsa009100.74946874
58Asthma_Homo sapiens_hsa053100.73910563
59Sulfur metabolism_Homo sapiens_hsa009200.73766036
60Butanoate metabolism_Homo sapiens_hsa006500.73043179
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72814743
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72452530
63Propanoate metabolism_Homo sapiens_hsa006400.71523696
64Nicotine addiction_Homo sapiens_hsa050330.70684525
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69989784
66Rheumatoid arthritis_Homo sapiens_hsa053230.68576781
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68529292
68Biosynthesis of amino acids_Homo sapiens_hsa012300.68336840
69Arginine biosynthesis_Homo sapiens_hsa002200.67083564
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66737644
71RNA transport_Homo sapiens_hsa030130.66122846
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.64895719
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62739493
74Arginine and proline metabolism_Homo sapiens_hsa003300.61166039
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60767789
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60047573
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57341000
78Vitamin digestion and absorption_Homo sapiens_hsa049770.54357107
79Regulation of autophagy_Homo sapiens_hsa041400.53064302
80Metabolic pathways_Homo sapiens_hsa011000.52410227
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50739045
82T cell receptor signaling pathway_Homo sapiens_hsa046600.49976691
83Legionellosis_Homo sapiens_hsa051340.49886902
84Fat digestion and absorption_Homo sapiens_hsa049750.48164793
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45827466
86Tryptophan metabolism_Homo sapiens_hsa003800.43814458
87Fatty acid metabolism_Homo sapiens_hsa012120.42134393
88Linoleic acid metabolism_Homo sapiens_hsa005910.41363932
89Taste transduction_Homo sapiens_hsa047420.38041434
90Pyruvate metabolism_Homo sapiens_hsa006200.36577640
91Collecting duct acid secretion_Homo sapiens_hsa049660.36112209
92Viral myocarditis_Homo sapiens_hsa054160.31938530
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.31396443
94Tyrosine metabolism_Homo sapiens_hsa003500.30769846
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.30568244
96Cell cycle_Homo sapiens_hsa041100.30496520
97Epstein-Barr virus infection_Homo sapiens_hsa051690.30392121
98Carbon metabolism_Homo sapiens_hsa012000.29327010
99GABAergic synapse_Homo sapiens_hsa047270.29132249
100Circadian rhythm_Homo sapiens_hsa047100.29034972

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