GP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol acyl-chain remodeling (GO:0036149)8.40353240
2intestinal absorption (GO:0050892)8.12891301
3phosphatidylserine acyl-chain remodeling (GO:0036150)7.91101659
4cobalamin metabolic process (GO:0009235)7.86452579
5cholesterol catabolic process (GO:0006707)7.81399196
6sterol catabolic process (GO:0016127)7.81399196
7peptidyl-proline hydroxylation (GO:0019511)7.33871342
8phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.93993211
9negative regulation of digestive system process (GO:0060457)6.88555186
10regulation of phospholipase A2 activity (GO:0032429)6.65157276
11glycolipid catabolic process (GO:0019377)6.53555934
12membrane lipid catabolic process (GO:0046466)6.38827256
13cysteine metabolic process (GO:0006534)6.11319597
14Golgi transport vesicle coating (GO:0048200)5.97824204
15COPI coating of Golgi vesicle (GO:0048205)5.97824204
16phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.97148506
17regulation of keratinocyte proliferation (GO:0010837)5.86631436
18icosanoid transport (GO:0071715)5.82406313
19fatty acid derivative transport (GO:1901571)5.82406313
20protein hydroxylation (GO:0018126)5.64437395
21ceramide catabolic process (GO:0046514)5.63210070
22regulation of keratinocyte differentiation (GO:0045616)5.56660881
23branched-chain amino acid catabolic process (GO:0009083)5.56551430
24valine metabolic process (GO:0006573)5.49445719
25proline biosynthetic process (GO:0006561)5.45145135
26phosphatidylcholine acyl-chain remodeling (GO:0036151)5.13324889
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.01537628
28phosphatidylserine metabolic process (GO:0006658)4.95667397
29branched-chain amino acid metabolic process (GO:0009081)4.94750801
30cellular modified amino acid catabolic process (GO:0042219)4.85435817
31positive regulation of nuclease activity (GO:0032075)4.78605059
32protein maturation by protein folding (GO:0022417)4.76238680
33response to endoplasmic reticulum stress (GO:0034976)4.57238246
34endoplasmic reticulum unfolded protein response (GO:0030968)4.51206539
35zinc ion transport (GO:0006829)4.50699255
36cellular response to unfolded protein (GO:0034620)4.37870608
37mitochondrial calcium ion transport (GO:0006851)4.36917724
38regulation of nuclease activity (GO:0032069)4.35603965
39leukotriene biosynthetic process (GO:0019370)4.27128323
40homocysteine metabolic process (GO:0050667)4.23904196
414-hydroxyproline metabolic process (GO:0019471)4.21459029
42phospholipid catabolic process (GO:0009395)4.21371262
43mucosal immune response (GO:0002385)4.19950422
44positive regulation of heat generation (GO:0031652)4.18793523
45maintenance of protein localization in organelle (GO:0072595)4.18694870
46intestinal epithelial cell development (GO:0060576)4.18030258
47ER-nucleus signaling pathway (GO:0006984)4.17332506
48cellular response to topologically incorrect protein (GO:0035967)4.15574550
49regulation of acrosome reaction (GO:0060046)4.13937185
50serine family amino acid biosynthetic process (GO:0009070)4.11599599
51aspartate family amino acid catabolic process (GO:0009068)4.10804373
52alditol phosphate metabolic process (GO:0052646)4.07226615
53signal peptide processing (GO:0006465)4.05703212
54regulation of fever generation (GO:0031620)3.95014094
55phosphatidic acid biosynthetic process (GO:0006654)3.94942281
56phosphatidic acid metabolic process (GO:0046473)3.94942281
57glutamine metabolic process (GO:0006541)3.90517227
58creatine metabolic process (GO:0006600)3.90215560
59water-soluble vitamin metabolic process (GO:0006767)3.88811685
60steroid catabolic process (GO:0006706)3.88509177
61COPII vesicle coating (GO:0048208)3.85911619
62organ or tissue specific immune response (GO:0002251)3.78206563
63negative regulation of epidermal cell differentiation (GO:0045605)3.77212136
64neutrophil mediated immunity (GO:0002446)3.75864742
65coenzyme catabolic process (GO:0009109)3.74642057
66endocrine pancreas development (GO:0031018)3.71985210
67ER overload response (GO:0006983)3.71078653
68ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.69794890
69sphingolipid catabolic process (GO:0030149)3.64140700
70proline metabolic process (GO:0006560)3.60812782
71response to unfolded protein (GO:0006986)3.59045961
72retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.58098571
73negative regulation of epithelial cell differentiation (GO:0030857)3.54827187
74acute-phase response (GO:0006953)3.50146326
75GDP-mannose metabolic process (GO:0019673)3.49567181
76antibacterial humoral response (GO:0019731)3.48444993
77regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.46172146
78response to topologically incorrect protein (GO:0035966)3.45131021
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.40782034
80L-phenylalanine catabolic process (GO:0006559)3.40782034
81phosphatidylglycerol metabolic process (GO:0046471)3.40264158
82defense response to Gram-positive bacterium (GO:0050830)3.39968175
83protein N-linked glycosylation via asparagine (GO:0018279)3.30604154
84mitochondrion distribution (GO:0048311)3.30343608
85peptidyl-asparagine modification (GO:0018196)3.28739264
86L-serine metabolic process (GO:0006563)3.26045988
87antimicrobial humoral response (GO:0019730)3.22925843
88sterol transport (GO:0015918)3.21270890
89cholesterol transport (GO:0030301)3.21270890
90L-phenylalanine metabolic process (GO:0006558)3.20382636
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.20382636
92regulation of heat generation (GO:0031650)3.18863673
93serine family amino acid metabolic process (GO:0009069)3.16691637
94endothelial cell migration (GO:0043542)3.15746301
95leukotriene metabolic process (GO:0006691)3.13693035
96positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.12523675
97arachidonic acid secretion (GO:0050482)3.11979326
98icosanoid secretion (GO:0032309)3.11979326
99cell redox homeostasis (GO:0045454)3.09131914
100L-alpha-amino acid transmembrane transport (GO:1902475)3.07912517
101biotin metabolic process (GO:0006768)3.06915897
102regulation of epidermal cell differentiation (GO:0045604)3.06757152
103protein N-linked glycosylation (GO:0006487)3.01335563
104regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)3.01314362
105digestive system process (GO:0022600)2.96586360
106vitamin metabolic process (GO:0006766)2.96106354
107phototransduction, visible light (GO:0007603)2.94568077
108innate immune response in mucosa (GO:0002227)2.93842509
109retinoid metabolic process (GO:0001523)2.93745951
110regulation of digestive system process (GO:0044058)2.89552765
111daunorubicin metabolic process (GO:0044597)2.88035816
112polyketide metabolic process (GO:0030638)2.88035816
113doxorubicin metabolic process (GO:0044598)2.88035816
114myeloid leukocyte mediated immunity (GO:0002444)2.85655849
115S-adenosylmethionine metabolic process (GO:0046500)2.84418080
116regulation of oxidative stress-induced cell death (GO:1903201)2.84380443
117polarized epithelial cell differentiation (GO:0030859)2.81344202
118sulfur amino acid biosynthetic process (GO:0000097)2.80944807
119negative regulation of epidermis development (GO:0045683)2.80419326
120aminoglycoside antibiotic metabolic process (GO:0030647)2.79208620
121glycine transport (GO:0015816)2.78841468
122diterpenoid metabolic process (GO:0016101)2.78714640
123pancreas development (GO:0031016)2.77501335
124retinoic acid receptor signaling pathway (GO:0048384)2.75468453
125peptide catabolic process (GO:0043171)2.74301288
126multicellular organismal catabolic process (GO:0044243)2.73500724
127tetrapyrrole metabolic process (GO:0033013)2.69988850
128alpha-amino acid biosynthetic process (GO:1901607)2.68701416
129detection of visible light (GO:0009584)2.68650663
130cellular protein catabolic process (GO:0044257)2.68025076
131lysine metabolic process (GO:0006553)2.65461701
132long-chain fatty acid transport (GO:0015909)2.57910300
133positive regulation of wound healing (GO:0090303)2.56657327
134alcohol catabolic process (GO:0046164)2.53485832
135regulation of cholesterol homeostasis (GO:2000188)2.50031582
136terpenoid metabolic process (GO:0006721)2.48575481
137cellular response to zinc ion (GO:0071294)2.47942750
138lipid catabolic process (GO:0016042)2.45246769
139multicellular organismal metabolic process (GO:0044236)2.44790466
140cholesterol metabolic process (GO:0008203)2.44747791
141acute inflammatory response (GO:0002526)2.44726795
142phototransduction (GO:0007602)2.44601675
143fatty acid derivative biosynthetic process (GO:1901570)2.42102845
144icosanoid biosynthetic process (GO:0046456)2.42102845
145regulation of calcium ion-dependent exocytosis (GO:0017158)2.41798547
146detection of light stimulus (GO:0009583)2.33612386
147epithelial cell migration (GO:0010631)2.30022040
148positive regulation of calcium ion transport into cytosol (GO:0010524)2.29507535
149organic hydroxy compound transport (GO:0015850)2.24835414
150sterol metabolic process (GO:0016125)2.24406777
151calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.24223332
152acid secretion (GO:0046717)2.20932549
153phosphatidylcholine metabolic process (GO:0046470)2.20089552
154isoprenoid metabolic process (GO:0006720)2.16908002
155macroautophagy (GO:0016236)2.15890883
156maintenance of gastrointestinal epithelium (GO:0030277)2.15105559
157L-fucose metabolic process (GO:0042354)2.14172453
158L-fucose catabolic process (GO:0042355)2.14172453
159intestinal cholesterol absorption (GO:0030299)18.7161365
160exocrine pancreas development (GO:0031017)16.0980177
161digestion (GO:0007586)14.0570615
162protein retention in ER lumen (GO:0006621)12.3036371
163maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.5252911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.27338760
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.15090155
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.96660884
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.71604368
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.17226136
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.14994126
7ERG_21242973_ChIP-ChIP_JURKAT_Human3.04675896
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.85208619
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.65396990
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.63192390
11GATA4_25053715_ChIP-Seq_YYC3_Human2.54113073
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.52525515
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44469798
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.37050480
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.30920619
16GATA1_22025678_ChIP-Seq_K562_Human2.25720716
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.13052898
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.10589481
19GATA6_25053715_ChIP-Seq_YYC3_Human2.10453760
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08950424
21VDR_22108803_ChIP-Seq_LS180_Human1.96070291
22PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.91784538
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91078263
24HTT_18923047_ChIP-ChIP_STHdh_Human1.88939627
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78519030
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77526746
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77526746
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77526746
29ETV1_20927104_ChIP-Seq_GIST48_Human1.70189536
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69344019
31TAF15_26573619_Chip-Seq_HEK293_Human1.64949739
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.60452719
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57059198
34PHF8_20622853_ChIP-Seq_HELA_Human1.56134577
35NFYA_21822215_ChIP-Seq_K562_Human1.55404498
36P300_19829295_ChIP-Seq_ESCs_Human1.54661467
37HNFA_21074721_ChIP-Seq_CACO-2_Human1.52800634
38PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.52466253
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50915652
40GBX2_23144817_ChIP-Seq_PC3_Human1.50892906
41RBPJ_21746931_ChIP-Seq_IB4_Human1.49990656
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.48878582
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47082881
44EGR1_19032775_ChIP-ChIP_M12_Human1.46532258
45CBX2_22325352_ChIP-Seq_293T-Rex_Human1.46156530
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.45733535
47GATA6_21074721_ChIP-Seq_CACO-2_Human1.44877326
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43727893
49P63_26484246_Chip-Seq_KERATINOCYTES_Human1.42372249
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40459734
51GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.39474989
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38904365
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38477325
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.38371287
55CHD1_26751641_Chip-Seq_LNCaP_Human1.38082436
56CREB1_26743006_Chip-Seq_LNCaP_Human1.37670513
57NFYB_21822215_ChIP-Seq_K562_Human1.35271348
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.34195564
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.32926900
60* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.30716398
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30305540
62SOX2_20726797_ChIP-Seq_SW620_Human1.30108773
63AR_20517297_ChIP-Seq_VCAP_Human1.29574855
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.27216804
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26477914
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25558463
67ERG_20517297_ChIP-Seq_VCAP_Human1.25216400
68LXR_22292898_ChIP-Seq_THP-1_Human1.25146057
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23982435
70P68_20966046_ChIP-Seq_HELA_Human1.23551425
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23459906
72CLOCK_20551151_ChIP-Seq_293T_Human1.22817661
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22779867
74NANOG_19829295_ChIP-Seq_ESCs_Human1.22671731
75SOX2_19829295_ChIP-Seq_ESCs_Human1.22671731
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22402980
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.22046153
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22046153
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20172636
80CDX2_22108803_ChIP-Seq_LS180_Human1.19827632
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19570229
82CBP_20019798_ChIP-Seq_JUKART_Human1.19570229
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19227810
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19095525
85FOXH1_21741376_ChIP-Seq_ESCs_Human1.17956970
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.16891025
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16446882
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16286554
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15785241
90FOXA2_19822575_ChIP-Seq_HepG2_Human1.15618489
91TP63_22573176_ChIP-Seq_HFKS_Human1.15280576
92ATF3_27146783_Chip-Seq_COLON_Human1.14915770
93TBL1_22424771_ChIP-Seq_293T_Human1.14617739
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14440309
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14114025
96ESET_19884257_ChIP-Seq_ESCs_Mouse1.13442339
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.12238333
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.11864492
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11734454
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.11398293
101HOXB7_26014856_ChIP-Seq_BT474_Human1.07298141
102FOXH1_21741376_ChIP-Seq_EPCs_Human1.06902350
103ER_23166858_ChIP-Seq_MCF-7_Human1.06115229
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05355206
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05273391
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04426322
107CTCF_27219007_Chip-Seq_Bcells_Human1.04205561
108TAF2_19829295_ChIP-Seq_ESCs_Human1.04089239
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03912107
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03253646
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02918540
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02798224
113RUNX2_22187159_ChIP-Seq_PCA_Human1.01443434
114ETS1_21867929_ChIP-Seq_TH2_Mouse1.00477151
115EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00299384
116OCT4_20526341_ChIP-Seq_ESCs_Human1.00175531
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00005798
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99458321
119RACK7_27058665_Chip-Seq_MCF-7_Human0.99164763
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98966562
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98628177
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98351630
123CBP_21632823_ChIP-Seq_H3396_Human0.98329126
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98086188
125GATA3_24758297_ChIP-Seq_MCF-7_Human0.97683443
126MYC_19829295_ChIP-Seq_ESCs_Human0.96565930
127SMAD4_21799915_ChIP-Seq_A2780_Human0.96323884
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96101050
129P53_21459846_ChIP-Seq_SAOS-2_Human0.96070973
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96058860
131FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95867310
132AR_25329375_ChIP-Seq_VCAP_Human0.94720777
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94301525
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93853359
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93698362
136SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93518374
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93478848
138* FOXA1_25552417_ChIP-Seq_VCAP_Human0.93447420
139ZNF274_21170338_ChIP-Seq_K562_Hela0.93093949
140CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93054144
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92353301
142GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91916065
143BCOR_27268052_Chip-Seq_Bcells_Human0.91701642
144KLF4_19829295_ChIP-Seq_ESCs_Human0.91314708
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.91166362
146TBX20_22080862_ChIP-Seq_HEART_Mouse0.91166362
147TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90679750
148* REST_21632747_ChIP-Seq_MESCs_Mouse0.90251921
149STAT3_23295773_ChIP-Seq_U87_Human0.89498043
150RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88594169
151KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88573352
152IRF1_19129219_ChIP-ChIP_H3396_Human0.88290244
153BCAT_22108803_ChIP-Seq_LS180_Human0.87770793
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87703132
155SA1_27219007_Chip-Seq_Bcells_Human0.86975101
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85602294
157* ERA_21632823_ChIP-Seq_H3396_Human0.85286480
158TP53_18474530_ChIP-ChIP_U2OS_Human0.84891238
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.84435385
160TCF4_23295773_ChIP-Seq_U87_Human0.83820549
161* CTCF_20526341_ChIP-Seq_ESCs_Human0.83244546
162TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83076962
163SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.82847141
164PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81965838
165NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81657704
166GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80293185
167KLF5_25053715_ChIP-Seq_YYC3_Human0.79462472
168CEBPB_22108803_ChIP-Seq_LS180_Human0.78427694
169KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78313690
170RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77843593
171FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76424555
172SMC4_20622854_ChIP-Seq_HELA_Human0.76381194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.38580289
2MP0001666_abnormal_nutrient_absorption9.21236235
3MP0005365_abnormal_bile_salt6.57077767
4MP0005220_abnormal_exocrine_pancreas6.37789204
5MP0003868_abnormal_feces_composition5.06818489
6MP0005084_abnormal_gallbladder_morpholo4.86196982
7MP0005085_abnormal_gallbladder_physiolo3.39913321
8MP0002693_abnormal_pancreas_physiology2.80871120
9MP0003959_abnormal_lean_body2.64949626
10MP0001664_abnormal_digestion2.39760170
11MP0002138_abnormal_hepatobiliary_system2.34209297
12MP0002139_abnormal_hepatobiliary_system2.15927495
13MP0003705_abnormal_hypodermis_morpholog1.90374333
14MP0001944_abnormal_pancreas_morphology1.90325836
15MP0004264_abnormal_extraembryonic_tissu1.76910379
16MP0010386_abnormal_urinary_bladder1.71512212
17MP0010234_abnormal_vibrissa_follicle1.69121442
18MP0005448_abnormal_energy_balance1.68899785
19MP0003252_abnormal_bile_duct1.58446842
20MP0004233_abnormal_muscle_weight1.51699508
21MP0003638_abnormal_response/metabolism_1.39362729
22MP0008004_abnormal_stomach_pH1.38572469
23MP0002277_abnormal_respiratory_mucosa1.32856534
24MP0002118_abnormal_lipid_homeostasis1.32741205
25MP0002928_abnormal_bile_duct1.26783214
26MP0005165_increased_susceptibility_to1.25315769
27MP0001501_abnormal_sleep_pattern1.19921868
28MP0003011_delayed_dark_adaptation1.17724083
29MP0002163_abnormal_gland_morphology1.17620891
30MP0005332_abnormal_amino_acid1.16391373
31MP0002078_abnormal_glucose_homeostasis1.08159421
32MP0000470_abnormal_stomach_morphology1.07980546
33MP0005451_abnormal_body_composition1.04118591
34MP0008872_abnormal_physiological_respon0.98713854
35MP0000003_abnormal_adipose_tissue0.94463924
36MP0001502_abnormal_circadian_rhythm0.92487111
37MP0001873_stomach_inflammation0.87448980
38MP0008789_abnormal_olfactory_epithelium0.87329361
39MP0008875_abnormal_xenobiotic_pharmacok0.86774187
40MP0002132_abnormal_respiratory_system0.85907638
41MP0005535_abnormal_body_temperature0.85268447
42MP0005408_hypopigmentation0.85252423
43MP0009643_abnormal_urine_homeostasis0.80802544
44MP0008961_abnormal_basal_metabolism0.79915695
45MP0005379_endocrine/exocrine_gland_phen0.78791008
46MP0003045_fibrosis0.78640706
47MP0001756_abnormal_urination0.78503768
48MP0009384_cardiac_valve_regurgitation0.76942383
49MP0003878_abnormal_ear_physiology0.76823705
50MP0005377_hearing/vestibular/ear_phenot0.76823705
51MP0003953_abnormal_hormone_level0.74765329
52MP0000613_abnormal_salivary_gland0.74066556
53MP0001765_abnormal_ion_homeostasis0.72251750
54MP0003806_abnormal_nucleotide_metabolis0.71776966
55MP0004019_abnormal_vitamin_homeostasis0.71654169
56MP0003300_gastrointestinal_ulcer0.70515509
57MP0002796_impaired_skin_barrier0.68422772
58MP0006054_spinal_hemorrhage0.68213139
59MP0002909_abnormal_adrenal_gland0.67648513
60MP0008438_abnormal_cutaneous_collagen0.67166862
61MP0001485_abnormal_pinna_reflex0.67118944
62MP0005645_abnormal_hypothalamus_physiol0.66846807
63MP0000490_abnormal_crypts_of0.66359896
64MP0005058_abnormal_lysosome_morphology0.65690959
65MP0002837_dystrophic_cardiac_calcinosis0.64606672
66MP0005636_abnormal_mineral_homeostasis0.64352881
67MP0005394_taste/olfaction_phenotype0.63146967
68MP0005499_abnormal_olfactory_system0.63146967
69MP0005646_abnormal_pituitary_gland0.61720752
70MP0005452_abnormal_adipose_tissue0.61671297
71MP0003879_abnormal_hair_cell0.61610636
72MP0005410_abnormal_fertilization0.61604734
73MP0008995_early_reproductive_senescence0.61030133
74MP0009780_abnormal_chondrocyte_physiolo0.60990688
75MP0002168_other_aberrant_phenotype0.59878361
76MP0001663_abnormal_digestive_system0.57760357
77MP0006036_abnormal_mitochondrial_physio0.57215068
78MP0005551_abnormal_eye_electrophysiolog0.56127578
79MP0004185_abnormal_adipocyte_glucose0.55748987
80MP0003283_abnormal_digestive_organ0.55312660
81MP0000598_abnormal_liver_morphology0.54747699
82MP0010329_abnormal_lipoprotein_level0.52685454
83MP0004145_abnormal_muscle_electrophysio0.52616885
84MP0000371_diluted_coat_color0.52067249
85MP0005375_adipose_tissue_phenotype0.51069856
86MP0002234_abnormal_pharynx_morphology0.50726734
87MP0002098_abnormal_vibrissa_morphology0.50571943
88MP0003646_muscle_fatigue0.49491898
89MP0000538_abnormal_urinary_bladder0.49472582
90MP0002970_abnormal_white_adipose0.49463756
91MP0000609_abnormal_liver_physiology0.49062009
92MP0002876_abnormal_thyroid_physiology0.48909751
93MP0000750_abnormal_muscle_regeneration0.48259135
94MP0001764_abnormal_homeostasis0.47582868
95MP0003186_abnormal_redox_activity0.47160743
96MP0001731_abnormal_postnatal_growth0.46963168
97MP0003950_abnormal_plasma_membrane0.46528821
98MP0005381_digestive/alimentary_phenotyp0.46196948
99MP0009765_abnormal_xenobiotic_induced0.45530028
100MP0002009_preneoplasia0.44121492
101MP0004147_increased_porphyrin_level0.42737380
102MP0002060_abnormal_skin_morphology0.41811435
103MP0002089_abnormal_postnatal_growth/wei0.41440907
104MP0001845_abnormal_inflammatory_respons0.39867077
105MP0005319_abnormal_enzyme/_coenzyme0.39279769
106MP0008877_abnormal_DNA_methylation0.38927821
107MP0002638_abnormal_pupillary_reflex0.38615148
108MP0000462_abnormal_digestive_system0.38541486
109MP0000377_abnormal_hair_follicle0.37769313
110MP0002896_abnormal_bone_mineralization0.37467767
111MP0004043_abnormal_pH_regulation0.36876847
112MP0010678_abnormal_skin_adnexa0.36641852
113MP0001348_abnormal_lacrimal_gland0.36454189
114MP0000383_abnormal_hair_follicle0.36321546
115MP0000367_abnormal_coat/_hair0.35729825
116MP0003183_abnormal_peptide_metabolism0.35527939
117MP0005334_abnormal_fat_pad0.34958345
118MP0005360_urolithiasis0.34733378
119MP0003795_abnormal_bone_structure0.34725001
120MP0000230_abnormal_systemic_arterial0.33548916
121MP0003866_abnormal_defecation0.33427168
122MP0005395_other_phenotype0.32680714
123MP0006072_abnormal_retinal_apoptosis0.31685376
124MP0000579_abnormal_nail_morphology0.31603816
125MP0003656_abnormal_erythrocyte_physiolo0.31560785
126MP0005253_abnormal_eye_physiology0.31443692
127MP0000647_abnormal_sebaceous_gland0.31433913
128MP0002102_abnormal_ear_morphology0.30760794
129MP0003329_amyloid_beta_deposits0.30057994
130MP0002877_abnormal_melanocyte_morpholog0.30047068
131MP0006276_abnormal_autonomic_nervous0.29971334
132MP0002069_abnormal_eating/drinking_beha0.29509180
133MP0002136_abnormal_kidney_physiology0.29479788
134MP0004085_abnormal_heartbeat0.28742957
135MP0009642_abnormal_blood_homeostasis0.27563834
136MP0000427_abnormal_hair_cycle0.27438377
137MP0005187_abnormal_penis_morphology0.24823252
138MP0000631_abnormal_neuroendocrine_gland0.24164045
139MP0008770_decreased_survivor_rate0.23931075
140MP0009703_decreased_birth_body0.23791162
141MP0002272_abnormal_nervous_system0.23702335
142MP0003453_abnormal_keratinocyte_physiol0.23541928
143MP0004484_altered_response_of0.23524561
144MP0003195_calcinosis0.23337080
145MP0004130_abnormal_muscle_cell0.22634227
146MP0003943_abnormal_hepatobiliary_system0.20590091
147MP0002254_reproductive_system_inflammat0.19900160
148MP0005386_behavior/neurological_phenoty0.19637830
149MP0004924_abnormal_behavior0.19637830
150MP0003956_abnormal_body_size0.19421310

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)8.83937181
2Fat malabsorption (HP:0002630)7.34751120
3Gout (HP:0001997)6.89541405
4Exocrine pancreatic insufficiency (HP:0001738)5.49685190
5Short chin (HP:0000331)5.43747649
6Decreased subcutaneous fat (HP:0001002)5.29755938
7Type I diabetes mellitus (HP:0100651)4.89043213
8Abnormality of subcutaneous fat tissue (HP:0001001)4.75551964
9Abnormal pancreas size (HP:0012094)4.53289670
10Abnormality of the intrinsic pathway (HP:0010989)4.50715129
11Maternal diabetes (HP:0009800)4.27728033
12Hypoplasia of the pons (HP:0012110)4.10254165
13Abnormality of the pons (HP:0007361)3.84761261
14Ketoacidosis (HP:0001993)3.81428814
15Abnormality of the pleura (HP:0002103)3.79014506
16Pancreatitis (HP:0001733)3.78482472
17Ketosis (HP:0001946)3.75367118
18Premature skin wrinkling (HP:0100678)3.72622414
19Tubulointerstitial fibrosis (HP:0005576)3.71530183
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69208723
21Tubulointerstitial nephritis (HP:0001970)3.57764349
22Hypoproteinemia (HP:0003075)3.57732757
23Abnormality of the pancreatic islet cells (HP:0006476)3.51157949
24Abnormality of endocrine pancreas physiology (HP:0012093)3.51157949
25Cortical dysplasia (HP:0002539)3.45347488
26Joint stiffness (HP:0001387)3.42580452
27Hypoglycemic coma (HP:0001325)3.25697674
28Increased purine levels (HP:0004368)3.20912429
29Hyperuricemia (HP:0002149)3.20912429
30Carpal bone hypoplasia (HP:0001498)3.17112805
31Hypoglycemic seizures (HP:0002173)2.95928149
32Decreased circulating renin level (HP:0003351)2.90537904
33Hyperglycinemia (HP:0002154)2.88662341
34Abnormality of the common coagulation pathway (HP:0010990)2.82437752
35Long foot (HP:0001833)2.81348585
36Late onset (HP:0003584)2.80492955
37Hyperinsulinemic hypoglycemia (HP:0000825)2.73844480
38Abnormality of sulfur amino acid metabolism (HP:0004339)2.64188025
39Ventricular fibrillation (HP:0001663)2.61176668
40Hyperglycinuria (HP:0003108)2.58652175
41Abnormal tarsal ossification (HP:0008369)2.57858914
42Right ventricular cardiomyopathy (HP:0011663)2.49162922
43Abnormality of proline metabolism (HP:0010907)2.47089029
44Hydroxyprolinuria (HP:0003080)2.47089029
45Pancreatic cysts (HP:0001737)2.44956048
46Prenatal maternal abnormality (HP:0002686)2.43433845
47Abnormality of glycine metabolism (HP:0010895)2.41434084
48Abnormality of serine family amino acid metabolism (HP:0010894)2.41434084
49Optic nerve hypoplasia (HP:0000609)2.41126266
50Anal atresia (HP:0002023)2.40212050
51Vascular calcification (HP:0004934)2.39185478
52Cerebellar dysplasia (HP:0007033)2.36403505
53Progressive muscle weakness (HP:0003323)2.35821002
54Hypoplasia of the odontoid process (HP:0003311)2.35578334
55Congenital glaucoma (HP:0001087)2.34382555
56Acute hepatic failure (HP:0006554)2.33088406
57Abnormal protein glycosylation (HP:0012346)2.32943094
58Abnormal glycosylation (HP:0012345)2.32943094
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32943094
60Abnormal protein N-linked glycosylation (HP:0012347)2.32943094
61Small epiphyses (HP:0010585)2.30603515
62Fatigue (HP:0012378)2.28927935
63Esophageal varix (HP:0002040)2.28019789
64Hyperglycemia (HP:0003074)2.26784198
65Abnormality of the renal cortex (HP:0011035)2.21537116
66Pectus carinatum (HP:0000768)2.21492081
67Ileus (HP:0002595)2.18580048
68Abnormality of purine metabolism (HP:0004352)2.17784644
69Congenital, generalized hypertrichosis (HP:0004540)2.16750858
70Dysostosis multiplex (HP:0000943)2.16200101
71Tubulointerstitial abnormality (HP:0001969)2.13206462
72Chronic hepatic failure (HP:0100626)2.10102332
73Hypoplasia of the uterus (HP:0000013)2.09848692
74Unilateral renal agenesis (HP:0000122)2.09668641
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06358552
76Barrel-shaped chest (HP:0001552)2.05757998
77Abnormality of renin-angiotensin system (HP:0000847)2.05688573
78Abnormality of glutamine family amino acid metabolism (HP:0010902)2.04822399
79Prolonged QT interval (HP:0001657)2.02874676
80Abnormality of the renal medulla (HP:0100957)2.02724319
81Tubular atrophy (HP:0000092)2.01311291
82Azoospermia (HP:0000027)2.00987064
83Type II lissencephaly (HP:0007260)2.00594616
84Ankyloglossia (HP:0010296)1.99417763
85Symptomatic seizures (HP:0011145)1.98966973
86Cardiovascular calcification (HP:0011915)1.98445714
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98385645
88Vacuolated lymphocytes (HP:0001922)1.97501946
89Myocardial infarction (HP:0001658)1.97419194
90Hyperactive renin-angiotensin system (HP:0000841)1.96635347
91Cortical visual impairment (HP:0100704)1.95087801
92Medial flaring of the eyebrow (HP:0010747)1.93774293
93Conjugated hyperbilirubinemia (HP:0002908)1.93306417
94Abnormality of methionine metabolism (HP:0010901)1.92884439
95Large for gestational age (HP:0001520)1.90922385
96Congenital stationary night blindness (HP:0007642)1.88734022
97Abnormal foot bone ossification (HP:0010675)1.87975132
98Abnormality of chloride homeostasis (HP:0011422)1.87929798
99Renal salt wasting (HP:0000127)1.87895032
100Abnormality of the odontoid process (HP:0003310)1.86232799
101Abnormal biliary tract morphology (HP:0012440)1.85334165
102Type I transferrin isoform profile (HP:0003642)1.85229775
103Rectal prolapse (HP:0002035)1.83979884
104Limb hypertonia (HP:0002509)1.83183981
105Homocystinuria (HP:0002156)1.81417871
106Abnormality of homocysteine metabolism (HP:0010919)1.81417871
107Glycosuria (HP:0003076)1.79513851
108Abnormality of urine glucose concentration (HP:0011016)1.79513851
109Methylmalonic aciduria (HP:0012120)1.79469169
110Male infertility (HP:0003251)1.79026299
111Popliteal pterygium (HP:0009756)1.78902470
112Hyperaldosteronism (HP:0000859)1.77269887
113Opisthotonus (HP:0002179)1.76698800
114Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75509119
115Abnormality of the nasal septum (HP:0000419)1.75428124
116Severe short stature (HP:0003510)1.74251554
117Myopathic facies (HP:0002058)1.74157736
118Genetic anticipation (HP:0003743)1.74145476
119Large hands (HP:0001176)1.72232419
120Beaking of vertebral bodies (HP:0004568)1.71732466
121Hypsarrhythmia (HP:0002521)1.71659803
122Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70867867
123Neonatal death (HP:0003811)1.70098965
124Flat acetabular roof (HP:0003180)1.68240133
125Glomerulosclerosis (HP:0000096)1.68145555
126Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68067039
127Hypokalemic alkalosis (HP:0001949)1.67757675
128Gaze-evoked nystagmus (HP:0000640)1.67401977
129Polydipsia (HP:0001959)1.67303375
130Abnormal drinking behavior (HP:0030082)1.67303375
131Congenital sensorineural hearing impairment (HP:0008527)1.67124801
132Potter facies (HP:0002009)1.66908429
133Facial shape deformation (HP:0011334)1.66908429
134Flattened epiphyses (HP:0003071)1.66289727
135Cystic liver disease (HP:0006706)1.63785615
136Insulin-resistant diabetes mellitus (HP:0000831)1.63255754
137Congenital primary aphakia (HP:0007707)1.62119957
138Hypomagnesemia (HP:0002917)1.61592628
139Gait imbalance (HP:0002141)1.60890258
140Nephrogenic diabetes insipidus (HP:0009806)1.56697213
141Tetraparesis (HP:0002273)1.55888951
142Nephronophthisis (HP:0000090)1.55798255
143Abnormality of renal excretion (HP:0011036)1.54407414
144Increased circulating renin level (HP:0000848)1.53360057
145Progressive cerebellar ataxia (HP:0002073)1.53252819
146Lissencephaly (HP:0001339)1.52886217
147True hermaphroditism (HP:0010459)1.50471888
148Type II diabetes mellitus (HP:0005978)1.49785605
149Abnormality of alanine metabolism (HP:0010916)1.49493495
150Hyperalaninemia (HP:0003348)1.49493495
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.49493495
152Decreased electroretinogram (ERG) amplitude (HP:0000654)1.48523745
153Severe muscular hypotonia (HP:0006829)1.48301603
154Molar tooth sign on MRI (HP:0002419)1.48144861
155Abnormality of midbrain morphology (HP:0002418)1.48144861
156Hyperventilation (HP:0002883)1.48054390
157EEG with generalized epileptiform discharges (HP:0011198)1.44858790
158Hypokalemia (HP:0002900)1.42475342
159Hypothermia (HP:0002045)1.41996485
160Hypoplastic labia majora (HP:0000059)1.40467937
161Abnormal spermatogenesis (HP:0008669)1.39999558
162Metabolic alkalosis (HP:0200114)1.39814328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK9.26014627
2LMTK26.29809628
3ERN15.09334072
4EIF2AK34.49814752
5MAP2K24.02790513
6TRIB33.35173053
7EPHA23.09002900
8INSRR3.00525382
9GRK12.88095858
10PKN22.84342437
11FRK2.63757387
12BMPR1B2.52158643
13MAPKAPK32.29961345
14ADRBK22.11033771
15TAOK32.00984839
16NTRK31.88951243
17MAPK151.88223828
18ACVR1B1.87029646
19ZAP701.85197012
20IRAK31.83030793
21MST41.79811615
22MAP2K11.66567831
23SCYL21.59133571
24MAP4K21.59009495
25PAK21.45811891
26WNK41.45674487
27NME11.44710269
28PIK3CG1.41579589
29MAP3K121.36948552
30OXSR11.36559103
31CASK1.34891333
32NLK1.34694427
33WNK31.32838045
34DYRK1A1.25435299
35PTK61.24000915
36RPS6KB21.21087227
37PDGFRB1.13040035
38STK38L1.12307618
39PRKG21.11008038
40FLT31.07355488
41MAP3K21.05267556
42LATS11.04190428
43NME21.03405125
44PIK3CA1.01052629
45EEF2K0.97439320
46MAP3K40.94229274
47SIK10.94010231
48PRKCE0.93974212
49TRPM70.89910188
50PDK20.89394434
51CAMKK10.83430310
52STK160.77471630
53ADRBK10.75549955
54DAPK20.75485601
55DYRK1B0.73703205
56IRAK20.73609561
57MAP2K60.70322353
58RET0.70175887
59PAK30.69942390
60BRSK20.69067000
61STK390.67170344
62MTOR0.66899749
63CAMKK20.65844898
64TLK10.64663107
65MAPK130.64618742
66EPHB10.62289484
67EIF2AK10.61139737
68PRKAA10.60974105
69SGK20.60538112
70TIE10.59326208
71PRKCH0.59320482
72SGK4940.54701521
73SGK2230.54701521
74TNK20.54636355
75FER0.54254266
76BCR0.53561076
77TGFBR10.53375014
78FGFR40.53310022
79PDPK10.52699802
80TTN0.51888547
81PRKCI0.51790674
82RIPK10.51039305
83IRAK40.50719231
84LRRK20.49444148
85CHUK0.49184867
86STK240.49105096
87PRKCQ0.48994342
88PRKCZ0.48918856
89PINK10.48273321
90MUSK0.47879953
91RPS6KB10.45877793
92PRKD30.45432579
93NTRK10.45289597
94EPHA30.44720296
95MAP3K10.44618114
96PRKAA20.44433582
97MAPK120.43977496
98MAP3K70.42714078
99TNIK0.42559192
100MELK0.42154902
101IRAK10.42154760
102ROCK10.41555956
103CSNK1G10.41513014
104NEK60.41105362
105STK380.40857301
106PDK10.40076469
107PDGFRA0.39885407
108KSR20.39796968
109HIPK20.38866314
110PHKG10.38230459
111PHKG20.38230459
112JAK20.38054768
113PTK20.37991085
114ZAK0.37009510
115CSNK1A10.36299294
116PRKCG0.35535405
117ERBB30.35475915
118PDK30.34348686
119PDK40.34348686
120TSSK60.33333132
121NUAK10.33086344
122PRKD10.32740075
123STK30.32692772
124MAP3K30.32573331
125IKBKB0.32124730
126MET0.31970906
127PRKCA0.31262416
128MAPK30.30520736
129TXK0.30353207
130PRKACB0.28570403
131SGK30.28403917
132MAP3K50.27815753
133MKNK20.26404928
134CSNK1G30.24513899
135MAP3K90.24314532
136RPS6KA10.23895319
137ABL10.23232711
138JAK10.22415223
139ILK0.22342383
140TBK10.21877467
141CSNK1D0.21218276
142IGF1R0.21143763
143DDR20.19190849
144FGFR30.18618636
145PASK0.18451738
146MAP2K40.17601208
147CAMK1D0.16771697
148MST1R0.15302464
149GSK3A0.14918619
150MAPK10.14656846
151MAPK110.14369566
152MAPKAPK50.13929293
153MAP2K30.13017020
154EGFR0.11630673
155TYRO30.11595503
156PRKACA0.09780778
157PRKD20.08848426
158AKT10.08529064
159CDC42BPA0.08498084
160RPS6KA30.08430158
161DYRK20.08232184

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049728.41297298
2Fat digestion and absorption_Homo sapiens_hsa049756.16369135
3Protein digestion and absorption_Homo sapiens_hsa049745.57068028
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.41624594
5Protein export_Homo sapiens_hsa030603.31015597
6Glycerolipid metabolism_Homo sapiens_hsa005613.07961925
7Folate biosynthesis_Homo sapiens_hsa007902.68700575
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.48659875
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.29586802
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19659977
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09724495
12Vitamin digestion and absorption_Homo sapiens_hsa049772.01903258
13Steroid biosynthesis_Homo sapiens_hsa001001.84767921
14Propanoate metabolism_Homo sapiens_hsa006401.74025260
15Renin-angiotensin system_Homo sapiens_hsa046141.46869115
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19896081
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16831825
18Linoleic acid metabolism_Homo sapiens_hsa005911.12879483
19Arginine and proline metabolism_Homo sapiens_hsa003301.05019849
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02941638
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01211395
22Starch and sucrose metabolism_Homo sapiens_hsa005001.00620358
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00237560
24N-Glycan biosynthesis_Homo sapiens_hsa005100.88573911
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87762021
26Biosynthesis of amino acids_Homo sapiens_hsa012300.85267517
27Insulin secretion_Homo sapiens_hsa049110.78641986
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77109500
29Selenocompound metabolism_Homo sapiens_hsa004500.76509712
30Influenza A_Homo sapiens_hsa051640.76448763
31Other glycan degradation_Homo sapiens_hsa005110.76177567
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73722345
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69083028
34Circadian rhythm_Homo sapiens_hsa047100.68620270
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68437149
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67654929
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67476752
38Sulfur metabolism_Homo sapiens_hsa009200.66852540
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.66851596
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62800153
41Notch signaling pathway_Homo sapiens_hsa043300.62342065
42Vibrio cholerae infection_Homo sapiens_hsa051100.61417112
43beta-Alanine metabolism_Homo sapiens_hsa004100.60688515
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59224749
45Phototransduction_Homo sapiens_hsa047440.56752261
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56742670
47One carbon pool by folate_Homo sapiens_hsa006700.53658322
48Fatty acid degradation_Homo sapiens_hsa000710.51160480
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.48653680
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48449713
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48125191
52Pyruvate metabolism_Homo sapiens_hsa006200.46127103
53Vitamin B6 metabolism_Homo sapiens_hsa007500.45633505
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45503862
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.43230310
56Mineral absorption_Homo sapiens_hsa049780.42574397
57Arachidonic acid metabolism_Homo sapiens_hsa005900.42062336
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41140521
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40982511
60Retinol metabolism_Homo sapiens_hsa008300.39824097
61Legionellosis_Homo sapiens_hsa051340.39635630
62Tryptophan metabolism_Homo sapiens_hsa003800.38644767
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38277032
64ABC transporters_Homo sapiens_hsa020100.37268523
65Arginine biosynthesis_Homo sapiens_hsa002200.36908953
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31831169
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30942941
68Glutathione metabolism_Homo sapiens_hsa004800.28978592
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.28871705
70Ether lipid metabolism_Homo sapiens_hsa005650.28629371
71Lysosome_Homo sapiens_hsa041420.28566895
72Carbon metabolism_Homo sapiens_hsa012000.26088060
73Metabolic pathways_Homo sapiens_hsa011000.25877136
74Fructose and mannose metabolism_Homo sapiens_hsa000510.25612160
75Endometrial cancer_Homo sapiens_hsa052130.25391344
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24946529
77Peroxisome_Homo sapiens_hsa041460.24573098
78VEGF signaling pathway_Homo sapiens_hsa043700.24431015
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24042189
80Regulation of autophagy_Homo sapiens_hsa041400.23406478
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22770601
82Alzheimers disease_Homo sapiens_hsa050100.22059258
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20789210
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20189908
85Insulin resistance_Homo sapiens_hsa049310.18093240
86Ovarian steroidogenesis_Homo sapiens_hsa049130.16920163
87Calcium signaling pathway_Homo sapiens_hsa040200.16662538
88Histidine metabolism_Homo sapiens_hsa003400.15630759
89Nitrogen metabolism_Homo sapiens_hsa009100.15179767
90Fatty acid metabolism_Homo sapiens_hsa012120.14819059
91Sphingolipid metabolism_Homo sapiens_hsa006000.14776352
92Sulfur relay system_Homo sapiens_hsa041220.13887717
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13481155
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13070424
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12447214
96mTOR signaling pathway_Homo sapiens_hsa041500.11811858
97Salivary secretion_Homo sapiens_hsa049700.11395017
98Parkinsons disease_Homo sapiens_hsa050120.11260420
99Prostate cancer_Homo sapiens_hsa052150.11005814
100Toxoplasmosis_Homo sapiens_hsa051450.09664554
101Oxidative phosphorylation_Homo sapiens_hsa001900.08926976
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.07948407
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07699762
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07657353
105Caffeine metabolism_Homo sapiens_hsa002320.07644681
106Taste transduction_Homo sapiens_hsa047420.06858909
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.06274901
108Insulin signaling pathway_Homo sapiens_hsa049100.05287593
109Chemical carcinogenesis_Homo sapiens_hsa052040.04649398
110Estrogen signaling pathway_Homo sapiens_hsa049150.03934211
111Cocaine addiction_Homo sapiens_hsa050300.03675032
112Thyroid hormone synthesis_Homo sapiens_hsa049180.03464188
113Type I diabetes mellitus_Homo sapiens_hsa049400.03377819
114Gastric acid secretion_Homo sapiens_hsa049710.03118455
115Bile secretion_Homo sapiens_hsa049760.03114629
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.02495817
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.02483226
118Phenylalanine metabolism_Homo sapiens_hsa003600.01963678
119Tight junction_Homo sapiens_hsa045300.01952493
120Butanoate metabolism_Homo sapiens_hsa006500.01830033
121Type II diabetes mellitus_Homo sapiens_hsa049300.01660389
122Non-small cell lung cancer_Homo sapiens_hsa052230.01627939
123AMPK signaling pathway_Homo sapiens_hsa041520.01554502
124Ras signaling pathway_Homo sapiens_hsa040140.00405085
125Hepatitis C_Homo sapiens_hsa05160-0.0730249
126Serotonergic synapse_Homo sapiens_hsa04726-0.0660487
127Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0639516
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321-0.0443581
129Complement and coagulation cascades_Homo sapiens_hsa04610-0.0392975
130Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0380350
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0286858
132RNA polymerase_Homo sapiens_hsa03020-0.0275661
133Nicotine addiction_Homo sapiens_hsa05033-0.0256148
134Tyrosine metabolism_Homo sapiens_hsa00350-0.0246077
135Olfactory transduction_Homo sapiens_hsa04740-0.0200181
136Collecting duct acid secretion_Homo sapiens_hsa04966-0.0116414
137Asthma_Homo sapiens_hsa05310-0.0059745

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