GP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)8.34745311
2protein neddylation (GO:0045116)8.13601792
3neutrophil activation involved in immune response (GO:0002283)6.69028232
4blood coagulation, intrinsic pathway (GO:0007597)5.45942074
5regulation of platelet aggregation (GO:0090330)5.37383567
6regulation of platelet activation (GO:0010543)5.36113992
7negative regulation of thymocyte apoptotic process (GO:0070244)5.22626352
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.15766683
9negative regulation of heart rate (GO:0010459)5.11938889
10leukocyte migration involved in inflammatory response (GO:0002523)5.07550116
11daunorubicin metabolic process (GO:0044597)5.07309455
12polyketide metabolic process (GO:0030638)5.07309455
13doxorubicin metabolic process (GO:0044598)5.07309455
14positive regulation of endothelial cell differentiation (GO:0045603)4.88553901
15regulation of integrin-mediated signaling pathway (GO:2001044)4.80609735
16negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.71240633
17superoxide anion generation (GO:0042554)4.68025553
18platelet aggregation (GO:0070527)4.67518149
19purinergic nucleotide receptor signaling pathway (GO:0035590)4.60373356
20adenosine receptor signaling pathway (GO:0001973)4.46548797
21negative regulation of platelet activation (GO:0010544)4.38005442
22fusion of sperm to egg plasma membrane (GO:0007342)4.29827215
23negative regulation of norepinephrine secretion (GO:0010700)4.26837978
24angiogenesis involved in wound healing (GO:0060055)4.23730712
25negative regulation of appetite (GO:0032099)4.20065548
26negative regulation of response to food (GO:0032096)4.20065548
27positive regulation of cellular amide metabolic process (GO:0034250)4.07578227
28positive regulation of cAMP-mediated signaling (GO:0043950)4.06372893
29low-density lipoprotein particle remodeling (GO:0034374)3.92244055
30regulation of lipoprotein metabolic process (GO:0050746)3.91990278
31lipoxygenase pathway (GO:0019372)3.91426911
32negative regulation of homotypic cell-cell adhesion (GO:0034111)3.89296591
33DNA integration (GO:0015074)3.87561906
34platelet dense granule organization (GO:0060155)3.85163131
35energy homeostasis (GO:0097009)3.77564389
36polyamine biosynthetic process (GO:0006596)3.66650828
37regulation of Golgi to plasma membrane protein transport (GO:0042996)3.64929606
38granulocyte activation (GO:0036230)3.64271191
39autophagic vacuole fusion (GO:0000046)3.62652751
40negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.60369307
41regulation of endothelial cell differentiation (GO:0045601)3.59824789
42regulation of integrin activation (GO:0033623)3.57649787
43megakaryocyte development (GO:0035855)3.57292820
44negative regulation of mast cell activation (GO:0033004)3.54639513
45purinergic receptor signaling pathway (GO:0035587)3.54630646
46response to peptidoglycan (GO:0032494)3.54210503
47pyrimidine dimer repair (GO:0006290)3.53889564
48termination of G-protein coupled receptor signaling pathway (GO:0038032)3.52155801
49negative regulation of protein localization to cell surface (GO:2000009)3.49348081
50regulation of MHC class II biosynthetic process (GO:0045346)3.46538654
51positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.45701007
52platelet formation (GO:0030220)3.39443795
53mitochondrial calcium ion transport (GO:0006851)3.38696610
54regulation of macrophage derived foam cell differentiation (GO:0010743)3.37858716
55microtubule depolymerization (GO:0007019)3.37691016
56dopamine transport (GO:0015872)3.35623658
57termination of signal transduction (GO:0023021)3.34164607
58negative regulation of heart contraction (GO:0045822)3.33030990
59positive regulation of granulocyte differentiation (GO:0030854)3.27606064
60negative regulation of T cell apoptotic process (GO:0070233)3.26010852
61negative regulation of calcium ion transport into cytosol (GO:0010523)3.25777702
62platelet degranulation (GO:0002576)3.25730795
63regulation of memory T cell differentiation (GO:0043380)3.24805745
64phospholipid homeostasis (GO:0055091)3.20119153
65leukocyte degranulation (GO:0043299)3.19204488
66developmental pigmentation (GO:0048066)3.17976817
67homotypic cell-cell adhesion (GO:0034109)3.17898194
68plasma membrane fusion (GO:0045026)3.17891105
69cellular biogenic amine biosynthetic process (GO:0042401)3.17764190
70nucleotide transmembrane transport (GO:1901679)3.17120243
71positive regulation of uterine smooth muscle contraction (GO:0070474)3.16910729
72positive regulation of macrophage differentiation (GO:0045651)3.15942674
73high-density lipoprotein particle remodeling (GO:0034375)3.14790635
74regulation of female receptivity (GO:0045924)3.14437793
75DNA catabolic process, exonucleolytic (GO:0000738)3.13517418
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11938116
77positive regulation of Rho protein signal transduction (GO:0035025)3.08377901
78cellular biogenic amine catabolic process (GO:0042402)3.06497944
79amine catabolic process (GO:0009310)3.06497944
80presynaptic membrane assembly (GO:0097105)3.06122539
81positive regulation of protein homodimerization activity (GO:0090073)3.05502663
82amine biosynthetic process (GO:0009309)3.04941853
83regulation of activation of Janus kinase activity (GO:0010533)3.03162342
84regulation of mitochondrial translation (GO:0070129)3.02261989
85reverse cholesterol transport (GO:0043691)3.01876564
86fatty acid elongation (GO:0030497)3.00552576
87regulation of homotypic cell-cell adhesion (GO:0034110)2.99372878
88* platelet activation (GO:0030168)2.99363309
89pyrimidine nucleoside catabolic process (GO:0046135)2.98773414
90female mating behavior (GO:0060180)2.98581912
91negative regulation of neural precursor cell proliferation (GO:2000178)2.97614940
92positive regulation of systemic arterial blood pressure (GO:0003084)2.96576117
93negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.95812630
94regulation of norepinephrine secretion (GO:0014061)2.94702857
95monoamine transport (GO:0015844)2.93944218
96natural killer cell activation involved in immune response (GO:0002323)2.93817572
97centriole assembly (GO:0098534)2.93281646
98aminoglycoside antibiotic metabolic process (GO:0030647)2.92005818
99positive regulation of hemostasis (GO:1900048)2.91922500
100positive regulation of blood coagulation (GO:0030194)2.91922500
101negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.90710577
102negative regulation of T-helper cell differentiation (GO:0045623)2.90710577
103detection of molecule of bacterial origin (GO:0032490)2.90467879
104organelle membrane fusion (GO:0090174)2.89731866
105phosphatidylinositol acyl-chain remodeling (GO:0036149)2.89332848
106long-chain fatty acid biosynthetic process (GO:0042759)2.88898045
107cytochrome complex assembly (GO:0017004)2.82337866
108beta-amyloid metabolic process (GO:0050435)2.82234614
109presynaptic membrane organization (GO:0097090)2.81216426
110DNA double-strand break processing (GO:0000729)2.80062727
111cellular response to interleukin-15 (GO:0071350)2.79596256
112negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.79545967
113regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.78003130
114regulation of thymocyte apoptotic process (GO:0070243)2.76520950
115hydrogen peroxide biosynthetic process (GO:0050665)2.73283072
116positive regulation of receptor recycling (GO:0001921)2.70006910
117G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.69607475
118negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.68865391
119regulation of regulatory T cell differentiation (GO:0045589)2.67671251
120regulation of fever generation (GO:0031620)2.67069884
121tRNA methylation (GO:0030488)2.66378511
122superoxide metabolic process (GO:0006801)2.64762102
123regulation of cholesterol efflux (GO:0010874)2.64708329
124negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.63397207
125regulation of sensory perception (GO:0051931)2.63241876
126regulation of sensory perception of pain (GO:0051930)2.63241876
127dendritic cell chemotaxis (GO:0002407)2.62636336
128deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.62333755
129negative regulation of telomere maintenance (GO:0032205)2.60390561
130proteasome assembly (GO:0043248)2.57509350
131adenosine metabolic process (GO:0046085)2.56097643
132cellular response to exogenous dsRNA (GO:0071360)2.53630499
133ganglion development (GO:0061548)2.51797641
134regulation of development, heterochronic (GO:0040034)2.50542885
135regulation of mast cell activation (GO:0033003)2.50484521
136DNA synthesis involved in DNA repair (GO:0000731)2.49161320
137positive regulation of defense response to virus by host (GO:0002230)2.47493124
138negative regulation of DNA-dependent DNA replication (GO:2000104)2.47167481
139positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.46397853
140regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.46397853
141cellular response to interferon-beta (GO:0035458)2.45748353
142reactive oxygen species biosynthetic process (GO:1903409)2.45066987
143regulation of timing of cell differentiation (GO:0048505)2.44800842
144histamine secretion (GO:0001821)2.44368340
145mannosylation (GO:0097502)2.44328284
146positive regulation of heat generation (GO:0031652)2.44224370
147replicative senescence (GO:0090399)2.43499523
148regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.42349281
149regulation of mitotic spindle checkpoint (GO:1903504)2.42349281
150auditory receptor cell stereocilium organization (GO:0060088)2.41339167
151leukocyte aggregation (GO:0070486)2.41021160
152neutrophil activation (GO:0042119)2.39950940
153positive regulation of interleukin-1 beta secretion (GO:0050718)2.39517731
154cellular response to superoxide (GO:0071451)2.39504190
155cellular response to oxygen radical (GO:0071450)2.39504190
156removal of superoxide radicals (GO:0019430)2.39504190
157regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38933607
158prostate gland growth (GO:0060736)2.38347124
159regulation of interleukin-8 secretion (GO:2000482)2.37922806
160GPI anchor biosynthetic process (GO:0006506)2.37869983
161mesenchymal cell differentiation involved in kidney development (GO:0072161)2.35512310
162mesenchymal cell differentiation involved in renal system development (GO:2001012)2.35512310
163positive regulation by symbiont of host defense response (GO:0052509)2.34331252
164modulation by symbiont of host defense response (GO:0052031)2.34331252
165modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34331252
166modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.34331252
167positive regulation by organism of defense response of other organism involved in symbiotic interact2.34331252
168modulation by symbiont of host immune response (GO:0052553)2.34331252
169protein complex biogenesis (GO:0070271)2.33933905
170regulation of nuclear cell cycle DNA replication (GO:0033262)2.33798124
171G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.33243053
172negative regulation of T cell mediated immunity (GO:0002710)2.32503060
173opioid receptor signaling pathway (GO:0038003)2.31967395
174positive regulation of protein sumoylation (GO:0033235)2.28732188
175deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.28560130
176pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.27273348
177termination of RNA polymerase III transcription (GO:0006386)2.26960911
178transcription elongation from RNA polymerase III promoter (GO:0006385)2.26960911
179deoxyribonucleotide biosynthetic process (GO:0009263)2.24965306
180regulation of interleukin-6 biosynthetic process (GO:0045408)2.24784915
181dendritic cell migration (GO:0036336)2.22711029
182cell differentiation involved in metanephros development (GO:0072202)2.22475401
183detection of external biotic stimulus (GO:0098581)2.22365448
184sympathetic nervous system development (GO:0048485)2.21675855
185positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.21565149
186startle response (GO:0001964)2.21255852
187positive regulation of mast cell activation involved in immune response (GO:0033008)2.19958678
188positive regulation of mast cell degranulation (GO:0043306)2.19958678
189deoxyribose phosphate biosynthetic process (GO:0046385)2.19519707
1902-deoxyribonucleotide biosynthetic process (GO:0009265)2.19519707
191regulation of uterine smooth muscle contraction (GO:0070472)2.18209875
192DNA deamination (GO:0045006)2.17409374
193respiratory chain complex IV assembly (GO:0008535)2.16940556
194response to superoxide (GO:0000303)2.16697157
195positive regulation of mast cell activation (GO:0033005)2.16660657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.20406852
2GBX2_23144817_ChIP-Seq_PC3_Human3.68684860
3SCL_19346495_ChIP-Seq_HPC-7_Human3.51995161
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.46153086
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06037159
6EZH2_22144423_ChIP-Seq_EOC_Human2.96629392
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.79858701
8GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.72056049
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.61451473
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61255524
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60260087
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55381162
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43654823
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40600109
15LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.39700525
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36548370
17* GATA1_19941826_ChIP-Seq_K562_Human2.30764161
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.28968343
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.25518478
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23413175
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.18601461
22NFE2_27457419_Chip-Seq_LIVER_Mouse2.18077500
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17947703
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15683255
25* GATA2_19941826_ChIP-Seq_K562_Human2.13957530
26IGF1R_20145208_ChIP-Seq_DFB_Human2.11848641
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09255136
28IRF8_22096565_ChIP-ChIP_GC-B_Human2.05854229
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.97642545
30GATA1_19941827_ChIP-Seq_MEL_Mouse1.95526802
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91492646
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90012532
33GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.88575436
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87944774
35HTT_18923047_ChIP-ChIP_STHdh_Human1.87654412
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.87065116
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85243808
38STAT3_18555785_Chip-Seq_ESCs_Mouse1.83205848
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.83074999
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.81744818
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.81441301
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.80682009
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.79867310
44NMYC_18555785_Chip-Seq_ESCs_Mouse1.79199199
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.77278670
46P53_22387025_ChIP-Seq_ESCs_Mouse1.75291509
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.73524284
48IRF1_19129219_ChIP-ChIP_H3396_Human1.73162508
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72420665
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.72380268
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70560364
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.70264895
53RUNX1_27457419_Chip-Seq_LIVER_Mouse1.69510428
54* SPI1_23127762_ChIP-Seq_K562_Human1.68690557
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68459862
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65744632
57P300_18555785_Chip-Seq_ESCs_Mouse1.63622276
58ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62625923
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.62233450
60P300_19829295_ChIP-Seq_ESCs_Human1.61575884
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.58802261
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57250127
63ZFX_18555785_Chip-Seq_ESCs_Mouse1.55889326
64* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55866813
65SOX2_18555785_Chip-Seq_ESCs_Mouse1.55031614
66FUS_26573619_Chip-Seq_HEK293_Human1.53870592
67OCT4_18555785_Chip-Seq_ESCs_Mouse1.53765647
68SMAD1_18555785_Chip-Seq_ESCs_Mouse1.53589236
69KLF4_18555785_Chip-Seq_ESCs_Mouse1.53499042
70RNF2_27304074_Chip-Seq_NSC_Mouse1.52743291
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51580253
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50920152
73PU1_27457419_Chip-Seq_LIVER_Mouse1.47930764
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43299947
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42535240
76ESRRB_18555785_Chip-Seq_ESCs_Mouse1.42307895
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.42179701
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35406131
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34841317
80TAF15_26573619_Chip-Seq_HEK293_Human1.34638074
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34073241
82GATA1_22025678_ChIP-Seq_K562_Human1.32734740
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32684242
84SALL4_22934838_ChIP-ChIP_CD34+_Human1.31620797
85CTCF_18555785_Chip-Seq_ESCs_Mouse1.31558812
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.31502768
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29555554
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27723702
89NANOG_19829295_ChIP-Seq_ESCs_Human1.27571739
90SOX2_19829295_ChIP-Seq_ESCs_Human1.27571739
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26931958
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24964670
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.24660816
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23990135
95ER_23166858_ChIP-Seq_MCF-7_Human1.23718066
96BCAT_22108803_ChIP-Seq_LS180_Human1.22603210
97* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22395208
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.22011009
99EED_16625203_ChIP-ChIP_MESCs_Mouse1.20994801
100EZH2_27304074_Chip-Seq_ESCs_Mouse1.20655431
101FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20423399
102KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20133461
103RUNX_20019798_ChIP-Seq_JUKART_Human1.19649125
104VDR_22108803_ChIP-Seq_LS180_Human1.19556182
105IRF8_27001747_Chip-Seq_BMDM_Mouse1.18684550
106AR_25329375_ChIP-Seq_VCAP_Human1.17342555
107GATA3_26560356_Chip-Seq_TH2_Human1.16220745
108EWS_26573619_Chip-Seq_HEK293_Human1.15642602
109GABP_17652178_ChIP-ChIP_JURKAT_Human1.15551597
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15386273
111* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.15229507
112EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14239901
113TP53_22573176_ChIP-Seq_HFKS_Human1.12710861
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12703561
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11797915
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11301520
117STAT3_23295773_ChIP-Seq_U87_Human1.10879844
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10590300
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10393183
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10380865
121EST1_17652178_ChIP-ChIP_JURKAT_Human1.09597361
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08543790
123FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07782957
124FOXA1_25329375_ChIP-Seq_VCAP_Human1.07782957
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.06128643
126RUNX1_22412390_ChIP-Seq_EML_Mouse1.05825844
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05672963
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05672963
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04426234
130SMAD4_21799915_ChIP-Seq_A2780_Human1.04164476
131CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03809515
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03203101
133* NANOG_20526341_ChIP-Seq_ESCs_Human1.01691970
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01542175
135SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01011300
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00013915
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99238602
138AR_20517297_ChIP-Seq_VCAP_Human0.98866509
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98580799
140FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98507420
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98397715
142NOTCH1_21737748_ChIP-Seq_TLL_Human0.98235432
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98227084
144* TCF4_23295773_ChIP-Seq_U87_Human0.97513996
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.97267026
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96864364
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95612961
148OCT1_27270436_Chip-Seq_PROSTATE_Human0.94503557
149GATA3_27048872_Chip-Seq_THYMUS_Human0.94138859
150ELK1_19687146_ChIP-ChIP_HELA_Human0.93655214
151RUNX2_22187159_ChIP-Seq_PCA_Human0.93329490
152ERG_20517297_ChIP-Seq_VCAP_Human0.93064142
153CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92634735
154STAT1_20625510_ChIP-Seq_HELA_Human0.92143901
155FLI1_21867929_ChIP-Seq_TH2_Mouse0.91777788
156UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91659356
157* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91469678
158SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91333055
159SPI1_20517297_ChIP-Seq_HL60_Human0.91096861
160ETS1_22383799_ChIP-Seq_G1ME_Mouse0.89834588
161* SMRT_27268052_Chip-Seq_Bcells_Human0.89743730
162RBPJ_21746931_ChIP-Seq_IB4_Human0.89634811
163TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88260018
164POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88260018
165KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86483421
166KDM2B_26808549_Chip-Seq_REH_Human0.86161363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005464_abnormal_platelet_physiology8.58520433
2MP0006292_abnormal_olfactory_placode4.23749964
3MP0000566_synostosis3.65954232
4MP0003136_yellow_coat_color3.41946830
5MP0001188_hyperpigmentation3.41903527
6MP0005171_absent_coat_pigmentation3.29255239
7MP0000465_gastrointestinal_hemorrhage3.00248503
8MP0002277_abnormal_respiratory_mucosa2.93763907
9MP0004381_abnormal_hair_follicle2.51070638
10MP0009697_abnormal_copulation2.46532961
11MP0002638_abnormal_pupillary_reflex2.45579427
12MP0000015_abnormal_ear_pigmentation2.40611603
13MP0005410_abnormal_fertilization2.36186531
14MP0000372_irregular_coat_pigmentation2.33456619
15MP0005083_abnormal_biliary_tract2.32802351
16MP0004084_abnormal_cardiac_muscle2.31792827
17MP0000230_abnormal_systemic_arterial2.28121865
18MP0002132_abnormal_respiratory_system2.26109973
19MP0001986_abnormal_taste_sensitivity2.25374023
20MP0001968_abnormal_touch/_nociception2.21065369
21MP0008775_abnormal_heart_ventricle2.16322419
22MP0009785_altered_susceptibility_to2.15624259
23MP0008872_abnormal_physiological_respon2.09709588
24MP0004510_myositis2.09331100
25MP0003724_increased_susceptibility_to2.09098775
26MP0005084_abnormal_gallbladder_morpholo2.00191970
27MP0005646_abnormal_pituitary_gland1.97211128
28MP0005645_abnormal_hypothalamus_physiol1.95284278
29MP0010386_abnormal_urinary_bladder1.94022429
30MP0005167_abnormal_blood-brain_barrier1.93536872
31MP0003787_abnormal_imprinting1.93221150
32MP0001835_abnormal_antigen_presentation1.89031303
33MP0005671_abnormal_response_to1.79819627
34MP0008058_abnormal_DNA_repair1.79372205
35MP0000343_altered_response_to1.78604255
36MP0002148_abnormal_hypersensitivity_rea1.77378048
37MP0002163_abnormal_gland_morphology1.77239492
38MP0005379_endocrine/exocrine_gland_phen1.73296811
39MP0003638_abnormal_response/metabolism_1.67028866
40MP0002102_abnormal_ear_morphology1.65174310
41MP0005409_darkened_coat_color1.64508320
42MP0008789_abnormal_olfactory_epithelium1.58684863
43MP0002733_abnormal_thermal_nociception1.54022453
44MP0005174_abnormal_tail_pigmentation1.50673430
45MP0003941_abnormal_skin_development1.49676444
46MP0002938_white_spotting1.48724982
47MP0006276_abnormal_autonomic_nervous1.44203337
48MP0004036_abnormal_muscle_relaxation1.44070696
49MP0004782_abnormal_surfactant_physiolog1.42934389
50MP0004742_abnormal_vestibular_system1.42068024
51MP0001346_abnormal_lacrimal_gland1.41422489
52MP0004130_abnormal_muscle_cell1.39009178
53MP0003879_abnormal_hair_cell1.38943532
54MP0005075_abnormal_melanosome_morpholog1.36854548
55MP0003303_peritoneal_inflammation1.35551229
56MP0010155_abnormal_intestine_physiology1.34498963
57MP0003828_pulmonary_edema1.32450534
58MP0002398_abnormal_bone_marrow1.31171150
59MP0002419_abnormal_innate_immunity1.30191149
60MP0002095_abnormal_skin_pigmentation1.28852789
61MP0004142_abnormal_muscle_tone1.28243310
62MP0001529_abnormal_vocalization1.28034399
63MP0005025_abnormal_response_to1.25504419
64MP0001970_abnormal_pain_threshold1.25445447
65MP0008877_abnormal_DNA_methylation1.24871873
66MP0002876_abnormal_thyroid_physiology1.24328145
67MP0001879_abnormal_lymphatic_vessel1.23761064
68MP0001790_abnormal_immune_system1.23294928
69MP0005387_immune_system_phenotype1.23294928
70MP0001545_abnormal_hematopoietic_system1.23288579
71MP0005397_hematopoietic_system_phenotyp1.23288579
72MP0001663_abnormal_digestive_system1.22123932
73MP0001984_abnormal_olfaction1.21860579
74MP0004215_abnormal_myocardial_fiber1.21442159
75MP0002653_abnormal_ependyma_morphology1.20266691
76MP0001485_abnormal_pinna_reflex1.19636938
77MP0005000_abnormal_immune_tolerance1.17191895
78MP0008007_abnormal_cellular_replicative1.15404753
79MP0005551_abnormal_eye_electrophysiolog1.15238916
80MP0008057_abnormal_DNA_replication1.15040331
81MP0005394_taste/olfaction_phenotype1.14838491
82MP0005499_abnormal_olfactory_system1.14838491
83MP0010329_abnormal_lipoprotein_level1.14718257
84MP0003718_maternal_effect1.13517452
85MP0002751_abnormal_autonomic_nervous1.13036304
86MP0001186_pigmentation_phenotype1.12707375
87MP0001851_eye_inflammation1.10992317
88MP0003878_abnormal_ear_physiology1.07670544
89MP0005377_hearing/vestibular/ear_phenot1.07670544
90MP0000249_abnormal_blood_vessel1.06530435
91MP0009763_increased_sensitivity_to1.06057968
92MP0006036_abnormal_mitochondrial_physio1.05946682
93MP0000026_abnormal_inner_ear1.04033314
94MP0004484_altered_response_of1.03773905
95MP0003121_genomic_imprinting1.02198597
96MP0000689_abnormal_spleen_morphology1.02111837
97MP0003866_abnormal_defecation1.01879387
98MP0008004_abnormal_stomach_pH1.01331355
99MP0002452_abnormal_antigen_presenting1.00972769
100MP0003566_abnormal_cell_adhesion1.00744791
101MP0002723_abnormal_immune_serum1.00546988
102MP0003656_abnormal_erythrocyte_physiolo1.00383772
103MP0005408_hypopigmentation0.99261740
104MP0008875_abnormal_xenobiotic_pharmacok0.98620310
105MP0009765_abnormal_xenobiotic_induced0.98453234
106MP0001800_abnormal_humoral_immune0.98340424
107MP0001905_abnormal_dopamine_level0.96442744
108MP0003763_abnormal_thymus_physiology0.95884804
109MP0002098_abnormal_vibrissa_morphology0.95519338
110MP0000681_abnormal_thyroid_gland0.94420353
111MP0006035_abnormal_mitochondrial_morpho0.94093618
112MP0001819_abnormal_immune_cell0.92442914
113MP0000613_abnormal_salivary_gland0.92364437
114MP0002420_abnormal_adaptive_immunity0.92248991
115MP0001486_abnormal_startle_reflex0.91926162
116MP0001765_abnormal_ion_homeostasis0.91388742
117MP0009764_decreased_sensitivity_to0.89643110
118MP0005423_abnormal_somatic_nervous0.88889932
119* MP0002429_abnormal_blood_cell0.87035864
120* MP0009642_abnormal_blood_homeostasis0.86861730
121MP0001502_abnormal_circadian_rhythm0.86771083
122MP0001919_abnormal_reproductive_system0.86165097
123MP0002722_abnormal_immune_system0.83795274
124MP0003011_delayed_dark_adaptation0.82458847
125MP0004947_skin_inflammation0.82367403
126MP0003880_abnormal_central_pattern0.82161123
127MP0003693_abnormal_embryo_hatching0.82042214
128MP0004147_increased_porphyrin_level0.81895204
129MP0002138_abnormal_hepatobiliary_system0.81788149
130MP0002557_abnormal_social/conspecific_i0.81728668
131MP0001963_abnormal_hearing_physiology0.80931788
132MP0005058_abnormal_lysosome_morphology0.79908940
133MP0002735_abnormal_chemical_nociception0.79569082
134MP0000383_abnormal_hair_follicle0.79420263
135MP0005389_reproductive_system_phenotype0.79286171
136MP0005535_abnormal_body_temperature0.78666063
137MP0001845_abnormal_inflammatory_respons0.76685700
138MP0001664_abnormal_digestion0.76067537
139MP0003786_premature_aging0.75978080
140MP0008874_decreased_physiological_sensi0.75633414
141MP0000716_abnormal_immune_system0.75624752
142MP0004085_abnormal_heartbeat0.74830659
143MP0003111_abnormal_nucleus_morphology0.74335077
144MP0001501_abnormal_sleep_pattern0.74197591
145MP0000685_abnormal_immune_system0.72400605
146MP0002736_abnormal_nociception_after0.71842187
147MP0001756_abnormal_urination0.71722233
148MP0003186_abnormal_redox_activity0.71697845
149MP0006054_spinal_hemorrhage0.71151985
150MP0000358_abnormal_cell_content/0.70445565
151MP0003698_abnormal_male_reproductive0.69540405
152MP0008260_abnormal_autophagy0.69368471
153MP0001533_abnormal_skeleton_physiology0.69232744
154MP0005310_abnormal_salivary_gland0.69144738
155MP0003436_decreased_susceptibility_to0.68926541
156MP0000569_abnormal_digit_pigmentation0.68809352
157MP0010094_abnormal_chromosome_stability0.68592832
158MP0002075_abnormal_coat/hair_pigmentati0.68355030
159MP0000049_abnormal_middle_ear0.68313740
160MP0004043_abnormal_pH_regulation0.67902053
161MP0008995_early_reproductive_senescence0.67896635
162MP0002177_abnormal_outer_ear0.67843463
163MP0009333_abnormal_splenocyte_physiolog0.67051865
164MP0009046_muscle_twitch0.66824628
165MP0001119_abnormal_female_reproductive0.66257422
166MP0000678_abnormal_parathyroid_gland0.65609977
167MP0001544_abnormal_cardiovascular_syste0.65074486
168MP0005385_cardiovascular_system_phenoty0.65074486
169MP0005381_digestive/alimentary_phenotyp0.64036386

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.83184435
2* Prolonged bleeding time (HP:0003010)9.63805449
3Abnormal platelet volume (HP:0011876)9.21094038
4Petechiae (HP:0000967)9.00392206
5* Menorrhagia (HP:0000132)8.08714533
6Purpura (HP:0000979)8.08590092
7* Epistaxis (HP:0000421)6.38553027
8Gingival bleeding (HP:0000225)5.96903791
9Hyperlipoproteinemia (HP:0010980)5.75673727
10Abnormal platelet function (HP:0011869)4.99382946
11Impaired platelet aggregation (HP:0003540)4.99382946
12Chromosomal breakage induced by crosslinking agents (HP:0003221)4.62975450
13Poikilocytosis (HP:0004447)4.40869364
14Dyschromatopsia (HP:0007641)4.09633716
15Chromsome breakage (HP:0040012)4.04931688
16Acanthocytosis (HP:0001927)3.97387916
17Spontaneous hematomas (HP:0007420)3.48473486
18Duplicated collecting system (HP:0000081)3.34176550
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.30724749
20Abnormality of the renal collecting system (HP:0004742)3.30252273
21Abnormal pupillary function (HP:0007686)3.28291194
22Conjunctival telangiectasia (HP:0000524)3.19936087
23Type I transferrin isoform profile (HP:0003642)3.19124280
24Hypoplasia of the fovea (HP:0007750)3.18946938
25Aplasia/Hypoplasia of the fovea (HP:0008060)3.18946938
26Parakeratosis (HP:0001036)3.18037287
27Abnormality of the common coagulation pathway (HP:0010990)2.94490949
28Paralysis (HP:0003470)2.91080180
29Abnormality of lateral ventricle (HP:0030047)2.89334035
30Congenital sensorineural hearing impairment (HP:0008527)2.82641967
31Abnormal hair whorl (HP:0010721)2.79289038
32Hypothermia (HP:0002045)2.78276015
33Osteomalacia (HP:0002749)2.76842216
34Recurrent abscess formation (HP:0002722)2.76584828
35Prostate neoplasm (HP:0100787)2.76055617
36Abnormality of the vasculature of the conjunctiva (HP:0008054)2.73328450
37Stomach cancer (HP:0012126)2.67879687
38Microvesicular hepatic steatosis (HP:0001414)2.66148925
39Septo-optic dysplasia (HP:0100842)2.66095983
40Increased density of long bones (HP:0006392)2.53109330
41Retrobulbar optic neuritis (HP:0100654)2.51832740
42Optic neuritis (HP:0100653)2.51832740
43Tinnitus (HP:0000360)2.46769219
44* Bruising susceptibility (HP:0000978)2.45996090
45Cheilitis (HP:0100825)2.44927916
46True hermaphroditism (HP:0010459)2.44389034
47Pancreatic fibrosis (HP:0100732)2.41585111
48Thyroid-stimulating hormone excess (HP:0002925)2.39667870
49Abnormality of the preputium (HP:0100587)2.39633185
50Abnormality of the fovea (HP:0000493)2.38653945
51Dry hair (HP:0011359)2.37898640
52Febrile seizures (HP:0002373)2.37316221
53Upper limb muscle weakness (HP:0003484)2.33644215
54White forelock (HP:0002211)2.33302641
55Medial flaring of the eyebrow (HP:0010747)2.30541375
56Abnormal auditory evoked potentials (HP:0006958)2.30019250
57Increased IgM level (HP:0003496)2.29855201
58Generalized aminoaciduria (HP:0002909)2.28971264
59Absent eyebrow (HP:0002223)2.27118195
60Clubbing of toes (HP:0100760)2.23785651
61Ectopic kidney (HP:0000086)2.22663866
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21860147
63Abnormality of alanine metabolism (HP:0010916)2.21860147
64Hyperalaninemia (HP:0003348)2.21860147
65Abnormality of the ileum (HP:0001549)2.21260007
66Meckel diverticulum (HP:0002245)2.20773128
67Reduced antithrombin III activity (HP:0001976)2.20577913
68Abnormality of transition element cation homeostasis (HP:0011030)2.19587317
69Patchy hypopigmentation of hair (HP:0011365)2.19388820
70Hyperthyroidism (HP:0000836)2.18510814
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.17427681
72Chronic mucocutaneous candidiasis (HP:0002728)2.17197408
73Recurrent cutaneous fungal infections (HP:0011370)2.17197408
74Abnormality of iron homeostasis (HP:0011031)2.17005062
75Eczematoid dermatitis (HP:0000976)2.16710779
76Abnormal protein glycosylation (HP:0012346)2.15032165
77Abnormal glycosylation (HP:0012345)2.15032165
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15032165
79Abnormal protein N-linked glycosylation (HP:0012347)2.15032165
80Optic nerve hypoplasia (HP:0000609)2.14514401
81Mediastinal lymphadenopathy (HP:0100721)2.12880435
82Joint swelling (HP:0001386)2.11847514
83Recurrent bacterial skin infections (HP:0005406)2.11394750
84Abnormality of DNA repair (HP:0003254)2.09329734
85Conical tooth (HP:0000698)2.07394784
86Recurrent pneumonia (HP:0006532)2.07319226
87Nephrogenic diabetes insipidus (HP:0009806)2.07254125
88Prolonged neonatal jaundice (HP:0006579)2.07048180
89Abnormality of the renal cortex (HP:0011035)2.06718589
90Pancreatic cysts (HP:0001737)2.05185120
91Abnormality of incisor morphology (HP:0011063)2.04452034
92Nausea (HP:0002018)2.03430919
93Male infertility (HP:0003251)2.02564339
94Renal cortical cysts (HP:0000803)2.02033427
95Alveolar cell carcinoma (HP:0006519)2.01864450
96Polyphagia (HP:0002591)2.01351990
973-Methylglutaconic aciduria (HP:0003535)2.01115375
98Obstructive lung disease (HP:0006536)1.99941079
99Chronic obstructive pulmonary disease (HP:0006510)1.99941079
100Congenital stationary night blindness (HP:0007642)1.98269196
101Xanthomatosis (HP:0000991)1.97799397
102Dynein arm defect of respiratory motile cilia (HP:0012255)1.97496591
103Absent/shortened dynein arms (HP:0200106)1.97496591
104Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96973545
105Absent septum pellucidum (HP:0001331)1.96089708
106Encephalitis (HP:0002383)1.95346348
107Spontaneous abortion (HP:0005268)1.93964744
108Abnormality of the prostate (HP:0008775)1.92691317
109Severe combined immunodeficiency (HP:0004430)1.92389424
110Median cleft lip (HP:0000161)1.92386526
111Preaxial hand polydactyly (HP:0001177)1.91428053
112Decreased central vision (HP:0007663)1.90764213
113Abnormality of chromosome stability (HP:0003220)1.90245650
114Renal dysplasia (HP:0000110)1.89598540
115Abnormality of the septum pellucidum (HP:0007375)1.89598297
116Aplasia cutis congenita (HP:0001057)1.89367590
117Gingivitis (HP:0000230)1.86707287
118Abnormal ciliary motility (HP:0012262)1.85005207
119Hepatosplenomegaly (HP:0001433)1.84323116
120Chronic hepatic failure (HP:0100626)1.83936471
121Renal Fanconi syndrome (HP:0001994)1.82893089
122Tongue fasciculations (HP:0001308)1.81580264
123Abnormal respiratory motile cilium physiology (HP:0012261)1.80906713
124Abolished electroretinogram (ERG) (HP:0000550)1.79142834
125Congenital primary aphakia (HP:0007707)1.77914826
126Episodic fever (HP:0001954)1.76300777
127Ventricular fibrillation (HP:0001663)1.75275054
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74651969
129Type 2 muscle fiber atrophy (HP:0003554)1.74389796
130Aganglionic megacolon (HP:0002251)1.74008195
131Abnormality of dental color (HP:0011073)1.73814234
132Joint hemorrhage (HP:0005261)1.73567794
133Attenuation of retinal blood vessels (HP:0007843)1.72876274
134Renal tubular dysfunction (HP:0000124)1.72485127
135Abnormality of renal resorption (HP:0011038)1.71415314
136Gait imbalance (HP:0002141)1.71102037
137Neoplasm of the tracheobronchial system (HP:0100552)1.71086101
138Dysautonomia (HP:0002459)1.70260101
139Hypergonadotropic hypogonadism (HP:0000815)1.68730427
140Duplication of thumb phalanx (HP:0009942)1.68204283
141Abnormality of macrophages (HP:0004311)1.67967318
142Male pseudohermaphroditism (HP:0000037)1.67189187
143Recurrent corneal erosions (HP:0000495)1.67040276
144Increased serum ferritin (HP:0003281)1.67008036
145Triphalangeal thumb (HP:0001199)1.66864848
146Tubulointerstitial nephritis (HP:0001970)1.66567320
147Infertility (HP:0000789)1.66550615
148Aplasia/Hypoplasia of the macula (HP:0008059)1.66455330
149Orchitis (HP:0100796)1.65580769
150Stomatitis (HP:0010280)1.65292954
151Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.65076566
152Nephronophthisis (HP:0000090)1.64818192
153Intestinal atresia (HP:0011100)1.64556849
154Basal ganglia calcification (HP:0002135)1.64392447
155Arterial thrombosis (HP:0004420)1.64275956
156Oligohydramnios (HP:0001562)1.64170051
157Abnormal respiratory motile cilium morphology (HP:0005938)1.63861103
158Abnormal respiratory epithelium morphology (HP:0012253)1.63861103
159Arthropathy (HP:0003040)1.62989409
160Muscle fibrillation (HP:0010546)1.62872989
161Small intestinal stenosis (HP:0012848)1.62389042
162Elevated erythrocyte sedimentation rate (HP:0003565)1.60958045
163Papillary thyroid carcinoma (HP:0002895)1.60621345
164Exertional dyspnea (HP:0002875)1.57909553
165Hypophosphatemic rickets (HP:0004912)1.57658248
166Molar tooth sign on MRI (HP:0002419)1.57387805
167Abnormality of midbrain morphology (HP:0002418)1.57387805
168Autoimmune hemolytic anemia (HP:0001890)1.56053242
169Abnormal spermatogenesis (HP:0008669)1.55978063
170Central scotoma (HP:0000603)1.54290313
171Hypomagnesemia (HP:0002917)1.53397167
172Biliary tract neoplasm (HP:0100574)1.51310293
173Vertigo (HP:0002321)1.50755573
174Abnormal drinking behavior (HP:0030082)1.50103258
175Polydipsia (HP:0001959)1.50103258
176Intellectual disability, profound (HP:0002187)1.44685051
177Leukocytosis (HP:0001974)1.39620728
178Delayed puberty (HP:0000823)1.39123431
179Acute necrotizing encephalopathy (HP:0006965)1.36942577
180Lissencephaly (HP:0001339)1.35948898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMX3.35550065
2IRAK33.10227993
3IRAK43.01155976
4MYLK2.84979176
5TNIK2.81761080
6TAOK32.81296493
7CASK2.76472886
8ZAK2.73880363
9STK162.68226977
10PTK2B2.67942045
11MAP3K142.66188225
12PBK2.61081147
13MKNK22.53672132
14SIK32.50401507
15TXK2.25853432
16PIK3CG2.18825050
17PRPF4B2.17512864
18GRK51.96960750
19EIF2AK21.93762013
20YES11.93049474
21FRK1.89471015
22BMPR21.88226162
23MAP4K21.76706802
24CDK191.71965227
25CSF1R1.71031014
26VRK11.70224166
27SRPK11.66637445
28MKNK11.66430041
29AKT31.65892575
30GRK61.65429141
31ACVR1B1.63900487
32IRAK11.63376172
33PLK41.62298445
34IRAK21.62014197
35MAP2K71.61831567
36ADRBK21.60794821
37IKBKE1.56627928
38NUAK11.56163705
39NEK61.55645046
40STK31.52975655
41BMPR1B1.51858047
42TRIM281.50047756
43MAPKAPK31.47419056
44RIPK41.44524232
45ZAP701.35973900
46TLK11.33868972
47ILK1.30186716
48HCK1.24408197
49MAPK131.22121717
50TEC1.20541496
51IKBKB1.19902699
52BLK1.18094754
53FGR1.16130956
54WNK41.11759466
55CDK81.11247926
56GRK11.09599642
57DAPK21.08567060
58STK38L1.08006331
59ITK1.07587869
60ADRBK11.05763480
61SGK21.04992074
62BUB11.03354764
63MST41.02011194
64PAK10.98922735
65MATK0.98819195
66INSRR0.94828257
67CDK30.94274964
68PIM20.88590979
69ERBB20.88281594
70TIE10.86961035
71EIF2AK30.85790488
72EIF2AK10.85599977
73PAK30.84772692
74MAP3K120.83547558
75PNCK0.82272915
76GRK70.81360369
77RPS6KA40.80181742
78EPHA20.80023836
79STK240.78633652
80NLK0.76926619
81CHUK0.76805712
82PKN10.76250319
83DAPK30.74896996
84BRD40.74481871
85EPHA30.72993686
86FER0.71492807
87BRAF0.69159288
88MUSK0.66265640
89JAK30.66052533
90NME10.65496546
91STK390.65428820
92TNK20.65217129
93ERBB30.64985491
94PLK30.63485893
95PDK10.61565448
96PRKCE0.60896379
97MARK10.59149674
98SGK2230.57960038
99SGK4940.57960038
100CAMKK20.57757474
101LYN0.56533149
102PLK20.54383774
103BCR0.53686585
104PRKACG0.53160307
105CLK10.52806272
106DYRK20.52565357
107TRPM70.52264615
108MAPK150.51155163
109STK40.50640812
110WNK30.50592838
111PRKD10.50190283
112MINK10.50158784
113MAP3K50.48494629
114ATR0.47300416
115KIT0.46317022
116PRKCQ0.45750163
117TYK20.45599039
118JAK10.45095019
119LMTK20.44320410
120RPS6KA50.43800288
121MARK30.42674245
122TBK10.42575936
123PRKG10.41507199
124BRSK20.41336900
125CSK0.41004721
126DAPK10.40619770
127MAP2K10.40547696
128OXSR10.40429588
129TSSK60.40350615
130MAP2K30.38950155
131MAP3K130.38856784
132PRKCA0.37671134
133SYK0.36852317
134PRKCG0.36505405
135MAPKAPK50.35747448
136CHEK20.35151509
137MAPK120.34750950
138MAPK70.34511701
139CSNK2A10.34353097
140PRKCB0.33952609
141RET0.33574375
142CAMK10.33573647
143BTK0.33089712
144IGF1R0.32558108
145PINK10.31542794
146PDPK10.31371556
147TTK0.30687030
148PRKCD0.30282720
149CAMK2A0.30278757
150JAK20.29551057
151MAPK110.29545197
152LCK0.29041732
153SGK30.28240676
154PRKACA0.27495808
155FES0.26710691
156MAP4K10.26659632
157MAP2K60.26123804
158DYRK1A0.26095784
159NTRK30.25996011
160FYN0.24644637

Predicted pathways (KEGG)

RankGene SetZ-score
1* Platelet activation_Homo sapiens_hsa046114.99490090
2Nitrogen metabolism_Homo sapiens_hsa009103.15757609
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.10314597
4Graft-versus-host disease_Homo sapiens_hsa053323.01475922
5Fanconi anemia pathway_Homo sapiens_hsa034602.50882767
6Homologous recombination_Homo sapiens_hsa034402.28343003
7Allograft rejection_Homo sapiens_hsa053302.02524503
8Proteasome_Homo sapiens_hsa030501.99738824
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95203187
10Basal transcription factors_Homo sapiens_hsa030221.89303851
11Olfactory transduction_Homo sapiens_hsa047401.87088249
12RNA polymerase_Homo sapiens_hsa030201.86716000
13Protein export_Homo sapiens_hsa030601.85994611
14Autoimmune thyroid disease_Homo sapiens_hsa053201.80975396
15Type I diabetes mellitus_Homo sapiens_hsa049401.79606542
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.76923567
17Primary immunodeficiency_Homo sapiens_hsa053401.75823527
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75696248
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.73512617
20Measles_Homo sapiens_hsa051621.67417787
21Rheumatoid arthritis_Homo sapiens_hsa053231.64461485
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64456321
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.62639181
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60068727
25Oxidative phosphorylation_Homo sapiens_hsa001901.59175326
26Hematopoietic cell lineage_Homo sapiens_hsa046401.55812518
27Nicotine addiction_Homo sapiens_hsa050331.55002321
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51019499
29Gap junction_Homo sapiens_hsa045401.50154479
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41896011
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40973507
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40677515
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39827847
34Glycerolipid metabolism_Homo sapiens_hsa005611.39710896
35Mismatch repair_Homo sapiens_hsa034301.39373185
36Herpes simplex infection_Homo sapiens_hsa051681.32372447
37Pyrimidine metabolism_Homo sapiens_hsa002401.30776622
38Nucleotide excision repair_Homo sapiens_hsa034201.30420146
39Leishmaniasis_Homo sapiens_hsa051401.27625984
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26830908
41African trypanosomiasis_Homo sapiens_hsa051431.26136915
42Sulfur metabolism_Homo sapiens_hsa009201.24566095
43Ribosome_Homo sapiens_hsa030101.21433427
44DNA replication_Homo sapiens_hsa030301.21356932
45Legionellosis_Homo sapiens_hsa051341.20427306
46Base excision repair_Homo sapiens_hsa034101.19826078
47Long-term depression_Homo sapiens_hsa047301.19019787
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16889560
49Alcoholism_Homo sapiens_hsa050341.15987973
50Systemic lupus erythematosus_Homo sapiens_hsa053221.15713294
51Pancreatic secretion_Homo sapiens_hsa049721.15303139
52* ECM-receptor interaction_Homo sapiens_hsa045121.13076168
53Arachidonic acid metabolism_Homo sapiens_hsa005901.12776762
54Circadian entrainment_Homo sapiens_hsa047131.12246241
55Influenza A_Homo sapiens_hsa051641.08945528
56Sphingolipid metabolism_Homo sapiens_hsa006001.08635630
57Fatty acid elongation_Homo sapiens_hsa000621.08446705
58Non-homologous end-joining_Homo sapiens_hsa034501.07936766
59Asthma_Homo sapiens_hsa053101.04478012
60Huntingtons disease_Homo sapiens_hsa050161.01616718
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01357994
62Phototransduction_Homo sapiens_hsa047441.01336568
63Collecting duct acid secretion_Homo sapiens_hsa049661.00486901
64Parkinsons disease_Homo sapiens_hsa050120.98161855
65Fat digestion and absorption_Homo sapiens_hsa049750.97875104
66Endocytosis_Homo sapiens_hsa041440.97603058
67Purine metabolism_Homo sapiens_hsa002300.96650474
68Calcium signaling pathway_Homo sapiens_hsa040200.90809013
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90361431
70B cell receptor signaling pathway_Homo sapiens_hsa046620.90108700
71Taste transduction_Homo sapiens_hsa047420.90108344
72Serotonergic synapse_Homo sapiens_hsa047260.89088352
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88572762
74Malaria_Homo sapiens_hsa051440.87381582
75Shigellosis_Homo sapiens_hsa051310.86868944
76Phagosome_Homo sapiens_hsa041450.86284740
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.85747565
78Ether lipid metabolism_Homo sapiens_hsa005650.84083159
79Pertussis_Homo sapiens_hsa051330.83948103
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83323905
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82698090
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82052394
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80764263
84Alzheimers disease_Homo sapiens_hsa050100.80423767
85Glutathione metabolism_Homo sapiens_hsa004800.80250164
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79520152
87Spliceosome_Homo sapiens_hsa030400.78987191
88RNA degradation_Homo sapiens_hsa030180.78546962
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.78235887
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75541523
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.74883454
92TNF signaling pathway_Homo sapiens_hsa046680.73752715
93Other glycan degradation_Homo sapiens_hsa005110.73209811
94Vitamin digestion and absorption_Homo sapiens_hsa049770.72358328
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71838133
96Morphine addiction_Homo sapiens_hsa050320.71501240
97Tuberculosis_Homo sapiens_hsa051520.70833958
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70628692
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70460670
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70446341
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68939010
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67854664
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.67397339
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66575314
105Chemical carcinogenesis_Homo sapiens_hsa052040.65800136
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.65034029
107Regulation of autophagy_Homo sapiens_hsa041400.64831115
108Glutamatergic synapse_Homo sapiens_hsa047240.64693505
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63049104
110ABC transporters_Homo sapiens_hsa020100.61009962
111Linoleic acid metabolism_Homo sapiens_hsa005910.59408600
112Choline metabolism in cancer_Homo sapiens_hsa052310.57366571
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57210317
114Staphylococcus aureus infection_Homo sapiens_hsa051500.57143884
115Steroid biosynthesis_Homo sapiens_hsa001000.55813455
116One carbon pool by folate_Homo sapiens_hsa006700.55272157
117Mineral absorption_Homo sapiens_hsa049780.54839439
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53052244
119Cholinergic synapse_Homo sapiens_hsa047250.52075895
120Epstein-Barr virus infection_Homo sapiens_hsa051690.51907973
121Ras signaling pathway_Homo sapiens_hsa040140.51557254
122Hepatitis C_Homo sapiens_hsa051600.50995113
123Salmonella infection_Homo sapiens_hsa051320.50955297
124beta-Alanine metabolism_Homo sapiens_hsa004100.49535242
125Osteoclast differentiation_Homo sapiens_hsa043800.48270563
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48204698
127Caffeine metabolism_Homo sapiens_hsa002320.47762266
128Rap1 signaling pathway_Homo sapiens_hsa040150.47149143
129p53 signaling pathway_Homo sapiens_hsa041150.46308437
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.45063081
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44647447
132Salivary secretion_Homo sapiens_hsa049700.44182917
133Chemokine signaling pathway_Homo sapiens_hsa040620.44109959
134Oxytocin signaling pathway_Homo sapiens_hsa049210.41244976
135Ovarian steroidogenesis_Homo sapiens_hsa049130.40954146
136T cell receptor signaling pathway_Homo sapiens_hsa046600.40406921
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.39611274
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39556197
139Starch and sucrose metabolism_Homo sapiens_hsa005000.37196878
140Apoptosis_Homo sapiens_hsa042100.36745517
141Gastric acid secretion_Homo sapiens_hsa049710.36624941
142GABAergic synapse_Homo sapiens_hsa047270.36528927
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36519834
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36142791
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35683054
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35592317
147Renin-angiotensin system_Homo sapiens_hsa046140.34952451
148Fatty acid biosynthesis_Homo sapiens_hsa000610.34919872
149Antigen processing and presentation_Homo sapiens_hsa046120.33917299
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33078033
151Vibrio cholerae infection_Homo sapiens_hsa051100.31736425

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