GP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)7.91927414
2ribosomal small subunit assembly (GO:0000028)7.79728438
3regulation of platelet aggregation (GO:0090330)6.09329734
4definitive hemopoiesis (GO:0060216)6.02351853
5viral transcription (GO:0019083)6.00698430
6protein neddylation (GO:0045116)5.77614501
7translational termination (GO:0006415)5.74165819
8leukocyte migration involved in inflammatory response (GO:0002523)5.67213553
9regulation of platelet activation (GO:0010543)5.50670951
10negative regulation of thymocyte apoptotic process (GO:0070244)5.23229390
11platelet aggregation (GO:0070527)5.21604589
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.20956149
13platelet dense granule organization (GO:0060155)5.12901739
14cotranslational protein targeting to membrane (GO:0006613)5.08607687
15translational elongation (GO:0006414)5.07510453
16protein targeting to ER (GO:0045047)5.06037592
17DNA strand elongation involved in DNA replication (GO:0006271)5.03795887
18ribosomal small subunit biogenesis (GO:0042274)5.02496152
19adenosine receptor signaling pathway (GO:0001973)4.99944817
20positive regulation of mast cell activation (GO:0033005)4.98439994
21neutrophil activation (GO:0042119)4.96673815
22telomere maintenance via semi-conservative replication (GO:0032201)4.90445487
23DNA strand elongation (GO:0022616)4.88755479
24megakaryocyte development (GO:0035855)4.88580410
25protein localization to endoplasmic reticulum (GO:0070972)4.83543564
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.83021406
27DNA deamination (GO:0045006)4.82085777
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.79281983
29lipoxygenase pathway (GO:0019372)4.77833014
30negative regulation of homotypic cell-cell adhesion (GO:0034111)4.73771557
31maturation of SSU-rRNA (GO:0030490)4.68759385
32positive regulation of endothelial cell differentiation (GO:0045603)4.54038047
33viral life cycle (GO:0019058)4.52061499
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.50227016
35DNA replication initiation (GO:0006270)4.45141779
36granulocyte activation (GO:0036230)4.38194010
37angiogenesis involved in wound healing (GO:0060055)4.38100636
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.35516336
39cellular protein complex disassembly (GO:0043624)4.32873364
40negative regulation of platelet activation (GO:0010544)4.24337590
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24164645
42negative regulation of norepinephrine secretion (GO:0010700)4.15094578
43thrombin receptor signaling pathway (GO:0070493)4.14212904
44regulation of integrin-mediated signaling pathway (GO:2001044)4.13066268
45DNA unwinding involved in DNA replication (GO:0006268)4.08397928
46telomere maintenance via recombination (GO:0000722)4.05226958
47response to interferon-beta (GO:0035456)4.04782405
48negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.01939659
49translational initiation (GO:0006413)4.01021561
50protein complex disassembly (GO:0043241)3.83823441
51regulation of integrin activation (GO:0033623)3.83816538
52homotypic cell-cell adhesion (GO:0034109)3.83571068
53negative regulation of heart rate (GO:0010459)3.83467109
54mitotic recombination (GO:0006312)3.82174259
55positive regulation of macrophage differentiation (GO:0045651)3.81207662
56purinergic nucleotide receptor signaling pathway (GO:0035590)3.80925113
57platelet degranulation (GO:0002576)3.80488913
58negative regulation of erythrocyte differentiation (GO:0045647)3.67144241
59regulation of MHC class II biosynthetic process (GO:0045346)3.67010866
60regulation of homotypic cell-cell adhesion (GO:0034110)3.63156347
61platelet formation (GO:0030220)3.62379056
62heparin biosynthetic process (GO:0030210)3.61864909
63heparin metabolic process (GO:0030202)3.61864909
64regulation of mast cell degranulation (GO:0043304)3.61762892
65antigen processing and presentation via MHC class Ib (GO:0002475)3.60352386
66positive regulation of cAMP-mediated signaling (GO:0043950)3.60289452
67negative regulation of T cell apoptotic process (GO:0070233)3.59100181
68leukocyte degranulation (GO:0043299)3.58953787
69macromolecular complex disassembly (GO:0032984)3.58595659
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57858017
71antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57858017
72regulation of mast cell activation (GO:0033003)3.57321372
73nuclear-transcribed mRNA catabolic process (GO:0000956)3.56638779
74endosome to pigment granule transport (GO:0043485)3.56558650
75endosome to melanosome transport (GO:0035646)3.56558650
76polyamine biosynthetic process (GO:0006596)3.53727634
77positive regulation of B cell differentiation (GO:0045579)3.53262871
78telomere maintenance via telomere lengthening (GO:0010833)3.52657025
79* platelet activation (GO:0030168)3.46444033
80low-density lipoprotein particle remodeling (GO:0034374)3.45065989
81regulation of mast cell activation involved in immune response (GO:0033006)3.42441085
82secretory granule organization (GO:0033363)3.42305238
83purinergic receptor signaling pathway (GO:0035587)3.40925982
84positive regulation of Rho protein signal transduction (GO:0035025)3.40676234
85purine-containing compound salvage (GO:0043101)3.40063740
86mRNA catabolic process (GO:0006402)3.39796345
87positive regulation of blood coagulation (GO:0030194)3.36072419
88positive regulation of hemostasis (GO:1900048)3.36072419
89negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.35631897
90G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.34879858
91protein targeting to membrane (GO:0006612)3.30799242
92mature B cell differentiation involved in immune response (GO:0002313)3.28945162
93CENP-A containing nucleosome assembly (GO:0034080)3.27525239
94positive regulation of mast cell activation involved in immune response (GO:0033008)3.27248186
95positive regulation of mast cell degranulation (GO:0043306)3.27248186
96regulation of lipoprotein metabolic process (GO:0050746)3.26462459
97regulation of erythrocyte differentiation (GO:0045646)3.25742413
98response to interferon-alpha (GO:0035455)3.25240577
99fusion of sperm to egg plasma membrane (GO:0007342)3.21624180
100RNA catabolic process (GO:0006401)3.21584234
101nucleotide-excision repair, DNA gap filling (GO:0006297)3.21044137
102embryonic hemopoiesis (GO:0035162)3.20435434
103regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.17941616
104positive regulation of receptor recycling (GO:0001921)3.17639483
105negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.17480530
106* blood coagulation, intrinsic pathway (GO:0007597)3.15908484
107regulation of Golgi to plasma membrane protein transport (GO:0042996)3.14464430
108negative regulation of stress fiber assembly (GO:0051497)3.13938234
109regulation of macrophage derived foam cell differentiation (GO:0010743)3.13144711
110termination of signal transduction (GO:0023021)3.11903586
111erythrocyte maturation (GO:0043249)3.11644529
112termination of G-protein coupled receptor signaling pathway (GO:0038032)3.08697120
113positive regulation of systemic arterial blood pressure (GO:0003084)3.07830043
114Arp2/3 complex-mediated actin nucleation (GO:0034314)3.07002017
115myeloid cell activation involved in immune response (GO:0002275)3.06459670
116heme biosynthetic process (GO:0006783)3.05840605
117negative regulation of neural precursor cell proliferation (GO:2000178)3.02696375
118positive regulation of coagulation (GO:0050820)3.01066347
119negative regulation of response to food (GO:0032096)3.00612051
120negative regulation of appetite (GO:0032099)3.00612051
121negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00099625
122negative regulation of T-helper cell differentiation (GO:0045623)3.00099625
123regulation of endothelial cell differentiation (GO:0045601)2.99487165
124translation (GO:0006412)2.98699207
125positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.98123895
126chromatin remodeling at centromere (GO:0031055)2.97338682
127pyrimidine nucleoside catabolic process (GO:0046135)2.96768405
128pseudouridine synthesis (GO:0001522)2.96436963
129ribosomal large subunit biogenesis (GO:0042273)2.96225685
130histamine transport (GO:0051608)2.95054157
131regulation of thymocyte apoptotic process (GO:0070243)2.94505347
132positive regulation of gamma-delta T cell activation (GO:0046645)2.93505904
133mitochondrial calcium ion transport (GO:0006851)2.92757832
134autophagic vacuole fusion (GO:0000046)2.92141654
135negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.91223668
136phagocytosis, engulfment (GO:0006911)2.91162068
137regulation of myeloid leukocyte mediated immunity (GO:0002886)2.90746708
138DNA replication checkpoint (GO:0000076)2.90209193
139negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89861624
140negative regulation of cell killing (GO:0031342)2.89861624
141metallo-sulfur cluster assembly (GO:0031163)2.88880474
142iron-sulfur cluster assembly (GO:0016226)2.88880474
143beta-amyloid metabolic process (GO:0050435)2.88201972
144negative regulation of protein localization to cell surface (GO:2000009)2.87277284
145negative regulation of calcium ion transport into cytosol (GO:0010523)2.87202923
146regulation of norepinephrine secretion (GO:0014061)2.86952902
147positive regulation of granulocyte differentiation (GO:0030854)2.86532939
148myeloid cell development (GO:0061515)2.85349171
149extracellular fibril organization (GO:0043206)2.83326792
150antigen processing and presentation of endogenous antigen (GO:0019883)2.82629448
151negative regulation of viral entry into host cell (GO:0046597)2.82622434
152regulation of leukocyte degranulation (GO:0043300)2.81593459
153positive regulation of respiratory burst (GO:0060267)2.80068254
154superoxide anion generation (GO:0042554)2.80028883
155regulation of regulatory T cell differentiation (GO:0045589)2.78971703
156regulation of cholesterol efflux (GO:0010874)2.78342239
157positive regulation of immunoglobulin mediated immune response (GO:0002891)2.77328450
158positive regulation of B cell mediated immunity (GO:0002714)2.77328450
159vesicle targeting (GO:0006903)2.76492315
160DNA replication-independent nucleosome organization (GO:0034724)2.76280168
161DNA replication-independent nucleosome assembly (GO:0006336)2.76280168
162negative regulation of heart contraction (GO:0045822)2.75505431
163ribonucleoprotein complex biogenesis (GO:0022613)2.75177386
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74762537
165necroptotic process (GO:0070266)2.72583456
166positive regulation of cellular amide metabolic process (GO:0034250)2.72184220
167microglial cell activation (GO:0001774)2.71915888
168T cell homeostasis (GO:0043029)2.69938396
169negative regulation of viral genome replication (GO:0045071)2.69293270
170oxygen transport (GO:0015671)2.67761603
171protoporphyrinogen IX metabolic process (GO:0046501)2.67732797
172actin filament polymerization (GO:0030041)2.67399506
173IMP biosynthetic process (GO:0006188)2.67320576
174regulation of blood coagulation (GO:0030193)2.65543730
175L-fucose catabolic process (GO:0042355)2.65154811
176fucose catabolic process (GO:0019317)2.65154811
177L-fucose metabolic process (GO:0042354)2.65154811
178daunorubicin metabolic process (GO:0044597)2.64400753
179polyketide metabolic process (GO:0030638)2.64400753
180doxorubicin metabolic process (GO:0044598)2.64400753
181protein localization to kinetochore (GO:0034501)2.63186990
182G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.62282038
183mast cell activation (GO:0045576)2.61921702
184meiotic chromosome segregation (GO:0045132)2.61136984
185positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57452186
186regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.56488613
187IMP metabolic process (GO:0046040)2.56336995
188histone mRNA metabolic process (GO:0008334)2.56173068
189telomere organization (GO:0032200)2.55347334
190telomere maintenance (GO:0000723)2.54338212
191heme metabolic process (GO:0042168)2.53876246
192mucosal-associated lymphoid tissue development (GO:0048537)2.53495750
193Peyers patch development (GO:0048541)2.53495750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.51019105
2SCL_19346495_ChIP-Seq_HPC-7_Human4.64089699
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.57704007
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92851358
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.21979319
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06728927
7GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.06655513
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.97314584
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89509543
10* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.88074617
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72026278
12* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.71226688
13GATA1_22025678_ChIP-Seq_K562_Human2.70354559
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.65080756
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60375535
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55916087
17* GATA2_19941826_ChIP-Seq_K562_Human2.53556275
18* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.49239781
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45224595
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.31634765
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.30136492
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.26085601
23SRY_22984422_ChIP-ChIP_TESTIS_Rat2.24725493
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23783739
25GATA2_21666600_ChIP-Seq_HMVEC_Human2.21519443
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.19927575
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18440791
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14759307
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14380934
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13693677
31HOXB4_20404135_ChIP-ChIP_EML_Mouse2.12331932
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10857547
33MYC_22102868_ChIP-Seq_BL_Human2.10305882
34ERG_20887958_ChIP-Seq_HPC-7_Mouse2.08028686
35VDR_21846776_ChIP-Seq_THP-1_Human2.01325047
36GABP_17652178_ChIP-ChIP_JURKAT_Human2.00694307
37* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.97014741
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.90995528
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90843057
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88533477
41* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.87576839
42VDR_23849224_ChIP-Seq_CD4+_Human1.87218810
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86769346
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86647420
45SPI1_23547873_ChIP-Seq_NB4_Human1.85438617
46RUNX_20019798_ChIP-Seq_JUKART_Human1.84819137
47XRN2_22483619_ChIP-Seq_HELA_Human1.84682458
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.81737398
49* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.81386217
50FOXP3_21729870_ChIP-Seq_TREG_Human1.80911224
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78816507
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.76136347
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.72343344
54ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71203369
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71097501
56* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69257557
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.69064330
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65337303
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61490272
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60974409
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58521600
62* RUNX1_22412390_ChIP-Seq_EML_Mouse1.56724020
63GATA1_19941827_ChIP-Seq_MEL86_Mouse1.55387233
64* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.55364175
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54938826
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50872740
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.50025548
68CIITA_25753668_ChIP-Seq_RAJI_Human1.49020888
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48723097
70* GATA1_19941827_ChIP-Seq_MEL_Mouse1.48683993
71* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43641157
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.43586460
73VDR_24763502_ChIP-Seq_THP-1_Human1.43343148
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41901307
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.40980094
76GABP_19822575_ChIP-Seq_HepG2_Human1.38827922
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37557925
78ELK1_19687146_ChIP-ChIP_HELA_Human1.37249453
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37137093
80DCP1A_22483619_ChIP-Seq_HELA_Human1.36422924
81NCOR1_26117541_ChIP-Seq_K562_Human1.33948024
82EZH2_22144423_ChIP-Seq_EOC_Human1.32824343
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32326974
84TTF2_22483619_ChIP-Seq_HELA_Human1.30238657
85* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29687317
86SPI1_20517297_ChIP-Seq_HL60_Human1.29029999
87MAF_26560356_Chip-Seq_TH1_Human1.27719289
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27627265
89STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27609030
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27277807
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27087395
92HTT_18923047_ChIP-ChIP_STHdh_Human1.26971828
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26398103
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26315874
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25617452
96MYB_26560356_Chip-Seq_TH2_Human1.23857723
97KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22971229
98UTX_26944678_Chip-Seq_JUKART_Human1.22343207
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20311331
100MYB_26560356_Chip-Seq_TH1_Human1.19930639
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19304547
102GATA3_27048872_Chip-Seq_THYMUS_Human1.18804884
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18191875
104* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17293795
105EGR1_19374776_ChIP-ChIP_THP-1_Human1.17019181
106TCF7_22412390_ChIP-Seq_EML_Mouse1.16538084
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15158339
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12007231
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11212321
110BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08880722
111IRF8_21731497_ChIP-ChIP_J774_Mouse1.07090452
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06781318
113ETS1_22383799_ChIP-Seq_G1ME_Mouse1.06497894
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06062085
115CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05662833
116AR_21909140_ChIP-Seq_LNCAP_Human1.04205984
117SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01461868
118GATA1_19941826_ChIP-Seq_K562_Human1.01293198
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01075235
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00607207
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99086862
122PU_27001747_Chip-Seq_BMDM_Mouse0.98440653
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97884776
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97071885
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96817650
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95797434
127GATA3_26560356_Chip-Seq_TH2_Human0.95476316
128GBX2_23144817_ChIP-Seq_PC3_Human0.94029225
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93172734
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93078773
131E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92913794
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92904771
133ELK3_25401928_ChIP-Seq_HUVEC_Human0.92712828
134THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92622853
135MYC_18940864_ChIP-ChIP_HL60_Human0.92548609
136RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91920368
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89664045
138HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88817587
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87884717
140PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87235550
141MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87147042
142CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86280947
143PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86076055
144SPI1_23127762_ChIP-Seq_K562_Human0.86055461
145STAT1_20625510_ChIP-Seq_HELA_Human0.85836703
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85773449
147SALL4_22934838_ChIP-ChIP_CD34+_Human0.85146284
148RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83451246
149CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83442013
150VDR_24787735_ChIP-Seq_THP-1_Human0.83399276
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82386792
152BCL6_27268052_Chip-Seq_Bcells_Human0.81147055
153NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78600836
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78600836
155HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77736819
156BCOR_27268052_Chip-Seq_Bcells_Human0.77387334
157CTCF_21964334_ChIP-Seq_BJAB-B_Human0.74206124
158SMRT_27268052_Chip-Seq_Bcells_Human0.73121054
159CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71885594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH4.70042180
2MP0002396_abnormal_hematopoietic_system4.25463982
3MP0005464_abnormal_platelet_physiology4.09310582
4MP0004147_increased_porphyrin_level4.03116631
5MP0004808_abnormal_hematopoietic_stem3.40092059
6MP0000465_gastrointestinal_hemorrhage3.32121081
7MP0003303_peritoneal_inflammation3.08253220
8MP0006054_spinal_hemorrhage3.05934496
9MP0003656_abnormal_erythrocyte_physiolo3.02161288
10MP0010094_abnormal_chromosome_stability2.94504820
11MP0004510_myositis2.93487538
12MP0001545_abnormal_hematopoietic_system2.63435266
13MP0005397_hematopoietic_system_phenotyp2.63435266
14MP0001835_abnormal_antigen_presentation2.48032493
15MP0003724_increased_susceptibility_to2.46301890
16MP0005671_abnormal_response_to2.28150324
17MP0005174_abnormal_tail_pigmentation2.25752323
18MP0000490_abnormal_crypts_of2.19721166
19MP0003693_abnormal_embryo_hatching2.19142076
20MP0002398_abnormal_bone_marrow2.17181815
21MP0003191_abnormal_cellular_cholesterol2.13054046
22MP0008058_abnormal_DNA_repair2.12806291
23MP0005075_abnormal_melanosome_morpholog2.12756311
24MP0009785_altered_susceptibility_to2.10074100
25MP0009379_abnormal_foot_pigmentation2.06753260
26MP0000685_abnormal_immune_system2.02224467
27MP0003763_abnormal_thymus_physiology1.94392935
28MP0003111_abnormal_nucleus_morphology1.94334182
29MP0003077_abnormal_cell_cycle1.94021876
30MP0000689_abnormal_spleen_morphology1.89149065
31MP0008057_abnormal_DNA_replication1.87447050
32MP0001851_eye_inflammation1.84528383
33MP0002722_abnormal_immune_system1.83689871
34MP0002095_abnormal_skin_pigmentation1.83127793
35MP0008007_abnormal_cellular_replicative1.78430180
36MP0006036_abnormal_mitochondrial_physio1.75319991
37MP0002429_abnormal_blood_cell1.74965210
38MP0003300_gastrointestinal_ulcer1.70512912
39MP0005025_abnormal_response_to1.68347378
40MP0000230_abnormal_systemic_arterial1.64814504
41MP0001800_abnormal_humoral_immune1.63633732
42MP0001853_heart_inflammation1.62733211
43MP0002148_abnormal_hypersensitivity_rea1.61254346
44MP0004947_skin_inflammation1.61047055
45MP0004957_abnormal_blastocyst_morpholog1.60398573
46MP0002420_abnormal_adaptive_immunity1.59643081
47MP0001533_abnormal_skeleton_physiology1.58906211
48MP0001819_abnormal_immune_cell1.57377464
49MP0002452_abnormal_antigen_presenting1.57044170
50MP0009333_abnormal_splenocyte_physiolog1.56941775
51MP0000716_abnormal_immune_system1.56546651
52MP0003866_abnormal_defecation1.55669380
53MP0002736_abnormal_nociception_after1.54947607
54MP0002723_abnormal_immune_serum1.54840300
55MP0004084_abnormal_cardiac_muscle1.52035365
56MP0003943_abnormal_hepatobiliary_system1.45914153
57MP0003879_abnormal_hair_cell1.45456740
58MP0005000_abnormal_immune_tolerance1.44957964
59MP0010155_abnormal_intestine_physiology1.44029248
60MP0001663_abnormal_digestive_system1.39501408
61MP0004130_abnormal_muscle_cell1.38392042
62MP0000343_altered_response_to1.36637566
63MP0009697_abnormal_copulation1.33509867
64MP0010368_abnormal_lymphatic_system1.30780997
65MP0000858_altered_metastatic_potential1.30481986
66MP0002877_abnormal_melanocyte_morpholog1.28675435
67MP0002166_altered_tumor_susceptibility1.28597647
68MP0002419_abnormal_innate_immunity1.27662546
69MP0000249_abnormal_blood_vessel1.24939110
70MP0001873_stomach_inflammation1.24822486
71MP0000703_abnormal_thymus_morphology1.24193739
72MP0003436_decreased_susceptibility_to1.23227367
73MP0002019_abnormal_tumor_incidence1.22369638
74MP0008775_abnormal_heart_ventricle1.21338663
75MP0003186_abnormal_redox_activity1.20491868
76MP0004036_abnormal_muscle_relaxation1.17007829
77MP0000313_abnormal_cell_death1.15807259
78MP0005410_abnormal_fertilization1.15160272
79MP0008872_abnormal_physiological_respon1.13381007
80MP0002405_respiratory_system_inflammati1.13174709
81MP0003567_abnormal_fetal_cardiomyocyte1.10525183
82MP0009278_abnormal_bone_marrow1.06399294
83MP0008469_abnormal_protein_level1.05073728
84MP0000015_abnormal_ear_pigmentation1.04236695
85MP0001968_abnormal_touch/_nociception1.03475578
86MP0001845_abnormal_inflammatory_respons1.03351819
87MP0006292_abnormal_olfactory_placode1.01047491
88MP0002998_abnormal_bone_remodeling0.99969026
89MP0008874_decreased_physiological_sensi0.99900876
90MP0001790_abnormal_immune_system0.98904503
91MP0005387_immune_system_phenotype0.98904503
92MP0006082_CNS_inflammation0.98891276
93MP0005083_abnormal_biliary_tract0.97253275
94MP0002006_tumorigenesis0.96474746
95MP0001986_abnormal_taste_sensitivity0.96343225
96MP0003075_altered_response_to0.95804785
97MP0001879_abnormal_lymphatic_vessel0.94571120
98MP0008260_abnormal_autophagy0.93002079
99MP0002733_abnormal_thermal_nociception0.92831810
100MP0008877_abnormal_DNA_methylation0.92824149
101MP0002132_abnormal_respiratory_system0.89832785
102MP0009642_abnormal_blood_homeostasis0.88557819
103MP0010329_abnormal_lipoprotein_level0.87120606
104MP0005381_digestive/alimentary_phenotyp0.85958648
105MP0003172_abnormal_lysosome_physiology0.83839451
106MP0000598_abnormal_liver_morphology0.80273195
107MP0009765_abnormal_xenobiotic_induced0.78645865
108MP0005165_increased_susceptibility_to0.78547516
109MP0001764_abnormal_homeostasis0.77975319
110MP0005058_abnormal_lysosome_morphology0.77946667
111MP0003183_abnormal_peptide_metabolism0.76511961
112MP0004883_abnormal_blood_vessel0.76302699
113MP0009763_increased_sensitivity_to0.73160927
114MP0005646_abnormal_pituitary_gland0.72771734
115MP0005535_abnormal_body_temperature0.71642347
116MP0003453_abnormal_keratinocyte_physiol0.71445592
117MP0000350_abnormal_cell_proliferation0.70744412
118MP0003828_pulmonary_edema0.70057976
119MP0005310_abnormal_salivary_gland0.69807425
120MP0003221_abnormal_cardiomyocyte_apopto0.69804985
121MP0005084_abnormal_gallbladder_morpholo0.69408172
122MP0005167_abnormal_blood-brain_barrier0.69003274
123MP0001915_intracranial_hemorrhage0.68942430
124MP0001765_abnormal_ion_homeostasis0.68521734
125MP0003566_abnormal_cell_adhesion0.67738126
126MP0004484_altered_response_of0.67522129
127MP0008932_abnormal_embryonic_tissue0.67381668
128MP0003868_abnormal_feces_composition0.67115846
129MP0005023_abnormal_wound_healing0.66446894
130MP0002653_abnormal_ependyma_morphology0.65390586
131MP0003638_abnormal_response/metabolism_0.65378844
132MP0005409_darkened_coat_color0.65223344
133MP0001970_abnormal_pain_threshold0.64618542
134MP0000477_abnormal_intestine_morphology0.64385487
135MP0009764_decreased_sensitivity_to0.63822509
136MP0003795_abnormal_bone_structure0.63153920
137MP0001544_abnormal_cardiovascular_syste0.60900224
138MP0005385_cardiovascular_system_phenoty0.60900224
139MP0008873_increased_physiological_sensi0.60870408
140MP0001348_abnormal_lacrimal_gland0.60230881
141MP0002128_abnormal_blood_circulation0.60034626
142MP0003786_premature_aging0.58904571
143MP0002118_abnormal_lipid_homeostasis0.57844152

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)7.03900476
2* Prolonged bleeding time (HP:0003010)6.31400581
3Abnormal number of erythroid precursors (HP:0012131)6.19656299
4Abnormality of cells of the erythroid lineage (HP:0012130)6.08081619
5Abnormality of the heme biosynthetic pathway (HP:0010472)6.01938301
6Hyperlipoproteinemia (HP:0010980)5.78923065
7Aplastic anemia (HP:0001915)5.08841443
8Impaired platelet aggregation (HP:0003540)5.01291851
9Abnormal platelet function (HP:0011869)5.01291851
10Thrombocytosis (HP:0001894)4.94323962
11Reticulocytopenia (HP:0001896)4.76086384
12* Purpura (HP:0000979)4.58956657
13* Epistaxis (HP:0000421)4.23421476
14IgM deficiency (HP:0002850)4.12379363
15Chronic otitis media (HP:0000389)3.92176375
16Pallor (HP:0000980)3.72363209
17Gingival bleeding (HP:0000225)3.69909367
18Abnormality of macrophages (HP:0004311)3.66832417
19Stomatitis (HP:0010280)3.61692299
20Conjunctival telangiectasia (HP:0000524)3.58555338
21Muscle fiber atrophy (HP:0100295)3.49028692
22* Abnormal platelet volume (HP:0011876)3.47488050
23Type 2 muscle fiber atrophy (HP:0003554)3.46023295
24* Menorrhagia (HP:0000132)3.33548794
25Abnormality of the common coagulation pathway (HP:0010990)3.30699017
26Increased density of long bones (HP:0006392)3.27719931
27Dyschromatopsia (HP:0007641)3.23476132
28Macrocytic anemia (HP:0001972)3.18421160
29Abnormality of the vasculature of the conjunctiva (HP:0008054)3.16917714
30* Increased mean platelet volume (HP:0011877)3.13814265
31Poikilocytosis (HP:0004447)3.11997618
32Type I transferrin isoform profile (HP:0003642)3.11411147
33Obstructive lung disease (HP:0006536)3.09751002
34Chronic obstructive pulmonary disease (HP:0006510)3.09751002
35Eczematoid dermatitis (HP:0000976)3.05398871
36Abnormal pupillary function (HP:0007686)3.04169782
37Amaurosis fugax (HP:0100576)2.91247947
38Hepatosplenomegaly (HP:0001433)2.91144843
39Elevated erythrocyte sedimentation rate (HP:0003565)2.84432451
40Increased IgM level (HP:0003496)2.81860176
41Paralysis (HP:0003470)2.79238504
42Microcytic anemia (HP:0001935)2.78581660
43Reduced antithrombin III activity (HP:0001976)2.77125380
44Myelodysplasia (HP:0002863)2.75386432
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.73057759
46Abnormality of the prostate (HP:0008775)2.72368836
47Encephalitis (HP:0002383)2.69633243
48Papilledema (HP:0001085)2.62725844
49Pancytopenia (HP:0001876)2.58749900
50Recurrent viral infections (HP:0004429)2.55802891
51Episodic fever (HP:0001954)2.55291652
5211 pairs of ribs (HP:0000878)2.54360945
53Abnormality of T cell physiology (HP:0011840)2.54330308
54Hepatocellular necrosis (HP:0001404)2.49468486
55Abnormality of reticulocytes (HP:0004312)2.47938564
56Myositis (HP:0100614)2.46007760
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45106190
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43353585
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43353585
60Recurrent abscess formation (HP:0002722)2.41954126
61Joint swelling (HP:0001386)2.41684309
62Hyperthyroidism (HP:0000836)2.41388079
63Polycythemia (HP:0001901)2.40041532
64Abnormal glycosylation (HP:0012345)2.39358192
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39358192
66Abnormal protein N-linked glycosylation (HP:0012347)2.39358192
67Abnormal protein glycosylation (HP:0012346)2.39358192
68Increased intramyocellular lipid droplets (HP:0012240)2.37243471
69Bruising susceptibility (HP:0000978)2.35058756
70Colon cancer (HP:0003003)2.34475967
71Recurrent bacterial skin infections (HP:0005406)2.33991398
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32611475
73Hepatic necrosis (HP:0002605)2.32079739
74Cellulitis (HP:0100658)2.32053266
75Ventricular fibrillation (HP:0001663)2.31094634
76Hypochromic microcytic anemia (HP:0004840)2.30606830
77Xanthomatosis (HP:0000991)2.28077635
78Panhypogammaglobulinemia (HP:0003139)2.27928553
79Asplenia (HP:0001746)2.26861993
80Oral leukoplakia (HP:0002745)2.23973267
81Increased serum ferritin (HP:0003281)2.22787924
82Lymphoma (HP:0002665)2.19600247
83Increased cerebral lipofuscin (HP:0011813)2.19375842
84Joint hemorrhage (HP:0005261)2.18072701
85Abnormality of transition element cation homeostasis (HP:0011030)2.16687924
86Arterial thrombosis (HP:0004420)2.16442596
87Birth length less than 3rd percentile (HP:0003561)2.15289237
88Abnormal delayed hypersensitivity skin test (HP:0002963)2.15211613
89Acanthocytosis (HP:0001927)2.13079598
90Recurrent bronchitis (HP:0002837)2.10641407
91Tinnitus (HP:0000360)2.08789705
92Increased muscle lipid content (HP:0009058)2.06322463
93Abnormality of lateral ventricle (HP:0030047)2.03711008
94Microvesicular hepatic steatosis (HP:0001414)2.03449528
95Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.02787369
96Albinism (HP:0001022)2.02533697
97Agnosia (HP:0010524)2.00283787
98Chest pain (HP:0100749)2.00062298
99Acute myeloid leukemia (HP:0004808)1.99994699
100Basal cell carcinoma (HP:0002671)1.99099574
101Aplasia/Hypoplasia of the spleen (HP:0010451)1.97941315
102Gastrointestinal inflammation (HP:0004386)1.97238748
103Intestinal atresia (HP:0011100)1.95976941
104Dysautonomia (HP:0002459)1.92404878
105Hyperbilirubinemia (HP:0002904)1.89576051
106Leukocytosis (HP:0001974)1.88745535
107Vertigo (HP:0002321)1.87605067
108Decreased central vision (HP:0007663)1.87459863
109Migraine (HP:0002076)1.86352850
110Abnormal auditory evoked potentials (HP:0006958)1.86138309
111Exertional dyspnea (HP:0002875)1.85636381
112Neutropenia (HP:0001875)1.84935420
113Abnormality of T cells (HP:0002843)1.84589873
114Diplopia (HP:0000651)1.84247589
115Abnormality of binocular vision (HP:0011514)1.84247589
116Bone marrow hypocellularity (HP:0005528)1.83672007
117Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83530944
118Nausea (HP:0002018)1.82530677
119Abnormality of the nasal mucosa (HP:0000433)1.82084001
120Poikiloderma (HP:0001029)1.81681409
121Erythema (HP:0010783)1.81388752
122Agammaglobulinemia (HP:0004432)1.80291488
123Increased hepatocellular lipid droplets (HP:0006565)1.79793651
124IgG deficiency (HP:0004315)1.78225327
125Inflammation of the large intestine (HP:0002037)1.77533502
126Acute lymphatic leukemia (HP:0006721)1.77467550
127Hypochromic anemia (HP:0001931)1.76934147
128Microretrognathia (HP:0000308)1.76223208
129Male infertility (HP:0003251)1.76197562
130Granulocytopenia (HP:0001913)1.75319000
131Myocardial infarction (HP:0001658)1.74995532
132Upper limb muscle weakness (HP:0003484)1.74815750
133Nonprogressive disorder (HP:0003680)1.74001149
134Congenital, generalized hypertrichosis (HP:0004540)1.71621167
135Autoimmune hemolytic anemia (HP:0001890)1.71455289
136Abnormality of iron homeostasis (HP:0011031)1.69191840
137Easy fatigability (HP:0003388)1.68088464
138Generalized aminoaciduria (HP:0002909)1.67917291
139Papillary thyroid carcinoma (HP:0002895)1.67900938
140Lymphopenia (HP:0001888)1.67747041
141Distal lower limb amyotrophy (HP:0008944)1.66834360
142Increased serum lactate (HP:0002151)1.65360552
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.64838036
144Spontaneous hematomas (HP:0007420)1.63416012
1453-Methylglutaconic aciduria (HP:0003535)1.63335512
146Thrombophlebitis (HP:0004418)1.63324062
147Dysostosis multiplex (HP:0000943)1.62986613
148Abnormal hemoglobin (HP:0011902)1.62953215
149Basal ganglia calcification (HP:0002135)1.62935765
150Aplasia/Hypoplasia of the thymus (HP:0010515)1.62517693
151Pulmonary embolism (HP:0002204)1.61803531
152Meningitis (HP:0001287)1.59870507
153Spontaneous abortion (HP:0005268)1.59093217
154Hypertriglyceridemia (HP:0002155)1.58888860
155Retrobulbar optic neuritis (HP:0100654)1.57597038
156Optic neuritis (HP:0100653)1.57597038
157Recurrent fungal infections (HP:0002841)1.55658919
158Orchitis (HP:0100796)1.55160634
159Vasculitis (HP:0002633)1.54307833
160Cerebral ischemia (HP:0002637)1.50860994
161Eosinophilia (HP:0001880)1.50701512
162Mucosal telangiectasiae (HP:0100579)1.50266988
163Gastrointestinal infarctions (HP:0005244)1.50073298
164Recurrent gram-negative bacterial infections (HP:0005420)1.49201112
165Abnormal ciliary motility (HP:0012262)1.48428691
166Hemorrhage of the eye (HP:0011885)1.46845171
167Muscle fibrillation (HP:0010546)1.44857246
168Increased IgE level (HP:0003212)1.43790898
169Urticaria (HP:0001025)1.43139351
170Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.41007283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.30502728
2BMX3.88098922
3MST43.82042162
4STK163.04156414
5TIE12.92966183
6WEE12.79766602
7MAP4K12.76102365
8TGFBR12.59969176
9NME22.59649718
10GRK62.55322997
11CDK192.54644586
12CDC72.43902361
13PTK2B2.41604129
14KIT2.41350804
15CCNB12.23028779
16ACVR1B2.16629053
17VRK12.15538401
18TEC2.00048303
19MKNK11.98296257
20BTK1.97838007
21MAPKAPK51.96332060
22MAP2K31.93911023
23MUSK1.91187697
24FGR1.90141937
25BRSK21.86721784
26BMPR21.84523112
27PIM21.82992348
28GRK51.78663286
29NEK21.78661610
30HCK1.77358649
31TGFBR21.71926428
32CDK81.66548283
33MATK1.62937578
34DYRK31.61497548
35CAMKK21.61487498
36TXK1.59181653
37PIK3CG1.57910678
38KDR1.50078232
39TSSK61.49619001
40TAOK11.44975278
41EIF2AK11.43194425
42RPS6KB21.41927468
43CSK1.39964668
44JAK31.35164507
45ZAP701.30697117
46TAOK21.26825956
47MAP3K31.24578975
48SIK31.20786713
49PASK1.18517015
50BRSK11.17986360
51NEK11.14893926
52SYK1.14886981
53STK31.13712079
54TBK11.12971582
55STK241.12403720
56ERN11.11409317
57MAP3K61.08628802
58BCKDK1.08537280
59PAK11.08278644
60EEF2K1.06616710
61TYK21.02330081
62FLT31.01683805
63TAOK31.00843957
64CSF1R1.00354133
65LRRK20.99411591
66ATR0.99013445
67ITK0.98997801
68MAP3K120.98968781
69TLK10.98112395
70DAPK30.96258107
71CDK70.96189963
72MARK30.96184334
73DAPK10.96152206
74MAP3K50.93941794
75TNIK0.93282398
76LYN0.92993392
77SCYL20.91352108
78PIM10.89799897
79NEK90.89479404
80RPS6KA40.87133798
81AURKB0.86918290
82TESK20.86799964
83IKBKB0.85943783
84PDK10.85895331
85PKN20.83928904
86IRAK40.83452544
87BLK0.80563590
88EPHB10.79340597
89DAPK20.78965125
90RPS6KA50.78438712
91PDPK10.77710849
92BUB10.77595550
93IRAK10.76735291
94EIF2AK30.74119959
95ADRBK10.73107293
96RET0.69760050
97PAK40.68593367
98MAP2K60.68099445
99SRPK10.67706582
100JAK20.67535332
101EPHA30.67353829
102IKBKE0.64846960
103PIK3CA0.63156705
104STK40.62578048
105PLK20.62085421
106MAPKAPK30.61602396
107TNK20.61476439
108HIPK20.61409300
109PRKG20.60657332
110MAP3K10.59841767
111YES10.58802388
112FYN0.58421637
113PRKD10.58232441
114ERBB20.56532132
115PINK10.55992941
116PLK10.55150604
117PKN10.55077066
118ILK0.53424361
119ADRBK20.53362829
120CAMKK10.53280736
121MAP3K110.53053030
122JAK10.51844049
123LCK0.51133260
124PDGFRB0.51106541
125CLK10.50106449
126LMTK20.50011475
127PLK40.47351284
128CDK60.47145634
129PRKACG0.46812377
130CAMK10.46795420
131MAPK40.46228536
132MAPK110.45502169
133RAF10.44458190
134FES0.44269419
135DYRK1B0.44234032
136MAP3K80.42680702
137MAPK120.42306055
138RPS6KA60.41572075
139MAP2K10.41304937
140ZAK0.40426699
141CDK40.40039441
142MKNK20.39522887
143ARAF0.39050184
144MYLK0.38792949
145EPHB20.37946805
146MAPK150.37771483
147PRKCD0.37338555
148PRKCQ0.35923579
149IRAK20.35808675
150MAPK130.30753032
151FER0.30099910
152PRKG10.27861036
153TRIM280.27764113
154MARK20.24627886
155PRKCB0.22173834
156PNCK0.21524622
157SRC0.21243669
158SGK30.20769915
159PRKD20.20655772
160PRKCA0.20256137
161MINK10.18803060

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.90637107
2Ribosome_Homo sapiens_hsa030105.15613214
3Mismatch repair_Homo sapiens_hsa034304.24564684
4Base excision repair_Homo sapiens_hsa034103.77708094
5Homologous recombination_Homo sapiens_hsa034402.90282197
6Pyrimidine metabolism_Homo sapiens_hsa002402.60549661
7Nucleotide excision repair_Homo sapiens_hsa034202.53547740
8Chemokine signaling pathway_Homo sapiens_hsa040622.13517076
9Spliceosome_Homo sapiens_hsa030402.13512250
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.03650653
11RNA polymerase_Homo sapiens_hsa030201.99610063
12* Platelet activation_Homo sapiens_hsa046111.98324611
13Cell cycle_Homo sapiens_hsa041101.93464365
14Folate biosynthesis_Homo sapiens_hsa007901.90639910
15Protein export_Homo sapiens_hsa030601.86553260
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80830583
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80212096
18* Hematopoietic cell lineage_Homo sapiens_hsa046401.76049023
19Proteasome_Homo sapiens_hsa030501.62929166
20Gap junction_Homo sapiens_hsa045401.56763251
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46936578
22RNA degradation_Homo sapiens_hsa030181.43407623
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.43372647
24Endocytosis_Homo sapiens_hsa041441.41390254
25Fanconi anemia pathway_Homo sapiens_hsa034601.40696188
26T cell receptor signaling pathway_Homo sapiens_hsa046601.37768185
27Staphylococcus aureus infection_Homo sapiens_hsa051501.35493165
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35290102
29Purine metabolism_Homo sapiens_hsa002301.34460159
30* ECM-receptor interaction_Homo sapiens_hsa045121.33568760
31N-Glycan biosynthesis_Homo sapiens_hsa005101.33439932
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.31559401
33Collecting duct acid secretion_Homo sapiens_hsa049661.31150150
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30316897
35Nitrogen metabolism_Homo sapiens_hsa009101.29524088
36Primary immunodeficiency_Homo sapiens_hsa053401.28902572
37Serotonergic synapse_Homo sapiens_hsa047261.25637120
38Herpes simplex infection_Homo sapiens_hsa051681.24554636
39Systemic lupus erythematosus_Homo sapiens_hsa053221.23985413
40Phagosome_Homo sapiens_hsa041451.22261650
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17239293
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16020463
43RNA transport_Homo sapiens_hsa030131.14903734
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.13831191
45Antigen processing and presentation_Homo sapiens_hsa046121.12902638
46B cell receptor signaling pathway_Homo sapiens_hsa046621.12859780
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08470937
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07420347
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07236543
50p53 signaling pathway_Homo sapiens_hsa041151.07173689
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06145631
52One carbon pool by folate_Homo sapiens_hsa006701.05499407
53Other glycan degradation_Homo sapiens_hsa005111.04619373
54Graft-versus-host disease_Homo sapiens_hsa053321.02661847
55Measles_Homo sapiens_hsa051620.99116371
56Pancreatic secretion_Homo sapiens_hsa049720.97904335
57Legionellosis_Homo sapiens_hsa051340.97195258
58Allograft rejection_Homo sapiens_hsa053300.96536873
59Sulfur relay system_Homo sapiens_hsa041220.95388710
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95324051
61Glycerolipid metabolism_Homo sapiens_hsa005610.95020399
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93695974
63Rap1 signaling pathway_Homo sapiens_hsa040150.93215396
64Tuberculosis_Homo sapiens_hsa051520.89348599
65Leishmaniasis_Homo sapiens_hsa051400.89250837
66Autoimmune thyroid disease_Homo sapiens_hsa053200.88144838
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86716231
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85514438
69Basal transcription factors_Homo sapiens_hsa030220.82843370
70Non-homologous end-joining_Homo sapiens_hsa034500.82398171
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81315503
72Long-term depression_Homo sapiens_hsa047300.81123189
73Apoptosis_Homo sapiens_hsa042100.78954095
74Olfactory transduction_Homo sapiens_hsa047400.78915086
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.77090219
76Choline metabolism in cancer_Homo sapiens_hsa052310.76996981
77Acute myeloid leukemia_Homo sapiens_hsa052210.76636887
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76254377
79Asthma_Homo sapiens_hsa053100.73660770
80Focal adhesion_Homo sapiens_hsa045100.73415777
81Shigellosis_Homo sapiens_hsa051310.72887319
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.72826689
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72441416
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72384423
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.72164745
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71241657
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.70866693
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.70492750
89Sulfur metabolism_Homo sapiens_hsa009200.66672960
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66483794
91Morphine addiction_Homo sapiens_hsa050320.65412037
92Epstein-Barr virus infection_Homo sapiens_hsa051690.64123434
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63328027
94Galactose metabolism_Homo sapiens_hsa000520.63269651
95Endometrial cancer_Homo sapiens_hsa052130.61258040
96Amoebiasis_Homo sapiens_hsa051460.61036220
97Ras signaling pathway_Homo sapiens_hsa040140.59875790
98Viral myocarditis_Homo sapiens_hsa054160.59772307
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58821413
100VEGF signaling pathway_Homo sapiens_hsa043700.58374921
101Parkinsons disease_Homo sapiens_hsa050120.58265000
102Circadian entrainment_Homo sapiens_hsa047130.57471836
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57290103
104Rheumatoid arthritis_Homo sapiens_hsa053230.57287217
105Influenza A_Homo sapiens_hsa051640.57193499
106Pentose phosphate pathway_Homo sapiens_hsa000300.57147581
107Linoleic acid metabolism_Homo sapiens_hsa005910.56872981
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.56384316
109Renal cell carcinoma_Homo sapiens_hsa052110.56104573
110Hepatitis B_Homo sapiens_hsa051610.55949972
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55816119
112Alcoholism_Homo sapiens_hsa050340.53795030
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.53577162
114Viral carcinogenesis_Homo sapiens_hsa052030.52958396
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51976697
116Glutathione metabolism_Homo sapiens_hsa004800.51581339
117African trypanosomiasis_Homo sapiens_hsa051430.49577520
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.49321552
119Pertussis_Homo sapiens_hsa051330.48757882
120Notch signaling pathway_Homo sapiens_hsa043300.48110007
121Type I diabetes mellitus_Homo sapiens_hsa049400.48023448
122Chronic myeloid leukemia_Homo sapiens_hsa052200.47086600
123Calcium signaling pathway_Homo sapiens_hsa040200.46851206
124Toxoplasmosis_Homo sapiens_hsa051450.46445036
125Small cell lung cancer_Homo sapiens_hsa052220.44694959
126Malaria_Homo sapiens_hsa051440.44175528
127Osteoclast differentiation_Homo sapiens_hsa043800.43827657
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43762899
129Renin-angiotensin system_Homo sapiens_hsa046140.43494490
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41408900
131HTLV-I infection_Homo sapiens_hsa051660.40785493
132Arachidonic acid metabolism_Homo sapiens_hsa005900.40783490
133TNF signaling pathway_Homo sapiens_hsa046680.40569514
134Gastric acid secretion_Homo sapiens_hsa049710.40540550
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40391901
136Glioma_Homo sapiens_hsa052140.39109507
137Cholinergic synapse_Homo sapiens_hsa047250.38750507
138Regulation of autophagy_Homo sapiens_hsa041400.38510122
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38438414
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38206185
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37888892
142Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37876965
143Selenocompound metabolism_Homo sapiens_hsa004500.37487404
144Thyroid cancer_Homo sapiens_hsa052160.34083179
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33438898
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32662914
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31150405
148mRNA surveillance pathway_Homo sapiens_hsa030150.30033664
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27215244
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26668568
151Huntingtons disease_Homo sapiens_hsa050160.25939187
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25918551
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25758658
154Metabolic pathways_Homo sapiens_hsa011000.25047909
155Pancreatic cancer_Homo sapiens_hsa052120.24227766
156Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23394559
157Fructose and mannose metabolism_Homo sapiens_hsa000510.23102004
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22782067
159Salmonella infection_Homo sapiens_hsa051320.19628034
160ABC transporters_Homo sapiens_hsa020100.19148133
161Non-small cell lung cancer_Homo sapiens_hsa052230.18944918

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